ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein localization to cilium (GO:0061512)	7.38505417
2	one-carbon compound transport (GO:0019755)	5.76153117
3	ethanol oxidation (GO:0006069)	5.30062940
4	regulation of cholesterol biosynthetic process (GO:0045540)	5.02407556
5	cellular glucuronidation (GO:0052695)	4.79661329
6	uronic acid metabolic process (GO:0006063)	4.70775762
7	glucuronate metabolic process (GO:0019585)	4.70775762
8	positive regulation of digestive system process (GO:0060456)	4.62398039
9	antibacterial humoral response (GO:0019731)	4.52460094
10	tachykinin receptor signaling pathway (GO:0007217)	4.40064206
11	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	4.30419794
12	activation of protein kinase A activity (GO:0034199)	4.23705142
13	mating behavior (GO:0007617)	4.21027301
14	epoxygenase P450 pathway (GO:0019373)	4.21011631
15	antimicrobial humoral response (GO:0019730)	4.17795212
16	ethanol metabolic process (GO:0006067)	4.10984212
17	lateral ventricle development (GO:0021670)	4.05176140
18	regulation of sodium ion transmembrane transport (GO:1902305)	3.98868682
19	flavonoid metabolic process (GO:0009812)	3.78839958
20	gas transport (GO:0015669)	3.65953693
21	regulation of sodium ion transmembrane transporter activity (GO:2000649)	3.56294040
22	exogenous drug catabolic process (GO:0042738)	3.49854009
23	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	3.38241171
24	cellular potassium ion homeostasis (GO:0030007)	3.33098554
25	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.32275321
26	renal absorption (GO:0070293)	3.28991660
27	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.27458424
28	positive regulation of hormone biosynthetic process (GO:0046886)	3.26895137
29	regulation of sodium ion transport (GO:0002028)	3.24220825
30	regulation of cholesterol metabolic process (GO:0090181)	3.23034559
31	hormone catabolic process (GO:0042447)	3.21470336
32	regulation of secondary heart field cardioblast proliferation (GO:0003266)	3.17280774
33	regulation of cardioblast proliferation (GO:0003264)	3.17280774
34	water-soluble vitamin biosynthetic process (GO:0042364)	3.14732322
35	negative regulation of astrocyte differentiation (GO:0048712)	3.12803526
36	regulation of heart rate by cardiac conduction (GO:0086091)	3.08665784
37	layer formation in cerebral cortex (GO:0021819)	3.08442206
38	alkaloid metabolic process (GO:0009820)	3.07790617
39	cAMP biosynthetic process (GO:0006171)	3.05210568
40	protein insertion into membrane (GO:0051205)	3.00192757
41	sensory perception of smell (GO:0007608)	23.6902964
42	water transport (GO:0006833)	2.99676561
43	relaxation of cardiac muscle (GO:0055119)	2.98646004
44	negative regulation of lipase activity (GO:0060192)	2.97505710
45	camera-type eye morphogenesis (GO:0048593)	2.96982035
46	membrane repolarization during action potential (GO:0086011)	2.95377842
47	drug catabolic process (GO:0042737)	2.92521553
48	response to vitamin A (GO:0033189)	2.85235868
49	chemical homeostasis within a tissue (GO:0048875)	2.81574601
50	omega-hydroxylase P450 pathway (GO:0097267)	2.80494254
51	ovulation cycle (GO:0042698)	2.80337516
52	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	2.79912377
53	negative regulation of microtubule polymerization (GO:0031115)	2.79881668
54	cardiac conduction (GO:0061337)	2.76030836
55	protein localization to endosome (GO:0036010)	2.73637532
56	sodium ion export (GO:0071436)	2.68009950
57	negative regulation of amyloid precursor protein catabolic process (GO:1902992)	2.65403535
58	regulation of steroid hormone biosynthetic process (GO:0090030)	2.64279664
59	potassium ion homeostasis (GO:0055075)	2.63440388
60	dopamine receptor signaling pathway (GO:0007212)	2.62980987
61	negative regulation of sodium ion transport (GO:0010766)	2.60998787
62	positive regulation of steroid biosynthetic process (GO:0010893)	2.60774266
63	fluid transport (GO:0042044)	2.60107322
64	axonal fasciculation (GO:0007413)	2.58297010
65	toxin metabolic process (GO:0009404)	2.57211301
66	L-ascorbic acid metabolic process (GO:0019852)	2.50521089
67	ectoderm development (GO:0007398)	2.48638102
68	cell communication involved in cardiac conduction (GO:0086065)	2.47301425
69	cellular copper ion homeostasis (GO:0006878)	2.45870654
70	primary alcohol catabolic process (GO:0034310)	2.43876152
71	calcium-mediated signaling using intracellular calcium source (GO:0035584)	2.42284007
72	positive regulation of hormone metabolic process (GO:0032352)	2.41238615
73	semaphorin-plexin signaling pathway (GO:0071526)	2.36748100
74	response to caffeine (GO:0031000)	2.34265393
75	sulfur amino acid catabolic process (GO:0000098)	2.33862590
76	neuron cell-cell adhesion (GO:0007158)	2.32842892
77	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.31467338
78	peptide biosynthetic process (GO:0043043)	2.30439311
79	glutamate secretion (GO:0014047)	2.30275844
80	cellular response to glucagon stimulus (GO:0071377)	2.26743161
81	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.24325455
82	behavioral response to cocaine (GO:0048148)	2.22715162
83	endoplasmic reticulum calcium ion homeostasis (GO:0032469)	2.22095102
84	cilium morphogenesis (GO:0060271)	2.20469546
85	cytoskeletal anchoring at plasma membrane (GO:0007016)	2.18722566
86	membrane repolarization (GO:0086009)	2.17275070
87	carnitine metabolic process (GO:0009437)	2.16124101
88	short-chain fatty acid metabolic process (GO:0046459)	2.14840179
89	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.14158532
90	atrial cardiac muscle cell action potential (GO:0086014)	2.13864460
91	CDP-diacylglycerol biosynthetic process (GO:0016024)	2.13411095
92	cellular response to epidermal growth factor stimulus (GO:0071364)	2.12300777
93	positive regulation of steroid metabolic process (GO:0045940)	2.10530545
94	regulation of cilium movement (GO:0003352)	2.10461732
95	neuron recognition (GO:0008038)	2.10034273
96	cAMP metabolic process (GO:0046058)	2.09084156
97	establishment of apical/basal cell polarity (GO:0035089)	2.07581920
98	forebrain neuron development (GO:0021884)	2.07563184
99	chemosensory behavior (GO:0007635)	14.6077588
100	sensory perception of chemical stimulus (GO:0007606)	12.7187216

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.56404086
2	DROSHA_22980978_ChIP-Seq_HELA_Human	3.03585934
3	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.95746479
4	ZNF263_19887448_ChIP-Seq_K562_Human	2.74609678
5	ERG_21242973_ChIP-ChIP_JURKAT_Human	2.32071837
6	CLOCK_20551151_ChIP-Seq_293T_Human	2.11714760
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.08266022
8	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.93840208
9	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.82670864
10	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.82670864
11	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.81039005
12	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.72534024
13	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.68462804
14	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.66937714
15	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.57981373
16	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.57967291
17	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.55000150
18	KDM2B_26808549_Chip-Seq_K562_Human	1.53749559
19	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.52964920
20	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.51974546
21	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.51719822
22	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.50580180
23	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.50280177
24	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.48702249
25	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.46160424
26	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.42977202
27	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.42874431
28	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.41001822
29	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.40170193
30	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.40131556
31	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.39110761
32	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.38602147
33	AHR_22903824_ChIP-Seq_MCF-7_Human	1.38588520
34	TAF15_26573619_Chip-Seq_HEK293_Human	1.37211007
35	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.35588541
36	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.33288862
37	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.31025334
38	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.29186801
39	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.27976836
40	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.26961871
41	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.22922978
42	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.19885665
43	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.19713002
44	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.19149780
45	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.17663912
46	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.15568540
47	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.14681510
48	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.14634634
49	GATA3_27048872_Chip-Seq_THYMUS_Human	1.13817728
50	ERG_20517297_ChIP-Seq_VCAP_Human	1.13756806
51	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.13187493
52	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.12384666
53	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.12138331
54	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.11512307
55	ISL1_27105846_Chip-Seq_CPCs_Mouse	1.10823025
56	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.08492970
57	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	1.05983296
58	FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	1.05415234
59	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.05283585
60	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.05018616
61	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.04634523
62	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.04572490
63	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.02161782
64	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.99651057
65	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.99074425
66	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.98899326
67	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97941091
68	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.96984729
69	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95880073
70	KDM2B_26808549_Chip-Seq_JURKAT_Human	0.95216578
71	PPARA_22158963_ChIP-Seq_LIVER_Mouse	0.95176880
72	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.94769716
73	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.94243296
74	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.94199733
75	ZFP281_27345836_Chip-Seq_ESCs_Mouse	0.94018636
76	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.93866351
77	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	0.93292082
78	MYC_19915707_ChIP-ChIP_AK7_Human	0.91523174
79	ATF3_27146783_Chip-Seq_COLON_Human	0.90854581
80	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.90330628
81	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.88895885
82	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.88574607
83	KLF5_25053715_ChIP-Seq_YYC3_Human	0.88286643
84	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.87233204
85	LXR_22292898_ChIP-Seq_THP-1_Human	0.87127525
86	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.87007689
87	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.86714151
88	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.86062086
89	RACK7_27058665_Chip-Seq_MCF-7_Human	0.85617259
90	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	0.84410406
91	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	0.84373624
92	GATA1_22025678_ChIP-Seq_K562_Human	0.83648924
93	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.82889954
94	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.82722159
95	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.82631043
96	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.81969131
97	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.81911651
98	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.81565853
99	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.81126467
100	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.79342089

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005394_taste/olfaction_phenotype	6.53988989
2	MP0005499_abnormal_olfactory_system	6.53988989
3	MP0008875_abnormal_xenobiotic_pharmacok	5.56578081
4	MP0008789_abnormal_olfactory_epithelium	4.92021468
5	MP0010234_abnormal_vibrissa_follicle	2.25108243
6	MP0003806_abnormal_nucleotide_metabolis	2.17833630
7	MP0001984_abnormal_olfaction	13.2780391
8	MP0010030_abnormal_orbit_morphology	1.88391858
9	MP0002233_abnormal_nose_morphology	1.54622534
10	MP0002139_abnormal_hepatobiliary_system	1.46941545
11	MP0001485_abnormal_pinna_reflex	1.44672936
12	MP0005365_abnormal_bile_salt	1.44109947
13	MP0001346_abnormal_lacrimal_gland	1.42656680
14	MP0002909_abnormal_adrenal_gland	1.35673166
15	MP0005623_abnormal_meninges_morphology	1.25097493
16	MP0003329_amyloid_beta_deposits	1.14984210
17	MP0005187_abnormal_penis_morphology	1.13693079
18	MP0002822_catalepsy	1.02560282
19	MP0003075_altered_response_to	1.00389071
20	MP0004859_abnormal_synaptic_plasticity	0.95897483
21	MP0002184_abnormal_innervation	0.95446033
22	MP0004858_abnormal_nervous_system	0.94274924
23	MP0004043_abnormal_pH_regulation	0.93861951
24	MP0002653_abnormal_ependyma_morphology	0.93054277
25	MP0003566_abnormal_cell_adhesion	0.92564089
26	MP0010329_abnormal_lipoprotein_level	0.90091612
27	MP0000613_abnormal_salivary_gland	0.89574100
28	MP0000534_abnormal_ureter_morphology	0.89547939
29	MP0002896_abnormal_bone_mineralization	0.87792792
30	MP0009780_abnormal_chondrocyte_physiolo	0.87336618
31	MP0000604_amyloidosis	0.82887996
32	MP0003635_abnormal_synaptic_transmissio	0.79954443
33	MP0002063_abnormal_learning/memory/cond	0.79798369
34	MP0001299_abnormal_eye_distance/	0.79213058
35	MP0002877_abnormal_melanocyte_morpholog	0.78341294
36	MP0000516_abnormal_urinary_system	0.74603864
37	MP0005367_renal/urinary_system_phenotyp	0.74603864
38	MP0004270_analgesia	0.71083434
39	MP0003690_abnormal_glial_cell	0.69748864
40	MP0003300_gastrointestinal_ulcer	0.69478834
41	MP0003942_abnormal_urinary_system	0.67434876
42	MP0005058_abnormal_lysosome_morphology	0.64703569
43	MP0005584_abnormal_enzyme/coenzyme_acti	0.64679735
44	MP0002752_abnormal_somatic_nervous	0.62266639
45	MP0006054_spinal_hemorrhage	0.61402246
46	MP0003633_abnormal_nervous_system	0.61206930
47	MP0002882_abnormal_neuron_morphology	0.60848571
48	MP0009745_abnormal_behavioral_response	0.58444548
49	MP0001849_ear_inflammation	0.56075421
50	MP0000465_gastrointestinal_hemorrhage	0.55811841
51	MP0003303_peritoneal_inflammation	0.55459470
52	MP0003705_abnormal_hypodermis_morpholog	0.54511001
53	MP0004885_abnormal_endolymph	0.54100578
54	MP0000778_abnormal_nervous_system	0.52254746
55	MP0005266_abnormal_metabolism	0.51013163
56	MP0004085_abnormal_heartbeat	0.50217685
57	MP0000631_abnormal_neuroendocrine_gland	0.50186551
58	MP0001486_abnormal_startle_reflex	0.50111768
59	MP0004134_abnormal_chest_morphology	0.50013453
60	MP0002234_abnormal_pharynx_morphology	0.49674996
61	MP0002734_abnormal_mechanical_nocicepti	0.49530619
62	MP0002557_abnormal_social/conspecific_i	0.48036000
63	MP0002064_seizures	0.47303597
64	MP0008961_abnormal_basal_metabolism	0.47192757
65	MP0005167_abnormal_blood-brain_barrier	0.46693684
66	MP0005248_abnormal_Harderian_gland	0.46579857
67	MP0003634_abnormal_glial_cell	0.46458686
68	MP0003935_abnormal_craniofacial_develop	0.45958003
69	MP0008874_decreased_physiological_sensi	0.45933929
70	MP0004185_abnormal_adipocyte_glucose	0.43146889
71	MP0002272_abnormal_nervous_system	0.43070843
72	MP0005310_abnormal_salivary_gland	0.42771996
73	MP0000762_abnormal_tongue_morphology	0.42212599
74	MP0002009_preneoplasia	0.41990164
75	MP0001542_abnormal_bone_strength	0.41035415
76	MP0005508_abnormal_skeleton_morphology	0.40498135
77	MP0002837_dystrophic_cardiac_calcinosis	0.39517204
78	MP0002152_abnormal_brain_morphology	0.38815806
79	MP0003252_abnormal_bile_duct	0.38744157
80	MP0002092_abnormal_eye_morphology	0.38030832
81	MP0002090_abnormal_vision	0.37955955
82	MP0004811_abnormal_neuron_physiology	0.37923996
83	MP0003283_abnormal_digestive_organ	0.37759466
84	MP0003091_abnormal_cell_migration	0.37625421
85	MP0003279_aneurysm	0.37505178
86	MP0005551_abnormal_eye_electrophysiolog	0.37050430
87	MP0005360_urolithiasis	0.36581740
88	MP0010678_abnormal_skin_adnexa	0.36046376
89	MP0003631_nervous_system_phenotype	0.35791598
90	MP0002282_abnormal_trachea_morphology	0.35550173
91	MP0002572_abnormal_emotion/affect_behav	0.35458542
92	MP0002118_abnormal_lipid_homeostasis	0.35022795
93	MP0002067_abnormal_sensory_capabilities	0.34908975
94	MP0000609_abnormal_liver_physiology	0.34005925
95	MP0001501_abnormal_sleep_pattern	0.33750870
96	MP0009643_abnormal_urine_homeostasis	0.33643745
97	MP0003195_calcinosis	0.33044486
98	MP0000049_abnormal_middle_ear	0.32809383
99	MP0009384_cardiac_valve_regurgitation	0.32784340
100	MP0000681_abnormal_thyroid_gland	0.32661237

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Ulnar bowing (HP:0003031)	5.26167087
2	Decreased circulating renin level (HP:0003351)	4.88835114
3	Abnormality of dentin (HP:0010299)	4.63637840
4	Bifid scrotum (HP:0000048)	4.32793000
5	Bronchomalacia (HP:0002780)	4.28116748
6	Atrioventricular block (HP:0001678)	4.27626125
7	Synostosis involving the elbow (HP:0003938)	4.18744734
8	Humeroradial synostosis (HP:0003041)	4.18744734
9	Palpitations (HP:0001962)	4.01124791
10	Bilateral sensorineural hearing impairment (HP:0008619)	4.00660654
11	Limb dystonia (HP:0002451)	3.84535612
12	Prolonged QT interval (HP:0001657)	3.71208083
13	Syncope (HP:0001279)	3.64912797
14	Lip pit (HP:0100267)	3.60573319
15	Bowing of the arm (HP:0006488)	3.13046235
16	Bowed forearm bones (HP:0003956)	3.13046235
17	Abnormality of sodium homeostasis (HP:0010931)	3.03914493
18	Dysphonia (HP:0001618)	2.97815511
19	Torticollis (HP:0000473)	2.96790914
20	Femoral bowing (HP:0002980)	2.92324507
21	Choanal stenosis (HP:0000452)	2.90633143
22	Vaginal fistula (HP:0004320)	2.87898277
23	Atonic seizures (HP:0010819)	2.78805466
24	Abnormal EKG (HP:0003115)	2.77857373
25	Heart block (HP:0012722)	2.77568311
26	Protrusio acetabuli (HP:0003179)	2.77516956
27	Hyperaldosteronism (HP:0000859)	2.72402390
28	Labial hypoplasia (HP:0000066)	2.72026267
29	Poikilocytosis (HP:0004447)	2.64650778
30	Abnormality of renin-angiotensin system (HP:0000847)	2.63301351
31	Abnormal atrioventricular conduction (HP:0005150)	2.59805247
32	Craniofacial dystonia (HP:0012179)	2.56762503
33	Primary atrial arrhythmia (HP:0001692)	2.53684412
34	Arterial tortuosity (HP:0005116)	2.51619823
35	Atrial fibrillation (HP:0005110)	2.40855837
36	Focal dystonia (HP:0004373)	2.37979250
37	Supraventricular tachycardia (HP:0004755)	2.37260289
38	Turricephaly (HP:0000262)	2.36114301
39	Abnormality of macular pigmentation (HP:0008002)	2.34279423
40	Supraventricular arrhythmia (HP:0005115)	2.32260028
41	Hypoplastic female external genitalia (HP:0012815)	2.31589851
42	Vascular tortuosity (HP:0004948)	2.26268384
43	Arnold-Chiari malformation (HP:0002308)	2.19339420
44	Cerebral inclusion bodies (HP:0100314)	2.17875322
45	Broad metatarsal (HP:0001783)	2.16519198
46	Anosmia (HP:0000458)	2.15672893
47	Bony spicule pigmentary retinopathy (HP:0007737)	2.14663826
48	Wormian bones (HP:0002645)	2.14662506
49	Polydipsia (HP:0001959)	2.13634099
50	Abnormal drinking behavior (HP:0030082)	2.13634099
51	Polycythemia (HP:0001901)	2.13214358
52	Right ventricular cardiomyopathy (HP:0011663)	2.00187625
53	Cerebral aneurysm (HP:0004944)	1.99499939
54	Hypothermia (HP:0002045)	1.99463006
55	Ketoacidosis (HP:0001993)	1.95708312
56	Hypokalemia (HP:0002900)	1.94362484
57	Scrotal hypoplasia (HP:0000046)	1.91563361
58	Abnormal ciliary motility (HP:0012262)	1.90886858
59	Insomnia (HP:0100785)	1.90268566
60	Abnormal respiratory motile cilium morphology (HP:0005938)	1.89081442
61	Abnormal respiratory epithelium morphology (HP:0012253)	1.89081442
62	Abnormal respiratory motile cilium physiology (HP:0012261)	1.88411936
63	Deep venous thrombosis (HP:0002625)	1.88379763
64	Tarsal synostosis (HP:0008368)	1.87500844
65	Shallow orbits (HP:0000586)	1.85942379
66	Bradycardia (HP:0001662)	1.81734116
67	Hypercalciuria (HP:0002150)	1.81104329
68	Biliary tract neoplasm (HP:0100574)	1.80561302
69	Abnormality of the dental pulp (HP:0006479)	1.80162522
70	Renal tubular acidosis (HP:0001947)	1.79134397
71	Osteolytic defects of the phalanges of the hand (HP:0009771)	1.78570910
72	Osteolytic defects of the hand bones (HP:0009699)	1.78570910
73	Absence seizures (HP:0002121)	1.77864533
74	Neurofibrillary tangles (HP:0002185)	1.77663965
75	Annular pancreas (HP:0001734)	1.77599394
76	Morphological abnormality of the middle ear (HP:0008609)	1.76810313
77	Insidious onset (HP:0003587)	1.76232628
78	Termporal pattern (HP:0011008)	1.76232628
79	Depression (HP:0000716)	1.75087875
80	Ventricular fibrillation (HP:0001663)	1.74440207
81	Enlarged penis (HP:0000040)	1.73888551
82	Adrenal overactivity (HP:0002717)	1.73331512
83	Tinnitus (HP:0000360)	1.72928209
84	Generalized tonic-clonic seizures (HP:0002069)	1.72153359
85	Abnormality of potassium homeostasis (HP:0011042)	1.71539695
86	Subcapsular cataract (HP:0000523)	1.68341033
87	Abnormality of the frontal sinuses (HP:0002687)	1.67506291
88	Amyloidosis (HP:0011034)	1.67172230
89	Preauricular pit (HP:0004467)	1.65516727
90	Periauricular skin pits (HP:0100277)	1.65516727
91	Mitral valve prolapse (HP:0001634)	1.65186861
92	Aortic dissection (HP:0002647)	1.64225610
93	Aortic aneurysm (HP:0004942)	1.63817624
94	Thoracolumbar scoliosis (HP:0002944)	1.63480424
95	Synostosis involving bones of the lower limbs (HP:0009138)	1.63468076
96	Synostosis involving bones of the feet (HP:0009140)	1.63468076
97	Resting tremor (HP:0002322)	1.62994335
98	Premature rupture of membranes (HP:0001788)	1.62257070
99	Ankle contracture (HP:0006466)	1.61703907
100	Delayed CNS myelination (HP:0002188)	1.58829794

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TYRO3	3.20831343
2	MAPK15	3.13539319
3	RIPK1	3.09452439
4	PAK3	2.94044775
5	SIK1	2.48562924
6	STK39	2.46200601
7	TRIB3	2.44137927
8	CAMK2D	2.24446002
9	SIK2	2.12884388
10	CAMK2B	2.10951707
11	ERBB3	2.07496506
12	HIPK2	2.05219298
13	LATS1	1.98845947
14	LMTK2	1.91869734
15	FRK	1.90496320
16	DAPK2	1.88530066
17	MAP3K2	1.86355878
18	CSNK1A1L	1.79694549
19	NEK1	1.69818563
20	PKN2	1.67423861
21	TGFBR2	1.67405394
22	DDR2	1.53477451
23	CAMK2G	1.49473825
24	EEF2K	1.45781247
25	FGFR2	1.40268313
26	SCYL2	1.37588986
27	FER	1.35295737
28	MAP3K7	1.33722078
29	CSNK1G2	1.33265274
30	PAK6	1.31920332
31	NTRK1	1.28636814
32	CSNK1G1	1.23947063
33	CSNK1G3	1.20355978
34	MAP2K4	1.17367377
35	GRK6	1.16825027
36	CDK6	1.15063787
37	TESK1	1.13067508
38	MAP3K4	1.12418570
39	OXSR1	1.07795086
40	ALK	1.06967646
41	MST1R	1.03631967
42	MAPKAPK3	1.03545762
43	KSR2	1.02676422
44	MAP2K1	1.00949578
45	MINK1	1.00797763
46	TRPM7	0.97801520
47	EPHB1	0.97609261
48	TTN	0.92203056
49	PRKCG	0.88935734
50	PDGFRA	0.87658706
51	ERN1	0.86643999
52	PRKD1	0.84226180
53	TTK	0.78563327
54	DYRK1B	0.77323396
55	WNK4	0.77292335
56	PTK6	0.77180936
57	PRKCH	0.76654146
58	PRKG2	0.74983503
59	PDK3	0.74197035
60	PDK4	0.74197035
61	CAMKK1	0.73139856
62	RET	0.72448114
63	LRRK2	0.72286032
64	PDPK1	0.69142497
65	CDK5	0.67987089
66	ROCK2	0.67048309
67	CAMK2A	0.66973978
68	INSRR	0.64633159
69	STK24	0.59953802
70	PRKD3	0.58893527
71	MARK1	0.58217728
72	PHKG2	0.58081481
73	PHKG1	0.58081481
74	FYN	0.57648281
75	UHMK1	0.57296555
76	ITK	0.57123673
77	WNK1	0.56708949
78	NTRK3	0.55415987
79	BMX	0.52590249
80	PAK2	0.51350691
81	ERBB2	0.51193560
82	CSK	0.50795529
83	FGFR3	0.49876435
84	MAP3K9	0.49858261
85	LIMK1	0.47199938
86	CDC42BPA	0.43865216
87	ICK	0.42739450
88	RPS6KB2	0.42714927
89	MAPK10	0.42317034
90	FGFR1	0.40687118
91	STK3	0.40619357
92	DAPK1	0.40056815
93	PTK2	0.39245221
94	CSNK1E	0.38541216
95	MET	0.35966571
96	PDK2	0.34682733
97	BCR	0.33826656
98	MAP3K10	0.33720673
99	TAOK1	0.32473488
100	PRKACG	0.32438075

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Olfactory transduction_Homo sapiens_hsa04740	6.16587234
2	Glutathione metabolism_Homo sapiens_hsa00480	3.13047944
3	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.12128277
4	Caffeine metabolism_Homo sapiens_hsa00232	3.00548697
5	Thyroid hormone synthesis_Homo sapiens_hsa04918	2.98222128
6	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.90433383
7	Butanoate metabolism_Homo sapiens_hsa00650	2.62504612
8	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	2.47038989
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.32327028
10	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.17449063
11	Arachidonic acid metabolism_Homo sapiens_hsa00590	2.02358778
12	Salivary secretion_Homo sapiens_hsa04970	1.77909967
13	Bile secretion_Homo sapiens_hsa04976	1.67869439
14	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.62687437
15	Sulfur metabolism_Homo sapiens_hsa00920	1.61327322
16	Vibrio cholerae infection_Homo sapiens_hsa05110	1.54387886
17	Histidine metabolism_Homo sapiens_hsa00340	1.51514761
18	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.50723009
19	beta-Alanine metabolism_Homo sapiens_hsa00410	1.50192944
20	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.47037947
21	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.37919720
22	Gastric acid secretion_Homo sapiens_hsa04971	1.35617294
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.27004212
24	Morphine addiction_Homo sapiens_hsa05032	1.20807299
25	Chemical carcinogenesis_Homo sapiens_hsa05204	1.19655675
26	Circadian entrainment_Homo sapiens_hsa04713	1.16283640
27	Insulin secretion_Homo sapiens_hsa04911	1.05253457
28	Collecting duct acid secretion_Homo sapiens_hsa04966	1.05221823
29	Dopaminergic synapse_Homo sapiens_hsa04728	1.03433941
30	GABAergic synapse_Homo sapiens_hsa04727	0.98914311
31	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.97685718
32	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.95150038
33	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.92946602
34	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.92765889
35	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.91824707
36	Pyruvate metabolism_Homo sapiens_hsa00620	0.91752726
37	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.91489371
38	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.91114438
39	Estrogen signaling pathway_Homo sapiens_hsa04915	0.90020516
40	Propanoate metabolism_Homo sapiens_hsa00640	0.89947531
41	Fatty acid degradation_Homo sapiens_hsa00071	0.88492948
42	GnRH signaling pathway_Homo sapiens_hsa04912	0.87456651
43	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.86170820
44	ABC transporters_Homo sapiens_hsa02010	0.85827119
45	Retinol metabolism_Homo sapiens_hsa00830	0.83372509
46	Tryptophan metabolism_Homo sapiens_hsa00380	0.80531957
47	cAMP signaling pathway_Homo sapiens_hsa04024	0.79051807
48	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.76754775
49	Glutamatergic synapse_Homo sapiens_hsa04724	0.73663412
50	Cholinergic synapse_Homo sapiens_hsa04725	0.69245051
51	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.69089986
52	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.68535628
53	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.66106342
54	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.63538635
55	Renin secretion_Homo sapiens_hsa04924	0.62972414
56	Taste transduction_Homo sapiens_hsa04742	0.60024114
57	Arginine biosynthesis_Homo sapiens_hsa00220	0.58858924
58	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.58828210
59	Axon guidance_Homo sapiens_hsa04360	0.58601619
60	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.56783265
61	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.55148780
62	Melanogenesis_Homo sapiens_hsa04916	0.53444942
63	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.53263839
64	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.52998208
65	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.51561007
66	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.50801249
67	Pancreatic secretion_Homo sapiens_hsa04972	0.50310963
68	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.50010581
69	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.49003368
70	Amphetamine addiction_Homo sapiens_hsa05031	0.48474791
71	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.48049372
72	Phototransduction_Homo sapiens_hsa04744	0.46726327
73	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.46093118
74	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.44924919
75	Gap junction_Homo sapiens_hsa04540	0.43821976
76	Adherens junction_Homo sapiens_hsa04520	0.43719559
77	Type II diabetes mellitus_Homo sapiens_hsa04930	0.42681734
78	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.41749585
79	PPAR signaling pathway_Homo sapiens_hsa03320	0.40665666
80	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.39924601
81	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.37750194
82	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.36932237
83	Calcium signaling pathway_Homo sapiens_hsa04020	0.36546915
84	Insulin resistance_Homo sapiens_hsa04931	0.35323311
85	Long-term potentiation_Homo sapiens_hsa04720	0.31757520
86	Rap1 signaling pathway_Homo sapiens_hsa04015	0.30632701
87	Amoebiasis_Homo sapiens_hsa05146	0.30301327
88	Fatty acid metabolism_Homo sapiens_hsa01212	0.30192110
89	Platelet activation_Homo sapiens_hsa04611	0.30152683
90	Phenylalanine metabolism_Homo sapiens_hsa00360	0.29608175
91	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.26383049
92	Cocaine addiction_Homo sapiens_hsa05030	0.25449737
93	Mineral absorption_Homo sapiens_hsa04978	0.24378448
94	Arginine and proline metabolism_Homo sapiens_hsa00330	0.24044126
95	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.23185266
96	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.22607855
97	Selenocompound metabolism_Homo sapiens_hsa00450	0.20457917
98	Serotonergic synapse_Homo sapiens_hsa04726	0.20281154
99	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.18862689
100	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.17940960

BPIFB6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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