BPIFA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The encoded antimicrobial protein displays antibacterial activity against Gram-negative bacteria. It is thought to be involved in inflammatory responses to irritants in the upper airways and may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)9.72594747
2renal absorption (GO:0070293)9.68104866
3diterpenoid biosynthetic process (GO:0016102)9.09060146
4axoneme assembly (GO:0035082)9.08459906
5left/right pattern formation (GO:0060972)8.33377343
6extracellular regulation of signal transduction (GO:1900115)7.24450064
7extracellular negative regulation of signal transduction (GO:1900116)7.24450064
8negative regulation of complement activation (GO:0045916)6.98846620
9terpenoid biosynthetic process (GO:0016114)6.45959734
10cardiovascular system development (GO:0072358)6.35154395
11regulation of cilium movement (GO:0003352)6.33564422
12sensory perception of smell (GO:0007608)6.32414926
13negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)6.16479056
14left/right axis specification (GO:0070986)6.15090102
15retinoic acid metabolic process (GO:0042573)5.96166625
16negative regulation of protein activation cascade (GO:2000258)5.95739122
17ventricular system development (GO:0021591)5.81088926
18microtubule bundle formation (GO:0001578)5.71232453
19negative regulation of humoral immune response (GO:0002921)5.55492187
20intraciliary transport (GO:0042073)5.49806972
21pyrimidine-containing compound transmembrane transport (GO:0072531)5.48644768
22tolerance induction (GO:0002507)5.39244304
23O-glycan processing (GO:0016266)5.27914638
24lung epithelium development (GO:0060428)5.27155807
25cilium organization (GO:0044782)5.10238740
26cilium assembly (GO:0042384)4.96281266
27sperm capacitation (GO:0048240)4.89418764
28activation of MAPKKK activity (GO:0000185)4.88167198
29positive regulation of tolerance induction (GO:0002645)4.82768822
30retinol metabolic process (GO:0042572)4.76573341
31centriole assembly (GO:0098534)4.75734147
32establishment of apical/basal cell polarity (GO:0035089)4.72622533
33negative regulation of immunoglobulin mediated immune response (GO:0002890)4.71728136
34negative regulation of B cell mediated immunity (GO:0002713)4.71728136
35negative regulation of T cell differentiation in thymus (GO:0033085)4.59926629
36negative regulation of epidermal cell differentiation (GO:0045605)4.59499994
37glomerular epithelial cell development (GO:0072310)4.55732620
38response to xenobiotic stimulus (GO:0009410)4.50479917
39regulation of germinal center formation (GO:0002634)4.43938571
40L-ascorbic acid metabolic process (GO:0019852)4.39896264
41amyloid precursor protein catabolic process (GO:0042987)4.25241014
42regulation of interleukin-5 production (GO:0032674)4.21223324
43sulfur amino acid catabolic process (GO:0000098)4.17553981
44valine metabolic process (GO:0006573)4.16671695
45regulation of toll-like receptor 4 signaling pathway (GO:0034143)4.16187574
46protein localization to cilium (GO:0061512)4.04729038
47establishment of monopolar cell polarity (GO:0061162)4.02757631
48establishment or maintenance of monopolar cell polarity (GO:0061339)4.02757631
49negative regulation of toll-like receptor signaling pathway (GO:0034122)4.01584056
50microtubule-based movement (GO:0007018)3.99645680
51cellular component assembly involved in morphogenesis (GO:0010927)3.94921827
52regulation of interleukin-13 production (GO:0032656)3.84020615
53establishment of planar polarity (GO:0001736)3.79438763
54establishment of tissue polarity (GO:0007164)3.79438763
55primary alcohol metabolic process (GO:0034308)3.75533919
56cytoplasmic microtubule organization (GO:0031122)3.72155533
57regulation of tolerance induction (GO:0002643)3.69632573
58cell projection assembly (GO:0030031)3.69569101
59regulation of microtubule-based movement (GO:0060632)3.66731841
60atrioventricular valve morphogenesis (GO:0003181)3.66633490
61hypotonic response (GO:0006971)3.66542796
62oligosaccharide biosynthetic process (GO:0009312)3.64690051
63progesterone metabolic process (GO:0042448)3.63091942
64endocardial cushion morphogenesis (GO:0003203)3.58956351
65sensory perception of chemical stimulus (GO:0007606)3.54937261
66cilium morphogenesis (GO:0060271)3.51149116
67one-carbon compound transport (GO:0019755)3.50305163
68vitamin transmembrane transport (GO:0035461)3.49393883
69negative regulation of epidermis development (GO:0045683)3.48084275
70nucleoside diphosphate phosphorylation (GO:0006165)3.45859356
71positive regulation of coagulation (GO:0050820)3.43769788
72surfactant homeostasis (GO:0043129)3.41858410
73exogenous drug catabolic process (GO:0042738)3.37783594
74negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.35193151
75regulation of cholesterol biosynthetic process (GO:0045540)3.32658570
76negative regulation of cytosolic calcium ion concentration (GO:0051481)3.32532185
77polyol transport (GO:0015791)3.31860989
78positive regulation of osteoblast proliferation (GO:0033690)3.29338671
79excretion (GO:0007588)3.27855991
80xenobiotic catabolic process (GO:0042178)3.26510401
81positive regulation of wound healing (GO:0090303)3.25833387
82uronic acid metabolic process (GO:0006063)3.23134308
83glucuronate metabolic process (GO:0019585)3.23134308
84positive regulation of steroid biosynthetic process (GO:0010893)3.21989899
85lymphangiogenesis (GO:0001946)3.20386357
86cytokine production involved in immune response (GO:0002367)3.19231458
87hydrogen peroxide biosynthetic process (GO:0050665)3.18389188
88positive regulation of hemostasis (GO:1900048)3.17263099
89positive regulation of blood coagulation (GO:0030194)3.17263099
90toxin metabolic process (GO:0009404)3.13082636
91ovulation cycle (GO:0042698)3.12260030
92glutathione derivative biosynthetic process (GO:1901687)3.12107382
93glutathione derivative metabolic process (GO:1901685)3.12107382
94fatty acid oxidation (GO:0019395)3.11080217
95adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.09253956
96negative regulation of inclusion body assembly (GO:0090084)3.07887274
97iron ion import (GO:0097286)3.06801817
98peptide catabolic process (GO:0043171)3.05939110
99lipid oxidation (GO:0034440)3.04514042
100regulation of keratinocyte proliferation (GO:0010837)3.04418563
101protein O-linked glycosylation (GO:0006493)3.03641258
102apoptotic cell clearance (GO:0043277)3.03049782
103microtubule depolymerization (GO:0007019)3.02121650
104ear development (GO:0043583)3.00779710
105axonemal dynein complex assembly (GO:0070286)20.3474009
106retinal metabolic process (GO:0042574)2.98995624
107regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.97106411
108amyloid precursor protein metabolic process (GO:0042982)2.97005256
109microtubule polymerization or depolymerization (GO:0031109)2.96782735
110phospholipid homeostasis (GO:0055091)2.96527749
111bundle of His cell to Purkinje myocyte communication (GO:0086069)2.95058345
112chemical homeostasis within a tissue (GO:0048875)2.94252525
113aldehyde catabolic process (GO:0046185)2.91024536
114phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.89927061
115antigen processing and presentation via MHC class Ib (GO:0002475)2.88109270
116* multicellular organismal water homeostasis (GO:0050891)2.86678611
117sodium ion homeostasis (GO:0055078)2.85750653
118reactive oxygen species biosynthetic process (GO:1903409)2.84592607
119lateral ventricle development (GO:0021670)2.84170174
120regulation of microtubule depolymerization (GO:0031114)2.83365863
121cellular copper ion homeostasis (GO:0006878)2.82952161
122positive regulation of smoothened signaling pathway (GO:0045880)2.82824454
123acute inflammatory response (GO:0002526)2.81558176
124positive regulation of macrophage activation (GO:0043032)2.81367421
125hydrogen peroxide catabolic process (GO:0042744)2.79778279
126regulation of potassium ion transmembrane transporter activity (GO:1901016)2.77745770
127opioid receptor signaling pathway (GO:0038003)2.76460629
128chemosensory behavior (GO:0007635)2.75702385
129tachykinin receptor signaling pathway (GO:0007217)2.74809675
130regulation of apoptotic cell clearance (GO:2000425)2.72386512
131regulation of keratinocyte differentiation (GO:0045616)2.72194035
132positive regulation of digestive system process (GO:0060456)2.71583397
133alcohol catabolic process (GO:0046164)2.67729787
134mesenchyme morphogenesis (GO:0072132)2.65650550
135hormone catabolic process (GO:0042447)2.65642899
136positive regulation of p38MAPK cascade (GO:1900745)2.64800460
137lateral sprouting from an epithelium (GO:0060601)2.64713334
138drug catabolic process (GO:0042737)2.64136341
139regulation of response to osmotic stress (GO:0047484)2.63911160
140long-chain fatty acid biosynthetic process (GO:0042759)2.63868312
141positive regulation of respiratory burst (GO:0060267)2.62668197
142regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.62067906
143carnitine metabolic process (GO:0009437)2.59470149
144beta-amyloid metabolic process (GO:0050435)2.58995590
145regulation of steroid hormone biosynthetic process (GO:0090030)2.55550302
146gas transport (GO:0015669)2.55344717
147dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.55295252
148hydrogen peroxide metabolic process (GO:0042743)2.55085906
149sperm motility (GO:0030317)2.51131661
150intestinal epithelial cell development (GO:0060576)2.51112202
151regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.50868867
152regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.48101292
153apical protein localization (GO:0045176)2.47892122
154positive regulation of extracellular matrix organization (GO:1903055)2.47491889
155high-density lipoprotein particle remodeling (GO:0034375)2.45880349
156negative regulation of hormone biosynthetic process (GO:0032353)2.45844318
157negative regulation of hormone metabolic process (GO:0032351)2.45844318
158cytoskeletal anchoring at plasma membrane (GO:0007016)2.40378329
159regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.36664892
160regulation of secondary heart field cardioblast proliferation (GO:0003266)2.36394126
161regulation of cardioblast proliferation (GO:0003264)2.36394126
162xenobiotic metabolic process (GO:0006805)2.35816050
163folic acid transport (GO:0015884)2.35605208
164vagina development (GO:0060068)2.35253854
165positive regulation of steroid metabolic process (GO:0045940)2.34962827
166calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.33594250
167sequestering of metal ion (GO:0051238)2.32246651
168protein carboxylation (GO:0018214)2.31626972
169peptidyl-glutamic acid carboxylation (GO:0017187)2.31626972
170heart valve morphogenesis (GO:0003179)2.30178885
171positive regulation of macrophage cytokine production (GO:0060907)2.30102085
172water-soluble vitamin biosynthetic process (GO:0042364)2.29766487
173phenylpropanoid metabolic process (GO:0009698)2.28957234
174regulation of toll-like receptor signaling pathway (GO:0034121)2.28096299
175ethanol oxidation (GO:0006069)19.1575448
176primary alcohol catabolic process (GO:0034310)16.2755428
177cilium or flagellum-dependent cell motility (GO:0001539)15.8200137
178cilium movement (GO:0003341)14.2293109
179ethanol metabolic process (GO:0006067)13.5608128
180motile cilium assembly (GO:0044458)13.2565315
181epithelial cilium movement (GO:0003351)12.4450586
182epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)12.1956884

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.93288636
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.84400865
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.57280588
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.39868804
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.17732395
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.15528373
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.14191253
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.65015978
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.57654980
10FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.56770071
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.54502151
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.53442056
13GATA1_22025678_ChIP-Seq_K562_Human2.36224845
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.33550669
15SOX2_27498859_Chip-Seq_STOMACH_Mouse2.31750172
16DROSHA_22980978_ChIP-Seq_HELA_Human2.13413337
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.07447018
18AHR_22903824_ChIP-Seq_MCF-7_Human2.02039368
19ESR1_20079471_ChIP-ChIP_T-47D_Human2.00938817
20ZNF217_24962896_ChIP-Seq_MCF-7_Human1.98410923
21LXR_22158963_ChIP-Seq_LIVER_Mouse1.95094035
22RXR_22158963_ChIP-Seq_LIVER_Mouse1.94890256
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.93760997
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.88443074
25P63_26484246_Chip-Seq_KERATINOCYTES_Human1.83206062
26CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.79144064
27ZNF263_19887448_ChIP-Seq_K562_Human1.78067653
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.77066911
29NRF2_20460467_ChIP-Seq_MEFs_Mouse1.72199308
30NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.72199308
31RXR_22108803_ChIP-Seq_LS180_Human1.69860937
32ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.68860313
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.54448897
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.54354267
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54276477
36CTNNB1_20460455_ChIP-Seq_HCT116_Human1.53264856
37EP300_21415370_ChIP-Seq_HL-1_Mouse1.51266780
38ARNT_22903824_ChIP-Seq_MCF-7_Human1.50883680
39KLF5_25053715_ChIP-Seq_YYC3_Human1.49759183
40FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.46905914
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.46215359
42SMC4_20622854_ChIP-Seq_HELA_Human1.44717339
43STAT1_20625510_ChIP-Seq_HELA_Human1.41110511
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.39865679
45GATA3_24758297_ChIP-Seq_MCF-7_Human1.39043136
46CLOCK_20551151_ChIP-Seq_293T_Human1.37906406
47SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.37317877
48ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37300236
49GBX2_23144817_ChIP-Seq_PC3_Human1.37226361
50TP53_18474530_ChIP-ChIP_U2OS_Human1.35005283
51PPARA_22158963_ChIP-Seq_LIVER_Mouse1.34245933
52TP63_22573176_ChIP-Seq_HFKS_Human1.34067790
53PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.33425353
54VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.29767538
55SOX2_20726797_ChIP-Seq_SW620_Human1.26819266
56BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26033351
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25549452
58TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24843551
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22817108
60TDRD3_21172665_ChIP-Seq_MCF-7_Human1.21527360
61RAD21_21589869_ChIP-Seq_MESCs_Mouse1.21150516
62ETV1_20927104_ChIP-Seq_GIST48_Human1.20641068
63FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.20508881
64SMAD3_21741376_ChIP-Seq_HESCs_Human1.20036125
65GATA1_19941826_ChIP-Seq_K562_Human1.19079359
66RUNX1_27514584_Chip-Seq_MCF-7_Human1.18484823
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.17736364
68PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.15945425
69RACK7_27058665_Chip-Seq_MCF-7_Human1.15031731
70NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13811464
71SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13326825
72ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.11934178
73RNF2_18974828_ChIP-Seq_MESCs_Mouse1.11120651
74EZH2_18974828_ChIP-Seq_MESCs_Mouse1.11120651
75FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.10995880
76AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.10718583
77CDX2_20551321_ChIP-Seq_CACO-2_Human1.09564813
78JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09125877
79EZH2_27294783_Chip-Seq_ESCs_Mouse1.08731734
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.08704083
81ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08366412
82FOXA1_25552417_ChIP-Seq_VCAP_Human1.06298619
83GATA1_26923725_Chip-Seq_HPCs_Mouse1.06162579
84SMRT_27268052_Chip-Seq_Bcells_Human1.06012578
85MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05285212
86WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04231338
87SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02246542
88SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.02127843
89EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01597118
90ELF1_20517297_ChIP-Seq_JURKAT_Human1.00872480
91PHF8_20622853_ChIP-Seq_HELA_Human1.00733398
92TCF4_18268006_ChIP-ChIP_LS174T_Human0.99975648
93HNFA_21074721_ChIP-Seq_CACO-2_Human0.99849284
94CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.99265216
95TBX20_22328084_ChIP-Seq_HEART_Mouse0.99078640
96TBX20_22080862_ChIP-Seq_HEART_Mouse0.99078640
97SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98930803
98SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98600255
99SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98600255
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96880792
101VDR_22108803_ChIP-Seq_LS180_Human0.96292503
102CBX2_22325352_ChIP-Seq_293T-Rex_Human0.96045786
103SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95714178
104RBPJ_21746931_ChIP-Seq_IB4_Human0.95330163
105SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95321062
106CTCF_27219007_Chip-Seq_Bcells_Human0.95317915
107RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95014956
108CREB1_26743006_Chip-Seq_LNCaP_Human0.94746928
109NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94712727
110FOXO3_23340844_ChIP-Seq_DLD1_Human0.93787472
111AR_21572438_ChIP-Seq_LNCaP_Human0.93237382
112GATA4_25053715_ChIP-Seq_YYC3_Human0.92909606
113CEBPB_22108803_ChIP-Seq_LS180_Human0.92812179
114STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92041078
115Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91892101
116RUNX_20019798_ChIP-Seq_JUKART_Human0.91655463
117TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91640128
118CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90447104
119SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.90372822
120GATA2_19941826_ChIP-Seq_K562_Human0.88738838
121CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88378315
122SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88252591
123KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87393754
124TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86956666
125CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85344564
126SUZ12_27294783_Chip-Seq_ESCs_Mouse0.85209068
127GATA6_21074721_ChIP-Seq_CACO-2_Human0.84969772
128MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84508744
129CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84052730
130PPAR_26484153_Chip-Seq_NCI-H1993_Human0.83461711
131GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.82977152
132FOXM1_26456572_ChIP-Seq_MCF-7_Human0.82890968
133CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82256433
134TP63_23658742_ChIP-Seq_EP156T_Human0.82148314
135KLF4_19829295_ChIP-Seq_ESCs_Human0.81848177
136IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.81674152
137IKZF1_21737484_ChIP-ChIP_HCT116_Human0.81398415
138TAF15_26573619_Chip-Seq_HEK293_Human0.81374353
139FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.80492623
140BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80463229
141RNF2_27304074_Chip-Seq_ESCs_Mouse0.79343981
142TP53_16413492_ChIP-PET_HCT116_Human0.78204986
143NR3C1_21868756_ChIP-Seq_MCF10A_Human0.77466066
144FOXA2_19822575_ChIP-Seq_HepG2_Human0.77299205
145TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77291262
146MYC_27129775_Chip-Seq_CORNEA_Mouse0.77172845
147ISL1_27105846_Chip-Seq_CPCs_Mouse0.76476896
148GATA6_25053715_ChIP-Seq_YYC3_Human0.76166590
149FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.76087922
150NFYA_21822215_ChIP-Seq_K562_Human0.75768746
151OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.75590908
152P300_27268052_Chip-Seq_Bcells_Human0.73040770

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok8.85314347
2MP0004043_abnormal_pH_regulation5.94757921
3MP0004019_abnormal_vitamin_homeostasis4.41135920
4MP0001984_abnormal_olfaction4.25315664
5MP0010368_abnormal_lymphatic_system3.92458359
6MP0000566_synostosis3.07573913
7MP0002132_abnormal_respiratory_system2.97065136
8MP0008789_abnormal_olfactory_epithelium2.94219937
9MP0003183_abnormal_peptide_metabolism2.88817831
10MP0004264_abnormal_extraembryonic_tissu2.86236159
11MP0010030_abnormal_orbit_morphology2.67552611
12MP0006054_spinal_hemorrhage2.66110942
13MP0010234_abnormal_vibrissa_follicle2.64041261
14MP0004133_heterotaxia2.55326480
15MP0005623_abnormal_meninges_morphology2.54861267
16MP0003828_pulmonary_edema2.49766594
17MP0005409_darkened_coat_color2.49191887
18MP0001346_abnormal_lacrimal_gland2.44580610
19MP0010678_abnormal_skin_adnexa2.41872485
20MP0005499_abnormal_olfactory_system2.35775504
21MP0005394_taste/olfaction_phenotype2.35775504
22MP0000383_abnormal_hair_follicle2.26809425
23MP0003656_abnormal_erythrocyte_physiolo2.18001892
24MP0002168_other_aberrant_phenotype2.09144621
25MP0003186_abnormal_redox_activity2.07964059
26MP0003329_amyloid_beta_deposits2.05791756
27MP0010155_abnormal_intestine_physiology1.86904953
28MP0009379_abnormal_foot_pigmentation1.65478912
29MP0001188_hyperpigmentation1.60454281
30MP0002282_abnormal_trachea_morphology1.60053617
31MP0003172_abnormal_lysosome_physiology1.59458263
32MP0003303_peritoneal_inflammation1.51002194
33MP0005365_abnormal_bile_salt1.50691842
34MP0005408_hypopigmentation1.50671768
35MP0002277_abnormal_respiratory_mucosa1.48561579
36MP0003724_increased_susceptibility_to1.44505406
37MP0005377_hearing/vestibular/ear_phenot1.44400537
38MP0003878_abnormal_ear_physiology1.44400537
39MP0003453_abnormal_keratinocyte_physiol1.43358980
40MP0001879_abnormal_lymphatic_vessel1.39126616
41MP0002909_abnormal_adrenal_gland1.38509153
42MP0005310_abnormal_salivary_gland1.38170239
43MP0002160_abnormal_reproductive_system1.36552139
44MP0004782_abnormal_surfactant_physiolog1.31206765
45MP0003941_abnormal_skin_development1.31119410
46MP0002295_abnormal_pulmonary_circulatio1.29118918
47MP0005395_other_phenotype1.26118715
48MP0000371_diluted_coat_color1.25434520
49MP0001915_intracranial_hemorrhage1.25004598
50MP0000858_altered_metastatic_potential1.24652476
51MP0005388_respiratory_system_phenotype1.23991797
52MP0002133_abnormal_respiratory_system1.23991797
53MP0001756_abnormal_urination1.23727679
54MP0009780_abnormal_chondrocyte_physiolo1.21798164
55MP0010329_abnormal_lipoprotein_level1.20044303
56MP0010352_gastrointestinal_tract_polyps1.19384918
57MP0005165_increased_susceptibility_to1.17852056
58MP0002653_abnormal_ependyma_morphology1.17367109
59MP0004858_abnormal_nervous_system1.17045848
60MP0009764_decreased_sensitivity_to1.15240236
61MP0001849_ear_inflammation1.12780841
62MP0001958_emphysema1.12105124
63MP0009643_abnormal_urine_homeostasis1.11484772
64MP0000604_amyloidosis1.11183933
65MP0003075_altered_response_to1.10979378
66MP0002254_reproductive_system_inflammat1.10915071
67MP0005646_abnormal_pituitary_gland1.10658469
68MP0003279_aneurysm1.09347394
69MP0003633_abnormal_nervous_system1.09083799
70MP0004883_abnormal_blood_vessel1.09037888
71MP0009278_abnormal_bone_marrow1.08543940
72MP0003566_abnormal_cell_adhesion1.07848915
73MP0005167_abnormal_blood-brain_barrier1.06722364
74MP0000681_abnormal_thyroid_gland1.05250876
75MP0002249_abnormal_larynx_morphology1.04989012
76MP0005058_abnormal_lysosome_morphology1.04881627
77MP0000465_gastrointestinal_hemorrhage1.02347741
78MP0005085_abnormal_gallbladder_physiolo0.99329441
79MP0005503_abnormal_tendon_morphology0.97997395
80MP0008004_abnormal_stomach_pH0.96819246
81MP0002139_abnormal_hepatobiliary_system0.96505423
82MP0000613_abnormal_salivary_gland0.96216377
83MP0005164_abnormal_response_to0.92190396
84MP0008961_abnormal_basal_metabolism0.90069316
85MP0002877_abnormal_melanocyte_morpholog0.89743623
86MP0003866_abnormal_defecation0.86739167
87MP0002735_abnormal_chemical_nociception0.85710647
88MP0005166_decreased_susceptibility_to0.85240754
89MP0000249_abnormal_blood_vessel0.83688528
90MP0003690_abnormal_glial_cell0.83300225
91MP0009765_abnormal_xenobiotic_induced0.81339007
92MP0001177_atelectasis0.80013891
93MP0001270_distended_abdomen0.77177689
94MP0009763_increased_sensitivity_to0.75673324
95MP0005387_immune_system_phenotype0.75221581
96MP0001790_abnormal_immune_system0.75221581
97MP0002896_abnormal_bone_mineralization0.74530289
98MP0005636_abnormal_mineral_homeostasis0.72576922
99MP0001542_abnormal_bone_strength0.72284055
100MP0003631_nervous_system_phenotype0.71369048
101MP0002098_abnormal_vibrissa_morphology0.68205025
102MP0002734_abnormal_mechanical_nocicepti0.68019079
103MP0002136_abnormal_kidney_physiology0.67778163
104MP0001186_pigmentation_phenotype0.67690810
105MP0005248_abnormal_Harderian_gland0.67078857
106MP0001765_abnormal_ion_homeostasis0.66370315
107MP0003632_abnormal_nervous_system0.65842489
108MP0001666_abnormal_nutrient_absorption0.65469704
109MP0002876_abnormal_thyroid_physiology0.65127172
110MP0001485_abnormal_pinna_reflex0.64923344
111MP0000467_abnormal_esophagus_morphology0.64454366
112MP0002638_abnormal_pupillary_reflex0.63166336
113MP0001545_abnormal_hematopoietic_system0.62986995
114MP0005397_hematopoietic_system_phenotyp0.62986995
115MP0001502_abnormal_circadian_rhythm0.62721087
116MP0005220_abnormal_exocrine_pancreas0.62527295
117MP0003950_abnormal_plasma_membrane0.61931217
118MP0003890_abnormal_embryonic-extraembry0.60854933
119MP0002075_abnormal_coat/hair_pigmentati0.60447080
120MP0003191_abnormal_cellular_cholesterol0.59771933
121MP0002233_abnormal_nose_morphology0.59291314
122MP0005083_abnormal_biliary_tract0.59200280
123MP0001664_abnormal_digestion0.58838627
124MP0002118_abnormal_lipid_homeostasis0.58423830
125MP0001299_abnormal_eye_distance/0.58073723
126MP0002128_abnormal_blood_circulation0.56061173
127MP0005595_abnormal_vascular_smooth0.56059003
128MP0002796_impaired_skin_barrier0.54627710
129MP0001968_abnormal_touch/_nociception0.54139672
130MP0005389_reproductive_system_phenotype0.54115163
131MP0008995_early_reproductive_senescence0.53590374
132MP0005376_homeostasis/metabolism_phenot0.52978236
133MP0001216_abnormal_epidermal_layer0.52807027
134MP0000762_abnormal_tongue_morphology0.52760364
135MP0002405_respiratory_system_inflammati0.52710897
136MP0010630_abnormal_cardiac_muscle0.52689664
137MP0000579_abnormal_nail_morphology0.51576915
138MP0009053_abnormal_anal_canal0.49948844
139MP0002060_abnormal_skin_morphology0.48922906
140MP0004272_abnormal_basement_membrane0.48098607
141MP0002089_abnormal_postnatal_growth/wei0.48070341
142MP0005025_abnormal_response_to0.47223360
143MP0003045_fibrosis0.46995870
144MP0001663_abnormal_digestive_system0.46568225
145MP0003300_gastrointestinal_ulcer0.46126894
146MP0000678_abnormal_parathyroid_gland0.44834054
147MP0005023_abnormal_wound_healing0.44172841
148MP0000343_altered_response_to0.43370295
149MP0006082_CNS_inflammation0.43368671

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)8.51380617
2Hypokalemic alkalosis (HP:0001949)7.64668460
3Bronchiectasis (HP:0002110)7.56965973
4Large eyes (HP:0001090)7.16691468
5Hyperaldosteronism (HP:0000859)7.16286036
6Nasal polyposis (HP:0100582)6.79815750
7Metabolic alkalosis (HP:0200114)6.78585719
8Tetany (HP:0001281)6.35063228
9Abnormality of renin-angiotensin system (HP:0000847)6.22183560
10Renal salt wasting (HP:0000127)6.16788696
11Polydipsia (HP:0001959)6.15231350
12Abnormal drinking behavior (HP:0030082)6.15231350
13Abnormality of chloride homeostasis (HP:0011422)6.01593763
14Abnormality of the nasal mucosa (HP:0000433)5.64715133
15Hypomagnesemia (HP:0002917)5.56425489
16Abnormality of magnesium homeostasis (HP:0004921)5.11826141
17Impaired platelet aggregation (HP:0003540)5.11700120
18Abnormal platelet function (HP:0011869)5.11700120
19Abnormality of fatty-acid metabolism (HP:0004359)4.64418376
20Bronchitis (HP:0012387)4.55578015
21Recurrent sinusitis (HP:0011108)4.32503205
22Hypercalciuria (HP:0002150)4.29826331
23Chronic sinusitis (HP:0011109)4.21292832
24Infertility (HP:0000789)4.19015116
25Hypokalemia (HP:0002900)4.15709174
26Decreased circulating renin level (HP:0003351)4.04024855
27Scanning speech (HP:0002168)4.03674872
28Male infertility (HP:0003251)4.01449950
29Alkalosis (HP:0001948)3.97573520
30Recurrent otitis media (HP:0000403)3.91146421
31Chondrocalcinosis (HP:0000934)3.87887154
32Polyuria (HP:0000103)3.86839237
33Distal lower limb muscle weakness (HP:0009053)3.81948914
34Abnormal urine output (HP:0012590)3.69718952
35Abnormality of Sharpey fibers (HP:0100685)3.64410360
36Increased neuronal autofluorescent lipopigment (HP:0002074)3.54443235
37Abnormality of renal excretion (HP:0011036)3.49991723
38Adrenal overactivity (HP:0002717)3.46854778
39Increased cerebral lipofuscin (HP:0011813)3.31687338
40Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.30309705
41Chronic otitis media (HP:0000389)3.23348130
42Hypotension (HP:0002615)3.22962831
43Occipital encephalocele (HP:0002085)3.19530947
44Abnormality of potassium homeostasis (HP:0011042)3.14158854
45Atelectasis (HP:0100750)3.02008827
46Syncope (HP:0001279)2.92662703
47Pancreatic fibrosis (HP:0100732)2.89209792
48True hermaphroditism (HP:0010459)2.86095358
49Right ventricular cardiomyopathy (HP:0011663)2.78109470
50Esophageal atresia (HP:0002032)2.70134374
51Upper motor neuron abnormality (HP:0002127)2.42318827
52Cystic liver disease (HP:0006706)2.37236322
53Neurofibrillary tangles (HP:0002185)2.29575286
54Pancreatic cysts (HP:0001737)2.25526854
55Esophageal varix (HP:0002040)2.22127383
56Abnormality of midbrain morphology (HP:0002418)2.21396757
57Molar tooth sign on MRI (HP:0002419)2.21396757
58Nephronophthisis (HP:0000090)2.18018954
59Nephrocalcinosis (HP:0000121)2.14166489
60Absent frontal sinuses (HP:0002688)2.13502793
61Tubulointerstitial nephritis (HP:0001970)2.13318339
62Postaxial foot polydactyly (HP:0001830)2.05912018
63Bell-shaped thorax (HP:0001591)2.04079477
64Chronic hepatic failure (HP:0100626)2.03362741
65Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.6020050
66Hyperactive renin-angiotensin system (HP:0000841)11.0632761
67Abnormal respiratory motile cilium morphology (HP:0005938)11.0496282
68Abnormal respiratory epithelium morphology (HP:0012253)11.0496282
69Abnormal respiratory motile cilium physiology (HP:0012261)10.9983639
70Abnormal ciliary motility (HP:0012262)10.5625346
71Rhinitis (HP:0012384)10.4029022
72Dynein arm defect of respiratory motile cilia (HP:0012255)10.3553902
73Absent/shortened dynein arms (HP:0200106)10.3553902
74Progressive visual loss (HP:0000529)1.99777286
75Atrioventricular block (HP:0001678)1.99395675
76Chronic bronchitis (HP:0004469)1.97156914
77Palpitations (HP:0001962)1.96770046
78Prolonged QT interval (HP:0001657)1.96361410
79Polycythemia (HP:0001901)1.92808459
80Stridor (HP:0010307)1.91082971
81Bilateral sensorineural hearing impairment (HP:0008619)1.90473761
82Degeneration of the lateral corticospinal tracts (HP:0002314)1.89854159
83Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.89854159
84Abnormal hemoglobin (HP:0011902)1.89402845
85Osteomalacia (HP:0002749)1.88473928
86Cerebral inclusion bodies (HP:0100314)1.87671102
87Generalized muscle weakness (HP:0003324)1.87460097
88Clumsiness (HP:0002312)1.86528326
89Decreased subcutaneous fat (HP:0001002)1.84797820
90Ulnar bowing (HP:0003031)1.84592213
91Dehydration (HP:0001944)1.84495171
92Popliteal pterygium (HP:0009756)1.83393903
93Abnormality of binocular vision (HP:0011514)1.80041352
94Diplopia (HP:0000651)1.80041352
95Abnormality of the renal medulla (HP:0100957)1.77859672
96Abnormality of the distal phalanges of the toes (HP:0010182)1.77653818
97Recurrent bronchitis (HP:0002837)1.77529459
98Onycholysis (HP:0001806)1.76876844
99Lip pit (HP:0100267)1.76070023
100Paresthesia (HP:0003401)1.73165867
101Congenital hepatic fibrosis (HP:0002612)1.72414118
102Aplasia/Hypoplasia of the spleen (HP:0010451)1.72048513
103Male pseudohermaphroditism (HP:0000037)1.71123372
104Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.71121539
105Orchitis (HP:0100796)1.67393951
106Asplenia (HP:0001746)1.66801797
107Dysphonia (HP:0001618)1.66091772
108Anencephaly (HP:0002323)1.64500164
109Gastrointestinal atresia (HP:0002589)1.63742404
110Hyperkalemia (HP:0002153)1.63032558
111Aplasia/Hypoplasia of the tongue (HP:0010295)1.62892872
112Abnormal atrioventricular conduction (HP:0005150)1.62062707
113Renal cortical cysts (HP:0000803)1.58905215
114Nephropathy (HP:0000112)1.58070640
115Heart block (HP:0012722)1.55291649
116Renal tubular acidosis (HP:0001947)1.53669671
117Long foot (HP:0001833)1.52639605
118Hyponatremia (HP:0002902)1.51480278
119Abnormality of the corticospinal tract (HP:0002492)1.51471677
120Furrowed tongue (HP:0000221)1.50519245
121Medial flaring of the eyebrow (HP:0010747)1.49223076
122Intention tremor (HP:0002080)1.47215606
123Spastic tetraparesis (HP:0001285)1.46458860
124Abnormal EKG (HP:0003115)1.46386699
125Personality changes (HP:0000751)1.45242784
126Tubular atrophy (HP:0000092)1.43823693
127Annular pancreas (HP:0001734)1.42450874
128Postural tremor (HP:0002174)1.42029149
129Diaphragmatic weakness (HP:0009113)1.41047511
130Congenital primary aphakia (HP:0007707)1.39787707
131Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.39404596
132Median cleft lip (HP:0000161)1.39403551
133Tachypnea (HP:0002789)1.39290292
134Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.38943198
135Oculomotor apraxia (HP:0000657)1.38730160
136Dysostosis multiplex (HP:0000943)1.37710899
137Abnormality of the motor neurons (HP:0002450)1.37209033
138Abnormal neuron morphology (HP:0012757)1.37209033
139Hand muscle atrophy (HP:0009130)1.35298763
140Gait imbalance (HP:0002141)1.34867881
141Abnormality of the frontal sinuses (HP:0002687)1.34402533
142Osteopenia (HP:0000938)1.33446992
143Flat acetabular roof (HP:0003180)1.33378334
144Fragile skin (HP:0001030)1.31132722
145Abnormality of permanent molar morphology (HP:0011071)1.30261150
146Abnormality of the dental root (HP:0006486)1.30261150
147Taurodontia (HP:0000679)1.30261150
148Prominent forehead (HP:0011220)1.29521560
149Abnormality of monocarboxylic acid metabolism (HP:0010996)1.29284823
150Bowing of the arm (HP:0006488)1.29117600
151Bowed forearm bones (HP:0003956)1.29117600
152Bronchomalacia (HP:0002780)1.28843225
153Axonal loss (HP:0003447)1.28132036
154Supernumerary nipples (HP:0002558)1.27804028
155Postaxial hand polydactyly (HP:0001162)1.27594831
156Short hallux (HP:0010109)1.26669054
157Cone-rod dystrophy (HP:0000548)1.26551041
158Segmental peripheral demyelination/remyelination (HP:0003481)1.26037254
159Supraventricular tachycardia (HP:0004755)1.25927055
160Lower limb hyperreflexia (HP:0002395)1.25541919
161Ventricular arrhythmia (HP:0004308)1.25357388
162Amyloidosis (HP:0011034)1.25027365
163Sclerocornea (HP:0000647)1.25012071
164Bifid scrotum (HP:0000048)1.24566242
165Small for gestational age (HP:0001518)1.24010981
166Short thorax (HP:0010306)1.22296569
167Glucose intolerance (HP:0000833)1.22053981
168Short nail (HP:0001799)1.21595334
169Abnormality of molar (HP:0011077)1.20075466
170Abnormality of molar morphology (HP:0011070)1.20075466
171Nephrogenic diabetes insipidus (HP:0009806)1.18822662
172Abnormality of sodium homeostasis (HP:0010931)1.18629230
173Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.18432442
174Fetal akinesia sequence (HP:0001989)1.17998920
175Abnormality of the dental pulp (HP:0006479)1.16282129
176Spinal muscular atrophy (HP:0007269)1.13070731
177Spinal cord compression (HP:0002176)1.12666824
178Carpal bone hypoplasia (HP:0001498)1.11484409
179Hypoplastic labia majora (HP:0000059)1.11289595
180Tubulointerstitial abnormality (HP:0001969)1.09771930
181Aplasia of the musculature (HP:0100854)1.07063068
182Decreased central vision (HP:0007663)1.05656545
183Muscle fiber splitting (HP:0003555)1.03920847
184Short femoral neck (HP:0100864)1.03666406
185Facial cleft (HP:0002006)1.03657490
186Obstructive sleep apnea (HP:0002870)1.03438188
187Abnormality of the labia majora (HP:0012881)0.99845389
188Preaxial hand polydactyly (HP:0001177)0.99455202
189Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)0.99093114

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK36.85394681
2SIK15.21994721
3MST45.05040269
4SIK24.89298382
5EPHA24.46221378
6SGK33.73477983
7SGK23.44612021
8TYRO33.30993394
9SGK4942.96582603
10SGK2232.96582603
11ADRBK22.68867187
12PRKD32.39259890
13SMG12.34906801
14STK242.27303294
15MARK32.06660177
16MAPKAPK32.00619609
17ERN11.91650442
18MST1R1.88371576
19PDK21.68150248
20STK101.64983701
21TAOK11.61857573
22MAP3K121.44501824
23ERBB31.41917473
24INSRR1.40182873
25MAPK151.37821078
26LRRK21.32794128
27DAPK21.32164827
28TTK1.25837461
29RPS6KB21.24991508
30EEF2K1.21374977
31EPHB21.15165541
32PAK31.14046759
33NEK61.13069805
34HIPK21.08593181
35BCR1.04187831
36EPHB11.02143497
37PTK2B0.99456435
38MARK20.95190295
39STK38L0.94592325
40RIPK10.93485256
41CDK60.93331099
42MAP3K70.90289706
43TBK10.88890987
44STK390.88257908
45PBK0.87268656
46MAP2K20.83110369
47ADRBK10.82393877
48LATS10.81647278
49MAP2K30.80389772
50PDK30.77221948
51PDK40.77221948
52PINK10.73262841
53EPHA30.72516326
54FGFR30.72460443
55ICK0.72058610
56PRKG20.67693530
57MET0.66667791
58GRK60.66135419
59ERBB20.66014362
60KSR20.64021494
61RIPK40.63164571
62SGK10.62681796
63TGFBR20.59398955
64MAP3K30.59265656
65CAMKK10.57823255
66TLK10.57292495
67TYK20.54479805
68WNK40.54007041
69TRPM70.52900695
70PNCK0.52895913
71BRSK20.51745736
72DYRK1B0.50964869
73NTRK30.50352315
74MAP2K10.49290658
75FER0.49262688
76TIE10.49253158
77NLK0.47526175
78BMPR20.47486708
79STK380.47180557
80NME10.46773050
81ROCK20.45712083
82NEK90.43220774
83PRKCH0.42997470
84PRKAA20.42996405
85ZAP700.42861248
86PRKCE0.42390384
87PRKD20.41397052
88PRKD10.40479774
89MAP3K20.39972180
90STK160.38871989
91PRKCI0.38675188
92LATS20.38365143
93CAMK2D0.38134245
94OXSR10.34748348
95TTN0.34639264
96BCKDK0.34566648
97PRKCD0.34255877
98PAK40.34058566
99MYLK0.33634021
100TESK10.33374224
101KSR10.32545380
102FYN0.31600011
103CAMK2B0.31196673
104MINK10.31100073
105DMPK0.31097763
106CSK0.30111420
107WNK10.29834121
108ABL10.28295811
109PAK60.27668871
110TRIB30.26031019
111PIM20.25970916
112EGFR0.25890435
113JAK10.25832892
114MAP3K40.25501276
115CDC42BPA0.24557421
116IRAK10.24483205
117PRKCG0.23146113
118MAPK130.22401359
119MATK0.22308389
120MELK0.22205236
121SRC0.21856262
122SCYL20.21635217
123CDK80.21480446
124IKBKE0.21382924
125AURKA0.20047824
126ALK0.19901726
127PRKCQ0.19847493
128TAOK20.19558641
129MAPKAPK50.19294666
130PRKCA0.18595818
131DYRK1A0.18579134
132LMTK20.18449647
133CAMK2A0.17682543
134AKT20.17511305
135CAMK10.17322662
136CAMKK20.16931097
137IGF1R0.16835843
138CAMK2G0.16744811
139PTK60.16425877
140CDK90.16108370
141YES10.15846985
142FGFR40.15705281
143CSNK1G20.15087571
144PDGFRB0.14244880
145MAP2K60.14004334
146PHKG10.13892924
147PHKG20.13892924
148TEC0.13407298
149PRKACA0.13061472
150GRK10.12939370
151PTK20.12867250
152INSR0.12253248
153PDPK10.11800280
154TNIK0.11564972
155MAP3K60.11075592

Predicted pathways (KEGG)

RankGene SetZ-score
1Drug metabolism - cytochrome P450_Homo sapiens_hsa009825.91229684
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.16448683
3Tyrosine metabolism_Homo sapiens_hsa003504.47535054
4Chemical carcinogenesis_Homo sapiens_hsa052044.47382586
5Sulfur metabolism_Homo sapiens_hsa009203.82998782
6Fatty acid degradation_Homo sapiens_hsa000713.48044980
7Retinol metabolism_Homo sapiens_hsa008303.16248936
8Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.90315681
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.74300822
10Histidine metabolism_Homo sapiens_hsa003402.63969141
11Phenylalanine metabolism_Homo sapiens_hsa003602.53752518
12Sulfur relay system_Homo sapiens_hsa041222.38696764
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.21712687
14beta-Alanine metabolism_Homo sapiens_hsa004102.16198555
15Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.09824222
16Huntingtons disease_Homo sapiens_hsa050161.85810776
17Olfactory transduction_Homo sapiens_hsa047401.83569614
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.80708189
19Gastric acid secretion_Homo sapiens_hsa049711.80121055
20Sphingolipid metabolism_Homo sapiens_hsa006001.69505335
21Glutathione metabolism_Homo sapiens_hsa004801.51048305
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37934998
23Linoleic acid metabolism_Homo sapiens_hsa005911.34091897
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25411581
25Selenocompound metabolism_Homo sapiens_hsa004501.21655953
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.17430902
27Circadian rhythm_Homo sapiens_hsa047101.15300627
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14924839
29Steroid hormone biosynthesis_Homo sapiens_hsa001400.94753750
30Hepatitis C_Homo sapiens_hsa051600.86770423
31Complement and coagulation cascades_Homo sapiens_hsa046100.84906150
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84521524
33Other glycan degradation_Homo sapiens_hsa005110.81466789
34Caffeine metabolism_Homo sapiens_hsa002320.77447951
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77107654
36Protein export_Homo sapiens_hsa030600.73229673
37Propanoate metabolism_Homo sapiens_hsa006400.71190748
38Vibrio cholerae infection_Homo sapiens_hsa051100.70924985
39Thyroid hormone synthesis_Homo sapiens_hsa049180.66057922
40Arachidonic acid metabolism_Homo sapiens_hsa005900.63242148
41Glycerolipid metabolism_Homo sapiens_hsa005610.61707537
42Fatty acid elongation_Homo sapiens_hsa000620.61503552
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.60963522
44Salivary secretion_Homo sapiens_hsa049700.59704447
45Leishmaniasis_Homo sapiens_hsa051400.59592176
46Fatty acid metabolism_Homo sapiens_hsa012120.58537542
47Notch signaling pathway_Homo sapiens_hsa043300.57427626
48Choline metabolism in cancer_Homo sapiens_hsa052310.57138991
49Collecting duct acid secretion_Homo sapiens_hsa049660.56501987
50Morphine addiction_Homo sapiens_hsa050320.56065121
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53880905
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52590831
53Staphylococcus aureus infection_Homo sapiens_hsa051500.51018958
54Hematopoietic cell lineage_Homo sapiens_hsa046400.48640753
55Butanoate metabolism_Homo sapiens_hsa006500.47666294
56Lysosome_Homo sapiens_hsa041420.47361054
57Adherens junction_Homo sapiens_hsa045200.46917131
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45853110
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43894077
60Bile secretion_Homo sapiens_hsa049760.43560308
61Allograft rejection_Homo sapiens_hsa053300.42992181
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.42745443
63Tryptophan metabolism_Homo sapiens_hsa003800.42569184
64Type I diabetes mellitus_Homo sapiens_hsa049400.42404549
65Arginine biosynthesis_Homo sapiens_hsa002200.42043048
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40954755
67Autoimmune thyroid disease_Homo sapiens_hsa053200.40689183
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40630812
69Pyruvate metabolism_Homo sapiens_hsa006200.40519504
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39643598
71Steroid biosynthesis_Homo sapiens_hsa001000.39371357
72Graft-versus-host disease_Homo sapiens_hsa053320.39341509
73Circadian entrainment_Homo sapiens_hsa047130.39141595
74Synaptic vesicle cycle_Homo sapiens_hsa047210.38903658
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38184127
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.37278149
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36264326
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35787514
79Peroxisome_Homo sapiens_hsa041460.32965139
80Asthma_Homo sapiens_hsa053100.32799227
81Arginine and proline metabolism_Homo sapiens_hsa003300.32747315
82Starch and sucrose metabolism_Homo sapiens_hsa005000.31787155
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.31329612
84Tight junction_Homo sapiens_hsa045300.31290505
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30527065
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.29513981
87Estrogen signaling pathway_Homo sapiens_hsa049150.28290814
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.26724057
89Insulin secretion_Homo sapiens_hsa049110.26677580
90Ovarian steroidogenesis_Homo sapiens_hsa049130.26603552
91Pancreatic cancer_Homo sapiens_hsa052120.26177082
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.25802586
93Viral myocarditis_Homo sapiens_hsa054160.25447840
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24866388
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.23711828
96Prostate cancer_Homo sapiens_hsa052150.23373524
97Taste transduction_Homo sapiens_hsa047420.22971872
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.22937255
99Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.21110657
100Hedgehog signaling pathway_Homo sapiens_hsa043400.20819052
101Antigen processing and presentation_Homo sapiens_hsa046120.20709157
102Metabolic pathways_Homo sapiens_hsa011000.19801308
103Phagosome_Homo sapiens_hsa041450.19082708
104Mineral absorption_Homo sapiens_hsa049780.18808261
105Insulin resistance_Homo sapiens_hsa049310.18640801
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.18352484
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.18144399
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.17771727
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.17527165
110Influenza A_Homo sapiens_hsa051640.17105832
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.16649325
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.16602577
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.15737255
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.14293622
115TNF signaling pathway_Homo sapiens_hsa046680.14143203
116ABC transporters_Homo sapiens_hsa020100.13787494
117GABAergic synapse_Homo sapiens_hsa047270.13555142
118Nitrogen metabolism_Homo sapiens_hsa009100.13455573
119Pancreatic secretion_Homo sapiens_hsa049720.13234641
120N-Glycan biosynthesis_Homo sapiens_hsa005100.13155144
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.13122736
122Endocytosis_Homo sapiens_hsa041440.12852836
123Rheumatoid arthritis_Homo sapiens_hsa053230.12222056
124Salmonella infection_Homo sapiens_hsa051320.12195198
125Glycosaminoglycan degradation_Homo sapiens_hsa005310.12191919
126Apoptosis_Homo sapiens_hsa042100.12115080
127PPAR signaling pathway_Homo sapiens_hsa033200.11532007
128Toxoplasmosis_Homo sapiens_hsa051450.11306770
129Hippo signaling pathway_Homo sapiens_hsa043900.10930948
130Rap1 signaling pathway_Homo sapiens_hsa040150.10744969
131Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.10345905
132Amoebiasis_Homo sapiens_hsa051460.09834854
133Carbon metabolism_Homo sapiens_hsa012000.09745230
134Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.09594173
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.09255406
136Tuberculosis_Homo sapiens_hsa051520.08206799
137Amphetamine addiction_Homo sapiens_hsa050310.07378763
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.07284939
139Axon guidance_Homo sapiens_hsa043600.06976599
140Calcium signaling pathway_Homo sapiens_hsa040200.06705661
141Toll-like receptor signaling pathway_Homo sapiens_hsa046200.06177215
142Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.06073150
143Cholinergic synapse_Homo sapiens_hsa047250.05879704
144Basal cell carcinoma_Homo sapiens_hsa052170.05354676
145Vascular smooth muscle contraction_Homo sapiens_hsa042700.05195902
146Dopaminergic synapse_Homo sapiens_hsa047280.04896748
147Serotonergic synapse_Homo sapiens_hsa047260.04463931
148MAPK signaling pathway_Homo sapiens_hsa040100.04371617
149Cocaine addiction_Homo sapiens_hsa050300.04260591
150Galactose metabolism_Homo sapiens_hsa000520.04172060
151Fatty acid biosynthesis_Homo sapiens_hsa000610.04122343

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