BPIFB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene may be involved in the innate immune response to bacterial exposure in the mouth, nasal cavities, and lungs. The encoded protein is secreted and is a member of the BPI/LBP/PLUNC protein superfamily. This gene is found with other members of the superfamily in a cluster on chromosome 20. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)9.69375477
2surfactant homeostasis (GO:0043129)9.30434161
3left/right pattern formation (GO:0060972)8.89490936
4cell wall macromolecule catabolic process (GO:0016998)8.66014222
5cell wall macromolecule metabolic process (GO:0044036)8.66014222
6diterpenoid biosynthetic process (GO:0016102)7.62694849
7vitamin transmembrane transport (GO:0035461)7.56659907
8chemical homeostasis within a tissue (GO:0048875)7.55874624
9regulation of cilium movement (GO:0003352)7.05840790
10response to vitamin A (GO:0033189)6.92182712
11peptide cross-linking (GO:0018149)6.90594580
12left/right axis specification (GO:0070986)6.37180709
13microtubule bundle formation (GO:0001578)6.16754839
14ventricular system development (GO:0021591)6.14400003
15regulation of keratinocyte differentiation (GO:0045616)6.09322772
16pyrimidine-containing compound transmembrane transport (GO:0072531)6.07829196
17intraciliary transport (GO:0042073)5.91356428
18response to xenobiotic stimulus (GO:0009410)5.89629990
19tolerance induction (GO:0002507)5.71732943
20retinoic acid metabolic process (GO:0042573)5.69590485
21lymph vessel development (GO:0001945)5.67104880
22cilium organization (GO:0044782)5.52849002
23lung epithelium development (GO:0060428)5.50382187
24terpenoid biosynthetic process (GO:0016114)5.38708311
25cilium assembly (GO:0042384)5.38577740
26positive regulation of endothelial cell differentiation (GO:0045603)5.31209231
27sarcoplasmic reticulum calcium ion transport (GO:0070296)5.09297668
28negative regulation of T cell differentiation in thymus (GO:0033085)5.06811079
29ethanol oxidation (GO:0006069)4.96247030
30negative regulation of B cell mediated immunity (GO:0002713)4.93143556
31negative regulation of immunoglobulin mediated immune response (GO:0002890)4.93143556
32glomerular epithelial cell development (GO:0072310)4.92410328
33primary alcohol catabolic process (GO:0034310)4.87848085
34ethanol metabolic process (GO:0006067)4.85663797
35protein localization to cilium (GO:0061512)4.78463101
36centriole assembly (GO:0098534)4.77415146
37regulation of endothelial cell differentiation (GO:0045601)4.66798507
38cellular response to nitric oxide (GO:0071732)4.65965537
39negative regulation of humoral immune response (GO:0002921)4.65296885
40positive regulation of tolerance induction (GO:0002645)4.61057585
41coronary vasculature morphogenesis (GO:0060977)4.60621335
42regulation of relaxation of muscle (GO:1901077)4.58191562
43sperm capacitation (GO:0048240)4.54999562
44regulation of cardioblast proliferation (GO:0003264)4.45483195
45regulation of secondary heart field cardioblast proliferation (GO:0003266)4.45483195
46retinol metabolic process (GO:0042572)4.44910625
47regulation of vasculogenesis (GO:2001212)4.33927109
48microtubule-based movement (GO:0007018)4.32706827
49regulation of skeletal muscle contraction (GO:0014819)4.29234948
50cellular component assembly involved in morphogenesis (GO:0010927)4.26942329
51regulation of interleukin-5 production (GO:0032674)4.24859470
52multicellular organismal water homeostasis (GO:0050891)4.20357577
53skeletal muscle contraction (GO:0003009)4.17413430
54primary alcohol metabolic process (GO:0034308)4.15984928
55purine nucleotide salvage (GO:0032261)4.15655692
56regulation of microtubule-based movement (GO:0060632)4.08347270
57keratinocyte differentiation (GO:0030216)4.04581345
58morphogenesis of an endothelium (GO:0003159)4.03976847
59endothelial tube morphogenesis (GO:0061154)4.03976847
60bundle of His cell to Purkinje myocyte communication (GO:0086069)4.01257893
61cell projection assembly (GO:0030031)3.97484469
62blood vessel maturation (GO:0001955)3.95229278
63response to nitric oxide (GO:0071731)3.91431172
64cilium morphogenesis (GO:0060271)3.89886930
65lymphangiogenesis (GO:0001946)3.87137939
66cytoplasmic microtubule organization (GO:0031122)3.75133498
67muscle organ morphogenesis (GO:0048644)3.73886191
68progesterone metabolic process (GO:0042448)3.72880178
69lung vasculature development (GO:0060426)3.68533859
70lung lobe morphogenesis (GO:0060463)3.63739006
71muscle filament sliding (GO:0030049)3.62695237
72actin-myosin filament sliding (GO:0033275)3.62695237
73cellular response to retinoic acid (GO:0071300)3.61635063
74glutathione derivative metabolic process (GO:1901685)3.61605973
75glutathione derivative biosynthetic process (GO:1901687)3.61605973
76regulation of epidermal cell differentiation (GO:0045604)3.60809112
77nucleoside diphosphate phosphorylation (GO:0006165)3.60405555
78cellular response to reactive nitrogen species (GO:1902170)3.60192528
79lipoxygenase pathway (GO:0019372)3.58137946
80hydrogen peroxide biosynthetic process (GO:0050665)3.58070179
81positive regulation of vasculogenesis (GO:2001214)3.51271888
82establishment of planar polarity (GO:0001736)3.50057690
83establishment of tissue polarity (GO:0007164)3.50057690
84water homeostasis (GO:0030104)3.47987219
85regulation of germinal center formation (GO:0002634)3.47544743
86regulation of tolerance induction (GO:0002643)3.47347255
87microtubule depolymerization (GO:0007019)3.46454374
88regulation of interleukin-13 production (GO:0032656)3.45098316
89negative regulation of inclusion body assembly (GO:0090084)3.42364236
90cellular response to epidermal growth factor stimulus (GO:0071364)3.38893367
91microtubule polymerization or depolymerization (GO:0031109)3.27847034
92positive regulation of smoothened signaling pathway (GO:0045880)3.21247208
93reactive oxygen species biosynthetic process (GO:1903409)3.18852544
94toxin metabolic process (GO:0009404)3.17615097
95respiratory tube development (GO:0030323)3.14871854
96regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.14658472
97establishment of apical/basal cell polarity (GO:0035089)3.13821427
98actin-mediated cell contraction (GO:0070252)3.10894813
99regulation of skeletal muscle cell differentiation (GO:2001014)3.09035017
100histamine secretion (GO:0001821)3.07432320
101linoleic acid metabolic process (GO:0043651)3.06757945
102regulation of integrin-mediated signaling pathway (GO:2001044)3.04898454
103extracellular negative regulation of signal transduction (GO:1900116)3.04453595
104extracellular regulation of signal transduction (GO:1900115)3.04453595
105cellular response to glucocorticoid stimulus (GO:0071385)3.04020996
106polyketide metabolic process (GO:0030638)3.03761051
107doxorubicin metabolic process (GO:0044598)3.03761051
108daunorubicin metabolic process (GO:0044597)3.03761051
109lateral sprouting from an epithelium (GO:0060601)3.02326790
110blood vessel remodeling (GO:0001974)3.01970607
111axonemal dynein complex assembly (GO:0070286)20.9517581
112outer ear morphogenesis (GO:0042473)2.98868647
113outflow tract septum morphogenesis (GO:0003148)2.98482049
114long-chain fatty acid biosynthetic process (GO:0042759)2.97336535
115apical protein localization (GO:0045176)2.96734694
116oligosaccharide biosynthetic process (GO:0009312)2.96582687
117regulation of microtubule depolymerization (GO:0031114)2.94586875
118phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.92451480
119embryonic viscerocranium morphogenesis (GO:0048703)2.91512451
120positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.91455226
121cellular response to corticosteroid stimulus (GO:0071384)2.91327455
122gas transport (GO:0015669)2.89738572
123ear development (GO:0043583)2.86910079
124aldehyde catabolic process (GO:0046185)2.86353913
125lung alveolus development (GO:0048286)2.85335962
126excretion (GO:0007588)2.85326385
127skeletal muscle adaptation (GO:0043501)2.85035782
128endothelial cell chemotaxis (GO:0035767)2.82194587
129response to epidermal growth factor (GO:0070849)2.79580249
130hydrogen peroxide catabolic process (GO:0042744)2.79166356
131peptide catabolic process (GO:0043171)2.79115613
132renal absorption (GO:0070293)2.78556656
133calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.78376963
134establishment or maintenance of monopolar cell polarity (GO:0061339)2.77925023
135establishment of monopolar cell polarity (GO:0061162)2.77925023
136hormone catabolic process (GO:0042447)2.77708095
137O-glycan processing (GO:0016266)2.76494299
138tooth mineralization (GO:0034505)2.76273187
139adhesion of symbiont to host cell (GO:0044650)2.76184108
140virion attachment to host cell (GO:0019062)2.76184108
141negative regulation of thymocyte apoptotic process (GO:0070244)2.74976673
142regulation of endothelial cell chemotaxis (GO:2001026)2.74885920
143dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.73735989
144epidermal cell differentiation (GO:0009913)2.73452424
145retinal metabolic process (GO:0042574)2.73186067
146sodium ion homeostasis (GO:0055078)2.72507600
147protein O-linked glycosylation (GO:0006493)2.71410183
148hypotonic response (GO:0006971)2.69150070
149aminoglycoside antibiotic metabolic process (GO:0030647)2.68622894
150lateral ventricle development (GO:0021670)2.67749321
151exogenous drug catabolic process (GO:0042738)2.67470499
152one-carbon compound transport (GO:0019755)2.65616947
153carnitine metabolic process (GO:0009437)2.65309923
154polyol transport (GO:0015791)2.65305791
155artery development (GO:0060840)2.65051388
156phosphatidylcholine biosynthetic process (GO:0006656)2.64139305
157muscle cell fate commitment (GO:0042693)2.63297612
158actin filament-based movement (GO:0030048)2.62454842
159hemidesmosome assembly (GO:0031581)2.62043870
160extracellular fibril organization (GO:0043206)2.60874888
161regulation of autophagic vacuole assembly (GO:2000785)2.60659050
162vascular endothelial growth factor signaling pathway (GO:0038084)2.60611131
163mesodermal cell differentiation (GO:0048333)2.59908159
164regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.59531614
165endothelial cell differentiation (GO:0045446)2.59164986
166cellular aldehyde metabolic process (GO:0006081)2.58578859
167positive regulation of myotube differentiation (GO:0010831)2.58246763
168glutathione metabolic process (GO:0006749)2.57973616
169aorta morphogenesis (GO:0035909)2.55233219
170negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.54768690
171negative regulation of calcium ion transmembrane transport (GO:1903170)2.54768690
172regulation of response to osmotic stress (GO:0047484)2.54356004
173microtubule-based process (GO:0007017)2.53348068
174respiratory gaseous exchange (GO:0007585)2.51238439
175positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.51122346
176response to retinoic acid (GO:0032526)2.47068334
177desmosome organization (GO:0002934)2.45601898
178regulation of penile erection (GO:0060405)2.43183507
179cilium or flagellum-dependent cell motility (GO:0001539)16.9205547
180cilium movement (GO:0003341)14.7340012
181motile cilium assembly (GO:0044458)14.2362224
182keratinization (GO:0031424)13.2115352
183epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)13.0072867
184epithelial cilium movement (GO:0003351)12.7844849

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human6.50796452
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.58442822
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.72643733
4ZNF652_21678463_ChIP-ChIP_ZR75-1_Human4.12627109
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.67419949
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.29889355
7ESR1_21235772_ChIP-Seq_MCF-7_Human3.29045405
8RARG_19884340_ChIP-ChIP_MEFs_Mouse3.27610952
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.72862653
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.47922081
11CLOCK_20551151_ChIP-Seq_293T_Human2.38743266
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.37447711
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.34356694
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.95115933
15SOX2_20726797_ChIP-Seq_SW620_Human1.90785768
16CDX2_19796622_ChIP-Seq_MESCs_Mouse1.88835343
17CJUN_26792858_Chip-Seq_BT549_Human1.79339505
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.79097199
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.78244187
20GATA2_21666600_ChIP-Seq_HMVEC_Human1.77438214
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.66656371
22KLF5_25053715_ChIP-Seq_YYC3_Human1.66131382
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.62195897
24BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.60150550
25TP63_22573176_ChIP-Seq_HFKS_Human1.55069604
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.53397906
27TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53128393
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52519355
29CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.52047934
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.49125424
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.47338115
32RAD21_21589869_ChIP-Seq_MESCs_Mouse1.47003272
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45749520
34FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45292402
35FOXA1_25552417_ChIP-Seq_VCAP_Human1.44009888
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.42019309
37TDRD3_21172665_ChIP-Seq_MCF-7_Human1.40228390
38ELF1_20517297_ChIP-Seq_JURKAT_Human1.39631144
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39613193
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.39601391
41SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.38588796
42AHR_22903824_ChIP-Seq_MCF-7_Human1.37246856
43FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.36447549
44SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.35340115
45SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.35340115
46CTNNB1_20460455_ChIP-Seq_HCT116_Human1.33466153
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.32927254
48P63_26484246_Chip-Seq_KERATINOCYTES_Human1.31491879
49TBX20_22080862_ChIP-Seq_HEART_Mouse1.31303156
50TBX20_22328084_ChIP-Seq_HEART_Mouse1.31303156
51CDX2_20551321_ChIP-Seq_CACO-2_Human1.26998178
52CTCF_27219007_Chip-Seq_Bcells_Human1.23015170
53RACK7_27058665_Chip-Seq_MCF-7_Human1.22836705
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21563183
55ETV1_20927104_ChIP-Seq_GIST48_Human1.20884380
56EP300_21415370_ChIP-Seq_HL-1_Mouse1.20156508
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19352656
58FOXA2_19822575_ChIP-Seq_HepG2_Human1.19352073
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19066606
60CREB1_26743006_Chip-Seq_LNCaP_Human1.18366310
61SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18267635
62P68_20966046_ChIP-Seq_HELA_Human1.18215853
63SMRT_27268052_Chip-Seq_Bcells_Human1.17074477
64AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.16431350
65GATA3_24758297_ChIP-Seq_MCF-7_Human1.15550127
66VDR_22108803_ChIP-Seq_LS180_Human1.15388375
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14866547
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13856395
69PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.11718448
70SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11186343
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.10988223
72PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10920245
73SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10067536
74RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09604071
75HNFA_21074721_ChIP-Seq_CACO-2_Human1.08937639
76CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.08856560
77CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08682427
78YY1_22570637_ChIP-Seq_MALME-3M_Human1.08598633
79ERG_20517297_ChIP-Seq_VCAP_Human1.07198933
80CTCF_20526341_ChIP-Seq_ESCs_Human1.06995143
81SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06752259
82FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.06107993
83TP53_18474530_ChIP-ChIP_U2OS_Human1.05726098
84CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05459534
85PHF8_20622853_ChIP-Seq_HELA_Human1.05046843
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04696875
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04175714
88NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04175714
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01584726
90PHF8_20622854_ChIP-Seq_HELA_Human1.01389204
91ARNT_22903824_ChIP-Seq_MCF-7_Human0.99568389
92RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99382419
93FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99320001
94ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.99188723
95LXR_22292898_ChIP-Seq_THP-1_Human0.98390908
96CEBPB_22108803_ChIP-Seq_LS180_Human0.98386091
97RBPJ_21746931_ChIP-Seq_IB4_Human0.98194843
98GATA2_19941826_ChIP-Seq_K562_Human0.97782337
99SMC4_20622854_ChIP-Seq_HELA_Human0.96941341
100KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96636847
101SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96414429
102GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.95758744
103TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95352979
104CSB_26484114_Chip-Seq_FIBROBLAST_Human0.95199119
105JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95141274
106SMAD3_21741376_ChIP-Seq_HESCs_Human0.94399391
107RXR_22108803_ChIP-Seq_LS180_Human0.94257248
108SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93224236
109CBX2_22325352_ChIP-Seq_293T-Rex_Human0.93168786
110ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93111083
111PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91776035
112TCF4_18268006_ChIP-ChIP_LS174T_Human0.91631023
113ZNF263_19887448_ChIP-Seq_K562_Human0.90609938
114OCT1_27270436_Chip-Seq_PROSTATE_Human0.90581975
115RUNX1_27514584_Chip-Seq_MCF-7_Human0.90415964
116EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90099471
117ELK3_25401928_ChIP-Seq_HUVEC_Human0.89973999
118GATA4_25053715_ChIP-Seq_YYC3_Human0.89567744
119SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89068399
120FLI1_21867929_ChIP-Seq_CD8_Mouse0.88583375
121FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87707955
122CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.87390507
123TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87286820
124STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87089633
125P300_27268052_Chip-Seq_Bcells_Human0.86828552
126FOXH1_21741376_ChIP-Seq_ESCs_Human0.86387206
127TP63_23658742_ChIP-Seq_EP156T_Human0.86053670
128JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85723813
129BCAT_22108803_ChIP-Seq_LS180_Human0.85543793
130P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.85496370
131NFYA_21822215_ChIP-Seq_K562_Human0.85377024
132GATA6_21074721_ChIP-Seq_CACO-2_Human0.84774630
133LXR_22158963_ChIP-Seq_LIVER_Mouse0.84156812
134CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83742072
135IKZF1_21737484_ChIP-ChIP_HCT116_Human0.83627398
136ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83475691
137E2F1_20622854_ChIP-Seq_HELA_Human0.83429627
138HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83257790
139STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.82940086
140SOX2_21211035_ChIP-Seq_LN229_Human0.82535052
141TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81745516
142STAT1_20625510_ChIP-Seq_HELA_Human0.80842594
143GATA1_19941826_ChIP-Seq_K562_Human0.80798377
144PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80437924
145RXR_22158963_ChIP-Seq_LIVER_Mouse0.80246685
146Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80191077
147PCGF2_27294783_Chip-Seq_NPCs_Mouse0.79765903
148EGR1_19032775_ChIP-ChIP_M12_Human0.79117064
149PPARA_22158963_ChIP-Seq_LIVER_Mouse0.76018190
150PCGF2_27294783_Chip-Seq_ESCs_Mouse0.75828139
151DROSHA_22980978_ChIP-Seq_HELA_Human0.74761663

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology5.83459161
2MP0004782_abnormal_surfactant_physiolog5.71408043
3MP0001958_emphysema4.60891112
4MP0001879_abnormal_lymphatic_vessel3.90250396
5MP0001984_abnormal_olfaction3.74041497
6MP0010368_abnormal_lymphatic_system3.67956947
7MP0005275_abnormal_skin_tensile3.51846927
8MP0004133_heterotaxia3.29478458
9MP0008789_abnormal_olfactory_epithelium3.24191839
10MP0002234_abnormal_pharynx_morphology3.20594280
11MP0005623_abnormal_meninges_morphology3.12495903
12MP0002796_impaired_skin_barrier3.11737683
13MP0002132_abnormal_respiratory_system3.08164428
14MP0008875_abnormal_xenobiotic_pharmacok2.88701122
15MP0002138_abnormal_hepatobiliary_system2.85440666
16MP0004019_abnormal_vitamin_homeostasis2.76996823
17MP0008995_early_reproductive_senescence2.51481304
18MP0002277_abnormal_respiratory_mucosa2.47621537
19MP0000566_synostosis2.47419162
20MP0000751_myopathy2.32959530
21MP0000383_abnormal_hair_follicle2.27227702
22MP0000467_abnormal_esophagus_morphology2.23166213
23MP0003724_increased_susceptibility_to2.19692760
24MP0000762_abnormal_tongue_morphology2.17966734
25MP0000749_muscle_degeneration2.16534315
26MP0005394_taste/olfaction_phenotype2.14251107
27MP0005499_abnormal_olfactory_system2.14251107
28MP0010678_abnormal_skin_adnexa2.13060368
29MP0005167_abnormal_blood-brain_barrier2.06773957
30MP0003646_muscle_fatigue2.05214086
31MP0003656_abnormal_erythrocyte_physiolo2.04640842
32MP0003191_abnormal_cellular_cholesterol2.02734902
33MP0008004_abnormal_stomach_pH1.98945314
34MP0003950_abnormal_plasma_membrane1.89593192
35MP0002133_abnormal_respiratory_system1.88962295
36MP0005388_respiratory_system_phenotype1.88962295
37MP0005377_hearing/vestibular/ear_phenot1.88193262
38MP0003878_abnormal_ear_physiology1.88193262
39MP0002837_dystrophic_cardiac_calcinosis1.76228548
40MP0001765_abnormal_ion_homeostasis1.75455338
41MP0000343_altered_response_to1.70154585
42MP0001177_atelectasis1.69143200
43MP0005083_abnormal_biliary_tract1.65560244
44MP0004272_abnormal_basement_membrane1.58814715
45MP0010155_abnormal_intestine_physiology1.58525943
46MP0003566_abnormal_cell_adhesion1.57238331
47MP0002160_abnormal_reproductive_system1.57232109
48MP0010234_abnormal_vibrissa_follicle1.54799822
49MP0005501_abnormal_skin_physiology1.50994636
50MP0002295_abnormal_pulmonary_circulatio1.42673662
51MP0002095_abnormal_skin_pigmentation1.36796209
52MP0009697_abnormal_copulation1.36074249
53MP0005395_other_phenotype1.35222465
54MP0000465_gastrointestinal_hemorrhage1.33902943
55MP0000678_abnormal_parathyroid_gland1.32103186
56MP0003303_peritoneal_inflammation1.29627989
57MP0006054_spinal_hemorrhage1.29356113
58MP0004036_abnormal_muscle_relaxation1.29352811
59MP0002106_abnormal_muscle_physiology1.28900678
60MP0001243_abnormal_dermal_layer1.25077100
61MP0005165_increased_susceptibility_to1.22849451
62MP0000371_diluted_coat_color1.21494634
63MP0002332_abnormal_exercise_endurance1.20546368
64MP0008438_abnormal_cutaneous_collagen1.20040870
65MP0004264_abnormal_extraembryonic_tissu1.19065529
66MP0005636_abnormal_mineral_homeostasis1.18062029
67MP0003252_abnormal_bile_duct1.16617452
68MP0004130_abnormal_muscle_cell1.14092458
69MP0004084_abnormal_cardiac_muscle1.13762671
70MP0003705_abnormal_hypodermis_morpholog1.13672183
71MP0009379_abnormal_foot_pigmentation1.13094748
72MP0000470_abnormal_stomach_morphology1.10883116
73MP0002139_abnormal_hepatobiliary_system1.10669256
74MP0004087_abnormal_muscle_fiber1.10623219
75MP0000759_abnormal_skeletal_muscle1.10023146
76MP0000249_abnormal_blood_vessel1.08315067
77MP0006138_congestive_heart_failure1.07301344
78MP0005058_abnormal_lysosome_morphology1.06414387
79MP0000858_altered_metastatic_potential1.03775120
80MP0004185_abnormal_adipocyte_glucose1.03323688
81MP0001175_abnormal_lung_morphology1.03106167
82MP0002876_abnormal_thyroid_physiology1.02980179
83MP0000681_abnormal_thyroid_gland1.01709030
84MP0004484_altered_response_of1.01300315
85MP0001544_abnormal_cardiovascular_syste1.00605653
86MP0005385_cardiovascular_system_phenoty1.00605653
87MP0003075_altered_response_to0.97886981
88MP0002233_abnormal_nose_morphology0.97276083
89MP0005369_muscle_phenotype0.96261938
90MP0001849_ear_inflammation0.94055684
91MP0004883_abnormal_blood_vessel0.92867588
92MP0005164_abnormal_response_to0.92366252
93MP0003279_aneurysm0.92098900
94MP0002972_abnormal_cardiac_muscle0.91380187
95MP0000750_abnormal_muscle_regeneration0.90142230
96MP0002909_abnormal_adrenal_gland0.89934432
97MP0005595_abnormal_vascular_smooth0.89584746
98MP0005620_abnormal_muscle_contractility0.88183261
99MP0000767_abnormal_smooth_muscle0.87338314
100MP0000747_muscle_weakness0.86011142
101MP0000733_abnormal_muscle_development0.85743231
102MP0003828_pulmonary_edema0.85691127
103MP0002734_abnormal_mechanical_nocicepti0.84450332
104MP0002127_abnormal_cardiovascular_syste0.84254045
105MP0002282_abnormal_trachea_morphology0.83832840
106MP0009643_abnormal_urine_homeostasis0.82901281
107MP0004043_abnormal_pH_regulation0.81526529
108MP0005365_abnormal_bile_salt0.81376311
109MP0001542_abnormal_bone_strength0.80784497
110MP0005248_abnormal_Harderian_gland0.79571161
111MP0004145_abnormal_muscle_electrophysio0.78971426
112MP0001851_eye_inflammation0.78306981
113MP0009765_abnormal_xenobiotic_induced0.76546724
114MP0002249_abnormal_larynx_morphology0.74205096
115MP0002136_abnormal_kidney_physiology0.73936915
116MP0009763_increased_sensitivity_to0.73843378
117MP0001485_abnormal_pinna_reflex0.73736913
118MP0010030_abnormal_orbit_morphology0.72697970
119MP0005330_cardiomyopathy0.72357853
120MP0005310_abnormal_salivary_gland0.71590280
121MP0003453_abnormal_keratinocyte_physiol0.71188148
122MP0003091_abnormal_cell_migration0.69504937
123MP0005085_abnormal_gallbladder_physiolo0.69478441
124MP0005503_abnormal_tendon_morphology0.69429893
125MP0002168_other_aberrant_phenotype0.69400872
126MP0005220_abnormal_exocrine_pancreas0.69246758
127MP0010771_integument_phenotype0.67397085
128MP0005166_decreased_susceptibility_to0.67189253
129MP0003866_abnormal_defecation0.67025393
130MP0005389_reproductive_system_phenotype0.67003458
131MP0005023_abnormal_wound_healing0.65097975
132MP0001216_abnormal_epidermal_layer0.64903355
133MP0001346_abnormal_lacrimal_gland0.64013879
134MP0002405_respiratory_system_inflammati0.63641263
135MP0002735_abnormal_chemical_nociception0.62933275
136MP0002896_abnormal_bone_mineralization0.62127370
137MP0005409_darkened_coat_color0.61641285
138MP0002128_abnormal_blood_circulation0.61005741
139MP0001943_abnormal_respiration0.60969931
140MP0002098_abnormal_vibrissa_morphology0.60374146
141MP0003806_abnormal_nucleotide_metabolis0.60326011
142MP0002638_abnormal_pupillary_reflex0.59998054
143MP0004947_skin_inflammation0.59879631
144MP0009780_abnormal_chondrocyte_physiolo0.59719535
145MP0001664_abnormal_digestion0.58309003
146MP0005408_hypopigmentation0.57678469
147MP0001929_abnormal_gametogenesis0.57532686
148MP0001270_distended_abdomen0.57032267
149MP0001663_abnormal_digestive_system0.56658991
150MP0006082_CNS_inflammation0.55145291
151MP0003698_abnormal_male_reproductive0.50557883
152MP0003890_abnormal_embryonic-extraembry0.49078628
153MP0009703_decreased_birth_body0.47155709
154MP0005387_immune_system_phenotype0.47071749
155MP0001790_abnormal_immune_system0.47071749
156MP0002116_abnormal_craniofacial_bone0.43134248
157MP0000026_abnormal_inner_ear0.40976110
158MP0008873_increased_physiological_sensi0.40950918
159MP0008872_abnormal_physiological_respon0.40808504
160MP0001666_abnormal_nutrient_absorption0.40125325
161MP0001944_abnormal_pancreas_morphology0.40067378
162MP0001293_anophthalmia0.39244459
163MP0001324_abnormal_eye_pigmentation0.39043344
164MP0000477_abnormal_intestine_morphology0.37565340

Predicted human phenotypes

RankGene SetZ-score
1Oral leukoplakia (HP:0002745)9.16847693
2Interstitial pulmonary disease (HP:0006530)6.11539741
3Hyperactive renin-angiotensin system (HP:0000841)6.02321436
4Chronic bronchitis (HP:0004469)5.73068059
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.66096690
6Distal arthrogryposis (HP:0005684)4.63272483
7Muscle fiber inclusion bodies (HP:0100299)4.62922701
8Recurrent sinusitis (HP:0011108)4.50095676
9Round ear (HP:0100830)4.47476717
10Exercise-induced myalgia (HP:0003738)4.39173570
11Nemaline bodies (HP:0003798)4.36439365
12Infertility (HP:0000789)4.21690076
13Hyperkalemia (HP:0002153)4.11195495
14Autoimmune thrombocytopenia (HP:0001973)4.07020176
15Abnormality of the nasal mucosa (HP:0000433)4.06312455
16Male infertility (HP:0003251)4.05745593
17Recurrent otitis media (HP:0000403)3.90704964
18Renal salt wasting (HP:0000127)3.83241912
19Type 1 muscle fiber predominance (HP:0003803)3.80445905
20Exercise-induced muscle cramps (HP:0003710)3.74510407
21Polycythemia (HP:0001901)3.71608313
22Right ventricular cardiomyopathy (HP:0011663)3.65838131
23Ulnar deviation of the wrist (HP:0003049)3.56331288
24Increased connective tissue (HP:0009025)3.54879720
25Occipital encephalocele (HP:0002085)3.48734169
26Cupped ribs (HP:0000887)3.35625239
27Tubulointerstitial fibrosis (HP:0005576)3.33727629
28Pancreatic fibrosis (HP:0100732)3.25782562
29Double outlet right ventricle (HP:0001719)3.23120603
30Congenital malformation of the right heart (HP:0011723)3.23120603
31True hermaphroditism (HP:0010459)3.21268213
32Absent phalangeal crease (HP:0006109)3.15924599
33Autoimmune hemolytic anemia (HP:0001890)3.10383627
34Chronic otitis media (HP:0000389)3.10197065
35Tetany (HP:0001281)3.09320585
36Atelectasis (HP:0100750)3.07652225
37Increased IgE level (HP:0003212)3.02212429
38Muscle hypertrophy of the lower extremities (HP:0008968)2.99796640
39Hypoplastic left heart (HP:0004383)2.97919535
40Hyperaldosteronism (HP:0000859)2.97488478
41Myopathic facies (HP:0002058)2.97086560
42Onycholysis (HP:0001806)2.96537428
43Difficulty running (HP:0009046)2.94907502
44Calf muscle hypertrophy (HP:0008981)2.92886917
45Hematochezia (HP:0002573)2.92138876
46Abnormality of skeletal muscle fiber size (HP:0012084)2.90544925
47Distal lower limb muscle weakness (HP:0009053)2.87362280
48Myoglobinuria (HP:0002913)2.87031540
49Increased variability in muscle fiber diameter (HP:0003557)2.86672161
50Gout (HP:0001997)2.82679656
51Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.82444242
52Long clavicles (HP:0000890)2.81095728
53Muscle fiber splitting (HP:0003555)2.79676061
54Bronchitis (HP:0012387)2.78326218
55Cystic liver disease (HP:0006706)2.75086353
56Mesangial abnormality (HP:0001966)2.71930996
57Facial diplegia (HP:0001349)2.70941968
58Unilateral renal agenesis (HP:0000122)2.69017493
59Rimmed vacuoles (HP:0003805)2.68580584
60Calcaneovalgus deformity (HP:0001848)2.68246367
61Hyporeflexia of lower limbs (HP:0002600)2.65686307
62Spontaneous hematomas (HP:0007420)2.64807640
63Respiratory distress (HP:0002098)2.61178138
64Tachypnea (HP:0002789)2.60920187
65Molar tooth sign on MRI (HP:0002419)2.60576478
66Abnormality of midbrain morphology (HP:0002418)2.60576478
67Pancreatic cysts (HP:0001737)2.58225994
68Abnormal finger flexion creases (HP:0006143)2.58213581
69Hypokalemic alkalosis (HP:0001949)2.54292896
70Decreased circulating renin level (HP:0003351)2.53068348
71EMG: myopathic abnormalities (HP:0003458)2.51540024
72Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.51276049
73Hypoplastic ischia (HP:0003175)2.50077389
74Nephronophthisis (HP:0000090)2.49784582
75Abnormality of renin-angiotensin system (HP:0000847)2.39779538
76Muscle stiffness (HP:0003552)2.38419283
77Frequent falls (HP:0002359)2.33986177
78Postaxial foot polydactyly (HP:0001830)2.32334954
79Deformed tarsal bones (HP:0008119)2.31231147
80Chronic hepatic failure (HP:0100626)2.27467085
81Nasal polyposis (HP:0100582)2.26929811
82Congenital ichthyosiform erythroderma (HP:0007431)2.26670491
83Hypoplastic heart (HP:0001961)2.26089797
84Myotonia (HP:0002486)2.22084273
85Hypotension (HP:0002615)2.21962837
86Abnormality of the ischium (HP:0003174)2.19406949
87B lymphocytopenia (HP:0010976)2.17280850
88Abnormality of B cell number (HP:0010975)2.17280850
89Neck muscle weakness (HP:0000467)2.14821549
90Pulmonary artery stenosis (HP:0004415)2.13855447
91Abnormal respiratory motile cilium physiology (HP:0012261)2.12516841
92Cerebral hemorrhage (HP:0001342)2.11017425
93Abnormality of the parathyroid morphology (HP:0011766)2.09919667
94Tubulointerstitial nephritis (HP:0001970)2.08660846
95Esophageal varix (HP:0002040)2.08079965
96Spinal rigidity (HP:0003306)2.07552937
97Rhinitis (HP:0012384)2.06854038
98Bronchiectasis (HP:0002110)2.06744703
99Abnormality of the aortic arch (HP:0012303)2.06319105
100Abnormal respiratory epithelium morphology (HP:0012253)11.2323479
101Abnormal respiratory motile cilium morphology (HP:0005938)11.2323479
102Dynein arm defect of respiratory motile cilia (HP:0012255)10.7651406
103Absent/shortened dynein arms (HP:0200106)10.7651406
104Abnormal ciliary motility (HP:0012262)1.99317453
105Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.98447191
106Abnormality of the calf musculature (HP:0001430)1.97495736
107Distal lower limb amyotrophy (HP:0008944)1.97067070
108Abnormality of chloride homeostasis (HP:0011422)1.96302832
109Abnormality of the renal medulla (HP:0100957)1.95677709
110Wrist flexion contracture (HP:0001239)1.93523051
111Absent frontal sinuses (HP:0002688)1.91816408
112Congenital hepatic fibrosis (HP:0002612)1.90353133
113Seborrheic dermatitis (HP:0001051)1.89449701
114Bell-shaped thorax (HP:0001591)1.88303863
115Tubulointerstitial abnormality (HP:0001969)1.87180651
116Anencephaly (HP:0002323)1.85998946
117Paralysis (HP:0003470)1.85557904
118Aplasia/Hypoplasia of the tongue (HP:0010295)1.83885287
119Recurrent bronchitis (HP:0002837)1.83386009
120Male pseudohermaphroditism (HP:0000037)1.83051593
121Abnormality of the calcaneus (HP:0008364)1.82468030
122Corneal erosion (HP:0200020)1.82377909
123Woolly hair (HP:0002224)1.81964882
124Cholelithiasis (HP:0001081)1.81673948
125Aplasia/Hypoplasia of the spleen (HP:0010451)1.75971968
126Visceral angiomatosis (HP:0100761)1.75493285
127Annular pancreas (HP:0001734)1.74989563
128Chronic sinusitis (HP:0011109)1.74944079
129Mildly elevated creatine phosphokinase (HP:0008180)1.74939196
130Asplenia (HP:0001746)1.67371823
131Nephropathy (HP:0000112)1.66376898
132Medial flaring of the eyebrow (HP:0010747)1.65512244
133Furrowed tongue (HP:0000221)1.58370745
134Congenital primary aphakia (HP:0007707)1.57339799
135Oculomotor apraxia (HP:0000657)1.55833846
136Gait imbalance (HP:0002141)1.53845321
137Tubular atrophy (HP:0000092)1.52090553
138Sclerocornea (HP:0000647)1.51963833
139Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.48531880
140Postaxial hand polydactyly (HP:0001162)1.43754427
141Hyponatremia (HP:0002902)1.41389878
142Abnormality of the distal phalanges of the toes (HP:0010182)1.38383667
143Abnormality of monocarboxylic acid metabolism (HP:0010996)1.37570325
144Nephrogenic diabetes insipidus (HP:0009806)1.35462459
145Hand muscle atrophy (HP:0009130)1.34884688
146Glucose intolerance (HP:0000833)1.34168975
147Bifid scrotum (HP:0000048)1.31285266
148Short thorax (HP:0010306)1.24192522
149Median cleft lip (HP:0000161)1.22180327
150Abnormality of the dental root (HP:0006486)1.20399800
151Taurodontia (HP:0000679)1.20399800
152Abnormality of permanent molar morphology (HP:0011071)1.20399800
153Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.18637024
154Obstructive sleep apnea (HP:0002870)1.18419855
155Abnormality of the frontal sinuses (HP:0002687)1.17408040
156Preaxial hand polydactyly (HP:0001177)1.15577701
157Fetal akinesia sequence (HP:0001989)1.14208835
158Short nail (HP:0001799)1.12217709
159Short femoral neck (HP:0100864)1.12134342
160Flat acetabular roof (HP:0003180)1.12078653
161Abnormality of molar (HP:0011077)1.10604527
162Abnormality of molar morphology (HP:0011070)1.10604527
163Absent rod-and cone-mediated responses on ERG (HP:0007688)1.10306873
164Cone-rod dystrophy (HP:0000548)1.10076858
165Abnormality of sodium homeostasis (HP:0010931)1.09067532
166Stage 5 chronic kidney disease (HP:0003774)1.08307692
167Popliteal pterygium (HP:0009756)1.08084920
168Lip pit (HP:0100267)1.07297464
169Abnormality of the dental pulp (HP:0006479)1.05894324
170Vascular calcification (HP:0004934)1.05844194
171Poor coordination (HP:0002370)1.05063439
172Limb-girdle muscle atrophy (HP:0003797)1.04835642
173Spinal cord compression (HP:0002176)1.04667556
174Spinal muscular atrophy (HP:0007269)1.03737461
175Aplasia of the musculature (HP:0100854)1.03601646
176Decreased central vision (HP:0007663)1.03336887
177Vaginal atresia (HP:0000148)1.02182443
178Genital tract atresia (HP:0001827)1.01385520
179Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.01149215

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN6.96791245
2TIE15.47440871
3TGFBR23.34304138
4PIK3CG2.95709649
5SMG12.89475899
6MST42.77683314
7EPHB22.50058065
8OBSCN2.41686098
9LRRK22.13968835
10PHKG22.06915447
11PHKG12.06915447
12TTK2.05236571
13MYLK2.02697250
14MAP2K32.01178956
15MAPK1510.9639812
16TRIB31.94412080
17EEF2K1.94374146
18STK241.83131473
19MAP3K31.82644888
20FER1.75598310
21PDK21.74763044
22ERBB31.73251930
23GRK11.68278163
24STK101.65365219
25MAP3K121.52563781
26PAK41.31441508
27ERN11.30628542
28NEK61.29913854
29RIPK41.25646536
30PBK1.19473534
31TRPM71.19361326
32EPHB11.18527692
33PINK11.18041818
34DMPK1.18001749
35PDK31.15316103
36PDK41.15316103
37ZAP701.11132132
38TESK11.09513884
39CSK1.09036584
40RIPK11.08494880
41FGFR41.08170454
42MARK21.07374878
43ILK1.06802908
44FGFR31.05753725
45DAPK21.04579246
46ICK1.03632022
47LIMK11.03251108
48STK380.99371302
49NME10.96902493
50PNCK0.95742441
51DDR20.95431663
52TGFBR10.91832756
53EPHA20.90968247
54PKN20.87227680
55PTK60.86864282
56CAMKK10.83473700
57PRKCI0.82877456
58TLK10.80610144
59SGK30.78725210
60PRKD10.78154738
61PDGFRB0.78038610
62MAPK120.74488625
63MAP3K20.71738306
64NEK90.71590888
65SGK20.70682605
66TEC0.70656885
67PTK2B0.69268880
68EPHA30.67334406
69PRKCH0.67303008
70FGFR20.67167974
71MAP2K60.66938360
72ERBB20.64160897
73STK38L0.62010743
74SGK4940.60602031
75SGK2230.60602031
76PRKD30.60411853
77BRSK20.59308761
78NEK10.56102762
79JAK10.53613755
80KDR0.51994757
81PDPK10.51977405
82MST1R0.51570630
83PRKAA20.51350906
84GRK60.50961274
85PRKG20.50781212
86EGFR0.50527178
87ROCK20.50274371
88HIPK20.49246576
89TYK20.48492079
90PIK3CA0.44531279
91BCR0.44342082
92AKT30.43295587
93MAP2K10.42289750
94NLK0.42155559
95CDC42BPA0.42070226
96TAOK10.41495768
97IRAK10.41462131
98AURKA0.41424536
99DYRK1B0.41226742
100PDGFRA0.41150383
101MET0.41012971
102MAP3K70.39687741
103ROCK10.38155646
104PRKCD0.37620516
105MATK0.37596702
106SGK10.37536609
107LATS10.36572117
108MAPKAPK30.36509486
109BLK0.36182413
110MAP3K140.36151571
111STK160.36058327
112RPS6KB20.35756277
113ERBB40.34450559
114PRKCQ0.33906397
115PTK20.33854737
116GSK3A0.32661868
117MAP3K110.31869908
118LMTK20.31549545
119CDK60.31382074
120TBK10.31083006
121BCKDK0.29399079
122SRC0.28621922
123PRKCE0.28026553
124IGF1R0.27793381
125FYN0.26738396
126KIT0.26149085
127ABL10.25297982
128CAMK2G0.24479906
129PIM20.24207254
130PRKACA0.23759465
131MAP3K40.23436654
132MAPKAPK50.21777778
133PRKCA0.21656081
134ADRBK10.20639424
135MAP2K40.20352565
136AKT20.19430994
137PAK10.17669422
138TSSK60.17050502
139RET0.17008829
140MAP2K20.16894683
141PLK10.16515292
142CAMKK20.15853979
143ABL20.12883941
144RPS6KA20.12806186
145OXSR10.10445841
146BMPR20.10251382
147MAP2K70.09628916
148DYRK1A0.09287060
149CHEK20.09276536

Predicted pathways (KEGG)

RankGene SetZ-score
1Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.34163698
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.61775875
3Phenylalanine metabolism_Homo sapiens_hsa003603.57591454
4Salivary secretion_Homo sapiens_hsa049703.57149542
5Histidine metabolism_Homo sapiens_hsa003402.95775945
6Chemical carcinogenesis_Homo sapiens_hsa052042.77212635
7Tyrosine metabolism_Homo sapiens_hsa003502.53793184
8Selenocompound metabolism_Homo sapiens_hsa004502.36860272
9Fat digestion and absorption_Homo sapiens_hsa049752.30528882
10Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.18566334
11Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.03759642
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.01766153
13Fatty acid degradation_Homo sapiens_hsa000711.98848594
14beta-Alanine metabolism_Homo sapiens_hsa004101.97924800
15ECM-receptor interaction_Homo sapiens_hsa045121.78962921
16Pertussis_Homo sapiens_hsa051331.60346068
17Glycerolipid metabolism_Homo sapiens_hsa005611.58831994
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.57315622
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57307635
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.57047899
21Leukocyte transendothelial migration_Homo sapiens_hsa046701.45058117
22Tryptophan metabolism_Homo sapiens_hsa003801.44179619
23Tight junction_Homo sapiens_hsa045301.43623895
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.41259743
25Sphingolipid metabolism_Homo sapiens_hsa006001.38348102
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.37859210
27Linoleic acid metabolism_Homo sapiens_hsa005911.31859582
28Retinol metabolism_Homo sapiens_hsa008301.28516268
29Sulfur metabolism_Homo sapiens_hsa009201.26028951
30Glutathione metabolism_Homo sapiens_hsa004801.23692446
31Dilated cardiomyopathy_Homo sapiens_hsa054141.21429665
32Arachidonic acid metabolism_Homo sapiens_hsa005901.20941266
33Phagosome_Homo sapiens_hsa041451.18525870
34Focal adhesion_Homo sapiens_hsa045101.17747069
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16344276
36Renin secretion_Homo sapiens_hsa049241.15223150
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.14325968
38Gastric acid secretion_Homo sapiens_hsa049711.12310934
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10200780
40Caffeine metabolism_Homo sapiens_hsa002321.08750377
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00769231
42Adherens junction_Homo sapiens_hsa045200.99156639
43ABC transporters_Homo sapiens_hsa020100.98539309
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.93611567
45Olfactory transduction_Homo sapiens_hsa047400.93242230
46Complement and coagulation cascades_Homo sapiens_hsa046100.90531046
47Propanoate metabolism_Homo sapiens_hsa006400.90229175
48Malaria_Homo sapiens_hsa051440.87337771
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85301080
50Fatty acid elongation_Homo sapiens_hsa000620.84040528
51Viral myocarditis_Homo sapiens_hsa054160.80314915
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80260010
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.79017927
54Platelet activation_Homo sapiens_hsa046110.78621781
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74453800
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73253298
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69979078
58Fatty acid metabolism_Homo sapiens_hsa012120.66455274
59Lysosome_Homo sapiens_hsa041420.65687151
60Circadian rhythm_Homo sapiens_hsa047100.65138832
61Alzheimers disease_Homo sapiens_hsa050100.63579982
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62817981
63Rheumatoid arthritis_Homo sapiens_hsa053230.62799028
64Amoebiasis_Homo sapiens_hsa051460.61918953
65Carbon metabolism_Homo sapiens_hsa012000.61677114
66Mineral absorption_Homo sapiens_hsa049780.61420397
67Proteoglycans in cancer_Homo sapiens_hsa052050.58678994
68Starch and sucrose metabolism_Homo sapiens_hsa005000.57583471
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56870457
70Rap1 signaling pathway_Homo sapiens_hsa040150.54166795
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54069262
72Cardiac muscle contraction_Homo sapiens_hsa042600.52657409
73Notch signaling pathway_Homo sapiens_hsa043300.52506913
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51766044
75Toxoplasmosis_Homo sapiens_hsa051450.51581681
76Choline metabolism in cancer_Homo sapiens_hsa052310.51496592
77Staphylococcus aureus infection_Homo sapiens_hsa051500.50600032
78VEGF signaling pathway_Homo sapiens_hsa043700.48629396
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47462112
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46680869
81Vibrio cholerae infection_Homo sapiens_hsa051100.44112894
82Taste transduction_Homo sapiens_hsa047420.43736404
83Oxytocin signaling pathway_Homo sapiens_hsa049210.42130195
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40335358
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.39749784
86Pyruvate metabolism_Homo sapiens_hsa006200.39217417
87Hepatitis C_Homo sapiens_hsa051600.37470404
88TGF-beta signaling pathway_Homo sapiens_hsa043500.36486509
89Phototransduction_Homo sapiens_hsa047440.36280076
90Hippo signaling pathway_Homo sapiens_hsa043900.36246607
91GnRH signaling pathway_Homo sapiens_hsa049120.35617483
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.35111707
93Hedgehog signaling pathway_Homo sapiens_hsa043400.34883199
94Hematopoietic cell lineage_Homo sapiens_hsa046400.34809325
95Parkinsons disease_Homo sapiens_hsa050120.34472974
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34148907
97Salmonella infection_Homo sapiens_hsa051320.34081393
98PPAR signaling pathway_Homo sapiens_hsa033200.32323286
99Circadian entrainment_Homo sapiens_hsa047130.32040059
100Leishmaniasis_Homo sapiens_hsa051400.31882967
101Axon guidance_Homo sapiens_hsa043600.31790386
102Tuberculosis_Homo sapiens_hsa051520.31780853
103Fatty acid biosynthesis_Homo sapiens_hsa000610.31412461
104Melanogenesis_Homo sapiens_hsa049160.31381803
105Insulin resistance_Homo sapiens_hsa049310.31349013
106Peroxisome_Homo sapiens_hsa041460.31077982
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30704847
108Renin-angiotensin system_Homo sapiens_hsa046140.30667553
109Oxidative phosphorylation_Homo sapiens_hsa001900.30594577
110Glucagon signaling pathway_Homo sapiens_hsa049220.30395599
111Calcium signaling pathway_Homo sapiens_hsa040200.29453407
112Renal cell carcinoma_Homo sapiens_hsa052110.28113047
113Cocaine addiction_Homo sapiens_hsa050300.27987216
114Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.27721925
115Protein digestion and absorption_Homo sapiens_hsa049740.27678745
116Collecting duct acid secretion_Homo sapiens_hsa049660.26981338
117Thyroid hormone synthesis_Homo sapiens_hsa049180.26677516
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.24730147
119Huntingtons disease_Homo sapiens_hsa050160.24594068
120Metabolic pathways_Homo sapiens_hsa011000.24589625
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22872796
122Basal cell carcinoma_Homo sapiens_hsa052170.22676408
123Type I diabetes mellitus_Homo sapiens_hsa049400.21698449
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21428152
125Primary bile acid biosynthesis_Homo sapiens_hsa001200.20768192
126Arginine and proline metabolism_Homo sapiens_hsa003300.20320619
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.18754575
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.18283129
129Ovarian steroidogenesis_Homo sapiens_hsa049130.17742680
130Cyanoamino acid metabolism_Homo sapiens_hsa004600.17569590
131cAMP signaling pathway_Homo sapiens_hsa040240.16273320
132Phosphatidylinositol signaling system_Homo sapiens_hsa040700.15656589
133Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.15336614
134Allograft rejection_Homo sapiens_hsa053300.13942612
135Bile secretion_Homo sapiens_hsa049760.13864941
136Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.12664517
137Pancreatic secretion_Homo sapiens_hsa049720.12356408
138Autoimmune thyroid disease_Homo sapiens_hsa053200.12258089
139Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.10931090
140Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.10755964
141Fructose and mannose metabolism_Homo sapiens_hsa000510.10688129
142Jak-STAT signaling pathway_Homo sapiens_hsa046300.10351755
143Amphetamine addiction_Homo sapiens_hsa050310.10295515
144Endocytosis_Homo sapiens_hsa041440.09999566
145Prostate cancer_Homo sapiens_hsa052150.09928964
146Graft-versus-host disease_Homo sapiens_hsa053320.08511058
147Vitamin digestion and absorption_Homo sapiens_hsa049770.08183508
148Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.06958420
149Antigen processing and presentation_Homo sapiens_hsa046120.05875224
150N-Glycan biosynthesis_Homo sapiens_hsa005100.05292616
151Asthma_Homo sapiens_hsa053100.05277855
152RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.04596575
153Intestinal immune network for IgA production_Homo sapiens_hsa046720.04158671
154Nicotine addiction_Homo sapiens_hsa050330.02929922

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