BPNT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1water-soluble vitamin biosynthetic process (GO:0042364)6.27225814
2behavioral response to nicotine (GO:0035095)5.06806056
3L-phenylalanine catabolic process (GO:0006559)5.05779825
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.05779825
5DNA deamination (GO:0045006)5.03784599
6intestinal absorption (GO:0050892)5.00132240
7intestinal cholesterol absorption (GO:0030299)4.99180299
8mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.95424460
9mitochondrial respiratory chain complex I assembly (GO:0032981)4.95424460
10NADH dehydrogenase complex assembly (GO:0010257)4.95424460
11protein complex biogenesis (GO:0070271)4.94528048
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.82933568
13L-phenylalanine metabolic process (GO:0006558)4.82933568
14sulfation (GO:0051923)4.75247593
15mitochondrial respiratory chain complex assembly (GO:0033108)4.66132965
16drug transmembrane transport (GO:0006855)4.58116959
17drug catabolic process (GO:0042737)4.00486913
18aromatic amino acid family catabolic process (GO:0009074)3.97451221
19Golgi transport vesicle coating (GO:0048200)3.86022912
20COPI coating of Golgi vesicle (GO:0048205)3.86022912
21peptide hormone processing (GO:0016486)3.75461672
22signal peptide processing (GO:0006465)3.74340388
23positive regulation of fatty acid oxidation (GO:0046321)3.71735871
24glyoxylate metabolic process (GO:0046487)3.71582111
25drug transport (GO:0015893)3.69618046
26lysine catabolic process (GO:0006554)3.63895794
27lysine metabolic process (GO:0006553)3.63895794
28cysteine metabolic process (GO:0006534)3.63338624
29endocrine pancreas development (GO:0031018)3.57783272
30urate metabolic process (GO:0046415)3.46275397
31angiotensin maturation (GO:0002003)3.44228566
32vitamin biosynthetic process (GO:0009110)3.37358661
33regulation of bile acid biosynthetic process (GO:0070857)3.37236459
34* purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.35944697
353-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.35944697
36magnesium ion transport (GO:0015693)3.35632811
37flavonoid metabolic process (GO:0009812)3.34667065
38ATP synthesis coupled proton transport (GO:0015986)3.30782579
39energy coupled proton transport, down electrochemical gradient (GO:0015985)3.30782579
40replicative senescence (GO:0090399)3.29105200
41mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.27517124
42regulation of glomerulus development (GO:0090192)3.26806543
43COPII vesicle coating (GO:0048208)3.23138475
44homocysteine metabolic process (GO:0050667)3.22872669
45hormone catabolic process (GO:0042447)3.22698342
46triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.21346552
47preassembly of GPI anchor in ER membrane (GO:0016254)3.19731506
48regulation of cholesterol esterification (GO:0010872)3.17956514
49maturation of 5.8S rRNA (GO:0000460)3.17403141
50tryptophan metabolic process (GO:0006568)3.14665636
51tyrosine metabolic process (GO:0006570)3.14261696
52fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.13365934
53sulfur amino acid catabolic process (GO:0000098)3.13246873
54kynurenine metabolic process (GO:0070189)3.12620763
55indolalkylamine metabolic process (GO:0006586)3.12425126
56aspartate family amino acid catabolic process (GO:0009068)3.12404149
57tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.12172610
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.12172610
59aromatic amino acid family metabolic process (GO:0009072)3.11943829
60positive regulation of fatty acid transport (GO:2000193)3.11872204
61membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.10585637
62cobalamin metabolic process (GO:0009235)3.08507696
63protein K6-linked ubiquitination (GO:0085020)3.08287485
64branched-chain amino acid catabolic process (GO:0009083)3.06794582
65exogenous drug catabolic process (GO:0042738)3.06444877
66ER overload response (GO:0006983)3.06316970
67tryptophan catabolic process (GO:0006569)3.05509054
68indole-containing compound catabolic process (GO:0042436)3.05509054
69indolalkylamine catabolic process (GO:0046218)3.05509054
70cellular response to ATP (GO:0071318)3.05224622
71short-chain fatty acid metabolic process (GO:0046459)3.05016363
72drug metabolic process (GO:0017144)3.03694114
73cell proliferation in forebrain (GO:0021846)3.02882340
74NADH metabolic process (GO:0006734)3.02404343
75cellular ketone body metabolic process (GO:0046950)3.01395214
76platelet dense granule organization (GO:0060155)3.00481587
77glutathione biosynthetic process (GO:0006750)3.00264975
78mannosylation (GO:0097502)2.99498343
79nonribosomal peptide biosynthetic process (GO:0019184)2.98896205
80positive regulation of fatty acid beta-oxidation (GO:0032000)2.98063344
81pharyngeal system development (GO:0060037)2.97757843
82branched-chain amino acid metabolic process (GO:0009081)2.97729700
83polyol transport (GO:0015791)2.97074158
84establishment of protein localization to mitochondrial membrane (GO:0090151)2.96838765
85protein polyglutamylation (GO:0018095)2.96668877
86fatty acid beta-oxidation (GO:0006635)2.96631311
87regulation of cholesterol homeostasis (GO:2000188)2.96537150
88cytochrome complex assembly (GO:0017004)2.96515356
89nucleotide transmembrane transport (GO:1901679)2.96489947
90maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.95721811
91uronic acid metabolic process (GO:0006063)2.95524702
92glucuronate metabolic process (GO:0019585)2.95524702
93coenzyme catabolic process (GO:0009109)2.93993739
94regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.93885968
95cholesterol efflux (GO:0033344)2.93401290
96cellular modified amino acid catabolic process (GO:0042219)2.93256932
97negative regulation of digestive system process (GO:0060457)2.92793390
98negative regulation of systemic arterial blood pressure (GO:0003085)2.92470097
99cellular glucuronidation (GO:0052695)2.91397231
100glutathione derivative metabolic process (GO:1901685)2.91156243
101glutathione derivative biosynthetic process (GO:1901687)2.91156243
102negative regulation of membrane potential (GO:0045837)2.89929113
103fatty acid catabolic process (GO:0009062)2.89668309
104bile acid biosynthetic process (GO:0006699)2.88334915
105high-density lipoprotein particle remodeling (GO:0034375)2.87520598
106somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.87406354
107somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.87406354
108isotype switching (GO:0045190)2.87406354
109very-low-density lipoprotein particle assembly (GO:0034379)2.87154638
110triglyceride homeostasis (GO:0070328)2.87028480
111acylglycerol homeostasis (GO:0055090)2.87028480
112mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.86643275
113cholesterol biosynthetic process (GO:0006695)2.86166662
114peptide biosynthetic process (GO:0043043)2.86025079
115membrane repolarization during action potential (GO:0086011)2.84200886
116replication fork processing (GO:0031297)2.84196734
117prostate gland growth (GO:0060736)2.82898872
118negative regulation of mast cell activation (GO:0033004)2.81815501
119cellular amino acid catabolic process (GO:0009063)2.81558199
120glutathione metabolic process (GO:0006749)2.81493886
121very long-chain fatty acid metabolic process (GO:0000038)2.81022039
122renal absorption (GO:0070293)2.80750423
123nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.80413748
124lipoprotein metabolic process (GO:0042157)2.79536072
125regulation of type B pancreatic cell apoptotic process (GO:2000674)2.79476229
126exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.79447677
127reverse cholesterol transport (GO:0043691)2.79131012
128fatty acid oxidation (GO:0019395)2.78517624
129cytidine metabolic process (GO:0046087)2.77694275
130cytidine catabolic process (GO:0006216)2.77694275
131cytidine deamination (GO:0009972)2.77694275
132response to mercury ion (GO:0046689)2.76797728
133pseudouridine synthesis (GO:0001522)2.76588491
134somatic diversification of immunoglobulins (GO:0016445)2.76361341
135alpha-amino acid catabolic process (GO:1901606)2.76306299
136proline metabolic process (GO:0006560)2.75486548
137bile acid metabolic process (GO:0008206)2.75425550
138peptide metabolic process (GO:0006518)2.75124311
139cellular response to exogenous dsRNA (GO:0071360)2.75101542
140regulation of triglyceride catabolic process (GO:0010896)2.74880932
141lipid oxidation (GO:0034440)2.74165023
142aldehyde catabolic process (GO:0046185)2.73850142
143protein import into peroxisome matrix (GO:0016558)2.73410547
144GPI anchor metabolic process (GO:0006505)2.72778924
145fructose metabolic process (GO:0006000)2.72767859
146monocarboxylic acid catabolic process (GO:0072329)2.72403090
147organic cation transport (GO:0015695)2.70713108
148long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.70340379
149alpha-linolenic acid metabolic process (GO:0036109)2.70286568
150ketone body metabolic process (GO:1902224)2.70278878
151protein retention in ER lumen (GO:0006621)2.69784334
152phospholipid efflux (GO:0033700)2.69741970
153fatty-acyl-CoA biosynthetic process (GO:0046949)2.68246241
154* ribonucleoside bisphosphate metabolic process (GO:0033875)2.68050393
155* nucleoside bisphosphate metabolic process (GO:0033865)2.68050393
156* purine nucleoside bisphosphate metabolic process (GO:0034032)2.68050393
157glutamate metabolic process (GO:0006536)2.67946426
158regulation of cell proliferation involved in kidney development (GO:1901722)2.66319125
159somatic recombination of immunoglobulin gene segments (GO:0016447)2.64992526
160negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.64865356
161protein-cofactor linkage (GO:0018065)2.63287802
162cellular anion homeostasis (GO:0030002)2.61972005
163respiratory chain complex IV assembly (GO:0008535)2.61909667
164positive regulation of icosanoid secretion (GO:0032305)2.61543341
165signal transduction involved in regulation of gene expression (GO:0023019)2.59474704
166intracellular protein transmembrane import (GO:0044743)2.59262780
167positive regulation of oligodendrocyte differentiation (GO:0048714)2.58720361
168DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.56774933
169cellular component biogenesis (GO:0044085)2.55475407
170ribosomal small subunit biogenesis (GO:0042274)2.53162698
171transcription elongation from RNA polymerase I promoter (GO:0006362)2.53031901
172resolution of meiotic recombination intermediates (GO:0000712)2.51825574
173fucose catabolic process (GO:0019317)2.51472376
174L-fucose metabolic process (GO:0042354)2.51472376
175L-fucose catabolic process (GO:0042355)2.51472376
176mitochondrion morphogenesis (GO:0070584)2.48581939
177endoderm formation (GO:0001706)2.47462429
178regulation of sequestering of triglyceride (GO:0010889)2.46922140
179electron transport chain (GO:0022900)2.46535184
180negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.46324555
181primary amino compound metabolic process (GO:1901160)2.43582468
182synapsis (GO:0007129)2.42526401
183respiratory electron transport chain (GO:0022904)2.42357286
184positive regulation of glomerulus development (GO:0090193)2.42173929
185positive regulation of triglyceride biosynthetic process (GO:0010867)2.41748734
186tRNA processing (GO:0008033)2.39085515
187serotonin metabolic process (GO:0042428)2.38896793
188indole-containing compound metabolic process (GO:0042430)2.37832857
189L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.37720363
190glycerol metabolic process (GO:0006071)2.36923469

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.61181416
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.50826523
3LXR_22158963_ChIP-Seq_LIVER_Mouse3.77963626
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.74072517
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.73802867
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.16167900
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.13356484
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.07653963
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.01098307
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.96127941
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.95445439
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.89782082
13IRF1_19129219_ChIP-ChIP_H3396_Human2.72791467
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.66488590
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.65823784
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.53575407
17ZNF274_21170338_ChIP-Seq_K562_Hela2.51440166
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.44254246
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.42815465
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.32078171
21VDR_22108803_ChIP-Seq_LS180_Human2.29460184
22CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.27335155
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.24803614
24MYC_18940864_ChIP-ChIP_HL60_Human2.17700807
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.17426772
26NOTCH1_21737748_ChIP-Seq_TLL_Human2.08754377
27SOX2_27498859_Chip-Seq_STOMACH_Mouse2.06947358
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.02408639
29HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.99138956
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.97926071
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.94999873
32GBX2_23144817_ChIP-Seq_PC3_Human1.92306809
33* VDR_23849224_ChIP-Seq_CD4+_Human1.87279959
34ELK1_19687146_ChIP-ChIP_HELA_Human1.82268409
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.82128404
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82086900
37FUS_26573619_Chip-Seq_HEK293_Human1.76408684
38EWS_26573619_Chip-Seq_HEK293_Human1.71883510
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70112771
40* FOXP3_21729870_ChIP-Seq_TREG_Human1.54546561
41AUTS2_25519132_ChIP-Seq_293T-REX_Human1.51663031
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.50041247
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49495856
44GATA4_25053715_ChIP-Seq_YYC3_Human1.46457655
45SOX2_20726797_ChIP-Seq_SW620_Human1.45354781
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.43141217
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.43141217
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42212428
49CDX2_20551321_ChIP-Seq_CACO-2_Human1.40237086
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39939408
51TDRD3_21172665_ChIP-Seq_MCF-7_Human1.39175572
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38835457
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.37874170
54FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.37109136
55TRIM28_21343339_ChIP-Seq_HEK293_Human1.36315056
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.35444592
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.34012303
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.33657526
59FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.32945882
60IGF1R_20145208_ChIP-Seq_DFB_Human1.32549458
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31514945
62TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30733685
63E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.30282930
64ER_23166858_ChIP-Seq_MCF-7_Human1.28664046
65E2F4_17652178_ChIP-ChIP_JURKAT_Human1.26690871
66EED_16625203_ChIP-ChIP_MESCs_Mouse1.26177306
67FOXA2_19822575_ChIP-Seq_HepG2_Human1.24978416
68AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.23677043
69ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.22285992
70TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.22133783
71CREB1_15753290_ChIP-ChIP_HEK293T_Human1.21881439
72ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21572292
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21051252
74GATA1_22025678_ChIP-Seq_K562_Human1.20827008
75ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19562893
76CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.19297602
77CLOCK_20551151_ChIP-Seq_293T_Human1.18975839
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18948450
79TTF2_22483619_ChIP-Seq_HELA_Human1.16848585
80* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.16662662
81TP53_22573176_ChIP-Seq_HFKS_Human1.16291082
82* HNF4A_19822575_ChIP-Seq_HepG2_Human1.13993786
83NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13538182
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13538182
85ESR2_21235772_ChIP-Seq_MCF-7_Human1.12467304
86EZH2_22144423_ChIP-Seq_EOC_Human1.11870063
87HTT_18923047_ChIP-ChIP_STHdh_Human1.11688346
88POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07152912
89HOXB7_26014856_ChIP-Seq_BT474_Human1.06898511
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06885021
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06554032
92CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05624357
93GABP_19822575_ChIP-Seq_HepG2_Human1.04536346
94NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04419950
95IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04101586
96CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02669020
97KDM5A_27292631_Chip-Seq_BREAST_Human1.01590036
98OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01155197
99GATA3_21878914_ChIP-Seq_MCF-7_Human1.00355691
100PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.98892927
101* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98217185
102FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97818289
103TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95352125
104TAF2_19829295_ChIP-Seq_ESCs_Human0.94528625
105STAT3_23295773_ChIP-Seq_U87_Human0.93753684
106NFE2_27457419_Chip-Seq_LIVER_Mouse0.93390416
107FLI1_27457419_Chip-Seq_LIVER_Mouse0.92527403
108ERG_20517297_ChIP-Seq_VCAP_Human0.92463458
109TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90920168
110* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90561441
111SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.90260182
112PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.89998983
113CBP_20019798_ChIP-Seq_JUKART_Human0.89993967
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89993967
115P53_21459846_ChIP-Seq_SAOS-2_Human0.89726193
116SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.89666457
117SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88871276
118CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88734004
119* XRN2_22483619_ChIP-Seq_HELA_Human0.88712617
120KAP1_22055183_ChIP-Seq_ESCs_Mouse0.87891025
121CDX2_22108803_ChIP-Seq_LS180_Human0.87794792
122PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.87726219
123ELK1_22589737_ChIP-Seq_MCF10A_Human0.87658312
124RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87596378
125BCAT_22108803_ChIP-Seq_LS180_Human0.87202752
126MYC_18555785_ChIP-Seq_MESCs_Mouse0.86643504
127* FOXA1_25552417_ChIP-Seq_VCAP_Human0.86498114
128MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.86191469
129AR_20517297_ChIP-Seq_VCAP_Human0.85594788
130ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84949071
131ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84764333
132NANOG_20526341_ChIP-Seq_ESCs_Human0.84529748
133GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84485867
134FOXA1_21572438_ChIP-Seq_LNCaP_Human0.84196218
135PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84144042
136MYC_18358816_ChIP-ChIP_MESCs_Mouse0.84034204
137GATA3_24758297_ChIP-Seq_MCF-7_Human0.83458810
138PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82899695
139SMAD4_21799915_ChIP-Seq_A2780_Human0.82790894
140EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.82535816
141TAL1_26923725_Chip-Seq_HPCs_Mouse0.81165519
142ERA_21632823_ChIP-Seq_H3396_Human0.80248383
143TP63_19390658_ChIP-ChIP_HaCaT_Human0.80019373
144TP63_23658742_ChIP-Seq_EP156T_Human0.78986918
145STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.78503301
146MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.78408397
147REST_19997604_ChIP-ChIP_NEURONS_Mouse0.78225199
148SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.77932731
149GATA6_25053715_ChIP-Seq_YYC3_Human0.77904551
150CTBP2_25329375_ChIP-Seq_LNCAP_Human0.77828902
151P300_19829295_ChIP-Seq_ESCs_Human0.77675592
152TAF15_26573619_Chip-Seq_HEK293_Human0.77625350
153NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.77178477
154SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.76473621
155SALL4_18804426_ChIP-ChIP_XEN_Mouse0.75184456
156NCOR_22424771_ChIP-Seq_293T_Human0.74852852
157GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.73505810
158TCF4_22108803_ChIP-Seq_LS180_Human0.72622376
159SMAD4_21741376_ChIP-Seq_HESCs_Human0.71108872
160SOX2_19829295_ChIP-Seq_ESCs_Human0.71084591
161NANOG_19829295_ChIP-Seq_ESCs_Human0.71084591
162CBP_21632823_ChIP-Seq_H3396_Human0.70461263
163BMI1_23680149_ChIP-Seq_NPCS_Mouse0.69981066
164CTBP1_25329375_ChIP-Seq_LNCAP_Human0.69919429
165SMAD3_21741376_ChIP-Seq_EPCs_Human0.68804483
166REST_21632747_ChIP-Seq_MESCs_Mouse0.68388450
167NR3C1_21868756_ChIP-Seq_MCF10A_Human0.68163396
168FOXM1_26456572_ChIP-Seq_MCF-7_Human0.67739233
169REST_18959480_ChIP-ChIP_MESCs_Mouse0.67151621

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.38297293
2MP0002139_abnormal_hepatobiliary_system5.41697326
3MP0004043_abnormal_pH_regulation4.82798040
4MP0003195_calcinosis3.90065280
5MP0005085_abnormal_gallbladder_physiolo3.73807482
6MP0005365_abnormal_bile_salt3.68890903
7MP0008875_abnormal_xenobiotic_pharmacok3.47754811
8MP0003806_abnormal_nucleotide_metabolis3.28387463
9MP0003646_muscle_fatigue3.21478739
10MP0001666_abnormal_nutrient_absorption3.16359006
11MP0003252_abnormal_bile_duct2.99279290
12MP0005332_abnormal_amino_acid2.83205465
13MP0002160_abnormal_reproductive_system2.69364129
14MP0004019_abnormal_vitamin_homeostasis2.44230607
15MP0009780_abnormal_chondrocyte_physiolo2.34867450
16MP0005389_reproductive_system_phenotype2.28492906
17MP0009643_abnormal_urine_homeostasis2.15777474
18MP0010329_abnormal_lipoprotein_level2.15141599
19MP0009840_abnormal_foam_cell2.09945028
20MP0002876_abnormal_thyroid_physiology2.07402524
21MP0005670_abnormal_white_adipose2.03560824
22MP0003183_abnormal_peptide_metabolism1.98528387
23MP0000537_abnormal_urethra_morphology1.90492057
24MP0004264_abnormal_extraembryonic_tissu1.86323340
25MP0003693_abnormal_embryo_hatching1.79582976
26MP0001919_abnormal_reproductive_system1.77482433
27MP0003283_abnormal_digestive_organ1.75076868
28MP0001756_abnormal_urination1.73396814
29MP0001765_abnormal_ion_homeostasis1.71528244
30MP0002102_abnormal_ear_morphology1.71021440
31MP0002877_abnormal_melanocyte_morpholog1.68420699
32MP0002118_abnormal_lipid_homeostasis1.64488772
33MP0004145_abnormal_muscle_electrophysio1.64480502
34MP0002138_abnormal_hepatobiliary_system1.61339875
35MP0005636_abnormal_mineral_homeostasis1.61198711
36MP0003011_delayed_dark_adaptation1.59730816
37MP0005551_abnormal_eye_electrophysiolog1.59216799
38MP0010386_abnormal_urinary_bladder1.59099303
39MP0004270_analgesia1.56913962
40MP0002938_white_spotting1.56294943
41MP0005379_endocrine/exocrine_gland_phen1.55908971
42MP0002693_abnormal_pancreas_physiology1.43901480
43MP0000013_abnormal_adipose_tissue1.42991248
44MP0005084_abnormal_gallbladder_morpholo1.42752848
45MP0000631_abnormal_neuroendocrine_gland1.41357376
46MP0005220_abnormal_exocrine_pancreas1.40326489
47MP0003718_maternal_effect1.39781916
48MP0000462_abnormal_digestive_system1.36725247
49MP0002078_abnormal_glucose_homeostasis1.35915503
50MP0005174_abnormal_tail_pigmentation1.33896942
51MP0001764_abnormal_homeostasis1.33816576
52MP0001944_abnormal_pancreas_morphology1.33432086
53MP0000049_abnormal_middle_ear1.31937336
54MP0001986_abnormal_taste_sensitivity1.28632044
55MP0000538_abnormal_urinary_bladder1.27555219
56MP0006292_abnormal_olfactory_placode1.25985267
57MP0002736_abnormal_nociception_after1.24455353
58MP0003937_abnormal_limbs/digits/tail_de1.24360269
59MP0003786_premature_aging1.23808504
60MP0002909_abnormal_adrenal_gland1.23291788
61MP0002822_catalepsy1.22549810
62MP0000678_abnormal_parathyroid_gland1.21164192
63MP0004130_abnormal_muscle_cell1.21077940
64MP0005253_abnormal_eye_physiology1.19667085
65MP0001968_abnormal_touch/_nociception1.19482238
66MP0008058_abnormal_DNA_repair1.19442937
67MP0004885_abnormal_endolymph1.19386575
68MP0002638_abnormal_pupillary_reflex1.18612315
69MP0003868_abnormal_feces_composition1.16839426
70MP0000609_abnormal_liver_physiology1.15725731
71MP0005535_abnormal_body_temperature1.13029783
72MP0001664_abnormal_digestion1.12266027
73MP0005584_abnormal_enzyme/coenzyme_acti1.11641335
74MP0004185_abnormal_adipocyte_glucose1.11419870
75MP0005408_hypopigmentation1.10671950
76MP0009379_abnormal_foot_pigmentation1.09669106
77MP0008775_abnormal_heart_ventricle1.08853005
78MP0001905_abnormal_dopamine_level1.05729996
79MP0000427_abnormal_hair_cycle1.04654803
80MP0001873_stomach_inflammation1.03402603
81MP0005319_abnormal_enzyme/_coenzyme1.02693932
82MP0005646_abnormal_pituitary_gland1.01222817
83MP0000383_abnormal_hair_follicle1.01087353
84MP0003638_abnormal_response/metabolism_1.00830608
85MP0005058_abnormal_lysosome_morphology1.00325517
86MP0002277_abnormal_respiratory_mucosa0.99701962
87MP0004134_abnormal_chest_morphology0.98960083
88MP0003186_abnormal_redox_activity0.97547239
89MP0003329_amyloid_beta_deposits0.97351591
90MP0004133_heterotaxia0.96703137
91MP0005671_abnormal_response_to0.96602078
92MP0002837_dystrophic_cardiac_calcinosis0.95661841
93MP0005083_abnormal_biliary_tract0.95650147
94MP0003953_abnormal_hormone_level0.95060395
95MP0004742_abnormal_vestibular_system0.92750858
96MP0009053_abnormal_anal_canal0.92502452
97MP0006036_abnormal_mitochondrial_physio0.92221076
98MP0010678_abnormal_skin_adnexa0.92215675
99MP0009765_abnormal_xenobiotic_induced0.91547870
100MP0000230_abnormal_systemic_arterial0.91312416
101MP0008877_abnormal_DNA_methylation0.91027357
102MP0005448_abnormal_energy_balance0.90707121
103MP0002136_abnormal_kidney_physiology0.88290245
104MP0003936_abnormal_reproductive_system0.88274878
105MP0003191_abnormal_cellular_cholesterol0.88039946
106MP0010234_abnormal_vibrissa_follicle0.86390699
107MP0009697_abnormal_copulation0.85454442
108MP0003938_abnormal_ear_development0.84512160
109MP0000015_abnormal_ear_pigmentation0.84334658
110MP0009250_abnormal_appendicular_skeleto0.83320094
111MP0003119_abnormal_digestive_system0.83009162
112MP0000685_abnormal_immune_system0.82807016
113MP0003567_abnormal_fetal_cardiomyocyte0.82083490
114MP0005195_abnormal_posterior_eye0.81728200
115MP0010094_abnormal_chromosome_stability0.81144759
116MP0002166_altered_tumor_susceptibility0.80059819
117MP0002095_abnormal_skin_pigmentation0.79578355
118MP0003690_abnormal_glial_cell0.79195106
119MP0005410_abnormal_fertilization0.79083206
120MP0003315_abnormal_perineum_morphology0.78581360
121MP0002282_abnormal_trachea_morphology0.77732295
122MP0004147_increased_porphyrin_level0.76606878
123MP0001502_abnormal_circadian_rhythm0.75187706
124MP0002163_abnormal_gland_morphology0.74816695
125MP0000516_abnormal_urinary_system0.74074988
126MP0009642_abnormal_blood_homeostasis0.73939971
127MP0002734_abnormal_mechanical_nocicepti0.71541231
128MP0001661_extended_life_span0.70750224
129MP0006072_abnormal_retinal_apoptosis0.70491637
130MP0001177_atelectasis0.70288877
131MP0000003_abnormal_adipose_tissue0.69865225
132MP0002229_neurodegeneration0.68901183
133MP0005171_absent_coat_pigmentation0.66399911
134MP0001485_abnormal_pinna_reflex0.65867997
135MP0000920_abnormal_myelination0.64151246
136MP0002928_abnormal_bile_duct0.63397951
137MP0000372_irregular_coat_pigmentation0.62929466
138MP0003300_gastrointestinal_ulcer0.60764337
139MP0000604_amyloidosis0.60750137
140MP0002069_abnormal_eating/drinking_beha0.60711207
141MP0004142_abnormal_muscle_tone0.58835171
142MP0003866_abnormal_defecation0.56468217
143MP0005266_abnormal_metabolism0.56101769
144MP0005376_homeostasis/metabolism_phenot0.55759029
145MP0005334_abnormal_fat_pad0.55274580
146MP0002272_abnormal_nervous_system0.53457661
147MP0002896_abnormal_bone_mineralization0.52411019
148MP0000613_abnormal_salivary_gland0.51457373
149MP0003879_abnormal_hair_cell0.51216489
150MP0005645_abnormal_hypothalamus_physiol0.48967925
151MP0000639_abnormal_adrenal_gland0.48325277
152MP0008872_abnormal_physiological_respon0.47905329
153MP0005377_hearing/vestibular/ear_phenot0.47279155
154MP0003878_abnormal_ear_physiology0.47279155
155MP0003959_abnormal_lean_body0.46303004
156MP0005381_digestive/alimentary_phenotyp0.46167665
157MP0001270_distended_abdomen0.45766331

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.61572043
2Hypokalemic alkalosis (HP:0001949)4.45150640
3Hyperactive renin-angiotensin system (HP:0000841)4.40468808
4Hypoglycemic coma (HP:0001325)4.27052347
5Metabolic alkalosis (HP:0200114)4.08236968
6Abnormality of chloride homeostasis (HP:0011422)4.05801926
7Intrahepatic cholestasis (HP:0001406)3.99963107
8Hypoglycemic seizures (HP:0002173)3.98476478
9Ketoacidosis (HP:0001993)3.97489861
10Hyperinsulinemic hypoglycemia (HP:0000825)3.93994656
11Conjugated hyperbilirubinemia (HP:0002908)3.92989610
12Abnormality of glutamine family amino acid metabolism (HP:0010902)3.91573835
13Symptomatic seizures (HP:0011145)3.87000181
14Gout (HP:0001997)3.86447809
15Increased circulating renin level (HP:0000848)3.79429771
16Methylmalonic acidemia (HP:0002912)3.76226108
17Hyperglycinuria (HP:0003108)3.70242156
18Cutaneous melanoma (HP:0012056)3.58634918
19Alkalosis (HP:0001948)3.53719795
20Generalized aminoaciduria (HP:0002909)3.45558108
21Abnormality of the proximal phalanges of the hand (HP:0009834)3.43941894
22Hypomagnesemia (HP:0002917)3.40797841
23Hypobetalipoproteinemia (HP:0003563)3.39331253
24Methylmalonic aciduria (HP:0012120)3.35503654
25Ketosis (HP:0001946)3.29427374
26Abnormality of glycine metabolism (HP:0010895)3.21362498
27Abnormality of serine family amino acid metabolism (HP:0010894)3.21362498
28Abnormality of purine metabolism (HP:0004352)3.20765210
29Abnormal urine output (HP:0012590)3.20462925
30Hyperaldosteronism (HP:0000859)3.20358872
31Abnormality of urine glucose concentration (HP:0011016)3.16180463
32Glycosuria (HP:0003076)3.16180463
33Abnormality of magnesium homeostasis (HP:0004921)3.15236402
34Conjunctival hamartoma (HP:0100780)3.13354916
35Abnormality of monocarboxylic acid metabolism (HP:0010996)3.11610954
36Congenital, generalized hypertrichosis (HP:0004540)3.11179989
37Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.08954265
38Short 1st metacarpal (HP:0010034)3.08954265
39Polyuria (HP:0000103)3.07751138
40Hypoplasia of the uterus (HP:0000013)3.04967697
41Xanthomatosis (HP:0000991)3.03926042
42Abnormality of renin-angiotensin system (HP:0000847)3.02670169
43Abnormality of renal excretion (HP:0011036)3.01660031
44Proximal tubulopathy (HP:0000114)3.01540366
45Fat malabsorption (HP:0002630)3.01424755
46Renal salt wasting (HP:0000127)2.99824105
47Meningioma (HP:0002858)2.99364737
48Pendular nystagmus (HP:0012043)2.97927476
49Pheochromocytoma (HP:0002666)2.94302734
50Hypokalemia (HP:0002900)2.92149288
51Congenital sensorineural hearing impairment (HP:0008527)2.87276941
52Pancreatic cysts (HP:0001737)2.85820512
53Abnormality of fatty-acid metabolism (HP:0004359)2.84882103
54Acute necrotizing encephalopathy (HP:0006965)2.81883322
55Type II lissencephaly (HP:0007260)2.81835231
56Congenital stationary night blindness (HP:0007642)2.79641757
57Abnormality of the 1st metacarpal (HP:0010009)2.79174066
58Absent thumb (HP:0009777)2.79063256
59Abnormality of vitamin B metabolism (HP:0004340)2.79004554
60Abnormality of the vitamin B12 metabolism (HP:0004341)2.76802512
61Abnormality of aspartate family amino acid metabolism (HP:0010899)2.72973081
62Ileus (HP:0002595)2.69774521
63Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.69167219
64Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.63069598
65Abnormality of alanine metabolism (HP:0010916)2.63069598
66Hyperalaninemia (HP:0003348)2.63069598
67Hydroxyprolinuria (HP:0003080)2.62277006
68Abnormality of proline metabolism (HP:0010907)2.62277006
69Mitochondrial inheritance (HP:0001427)2.61531152
70Aplasia/hypoplasia of the uterus (HP:0008684)2.61523571
71Increased purine levels (HP:0004368)2.61160406
72Hyperuricemia (HP:0002149)2.61160406
73Abnormality of the renal cortex (HP:0011035)2.60791880
74Decreased subcutaneous fat (HP:0001002)2.60620644
75Hyperglycinemia (HP:0002154)2.60441906
76Abnormal mitochondria in muscle tissue (HP:0008316)2.58722735
77Late onset (HP:0003584)2.58652296
78Hyperammonemia (HP:0001987)2.58114863
79Hypoplasia of the pons (HP:0012110)2.57771362
80Abolished electroretinogram (ERG) (HP:0000550)2.53577408
81Hyperphosphaturia (HP:0003109)2.53218344
82Hamartoma of the eye (HP:0010568)2.52461325
83Malnutrition (HP:0004395)2.52096662
84Metabolic acidosis (HP:0001942)2.52014963
85Progressive macrocephaly (HP:0004481)2.51088441
86Increased CSF lactate (HP:0002490)2.48975076
87Neuroendocrine neoplasm (HP:0100634)2.46929532
88Abnormality of nucleobase metabolism (HP:0010932)2.46503823
89Renal cortical cysts (HP:0000803)2.45989728
90Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.45776834
91Abnormality of the pons (HP:0007361)2.43779230
92Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.43709834
93Irritability (HP:0000737)2.43410972
94Hyperglycemia (HP:0003074)2.40318886
95Pancreatic fibrosis (HP:0100732)2.38816230
96Abnormality of calcium-phosphate metabolism (HP:0100530)2.37627937
97Abnormality of sulfur amino acid metabolism (HP:0004339)2.37528991
98Concave nail (HP:0001598)2.36936419
99Abnormality of the renal collecting system (HP:0004742)2.36718920
100Abnormality of the middle phalanges of the toes (HP:0010183)2.36193567
101Lethargy (HP:0001254)2.35466226
102Chorioretinal atrophy (HP:0000533)2.34920842
103Abnormality of midbrain morphology (HP:0002418)2.34418597
104Molar tooth sign on MRI (HP:0002419)2.34418597
105Abnormality of the intrinsic pathway (HP:0010989)2.34334631
106Abnormality of DNA repair (HP:0003254)2.33878291
107Abnormality of potassium homeostasis (HP:0011042)2.33254171
108Acute encephalopathy (HP:0006846)2.32802036
109Widely patent fontanelles and sutures (HP:0004492)2.31865681
1103-Methylglutaconic aciduria (HP:0003535)2.30604148
111Furrowed tongue (HP:0000221)2.29118211
112Polydipsia (HP:0001959)2.28795484
113Abnormal drinking behavior (HP:0030082)2.28795484
114Confusion (HP:0001289)2.28681709
115Nephronophthisis (HP:0000090)2.28268826
116Stenosis of the external auditory canal (HP:0000402)2.28053720
117Abnormality of the nasal septum (HP:0000419)2.27233447
118True hermaphroditism (HP:0010459)2.27137777
119Symphalangism affecting the phalanges of the hand (HP:0009773)2.25372618
120Prolonged partial thromboplastin time (HP:0003645)2.24612585
121Abnormality of subcutaneous fat tissue (HP:0001001)2.24396587
122Abnormality of the phalanges of the 5th finger (HP:0004213)2.22496235
123Dicarboxylic aciduria (HP:0003215)2.21230506
124Abnormality of dicarboxylic acid metabolism (HP:0010995)2.21230506
125Abnormal number of erythroid precursors (HP:0012131)2.17556560
126IgG deficiency (HP:0004315)2.16877912
127Hypophosphatemia (HP:0002148)2.16870723
128Decreased circulating renin level (HP:0003351)2.16690351
129Cerebral edema (HP:0002181)2.16125760
130Hypolipoproteinemia (HP:0010981)2.16057540
131Abnormal urine phosphate concentration (HP:0012599)2.15590764
132Lipid accumulation in hepatocytes (HP:0006561)2.14982753
133Vomiting (HP:0002013)2.13867833
134Short hallux (HP:0010109)2.13384221
135Decreased electroretinogram (ERG) amplitude (HP:0000654)2.12988427
136Hepatocellular necrosis (HP:0001404)2.11902270
137Short femoral neck (HP:0100864)2.11504334
138Short phalanx of the thumb (HP:0009660)2.10444667
139Tetany (HP:0001281)2.07688086
140Abnormality of endocrine pancreas physiology (HP:0012093)2.06834802
141Abnormality of the pancreatic islet cells (HP:0006476)2.06834802
142Abnormality of cells of the erythroid lineage (HP:0012130)2.06677563
143Abnormality of serum amino acid levels (HP:0003112)2.05686090
144Aplasia/Hypoplasia of the hallux (HP:0008362)2.04399960
145Epidermoid cyst (HP:0200040)2.04018716
146Severe muscular hypotonia (HP:0006829)2.03981842
147Bone cyst (HP:0012062)2.01018123
148Hyperbilirubinemia (HP:0002904)2.00021193
149Abnormality of the renal medulla (HP:0100957)1.99716641
150Asplenia (HP:0001746)1.98933703
151Abnormal enzyme/coenzyme activity (HP:0012379)1.97342499
152Increased hepatocellular lipid droplets (HP:0006565)1.96910651
153Adrenal overactivity (HP:0002717)1.96890160
154Rickets (HP:0002748)1.96696851
155Osteomalacia (HP:0002749)1.96444963
156Acanthocytosis (HP:0001927)1.96311898
157Abnormality of the phalanges of the 2nd finger (HP:0009541)1.96005876
158Abnormality of vitamin metabolism (HP:0100508)1.95465241
159Nephrolithiasis (HP:0000787)1.95414398
160Aplasia/Hypoplasia of the uvula (HP:0010293)1.94940341
161Aplasia/Hypoplasia of the spleen (HP:0010451)1.94445629
162Hypothermia (HP:0002045)1.94105174
163Potter facies (HP:0002009)1.93673696
164Facial shape deformation (HP:0011334)1.93673696
165Pancreatic islet-cell hyperplasia (HP:0004510)1.93225246
166Abnormality of alkaline phosphatase activity (HP:0004379)1.92031103
167Hepatic necrosis (HP:0002605)1.91893376
168Pancreatitis (HP:0001733)1.91557921
169Melanoma (HP:0002861)1.91338269
170Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.91277343
171Dehydration (HP:0001944)1.90918866
172Enlarged kidneys (HP:0000105)1.90344142
173Abnormality of the common coagulation pathway (HP:0010990)1.89965177
174Increased corneal curvature (HP:0100692)1.89293031
175Keratoconus (HP:0000563)1.89293031
176Sensorimotor neuropathy (HP:0007141)1.88385853
177Vascular calcification (HP:0004934)1.87990937
178Increased serum lactate (HP:0002151)1.86747255
179Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.85724332
180Goiter (HP:0000853)1.85649726
181Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85598928
182Short tibia (HP:0005736)1.83225135
183Lactic acidosis (HP:0003128)1.83152267
184Aplasia/Hypoplasia of the tibia (HP:0005772)1.83133883

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK44.57196117
2WNK34.40652799
3OXSR14.08967500
4TLK13.65061310
5INSRR3.62652897
6FRK3.60581299
7ZAK3.58690604
8ADRBK23.24488625
9AKT33.18075747
10STK393.03577075
11BCKDK2.77500551
12MAPK152.66034494
13MST42.47420172
14ACVR1B2.44980528
15LMTK22.42269498
16MET2.02483616
17MAPKAPK31.99310465
18NUAK11.96919965
19MAP3K21.93441410
20MST1R1.83124606
21BCR1.80579682
22MAP4K21.80118026
23CASK1.79685472
24SGK4941.78379764
25SGK2231.78379764
26NME11.67526179
27TXK1.62238689
28STK38L1.58383168
29BUB11.52220594
30PASK1.46401287
31VRK21.43338338
32ERBB41.42938608
33IRAK31.41439464
34PRKG21.40172113
35VRK11.35856740
36IKBKB1.30110276
37WNK11.28178970
38BRAF1.24373523
39BRSK21.24051781
40IRAK21.23130350
41PRKD31.22882991
42NTRK11.22352097
43TAF11.20948179
44ERN11.19110981
45MAP2K71.15029244
46MAP2K21.13840288
47PRPF4B1.13743155
48SGK21.11780959
49ARAF1.10909844
50EIF2AK11.10877093
51EPHA21.10616869
52CSNK1G31.08814596
53PAK31.03422301
54CAMK2G1.02934133
55MAPK131.02462951
56GRK70.95938403
57PDK20.94918718
58FER0.91282530
59CAMK2D0.91136221
60TAOK30.90925452
61GSK3A0.89258631
62RPS6KA50.89170911
63PDK40.88455613
64PDK30.88455613
65HIPK20.88000425
66MAP3K40.86796338
67SGK30.86756371
68CSNK1G20.86208403
69WEE10.85139127
70PLK40.84313346
71PLK20.83938986
72NEK20.83867757
73ADRBK10.83778045
74AURKA0.82889958
75CAMK2B0.82523005
76PTK20.81918456
77LIMK10.80075422
78EPHB10.79301420
79PRKCE0.79051547
80PINK10.78620654
81PRKD20.78615827
82NEK60.76808739
83CSNK1A1L0.76724629
84ATR0.74950674
85CDK80.74649473
86CDK90.74165051
87CDC70.72987564
88PBK0.72451323
89NEK90.71860696
90DYRK1B0.68634574
91PRKCI0.67941339
92BMPR20.67861750
93MUSK0.67840022
94PLK10.65977031
95NTRK30.65962433
96EIF2AK20.65957386
97FGFR20.63152690
98NEK10.63007595
99DAPK20.62399492
100PHKG20.60784131
101PHKG10.60784131
102EIF2AK30.60038823
103SRPK10.57727131
104TIE10.57539259
105CSNK1A10.56205097
106FLT30.56168599
107MAP2K60.56032400
108CHEK20.54953017
109DYRK20.54835538
110STK160.54567885
111TESK10.53607040
112UHMK10.53596664
113PLK30.52923910
114CSNK2A10.50793470
115TEC0.50764469
116PIM10.50641727
117PRKCH0.50368543
118PRKAA10.49956491
119CHUK0.48981225
120NME20.48644241
121IRAK10.47220737
122TRIM280.46275780
123TGFBR10.46074311
124MAP3K30.45401895
125CAMK2A0.45250720
126RPS6KB20.44553964
127PDPK10.44255603
128CDC42BPA0.43615867
129MAP2K10.43203701
130PIK3CA0.42302469
131PTK60.42119570
132PIK3CG0.42014302
133ABL20.41801813
134CCNB10.41713511
135MAPK110.41426765
136PRKACA0.41276708
137MAP3K10.40929958
138PRKCQ0.40751642
139CAMKK20.40423754
140ERBB30.40380254
141RPS6KB10.39872173
142PRKACG0.39673328
143GRK50.39574782
144CDK50.38713859
145PRKCA0.37979430
146FGFR40.37825676
147GRK10.36522654
148MAP3K140.34461426
149BMPR1B0.33123842
150PRKCG0.31289336
151MAPKAPK50.30236101
152MYLK0.29680190
153DYRK1A0.29239462
154SGK10.28703732
155CSNK1G10.28278532
156PRKCZ0.28119814
157YES10.26300882
158PRKAA20.25608880
159TESK20.25323049
160SCYL20.24891310
161IGF1R0.24642379
162GRK60.24428774

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.96859784
2* Sulfur metabolism_Homo sapiens_hsa009202.48004536
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.43585371
4Butanoate metabolism_Homo sapiens_hsa006502.39695452
5Ribosome_Homo sapiens_hsa030102.33948962
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.29292449
7Tryptophan metabolism_Homo sapiens_hsa003802.17049894
8Folate biosynthesis_Homo sapiens_hsa007902.10882922
9Protein export_Homo sapiens_hsa030602.06905072
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.03449711
11Fat digestion and absorption_Homo sapiens_hsa049752.01583427
12Homologous recombination_Homo sapiens_hsa034401.99240123
13Nitrogen metabolism_Homo sapiens_hsa009101.99118638
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.99058587
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.98498953
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.96818480
17Fatty acid degradation_Homo sapiens_hsa000711.94433884
18Histidine metabolism_Homo sapiens_hsa003401.89470102
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.89132151
20Propanoate metabolism_Homo sapiens_hsa006401.87822869
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.85644675
22Vitamin digestion and absorption_Homo sapiens_hsa049771.81430398
23Sulfur relay system_Homo sapiens_hsa041221.81254846
24Peroxisome_Homo sapiens_hsa041461.77987409
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.77516798
26Fatty acid elongation_Homo sapiens_hsa000621.76667608
27Steroid biosynthesis_Homo sapiens_hsa001001.71993973
28Fanconi anemia pathway_Homo sapiens_hsa034601.70780943
29Starch and sucrose metabolism_Homo sapiens_hsa005001.68527818
30Pyruvate metabolism_Homo sapiens_hsa006201.67922263
31Proteasome_Homo sapiens_hsa030501.67295124
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.67175687
33RNA polymerase_Homo sapiens_hsa030201.67154097
34One carbon pool by folate_Homo sapiens_hsa006701.65713563
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.63579389
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.61607815
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56900191
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.52629594
39Fatty acid metabolism_Homo sapiens_hsa012121.52376602
40Arginine biosynthesis_Homo sapiens_hsa002201.50003377
41Basal transcription factors_Homo sapiens_hsa030221.49786991
42Nucleotide excision repair_Homo sapiens_hsa034201.49619903
43Phototransduction_Homo sapiens_hsa047441.46319693
44Mineral absorption_Homo sapiens_hsa049781.38533939
45beta-Alanine metabolism_Homo sapiens_hsa004101.37794327
46Bile secretion_Homo sapiens_hsa049761.36803217
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36645587
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.33543065
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.28891617
50Intestinal immune network for IgA production_Homo sapiens_hsa046721.28684856
51Huntingtons disease_Homo sapiens_hsa050161.28123262
52RNA degradation_Homo sapiens_hsa030181.27654421
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.27470113
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.27283362
55Collecting duct acid secretion_Homo sapiens_hsa049661.26947444
56Arginine and proline metabolism_Homo sapiens_hsa003301.26137241
57Selenocompound metabolism_Homo sapiens_hsa004501.25490218
58Galactose metabolism_Homo sapiens_hsa000521.24141371
59Vibrio cholerae infection_Homo sapiens_hsa051101.23458635
60Phenylalanine metabolism_Homo sapiens_hsa003601.21755527
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21467468
62Cyanoamino acid metabolism_Homo sapiens_hsa004601.20649727
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.20034063
64Chemical carcinogenesis_Homo sapiens_hsa052041.16731516
65DNA replication_Homo sapiens_hsa030301.14732676
66PPAR signaling pathway_Homo sapiens_hsa033201.14688568
67Glutathione metabolism_Homo sapiens_hsa004801.12816947
68Pyrimidine metabolism_Homo sapiens_hsa002401.09683738
69Carbohydrate digestion and absorption_Homo sapiens_hsa049731.09543955
70Steroid hormone biosynthesis_Homo sapiens_hsa001401.07411081
71Oxidative phosphorylation_Homo sapiens_hsa001901.05473816
72Renin-angiotensin system_Homo sapiens_hsa046141.04057970
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03885053
74Carbon metabolism_Homo sapiens_hsa012001.02860484
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02694931
76Tyrosine metabolism_Homo sapiens_hsa003501.01179964
77Fructose and mannose metabolism_Homo sapiens_hsa000510.98990704
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96786992
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.96422761
80Retinol metabolism_Homo sapiens_hsa008300.95466753
81ABC transporters_Homo sapiens_hsa020100.95330360
82Systemic lupus erythematosus_Homo sapiens_hsa053220.94353808
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94104234
84Primary immunodeficiency_Homo sapiens_hsa053400.92959108
85Mismatch repair_Homo sapiens_hsa034300.91136297
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89322994
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86373021
88Glycerolipid metabolism_Homo sapiens_hsa005610.86190966
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85367987
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82865447
91Insulin secretion_Homo sapiens_hsa049110.82028382
92Cardiac muscle contraction_Homo sapiens_hsa042600.81747173
93Purine metabolism_Homo sapiens_hsa002300.80862001
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78337719
95Caffeine metabolism_Homo sapiens_hsa002320.78237044
96Protein digestion and absorption_Homo sapiens_hsa049740.70551326
97Sphingolipid metabolism_Homo sapiens_hsa006000.70035579
98Biosynthesis of amino acids_Homo sapiens_hsa012300.68210039
99* Metabolic pathways_Homo sapiens_hsa011000.67322777
100Base excision repair_Homo sapiens_hsa034100.65870063
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.64960620
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62841608
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62797955
104N-Glycan biosynthesis_Homo sapiens_hsa005100.60784553
105Fatty acid biosynthesis_Homo sapiens_hsa000610.60013619
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59381330
107Parkinsons disease_Homo sapiens_hsa050120.59230869
108Nicotine addiction_Homo sapiens_hsa050330.58451854
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57463199
110Vitamin B6 metabolism_Homo sapiens_hsa007500.55909722
111Other glycan degradation_Homo sapiens_hsa005110.55238829
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53326204
113Synaptic vesicle cycle_Homo sapiens_hsa047210.52300343
114Complement and coagulation cascades_Homo sapiens_hsa046100.52066597
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51241327
116Asthma_Homo sapiens_hsa053100.50037030
117Thyroid hormone synthesis_Homo sapiens_hsa049180.48127332
118Alzheimers disease_Homo sapiens_hsa050100.47880517
119Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47232323
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47133018
121Linoleic acid metabolism_Homo sapiens_hsa005910.46933290
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45307560
123Lysosome_Homo sapiens_hsa041420.41799388
124Ether lipid metabolism_Homo sapiens_hsa005650.39760207
125Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37922211
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37593671
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35530381
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.34764144
129Taste transduction_Homo sapiens_hsa047420.34540691
130Pancreatic secretion_Homo sapiens_hsa049720.33689559
131p53 signaling pathway_Homo sapiens_hsa041150.33425260
132Pentose phosphate pathway_Homo sapiens_hsa000300.33291310
133Regulation of autophagy_Homo sapiens_hsa041400.33063508
134Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.31494680
135Arachidonic acid metabolism_Homo sapiens_hsa005900.30698817
136Cocaine addiction_Homo sapiens_hsa050300.28078791

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