ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein localization to cilium (GO:0061512)	8.09067172
2	one-carbon compound transport (GO:0019755)	5.81240880
3	positive regulation of digestive system process (GO:0060456)	5.70351174
4	tachykinin receptor signaling pathway (GO:0007217)	5.50899307
5	ethanol oxidation (GO:0006069)	5.45630579
6	antibacterial humoral response (GO:0019731)	5.24990927
7	regulation of cholesterol biosynthetic process (GO:0045540)	5.21474071
8	antimicrobial humoral response (GO:0019730)	4.86433004
9	cellular glucuronidation (GO:0052695)	4.67330091
10	glucuronate metabolic process (GO:0019585)	4.64282919
11	uronic acid metabolic process (GO:0006063)	4.64282919
12	activation of protein kinase A activity (GO:0034199)	4.45439998
13	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	4.42953623
14	regulation of sodium ion transmembrane transport (GO:1902305)	4.39520207
15	epoxygenase P450 pathway (GO:0019373)	4.29361307
16	ethanol metabolic process (GO:0006067)	4.21816270
17	lateral ventricle development (GO:0021670)	4.11600597
18	mating behavior (GO:0007617)	3.85209034
19	regulation of sodium ion transmembrane transporter activity (GO:2000649)	3.79412436
20	protein insertion into membrane (GO:0051205)	3.79176825
21	flavonoid metabolic process (GO:0009812)	3.76124987
22	gas transport (GO:0015669)	3.70332208
23	exogenous drug catabolic process (GO:0042738)	3.63136992
24	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.51565007
25	regulation of sodium ion transport (GO:0002028)	3.49696055
26	renal absorption (GO:0070293)	3.42465852
27	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	3.39990175
28	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.39723108
29	regulation of cholesterol metabolic process (GO:0090181)	3.32906114
30	negative regulation of astrocyte differentiation (GO:0048712)	3.30208555
31	cAMP biosynthetic process (GO:0006171)	3.30139578
32	water-soluble vitamin biosynthetic process (GO:0042364)	3.27608017
33	hormone catabolic process (GO:0042447)	3.26402628
34	regulation of heart rate by cardiac conduction (GO:0086091)	3.24232492
35	positive regulation of hormone biosynthetic process (GO:0046886)	3.23125356
36	cellular potassium ion homeostasis (GO:0030007)	3.16508677
37	alkaloid metabolic process (GO:0009820)	3.12575967
38	water transport (GO:0006833)	3.08977980
39	negative regulation of microtubule polymerization (GO:0031115)	3.05675393
40	drug catabolic process (GO:0042737)	3.04466992
41	sensory perception of smell (GO:0007608)	24.6736138
42	relaxation of cardiac muscle (GO:0055119)	2.99827777
43	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	2.99759030
44	membrane repolarization during action potential (GO:0086011)	2.96553907
45	omega-hydroxylase P450 pathway (GO:0097267)	2.91941124
46	cardiac conduction (GO:0061337)	2.89010572
47	layer formation in cerebral cortex (GO:0021819)	2.87507842
48	negative regulation of lipase activity (GO:0060192)	2.86700823
49	camera-type eye morphogenesis (GO:0048593)	2.86037492
50	ovulation cycle (GO:0042698)	2.83253954
51	toxin metabolic process (GO:0009404)	2.78261107
52	protein localization to endosome (GO:0036010)	2.76814793
53	response to vitamin A (GO:0033189)	2.76349427
54	potassium ion homeostasis (GO:0055075)	2.71356153
55	regulation of cardioblast proliferation (GO:0003264)	2.70593006
56	regulation of secondary heart field cardioblast proliferation (GO:0003266)	2.70593006
57	fluid transport (GO:0042044)	2.69668932
58	chemical homeostasis within a tissue (GO:0048875)	2.69604199
59	dopamine receptor signaling pathway (GO:0007212)	2.68908485
60	cellular copper ion homeostasis (GO:0006878)	2.68011168
61	regulation of steroid hormone biosynthetic process (GO:0090030)	2.67353262
62	negative regulation of amyloid precursor protein catabolic process (GO:1902992)	2.65590358
63	primary alcohol catabolic process (GO:0034310)	2.64769857
64	sulfur amino acid catabolic process (GO:0000098)	2.61731744
65	regulation of cilium movement (GO:0003352)	2.60644732
66	L-ascorbic acid metabolic process (GO:0019852)	2.58825052
67	positive regulation of steroid biosynthetic process (GO:0010893)	2.58753380
68	sodium ion export (GO:0071436)	2.58277830
69	negative regulation of sodium ion transport (GO:0010766)	2.56965397
70	calcium-mediated signaling using intracellular calcium source (GO:0035584)	2.51961548
71	ectoderm development (GO:0007398)	2.51934432
72	cell communication involved in cardiac conduction (GO:0086065)	2.49405182
73	response to caffeine (GO:0031000)	2.47369771
74	cellular response to glucagon stimulus (GO:0071377)	2.46259660
75	cilium morphogenesis (GO:0060271)	2.45938694
76	peptide biosynthetic process (GO:0043043)	2.44616216
77	endoplasmic reticulum calcium ion homeostasis (GO:0032469)	2.43622114
78	positive regulation of hormone metabolic process (GO:0032352)	2.40605545
79	atrial cardiac muscle cell action potential (GO:0086014)	2.38713541
80	axonal fasciculation (GO:0007413)	2.36430683
81	forebrain neuron development (GO:0021884)	2.35162015
82	glutamate secretion (GO:0014047)	2.32246021
83	establishment of apical/basal cell polarity (GO:0035089)	2.30783368
84	semaphorin-plexin signaling pathway (GO:0071526)	2.26735916
85	cAMP metabolic process (GO:0046058)	2.26217681
86	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.24631833
87	neuron cell-cell adhesion (GO:0007158)	2.21164476
88	negative regulation of immunoglobulin mediated immune response (GO:0002890)	2.20662880
89	negative regulation of B cell mediated immunity (GO:0002713)	2.20662880
90	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.20399118
91	behavioral response to cocaine (GO:0048148)	2.18419930
92	cellular response to electrical stimulus (GO:0071257)	2.17547357
93	response to follicle-stimulating hormone (GO:0032354)	2.17524924
94	innate immune response in mucosa (GO:0002227)	2.16831973
95	carnitine metabolic process (GO:0009437)	2.16614553
96	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.15976025
97	multicellular organismal water homeostasis (GO:0050891)	2.15433054
98	CDP-diacylglycerol biosynthetic process (GO:0016024)	2.14526235
99	chemosensory behavior (GO:0007635)	13.7009578
100	sensory perception of chemical stimulus (GO:0007606)	13.3222856

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.94342566
2	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.92346310
3	ZNF263_19887448_ChIP-Seq_K562_Human	2.72076578
4	ERG_21242973_ChIP-ChIP_JURKAT_Human	2.38157577
5	CLOCK_20551151_ChIP-Seq_293T_Human	2.07735149
6	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.97075118
7	* DROSHA_22980978_ChIP-Seq_HELA_Human	1.95702672
8	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.85916461
9	EZH2_22144423_ChIP-Seq_EOC_Human	1.85252978
10	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.77960456
11	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.77960456
12	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.77288877
13	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.76086636
14	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.69862553
15	KDM2B_26808549_Chip-Seq_K562_Human	1.66608230
16	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.62788396
17	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.61716084
18	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.57778548
19	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.57030852
20	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.56273168
21	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.54985796
22	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.50209280
23	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.49592862
24	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.46623379
25	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.45696694
26	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.45448340
27	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.42150092
28	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.40983450
29	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.40551362
30	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.37675780
31	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.37565118
32	AHR_22903824_ChIP-Seq_MCF-7_Human	1.35328624
33	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.35086998
34	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.34107958
35	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.33962590
36	TAF15_26573619_Chip-Seq_HEK293_Human	1.32740237
37	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.32156145
38	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.30510918
39	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.28355595
40	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.28196572
41	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.26282191
42	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.23519958
43	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.23373252
44	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.22239213
45	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.21044590
46	ERG_20517297_ChIP-Seq_VCAP_Human	1.20580117
47	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.20457555
48	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.20329899
49	GATA3_27048872_Chip-Seq_THYMUS_Human	1.19823250
50	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.19139563
51	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.18100605
52	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.17600842
53	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.15068112
54	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.12901267
55	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.10146228
56	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.10123844
57	LXR_22292898_ChIP-Seq_THP-1_Human	1.08855245
58	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.07853122
59	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.06047694
60	ISL1_27105846_Chip-Seq_CPCs_Mouse	1.05460512
61	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.05447264
62	MYC_19915707_ChIP-ChIP_AK7_Human	1.05327685
63	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	1.03850780
64	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.02763963
65	FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	1.02654845
66	ATF3_27146783_Chip-Seq_COLON_Human	1.02577830
67	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.00705404
68	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.00238564
69	ZFP281_27345836_Chip-Seq_ESCs_Mouse	0.99879148
70	KDM2B_26808549_Chip-Seq_JURKAT_Human	0.99633051
71	PPARA_22158963_ChIP-Seq_LIVER_Mouse	0.99168945
72	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	0.99152878
73	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.97419547
74	RACK7_27058665_Chip-Seq_MCF-7_Human	0.97418680
75	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.97330637
76	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.97099438
77	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	0.96518485
78	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.96250245
79	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.95820091
80	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.93902525
81	KLF5_25053715_ChIP-Seq_YYC3_Human	0.92898835
82	GATA1_22025678_ChIP-Seq_K562_Human	0.92559253
83	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.92398922
84	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.92269688
85	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.91858004
86	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.91204659
87	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.88883237
88	CTCF_27219007_Chip-Seq_Bcells_Human	0.88855325
89	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	0.88844579
90	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.88529938
91	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.87662779
92	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.87011769
93	KDM2B_26808549_Chip-Seq_DND41_Human	0.86601657
94	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.86566769
95	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.84136472
96	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.83459011
97	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	0.83342612
98	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.82741940
99	STAT1_20625510_ChIP-Seq_HELA_Human	0.81857236
100	DPY_21335234_ChIP-Seq_ESCs_Mouse	0.81114122

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005499_abnormal_olfactory_system	6.56145238
2	MP0005394_taste/olfaction_phenotype	6.56145238
3	MP0008875_abnormal_xenobiotic_pharmacok	5.43596784
4	MP0008789_abnormal_olfactory_epithelium	5.13747220
5	MP0003806_abnormal_nucleotide_metabolis	2.38382100
6	MP0010234_abnormal_vibrissa_follicle	2.02098366
7	MP0001984_abnormal_olfaction	13.7432056
8	MP0010030_abnormal_orbit_morphology	1.76762689
9	MP0002233_abnormal_nose_morphology	1.54844512
10	MP0002909_abnormal_adrenal_gland	1.40083247
11	MP0005365_abnormal_bile_salt	1.39437910
12	MP0002139_abnormal_hepatobiliary_system	1.34001193
13	MP0001485_abnormal_pinna_reflex	1.31823665
14	MP0001346_abnormal_lacrimal_gland	1.21549910
15	MP0005623_abnormal_meninges_morphology	1.16729149
16	MP0002653_abnormal_ependyma_morphology	1.13984039
17	MP0002822_catalepsy	1.11203561
18	MP0003329_amyloid_beta_deposits	1.09186337
19	MP0003075_altered_response_to	1.00171287
20	MP0002184_abnormal_innervation	0.98712625
21	MP0003566_abnormal_cell_adhesion	0.90781871
22	MP0004859_abnormal_synaptic_plasticity	0.89835044
23	MP0004858_abnormal_nervous_system	0.89751362
24	MP0000613_abnormal_salivary_gland	0.88376034
25	MP0010329_abnormal_lipoprotein_level	0.88344394
26	MP0004043_abnormal_pH_regulation	0.86408206
27	MP0000534_abnormal_ureter_morphology	0.83399460
28	MP0002896_abnormal_bone_mineralization	0.80249541
29	MP0000516_abnormal_urinary_system	0.78650233
30	MP0005367_renal/urinary_system_phenotyp	0.78650233
31	MP0000604_amyloidosis	0.78136428
32	MP0003635_abnormal_synaptic_transmissio	0.76262614
33	MP0005187_abnormal_penis_morphology	0.74743714
34	MP0002063_abnormal_learning/memory/cond	0.74722247
35	MP0005584_abnormal_enzyme/coenzyme_acti	0.73273833
36	MP0002877_abnormal_melanocyte_morpholog	0.72896546
37	MP0004270_analgesia	0.71368253
38	MP0001299_abnormal_eye_distance/	0.65523167
39	MP0005266_abnormal_metabolism	0.64982376
40	MP0003942_abnormal_urinary_system	0.63962239
41	MP0002752_abnormal_somatic_nervous	0.62556022
42	MP0005058_abnormal_lysosome_morphology	0.61862776
43	MP0009780_abnormal_chondrocyte_physiolo	0.61047777
44	MP0000465_gastrointestinal_hemorrhage	0.59054695
45	MP0006054_spinal_hemorrhage	0.58946517
46	MP0002882_abnormal_neuron_morphology	0.58770359
47	MP0003303_peritoneal_inflammation	0.58605338
48	MP0009745_abnormal_behavioral_response	0.55992216
49	MP0003633_abnormal_nervous_system	0.55322419
50	MP0002734_abnormal_mechanical_nocicepti	0.54024642
51	MP0003300_gastrointestinal_ulcer	0.52297526
52	MP0005248_abnormal_Harderian_gland	0.51965344
53	MP0001849_ear_inflammation	0.51236074
54	MP0004134_abnormal_chest_morphology	0.51018643
55	MP0004885_abnormal_endolymph	0.49209007
56	MP0003690_abnormal_glial_cell	0.48511171
57	MP0004085_abnormal_heartbeat	0.48421857
58	MP0001542_abnormal_bone_strength	0.47797709
59	MP0000778_abnormal_nervous_system	0.45886600
60	MP0008874_decreased_physiological_sensi	0.45382247
61	MP0002557_abnormal_social/conspecific_i	0.45124793
62	MP0001486_abnormal_startle_reflex	0.44911838
63	MP0000762_abnormal_tongue_morphology	0.43958930
64	MP0003283_abnormal_digestive_organ	0.43775844
65	MP0003195_calcinosis	0.43694611
66	MP0002064_seizures	0.43561001
67	MP0002272_abnormal_nervous_system	0.43285679
68	MP0002234_abnormal_pharynx_morphology	0.43014602
69	MP0005167_abnormal_blood-brain_barrier	0.42664108
70	MP0005508_abnormal_skeleton_morphology	0.42572020
71	MP0008961_abnormal_basal_metabolism	0.40471091
72	MP0003634_abnormal_glial_cell	0.40109994
73	MP0003705_abnormal_hypodermis_morpholog	0.40026415
74	MP0009643_abnormal_urine_homeostasis	0.37961968
75	MP0002837_dystrophic_cardiac_calcinosis	0.37755991
76	MP0003935_abnormal_craniofacial_develop	0.37432911
77	MP0002282_abnormal_trachea_morphology	0.37136860
78	MP0005410_abnormal_fertilization	0.37101222
79	MP0002152_abnormal_brain_morphology	0.36989355
80	MP0002092_abnormal_eye_morphology	0.36539418
81	MP0004811_abnormal_neuron_physiology	0.36428951
82	MP0002572_abnormal_emotion/affect_behav	0.36332734
83	MP0002295_abnormal_pulmonary_circulatio	0.36231392
84	MP0005360_urolithiasis	0.36134688
85	MP0003186_abnormal_redox_activity	0.34518162
86	MP0002118_abnormal_lipid_homeostasis	0.33790576
87	MP0005310_abnormal_salivary_gland	0.33339466
88	MP0004019_abnormal_vitamin_homeostasis	0.32950978
89	MP0003631_nervous_system_phenotype	0.32597977
90	MP0003252_abnormal_bile_duct	0.32436515
91	MP0000609_abnormal_liver_physiology	0.32167102
92	MP0003279_aneurysm	0.31977649
93	MP0000049_abnormal_middle_ear	0.31121959
94	MP0000631_abnormal_neuroendocrine_gland	0.30229328
95	MP0005377_hearing/vestibular/ear_phenot	0.30059637
96	MP0003878_abnormal_ear_physiology	0.30059637
97	MP0005645_abnormal_hypothalamus_physiol	0.29453934
98	MP0010630_abnormal_cardiac_muscle	0.29091473
99	MP0009384_cardiac_valve_regurgitation	0.28385744
100	MP0005319_abnormal_enzyme/_coenzyme	0.28090261

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Decreased circulating renin level (HP:0003351)	5.79945539
2	Ulnar bowing (HP:0003031)	5.37142912
3	Atrioventricular block (HP:0001678)	4.85850445
4	Abnormality of dentin (HP:0010299)	4.58445695
5	Bifid scrotum (HP:0000048)	4.50105775
6	Palpitations (HP:0001962)	4.35045519
7	Prolonged QT interval (HP:0001657)	4.30372991
8	Bronchomalacia (HP:0002780)	4.21283846
9	Humeroradial synostosis (HP:0003041)	4.16609832
10	Synostosis involving the elbow (HP:0003938)	4.16609832
11	Limb dystonia (HP:0002451)	4.12797632
12	Syncope (HP:0001279)	4.08981875
13	Bilateral sensorineural hearing impairment (HP:0008619)	3.77393796
14	Hyperaldosteronism (HP:0000859)	3.41813595
15	Abnormality of sodium homeostasis (HP:0010931)	3.38716596
16	Lip pit (HP:0100267)	3.21532162
17	Heart block (HP:0012722)	3.20458392
18	Bowing of the arm (HP:0006488)	3.17903057
19	Bowed forearm bones (HP:0003956)	3.17903057
20	Torticollis (HP:0000473)	3.15787842
21	Dysphonia (HP:0001618)	3.14133642
22	Abnormal EKG (HP:0003115)	3.11059093
23	Abnormality of renin-angiotensin system (HP:0000847)	3.09616083
24	Choanal stenosis (HP:0000452)	3.02743681
25	Abnormal atrioventricular conduction (HP:0005150)	3.01210391
26	Vaginal fistula (HP:0004320)	2.96198487
27	Atonic seizures (HP:0010819)	2.88339909
28	Poikilocytosis (HP:0004447)	2.82546547
29	Femoral bowing (HP:0002980)	2.82016908
30	Primary atrial arrhythmia (HP:0001692)	2.81763159
31	Labial hypoplasia (HP:0000066)	2.80567869
32	Craniofacial dystonia (HP:0012179)	2.77158180
33	Polydipsia (HP:0001959)	2.68938394
34	Abnormal drinking behavior (HP:0030082)	2.68938394
35	Abnormality of macular pigmentation (HP:0008002)	2.68406524
36	Atrial fibrillation (HP:0005110)	2.66353669
37	Supraventricular tachycardia (HP:0004755)	2.66014053
38	Supraventricular arrhythmia (HP:0005115)	2.60033443
39	Protrusio acetabuli (HP:0003179)	2.58580262
40	Focal dystonia (HP:0004373)	2.57375445
41	Hypoplastic female external genitalia (HP:0012815)	2.40537195
42	Turricephaly (HP:0000262)	2.34556990
43	Anosmia (HP:0000458)	2.33300093
44	Bony spicule pigmentary retinopathy (HP:0007737)	2.30210219
45	Hypokalemia (HP:0002900)	2.28971446
46	Abnormal respiratory motile cilium morphology (HP:0005938)	2.27305357
47	Abnormal respiratory epithelium morphology (HP:0012253)	2.27305357
48	Arterial tortuosity (HP:0005116)	2.23658425
49	Abnormal respiratory motile cilium physiology (HP:0012261)	2.16923011
50	Hypothermia (HP:0002045)	2.16437140
51	Wormian bones (HP:0002645)	2.15657781
52	Cerebral inclusion bodies (HP:0100314)	2.15368282
53	Arnold-Chiari malformation (HP:0002308)	2.15025507
54	Polycythemia (HP:0001901)	2.12561262
55	Abnormal ciliary motility (HP:0012262)	2.11090523
56	Broad metatarsal (HP:0001783)	2.10476648
57	Hypercalciuria (HP:0002150)	2.07829064
58	Vascular tortuosity (HP:0004948)	2.01546205
59	Renal tubular acidosis (HP:0001947)	1.99934945
60	Ketoacidosis (HP:0001993)	1.99821740
61	Adrenal overactivity (HP:0002717)	1.98698221
62	Scrotal hypoplasia (HP:0000046)	1.97702056
63	Right ventricular cardiomyopathy (HP:0011663)	1.94341020
64	Abnormality of potassium homeostasis (HP:0011042)	1.91211237
65	Annular pancreas (HP:0001734)	1.90137662
66	Cerebral aneurysm (HP:0004944)	1.88821900
67	Biliary tract neoplasm (HP:0100574)	1.85172483
68	Ventricular fibrillation (HP:0001663)	1.84631772
69	Bradycardia (HP:0001662)	1.84122915
70	Deep venous thrombosis (HP:0002625)	1.83833008
71	Chronic bronchitis (HP:0004469)	1.83653897
72	Insomnia (HP:0100785)	1.82307401
73	Tarsal synostosis (HP:0008368)	1.80178934
74	Amyloidosis (HP:0011034)	1.78254613
75	Abnormality of the dental pulp (HP:0006479)	1.77447650
76	Neurofibrillary tangles (HP:0002185)	1.77444649
77	Shallow orbits (HP:0000586)	1.75538598
78	Enlarged penis (HP:0000040)	1.72220491
79	Delayed CNS myelination (HP:0002188)	1.71323875
80	Polyuria (HP:0000103)	1.71196369
81	Thoracolumbar scoliosis (HP:0002944)	1.69108968
82	Bronchiectasis (HP:0002110)	1.67976773
83	Absence seizures (HP:0002121)	1.67689829
84	Morphological abnormality of the middle ear (HP:0008609)	1.66287247
85	Abnormal urine output (HP:0012590)	1.63132139
86	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.61372432
87	Generalized tonic-clonic seizures (HP:0002069)	1.60420545
88	Tinnitus (HP:0000360)	1.59127070
89	Depression (HP:0000716)	1.58492996
90	Xerostomia (HP:0000217)	1.58463091
91	Osteolytic defects of the phalanges of the hand (HP:0009771)	1.57421463
92	Osteolytic defects of the hand bones (HP:0009699)	1.57421463
93	Pulmonary embolism (HP:0002204)	1.57345993
94	Synostosis involving bones of the lower limbs (HP:0009138)	1.56902145
95	Synostosis involving bones of the feet (HP:0009140)	1.56902145
96	Supranuclear gaze palsy (HP:0000605)	1.56715830
97	Premature rupture of membranes (HP:0001788)	1.55161813
98	Abnormality of renal excretion (HP:0011036)	1.52805570
99	Spastic diplegia (HP:0001264)	1.52661728
100	Abnormality of the labia (HP:0000058)	1.52375630

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK15	3.98095430
2	TYRO3	3.38792587
3	PAK3	3.04901777
4	RIPK1	2.82865139
5	SIK1	2.51149565
6	CAMK2D	2.46489491
7	SIK2	2.46046884
8	TRIB3	2.38978548
9	CAMK2B	2.37735487
10	STK39	2.20521049
11	ERBB3	2.06149890
12	LATS1	2.05573007
13	HIPK2	2.02396717
14	DAPK2	2.00986903
15	LMTK2	1.90473088
16	CSNK1A1L	1.86543846
17	CAMK2G	1.73709364
18	MAP3K2	1.70795877
19	FRK	1.69655175
20	EEF2K	1.59729225
21	MAPKAPK3	1.56086499
22	TGFBR2	1.53303575
23	NEK1	1.50863789
24	DDR2	1.50387090
25	PKN2	1.48429968
26	FER	1.42480183
27	NTRK1	1.37952519
28	CSNK1G2	1.37593014
29	CSNK1G3	1.34494080
30	CSNK1G1	1.27578615
31	GRK6	1.26393645
32	MAP3K7	1.25718207
33	TESK1	1.25388425
34	PAK6	1.22792418
35	ALK	1.20872299
36	MAP2K4	1.07580542
37	SCYL2	1.07144919
38	ERN1	1.06330116
39	MAP3K4	1.05967444
40	KSR2	1.03691165
41	MAP2K1	1.03129325
42	MST1R	1.02224159
43	PRKCG	1.01952077
44	EPHB1	1.01816153
45	MINK1	0.95292936
46	FGFR2	0.94607189
47	OXSR1	0.93108123
48	TTK	0.88528912
49	PRKD1	0.86276857
50	CDK6	0.85956796
51	LRRK2	0.83286971
52	PRKG2	0.82861748
53	TTN	0.81421514
54	PDGFRA	0.79417306
55	PTK6	0.79122614
56	PRKCH	0.75612306
57	PRKD3	0.75009899
58	STK24	0.74193756
59	CAMKK1	0.73020731
60	WNK4	0.72744521
61	PDK4	0.71361979
62	PDK3	0.71361979
63	CAMK2A	0.70977868
64	ROCK2	0.69743886
65	RPS6KB2	0.67381471
66	CDK5	0.67090079
67	PDPK1	0.66268619
68	DYRK1B	0.64693705
69	MARK1	0.60585772
70	RET	0.58803478
71	FYN	0.58091660
72	TRPM7	0.57971023
73	MAP3K10	0.57309751
74	DAPK1	0.56213995
75	ITK	0.53691611
76	PHKG1	0.52191765
77	PHKG2	0.52191765
78	INSRR	0.49981680
79	CSK	0.49895301
80	BMX	0.49418706
81	LIMK1	0.49363902
82	PAK2	0.48259377
83	ERBB2	0.47723310
84	ICK	0.46616711
85	WNK1	0.46343940
86	NTRK3	0.44989795
87	PTK2	0.43564645
88	PDK2	0.41170778
89	MAPK10	0.39380097
90	BCKDK	0.39246771
91	UHMK1	0.39069906
92	CSNK1E	0.38918002
93	MAP3K9	0.38181928
94	MET	0.37751199
95	MAP2K2	0.37652248
96	CDC42BPA	0.37032529
97	ILK	0.36466602
98	PRKACG	0.36454831
99	MST4	0.36364237
100	EPHA3	0.35616021

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Olfactory transduction_Homo sapiens_hsa04740	6.78851652
2	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.14864242
3	Glutathione metabolism_Homo sapiens_hsa00480	3.12592223
4	Caffeine metabolism_Homo sapiens_hsa00232	3.11507712
5	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.96291920
6	Thyroid hormone synthesis_Homo sapiens_hsa04918	2.88536621
7	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	2.60775663
8	Butanoate metabolism_Homo sapiens_hsa00650	2.38389036
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.33760057
10	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.22433028
11	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.93357601
12	Sulfur metabolism_Homo sapiens_hsa00920	1.84437323
13	Salivary secretion_Homo sapiens_hsa04970	1.73356065
14	Vibrio cholerae infection_Homo sapiens_hsa05110	1.71910733
15	Bile secretion_Homo sapiens_hsa04976	1.68494365
16	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.68096775
17	Histidine metabolism_Homo sapiens_hsa00340	1.66617852
18	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.64781954
19	beta-Alanine metabolism_Homo sapiens_hsa00410	1.57352710
20	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.44789730
21	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.38055367
22	Gastric acid secretion_Homo sapiens_hsa04971	1.37986909
23	Morphine addiction_Homo sapiens_hsa05032	1.29018703
24	Chemical carcinogenesis_Homo sapiens_hsa05204	1.25659600
25	Nitrogen metabolism_Homo sapiens_hsa00910	1.22165214
26	Circadian entrainment_Homo sapiens_hsa04713	1.15609051
27	Insulin secretion_Homo sapiens_hsa04911	1.14583330
28	Collecting duct acid secretion_Homo sapiens_hsa04966	1.12435978
29	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.06105793
30	Dopaminergic synapse_Homo sapiens_hsa04728	1.04569049
31	GABAergic synapse_Homo sapiens_hsa04727	0.99815630
32	Estrogen signaling pathway_Homo sapiens_hsa04915	0.97814929
33	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.97071428
34	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.95985523
35	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.95816700
36	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.88813175
37	Retinol metabolism_Homo sapiens_hsa00830	0.86424648
38	Pyruvate metabolism_Homo sapiens_hsa00620	0.86025795
39	ABC transporters_Homo sapiens_hsa02010	0.84542881
40	Fatty acid degradation_Homo sapiens_hsa00071	0.83938857
41	cAMP signaling pathway_Homo sapiens_hsa04024	0.83249144
42	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.82286854
43	Propanoate metabolism_Homo sapiens_hsa00640	0.80392542
44	Tryptophan metabolism_Homo sapiens_hsa00380	0.80331945
45	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.77961892
46	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.76308619
47	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.73955370
48	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.70331365
49	Cholinergic synapse_Homo sapiens_hsa04725	0.67673984
50	Glutamatergic synapse_Homo sapiens_hsa04724	0.67514296
51	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.66565592
52	Taste transduction_Homo sapiens_hsa04742	0.65971396
53	GnRH signaling pathway_Homo sapiens_hsa04912	0.65778342
54	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.64261283
55	Renin secretion_Homo sapiens_hsa04924	0.59229934
56	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.58399143
57	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.58213369
58	Axon guidance_Homo sapiens_hsa04360	0.57284433
59	Melanogenesis_Homo sapiens_hsa04916	0.54937255
60	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.54433851
61	Arginine biosynthesis_Homo sapiens_hsa00220	0.53959569
62	Pancreatic secretion_Homo sapiens_hsa04972	0.51486384
63	Amphetamine addiction_Homo sapiens_hsa05031	0.49346447
64	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.48942955
65	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.48819037
66	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.48315948
67	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.48081661
68	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.47226905
69	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.46812957
70	Gap junction_Homo sapiens_hsa04540	0.45813139
71	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.44815041
72	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.44477120
73	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.43907299
74	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.39716100
75	Calcium signaling pathway_Homo sapiens_hsa04020	0.39318922
76	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.37865229
77	Sulfur relay system_Homo sapiens_hsa04122	0.37252612
78	Phenylalanine metabolism_Homo sapiens_hsa00360	0.36221504
79	Adherens junction_Homo sapiens_hsa04520	0.32761720
80	Arginine and proline metabolism_Homo sapiens_hsa00330	0.32010220
81	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.31207279
82	Rap1 signaling pathway_Homo sapiens_hsa04015	0.30985491
83	PPAR signaling pathway_Homo sapiens_hsa03320	0.29683556
84	Amoebiasis_Homo sapiens_hsa05146	0.29619937
85	Insulin resistance_Homo sapiens_hsa04931	0.29255787
86	Cocaine addiction_Homo sapiens_hsa05030	0.29128197
87	Long-term potentiation_Homo sapiens_hsa04720	0.27767623
88	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.26860756
89	Selenocompound metabolism_Homo sapiens_hsa00450	0.25939667
90	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.25863309
91	Type II diabetes mellitus_Homo sapiens_hsa04930	0.25450111
92	Phototransduction_Homo sapiens_hsa04744	0.25347203
93	Platelet activation_Homo sapiens_hsa04611	0.25338036
94	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.23502841
95	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.22945912
96	Mineral absorption_Homo sapiens_hsa04978	0.22182803
97	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.21286152
98	Fatty acid metabolism_Homo sapiens_hsa01212	0.18791924
99	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.17180844
100	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.16691533

BPIFB4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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