BPIFB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to cilium (GO:0061512)8.38901493
2folic acid transport (GO:0015884)8.13463222
3protein neddylation (GO:0045116)7.71325929
4tachykinin receptor signaling pathway (GO:0007217)6.96815260
5folic acid metabolic process (GO:0046655)6.67689896
6positive regulation of digestive system process (GO:0060456)6.63263130
7positive regulation of cellular amide metabolic process (GO:0034250)6.53026006
8neutrophil activation involved in immune response (GO:0002283)6.19952902
9ethanol oxidation (GO:0006069)6.11874468
10reverse cholesterol transport (GO:0043691)5.97874835
11antibacterial humoral response (GO:0019731)5.83807617
12response to misfolded protein (GO:0051788)5.76216670
13microglial cell activation (GO:0001774)5.71391380
14one-carbon compound transport (GO:0019755)5.54906156
15negative regulation of protein oligomerization (GO:0032460)5.47357704
16thrombin receptor signaling pathway (GO:0070493)5.45920336
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.43536609
18antimicrobial humoral response (GO:0019730)5.41973344
19positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc5.40134589
20regulation of cholesterol biosynthetic process (GO:0045540)5.24686910
21glial cell proliferation (GO:0014009)5.23045693
22serotonin receptor signaling pathway (GO:0007210)5.09407944
23fusion of sperm to egg plasma membrane (GO:0007342)5.00209654
24blood coagulation, intrinsic pathway (GO:0007597)4.90533307
25regulation of sodium ion transmembrane transport (GO:1902305)4.83453884
26regulation of integrin-mediated signaling pathway (GO:2001044)4.83001043
27sequestering of actin monomers (GO:0042989)4.77914836
28negative regulation of heart rate (GO:0010459)4.72858797
29ethanol metabolic process (GO:0006067)4.71030592
30response to interferon-beta (GO:0035456)4.62391209
31activation of protein kinase A activity (GO:0034199)4.61498242
32regulation of beta-amyloid formation (GO:1902003)4.58531339
33negative regulation of norepinephrine secretion (GO:0010700)4.57324895
34regulation of platelet activation (GO:0010543)4.57031342
35uronic acid metabolic process (GO:0006063)4.41431668
36glucuronate metabolic process (GO:0019585)4.41431668
37adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.34482964
38protein insertion into membrane (GO:0051205)4.28367549
39regulation of amyloid precursor protein catabolic process (GO:1902991)4.26520559
40adenosine receptor signaling pathway (GO:0001973)4.25516748
41platelet degranulation (GO:0002576)4.24687859
42cellular glucuronidation (GO:0052695)4.21369389
43regulation of platelet aggregation (GO:0090330)4.12819837
44epoxygenase P450 pathway (GO:0019373)4.12033706
45low-density lipoprotein particle remodeling (GO:0034374)4.07769283
46beta-amyloid metabolic process (GO:0050435)4.00383111
47platelet aggregation (GO:0070527)3.92559696
48negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.91332161
49negative regulation of protein localization to cell surface (GO:2000009)3.88086770
50myelin maintenance (GO:0043217)3.86551743
51regulation of sodium ion transmembrane transporter activity (GO:2000649)3.86158101
52negative regulation of thymocyte apoptotic process (GO:0070244)3.83598932
53prostaglandin biosynthetic process (GO:0001516)3.82729175
54prostanoid biosynthetic process (GO:0046457)3.82729175
55regulation of sodium ion transport (GO:0002028)3.81314852
56lipoxygenase pathway (GO:0019372)3.81219810
57renal absorption (GO:0070293)3.81049925
58regulation of protein homooligomerization (GO:0032462)3.78140565
59exogenous drug catabolic process (GO:0042738)3.76617487
60negative regulation of cytosolic calcium ion concentration (GO:0051481)3.72179555
61plasma membrane fusion (GO:0045026)3.71722223
62negative regulation of platelet activation (GO:0010544)3.70493236
63L-phenylalanine catabolic process (GO:0006559)3.68637744
64erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.68637744
65leukocyte migration involved in inflammatory response (GO:0002523)3.67342792
66regulation of neuron projection regeneration (GO:0070570)3.63137919
67regulation of axon regeneration (GO:0048679)3.63137919
68gas transport (GO:0015669)3.58232093
69flavonoid metabolic process (GO:0009812)3.57979075
70tonic smooth muscle contraction (GO:0014820)3.53938028
71water-soluble vitamin biosynthetic process (GO:0042364)3.52801193
72angiogenesis involved in wound healing (GO:0060055)3.52744719
73cAMP biosynthetic process (GO:0006171)3.48509381
74mitochondrial calcium ion transport (GO:0006851)3.48225877
75membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.47768823
76lateral ventricle development (GO:0021670)3.47520315
77extracellular fibril organization (GO:0043206)3.47464697
78primary alcohol catabolic process (GO:0034310)3.46550237
79neutrophil activation (GO:0042119)3.46222489
80negative regulation of astrocyte differentiation (GO:0048712)3.44677856
81positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.41408882
82modified amino acid transport (GO:0072337)3.39568224
83mating behavior (GO:0007617)3.39122685
84purinergic nucleotide receptor signaling pathway (GO:0035590)3.38244272
85regulation of cholesterol metabolic process (GO:0090181)3.36627463
86cyclooxygenase pathway (GO:0019371)3.32018966
87megakaryocyte development (GO:0035855)3.31880702
88positive regulation of mast cell activation (GO:0033005)3.29588689
89negative regulation of neurological system process (GO:0031645)3.28585088
90fibrinolysis (GO:0042730)3.28363914
91tyrosine metabolic process (GO:0006570)3.26956581
92regulation of heart rate by cardiac conduction (GO:0086091)3.26610880
93hormone catabolic process (GO:0042447)3.24094384
94fibroblast migration (GO:0010761)3.20318211
95sulfur amino acid catabolic process (GO:0000098)3.19096860
96granulocyte activation (GO:0036230)3.18931652
97positive regulation of endothelial cell differentiation (GO:0045603)3.17948692
98regulation of macrophage derived foam cell differentiation (GO:0010743)3.16699700
99alkaloid metabolic process (GO:0009820)3.16089866
100regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:23.15200903
101negative regulation of microtubule polymerization (GO:0031115)3.15116826
102drug catabolic process (GO:0042737)3.14232672
103water transport (GO:0006833)3.13892985
104phospholipid homeostasis (GO:0055091)3.13842781
105endothelium development (GO:0003158)3.13504803
106negative regulation of homotypic cell-cell adhesion (GO:0034111)3.10918728
107fibril organization (GO:0097435)3.10356312
108G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.09883853
109negative regulation of viral entry into host cell (GO:0046597)3.09733932
110positive regulation of macrophage differentiation (GO:0045651)3.08018011
111B cell mediated immunity (GO:0019724)3.07273747
112negative regulation of response to food (GO:0032096)3.05893663
113negative regulation of appetite (GO:0032099)3.05893663
114relaxation of cardiac muscle (GO:0055119)3.02050134
115cellular potassium ion homeostasis (GO:0030007)3.01953621
116negative regulation of T cell apoptotic process (GO:0070233)3.00823084
117positive regulation of cAMP-mediated signaling (GO:0043950)3.00783114
118immunoglobulin mediated immune response (GO:0016064)3.00762298
119sensory perception of smell (GO:0007608)23.8303851
120platelet activation (GO:0030168)2.99025375
121membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.98626515
122regulation of chemokine-mediated signaling pathway (GO:0070099)2.98598897
123erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.96397368
124L-phenylalanine metabolic process (GO:0006558)2.96397368
125high-density lipoprotein particle remodeling (GO:0034375)2.95781899
126cellular copper ion homeostasis (GO:0006878)2.94684434
127phagocytosis, engulfment (GO:0006911)2.93522892
128regulation of norepinephrine secretion (GO:0014061)2.92960023
129cofactor transport (GO:0051181)2.90251815
130artery smooth muscle contraction (GO:0014824)2.89241613
131regulation of sensory perception of pain (GO:0051930)2.88902615
132regulation of sensory perception (GO:0051931)2.88902615
133regulation of inclusion body assembly (GO:0090083)2.88711983
134cardiac conduction (GO:0061337)2.88648118
135negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.87786767
136response to interferon-alpha (GO:0035455)2.86788984
137regulation of cellular amide metabolic process (GO:0034248)2.86737716
138negative regulation of hemostasis (GO:1900047)2.86023040
139negative regulation of blood coagulation (GO:0030195)2.86023040
140omega-hydroxylase P450 pathway (GO:0097267)2.83484526
141toxin metabolic process (GO:0009404)2.82361881
142purinergic receptor signaling pathway (GO:0035587)2.82316581
143negative regulation of catecholamine secretion (GO:0033604)2.82300320
144positive regulation of hormone biosynthetic process (GO:0046886)2.80887703
145regulation of MHC class II biosynthetic process (GO:0045346)2.80123401
146mitochondrial calcium ion homeostasis (GO:0051560)2.78036311
147histamine secretion (GO:0001821)2.77878065
148negative regulation of heart contraction (GO:0045822)2.76827480
149protein localization to endosome (GO:0036010)2.74695733
150regulation of cilium movement (GO:0003352)2.74445121
151fluid transport (GO:0042044)2.73563499
152potassium ion homeostasis (GO:0055075)2.73303341
153dopamine receptor signaling pathway (GO:0007212)2.72337942
154camera-type eye morphogenesis (GO:0048593)2.72064290
155layer formation in cerebral cortex (GO:0021819)2.69895915
156negative regulation of lipase activity (GO:0060192)2.68224917
157atrial cardiac muscle cell action potential (GO:0086014)2.64126649
158multicellular organismal water homeostasis (GO:0050891)2.64031473
159ovulation cycle (GO:0042698)2.63844000
160regulation of cardioblast proliferation (GO:0003264)2.62998978
161regulation of secondary heart field cardioblast proliferation (GO:0003266)2.62998978
162L-ascorbic acid metabolic process (GO:0019852)2.62350855
163cellular response to glucagon stimulus (GO:0071377)2.59998031
164cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.59682491
165membrane repolarization during action potential (GO:0086011)2.59480077
166negative regulation of B cell mediated immunity (GO:0002713)2.56811856
167negative regulation of immunoglobulin mediated immune response (GO:0002890)2.56811856
168negative regulation of sodium ion transport (GO:0010766)2.56453661
169endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.54892201
170cilium morphogenesis (GO:0060271)2.52635134
171cell communication involved in cardiac conduction (GO:0086065)2.50858591
172regulation of steroid hormone biosynthetic process (GO:0090030)2.50282319
173forebrain neuron development (GO:0021884)2.48630846
174response to vitamin A (GO:0033189)2.48617409
175sodium ion export (GO:0071436)2.47167722
176positive regulation of steroid biosynthetic process (GO:0010893)2.46209196
177peptide biosynthetic process (GO:0043043)2.46138526
178cAMP metabolic process (GO:0046058)2.43203933
179response to caffeine (GO:0031000)2.42326331
180regulation of digestive system process (GO:0044058)2.41563680
181negative regulation of humoral immune response (GO:0002921)2.36672270
182glutamate secretion (GO:0014047)2.33171209
183ectoderm development (GO:0007398)2.32916499
184cellular potassium ion transport (GO:0071804)2.32713712
185potassium ion transmembrane transport (GO:0071805)2.32713712
186positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.30482997
187calcium-mediated signaling using intracellular calcium source (GO:0035584)2.29904523
188chemical homeostasis within a tissue (GO:0048875)2.29745861
189semaphorin-plexin signaling pathway (GO:0071526)2.24146942
190regulation of female gonad development (GO:2000194)2.24127665
191positive regulation of macrophage cytokine production (GO:0060907)2.21052861
192positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.20227833
193cellular response to electrical stimulus (GO:0071257)2.19617369
194axonal fasciculation (GO:0007413)2.18645292
195cytoskeletal anchoring at plasma membrane (GO:0007016)2.16346031
196apoptotic cell clearance (GO:0043277)2.16163362
197cardiac muscle cell action potential involved in contraction (GO:0086002)2.16048563
198sensory perception of chemical stimulus (GO:0007606)12.9460764
199chemosensory behavior (GO:0007635)11.7122641

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.00777745
2LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.87902607
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.80924952
4SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.60586507
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.35669114
6DROSHA_22980978_ChIP-Seq_HELA_Human3.10231666
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.94086698
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.87058220
9HTT_18923047_ChIP-ChIP_STHdh_Human2.79115861
10ZNF263_19887448_ChIP-Seq_K562_Human2.67005070
11RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.61980686
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.53935459
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.52682855
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.52578294
15SCL_19346495_ChIP-Seq_HPC-7_Human2.48472501
16GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.43051551
17LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.41196112
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.39873731
19GATA1_19941826_ChIP-Seq_K562_Human2.34800244
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.29144050
21EGR1_23403033_ChIP-Seq_LIVER_Mouse2.23319692
22ERG_21242973_ChIP-ChIP_JURKAT_Human2.21207102
23IRF8_22096565_ChIP-ChIP_GC-B_Human2.18499737
24BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.15010311
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.07333154
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.04321901
27GBX2_23144817_ChIP-Seq_PC3_Human2.01831013
28GATA2_19941826_ChIP-Seq_K562_Human1.97658307
29CLOCK_20551151_ChIP-Seq_293T_Human1.87152761
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.83288837
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.81973355
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.81688567
33RNF2_18974828_ChIP-Seq_MESCs_Mouse1.81688567
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.81623803
35ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.79022781
36LXR_22158963_ChIP-Seq_LIVER_Mouse1.78435378
37SRY_22984422_ChIP-ChIP_TESTIS_Rat1.76887732
38RXR_22158963_ChIP-Seq_LIVER_Mouse1.76690965
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.71310088
40EZH2_22144423_ChIP-Seq_EOC_Human1.70448090
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.68441230
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66777278
43SPI1_23127762_ChIP-Seq_K562_Human1.65565270
44KDM2B_26808549_Chip-Seq_K562_Human1.65541401
45GATA1_19941827_ChIP-Seq_MEL_Mouse1.64158890
46SALL4_22934838_ChIP-ChIP_CD34+_Human1.63061244
47GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.62502661
48IRF8_27001747_Chip-Seq_BMDM_Mouse1.60741081
49SOX2_27498859_Chip-Seq_STOMACH_Mouse1.58550465
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.56396342
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.55574632
52SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.51233604
53ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48951853
54MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.47904849
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47112107
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.44206047
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43277364
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.42911750
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.42592149
60NANOG_19829295_ChIP-Seq_ESCs_Human1.41552907
61SOX2_19829295_ChIP-Seq_ESCs_Human1.41552907
62MTF2_20144788_ChIP-Seq_MESCs_Mouse1.41354385
63SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.41227152
64SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.40774494
65PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40486780
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39685207
67LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38549788
68RBPJ_21746931_ChIP-Seq_IB4_Human1.38229660
69SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38153220
70NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36953665
71PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.36500089
72RARG_19884340_ChIP-ChIP_MEFs_Mouse1.35881887
73ETV2_25802403_ChIP-Seq_MESCs_Mouse1.35722442
74TAF15_26573619_Chip-Seq_HEK293_Human1.32936173
75AHR_22903824_ChIP-Seq_MCF-7_Human1.32740449
76STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32141124
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30467006
78RUNX1_27514584_Chip-Seq_MCF-7_Human1.30264486
79STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29481265
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28268596
81ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26156728
82CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.25300125
83SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24904804
84SOX2_20726797_ChIP-Seq_SW620_Human1.24880192
85POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24467450
86AR_20517297_ChIP-Seq_VCAP_Human1.24417163
87RARB_27405468_Chip-Seq_BRAIN_Mouse1.24087153
88GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.23886653
89LXR_22292898_ChIP-Seq_THP-1_Human1.23338695
90FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.23113727
91NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22624970
92GATA6_21074721_ChIP-Seq_CACO-2_Human1.22418926
93GATA3_26560356_Chip-Seq_TH2_Human1.22275208
94WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21242345
95JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20339614
96SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20168238
97EP300_21415370_ChIP-Seq_HL-1_Mouse1.19547910
98HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19177159
99SPI1_20517297_ChIP-Seq_HL60_Human1.18747104
100GATA3_24758297_ChIP-Seq_MCF-7_Human1.18335082
101RING1B_27294783_Chip-Seq_NPCs_Mouse1.18131090
102HNFA_21074721_ChIP-Seq_CACO-2_Human1.17252774
103PPARA_22158963_ChIP-Seq_LIVER_Mouse1.16117025
104PHF8_20622853_ChIP-Seq_HELA_Human1.15400445
105RUNX_20019798_ChIP-Seq_JUKART_Human1.15001544
106ERG_20517297_ChIP-Seq_VCAP_Human1.14782799
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14716859
108CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.14342974
109P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13711726
110SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13682483
111TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13387547
112ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.13022263
113JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12821918
114VDR_22108803_ChIP-Seq_LS180_Human1.12406470
115GATA3_27048872_Chip-Seq_THYMUS_Human1.11809703
116AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.11641323
117RING1B_27294783_Chip-Seq_ESCs_Mouse1.10356104
118RUNX1_22412390_ChIP-Seq_EML_Mouse1.10051646
119MYB_26560356_Chip-Seq_TH2_Human1.09943639
120STAT1_20625510_ChIP-Seq_HELA_Human1.07455139
121STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07339579
122MYC_19915707_ChIP-ChIP_AK7_Human1.05974807
123WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05922340
124MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05868715
125ARNT_22903824_ChIP-Seq_MCF-7_Human1.05025548
126MYB_21317192_ChIP-Seq_ERMYB_Mouse1.04749527
127FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04709603
128CTCF_27219007_Chip-Seq_Bcells_Human1.04668196
129ELK4_26923725_Chip-Seq_MESODERM_Mouse1.03705061
130PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.02207407
131NFYA_21822215_ChIP-Seq_K562_Human1.01046704
132EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00876240
133FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00373731
134SMAD4_21741376_ChIP-Seq_HESCs_Human1.00157843
135EZH2_27294783_Chip-Seq_ESCs_Mouse0.99163752
136NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99130050
137NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99130050
138RNF2_27304074_Chip-Seq_ESCs_Mouse0.98930511
139RACK7_27058665_Chip-Seq_MCF-7_Human0.98651410
140SMRT_27268052_Chip-Seq_Bcells_Human0.98079711
141STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.97846479
142IGF1R_20145208_ChIP-Seq_DFB_Human0.97705065
143BCAT_22108803_ChIP-Seq_LS180_Human0.97409113
144FOXA1_25329375_ChIP-Seq_VCAP_Human0.96808827
145FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96808827
146ISL1_27105846_Chip-Seq_CPCs_Mouse0.96762984
147FOXO3_23340844_ChIP-Seq_DLD1_Human0.96511779
148GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.96487317
149ATF3_27146783_Chip-Seq_COLON_Human0.96372589
150KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96367981
151GATA1_19941827_ChIP-Seq_MEL86_Mouse0.96330374
152KDM2B_26808549_Chip-Seq_JURKAT_Human0.96194585
153GATA4_25053715_ChIP-Seq_YYC3_Human0.95609757
154SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94859878
155CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94751077
156ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94260773
157GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93935979
158CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93449758
159ETV1_20927104_ChIP-Seq_GIST48_Human0.93400402
160CDX2_20551321_ChIP-Seq_CACO-2_Human0.93128959
161GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93077116
162RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93012138
163GATA3_21878914_ChIP-Seq_MCF-7_Human0.92321295
164TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92265334
165PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91568897
166OCT1_27270436_Chip-Seq_PROSTATE_Human0.91366345
167NFYB_21822215_ChIP-Seq_K562_Human0.90100659
168AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89924858
169ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89829261
170SMAD4_21741376_ChIP-Seq_EPCs_Human0.89508567
171KLF5_25053715_ChIP-Seq_YYC3_Human0.89222454
172ESR1_21235772_ChIP-Seq_MCF-7_Human0.89208448
173KDM2B_26808549_Chip-Seq_DND41_Human0.89097547
174PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89055465
175NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.88727053
176DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88198479
177JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88191321
178RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.87769863
179HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87724971
180FOXA2_19822575_ChIP-Seq_HepG2_Human0.87523150
181EZH2_27304074_Chip-Seq_ESCs_Mouse0.86903380
182GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86654054
183THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86570125
184SMC4_20622854_ChIP-Seq_HELA_Human0.86277220
185TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.86080076
186NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.86049562
187FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86023324
188GATA1_22025678_ChIP-Seq_K562_Human0.85555981
189FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.85134784
190E2F1_20622854_ChIP-Seq_HELA_Human0.84797265

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010386_abnormal_urinary_bladder7.50682931
2MP0005499_abnormal_olfactory_system6.42176500
3MP0005394_taste/olfaction_phenotype6.42176500
4MP0005464_abnormal_platelet_physiology6.36784416
5MP0008875_abnormal_xenobiotic_pharmacok5.45129549
6MP0008789_abnormal_olfactory_epithelium5.39856987
7MP0000537_abnormal_urethra_morphology4.94035658
8MP0008004_abnormal_stomach_pH4.45361061
9MP0002735_abnormal_chemical_nociception2.80476703
10MP0001853_heart_inflammation2.75365964
11MP0001835_abnormal_antigen_presentation2.66127097
12MP0003724_increased_susceptibility_to2.42947231
13MP0000343_altered_response_to2.30009830
14MP0002736_abnormal_nociception_after2.25733292
15MP0005083_abnormal_biliary_tract2.25648099
16MP0003806_abnormal_nucleotide_metabolis2.25412011
17MP0002148_abnormal_hypersensitivity_rea2.21505588
18MP0005671_abnormal_response_to2.01869617
19MP0001984_abnormal_olfaction13.9039145
20MP0010030_abnormal_orbit_morphology1.82206829
21MP0003011_delayed_dark_adaptation1.79404899
22MP0000538_abnormal_urinary_bladder1.76107633
23MP0009785_altered_susceptibility_to1.69697346
24MP0000490_abnormal_crypts_of1.63141253
25MP0010234_abnormal_vibrissa_follicle1.61796230
26MP0003436_decreased_susceptibility_to1.59433580
27MP0000230_abnormal_systemic_arterial1.54806885
28MP0005365_abnormal_bile_salt1.48963252
29MP0010155_abnormal_intestine_physiology1.47182683
30MP0002233_abnormal_nose_morphology1.46809152
31MP0005332_abnormal_amino_acid1.44529352
32MP0005000_abnormal_immune_tolerance1.39756773
33MP0002139_abnormal_hepatobiliary_system1.38817844
34MP0003879_abnormal_hair_cell1.38672590
35MP0002909_abnormal_adrenal_gland1.35650857
36MP0003638_abnormal_response/metabolism_1.35594304
37MP0009840_abnormal_foam_cell1.34638908
38MP0001879_abnormal_lymphatic_vessel1.32559233
39MP0002822_catalepsy1.30188129
40MP0001970_abnormal_pain_threshold1.26135116
41MP0003938_abnormal_ear_development1.26052282
42MP0001533_abnormal_skeleton_physiology1.25705789
43MP0009765_abnormal_xenobiotic_induced1.24770984
44MP0005084_abnormal_gallbladder_morpholo1.23768447
45MP0003329_amyloid_beta_deposits1.22894128
46MP0009763_increased_sensitivity_to1.20845179
47MP0001968_abnormal_touch/_nociception1.19151225
48MP0000249_abnormal_blood_vessel1.16590220
49MP0001346_abnormal_lacrimal_gland1.16361300
50MP0005025_abnormal_response_to1.15581724
51MP0008872_abnormal_physiological_respon1.14707974
52MP0001485_abnormal_pinna_reflex1.14011246
53MP0004084_abnormal_cardiac_muscle1.13463669
54MP0006276_abnormal_autonomic_nervous1.12981458
55MP0002653_abnormal_ependyma_morphology1.12394727
56MP0004036_abnormal_muscle_relaxation1.10752020
57MP0004043_abnormal_pH_regulation1.10282202
58MP0001845_abnormal_inflammatory_respons1.09121451
59MP0003075_altered_response_to1.07961317
60MP0002723_abnormal_immune_serum1.06435422
61MP0003828_pulmonary_edema1.03020813
62MP0004859_abnormal_synaptic_plasticity1.01558726
63MP0002452_abnormal_antigen_presenting1.01306004
64MP0008775_abnormal_heart_ventricle1.01116620
65MP0002184_abnormal_innervation1.01050110
66MP0004858_abnormal_nervous_system1.00612531
67MP0001800_abnormal_humoral_immune0.98687879
68MP0002972_abnormal_cardiac_muscle0.98053843
69MP0005023_abnormal_wound_healing0.97895310
70MP0009764_decreased_sensitivity_to0.97427160
71MP0003183_abnormal_peptide_metabolism0.97409716
72MP0005623_abnormal_meninges_morphology0.96722369
73MP0000685_abnormal_immune_system0.96574178
74MP0002419_abnormal_innate_immunity0.95944786
75MP0001790_abnormal_immune_system0.94105062
76MP0005387_immune_system_phenotype0.94105062
77MP0010329_abnormal_lipoprotein_level0.93846856
78MP0005646_abnormal_pituitary_gland0.93651583
79MP0002398_abnormal_bone_marrow0.90386396
80MP0005584_abnormal_enzyme/coenzyme_acti0.90115801
81MP0003718_maternal_effect0.89310937
82MP0005645_abnormal_hypothalamus_physiol0.88187363
83MP0000604_amyloidosis0.86449386
84MP0002733_abnormal_thermal_nociception0.86115802
85MP0003566_abnormal_cell_adhesion0.85000267
86MP0003635_abnormal_synaptic_transmissio0.84667358
87MP0002132_abnormal_respiratory_system0.81679218
88MP0000613_abnormal_salivary_gland0.80251895
89MP0008260_abnormal_autophagy0.79745597
90MP0002063_abnormal_learning/memory/cond0.79289930
91MP0004130_abnormal_muscle_cell0.79206136
92MP0002420_abnormal_adaptive_immunity0.78396472
93MP0005397_hematopoietic_system_phenotyp0.78189464
94MP0001545_abnormal_hematopoietic_system0.78189464
95MP0001819_abnormal_immune_cell0.78092499
96MP0004484_altered_response_of0.77826003
97MP0004947_skin_inflammation0.77084550
98MP0005620_abnormal_muscle_contractility0.76845096
99MP0000534_abnormal_ureter_morphology0.75802365
100MP0005165_increased_susceptibility_to0.75535280
101MP0000689_abnormal_spleen_morphology0.74864018
102MP0005266_abnormal_metabolism0.73785192
103MP0009333_abnormal_splenocyte_physiolog0.73603487
104MP0009642_abnormal_blood_homeostasis0.72519722
105MP0004270_analgesia0.72475046
106MP0002136_abnormal_kidney_physiology0.72430874
107MP0008873_increased_physiological_sensi0.72038106
108MP0002429_abnormal_blood_cell0.69458517
109MP0003303_peritoneal_inflammation0.68733044
110MP0003191_abnormal_cellular_cholesterol0.68621787
111MP0002877_abnormal_melanocyte_morpholog0.67775010
112MP0003866_abnormal_defecation0.67578314
113MP0005647_abnormal_sex_gland0.66473408
114MP0000716_abnormal_immune_system0.66054889
115MP0001664_abnormal_digestion0.64997302
116MP0002752_abnormal_somatic_nervous0.63991086
117MP0009745_abnormal_behavioral_response0.61701373
118MP0003690_abnormal_glial_cell0.61154396
119MP0002882_abnormal_neuron_morphology0.60743474
120MP0002896_abnormal_bone_mineralization0.60636531
121MP0005058_abnormal_lysosome_morphology0.60318362
122MP0000465_gastrointestinal_hemorrhage0.59721775
123MP0002734_abnormal_mechanical_nocicepti0.59702873
124MP0003633_abnormal_nervous_system0.59599262
125MP0003186_abnormal_redox_activity0.59242208
126MP0001486_abnormal_startle_reflex0.56250018
127MP0001299_abnormal_eye_distance/0.55603099
128MP0003942_abnormal_urinary_system0.55311168
129MP0005187_abnormal_penis_morphology0.54945810
130MP0002064_seizures0.52438274
131MP0006054_spinal_hemorrhage0.51601899
132MP0009780_abnormal_chondrocyte_physiolo0.50863238
133MP0004134_abnormal_chest_morphology0.50164733
134MP0002272_abnormal_nervous_system0.49812696
135MP0005367_renal/urinary_system_phenotyp0.49754704
136MP0000516_abnormal_urinary_system0.49754704
137MP0008961_abnormal_basal_metabolism0.49404897
138MP0004885_abnormal_endolymph0.49349200
139MP0008874_decreased_physiological_sensi0.49076387
140MP0005248_abnormal_Harderian_gland0.48815965
141MP0002557_abnormal_social/conspecific_i0.47712781
142MP0004085_abnormal_heartbeat0.47462633
143MP0002295_abnormal_pulmonary_circulatio0.46997353
144MP0005360_urolithiasis0.46969106
145MP0003705_abnormal_hypodermis_morpholog0.43825898
146MP0005410_abnormal_fertilization0.43800312
147MP0002572_abnormal_emotion/affect_behav0.43796064
148MP0000778_abnormal_nervous_system0.43335174
149MP0003634_abnormal_glial_cell0.43268012
150MP0001542_abnormal_bone_strength0.42084498
151MP0005167_abnormal_blood-brain_barrier0.40527662
152MP0005085_abnormal_gallbladder_physiolo0.40152128
153MP0005377_hearing/vestibular/ear_phenot0.40141145
154MP0003878_abnormal_ear_physiology0.40141145
155MP0001849_ear_inflammation0.39939392
156MP0009643_abnormal_urine_homeostasis0.39909437
157MP0004019_abnormal_vitamin_homeostasis0.39737631
158MP0000762_abnormal_tongue_morphology0.39305890
159MP0002837_dystrophic_cardiac_calcinosis0.38643777
160MP0002118_abnormal_lipid_homeostasis0.38197910
161MP0003631_nervous_system_phenotype0.38144035
162MP0004811_abnormal_neuron_physiology0.37858279
163MP0002152_abnormal_brain_morphology0.37544668
164MP0000609_abnormal_liver_physiology0.37352847
165MP0003300_gastrointestinal_ulcer0.33740473
166MP0003279_aneurysm0.32263703
167MP0005408_hypopigmentation0.32190295
168MP0003195_calcinosis0.31719361
169MP0002234_abnormal_pharynx_morphology0.31546405
170MP0001756_abnormal_urination0.31374404
171MP0005166_decreased_susceptibility_to0.30750928
172MP0008438_abnormal_cutaneous_collagen0.30602966
173MP0005508_abnormal_skeleton_morphology0.29872072
174MP0004185_abnormal_adipocyte_glucose0.29534875
175MP0005319_abnormal_enzyme/_coenzyme0.29413306
176MP0002332_abnormal_exercise_endurance0.29078912
177MP0002282_abnormal_trachea_morphology0.28862720
178MP0005275_abnormal_skin_tensile0.28381400
179MP0010630_abnormal_cardiac_muscle0.28295469
180MP0002133_abnormal_respiratory_system0.27846018

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)8.35694484
2Petechiae (HP:0000967)8.14034246
3Purpura (HP:0000979)8.03958757
4Menorrhagia (HP:0000132)7.70803182
5Increased mean platelet volume (HP:0011877)7.45914389
6Abnormal platelet volume (HP:0011876)6.99342558
7Decreased circulating renin level (HP:0003351)6.65627868
8Epistaxis (HP:0000421)5.78524520
9Atrioventricular block (HP:0001678)5.69406076
10Hyperlipoproteinemia (HP:0010980)5.65604764
11Ulnar bowing (HP:0003031)5.04473970
12Systemic lupus erythematosus (HP:0002725)4.90527068
13Prolonged QT interval (HP:0001657)4.84984083
14Gingival bleeding (HP:0000225)4.81025884
15Bifid scrotum (HP:0000048)4.59191008
16Syncope (HP:0001279)4.57894121
17Neurodegeneration (HP:0002180)4.48014199
18Palpitations (HP:0001962)4.38668337
19Hyperaldosteronism (HP:0000859)4.31598528
20Abnormal platelet function (HP:0011869)4.26322623
21Impaired platelet aggregation (HP:0003540)4.26322623
22Limb dystonia (HP:0002451)4.21241234
23Abnormality of macrophages (HP:0004311)4.14780739
24Bronchomalacia (HP:0002780)3.97139875
25Humeroradial synostosis (HP:0003041)3.92060351
26Synostosis involving the elbow (HP:0003938)3.92060351
27Abnormality of renin-angiotensin system (HP:0000847)3.89744869
28Heart block (HP:0012722)3.82949638
29Polydipsia (HP:0001959)3.73820887
30Abnormal drinking behavior (HP:0030082)3.73820887
31Abnormal atrioventricular conduction (HP:0005150)3.61359043
32Abnormal EKG (HP:0003115)3.50358708
33Abnormality of sodium homeostasis (HP:0010931)3.49053127
34Mitral stenosis (HP:0001718)3.28363661
35Primary atrial arrhythmia (HP:0001692)3.27750834
36Torticollis (HP:0000473)3.27017763
37Abnormality of dentin (HP:0010299)3.26123022
38Dysphonia (HP:0001618)3.18001596
39Abnormality of macular pigmentation (HP:0008002)3.15228430
40Paralysis (HP:0003470)3.13514918
41Supraventricular tachycardia (HP:0004755)3.12420549
42Abnormality of the prostate (HP:0008775)3.11822494
43Atrial fibrillation (HP:0005110)3.07902496
44Supraventricular arrhythmia (HP:0005115)3.05044071
45Bowed forearm bones (HP:0003956)3.02428058
46Bowing of the arm (HP:0006488)3.02428058
47Nausea (HP:0002018)3.01558729
48Hepatosplenomegaly (HP:0001433)2.96636590
49Thyroid-stimulating hormone excess (HP:0002925)2.95819710
50Stomatitis (HP:0010280)2.95495500
51Lip pit (HP:0100267)2.95476162
52Poikilocytosis (HP:0004447)2.95101667
53Craniofacial dystonia (HP:0012179)2.85253962
54Abnormal pupillary function (HP:0007686)2.84852621
55Vaginal fistula (HP:0004320)2.84696726
56Increased IgM level (HP:0003496)2.79384541
57Spontaneous hematomas (HP:0007420)2.77710557
58Hypokalemia (HP:0002900)2.76362397
59Joint swelling (HP:0001386)2.73928743
60Choanal stenosis (HP:0000452)2.71384870
61Atonic seizures (HP:0010819)2.68129258
62Hypercalciuria (HP:0002150)2.66353084
63Focal dystonia (HP:0004373)2.65933428
64Vacuolated lymphocytes (HP:0001922)2.58702139
65Conjunctival telangiectasia (HP:0000524)2.54356957
66Bony spicule pigmentary retinopathy (HP:0007737)2.54349517
67Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.52928972
68Glomerulonephritis (HP:0000099)2.52130269
69Femoral bowing (HP:0002980)2.46869377
70Labial hypoplasia (HP:0000066)2.45834711
71Adrenal overactivity (HP:0002717)2.45307183
72Elevated erythrocyte sedimentation rate (HP:0003565)2.43912276
73Abnormality of the heme biosynthetic pathway (HP:0010472)2.43601519
74Acanthocytosis (HP:0001927)2.41439586
75Polyuria (HP:0000103)2.41161526
76Cerebral inclusion bodies (HP:0100314)2.39476520
77Abnormal respiratory motile cilium morphology (HP:0005938)2.37141160
78Abnormal respiratory epithelium morphology (HP:0012253)2.37141160
79Vascular calcification (HP:0004934)2.36459077
80Arthropathy (HP:0003040)2.36199952
81Male infertility (HP:0003251)2.33832577
82Abnormality of lateral ventricle (HP:0030047)2.33782406
83Basal ganglia calcification (HP:0002135)2.33604996
84Bruising susceptibility (HP:0000978)2.32024409
85Bilateral sensorineural hearing impairment (HP:0008619)2.31189913
863-Methylglutaconic aciduria (HP:0003535)2.29273778
87Dynein arm defect of respiratory motile cilia (HP:0012255)2.28519770
88Absent/shortened dynein arms (HP:0200106)2.28519770
89Abnormal urine output (HP:0012590)2.28051082
90Abnormality of the vasculature of the conjunctiva (HP:0008054)2.27945425
91Abnormality of the common coagulation pathway (HP:0010990)2.27794517
92Autoimmune hemolytic anemia (HP:0001890)2.27784401
93Abnormality of iron homeostasis (HP:0011031)2.27106773
94Tinnitus (HP:0000360)2.26388387
95Complement deficiency (HP:0004431)2.23430063
96Turricephaly (HP:0000262)2.21564780
97Protrusio acetabuli (HP:0003179)2.20346324
98Joint hemorrhage (HP:0005261)2.19765649
99Encephalitis (HP:0002383)2.18527031
100Anosmia (HP:0000458)2.18482982
101Abnormality of potassium homeostasis (HP:0011042)2.16473054
102Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.15453221
103Amyloidosis (HP:0011034)2.12785451
104Abnormality of transition element cation homeostasis (HP:0011030)2.12108173
105Annular pancreas (HP:0001734)2.11647436
106Disproportionate short-trunk short stature (HP:0003521)2.11084511
107Neurofibrillary tangles (HP:0002185)2.11051434
108Pigmentary retinal degeneration (HP:0001146)2.10060491
109Abnormality of renal excretion (HP:0011036)2.08664940
110IgG deficiency (HP:0004315)2.07985003
111Loss of speech (HP:0002371)2.07720239
112Hypoplastic female external genitalia (HP:0012815)2.07089628
113Abnormal auditory evoked potentials (HP:0006958)2.06420281
114Hyperactive renin-angiotensin system (HP:0000841)2.06208647
115Renal tubular acidosis (HP:0001947)2.05430707
116Polycythemia (HP:0001901)2.05419948
117Recurrent gram-negative bacterial infections (HP:0005420)2.04943329
118Cardiovascular calcification (HP:0011915)2.04838757
119Deep venous thrombosis (HP:0002625)2.04823197
120Abnormal respiratory motile cilium physiology (HP:0012261)2.04044826
121Arnold-Chiari malformation (HP:0002308)2.01311633
122Increased serum ferritin (HP:0003281)2.01262559
123Arterial tortuosity (HP:0005116)2.00347746
124Hypothermia (HP:0002045)1.99044820
125IgM deficiency (HP:0002850)1.98214738
126Wormian bones (HP:0002645)1.96730595
127Chronic bronchitis (HP:0004469)1.95181614
128Pulmonary embolism (HP:0002204)1.93195405
129Erythema (HP:0010783)1.91247798
130Right ventricular cardiomyopathy (HP:0011663)1.89427950
131Back pain (HP:0003418)1.89228598
132Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.89189626
133Abnormality of monocarboxylic acid metabolism (HP:0010996)1.89141139
134Hypoproteinemia (HP:0003075)1.86514551
135Insomnia (HP:0100785)1.84843135
136Scrotal hypoplasia (HP:0000046)1.84085806
137Abnormal ciliary motility (HP:0012262)1.83912958
138Ketoacidosis (HP:0001993)1.82257045
139Abnormality of dental color (HP:0011073)1.81873873
140Increased cerebral lipofuscin (HP:0011813)1.81712525
141Vascular tortuosity (HP:0004948)1.81117313
142Tongue fasciculations (HP:0001308)1.80520000
143Broad metatarsal (HP:0001783)1.80242804
144Upper limb muscle weakness (HP:0003484)1.78421650
145Ventricular fibrillation (HP:0001663)1.78282695
146Acute necrotizing encephalopathy (HP:0006965)1.77281482
147Bronchiectasis (HP:0002110)1.73501696
148Generalized aminoaciduria (HP:0002909)1.73298521
149Dyschromatopsia (HP:0007641)1.72623474
150Chronic sinusitis (HP:0011109)1.72616704
151Acute encephalopathy (HP:0006846)1.72128247
152Recurrent sinusitis (HP:0011108)1.71397100
153Xanthomatosis (HP:0000991)1.71331030
154Bradycardia (HP:0001662)1.69649440
155Nephritis (HP:0000123)1.69390526
156Renal Fanconi syndrome (HP:0001994)1.69272548
157Mucosal telangiectasiae (HP:0100579)1.68878694
158Supranuclear gaze palsy (HP:0000605)1.67204781
159Arterial thrombosis (HP:0004420)1.64878624
160Constricted visual fields (HP:0001133)1.64762728
161Abnormality of methionine metabolism (HP:0010901)1.63278492
162Hyperglycinuria (HP:0003108)1.62639924
163Shallow orbits (HP:0000586)1.61230834
164Papillary thyroid carcinoma (HP:0002895)1.59591847
165Aplastic anemia (HP:0001915)1.59418980
166Abnormality of aspartate family amino acid metabolism (HP:0010899)1.59414448
167Progressive macrocephaly (HP:0004481)1.59150813
168Tarsal synostosis (HP:0008368)1.58842052
169Spastic diplegia (HP:0001264)1.58589934
170Depression (HP:0000716)1.58357844
171Increased density of long bones (HP:0006392)1.57900317
172Abnormality of aromatic amino acid family metabolism (HP:0004338)1.57224814
173Absence seizures (HP:0002121)1.57174884
174Infertility (HP:0000789)1.56969683
175Muscle fibrillation (HP:0010546)1.54823219
176Abnormal mitochondria in muscle tissue (HP:0008316)1.52870411
177Biliary tract neoplasm (HP:0100574)1.52737214
178Congenital, generalized hypertrichosis (HP:0004540)1.52488271
179Thoracolumbar scoliosis (HP:0002944)1.52028657
180Abnormality of glycine metabolism (HP:0010895)1.51848236
181Abnormality of serine family amino acid metabolism (HP:0010894)1.51848236
182Hyperglycinemia (HP:0002154)1.50684483
183Rhinitis (HP:0012384)1.50499642
184Cerebral aneurysm (HP:0004944)1.50222417
185Abnormality of male internal genitalia (HP:0000022)1.49876324
186Vertigo (HP:0002321)1.47943647
187Congenital sensorineural hearing impairment (HP:0008527)1.47706467
188Delayed CNS myelination (HP:0002188)1.47186070
189Abnormality of complement system (HP:0005339)1.47074405
190Xerostomia (HP:0000217)1.46788891
191Abnormal cartilage morphology (HP:0002763)1.46345906
192Generalized tonic-clonic seizures (HP:0002069)1.45827653

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.19386756
2MYLK4.14485370
3TYRO33.52423371
4TXK3.09648976
5PAK32.97013232
6RIPK42.94840871
7SIK22.81321898
8TAOK32.77188160
9CSF1R2.64694784
10CAMK2D2.60446046
11MAP3K122.58243884
12TRIB32.56836370
13RIPK12.53562822
14CAMK2B2.53408534
15TEC2.39856733
16BLK2.39259815
17SIK12.37394379
18DAPK22.14995222
19BTK2.13841866
20EIF2AK12.10347439
21ERBB32.04581490
22ADRBK22.02197487
23LATS12.00955855
24BMPR21.98836251
25PTK2B1.98186869
26GRK51.92725995
27CAMK2G1.90526988
28STK391.89853385
29HIPK21.87603058
30LMTK21.81160282
31PLK21.79929442
32SYK1.77862337
33MAPKAPK31.65736094
34CSNK1A1L1.61281077
35ZAP701.60611586
36FES1.56538114
37MAP3K21.48645074
38PIK3CG1.44735888
39PKN21.43041883
40FGR1.43035474
41ERN11.41832545
42GRK61.39525303
43TESK21.37542859
44EEF2K1.36911699
45DDR21.33115072
46PRKD31.33104285
47CSNK1G31.32918845
48LYN1.32879529
49PAK11.30593526
50FER1.29940654
51NTRK11.28223398
52CSNK1G21.24929470
53ALK1.23708049
54MAP3K71.21394468
55TGFBR21.19383490
56PRKCG1.13060384
57CSNK1G11.12607145
58EPHB11.11217188
59VRK21.08710450
60EPHA31.07000571
61PAK61.05512623
62KDR1.04787899
63NUAK11.03392686
64PRKG21.03043920
65MAP2K41.02669308
66MINK11.02586941
67TESK11.02148746
68MAP2K11.01757666
69KSR21.01607671
70IKBKB1.01353126
71FRK1.00361158
72HCK0.98515883
73NLK0.98268063
74STK30.96834888
75LRRK20.96168659
76VRK10.94548091
77PRKCH0.93928005
78GRK70.92036068
79MST1R0.90584974
80NEK10.88434227
81PRKD10.88214005
82MAP3K40.87661207
83TTN0.84965535
84TRIM280.81483099
85CAMK2A0.79365082
86TNK20.78981603
87RPS6KB20.78022602
88CAMKK10.77957045
89OXSR10.76966861
90PTK60.75560501
91ADRBK10.75172563
92ROCK20.74999486
93MAP3K50.74451884
94IGF1R0.71926749
95MAP4K20.69889784
96CDK50.69215392
97WNK40.68627137
98GRK10.68487655
99FGFR20.67121064
100TTK0.66851794
101CDK60.65778550
102SGK2230.65026253
103SGK4940.65026253
104PIK3CA0.64289366
105FYN0.64225143
106PHKG10.63582549
107PHKG20.63582549
108PDPK10.62916598
109PDGFRA0.62907370
110BCKDK0.62767067
111STK240.62605258
112TLK10.62032940
113STK160.60669424
114DAPK10.60012470
115PDK30.59840310
116PDK40.59840310
117TRPM70.59835689
118MAPK120.59146203
119MST40.58627910
120SCYL20.58363404
121CSK0.58286477
122SIK30.58080387
123NTRK30.56343409
124BMPR1B0.56273276
125PIM20.55254421
126MAP3K30.54597253
127DYRK1B0.54484992
128PKN10.53837131
129PDK20.53317042
130EPHB20.52050204
131RET0.51885586
132IKBKE0.51778975
133MAP3K100.51672092
134PLK30.51530657
135INSRR0.50490005
136LCK0.49871195
137ROCK10.49638696
138PINK10.49515358
139MARK10.49368109
140BMX0.47298703
141SGK30.47031283
142PRKCD0.46765190
143IRAK10.45985059
144ILK0.44918542
145WNK10.44406334
146ZAK0.44398982
147MATK0.42201909
148MAP2K20.41842244
149PRKACG0.41264364
150UHMK10.41213052
151ITK0.41127439
152PRKCZ0.40448672
153PAK20.40178335
154PDK10.40082354
155CDK80.39241259
156DAPK30.39127411
157ERBB20.39098348
158PRKCA0.38877350
159PRKG10.38715693
160TNIK0.37605322
161ACVR1B0.37175181
162ICK0.35908421
163PTK20.35652745
164MAPKAPK50.34595191
165CLK10.34120054
166IRAK40.33691188
167PRKCQ0.33333743
168CCNB10.31912966
169MAPK130.31648938
170PRKCE0.30742033
171OBSCN0.29415526
172JAK10.29226015
173PRKCB0.28287529
174PDGFRB0.28262767
175BRSK20.27950060

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047407.08816453
2Staphylococcus aureus infection_Homo sapiens_hsa051503.59845693
3Asthma_Homo sapiens_hsa053103.18767211
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.03968875
5Caffeine metabolism_Homo sapiens_hsa002323.03664560
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.98004229
7Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.89397673
8Glutathione metabolism_Homo sapiens_hsa004802.88931964
9Complement and coagulation cascades_Homo sapiens_hsa046102.85006440
10Allograft rejection_Homo sapiens_hsa053302.68870565
11Thyroid hormone synthesis_Homo sapiens_hsa049182.65833819
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.59765244
13SNARE interactions in vesicular transport_Homo sapiens_hsa041302.58786963
14Hematopoietic cell lineage_Homo sapiens_hsa046402.53464305
15Autoimmune thyroid disease_Homo sapiens_hsa053202.51349699
16Graft-versus-host disease_Homo sapiens_hsa053322.46730418
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.23652147
18Intestinal immune network for IgA production_Homo sapiens_hsa046722.20242796
19Sulfur metabolism_Homo sapiens_hsa009202.20220085
20Cyanoamino acid metabolism_Homo sapiens_hsa004602.12222129
21Systemic lupus erythematosus_Homo sapiens_hsa053222.10195462
22Butanoate metabolism_Homo sapiens_hsa006502.07350478
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.87955462
24Antigen processing and presentation_Homo sapiens_hsa046121.81302246
25Type I diabetes mellitus_Homo sapiens_hsa049401.79498031
26Histidine metabolism_Homo sapiens_hsa003401.77052892
27Arachidonic acid metabolism_Homo sapiens_hsa005901.73017872
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.72987990
29Fatty acid elongation_Homo sapiens_hsa000621.72198582
30Rheumatoid arthritis_Homo sapiens_hsa053231.68953964
31Vibrio cholerae infection_Homo sapiens_hsa051101.67766216
32Proteasome_Homo sapiens_hsa030501.67378920
33Bile secretion_Homo sapiens_hsa049761.66920329
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.65536499
35Salivary secretion_Homo sapiens_hsa049701.64905185
36beta-Alanine metabolism_Homo sapiens_hsa004101.63056910
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.55964495
38Chemical carcinogenesis_Homo sapiens_hsa052041.44289932
39Gastric acid secretion_Homo sapiens_hsa049711.43874435
40Morphine addiction_Homo sapiens_hsa050321.42499030
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.40980060
42Phagosome_Homo sapiens_hsa041451.35814001
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.32093937
44Malaria_Homo sapiens_hsa051441.29799083
45ECM-receptor interaction_Homo sapiens_hsa045121.25168916
46Viral myocarditis_Homo sapiens_hsa054161.24266774
47Nitrogen metabolism_Homo sapiens_hsa009101.23916914
48Circadian entrainment_Homo sapiens_hsa047131.21387563
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.18073213
50Primary immunodeficiency_Homo sapiens_hsa053401.18070284
51Insulin secretion_Homo sapiens_hsa049111.12263635
52Collecting duct acid secretion_Homo sapiens_hsa049661.12209008
53Oxidative phosphorylation_Homo sapiens_hsa001901.11718798
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07046733
55Chemokine signaling pathway_Homo sapiens_hsa040621.06185663
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.04288735
57GABAergic synapse_Homo sapiens_hsa047271.03156050
58Drug metabolism - other enzymes_Homo sapiens_hsa009831.03124812
59Dopaminergic synapse_Homo sapiens_hsa047281.00399035
60Parkinsons disease_Homo sapiens_hsa050120.99956434
61Synaptic vesicle cycle_Homo sapiens_hsa047210.98459428
62Fatty acid degradation_Homo sapiens_hsa000710.98185816
63Estrogen signaling pathway_Homo sapiens_hsa049150.97455007
64Pertussis_Homo sapiens_hsa051330.95414590
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93295763
66Retinol metabolism_Homo sapiens_hsa008300.93169569
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92261966
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91611245
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87397524
70Lysosome_Homo sapiens_hsa041420.86256172
71Pyruvate metabolism_Homo sapiens_hsa006200.85715299
72Alcoholism_Homo sapiens_hsa050340.84731081
73Endocytosis_Homo sapiens_hsa041440.83693756
74Starch and sucrose metabolism_Homo sapiens_hsa005000.82760373
75cAMP signaling pathway_Homo sapiens_hsa040240.82445651
76Sulfur relay system_Homo sapiens_hsa041220.81973987
77Tryptophan metabolism_Homo sapiens_hsa003800.81485709
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80731056
79Leishmaniasis_Homo sapiens_hsa051400.79786481
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79003526
81Galactose metabolism_Homo sapiens_hsa000520.78983614
82Shigellosis_Homo sapiens_hsa051310.78979665
83Propanoate metabolism_Homo sapiens_hsa006400.76068352
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75932737
85ABC transporters_Homo sapiens_hsa020100.75921527
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.75645562
87Ovarian steroidogenesis_Homo sapiens_hsa049130.73401412
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73223573
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.72820941
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72345879
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71648468
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.70214887
93Taste transduction_Homo sapiens_hsa047420.67885019
94Glutamatergic synapse_Homo sapiens_hsa047240.67881426
95Cholinergic synapse_Homo sapiens_hsa047250.67639901
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66815645
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.64638998
98Linoleic acid metabolism_Homo sapiens_hsa005910.64476957
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62285648
100Tuberculosis_Homo sapiens_hsa051520.60376514
101GnRH signaling pathway_Homo sapiens_hsa049120.59693486
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59307951
103Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57285258
104Arginine biosynthesis_Homo sapiens_hsa002200.56185054
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55454925
106Salmonella infection_Homo sapiens_hsa051320.54890414
107Renin secretion_Homo sapiens_hsa049240.54889154
108Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54842289
109Axon guidance_Homo sapiens_hsa043600.54503333
110Regulation of autophagy_Homo sapiens_hsa041400.53669696
111Dilated cardiomyopathy_Homo sapiens_hsa054140.52129005
112Renin-angiotensin system_Homo sapiens_hsa046140.52009325
113Glycerolipid metabolism_Homo sapiens_hsa005610.50295456
114Sphingolipid metabolism_Homo sapiens_hsa006000.50261681
115Melanogenesis_Homo sapiens_hsa049160.50020741
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49821669
1172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48884908
118Oxytocin signaling pathway_Homo sapiens_hsa049210.47344065
119Pancreatic secretion_Homo sapiens_hsa049720.47331645
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46946559
121Legionellosis_Homo sapiens_hsa051340.46946417
122Toxoplasmosis_Homo sapiens_hsa051450.46398455
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46265967
124Alzheimers disease_Homo sapiens_hsa050100.46171000
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46097359
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45719437
127Gap junction_Homo sapiens_hsa045400.45555969
128Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44455838
129Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43471521
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43236049
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42130142
132Amphetamine addiction_Homo sapiens_hsa050310.41577062
133Huntingtons disease_Homo sapiens_hsa050160.41148181
134Phenylalanine metabolism_Homo sapiens_hsa003600.40176416
135Calcium signaling pathway_Homo sapiens_hsa040200.39548013
136B cell receptor signaling pathway_Homo sapiens_hsa046620.38868056
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37883129
138T cell receptor signaling pathway_Homo sapiens_hsa046600.37785116
139Arginine and proline metabolism_Homo sapiens_hsa003300.37197776
140Vascular smooth muscle contraction_Homo sapiens_hsa042700.36340349
141Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36079169
142Cysteine and methionine metabolism_Homo sapiens_hsa002700.34883071
143PPAR signaling pathway_Homo sapiens_hsa033200.34827749
144Pentose phosphate pathway_Homo sapiens_hsa000300.34175215
145Peroxisome_Homo sapiens_hsa041460.33838645
146Fatty acid biosynthesis_Homo sapiens_hsa000610.32738182
147Influenza A_Homo sapiens_hsa051640.30868254
148Cocaine addiction_Homo sapiens_hsa050300.30768002
149Steroid biosynthesis_Homo sapiens_hsa001000.30393233
150Selenocompound metabolism_Homo sapiens_hsa004500.29802825
151Phototransduction_Homo sapiens_hsa047440.29573792
152Rap1 signaling pathway_Homo sapiens_hsa040150.29003548
153Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28950284
154Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26891461
155Adipocytokine signaling pathway_Homo sapiens_hsa049200.26399598
156Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26330052
157Amoebiasis_Homo sapiens_hsa051460.26066660
158Mineral absorption_Homo sapiens_hsa049780.26018437
159Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25772627
160Long-term potentiation_Homo sapiens_hsa047200.23087542
161Insulin resistance_Homo sapiens_hsa049310.22579894
162Platelet activation_Homo sapiens_hsa046110.22543503
163Fatty acid metabolism_Homo sapiens_hsa012120.22373772
164Serotonergic synapse_Homo sapiens_hsa047260.21383143
165Dorso-ventral axis formation_Homo sapiens_hsa043200.20593724
166Tyrosine metabolism_Homo sapiens_hsa003500.18784048
167Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17414315
168Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.16905788

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