BPIFB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the lipid transfer/lipopolysaccharide binding protein (LT/LBP) gene family. It is highly expressed in hypertrophic tonsils. This gene and three other members of the LT/LBP gene family form a cluster on the long arm of chromosome 20. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptide cross-linking (GO:0018149)9.54910236
2sarcoplasmic reticulum calcium ion transport (GO:0070296)8.92734979
3very-low-density lipoprotein particle assembly (GO:0034379)8.70475362
4negative regulation of fibrinolysis (GO:0051918)8.36285663
5plasma lipoprotein particle assembly (GO:0034377)8.35207995
6regulation of keratinocyte differentiation (GO:0045616)7.86307682
7protein-lipid complex assembly (GO:0065005)7.44334812
8peptidyl-glutamic acid carboxylation (GO:0017187)7.35267923
9protein carboxylation (GO:0018214)7.35267923
10intestinal cholesterol absorption (GO:0030299)7.31462625
11low-density lipoprotein particle remodeling (GO:0034374)7.29428778
12regulation of fibrinolysis (GO:0051917)7.09169855
13regulation of toll-like receptor 4 signaling pathway (GO:0034143)6.89195590
14regulation of apoptotic cell clearance (GO:2000425)6.87699874
15response to vitamin A (GO:0033189)6.81546940
16regulation of relaxation of muscle (GO:1901077)6.73449276
17regulation of protein activation cascade (GO:2000257)6.47327642
18regulation of complement activation (GO:0030449)6.43244131
19cholesterol efflux (GO:0033344)6.33965380
20plasma lipoprotein particle remodeling (GO:0034369)6.26150152
21protein-lipid complex remodeling (GO:0034368)6.26150152
22macromolecular complex remodeling (GO:0034367)6.26150152
23regulation of cholesterol esterification (GO:0010872)6.19714224
24plasma lipoprotein particle organization (GO:0071827)6.18860854
25purine nucleotide salvage (GO:0032261)6.12580057
26muscle organ morphogenesis (GO:0048644)5.95587278
27skeletal muscle contraction (GO:0003009)5.93141273
28regulation of secondary heart field cardioblast proliferation (GO:0003266)5.88150177
29regulation of cardioblast proliferation (GO:0003264)5.88150177
30protein-lipid complex subunit organization (GO:0071825)5.82405611
31long-chain fatty acid biosynthetic process (GO:0042759)5.80844725
32regulation of skeletal muscle contraction (GO:0014819)5.73327283
33keratinocyte differentiation (GO:0030216)5.67455444
34blood coagulation, intrinsic pathway (GO:0007597)5.65212270
35high-density lipoprotein particle remodeling (GO:0034375)5.55165942
36muscle filament sliding (GO:0030049)5.50786628
37actin-myosin filament sliding (GO:0033275)5.50786628
38regulation of skeletal muscle cell differentiation (GO:2001014)5.47968399
39regulation of plasminogen activation (GO:0010755)5.45632434
40plasma lipoprotein particle clearance (GO:0034381)5.39383384
41outer ear morphogenesis (GO:0042473)5.32275440
42regulation of cholesterol homeostasis (GO:2000188)5.28283250
43innate immune response in mucosa (GO:0002227)5.24754894
44coronary vasculature morphogenesis (GO:0060977)5.21451428
45intestinal absorption (GO:0050892)5.20269199
46reverse cholesterol transport (GO:0043691)5.16717124
47linoleic acid metabolic process (GO:0043651)5.09419518
48tooth mineralization (GO:0034505)5.09265350
49triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.08174305
50positive regulation of extracellular matrix organization (GO:1903055)4.77321140
51cellular response to epidermal growth factor stimulus (GO:0071364)4.75233313
52regulation of epidermal cell differentiation (GO:0045604)4.73814830
53lymph vessel development (GO:0001945)4.73030579
54negative regulation of protein activation cascade (GO:2000258)4.68636061
55cellular response to retinoic acid (GO:0071300)4.64787533
56regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.63873916
57regulation of bile acid biosynthetic process (GO:0070857)4.58135255
58low-density lipoprotein particle clearance (GO:0034383)4.54890149
59actin-mediated cell contraction (GO:0070252)4.43597955
60negative regulation of toll-like receptor signaling pathway (GO:0034122)4.43354008
61L-phenylalanine catabolic process (GO:0006559)4.41679209
62erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.41679209
63lung epithelium development (GO:0060428)4.39051297
64mucosal-associated lymphoid tissue development (GO:0048537)4.38349184
65Peyers patch development (GO:0048541)4.38349184
66negative regulation of cholesterol transport (GO:0032375)4.37083224
67negative regulation of sterol transport (GO:0032372)4.37083224
68proline metabolic process (GO:0006560)4.37049441
69regulation of cholesterol biosynthetic process (GO:0045540)4.30867274
70diacylglycerol metabolic process (GO:0046339)4.29155007
71negative regulation of thymocyte apoptotic process (GO:0070244)4.23996863
72lipoprotein metabolic process (GO:0042157)4.22953705
73L-phenylalanine metabolic process (GO:0006558)4.20017748
74erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.20017748
75regulation of penile erection (GO:0060405)4.09160804
76mucosal immune response (GO:0002385)4.08457445
77muscle cell fate commitment (GO:0042693)4.07096736
78histamine secretion (GO:0001821)4.05895723
79creatine metabolic process (GO:0006600)4.05040996
80complement activation, alternative pathway (GO:0006957)4.04723300
81cholesterol transport (GO:0030301)3.99093037
82sterol transport (GO:0015918)3.99093037
83cellular response to glucocorticoid stimulus (GO:0071385)3.96686019
84negative regulation of calcium ion transmembrane transport (GO:1903170)3.96091349
85negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.96091349
86cholesterol homeostasis (GO:0042632)3.91659461
87positive regulation of steroid metabolic process (GO:0045940)3.90047622
88response to epidermal growth factor (GO:0070849)3.90034042
89positive regulation of blood coagulation (GO:0030194)3.89471300
90positive regulation of hemostasis (GO:1900048)3.89471300
91negative regulation of complement activation (GO:0045916)3.89021865
92sterol homeostasis (GO:0055092)3.88022818
93regulation of extracellular matrix organization (GO:1903053)3.87273575
94epidermal cell differentiation (GO:0009913)3.87150935
95organ or tissue specific immune response (GO:0002251)3.86197321
96embryonic viscerocranium morphogenesis (GO:0048703)3.83106292
97regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.82420347
98positive regulation of hormone metabolic process (GO:0032352)3.82260945
99cellular response to corticosteroid stimulus (GO:0071384)3.82129434
100positive regulation of fatty acid biosynthetic process (GO:0045723)3.81943953
101phospholipid efflux (GO:0033700)3.81389568
102proline biosynthetic process (GO:0006561)3.79522927
103glutamate metabolic process (GO:0006536)3.76875450
104positive regulation of myotube differentiation (GO:0010831)3.74083770
105lipoxygenase pathway (GO:0019372)3.74061742
106positive regulation of lipoprotein lipase activity (GO:0051006)3.70560379
107positive regulation of triglyceride lipase activity (GO:0061365)3.70560379
108negative regulation of sodium ion transport (GO:0010766)3.69568903
109plasma membrane repair (GO:0001778)3.68728165
110nephron epithelium morphogenesis (GO:0072088)3.65013479
111nephron tubule morphogenesis (GO:0072078)3.65013479
112regulation of humoral immune response (GO:0002920)3.61825386
113embryonic retina morphogenesis in camera-type eye (GO:0060059)3.61393968
114mature B cell differentiation involved in immune response (GO:0002313)3.60737723
115acute-phase response (GO:0006953)3.59722355
116positive regulation of hormone biosynthetic process (GO:0046886)3.59097405
117pinocytosis (GO:0006907)3.58579404
118positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.55945116
119cranial nerve morphogenesis (GO:0021602)3.54680525
120protein activation cascade (GO:0072376)3.51961077
121positive regulation of coagulation (GO:0050820)3.51886991
122fibrinolysis (GO:0042730)3.51451535
123establishment of skin barrier (GO:0061436)3.49506656
124positive regulation of protein depolymerization (GO:1901881)3.48397024
125striated muscle contraction (GO:0006941)3.48322228
126modified amino acid transport (GO:0072337)3.46296853
127negative regulation of blood coagulation (GO:0030195)3.46029443
128negative regulation of hemostasis (GO:1900047)3.46029443
129tricarboxylic acid cycle (GO:0006099)3.44228199
130actin filament-based movement (GO:0030048)3.41826077
131trivalent inorganic anion homeostasis (GO:0072506)3.40920950
132phosphate ion homeostasis (GO:0055062)3.40920950
133response to vitamin E (GO:0033197)3.36441318
134myotube differentiation (GO:0014902)3.32398829
135cell proliferation involved in metanephros development (GO:0072203)3.32010384
136regulation of germinal center formation (GO:0002634)3.31577690
137regulation of norepinephrine secretion (GO:0014061)3.30356103
138regulation of non-canonical Wnt signaling pathway (GO:2000050)3.30257282
139regulation of epidermis development (GO:0045682)3.29147736
140negative regulation of B cell apoptotic process (GO:0002903)3.26790693
141peptidyl-glutamic acid modification (GO:0018200)3.26000605
142lipid homeostasis (GO:0055088)3.24631247
143negative regulation of norepinephrine secretion (GO:0010700)3.22566039
144complement activation, classical pathway (GO:0006958)3.22025106
145negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.21048312
146response to prostaglandin (GO:0034694)3.20180177
147positive regulation of skeletal muscle tissue development (GO:0048643)3.18775604
148negative regulation of coagulation (GO:0050819)3.18508508
149cellular zinc ion homeostasis (GO:0006882)3.18147752
150positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.17253645
151positive regulation of T cell differentiation in thymus (GO:0033089)3.16884169
152positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.16102599
153renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.15674319
154vitamin transmembrane transport (GO:0035461)3.13004381
155cellular anion homeostasis (GO:0030002)3.12956534
156negative regulation of lipase activity (GO:0060192)3.11846421
157regulation of cholesterol metabolic process (GO:0090181)3.11399979
158regulation of water loss via skin (GO:0033561)3.11263500
159histamine transport (GO:0051608)3.10141821
160positive regulation of dendritic spine morphogenesis (GO:0061003)3.10066799
161myofibril assembly (GO:0030239)3.09682065
162transepithelial transport (GO:0070633)3.08363105
163drinking behavior (GO:0042756)3.07563253
164regulation of extracellular matrix disassembly (GO:0010715)3.06346957
165negative regulation of humoral immune response (GO:0002921)3.06043777
166artery smooth muscle contraction (GO:0014824)3.06025026
167desmosome organization (GO:0002934)3.03708109
168response to muscle activity (GO:0014850)3.02627742
169keratinization (GO:0031424)20.6609715
170bundle of His cell to Purkinje myocyte communication (GO:0086069)2.99513440
171purine nucleobase biosynthetic process (GO:0009113)2.97011143
172sarcomere organization (GO:0045214)2.96240945
173regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.93965352
174adenosine metabolic process (GO:0046085)2.93960544
175nucleotide salvage (GO:0043173)2.93853622
176skeletal muscle fiber development (GO:0048741)2.88965655
177regulation of calcium ion transmembrane transport (GO:1903169)2.83270202
178regulation of calcium ion transmembrane transporter activity (GO:1901019)2.83270202
179aspartate family amino acid catabolic process (GO:0009068)2.81719992
180skeletal muscle adaptation (GO:0043501)2.81543973
181regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.80769057
182pharyngeal system development (GO:0060037)2.79418798
183regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.79157652
184purine deoxyribonucleotide catabolic process (GO:0009155)2.78762768
185carnitine shuttle (GO:0006853)2.78466539
186otic vesicle formation (GO:0030916)2.67629455
187mature B cell differentiation (GO:0002335)2.66799246
188muscle contraction (GO:0006936)2.65469945
189regulation of acyl-CoA biosynthetic process (GO:0050812)2.64271376
190negative regulation of ion transmembrane transporter activity (GO:0032413)2.63326151
191positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.62742182
192negative regulation of circadian rhythm (GO:0042754)2.60904726
193NADH metabolic process (GO:0006734)2.59727041
194negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.59688369
1952-oxoglutarate metabolic process (GO:0006103)2.59026743
196cochlea morphogenesis (GO:0090103)2.58294433
197negative regulation of digestive system process (GO:0060457)2.57995836
198cell wall macromolecule catabolic process (GO:0016998)14.8793801
199cell wall macromolecule metabolic process (GO:0044036)14.8793801
200negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)13.6042537

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF652_21678463_ChIP-ChIP_ZR75-1_Human8.73233151
2TP63_17297297_ChIP-ChIP_HaCaT_Human8.66001264
3FOXA2_19822575_ChIP-Seq_HepG2_Human4.82774853
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.08847763
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.74880394
6CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.56796871
7HNF4A_19822575_ChIP-Seq_HepG2_Human3.33437742
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.08497018
9ESR1_21235772_ChIP-Seq_MCF-7_Human3.05663685
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.99285095
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.97867863
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.94427426
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.90129759
14HIF1A_21447827_ChIP-Seq_MCF-7_Human2.66201956
15ESR1_15608294_ChIP-ChIP_MCF-7_Human2.37582966
16EGR1_23403033_ChIP-Seq_LIVER_Mouse2.34575687
17CTCF_27219007_Chip-Seq_Bcells_Human2.32588182
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.32335992
19ESR2_21235772_ChIP-Seq_MCF-7_Human2.26080352
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.23195622
21CTCF_20526341_ChIP-Seq_ESCs_Human2.18078180
22RARG_19884340_ChIP-ChIP_MEFs_Mouse2.11991035
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.06737241
24CDX2_19796622_ChIP-Seq_MESCs_Mouse2.05759652
25TCF4_18268006_ChIP-ChIP_LS174T_Human2.02027260
26SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.93076892
27FOXO3_23340844_ChIP-Seq_DLD1_Human1.90943600
28ERG_20517297_ChIP-Seq_VCAP_Human1.88986737
29SALL4_18804426_ChIP-ChIP_XEN_Mouse1.87353453
30VDR_22108803_ChIP-Seq_LS180_Human1.83728579
31CDX2_20551321_ChIP-Seq_CACO-2_Human1.81794884
32GATA4_25053715_ChIP-Seq_YYC3_Human1.81603888
33TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.79837791
34AR_21909140_ChIP-Seq_LNCAP_Human1.79650358
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76776577
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.72405313
37ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.63803531
38PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.53542629
39ZNF263_19887448_ChIP-Seq_K562_Human1.52776319
40AR_21572438_ChIP-Seq_LNCaP_Human1.52314667
41RXR_22158963_ChIP-Seq_LIVER_Mouse1.46468392
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.46046199
43NFIB_24661679_ChIP-Seq_LUNG_Mouse1.45796361
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.43258047
45GATA6_25053715_ChIP-Seq_YYC3_Human1.42560061
46ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.41959070
47P63_26484246_Chip-Seq_KERATINOCYTES_Human1.41868469
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41820222
49RACK7_27058665_Chip-Seq_MCF-7_Human1.39923663
50GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.38977542
51SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.37684368
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37638177
53SOX2_27498859_Chip-Seq_STOMACH_Mouse1.37055606
54GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.36343949
55PPARA_22158963_ChIP-Seq_LIVER_Mouse1.35037504
56CTNNB1_20460455_ChIP-Seq_HCT116_Human1.32504759
57TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32322272
58EZH2_22144423_ChIP-Seq_EOC_Human1.31252068
59BCOR_27268052_Chip-Seq_Bcells_Human1.27576427
60EGR1_19032775_ChIP-ChIP_M12_Human1.26401840
61SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25352794
62GATA6_21074721_ChIP-Seq_CACO-2_Human1.25202707
63CLOCK_20551151_ChIP-Seq_293T_Human1.24752913
64* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.24323145
65DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24201450
66NANOG_20526341_ChIP-Seq_ESCs_Human1.24180632
67SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22982586
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21654490
69FOXH1_21741376_ChIP-Seq_ESCs_Human1.18839218
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18442736
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18440982
72CJUN_26792858_Chip-Seq_BT549_Human1.18099850
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17912321
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.17098344
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14007262
76FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.12049327
77RXR_22108803_ChIP-Seq_LS180_Human1.09594422
78LXR_22292898_ChIP-Seq_THP-1_Human1.09425530
79KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09222152
80POU5F1_16518401_ChIP-PET_MESCs_Mouse1.08461925
81OCT1_27270436_Chip-Seq_PROSTATE_Human1.08360893
82TBX20_22328084_ChIP-Seq_HEART_Mouse1.08123002
83TBX20_22080862_ChIP-Seq_HEART_Mouse1.08123002
84STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07751113
85SMC4_20622854_ChIP-Seq_HELA_Human1.07747892
86YY1_22570637_ChIP-Seq_MALME-3M_Human1.07501643
87P68_20966046_ChIP-Seq_HELA_Human1.07093892
88ERG_21242973_ChIP-ChIP_JURKAT_Human1.05735568
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.05482289
90SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.04883069
91FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03343757
92SOX2_20726797_ChIP-Seq_SW620_Human1.03050363
93SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02557414
94EZH2_27294783_Chip-Seq_ESCs_Mouse1.02215711
95KDM2B_26808549_Chip-Seq_DND41_Human1.01815441
96CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01333191
97LXR_22158963_ChIP-Seq_LIVER_Mouse1.01047654
98WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00926801
99RARA_24833708_ChIP-Seq_LIVER_Mouse1.00722177
100ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99851190
101TP53_22127205_ChIP-Seq_IMR90_Human0.99803328
102MTF2_20144788_ChIP-Seq_MESCs_Mouse0.99703867
103CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99388933
104CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99341760
105STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.99062828
106PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97942876
107PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96467718
108BCL6_27268052_Chip-Seq_Bcells_Human0.95750647
109RXRA_24833708_ChIP-Seq_LIVER_Mouse0.95667287
110GATA3_24758297_ChIP-Seq_MCF-7_Human0.95061998
111SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.94958240
112SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.94573941
113PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94034087
114JARID2_20075857_ChIP-Seq_MESCs_Mouse0.93238677
115P53_21459846_ChIP-Seq_SAOS-2_Human0.91470950
116SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90853847
117SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90853847
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90584634
119MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.90515018
120RARB_27405468_Chip-Seq_BRAIN_Mouse0.90186914
121RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.89847011
122TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89766712
123PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89556484
124AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88986544
125RNF2_18974828_ChIP-Seq_MESCs_Mouse0.88271000
126EZH2_18974828_ChIP-Seq_MESCs_Mouse0.88271000
127RARB_24833708_ChIP-Seq_LIVER_Mouse0.88092819
128CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87921430
129RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87880748
130KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87342946
131ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87251735
132POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87178664
133SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.87073889
134TP63_22573176_ChIP-Seq_HFKS_Human0.86977413
135SOX2_21211035_ChIP-Seq_LN229_Human0.86542405
136NANOG_21062744_ChIP-ChIP_HESCs_Human0.86437712
137ERA_21632823_ChIP-Seq_H3396_Human0.85425418
138RAC3_21632823_ChIP-Seq_H3396_Human0.85399826
139EZH2_27304074_Chip-Seq_ESCs_Mouse0.85249612
140GATA3_21878914_ChIP-Seq_MCF-7_Human0.84748371
141TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84740827
142KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.84687694
143ELK3_25401928_ChIP-Seq_HUVEC_Human0.83219631
144IKZF1_21737484_ChIP-ChIP_HCT116_Human0.83188961
145SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82847993
146RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.82450120
147SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.81577427
148TP53_20018659_ChIP-ChIP_R1E_Mouse0.80551192
149JARID2_20064375_ChIP-Seq_MESCs_Mouse0.80145885
150RUNX1_27514584_Chip-Seq_MCF-7_Human0.80050503
151EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.79847367
152TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79299693
153UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.79029342
154PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.78471984
155SOX11_22085726_ChIP-Seq_ESNs_Mouse0.76634983
156ATF3_27146783_Chip-Seq_COLON_Human0.72894458
157NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.72289850
158CSB_26484114_Chip-Seq_FIBROBLAST_Human0.71714438
159KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71318546
160SOX17_20123909_ChIP-Seq_XEN_Mouse0.70167950
161FOXA1_25552417_ChIP-Seq_VCAP_Human0.69536705
162SPI1_26923725_Chip-Seq_HPCs_Mouse0.68769996
163SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.67570797
164SOX9_24532713_ChIP-Seq_HFSC_Mouse0.66879202
165KDM2B_26808549_Chip-Seq_K562_Human0.66007913
166EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.65000266
167GATA1_19941827_ChIP-Seq_MEL_Mouse0.64413111
168HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.63845920
169SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.62781236

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting6.81296029
2MP0002234_abnormal_pharynx_morphology5.47837754
3MP0000751_myopathy5.11726802
4MP0003646_muscle_fatigue4.90856790
5MP0002796_impaired_skin_barrier4.88665282
6MP0005275_abnormal_skin_tensile4.21254379
7MP0005365_abnormal_bile_salt4.18280506
8MP0000749_muscle_degeneration4.00246846
9MP0000467_abnormal_esophagus_morphology3.74756219
10MP0001666_abnormal_nutrient_absorption3.54191568
11MP0003123_paternal_imprinting3.51902552
12MP0000566_synostosis3.44156855
13MP0002837_dystrophic_cardiac_calcinosis3.40282050
14MP0000762_abnormal_tongue_morphology3.30620917
15MP0004145_abnormal_muscle_electrophysio3.07143823
16MP0009697_abnormal_copulation2.87423739
17MP0000747_muscle_weakness2.79407418
18MP0005501_abnormal_skin_physiology2.66900642
19MP0002089_abnormal_postnatal_growth/wei2.60785358
20MP0003172_abnormal_lysosome_physiology2.60737546
21MP0000759_abnormal_skeletal_muscle2.56898075
22MP0002106_abnormal_muscle_physiology2.55851541
23MP0000678_abnormal_parathyroid_gland2.42851507
24MP0002095_abnormal_skin_pigmentation2.30032904
25MP0003121_genomic_imprinting2.26097303
26MP0009780_abnormal_chondrocyte_physiolo2.25784858
27MP0004130_abnormal_muscle_cell2.25234430
28MP0005408_hypopigmentation2.23800911
29MP0003252_abnormal_bile_duct2.20079185
30MP0006054_spinal_hemorrhage2.15635040
31MP0001243_abnormal_dermal_layer2.14563301
32MP0001915_intracranial_hemorrhage2.13678619
33MP0004185_abnormal_adipocyte_glucose2.12756063
34MP0004087_abnormal_muscle_fiber2.12182458
35MP0005369_muscle_phenotype2.07306685
36MP0005058_abnormal_lysosome_morphology2.06257503
37MP0000750_abnormal_muscle_regeneration2.05478295
38MP0004036_abnormal_muscle_relaxation2.02671043
39MP0002132_abnormal_respiratory_system1.98271043
40MP0000733_abnormal_muscle_development1.92801493
41MP0000371_diluted_coat_color1.88275300
42MP0002269_muscular_atrophy1.86764137
43MP0003868_abnormal_feces_composition1.85790193
44MP0010234_abnormal_vibrissa_follicle1.83016199
45MP0005620_abnormal_muscle_contractility1.76008800
46MP0005409_darkened_coat_color1.75137733
47MP0002332_abnormal_exercise_endurance1.70712166
48MP0003705_abnormal_hypodermis_morpholog1.63573359
49MP0000609_abnormal_liver_physiology1.61882303
50MP0005257_abnormal_intraocular_pressure1.58823259
51MP0010368_abnormal_lymphatic_system1.57482611
52MP0005666_abnormal_adipose_tissue1.55212502
53MP0002118_abnormal_lipid_homeostasis1.54108249
54MP0001879_abnormal_lymphatic_vessel1.52616739
55MP0004270_analgesia1.52491351
56MP0002249_abnormal_larynx_morphology1.51573426
57MP0005330_cardiomyopathy1.46968020
58MP0006036_abnormal_mitochondrial_physio1.45548590
59MP0003567_abnormal_fetal_cardiomyocyte1.43826716
60MP0009384_cardiac_valve_regurgitation1.42207185
61MP0003806_abnormal_nucleotide_metabolis1.39017792
62MP0005167_abnormal_blood-brain_barrier1.38985209
63MP0004264_abnormal_extraembryonic_tissu1.38720739
64MP0005266_abnormal_metabolism1.36022468
65MP0004272_abnormal_basement_membrane1.32178897
66MP0002933_joint_inflammation1.31285399
67MP0000470_abnormal_stomach_morphology1.28633047
68MP0000639_abnormal_adrenal_gland1.27708928
69MP0009840_abnormal_foam_cell1.26884820
70MP0002127_abnormal_cardiovascular_syste1.26179614
71MP0002972_abnormal_cardiac_muscle1.25834397
72MP0005332_abnormal_amino_acid1.22267388
73MP0002254_reproductive_system_inflammat1.21680999
74MP0003315_abnormal_perineum_morphology1.19843094
75MP0004084_abnormal_cardiac_muscle1.16973185
76MP0002938_white_spotting1.15703787
77MP0001270_distended_abdomen1.14322224
78MP0003183_abnormal_peptide_metabolism1.13137074
79MP0005076_abnormal_cell_differentiation1.11148396
80MP0003942_abnormal_urinary_system1.10919130
81MP0010771_integument_phenotype1.10829715
82MP0000579_abnormal_nail_morphology1.06734255
83MP0001216_abnormal_epidermal_layer1.05842668
84MP0004947_skin_inflammation1.03382202
85MP0005636_abnormal_mineral_homeostasis1.01355103
86MP0000598_abnormal_liver_morphology1.00966104
87MP0003950_abnormal_plasma_membrane1.00718836
88MP0003115_abnormal_respiratory_system1.00420255
89MP0004233_abnormal_muscle_weight0.99897528
90MP0005375_adipose_tissue_phenotype0.98635475
91MP0005464_abnormal_platelet_physiology0.98564985
92MP0001661_extended_life_span0.98520575
93MP0004215_abnormal_myocardial_fiber0.98433899
94MP0005084_abnormal_gallbladder_morpholo0.97157425
95MP0002075_abnormal_coat/hair_pigmentati0.95420458
96MP0003878_abnormal_ear_physiology0.94516151
97MP0005377_hearing/vestibular/ear_phenot0.94516151
98MP0004484_altered_response_of0.92488870
99MP0005670_abnormal_white_adipose0.88810545
100MP0000049_abnormal_middle_ear0.86045418
101MP0000003_abnormal_adipose_tissue0.84903587
102MP0002108_abnormal_muscle_morphology0.83881436
103MP0000647_abnormal_sebaceous_gland0.83552405
104MP0005451_abnormal_body_composition0.83242130
105MP0003943_abnormal_hepatobiliary_system0.82402401
106MP0002139_abnormal_hepatobiliary_system0.81042704
107MP0003221_abnormal_cardiomyocyte_apopto0.80174679
108MP0003656_abnormal_erythrocyte_physiolo0.78530998
109MP0002971_abnormal_brown_adipose0.78121917
110MP0000604_amyloidosis0.77879133
111MP0009642_abnormal_blood_homeostasis0.77653603
112MP0001299_abnormal_eye_distance/0.76807807
113MP0003879_abnormal_hair_cell0.76468611
114MP0004043_abnormal_pH_regulation0.75871772
115MP0001544_abnormal_cardiovascular_syste0.75352550
116MP0005385_cardiovascular_system_phenoty0.75352550
117MP0008260_abnormal_autophagy0.74623397
118MP0001191_abnormal_skin_condition0.73253175
119MP0005410_abnormal_fertilization0.72306240
120MP0003136_yellow_coat_color0.71496120
121MP0002092_abnormal_eye_morphology0.71254004
122MP0001324_abnormal_eye_pigmentation0.71220094
123MP0005379_endocrine/exocrine_gland_phen0.70123451
124MP0009115_abnormal_fat_cell0.69554206
125MP0005220_abnormal_exocrine_pancreas0.69323720
126MP0010630_abnormal_cardiac_muscle0.68794128
127MP0003890_abnormal_embryonic-extraembry0.67144568
128MP0000920_abnormal_myelination0.67050530
129MP0003941_abnormal_skin_development0.66795081
130MP0008438_abnormal_cutaneous_collagen0.66624195
131MP0001756_abnormal_urination0.66596107
132MP0004019_abnormal_vitamin_homeostasis0.65223487
133MP0005164_abnormal_response_to0.64814606
134MP0008961_abnormal_basal_metabolism0.64179084
135MP0003453_abnormal_keratinocyte_physiol0.63975295
136MP0008569_lethality_at_weaning0.63531527
137MP0001286_abnormal_eye_development0.63222008
138MP0002160_abnormal_reproductive_system0.63119527
139MP0005085_abnormal_gallbladder_physiolo0.62813211
140MP0003632_abnormal_nervous_system0.62228761
141MP0000367_abnormal_coat/_hair0.62040933
142MP0000372_irregular_coat_pigmentation0.61996854
143MP0004858_abnormal_nervous_system0.61739827
144MP0003329_amyloid_beta_deposits0.61569285
145MP0000427_abnormal_hair_cycle0.61246625
146MP0002078_abnormal_glucose_homeostasis0.61120828
147MP0001293_anophthalmia0.60729197
148MP0001177_atelectasis0.59878620
149MP0009931_abnormal_skin_appearance0.59639730
150MP0002909_abnormal_adrenal_gland0.58991469
151MP0004859_abnormal_synaptic_plasticity0.58442956
152MP0000681_abnormal_thyroid_gland0.57983444
153MP0006138_congestive_heart_failure0.57780196
154MP0002233_abnormal_nose_morphology0.57774108
155MP0009643_abnormal_urine_homeostasis0.57163119
156MP0000767_abnormal_smooth_muscle0.57080946
157MP0003566_abnormal_cell_adhesion0.56419066
158MP0000858_altered_metastatic_potential0.56219539
159MP0005448_abnormal_energy_balance0.55173505
160MP0003953_abnormal_hormone_level0.54695088
161MP0002166_altered_tumor_susceptibility0.54489710
162MP0009250_abnormal_appendicular_skeleto0.54205019
163MP0001186_pigmentation_phenotype0.54131844
164MP0003137_abnormal_impulse_conducting0.53013199
165MP0006292_abnormal_olfactory_placode0.52589346
166MP0005360_urolithiasis0.52437282
167MP0000534_abnormal_ureter_morphology0.52058293
168MP0001764_abnormal_homeostasis0.51802316
169MP0004883_abnormal_blood_vessel0.51569636
170MP0005319_abnormal_enzyme/_coenzyme0.49635346
171MP0002086_abnormal_extraembryonic_tissu0.49350239
172MP0002876_abnormal_thyroid_physiology0.49135507
173MP0008775_abnormal_heart_ventricle0.48316249
174MP0003195_calcinosis0.47437049
175MP0003755_abnormal_palate_morphology0.46642616
176MP0000343_altered_response_to0.46319573
177MP0002060_abnormal_skin_morphology0.45343405
178MP0003075_altered_response_to0.45025015
179MP0008875_abnormal_xenobiotic_pharmacok0.44523151
180MP0000613_abnormal_salivary_gland0.43323684
181MP0000013_abnormal_adipose_tissue0.43138146
182MP0010329_abnormal_lipoprotein_level0.41313048

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)7.21601782
2Distal arthrogryposis (HP:0005684)6.55259986
3Exercise-induced myalgia (HP:0003738)6.46896857
4Muscle fiber inclusion bodies (HP:0100299)6.37746423
5Joint hemorrhage (HP:0005261)6.35755148
6Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.35719957
7Nemaline bodies (HP:0003798)5.70260846
8Round ear (HP:0100830)5.44716723
9Hypobetalipoproteinemia (HP:0003563)5.33144482
10Complement deficiency (HP:0004431)5.18444588
11Ulnar deviation of the wrist (HP:0003049)5.16060045
12Abnormality of the common coagulation pathway (HP:0010990)5.01287622
13Exercise-induced muscle cramps (HP:0003710)5.00475064
14Muscle hypertrophy of the lower extremities (HP:0008968)4.96055698
15Type 1 muscle fiber predominance (HP:0003803)4.88395356
16Small epiphyses (HP:0010585)4.83591334
17Calf muscle hypertrophy (HP:0008981)4.81335697
18Increased connective tissue (HP:0009025)4.80976658
19Difficulty running (HP:0009046)4.78392151
20Absent phalangeal crease (HP:0006109)4.66912134
21Myopathic facies (HP:0002058)4.54959484
22Calcaneovalgus deformity (HP:0001848)4.54072488
23Myoglobinuria (HP:0002913)4.46407575
24Hypercholesterolemia (HP:0003124)4.38522359
25Glomerulonephritis (HP:0000099)4.33662345
26Xanthomatosis (HP:0000991)4.23631549
27Menorrhagia (HP:0000132)4.19466305
28Autoimmune thrombocytopenia (HP:0001973)4.18951807
29Muscle fiber splitting (HP:0003555)4.14965909
30Hemorrhage of the eye (HP:0011885)4.14211303
31Increased IgE level (HP:0003212)4.08227158
32Unilateral renal agenesis (HP:0000122)4.07342018
33Hyporeflexia of lower limbs (HP:0002600)4.05695574
34Abnormality of carpal bone ossification (HP:0006257)4.01762720
35Deformed tarsal bones (HP:0008119)4.01327111
36Broad alveolar ridges (HP:0000187)3.92059908
37Rimmed vacuoles (HP:0003805)3.87917832
38Abnormal finger flexion creases (HP:0006143)3.87114052
39Acanthocytosis (HP:0001927)3.80343687
40Abnormality of complement system (HP:0005339)3.75689547
41Increased variability in muscle fiber diameter (HP:0003557)3.70207282
42Abnormality of aromatic amino acid family metabolism (HP:0004338)3.59531730
43Congenital malformation of the right heart (HP:0011723)3.56573200
44Double outlet right ventricle (HP:0001719)3.56573200
45Abnormal tarsal ossification (HP:0008369)3.56444391
46Asymmetry of the thorax (HP:0001555)3.56177672
47Mesangial abnormality (HP:0001966)3.51324301
48Abnormality of skeletal muscle fiber size (HP:0012084)3.49796737
49Systemic lupus erythematosus (HP:0002725)3.49518142
50Autoimmune hemolytic anemia (HP:0001890)3.47437221
51Epiphyseal dysplasia (HP:0002656)3.44842613
52Flat acetabular roof (HP:0003180)3.43394975
53Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.40125399
54Hypolipoproteinemia (HP:0010981)3.38408314
55Broad palm (HP:0001169)3.35012252
56Spontaneous abortion (HP:0005268)3.31610516
57Abnormality of the calf musculature (HP:0001430)3.27353482
58Pancreatic islet-cell hyperplasia (HP:0004510)3.19564304
59Hypoplasia of the capital femoral epiphysis (HP:0003090)3.16412477
60Distal lower limb muscle weakness (HP:0009053)3.15580105
61EMG: myopathic abnormalities (HP:0003458)3.15554812
62Right ventricular cardiomyopathy (HP:0011663)3.14401984
63Vaginal fistula (HP:0004320)3.12069244
64Purpura (HP:0000979)3.10650500
65Abnormality of the aortic arch (HP:0012303)3.10373762
66Epidermoid cyst (HP:0200040)3.09524978
67Abnormality of the parathyroid morphology (HP:0011766)3.09310148
68Muscle stiffness (HP:0003552)3.07784420
69Cholelithiasis (HP:0001081)3.07059363
70Paralysis (HP:0003470)3.07022873
71Myotonia (HP:0002486)3.03063961
72Abnormal hand bone ossification (HP:0010660)3.02470934
73Abnormal ossification of hand bones (HP:0005921)3.02012321
74Congenital ichthyosiform erythroderma (HP:0007431)3.01370601
75Areflexia of lower limbs (HP:0002522)2.99957521
76Irregular epiphyses (HP:0010582)2.98221902
77Hyperthyroidism (HP:0000836)2.96074358
78Vascular calcification (HP:0004934)2.95614965
79Rhabdomyolysis (HP:0003201)2.92639447
80Distal lower limb amyotrophy (HP:0008944)2.90603343
81Hepatoblastoma (HP:0002884)2.86079471
82Abnormal gallbladder morphology (HP:0012437)2.80178683
83Difficulty climbing stairs (HP:0003551)2.76430874
84Cupped ribs (HP:0000887)2.75282834
85Abnormality of the calcaneus (HP:0008364)2.74653306
86Abnormality of B cell number (HP:0010975)2.74462777
87B lymphocytopenia (HP:0010976)2.74462777
88Abnormality of the nasal septum (HP:0000419)2.74401667
89Abnormality of the lumbar spine (HP:0100712)2.72204091
90Abnormality of the wing of the ilium (HP:0011867)2.70035908
91Flared iliac wings (HP:0002869)2.69882595
92Neck muscle weakness (HP:0000467)2.67592535
93Hypophosphatemic rickets (HP:0004912)2.60134647
94Gingival bleeding (HP:0000225)2.59150219
95Cardiovascular calcification (HP:0011915)2.56391339
96Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.56347769
97Absent epiphyses (HP:0010577)2.56347769
98Facial diplegia (HP:0001349)2.51785784
99Alacrima (HP:0000522)2.48795151
100Limited elbow extension (HP:0001377)2.45923328
101Diastasis recti (HP:0001540)2.45025678
102Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.43558456
103Frequent falls (HP:0002359)2.40603566
104Hypoplastic ischia (HP:0003175)2.38801021
105Protrusio acetabuli (HP:0003179)2.38728805
106Enlarged kidneys (HP:0000105)2.36361743
107Lower limb amyotrophy (HP:0007210)2.32949670
108Increased serum pyruvate (HP:0003542)2.32940778
109Mitral stenosis (HP:0001718)2.29008042
110Tetany (HP:0001281)2.27935459
111Abnormal foot bone ossification (HP:0010675)2.26608420
112Hypoplastic left heart (HP:0004383)2.25694377
113Short palpebral fissure (HP:0012745)2.25156740
114Potter facies (HP:0002009)2.22571919
115Facial shape deformation (HP:0011334)2.22571919
116Myocardial infarction (HP:0001658)2.21274014
117Skin nodule (HP:0200036)2.21125237
118Hepatocellular carcinoma (HP:0001402)2.20019819
119Wide nose (HP:0000445)2.19791219
120Abnormality of glycolysis (HP:0004366)2.18687380
121Abnormality of the acetabulum (HP:0003170)2.18501135
122Thrombophlebitis (HP:0004418)2.18305049
123Pigmentary retinal degeneration (HP:0001146)2.18173246
124Hypoalphalipoproteinemia (HP:0003233)2.14059463
125Conjugated hyperbilirubinemia (HP:0002908)2.10953808
126Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.10799803
127Shoulder girdle muscle weakness (HP:0003547)2.10382766
128Abnormality of pain sensation (HP:0010832)2.09887802
129Impaired pain sensation (HP:0007328)2.09887802
130Abnormality of the ischium (HP:0003174)2.09759565
131Thyroiditis (HP:0100646)2.06690132
132Arthropathy (HP:0003040)2.06647755
133Pelvic girdle muscle weakness (HP:0003749)2.06494340
134Hypoglycemic coma (HP:0001325)2.03691694
135Amblyopia (HP:0000646)2.03338871
136Scapular winging (HP:0003691)2.02184733
137Abnormality of the alveolar ridges (HP:0006477)2.01840471
138Oral leukoplakia (HP:0002745)11.6075431
139Deep venous thrombosis (HP:0002625)10.9679715
140Delusions (HP:0000746)1.99789240
141Supernumerary spleens (HP:0009799)1.99441082
142Abnormality of the pancreatic islet cells (HP:0006476)1.98282053
143Abnormality of endocrine pancreas physiology (HP:0012093)1.98282053
144Abnormality of the musculature of the pelvis (HP:0001469)1.98063299
145Abnormality of the hip-girdle musculature (HP:0001445)1.98063299
146Metaphyseal irregularity (HP:0003025)1.98012972
147Abnormality of the intrinsic pathway (HP:0010989)1.97730120
148Seborrheic dermatitis (HP:0001051)1.97664240
149Abnormality of monocarboxylic acid metabolism (HP:0010996)1.97375726
150Fat malabsorption (HP:0002630)1.97183437
151Severe combined immunodeficiency (HP:0004430)1.96861528
152Nephritis (HP:0000123)1.96575246
153Neonatal death (HP:0003811)1.95948878
154Renal duplication (HP:0000075)1.92932880
155Nasal speech (HP:0001611)1.92898957
156Abnormality of the lacrimal duct (HP:0011481)1.91747197
157Neonatal short-limb short stature (HP:0008921)1.91233987
158Foot dorsiflexor weakness (HP:0009027)1.91180721
159Muscular dystrophy (HP:0003560)1.90455014
160Peritonitis (HP:0002586)1.89887726
161Hypertensive crisis (HP:0100735)1.88357222
162Widely patent fontanelles and sutures (HP:0004492)1.88121860
163Poikilocytosis (HP:0004447)1.86648715
164Rectal fistula (HP:0100590)1.86327648
165Rectovaginal fistula (HP:0000143)1.86327648
166Decreased lacrimation (HP:0000633)1.86208279
167Hyperkalemia (HP:0002153)1.85886379
168Nephroblastoma (Wilms tumor) (HP:0002667)1.84823314
169Ulnar deviation of finger (HP:0009465)1.84758898
170Intrahepatic cholestasis (HP:0001406)1.83897546
171Abnormality of the pubic bones (HP:0003172)1.82883852
172Exotropia (HP:0000577)1.82837337
173Coxa vara (HP:0002812)1.80246772
174Achilles tendon contracture (HP:0001771)1.80166377
175Ectropion (HP:0000656)1.79550520
176Abnormality of the peritoneum (HP:0002585)1.78222674
177Abnormality of the gallbladder (HP:0005264)1.78062373
178Intestinal fistula (HP:0100819)1.76844270
179Bifid scrotum (HP:0000048)1.75670271
180Supernumerary ribs (HP:0005815)1.74861388
181Gout (HP:0001997)1.73772292
182Abnormality of the Achilles tendon (HP:0005109)1.72987754
183Rickets (HP:0002748)1.72823548
184Abnormality of the foot musculature (HP:0001436)1.72649449
185Abnormality of the vitreous humor (HP:0004327)1.70895504
186Corneal erosion (HP:0200020)1.69628009
187Abnormality of the shoulder girdle musculature (HP:0001435)1.67815000
188Wrist flexion contracture (HP:0001239)1.67492829
189Palmoplantar keratoderma (HP:0000982)1.67456011
190Metatarsus adductus (HP:0001840)1.64791244
191Aplasia/Hypoplasia of the thymus (HP:0010515)1.63051192
192Hypoplastic heart (HP:0001961)1.62963486
193Woolly hair (HP:0002224)1.62209498
194Proximal amyotrophy (HP:0007126)1.62122476
195Malignant hyperthermia (HP:0002047)1.61042464
196Combined immunodeficiency (HP:0005387)1.60194184
197Abnormality of the tricuspid valve (HP:0001702)1.58540239
198Truncus arteriosus (HP:0001660)1.57793246

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR47.25890884
2FGFR35.27166000
3PIK3CG5.22415740
4ICK4.02311987
5OBSCN3.87307250
6CDK123.42029776
7TYRO33.27435459
8PHKG23.14838269
9PHKG13.14838269
10NEK12.86823307
11PDK42.66926695
12PDK32.66926695
13TRIB32.65858338
14MAP2K32.45072277
15FGFR22.36204737
16PINK12.09578578
17TTN10.9815290
18SIK21.94216816
19AKT31.82669375
20PDK21.78583076
21BCKDK1.70547144
22DMPK1.49813158
23PKN21.41183666
24MAPKAPK31.35677871
25NME11.35160158
26MAP2K41.34785714
27TAOK11.34490671
28EIF2AK11.26241415
29MAP3K71.24176306
30EPHA21.18738333
31MAPK121.10156433
32ERBB21.04025384
33SGK2231.02442961
34SGK4941.02442961
35CDK70.99642492
36MAP3K30.96287124
37MAP2K60.95740668
38NEK20.92585496
39CDC42BPA0.91929841
40IRAK30.91788985
41KSR20.85778760
42RIPK10.82968854
43FER0.80198626
44MAP3K110.79743751
45MATK0.77567012
46SGK30.77262800
47RPS6KB10.75123065
48CSNK1E0.68634571
49CAMK2A0.67778683
50BRSK10.66832542
51MAP3K90.66394050
52MAPK110.65797426
53NEK90.64980146
54BCR0.64559889
55EPHB10.63982782
56SGK20.63981812
57WNK40.63939800
58NTRK20.63819227
59ERN10.63622563
60PRKD10.62185977
61BRD40.61974228
62PAK60.61282071
63PTK60.58845970
64ERBB30.58158066
65CAMK1D0.54140609
66RPS6KB20.54078982
67MARK20.53196242
68PIK3CA0.52773923
69MTOR0.51441185
70CDK80.51033124
71LATS20.48212099
72MAP3K60.47695954
73SMG10.46961759
74LRRK20.46346974
75MAP3K10.45252244
76FLT30.43410430
77TAOK20.42761860
78CAMK2G0.41855751
79MAP3K20.41732193
80TYK20.41723873
81PRKCH0.41637920
82WNK10.40672225
83SGK10.40391774
84PDK10.39766342
85PDGFRB0.38782693
86CSF1R0.38781701
87PTK20.37691994
88BRSK20.37534358
89LIMK10.37334252
90PDPK10.37319888
91PKN10.36392739
92MAP3K50.36221094
93PRKAA20.34634299
94EPHA40.34274133
95SRC0.33728777
96ITK0.32701471
97CSNK2A20.32658676
98NTRK30.31687478
99MAP2K10.30957321
100DYRK1B0.30399915
101PAK30.30079671
102CDK40.29858036
103MELK0.28218153
104CSNK1D0.28103139
105BMX0.27913684
106YES10.27125355
107AKT20.26664156
108CDK190.26440868
109MAPKAPK20.25301041
110NTRK10.25166165
111CDK60.24953135
112RPS6KA30.24761074
113MAPK30.24716660
114IGF1R0.24557654
115TRPM70.23853522
116MUSK0.23011564
117MARK10.22982624
118CAMK1G0.22908534
119PRKACA0.22530697
120CDK10.22435592
121DDR20.22121168
122TGFBR20.22083887
123TIE10.21961814
124CSNK2A10.21322426
125CDK90.21257853
126EEF2K0.20670582
127ILK0.20401197
128RET0.20264021
129PRKG10.20182898
130ROCK20.19896388
131PDGFRA0.19811089
132PRKCZ0.19449085
133CAMKK10.19409524
134PRKACG0.18841320
135MAPK40.18272374
136MAPKAPK50.18254225
137MAPK10.17771167
138MAPK140.17096055
139ALK0.17015622
140GSK3B0.16654585
141ROCK10.16534630
142PRKACB0.15990865
143PRKD30.15894499
144CDK50.15858245
145FGFR10.15527544
146MINK10.15500051
147MST1R0.14846556
148STK390.14639868
149JAK20.14148120
150DAPK20.13017810
151PTK2B0.12168655
152CAMK40.11445916
153SIK10.10893363
154PRKAA10.10777602
155FGR0.10496882
156EPHB20.09688882
157PAK20.09664275
158LATS10.09505682
159FYN0.08885957

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046106.17248304
2Salivary secretion_Homo sapiens_hsa049704.41387115
3Fat digestion and absorption_Homo sapiens_hsa049754.03369654
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.95509372
5Phenylalanine metabolism_Homo sapiens_hsa003603.91503405
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.55308539
7Steroid biosynthesis_Homo sapiens_hsa001003.24936132
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.13172895
9Glycerolipid metabolism_Homo sapiens_hsa005612.69289181
10Vitamin digestion and absorption_Homo sapiens_hsa049772.37028245
11Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.27716564
12Other glycan degradation_Homo sapiens_hsa005112.22550063
13Histidine metabolism_Homo sapiens_hsa003402.10980576
14Tyrosine metabolism_Homo sapiens_hsa003502.10513364
15beta-Alanine metabolism_Homo sapiens_hsa004102.05974093
16Staphylococcus aureus infection_Homo sapiens_hsa051502.00593353
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.93620068
18Fatty acid degradation_Homo sapiens_hsa000711.93547900
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.89238368
20Propanoate metabolism_Homo sapiens_hsa006401.84988671
21Carbon metabolism_Homo sapiens_hsa012001.84096743
22Arginine biosynthesis_Homo sapiens_hsa002201.70308495
23Cardiac muscle contraction_Homo sapiens_hsa042601.68292262
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.62027499
25Alzheimers disease_Homo sapiens_hsa050101.60819229
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.57717088
27ABC transporters_Homo sapiens_hsa020101.53514919
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.53439660
29Parkinsons disease_Homo sapiens_hsa050121.49513455
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45125255
31Nitrogen metabolism_Homo sapiens_hsa009101.43962060
32Oxidative phosphorylation_Homo sapiens_hsa001901.41200214
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.40058285
34Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.34716571
35N-Glycan biosynthesis_Homo sapiens_hsa005101.31220867
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30525156
37Glucagon signaling pathway_Homo sapiens_hsa049221.29626068
38Fatty acid metabolism_Homo sapiens_hsa012121.28864233
39Renin-angiotensin system_Homo sapiens_hsa046141.27493155
40Biosynthesis of amino acids_Homo sapiens_hsa012301.27485420
41Pyruvate metabolism_Homo sapiens_hsa006201.27175807
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25529430
43Chemical carcinogenesis_Homo sapiens_hsa052041.24992860
44Starch and sucrose metabolism_Homo sapiens_hsa005001.23869013
45Olfactory transduction_Homo sapiens_hsa047401.21887268
46Vitamin B6 metabolism_Homo sapiens_hsa007501.16898683
47Dilated cardiomyopathy_Homo sapiens_hsa054141.15611310
48Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.11602382
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09848163
50Thyroid hormone synthesis_Homo sapiens_hsa049181.09740102
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.08908628
52Phototransduction_Homo sapiens_hsa047441.06871602
53Renin secretion_Homo sapiens_hsa049241.03944319
54Butanoate metabolism_Homo sapiens_hsa006501.00785442
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00576253
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.96341395
57GnRH signaling pathway_Homo sapiens_hsa049120.95036641
58Gastric acid secretion_Homo sapiens_hsa049710.94333707
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.93891082
60Lysine degradation_Homo sapiens_hsa003100.93625315
61Oxytocin signaling pathway_Homo sapiens_hsa049210.92619988
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92273594
63Insulin signaling pathway_Homo sapiens_hsa049100.88855715
64Long-term potentiation_Homo sapiens_hsa047200.86685308
65Arginine and proline metabolism_Homo sapiens_hsa003300.82233271
66Circadian entrainment_Homo sapiens_hsa047130.81631147
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78928297
68Calcium signaling pathway_Homo sapiens_hsa040200.78143279
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77317134
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76564012
71One carbon pool by folate_Homo sapiens_hsa006700.75045327
72Insulin resistance_Homo sapiens_hsa049310.72838149
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.72534701
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72191526
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.71988882
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70454807
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70130738
78Fatty acid elongation_Homo sapiens_hsa000620.69787941
79Prion diseases_Homo sapiens_hsa050200.68188631
80ECM-receptor interaction_Homo sapiens_hsa045120.67466423
81PPAR signaling pathway_Homo sapiens_hsa033200.67322611
82Tryptophan metabolism_Homo sapiens_hsa003800.65334179
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64656009
84Glioma_Homo sapiens_hsa052140.64191232
85Sulfur metabolism_Homo sapiens_hsa009200.61323165
86Retinol metabolism_Homo sapiens_hsa008300.60979905
87Huntingtons disease_Homo sapiens_hsa050160.60711789
88Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60110050
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.59546704
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58799038
91Mineral absorption_Homo sapiens_hsa049780.58169877
92Amphetamine addiction_Homo sapiens_hsa050310.57590292
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.57333014
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56769916
95VEGF signaling pathway_Homo sapiens_hsa043700.55900997
96Arachidonic acid metabolism_Homo sapiens_hsa005900.55867629
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.53033907
98Non-small cell lung cancer_Homo sapiens_hsa052230.52389425
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.51775715
100Melanogenesis_Homo sapiens_hsa049160.50923188
101Sphingolipid metabolism_Homo sapiens_hsa006000.47630674
102Long-term depression_Homo sapiens_hsa047300.44406876
103AMPK signaling pathway_Homo sapiens_hsa041520.43269732
104Estrogen signaling pathway_Homo sapiens_hsa049150.43064634
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42789648
106Pertussis_Homo sapiens_hsa051330.42470911
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.40737056
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38211102
109Galactose metabolism_Homo sapiens_hsa000520.37962315
110Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37227946
111Bile secretion_Homo sapiens_hsa049760.36993841
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36737825
113Fructose and mannose metabolism_Homo sapiens_hsa000510.36107083
114Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35091744
115Dopaminergic synapse_Homo sapiens_hsa047280.34633669
116Serotonergic synapse_Homo sapiens_hsa047260.34425986
117Fatty acid biosynthesis_Homo sapiens_hsa000610.32534765
118Adherens junction_Homo sapiens_hsa045200.32033235
119Pentose phosphate pathway_Homo sapiens_hsa000300.31494265
120Tight junction_Homo sapiens_hsa045300.29288059
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.28018784
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25629144
123Glutathione metabolism_Homo sapiens_hsa004800.25515339
124Type II diabetes mellitus_Homo sapiens_hsa049300.25350220
125Proteoglycans in cancer_Homo sapiens_hsa052050.24317263
126Circadian rhythm_Homo sapiens_hsa047100.23277843
127Wnt signaling pathway_Homo sapiens_hsa043100.22987440
128Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22477712
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.21750362
130Linoleic acid metabolism_Homo sapiens_hsa005910.21733014
131Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21533383
132mTOR signaling pathway_Homo sapiens_hsa041500.20452010
133Peroxisome_Homo sapiens_hsa041460.20285066
134Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.20211999
135Insulin secretion_Homo sapiens_hsa049110.19494523
136Metabolic pathways_Homo sapiens_hsa011000.18789736
137Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.18415712
138Platelet activation_Homo sapiens_hsa046110.18412491
139GABAergic synapse_Homo sapiens_hsa047270.18347519
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.18094051
141HIF-1 signaling pathway_Homo sapiens_hsa040660.16894512
142Focal adhesion_Homo sapiens_hsa045100.16614558
143Lysosome_Homo sapiens_hsa041420.16612898
144Cholinergic synapse_Homo sapiens_hsa047250.14977449
145Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.13852929
146Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.13780489
147Choline metabolism in cancer_Homo sapiens_hsa052310.13624664
148PI3K-Akt signaling pathway_Homo sapiens_hsa041510.12373997
149Bladder cancer_Homo sapiens_hsa052190.09949443
150African trypanosomiasis_Homo sapiens_hsa051430.09520988

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