BPIFB9P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of neuron projection regeneration (GO:0070570)8.38318600
2regulation of axon regeneration (GO:0048679)8.38318600
3neuron cell-cell adhesion (GO:0007158)7.28778666
4locomotory exploration behavior (GO:0035641)6.87737310
5pyrimidine nucleobase catabolic process (GO:0006208)6.76150673
6regulation of transmission of nerve impulse (GO:0051969)6.51883761
7peptidyl-threonine dephosphorylation (GO:0035970)6.00545411
8postsynaptic membrane organization (GO:0001941)5.68560591
9nucleobase catabolic process (GO:0046113)5.58509324
10meiotic chromosome segregation (GO:0045132)5.42366125
11positive regulation of synaptic transmission, glutamatergic (GO:0051968)5.38955840
12presynaptic membrane assembly (GO:0097105)5.21206100
13cerebral cortex radially oriented cell migration (GO:0021799)5.19885811
14positive regulation of neurological system process (GO:0031646)5.06981418
15protein K11-linked deubiquitination (GO:0035871)4.85190209
16regulation of synapse maturation (GO:0090128)4.85101399
17protein localization to synapse (GO:0035418)4.60158414
18auditory behavior (GO:0031223)4.42675657
19negative regulation of axon extension (GO:0030517)4.38166567
20neurotransmitter-gated ion channel clustering (GO:0072578)4.37883780
21presynaptic membrane organization (GO:0097090)4.29868799
22positive regulation of amino acid transport (GO:0051957)4.28394265
23glycosphingolipid biosynthetic process (GO:0006688)4.26746915
24L-fucose catabolic process (GO:0042355)4.22121051
25fucose catabolic process (GO:0019317)4.22121051
26L-fucose metabolic process (GO:0042354)4.22121051
27snRNA processing (GO:0016180)4.18427902
28central nervous system projection neuron axonogenesis (GO:0021952)4.14005840
29inositol metabolic process (GO:0006020)4.06035538
30exploration behavior (GO:0035640)4.04703446
31lysine metabolic process (GO:0006553)4.03614752
32lysine catabolic process (GO:0006554)4.03614752
33positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021104.02913504
34mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)4.02913504
35positive regulation of triglyceride biosynthetic process (GO:0010867)3.78089355
36snRNA metabolic process (GO:0016073)3.74130221
37mechanosensory behavior (GO:0007638)3.65018751
38dendritic spine morphogenesis (GO:0060997)3.64339901
39rRNA catabolic process (GO:0016075)3.63838559
40mitochondrion degradation (GO:0000422)3.63721025
41acrosome assembly (GO:0001675)3.50766446
42vocalization behavior (GO:0071625)3.50117098
43positive regulation of synapse maturation (GO:0090129)3.49165866
44regulation of MHC class II biosynthetic process (GO:0045346)3.48938222
45ionotropic glutamate receptor signaling pathway (GO:0035235)3.46646690
46kynurenine metabolic process (GO:0070189)3.40625480
47central nervous system neuron axonogenesis (GO:0021955)3.38250805
48carbohydrate phosphorylation (GO:0046835)3.37886362
49tryptophan catabolic process (GO:0006569)3.35135909
50indole-containing compound catabolic process (GO:0042436)3.35135909
51indolalkylamine catabolic process (GO:0046218)3.35135909
52telencephalon development (GO:0021537)3.30744616
53telencephalon cell migration (GO:0022029)3.29967177
54negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.28159696
55negative regulation of translation, ncRNA-mediated (GO:0040033)3.28159696
56regulation of translation, ncRNA-mediated (GO:0045974)3.28159696
57cell migration in hindbrain (GO:0021535)3.27093291
58dendrite morphogenesis (GO:0048813)3.25097074
59gamma-aminobutyric acid transport (GO:0015812)3.24716376
60nerve growth factor signaling pathway (GO:0038180)3.23266433
61histone H3-K4 trimethylation (GO:0080182)3.23054052
62negative regulation of axonogenesis (GO:0050771)3.22829532
63startle response (GO:0001964)3.15839883
64motor neuron axon guidance (GO:0008045)3.15238755
65monoubiquitinated protein deubiquitination (GO:0035520)3.12629837
66glutamate receptor signaling pathway (GO:0007215)3.12161306
67forebrain cell migration (GO:0021885)3.09907023
68reciprocal DNA recombination (GO:0035825)3.05459713
69reciprocal meiotic recombination (GO:0007131)3.05459713
70auditory receptor cell stereocilium organization (GO:0060088)3.05171841
71regulation of triglyceride biosynthetic process (GO:0010866)3.05120247
72negative regulation of astrocyte differentiation (GO:0048712)3.02520224
73regulation of short-term neuronal synaptic plasticity (GO:0048172)3.01666567
74synaptic transmission, glutamatergic (GO:0035249)3.01512935
75granulocyte differentiation (GO:0030851)3.00999556
76N-glycan processing (GO:0006491)3.00216887
77central nervous system myelination (GO:0022010)2.97390618
78axon ensheathment in central nervous system (GO:0032291)2.97390618
79ganglioside metabolic process (GO:0001573)2.93008317
80aspartate family amino acid catabolic process (GO:0009068)2.92888203
81positive regulation of heat generation (GO:0031652)2.92635906
82Golgi to endosome transport (GO:0006895)2.86144829
83response to auditory stimulus (GO:0010996)2.84929382
84response to inactivity (GO:0014854)2.84377140
85regulation of Rac GTPase activity (GO:0032314)2.83380698
86UDP-N-acetylglucosamine metabolic process (GO:0006047)2.82096156
87regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.81414299
88inner ear receptor stereocilium organization (GO:0060122)2.81011680
89positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.79178734
90regulation of synaptic transmission, glutamatergic (GO:0051966)2.72945457
91regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.72612800
92N-acetylneuraminate metabolic process (GO:0006054)2.72430916
93regulation of glutamate secretion (GO:0014048)2.71602595
94sialylation (GO:0097503)2.69060735
95cerebral cortex cell migration (GO:0021795)2.68594388
96spinal cord motor neuron differentiation (GO:0021522)2.64938096
97indolalkylamine metabolic process (GO:0006586)2.63121347
98import into cell (GO:0098657)2.62126619
99calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.61546715
100neuron fate determination (GO:0048664)2.61288190

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.89646604
2EZH2_22144423_ChIP-Seq_EOC_Human3.53007003
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.83598781
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.80489816
5AR_21572438_ChIP-Seq_LNCaP_Human2.60342878
6ZNF274_21170338_ChIP-Seq_K562_Hela2.54181177
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.52951651
8TAF15_26573619_Chip-Seq_HEK293_Human2.50027576
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.41074387
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.35652168
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.25228912
12SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.19891708
13REST_21632747_ChIP-Seq_MESCs_Mouse2.11229415
14FUS_26573619_Chip-Seq_HEK293_Human2.09966962
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07717000
16DROSHA_22980978_ChIP-Seq_HELA_Human1.94309454
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91159286
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90489084
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.87704711
20ER_23166858_ChIP-Seq_MCF-7_Human1.85217161
21SMAD4_21799915_ChIP-Seq_A2780_Human1.83231919
22EWS_26573619_Chip-Seq_HEK293_Human1.78897544
23TCF4_23295773_ChIP-Seq_U87_Human1.75435237
24CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.74428282
25CBP_20019798_ChIP-Seq_JUKART_Human1.73017308
26IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.73017308
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71405399
28POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.70930342
29TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70930342
30VDR_22108803_ChIP-Seq_LS180_Human1.68883712
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64755406
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.56632925
33SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52679971
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.50083715
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.47509777
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47030016
37OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42300079
38P300_19829295_ChIP-Seq_ESCs_Human1.42056753
39BCAT_22108803_ChIP-Seq_LS180_Human1.41993700
40STAT3_23295773_ChIP-Seq_U87_Human1.41888977
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39867057
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35451694
43NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32138743
44TCF4_18268006_ChIP-ChIP_LS174T_Human1.31309143
45REST_18959480_ChIP-ChIP_MESCs_Mouse1.30129011
46JARID2_20064375_ChIP-Seq_MESCs_Mouse1.30101428
47KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.29530511
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29431862
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.27035521
50AHR_22903824_ChIP-Seq_MCF-7_Human1.27025964
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.25527020
52TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25247039
53WDR5_24793694_ChIP-Seq_LNCAP_Human1.23358341
54ARNT_22903824_ChIP-Seq_MCF-7_Human1.23296264
55RUNX2_22187159_ChIP-Seq_PCA_Human1.22475653
56GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21366139
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.20831084
58AR_25329375_ChIP-Seq_VCAP_Human1.20208684
59RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.19411797
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.18840547
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17824535
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.17047506
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15597003
64SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.14902052
65RNF2_27304074_Chip-Seq_NSC_Mouse1.14302660
66JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14180632
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13322959
68EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10530768
69EZH2_27304074_Chip-Seq_ESCs_Mouse1.09590092
70TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09417816
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08869480
72SMAD3_21741376_ChIP-Seq_HESCs_Human1.08859472
73KDM2B_26808549_Chip-Seq_REH_Human1.08801041
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07818496
75PRDM14_20953172_ChIP-Seq_ESCs_Human1.06973960
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06648110
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06477264
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.06195682
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06180063
80SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.05964304
81CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05712432
82SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04828009
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04539003
84NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04539003
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.04256974
86SMAD4_21741376_ChIP-Seq_EPCs_Human1.03362391
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02342235
88SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02231446
89JUN_21703547_ChIP-Seq_K562_Human1.01413898
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.00950861
91CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99457420
92PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98938274
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98361679
94IRF1_19129219_ChIP-ChIP_H3396_Human0.97974591
95SMAD4_21741376_ChIP-Seq_HESCs_Human0.97919655
96OCT1_27270436_Chip-Seq_PROSTATE_Human0.97633275
97SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.97195311
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97031226
99TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96746551
100PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96513480

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004782_abnormal_surfactant_physiolog4.69119249
2MP0002736_abnormal_nociception_after4.57752181
3MP0001986_abnormal_taste_sensitivity4.18664436
4MP0001968_abnormal_touch/_nociception3.89028958
5MP0002735_abnormal_chemical_nociception2.95213990
6MP0004859_abnormal_synaptic_plasticity2.93534165
7MP0005423_abnormal_somatic_nervous2.90146643
8MP0000631_abnormal_neuroendocrine_gland2.70103848
9MP0000569_abnormal_digit_pigmentation2.57529715
10MP0004885_abnormal_endolymph2.48374884
11MP0004270_analgesia2.40660497
12MP0003635_abnormal_synaptic_transmissio2.23573825
13MP0009745_abnormal_behavioral_response2.08016140
14MP0003136_yellow_coat_color2.04900107
15MP0005187_abnormal_penis_morphology2.03929803
16MP0008872_abnormal_physiological_respon1.99591995
17MP0002063_abnormal_learning/memory/cond1.99027901
18MP0002272_abnormal_nervous_system1.95812229
19MP0004484_altered_response_of1.92355172
20MP0002638_abnormal_pupillary_reflex1.92242637
21MP0005551_abnormal_eye_electrophysiolog1.90813082
22MP0001970_abnormal_pain_threshold1.90544785
23MP0002733_abnormal_thermal_nociception1.87081192
24MP0002064_seizures1.86279960
25MP0009046_muscle_twitch1.80303976
26MP0002837_dystrophic_cardiac_calcinosis1.76515745
27MP0005386_behavior/neurological_phenoty1.75385940
28MP0004924_abnormal_behavior1.75385940
29MP0002557_abnormal_social/conspecific_i1.74754098
30MP0002572_abnormal_emotion/affect_behav1.71580560
31MP0001188_hyperpigmentation1.69314609
32MP0003195_calcinosis1.61974872
33MP0005645_abnormal_hypothalamus_physiol1.54216977
34MP0001486_abnormal_startle_reflex1.49471694
35MP0003632_abnormal_nervous_system1.49428344
36MP0002067_abnormal_sensory_capabilities1.47915088
37MP0000778_abnormal_nervous_system1.47781215
38MP0002734_abnormal_mechanical_nocicepti1.46899426
39MP0002160_abnormal_reproductive_system1.41915947
40MP0005646_abnormal_pituitary_gland1.40641709
41MP0002332_abnormal_exercise_endurance1.36025673
42MP0004215_abnormal_myocardial_fiber1.33760844
43MP0004742_abnormal_vestibular_system1.30960276
44MP0002882_abnormal_neuron_morphology1.28942320
45MP0003646_muscle_fatigue1.27220115
46MP0003631_nervous_system_phenotype1.26788505
47MP0002184_abnormal_innervation1.25770292
48MP0003880_abnormal_central_pattern1.24962990
49MP0004811_abnormal_neuron_physiology1.23341002
50MP0001501_abnormal_sleep_pattern1.22030650
51MP0005310_abnormal_salivary_gland1.21770108
52MP0005171_absent_coat_pigmentation1.21182427
53MP0004142_abnormal_muscle_tone1.18959545
54MP0004147_increased_porphyrin_level1.17921531
55MP0001502_abnormal_circadian_rhythm1.16207789
56MP0002876_abnormal_thyroid_physiology1.10724634
57MP0004381_abnormal_hair_follicle1.09288235
58MP0008875_abnormal_xenobiotic_pharmacok1.09087354
59MP0000751_myopathy1.06625613
60MP0002229_neurodegeneration1.06119207
61MP0005174_abnormal_tail_pigmentation1.04787417
62MP0006276_abnormal_autonomic_nervous1.04768273
63MP0002751_abnormal_autonomic_nervous1.04638581
64MP0000015_abnormal_ear_pigmentation1.04509168
65MP0004130_abnormal_muscle_cell1.03891527
66MP0002152_abnormal_brain_morphology1.03342780
67MP0003315_abnormal_perineum_morphology0.97236352
68MP0000955_abnormal_spinal_cord0.95906596
69MP0005389_reproductive_system_phenotype0.94247459
70MP0003633_abnormal_nervous_system0.93917122
71MP0004133_heterotaxia0.93249047
72MP0005075_abnormal_melanosome_morpholog0.90256039
73MP0001440_abnormal_grooming_behavior0.88946330
74MP0002066_abnormal_motor_capabilities/c0.88666526
75MP0002752_abnormal_somatic_nervous0.87931540
76MP0001984_abnormal_olfaction0.87477086
77MP0003638_abnormal_response/metabolism_0.87324593
78MP0006292_abnormal_olfactory_placode0.86285574
79MP0001764_abnormal_homeostasis0.85542254
80MP0001485_abnormal_pinna_reflex0.84943890
81MP0005410_abnormal_fertilization0.82338353
82MP0005408_hypopigmentation0.81927025
83MP0000920_abnormal_myelination0.79994713
84MP0003011_delayed_dark_adaptation0.79601861
85MP0005195_abnormal_posterior_eye0.79129560
86MP0001919_abnormal_reproductive_system0.78623156
87MP0005332_abnormal_amino_acid0.78178543
88MP0000372_irregular_coat_pigmentation0.78058186
89MP0000427_abnormal_hair_cycle0.77978205
90MP0006072_abnormal_retinal_apoptosis0.77092166
91MP0009764_decreased_sensitivity_to0.73225690
92MP0003115_abnormal_respiratory_system0.72885574
93MP0002095_abnormal_skin_pigmentation0.72805621
94MP0003634_abnormal_glial_cell0.72400749
95MP0004085_abnormal_heartbeat0.70546877
96MP0005085_abnormal_gallbladder_physiolo0.70511342
97MP0000647_abnormal_sebaceous_gland0.69846766
98MP0004084_abnormal_cardiac_muscle0.69774235
99MP0005167_abnormal_blood-brain_barrier0.68213964
100MP0005253_abnormal_eye_physiology0.66181343

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)8.94367693
2Optic nerve hypoplasia (HP:0000609)5.50297445
3Abnormality of the septum pellucidum (HP:0007375)4.92018146
4Abnormality of the sella turcica (HP:0002679)4.90558822
5Aplasia/Hypoplasia of the optic nerve (HP:0008058)4.71095629
6Absent septum pellucidum (HP:0001331)4.65185005
7Hyperventilation (HP:0002883)4.16984325
8Stomach cancer (HP:0012126)3.97832555
9Epileptic encephalopathy (HP:0200134)3.88458569
10True hermaphroditism (HP:0010459)3.81965747
11Broad-based gait (HP:0002136)3.79171587
12Pancreatic fibrosis (HP:0100732)3.60135542
13Pancreatic cysts (HP:0001737)3.57607034
14Aplasia/Hypoplasia affecting the fundus (HP:0008057)3.44055014
15Rimmed vacuoles (HP:0003805)3.39481646
16Congenital stationary night blindness (HP:0007642)3.33339026
17Medial flaring of the eyebrow (HP:0010747)3.30401269
18Nephronophthisis (HP:0000090)3.21926963
19Lissencephaly (HP:0001339)3.12086474
20Growth hormone deficiency (HP:0000824)3.08333964
21Protruding tongue (HP:0010808)3.07708404
22Abnormality of midbrain morphology (HP:0002418)3.02984197
23Molar tooth sign on MRI (HP:0002419)3.02984197
24Gait imbalance (HP:0002141)2.93585996
25Progressive inability to walk (HP:0002505)2.87891094
26Attenuation of retinal blood vessels (HP:0007843)2.87169749
27Congenital primary aphakia (HP:0007707)2.72551572
28Cerebellar dysplasia (HP:0007033)2.72339706
29Focal seizures (HP:0007359)2.71490016
30Focal motor seizures (HP:0011153)2.70426425
31Bile duct proliferation (HP:0001408)2.66711626
32Abnormal biliary tract physiology (HP:0012439)2.66711626
33Abnormal rod and cone electroretinograms (HP:0008323)2.59660181
34Abnormality of the renal medulla (HP:0100957)2.57220500
35Cystic liver disease (HP:0006706)2.55286623
36Drooling (HP:0002307)2.54144087
37Gaze-evoked nystagmus (HP:0000640)2.52642698
38Alveolar cell carcinoma (HP:0006519)2.48167689
39Amblyopia (HP:0000646)2.47530208
40Nephrogenic diabetes insipidus (HP:0009806)2.47223194
41Type II lissencephaly (HP:0007260)2.45724886
42Agitation (HP:0000713)2.43516341
43Decreased circulating renin level (HP:0003351)2.40465711
44Thyroid-stimulating hormone excess (HP:0002925)2.38838910
45Biliary tract neoplasm (HP:0100574)2.38333890
46Furrowed tongue (HP:0000221)2.38185608
47Excessive salivation (HP:0003781)2.34630832
48Neoplasm of the tracheobronchial system (HP:0100552)2.30356174
49Primary amenorrhea (HP:0000786)2.28307619
50Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.28290512
51Abnormality of alanine metabolism (HP:0010916)2.28290512
52Hyperalaninemia (HP:0003348)2.28290512
53Pachygyria (HP:0001302)2.24763538
54Absent rod-and cone-mediated responses on ERG (HP:0007688)2.23125214
55Coronal craniosynostosis (HP:0004440)2.21155105
56Megalencephaly (HP:0001355)2.20678385
57Aplasia/Hypoplasia of the tongue (HP:0010295)2.18312524
58Primary adrenal insufficiency (HP:0008207)2.18191813
59Poor coordination (HP:0002370)2.16924532
60Pigmentary retinal degeneration (HP:0001146)2.14512346
61Vaginal atresia (HP:0000148)2.13377278
62Occipital encephalocele (HP:0002085)2.12739933
63Bundle branch block (HP:0011710)2.12021349
64Dialeptic seizures (HP:0011146)2.12020732
65Congenital hepatic fibrosis (HP:0002612)2.05507041
66Chronic hepatic failure (HP:0100626)2.05228020
67Inability to walk (HP:0002540)2.04927711
68Abnormality of the renal cortex (HP:0011035)2.04795652
69Sclerocornea (HP:0000647)2.04744985
70Bony spicule pigmentary retinopathy (HP:0007737)2.04732752
71Chorioretinal atrophy (HP:0000533)2.02982180
72Anencephaly (HP:0002323)2.01930984
73Ketosis (HP:0001946)2.00854185
74Choroideremia (HP:0001139)2.00362732
75Genital tract atresia (HP:0001827)1.99362066
76Febrile seizures (HP:0002373)1.95576649
77Retinitis pigmentosa (HP:0000510)1.93829462
78Heterotopia (HP:0002282)1.90678536
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.89601204
80Polydipsia (HP:0001959)1.88962115
81Abnormal drinking behavior (HP:0030082)1.88962115
82Severe Myopia (HP:0011003)1.83766588
83Tubular atrophy (HP:0000092)1.82351685
84Intestinal atresia (HP:0011100)1.78882126
85Chronic bronchitis (HP:0004469)1.78093189
86Aplasia/Hypoplasia of the brainstem (HP:0007362)1.76147558
87Hypoplasia of the brainstem (HP:0002365)1.76147558
88Polymicrogyria (HP:0002126)1.74521922
89Specific learning disability (HP:0001328)1.71903594
90Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.71048686
91Abnormality of serum amino acid levels (HP:0003112)1.70713965
92Abnormal biliary tract morphology (HP:0012440)1.70240448
93Intellectual disability, severe (HP:0010864)1.70234602
94Hamartoma of the eye (HP:0010568)1.69892705
95Conical tooth (HP:0000698)1.68026628
96Postaxial foot polydactyly (HP:0001830)1.65928838
97Atonic seizures (HP:0010819)1.65848145
98Aplasia/Hypoplasia of the fovea (HP:0008060)1.65690262
99Hypoplasia of the fovea (HP:0007750)1.65690262
100Decreased central vision (HP:0007663)1.65030847

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK7.40914780
2MARK14.79969095
3BLK4.12635391
4ERBB43.50435471
5MAP3K93.10276527
6MAP4K23.02659313
7FRK2.65376141
8IRAK22.63784941
9DYRK22.17143515
10MAPK131.98020168
11IRAK11.95095323
12MAP2K71.94259021
13PINK11.87418577
14NTRK21.84069275
15CAMKK21.75686900
16YES11.54618493
17CAMK1D1.51300814
18MAP3K41.46202685
19TNIK1.42182449
20EPHA41.39676719
21TAOK31.31899196
22ADRBK21.28453834
23DAPK21.26092220
24SGK21.23683430
25MKNK21.19232651
26NUAK11.18219221
27SGK2231.17035679
28SGK4941.17035679
29DYRK31.15137423
30RPS6KB21.11090325
31CAMK1G1.04466104
32CAMK41.02175460
33PBK0.92048095
34ARAF0.87182074
35RPS6KA40.85559964
36PAK30.84578701
37WNK40.83127343
38WNK30.79458806
39NTRK30.77167383
40GSK3A0.74901955
41PDPK10.72727708
42PDK10.72507805
43ROCK10.72224728
44MAP2K40.71227824
45SGK30.70178451
46CAMK2B0.67979273
47ERBB20.66243759
48CDK50.66004182
49LATS10.64243456
50OBSCN0.62714923
51MAPKAPK50.61068569
52MAPK150.59066445
53PKN10.58442688
54PRKCG0.56991561
55STK160.56240093
56PRKCE0.54864415
57CSNK1G20.54413023
58RAF10.54377511
59ADRBK10.53203165
60ZAK0.52371126
61MAP3K130.51712907
62MKNK10.50895902
63CSNK1A1L0.50696330
64GRK10.49212284
65CAMKK10.49003063
66STK390.47461455
67CSNK1G10.43624087
68CAMK10.43505866
69AKT30.43317979
70CAMK2A0.41187133
71SGK10.41085687
72HIPK20.40958116
73CAMK2D0.40840434
74BCR0.40826246
75MARK30.40069398
76CSNK1G30.38100606
77TYRO30.35350112
78LYN0.34797014
79PHKG10.33373623
80PHKG20.33373623
81TNK20.33080722
82KSR10.33002146
83DMPK0.32634077
84PRKG10.32307319
85SIK20.31419187
86PDGFRB0.30817684
87PDK20.30720120
88CSNK1E0.30179364
89IGF1R0.29862676
90CAMK2G0.29200370
91PLK20.28315133
92RPS6KB10.28136306
93PIK3CG0.26731902
94ERBB30.26104789
95PRKD10.25901182
96TRPM70.25680471
97GRK50.25173288
98MAP3K70.25056178
99NEK20.24299535
100PRKCQ0.24051189

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.28551575
2Regulation of autophagy_Homo sapiens_hsa041403.10780195
3Caffeine metabolism_Homo sapiens_hsa002322.46220427
4Phototransduction_Homo sapiens_hsa047442.36803379
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.30818035
6Cocaine addiction_Homo sapiens_hsa050302.27859880
7Linoleic acid metabolism_Homo sapiens_hsa005912.04826574
8Long-term depression_Homo sapiens_hsa047301.99807901
9Circadian entrainment_Homo sapiens_hsa047131.80048818
10Dopaminergic synapse_Homo sapiens_hsa047281.77874229
11Glutamatergic synapse_Homo sapiens_hsa047241.77743194
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.74523490
13Olfactory transduction_Homo sapiens_hsa047401.73720380
14Ether lipid metabolism_Homo sapiens_hsa005651.72122903
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.71580825
16Amphetamine addiction_Homo sapiens_hsa050311.66489484
17Propanoate metabolism_Homo sapiens_hsa006401.66159590
18Morphine addiction_Homo sapiens_hsa050321.61201005
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.58940769
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.56632850
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.56136223
22Lysine degradation_Homo sapiens_hsa003101.55589406
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.51289152
24Circadian rhythm_Homo sapiens_hsa047101.48657119
25Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.43092141
26GABAergic synapse_Homo sapiens_hsa047271.42190302
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40306693
28Tryptophan metabolism_Homo sapiens_hsa003801.40032244
29Calcium signaling pathway_Homo sapiens_hsa040201.36543851
30Insulin secretion_Homo sapiens_hsa049111.36125636
31FoxO signaling pathway_Homo sapiens_hsa040681.27569436
32Inositol phosphate metabolism_Homo sapiens_hsa005621.25024405
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.24626562
34Selenocompound metabolism_Homo sapiens_hsa004501.24267359
35Sulfur metabolism_Homo sapiens_hsa009201.22665024
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.21945521
37Serotonergic synapse_Homo sapiens_hsa047261.18044067
38Axon guidance_Homo sapiens_hsa043601.17005653
39cAMP signaling pathway_Homo sapiens_hsa040241.16955665
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14829378
41Salivary secretion_Homo sapiens_hsa049701.11611571
42AMPK signaling pathway_Homo sapiens_hsa041521.10203691
43Cholinergic synapse_Homo sapiens_hsa047251.09988190
44Steroid biosynthesis_Homo sapiens_hsa001001.07662623
45Oxytocin signaling pathway_Homo sapiens_hsa049211.07599932
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07166844
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04512096
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.02748709
49Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00269178
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99627107
51Glucagon signaling pathway_Homo sapiens_hsa049220.98269891
52Nitrogen metabolism_Homo sapiens_hsa009100.97918188
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95282450
54Ovarian steroidogenesis_Homo sapiens_hsa049130.95111604
55Butanoate metabolism_Homo sapiens_hsa006500.90426201
56Type II diabetes mellitus_Homo sapiens_hsa049300.90310569
57Basal transcription factors_Homo sapiens_hsa030220.89753731
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89576719
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88667542
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88500088
61PPAR signaling pathway_Homo sapiens_hsa033200.87640175
62Fatty acid degradation_Homo sapiens_hsa000710.84643855
63Sulfur relay system_Homo sapiens_hsa041220.80751022
64MAPK signaling pathway_Homo sapiens_hsa040100.78653510
65Gastric acid secretion_Homo sapiens_hsa049710.78200982
66Taste transduction_Homo sapiens_hsa047420.74477521
67Estrogen signaling pathway_Homo sapiens_hsa049150.70043769
68Long-term potentiation_Homo sapiens_hsa047200.69312975
69Renin secretion_Homo sapiens_hsa049240.68270207
70Fatty acid metabolism_Homo sapiens_hsa012120.65238937
71Choline metabolism in cancer_Homo sapiens_hsa052310.62504507
72Dorso-ventral axis formation_Homo sapiens_hsa043200.61124872
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59589320
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.57474285
75Ras signaling pathway_Homo sapiens_hsa040140.57242763
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57176175
77GnRH signaling pathway_Homo sapiens_hsa049120.53760381
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53292431
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51440347
80Histidine metabolism_Homo sapiens_hsa003400.50161976
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.49040187
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.48073505
83ErbB signaling pathway_Homo sapiens_hsa040120.47845753
84Platelet activation_Homo sapiens_hsa046110.46326203
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42563037
86Thyroid hormone synthesis_Homo sapiens_hsa049180.42356504
87Insulin resistance_Homo sapiens_hsa049310.41467607
88Alcoholism_Homo sapiens_hsa050340.41345094
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40164706
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39629756
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37731731
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35902549
93VEGF signaling pathway_Homo sapiens_hsa043700.35556369
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.35259684
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.32460658
96Melanogenesis_Homo sapiens_hsa049160.31841278
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.31089890
98RNA degradation_Homo sapiens_hsa030180.30956845
99Gap junction_Homo sapiens_hsa045400.30658834
100Pyruvate metabolism_Homo sapiens_hsa006200.30602569

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