BPIFA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.99981750
2epithelial cilium movement (GO:0003351)9.78311037
3plasma membrane fusion (GO:0045026)9.71661257
4axonemal dynein complex assembly (GO:0070286)9.50484255
5motile cilium assembly (GO:0044458)9.32452098
6reproduction (GO:0000003)9.12456305
7regulation of cilium movement (GO:0003352)8.77782386
8response to pheromone (GO:0019236)8.10770643
9negative regulation of inclusion body assembly (GO:0090084)7.87036942
10cilium movement (GO:0003341)7.81281623
11cilium or flagellum-dependent cell motility (GO:0001539)7.77015252
12sperm capacitation (GO:0048240)7.32883799
13single fertilization (GO:0007338)7.19010250
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.08596076
15organic cation transport (GO:0015695)7.06794971
16phosphatidylethanolamine biosynthetic process (GO:0006646)7.06049967
17spermatogenesis (GO:0007283)6.99459837
18male gamete generation (GO:0048232)6.96805824
19protein targeting to Golgi (GO:0000042)6.94197718
20synaptonemal complex organization (GO:0070193)6.93806127
21synaptonemal complex assembly (GO:0007130)6.82575578
22microtubule depolymerization (GO:0007019)6.72511933
23establishment of protein localization to Golgi (GO:0072600)6.72243341
24rRNA methylation (GO:0031167)6.68974654
25male meiosis (GO:0007140)6.53102972
26phosphatidylethanolamine metabolic process (GO:0046337)6.50598569
27retrograde transport, vesicle recycling within Golgi (GO:0000301)6.50536006
28regulation of inclusion body assembly (GO:0090083)6.45853162
29gamete generation (GO:0007276)6.40174548
30piRNA metabolic process (GO:0034587)6.28718941
31fertilization (GO:0009566)6.12800089
32centriole replication (GO:0007099)6.04924123
33chromosome condensation (GO:0030261)5.91040423
34calcium ion-dependent exocytosis (GO:0017156)5.87237331
35DNA packaging (GO:0006323)5.60534950
36rRNA modification (GO:0000154)5.58234143
37germ cell development (GO:0007281)5.49020988
38positive regulation of Rab GTPase activity (GO:0032851)5.46188473
39regulation of Rab GTPase activity (GO:0032313)5.46188473
40cellular process involved in reproduction in multicellular organism (GO:0022412)5.38914193
41glycerol ether metabolic process (GO:0006662)5.37915288
42spermatid nucleus differentiation (GO:0007289)5.36938483
43centriole assembly (GO:0098534)5.24822416
44regulation of microtubule-based movement (GO:0060632)5.14787182
45regulation of transcription involved in cell fate commitment (GO:0060850)5.14747040
46cellular ketone body metabolic process (GO:0046950)5.07798061
47cell recognition (GO:0008037)5.04892945
48multicellular organismal reproductive process (GO:0048609)5.04276256
49ventricular system development (GO:0021591)5.02854659
50sexual reproduction (GO:0019953)5.01483122
51regulation of centriole replication (GO:0046599)4.97739918
52ether metabolic process (GO:0018904)4.96967029
53protein localization to Golgi apparatus (GO:0034067)4.91515235
54microtubule severing (GO:0051013)4.69155432
55seminiferous tubule development (GO:0072520)4.59739040
56single strand break repair (GO:0000012)4.58483619
57chromosome organization involved in meiosis (GO:0070192)4.55395982
58male meiosis I (GO:0007141)4.51276233
59ketone body metabolic process (GO:1902224)4.47520336
60left/right pattern formation (GO:0060972)4.34141842
61DNA methylation involved in gamete generation (GO:0043046)4.10645126
62multicellular organismal movement (GO:0050879)4.10296329
63musculoskeletal movement (GO:0050881)4.10296329
64multicellular organismal development (GO:0007275)4.08414726
65chaperone-mediated protein complex assembly (GO:0051131)4.07978083
66meiotic nuclear division (GO:0007126)3.91251680
67response to acidic pH (GO:0010447)3.72397755
68peptidyl-threonine dephosphorylation (GO:0035970)3.67877805
69sequestering of actin monomers (GO:0042989)3.66982179
70protein polyglutamylation (GO:0018095)3.66468075
71antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.61381194
72cerebral cortex neuron differentiation (GO:0021895)3.60913380
73meiosis I (GO:0007127)3.57192879
74Golgi to endosome transport (GO:0006895)3.56550480
75microtubule polymerization or depolymerization (GO:0031109)3.46821795
76genitalia morphogenesis (GO:0035112)3.43466070
77cellular response to pH (GO:0071467)3.42713399
78microtubule nucleation (GO:0007020)3.42186964
79protein K11-linked deubiquitination (GO:0035871)3.42040974
80regulation of spindle checkpoint (GO:0090231)3.39535669
81cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.38097655
82negative regulation of Rho protein signal transduction (GO:0035024)3.37789886
83protein refolding (GO:0042026)3.37754456
84RNA localization (GO:0006403)3.36111922
85nucleus organization (GO:0006997)3.34821215
86homeostasis of number of cells within a tissue (GO:0048873)3.32359110
87regulation of interleukin-13 production (GO:0032656)3.28305792
88glycolytic process (GO:0006096)3.28217351
89coenzyme catabolic process (GO:0009109)3.25781770
90histone H3-K9 demethylation (GO:0033169)3.25268093
91polyamine biosynthetic process (GO:0006596)3.17575521
92regulation of T-helper 2 cell differentiation (GO:0045628)3.17143130
93meiotic cell cycle (GO:0051321)3.15470816
94mitotic sister chromatid cohesion (GO:0007064)3.11609047
95interferon-gamma secretion (GO:0072643)3.11008085
96RNA destabilization (GO:0050779)3.09361717
97positive regulation of macrophage activation (GO:0043032)3.05621869
98nucleoside diphosphate phosphorylation (GO:0006165)3.03520387
99amino-acid betaine transport (GO:0015838)3.02428230
100carnitine transport (GO:0015879)3.02428230
101positive regulation of guanylate cyclase activity (GO:0031284)3.02315356
102regulation of somitogenesis (GO:0014807)3.01447761
103chromatin silencing (GO:0006342)3.00516099
104mitotic G1 DNA damage checkpoint (GO:0031571)2.97043698
105polyol catabolic process (GO:0046174)2.96283127
106regulation of guanylate cyclase activity (GO:0031282)2.94429316
107protein depolymerization (GO:0051261)2.93110220
108regulation of phosphoprotein phosphatase activity (GO:0043666)2.88025976
109protein localization to cilium (GO:0061512)2.87930108
110mitochondrial fission (GO:0000266)2.87665121
111negative regulation of gene expression, epigenetic (GO:0045814)2.85603657
112alditol metabolic process (GO:0019400)2.82842036
113carnitine transmembrane transport (GO:1902603)2.81398933
114centrosome duplication (GO:0051298)2.80436006
115monoubiquitinated protein deubiquitination (GO:0035520)2.80124862
116lactate metabolic process (GO:0006089)2.79875477
117positive regulation of endothelial cell differentiation (GO:0045603)2.78041445
118DNA conformation change (GO:0071103)2.75217208
119vesicle transport along microtubule (GO:0047496)2.73854305
120regulation of cilium assembly (GO:1902017)2.71934792
121receptor recycling (GO:0001881)2.70367952
122mitochondrion degradation (GO:0000422)2.68987842
123cilium organization (GO:0044782)2.68387620
124GTP biosynthetic process (GO:0006183)2.67640663
125meiotic cell cycle process (GO:1903046)2.62682445
126cilium assembly (GO:0042384)2.58758406
127positive regulation of glycolytic process (GO:0045821)2.57428788
128synapsis (GO:0007129)2.55669153
129microtubule-based movement (GO:0007018)2.55122887
130protein-DNA complex disassembly (GO:0032986)2.55027892
131nucleosome disassembly (GO:0006337)2.55027892
132cellular component assembly involved in morphogenesis (GO:0010927)2.54367887
133peptidyl-glutamic acid modification (GO:0018200)2.53734943
134cilium morphogenesis (GO:0060271)2.48260962
135membrane protein intracellular domain proteolysis (GO:0031293)2.48193373
136calcium ion import (GO:0070509)2.42902041
137sperm motility (GO:0030317)14.7100706
138cell wall macromolecule catabolic process (GO:0016998)13.0350907
139cell wall macromolecule metabolic process (GO:0044036)13.0350907
140acrosome reaction (GO:0007340)12.8337939
141fusion of sperm to egg plasma membrane (GO:0007342)12.6920632
142sperm-egg recognition (GO:0035036)11.5204756
143acrosome assembly (GO:0001675)11.0959573
144binding of sperm to zona pellucida (GO:0007339)10.6129791
145cell-cell recognition (GO:0009988)10.3113133
146multicellular organism reproduction (GO:0032504)10.2987721

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.44663898
2EZH2_22144423_ChIP-Seq_EOC_Human5.21783964
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.44329499
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.86886847
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.29123843
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.28573449
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.15371696
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.77498026
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.67895138
10VDR_22108803_ChIP-Seq_LS180_Human2.60194579
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.52530693
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.20131336
13VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.16870647
14CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.14263160
15DROSHA_22980978_ChIP-Seq_HELA_Human2.10368394
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08350918
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04239731
18ZNF274_21170338_ChIP-Seq_K562_Hela1.94248261
19EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.94062463
20EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.86850527
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.84844404
22ERA_21632823_ChIP-Seq_H3396_Human1.82166046
23NANOG_20526341_ChIP-Seq_ESCs_Human1.80123967
24RAC3_21632823_ChIP-Seq_H3396_Human1.77445954
25FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77172200
26MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.73753631
27* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.73172775
28ELK4_26923725_Chip-Seq_MESODERM_Mouse1.69227413
29BCL6_27268052_Chip-Seq_Bcells_Human1.67636190
30FUS_26573619_Chip-Seq_HEK293_Human1.67569815
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.67107983
32KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.65651178
33STAT1_17558387_ChIP-Seq_HELA_Human1.64471492
34TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.62165106
35SMC4_20622854_ChIP-Seq_HELA_Human1.61004689
36SOX2_22085726_ChIP-Seq_NPCs_Mouse1.60828824
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57749803
38TAF2_19829295_ChIP-Seq_ESCs_Human1.57699881
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57606379
40ER_23166858_ChIP-Seq_MCF-7_Human1.56507905
41E2F1_20622854_ChIP-Seq_HELA_Human1.54801230
42TDRD3_21172665_ChIP-Seq_MCF-7_Human1.54412433
43MYC_19829295_ChIP-Seq_ESCs_Human1.52043902
44GATA3_21867929_ChIP-Seq_CD8_Mouse1.51667395
45REST_21632747_ChIP-Seq_MESCs_Mouse1.51076290
46ARNT_22903824_ChIP-Seq_MCF-7_Human1.50799113
47P68_20966046_ChIP-Seq_HELA_Human1.50459747
48AUTS2_25519132_ChIP-Seq_293T-REX_Human1.50299758
49PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.50182311
50PHF8_20622854_ChIP-Seq_HELA_Human1.49097234
51FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.48898033
52KDM2B_26808549_Chip-Seq_REH_Human1.47528766
53OCT4_20526341_ChIP-Seq_ESCs_Human1.47166957
54PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.45103406
55GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.44906877
56WDR5_24793694_ChIP-Seq_LNCAP_Human1.44613206
57AR_25329375_ChIP-Seq_VCAP_Human1.43642505
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42905840
59TAL1_26923725_Chip-Seq_HPCs_Mouse1.41474670
60SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41099835
61TP63_22573176_ChIP-Seq_HFKS_Human1.40896083
62P300_27268052_Chip-Seq_Bcells_Human1.39638471
63P53_21459846_ChIP-Seq_SAOS-2_Human1.36658526
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35986085
65SMAD3_21741376_ChIP-Seq_ESCs_Human1.33899918
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33833317
67CBP_20019798_ChIP-Seq_JUKART_Human1.33833317
68SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.32670405
69LXR_22292898_ChIP-Seq_THP-1_Human1.32439281
70RBPJ_21746931_ChIP-Seq_IB4_Human1.32246073
71HNFA_21074721_ChIP-Seq_CACO-2_Human1.30781030
72CBX2_22325352_ChIP-Seq_293T-Rex_Human1.30719377
73RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.30618941
74CEBPB_22108803_ChIP-Seq_LS180_Human1.29588654
75AR_21572438_ChIP-Seq_LNCaP_Human1.29561609
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29496748
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29496748
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29468188
79P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.28281903
80CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.28226989
81KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.27661910
82CBX2_27304074_Chip-Seq_ESCs_Mouse1.26428090
83LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.26043780
84ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25740371
85CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25120391
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.24255423
87GF1_26923725_Chip-Seq_HPCs_Mouse1.23862013
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23134160
89GATA3_21867929_ChIP-Seq_TH1_Mouse1.21471832
90GATA3_21878914_ChIP-Seq_MCF-7_Human1.21348952
91RAD21_21589869_ChIP-Seq_MESCs_Mouse1.20526118
92SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20120599
93TP53_18474530_ChIP-ChIP_U2OS_Human1.20003555
94P300_19829295_ChIP-Seq_ESCs_Human1.18158593
95SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17880937
96FLI1_21867929_ChIP-Seq_TH2_Mouse1.17638540
97CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17443878
98KAP1_22055183_ChIP-Seq_ESCs_Mouse1.16795123
99CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16633313
100PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16471549
101SMRT_27268052_Chip-Seq_Bcells_Human1.16446836
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15402102
103SPI1_26923725_Chip-Seq_HPCs_Mouse1.13977379
104DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13930013
105MYC_27129775_Chip-Seq_CORNEA_Mouse1.13835819
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13325508
107RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12872220
108NFE2_27457419_Chip-Seq_LIVER_Mouse1.11232806
109RUNX1_26923725_Chip-Seq_HPCs_Mouse1.10610336
110NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10586425
111RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10533228
112TET1_21451524_ChIP-Seq_MESCs_Mouse1.10110690
113TAF15_26573619_Chip-Seq_HEK293_Human1.08920638
114SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08507336
115PHF8_20622853_ChIP-Seq_HELA_Human1.08423162
116TP63_19390658_ChIP-ChIP_HaCaT_Human1.08069764
117PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07536238
118EZH2_27294783_Chip-Seq_ESCs_Mouse1.07190384
119GATA1_19941827_ChIP-Seq_MEL86_Mouse1.07048797
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06680704
121GATA6_21074721_ChIP-Seq_CACO-2_Human1.06591393
122SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.06462685
123EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06249025
124EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.05896740
125RUNX_20019798_ChIP-Seq_JUKART_Human1.05871007
126SMAD4_21741376_ChIP-Seq_HESCs_Human1.05131000
127NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04553152
128ERG_20517297_ChIP-Seq_VCAP_Human1.04514647
129SA1_27219007_Chip-Seq_Bcells_Human1.04422061
130NFYA_21822215_ChIP-Seq_K562_Human1.03148029
131JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.03067233
132OCT1_27270436_Chip-Seq_PROSTATE_Human1.02585908
133CTCF_20526341_ChIP-Seq_ESCs_Human1.01612237
134RUNX2_22187159_ChIP-Seq_PCA_Human1.01594401
135YY1_22570637_ChIP-Seq_MALME-3M_Human1.01405925
136KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01228329
137PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01190884
138NANOG_19829295_ChIP-Seq_ESCs_Human1.01045053
139SOX2_19829295_ChIP-Seq_ESCs_Human1.01045053
140STAT3_23295773_ChIP-Seq_U87_Human1.00912595
141GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00743942
142RARA_24833708_ChIP-Seq_LIVER_Mouse0.99957868
143ESET_19884257_ChIP-Seq_ESCs_Mouse0.99843145
144NANOG_18555785_Chip-Seq_ESCs_Mouse0.99232761
145CTCF_27219007_Chip-Seq_Bcells_Human0.98647400
146PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98430603
147SOX11_22085726_ChIP-Seq_ESNs_Mouse0.97934799
148SUZ12_27294783_Chip-Seq_ESCs_Mouse0.97925986
149SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97715282
150PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97129716
151NFYB_21822215_ChIP-Seq_K562_Human0.96803477
152SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96716383
153BCOR_27268052_Chip-Seq_Bcells_Human0.93897303
154ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93616519
155CRX_20693478_ChIP-Seq_RETINA_Mouse0.93556090
156SOX9_26525672_Chip-Seq_HEART_Mouse0.93053010
157TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91958559
158ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90700165
159TBL1_22424771_ChIP-Seq_293T_Human0.90360228
160SMAD4_21741376_ChIP-Seq_EPCs_Human0.90201007
161ETV1_20927104_ChIP-Seq_GIST48_Human0.89507862
162CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89379087
163FLI1_21867929_ChIP-Seq_CD8_Mouse0.88999754
164P53_22387025_ChIP-Seq_ESCs_Mouse0.88164773
165ELF1_20517297_ChIP-Seq_JURKAT_Human0.86943632
166LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.85862129
167OCT4_18555785_Chip-Seq_ESCs_Mouse0.85821682

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.96390309
2MP0001929_abnormal_gametogenesis5.38592138
3MP0008877_abnormal_DNA_methylation3.58931737
4MP0005670_abnormal_white_adipose3.36897605
5MP0001348_abnormal_lacrimal_gland3.33943502
6MP0002161_abnormal_fertility/fecundity3.28357268
7MP0002210_abnormal_sex_determination3.10935014
8MP0001145_abnormal_male_reproductive2.63484030
9MP0002653_abnormal_ependyma_morphology2.34715743
10MP0000653_abnormal_sex_gland2.28613604
11MP0000678_abnormal_parathyroid_gland2.25061742
12MP0003718_maternal_effect2.24133740
13MP0005410_abnormal_fertilization16.6439385
14MP0002822_catalepsy1.98331844
15MP0002132_abnormal_respiratory_system1.83960583
16MP0005379_endocrine/exocrine_gland_phen1.72798604
17MP0001485_abnormal_pinna_reflex1.65022179
18MP0004233_abnormal_muscle_weight1.63926753
19MP0005451_abnormal_body_composition1.57325632
20MP0005310_abnormal_salivary_gland1.42937011
21MP0009053_abnormal_anal_canal1.42632326
22MP0002249_abnormal_larynx_morphology1.42229584
23MP0001486_abnormal_startle_reflex1.39316228
24MP0003646_muscle_fatigue1.35459388
25MP0002160_abnormal_reproductive_system1.32140919
26MP0002138_abnormal_hepatobiliary_system1.31192729
27MP0001765_abnormal_ion_homeostasis1.29860961
28MP0005377_hearing/vestibular/ear_phenot1.10436548
29MP0003878_abnormal_ear_physiology1.10436548
30MP0001963_abnormal_hearing_physiology1.08758961
31MP0004742_abnormal_vestibular_system1.08681888
32MP0005623_abnormal_meninges_morphology1.06196919
33MP0005395_other_phenotype0.99922062
34MP0002127_abnormal_cardiovascular_syste0.98431143
35MP0008995_early_reproductive_senescence0.97688339
36MP0002282_abnormal_trachea_morphology0.95952473
37MP0000026_abnormal_inner_ear0.94294513
38MP0001984_abnormal_olfaction0.93780080
39MP0004510_myositis0.92722217
40MP0005083_abnormal_biliary_tract0.91841383
41MP0005666_abnormal_adipose_tissue0.91193951
42MP0002234_abnormal_pharynx_morphology0.87055059
43MP0000955_abnormal_spinal_cord0.86616922
44MP0001905_abnormal_dopamine_level0.86255218
45MP0005248_abnormal_Harderian_gland0.83505033
46MP0003329_amyloid_beta_deposits0.82304952
47MP0009046_muscle_twitch0.81322564
48MP0002067_abnormal_sensory_capabilities0.79990708
49MP0002736_abnormal_nociception_after0.75933107
50MP0009697_abnormal_copulation0.74288272
51MP0002557_abnormal_social/conspecific_i0.70238443
52MP0005167_abnormal_blood-brain_barrier0.69920188
53MP0003115_abnormal_respiratory_system0.69448615
54MP0005636_abnormal_mineral_homeostasis0.69444464
55MP0005647_abnormal_sex_gland0.67895226
56MP0004085_abnormal_heartbeat0.67528015
57MP0001545_abnormal_hematopoietic_system0.67329638
58MP0005397_hematopoietic_system_phenotyp0.67329638
59MP0005389_reproductive_system_phenotype0.66309726
60MP0000681_abnormal_thyroid_gland0.65080077
61MP0002733_abnormal_thermal_nociception0.63911840
62MP0001666_abnormal_nutrient_absorption0.59875951
63MP0000049_abnormal_middle_ear0.56173143
64MP0002269_muscular_atrophy0.55484769
65MP0003879_abnormal_hair_cell0.54376913
66MP0004484_altered_response_of0.54195972
67MP0001879_abnormal_lymphatic_vessel0.53411222
68MP0005535_abnormal_body_temperature0.53322960
69MP0008058_abnormal_DNA_repair0.53271874
70MP0003011_delayed_dark_adaptation0.52667772
71MP0001968_abnormal_touch/_nociception0.51909449
72MP0003699_abnormal_female_reproductive0.50537899
73MP0000516_abnormal_urinary_system0.50059776
74MP0005367_renal/urinary_system_phenotyp0.50059776
75MP0000003_abnormal_adipose_tissue0.48898242
76MP0008961_abnormal_basal_metabolism0.48858135
77MP0001849_ear_inflammation0.48351428
78MP0003137_abnormal_impulse_conducting0.48108687
79MP0001501_abnormal_sleep_pattern0.47757098
80MP0003077_abnormal_cell_cycle0.47499415
81MP0000751_myopathy0.47289570
82MP0000249_abnormal_blood_vessel0.47006644
83MP0002734_abnormal_mechanical_nocicepti0.46293721
84MP0009764_decreased_sensitivity_to0.46094051
85MP0001970_abnormal_pain_threshold0.45162953
86MP0004133_heterotaxia0.44430038
87MP0010329_abnormal_lipoprotein_level0.44044241
88MP0000230_abnormal_systemic_arterial0.44036196
89MP0001324_abnormal_eye_pigmentation0.43785983
90MP0001764_abnormal_homeostasis0.43050055
91MP0004859_abnormal_synaptic_plasticity0.41948162
92MP0000358_abnormal_cell_content/0.41854161
93MP0002063_abnormal_learning/memory/cond0.41730220
94MP0000604_amyloidosis0.41377187
95MP0000470_abnormal_stomach_morphology0.41159046
96MP0003635_abnormal_synaptic_transmissio0.40962419
97MP0005085_abnormal_gallbladder_physiolo0.40942533
98MP0009278_abnormal_bone_marrow0.40933645
99MP0005423_abnormal_somatic_nervous0.40582547
100MP0004036_abnormal_muscle_relaxation0.39826914
101MP0005551_abnormal_eye_electrophysiolog0.39315491
102MP0002295_abnormal_pulmonary_circulatio0.39066360
103MP0004084_abnormal_cardiac_muscle0.38072973
104MP0003119_abnormal_digestive_system0.37844072
105MP0000534_abnormal_ureter_morphology0.37306946
106MP0004811_abnormal_neuron_physiology0.36684775
107MP0009115_abnormal_fat_cell0.36665844
108MP0001440_abnormal_grooming_behavior0.35856254
109MP0000613_abnormal_salivary_gland0.35210756
110MP0003959_abnormal_lean_body0.34312618
111MP0001270_distended_abdomen0.33903503
112MP0003633_abnormal_nervous_system0.33848724
113MP0005375_adipose_tissue_phenotype0.33783036
114MP0003942_abnormal_urinary_system0.33781285
115MP0002928_abnormal_bile_duct0.32483927
116MP0005253_abnormal_eye_physiology0.31886257
117MP0003631_nervous_system_phenotype0.31529465
118MP0000569_abnormal_digit_pigmentation0.31268728
119MP0002572_abnormal_emotion/affect_behav0.31177733
120MP0004270_analgesia0.31103064
121MP0003861_abnormal_nervous_system0.31024740
122MP0002152_abnormal_brain_morphology0.30684122
123MP0009745_abnormal_behavioral_response0.29687768
124MP0006036_abnormal_mitochondrial_physio0.29566048
125MP0010094_abnormal_chromosome_stability0.29382812
126MP0003787_abnormal_imprinting0.29098583
127MP0002169_no_abnormal_phenotype0.27778850
128MP0003111_abnormal_nucleus_morphology0.27605176
129MP0008569_lethality_at_weaning0.27577231
130MP0002873_normal_phenotype0.27560523
131MP0004145_abnormal_muscle_electrophysio0.27507522
132MP0002971_abnormal_brown_adipose0.27326149
133MP0001293_anophthalmia0.27021584
134MP0008770_decreased_survivor_rate0.25564240
135MP0003950_abnormal_plasma_membrane0.25543071
136MP0000749_muscle_degeneration0.22527804
137MP0004808_abnormal_hematopoietic_stem0.21290993
138MP0006035_abnormal_mitochondrial_morpho0.21217558
139MP0005391_vision/eye_phenotype0.21125484
140MP0002272_abnormal_nervous_system0.21096533
141MP0003948_abnormal_gas_homeostasis0.19764414
142MP0005319_abnormal_enzyme/_coenzyme0.19406862
143MP0003632_abnormal_nervous_system0.19285962
144MP0000920_abnormal_myelination0.17606969
145MP0000001_mammalian_phenotype0.16909757
146MP0004019_abnormal_vitamin_homeostasis0.16837621
147MP0008875_abnormal_xenobiotic_pharmacok0.16223479
148MP0001119_abnormal_female_reproductive0.16157575
149MP0002229_neurodegeneration0.15868496
150MP0002106_abnormal_muscle_physiology0.15706526
151MP0002882_abnormal_neuron_morphology0.15099187
152MP0002139_abnormal_hepatobiliary_system0.15011453
153MP0002735_abnormal_chemical_nociception0.14979239
154MP0000462_abnormal_digestive_system0.13949997

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.29270417
2Abnormal respiratory motile cilium morphology (HP:0005938)9.29270417
3Abnormal respiratory motile cilium physiology (HP:0012261)9.14095066
4Severe visual impairment (HP:0001141)8.04136408
5Rhinitis (HP:0012384)7.23299986
6Chronic bronchitis (HP:0004469)7.19467328
7Infertility (HP:0000789)7.07360786
8Abnormal ciliary motility (HP:0012262)7.05785696
9Nasal polyposis (HP:0100582)6.25288718
10Abnormality of the nasal mucosa (HP:0000433)5.14758845
11Attenuation of retinal blood vessels (HP:0007843)5.08834686
12Male infertility (HP:0003251)5.07358686
13Chronic hepatic failure (HP:0100626)4.99058677
14Bony spicule pigmentary retinopathy (HP:0007737)4.97308371
15Bronchitis (HP:0012387)4.49509681
16Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.46963741
17Resting tremor (HP:0002322)4.45226658
18Bronchiectasis (HP:0002110)4.26473577
19Hypoplastic ischia (HP:0003175)4.14303687
20Abnormality of macular pigmentation (HP:0008002)4.11196964
21Potter facies (HP:0002009)4.07071982
22Facial shape deformation (HP:0011334)4.07071982
23Nephronophthisis (HP:0000090)4.06840667
24Cone-rod dystrophy (HP:0000548)3.90716924
25Abnormal spermatogenesis (HP:0008669)3.78251125
26Abnormal rod and cone electroretinograms (HP:0008323)3.75313280
27Abnormality of the ischium (HP:0003174)3.74100033
28Aplasia/Hypoplasia of the earlobes (HP:0009906)3.63209979
29Hypoplasia of the thymus (HP:0000778)3.52015258
30Enlarged epiphyses (HP:0010580)3.43087566
31Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.29509984
32Hypoalphalipoproteinemia (HP:0003233)3.23722997
33Postural instability (HP:0002172)3.20831876
34Recurrent otitis media (HP:0000403)3.20750996
35Recurrent sinusitis (HP:0011108)3.09634152
36Progressive sensorineural hearing impairment (HP:0000408)3.06896617
37Abnormality of the renal medulla (HP:0100957)3.03205415
38Impulsivity (HP:0100710)2.85508315
39Amelogenesis imperfecta (HP:0000705)2.85379753
40Renovascular hypertension (HP:0100817)2.73592994
41Generalized aminoaciduria (HP:0002909)2.72585016
42Portal hypertension (HP:0001409)2.72526956
43Abnormality of potassium homeostasis (HP:0011042)2.72371259
44Menstrual irregularities (HP:0000858)2.71860126
45Recurrent bronchitis (HP:0002837)2.69537915
46Tubulointerstitial nephritis (HP:0001970)2.67134292
47Abnormality of the costochondral junction (HP:0000919)2.64149515
48Tubular atrophy (HP:0000092)2.63172690
49Abnormal gallbladder physiology (HP:0012438)2.62584244
50Cholecystitis (HP:0001082)2.62584244
51Choroideremia (HP:0001139)2.57787393
52Abnormality of dental color (HP:0011073)2.54708065
53Insulin-resistant diabetes mellitus (HP:0000831)2.51466956
54Unilateral renal agenesis (HP:0000122)2.49565395
55Abnormality of the hepatic vasculature (HP:0006707)2.48696225
56Abnormality of the aortic arch (HP:0012303)2.45368034
57Epiphyseal dysplasia (HP:0002656)2.43905693
58Tubulointerstitial abnormality (HP:0001969)2.42087379
59Molar tooth sign on MRI (HP:0002419)2.37485863
60Abnormality of midbrain morphology (HP:0002418)2.37485863
61Dyschromatopsia (HP:0007641)2.35204364
62Ventricular tachycardia (HP:0004756)2.32438828
63Azoospermia (HP:0000027)2.24225299
64Hypophosphatemic rickets (HP:0004912)2.23354726
65Gonadotropin excess (HP:0000837)2.19883958
66Medial flaring of the eyebrow (HP:0010747)2.14904832
67Widely patent fontanelles and sutures (HP:0004492)2.11797206
68Abnormality of the pubic bones (HP:0003172)2.07363077
69Abnormality of the parathyroid morphology (HP:0011766)2.07223569
70Double outlet right ventricle (HP:0001719)2.06598535
71Congenital malformation of the right heart (HP:0011723)2.06598535
72Tubulointerstitial fibrosis (HP:0005576)2.06184376
73Decreased central vision (HP:0007663)2.02691863
74Osteomalacia (HP:0002749)2.02642138
75Recurrent pneumonia (HP:0006532)2.02579577
76Increased purine levels (HP:0004368)2.02430793
77Hyperuricemia (HP:0002149)2.02430793
78Spastic tetraparesis (HP:0001285)2.00736200
79Absent/shortened dynein arms (HP:0200106)13.3750354
80Dynein arm defect of respiratory motile cilia (HP:0012255)13.3750354
81Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.6792782
82Intellectual disability, moderate (HP:0002342)1.93103603
83Progressive hearing impairment (HP:0001730)1.93016119
84Optic nerve hypoplasia (HP:0000609)1.91555713
85Flattened epiphyses (HP:0003071)1.91379187
86Hyponatremia (HP:0002902)1.90268641
87Abnormal drinking behavior (HP:0030082)1.89793519
88Polydipsia (HP:0001959)1.89793519
89Abnormality of the epiphysis of the femoral head (HP:0010574)1.88249257
90Hemorrhage of the eye (HP:0011885)1.86345858
91Myokymia (HP:0002411)1.81737088
92Hyperkalemia (HP:0002153)1.80694631
93Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79550990
94Abnormal biliary tract physiology (HP:0012439)1.76814309
95Bile duct proliferation (HP:0001408)1.76814309
96Subcapsular cataract (HP:0000523)1.76728956
97Spastic paraparesis (HP:0002313)1.75963636
98Abnormality of femoral epiphyses (HP:0006499)1.75495891
99Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.75495891
100Anterior segment dysgenesis (HP:0007700)1.75002968
101Upper limb muscle weakness (HP:0003484)1.74877057
102Transposition of the great arteries (HP:0001669)1.74770818
103Abnormal connection of the cardiac segments (HP:0011545)1.74770818
104Abnormal ventriculo-arterial connection (HP:0011563)1.74770818
105Aplasia/Hypoplasia of the sacrum (HP:0008517)1.73580412
106Neurofibrillary tangles (HP:0002185)1.72119280
107Tetany (HP:0001281)1.71323895
108Photophobia (HP:0000613)1.71163728
109Stage 5 chronic kidney disease (HP:0003774)1.70930219
110Abnormality of renal excretion (HP:0011036)1.66937360
111Heterotopia (HP:0002282)1.64725502
112Exercise-induced myalgia (HP:0003738)1.64266237
113Postaxial foot polydactyly (HP:0001830)1.63125100
114Congenital hepatic fibrosis (HP:0002612)1.60899468
115Abnormality of the renal cortex (HP:0011035)1.58910241
116Bell-shaped thorax (HP:0001591)1.58205917
117Hypoplasia of the capital femoral epiphysis (HP:0003090)1.54970839
118Aplasia/Hypoplasia of the lens (HP:0008063)1.54291204
119Asymmetric septal hypertrophy (HP:0001670)1.51312274
120Short ribs (HP:0000773)1.50398121
121Abnormal urine output (HP:0012590)1.47584986
122Bundle branch block (HP:0011710)1.46132604
123Hemiparesis (HP:0001269)1.44987055
124Abnormality of dentin (HP:0010299)1.44236338
125Progressive cerebellar ataxia (HP:0002073)1.44062653
126Hypercholesterolemia (HP:0003124)1.43553838
127Cerebral inclusion bodies (HP:0100314)1.39120358
128Oculomotor apraxia (HP:0000657)1.38499666
129Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.38299108
130Abnormality of permanent molar morphology (HP:0011071)1.37714161
131Abnormality of the dental root (HP:0006486)1.37714161
132Taurodontia (HP:0000679)1.37714161
133Myoglobinuria (HP:0002913)1.36878527
134Sensory axonal neuropathy (HP:0003390)1.35715082
135Easy fatigability (HP:0003388)1.32451694
136Abnormality of the neuromuscular junction (HP:0003398)1.30103723
137Fatigable weakness (HP:0003473)1.30103723
138Constricted visual fields (HP:0001133)1.29789106
139Postaxial hand polydactyly (HP:0001162)1.29623216
140Cerebellar dysplasia (HP:0007033)1.29348485
141Truncal obesity (HP:0001956)1.28886255
142Abnormality of the dental pulp (HP:0006479)1.28516191
143Renal dysplasia (HP:0000110)1.27562501
144Retinal dysplasia (HP:0007973)1.27388164
145Abnormality of molar morphology (HP:0011070)1.27265523
146Abnormality of molar (HP:0011077)1.27265523
147Cystic liver disease (HP:0006706)1.25824205
148Abnormality of saccadic eye movements (HP:0000570)1.25066010
149Abnormality of the lower motor neuron (HP:0002366)1.24333483
150Hyporeflexia of lower limbs (HP:0002600)1.23912694
151Loss of speech (HP:0002371)1.23877525
152EMG: neuropathic changes (HP:0003445)1.22410373
153Deformed sella turcica (HP:0002681)1.22048308
154Polyuria (HP:0000103)1.20761126
155Generalized muscle weakness (HP:0003324)1.20634721
156Absent epiphyses (HP:0010577)1.20188675
157Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.20188675
158Retinal atrophy (HP:0001105)1.18629451
159Rhabdomyolysis (HP:0003201)1.18361002
160Fibular hypoplasia (HP:0003038)1.18313798
161Chronic sinusitis (HP:0011109)1.18240401

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.74336139
2PDK47.74336139
3TESK16.94286688
4PRKD35.54884713
5PDK24.99343144
6ICK4.92932845
7DDR24.92020833
8INSRR3.17390688
9BRD42.78973246
10MAP4K22.41659192
11PTK2B2.11562828
12WNK41.95437894
13STK381.92372801
14MST1R1.91809644
15STK391.87203937
16DYRK1B1.75964959
17PIK3CG1.72421729
18PNCK1.58609568
19NEK21.41089230
20PDK11.28320032
21CDK71.24961779
22CDK121.24929030
23CAMK1D1.03888232
24MARK20.99449636
25AKT30.97008905
26KSR20.92232045
27SIK20.87097504
28PDPK10.84644736
29IRAK10.84624987
30MAPK150.81204994
31RIPK40.79605034
32DYRK30.79156827
33MAP3K110.78795562
34RPS6KA20.76622365
35ARAF0.75331542
36TYRO30.74000170
37WNK10.72203964
38MAP3K90.69976189
39MAP2K60.69647114
40PASK0.69435153
41CHEK20.66118348
42LATS20.65477374
43NTRK20.65475989
44UHMK10.65454032
45MAP3K20.64746051
46PINK10.64242542
47MAP2K20.63659648
48TTK0.63469453
49EEF2K0.62060510
50CAMK10.55066643
51STK30.54337372
52CCNB10.53863674
53ROCK10.53426167
54IRAK20.51347016
55TESK20.50824707
56PRKCG0.49116374
57FRK0.47307326
58RPS6KA60.46799716
59MAP3K80.45588166
60EPHA40.44017314
61RPS6KL10.43784212
62RPS6KC10.43784212
63MUSK0.42392170
64BMPR1B0.42103851
65CDK30.41284570
66SGK4940.40965924
67SGK2230.40965924
68CAMK1G0.40534647
69JAK30.40423648
70PAK10.40102245
71MAP3K100.39839321
72MAPK10.39593187
73ZAK0.37284645
74OXSR10.37244160
75LMTK20.34991666
76CHEK10.30870081
77MET0.30658563
78CAMK40.30634136
79STK38L0.30461549
80MAP3K10.29701087
81CDK40.28284193
82ADRBK20.27812186
83MAPK110.27596595
84MARK10.26510709
85SGK10.26319919
86PAK40.26016580
87MAPK100.24594491
88PAK20.24124712
89RPS6KB10.23301286
90ATM0.22964320
91PRKCZ0.22905280
92MAPKAPK50.22775355
93MAPK140.22727700
94PRKCQ0.21855728
95MTOR0.21825001
96CDK150.21707920
97CAMKK10.21230976
98MAP3K40.21219595
99BRAF0.21049350
100NEK60.19577051
101TIE10.18646143
102CDK180.18631756
103ATR0.17300931
104ACVR1B0.16986711
105CDK11A0.16484453
106BMX0.16361080
107MARK30.16277419
108AKT10.15800299
109PRKAA10.15595506
110NTRK30.15298966
111CAMK2A0.13714369
112CDK190.13675171
113PRKAA20.13191275
114FER0.12190919
115CDK140.11861070
116PRKCE0.11181794
117BRSK20.10733986
118PLK20.10257885
119GSK3B0.09041851
120CLK10.08858915
121MAPK80.08111376
122SGK20.07260838
123TNIK0.06925727
124BRSK10.06416792
125PRKCA0.06227442
126PRKG20.06121367
127PRKACB0.05369318
128EPHB10.05366577
129PLK10.05237289
130PRKG10.05131218
131RPS6KA10.04753929
132CSNK1G20.04602590
133IGF1R0.04342188
134STK110.04209356
135PKN10.04030059
136CSNK2A10.03629980
137PRKCB0.03581834
138CSNK1D0.03544642
139CDK20.03522633
140LATS10.03061175
141CSF1R0.02634382
142PLK40.02311802
143PRKCD0.02242614
144INSR0.02120247
145PIM10.01598741
146CDK60.01207073
147PRKACG0.01047814
148RPS6KA30.00659796
149CDK10.00491404
150EGFR-0.0221460
151PRKACA-0.0167836
152AURKA-0.0120554
153CSNK2A2-0.0065120
154CAMK2B-0.0011659

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.78464753
2Fatty acid biosynthesis_Homo sapiens_hsa000614.79872081
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.32179764
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.18483165
5Linoleic acid metabolism_Homo sapiens_hsa005913.10275342
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.00136117
7Pyruvate metabolism_Homo sapiens_hsa006202.97673553
8Vitamin B6 metabolism_Homo sapiens_hsa007502.79417025
9Carbohydrate digestion and absorption_Homo sapiens_hsa049732.53255262
10Butanoate metabolism_Homo sapiens_hsa006502.47788214
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.40454118
12Glucagon signaling pathway_Homo sapiens_hsa049222.32803220
13Propanoate metabolism_Homo sapiens_hsa006402.07541803
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.98533864
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.95766707
16Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.88348724
17Basal transcription factors_Homo sapiens_hsa030221.85535654
18Glycerolipid metabolism_Homo sapiens_hsa005611.85091388
19Amphetamine addiction_Homo sapiens_hsa050311.83640030
20Glycerophospholipid metabolism_Homo sapiens_hsa005641.78883067
21Selenocompound metabolism_Homo sapiens_hsa004501.78699734
22PPAR signaling pathway_Homo sapiens_hsa033201.78189537
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.74274973
24Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.68576727
25Mineral absorption_Homo sapiens_hsa049781.67035584
26Fructose and mannose metabolism_Homo sapiens_hsa000511.59709558
27Fat digestion and absorption_Homo sapiens_hsa049751.52447276
28Oocyte meiosis_Homo sapiens_hsa041141.48245259
29Ether lipid metabolism_Homo sapiens_hsa005651.43895732
30Fatty acid degradation_Homo sapiens_hsa000711.36824245
31Fatty acid metabolism_Homo sapiens_hsa012121.33836501
32Type I diabetes mellitus_Homo sapiens_hsa049401.33486115
33Cardiac muscle contraction_Homo sapiens_hsa042601.30142869
34Dorso-ventral axis formation_Homo sapiens_hsa043201.25956204
35Phenylalanine metabolism_Homo sapiens_hsa003601.25076954
36Allograft rejection_Homo sapiens_hsa053301.24912203
37Phototransduction_Homo sapiens_hsa047441.23938701
38Autoimmune thyroid disease_Homo sapiens_hsa053201.22980638
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.16110932
40Graft-versus-host disease_Homo sapiens_hsa053321.15781018
41Carbon metabolism_Homo sapiens_hsa012001.15510744
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.14368202
43Insulin secretion_Homo sapiens_hsa049111.10239710
44Pentose phosphate pathway_Homo sapiens_hsa000301.08212393
45Arginine and proline metabolism_Homo sapiens_hsa003301.08037814
46Renin secretion_Homo sapiens_hsa049241.06649785
47Long-term potentiation_Homo sapiens_hsa047201.06572437
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06039122
49Bile secretion_Homo sapiens_hsa049761.00667912
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99739360
51Salivary secretion_Homo sapiens_hsa049700.98520111
52Purine metabolism_Homo sapiens_hsa002300.98052108
53Circadian entrainment_Homo sapiens_hsa047130.96005928
54Glutathione metabolism_Homo sapiens_hsa004800.95929432
55Antigen processing and presentation_Homo sapiens_hsa046120.95288664
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93090404
57Thyroid hormone synthesis_Homo sapiens_hsa049180.92677959
58Hedgehog signaling pathway_Homo sapiens_hsa043400.92109411
59Arginine biosynthesis_Homo sapiens_hsa002200.91766559
60Collecting duct acid secretion_Homo sapiens_hsa049660.91701335
61Fanconi anemia pathway_Homo sapiens_hsa034600.90823470
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.88014838
63Arachidonic acid metabolism_Homo sapiens_hsa005900.87924807
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.87725900
65Viral myocarditis_Homo sapiens_hsa054160.84652695
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84239346
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.83458674
68Estrogen signaling pathway_Homo sapiens_hsa049150.82476939
69mRNA surveillance pathway_Homo sapiens_hsa030150.79810107
70Chemical carcinogenesis_Homo sapiens_hsa052040.79796681
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78022973
72Synaptic vesicle cycle_Homo sapiens_hsa047210.75109739
73Pancreatic secretion_Homo sapiens_hsa049720.74742746
74Calcium signaling pathway_Homo sapiens_hsa040200.74249594
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.71817528
76Nicotine addiction_Homo sapiens_hsa050330.67767227
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67008984
78Renin-angiotensin system_Homo sapiens_hsa046140.66708248
79Gastric acid secretion_Homo sapiens_hsa049710.65316087
80Biosynthesis of amino acids_Homo sapiens_hsa012300.64782495
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64577116
82Influenza A_Homo sapiens_hsa051640.62758485
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.61950245
84Huntingtons disease_Homo sapiens_hsa050160.60685746
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60047907
86Systemic lupus erythematosus_Homo sapiens_hsa053220.59748327
87cAMP signaling pathway_Homo sapiens_hsa040240.58298456
88Nitrogen metabolism_Homo sapiens_hsa009100.57411531
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56892429
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56677647
91Taste transduction_Homo sapiens_hsa047420.56580633
92Tyrosine metabolism_Homo sapiens_hsa003500.56313578
93Inositol phosphate metabolism_Homo sapiens_hsa005620.54655821
94Glutamatergic synapse_Homo sapiens_hsa047240.53997671
95Cocaine addiction_Homo sapiens_hsa050300.53971453
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.53481224
97Acute myeloid leukemia_Homo sapiens_hsa052210.50606148
98Serotonergic synapse_Homo sapiens_hsa047260.50256354
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50072020
100Tight junction_Homo sapiens_hsa045300.49538834
101Protein digestion and absorption_Homo sapiens_hsa049740.49246098
102Retinol metabolism_Homo sapiens_hsa008300.48243071
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46721408
104MAPK signaling pathway_Homo sapiens_hsa040100.46299755
105Endocytosis_Homo sapiens_hsa041440.45645328
106Legionellosis_Homo sapiens_hsa051340.45552515
107RNA transport_Homo sapiens_hsa030130.45149008
108Cholinergic synapse_Homo sapiens_hsa047250.44834590
109ECM-receptor interaction_Homo sapiens_hsa045120.41009435
110ABC transporters_Homo sapiens_hsa020100.40092629
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38815044
112GABAergic synapse_Homo sapiens_hsa047270.38673482
113Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36035359
114Alcoholism_Homo sapiens_hsa050340.31802689
115AMPK signaling pathway_Homo sapiens_hsa041520.31758223
116Metabolic pathways_Homo sapiens_hsa011000.30927707
117Sulfur metabolism_Homo sapiens_hsa009200.30313739
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24978600
119Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24141345
120VEGF signaling pathway_Homo sapiens_hsa043700.24106189
121Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.23902845
122Prolactin signaling pathway_Homo sapiens_hsa049170.23773437
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.23706838
124Viral carcinogenesis_Homo sapiens_hsa052030.22453902
125Type II diabetes mellitus_Homo sapiens_hsa049300.22334441
126Vitamin digestion and absorption_Homo sapiens_hsa049770.20727711
127Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20483689
128Morphine addiction_Homo sapiens_hsa050320.19964596
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.18691717
130Dopaminergic synapse_Homo sapiens_hsa047280.17999798
131Oxytocin signaling pathway_Homo sapiens_hsa049210.17366766
132Platelet activation_Homo sapiens_hsa046110.17022563
133Olfactory transduction_Homo sapiens_hsa047400.16863750
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.16225486
135Steroid hormone biosynthesis_Homo sapiens_hsa001400.15006230
136Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.14677456
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.14194835
138Pyrimidine metabolism_Homo sapiens_hsa002400.13596948
139Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.13531961

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