BPTF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron remodeling (GO:0016322)5.97726720
2regulation of pigment cell differentiation (GO:0050932)5.83211404
3mitotic sister chromatid cohesion (GO:0007064)5.12364130
4nuclear pore complex assembly (GO:0051292)5.06407296
5pre-miRNA processing (GO:0031054)4.72187144
6nuclear pore organization (GO:0006999)4.69750062
7intestinal epithelial cell development (GO:0060576)4.26108937
8developmental pigmentation (GO:0048066)4.22864595
9negative regulation of histone methylation (GO:0031061)4.19580486
10regulation of alternative mRNA splicing, via spliceosome (GO:0000381)4.12833661
11inner ear receptor cell development (GO:0060119)4.05326966
12myelin assembly (GO:0032288)4.03611534
13histone H3-K4 trimethylation (GO:0080182)4.01681403
14phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.00655922
15regulation of RNA export from nucleus (GO:0046831)3.95756277
16negative regulation of striated muscle cell apoptotic process (GO:0010664)3.85420120
17cytoplasmic mRNA processing body assembly (GO:0033962)3.83224600
18histone H3-K4 methylation (GO:0051568)3.81271710
19maternal behavior (GO:0042711)3.79587953
20positive regulation of macroautophagy (GO:0016239)3.75083193
21parental behavior (GO:0060746)3.72937419
22pore complex assembly (GO:0046931)3.70861149
23spinal cord motor neuron differentiation (GO:0021522)3.70852329
24positive regulation of skeletal muscle tissue development (GO:0048643)3.66426499
25regulation of histone H3-K9 methylation (GO:0051570)3.65491733
26coenzyme A metabolic process (GO:0015936)3.49757648
27Sertoli cell development (GO:0060009)3.43428218
28forebrain neuron differentiation (GO:0021879)3.42186515
29peptidyl-lysine trimethylation (GO:0018023)3.38566328
30kidney morphogenesis (GO:0060993)3.35327592
31positive regulation of neurological system process (GO:0031646)3.33060586
32neuron maturation (GO:0042551)3.31959272
33ubiquinone metabolic process (GO:0006743)3.26200413
34regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.25524893
35positive regulation of muscle cell apoptotic process (GO:0010661)3.24509290
36histone lysine methylation (GO:0034968)3.22415124
37negative regulation of NF-kappaB import into nucleus (GO:0042347)3.22141700
38positive regulation of gene expression, epigenetic (GO:0045815)3.21863790
39regulation of DNA endoreduplication (GO:0032875)3.21219624
40regulation of nucleobase-containing compound transport (GO:0032239)3.21141737
41histone H3-K9 methylation (GO:0051567)3.21038149
42establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.20265435
43mitochondrion transport along microtubule (GO:0047497)3.20265435
44regulation of cardiac muscle cell apoptotic process (GO:0010665)3.19168060
45regulation of translation, ncRNA-mediated (GO:0045974)3.17074007
46negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.17074007
47negative regulation of translation, ncRNA-mediated (GO:0040033)3.17074007
48mitotic chromosome condensation (GO:0007076)3.16186239
49negative regulation of glial cell proliferation (GO:0060253)3.13321440
50alternative mRNA splicing, via spliceosome (GO:0000380)3.11925996
51forebrain neuron development (GO:0021884)3.09953279
52heterochromatin organization (GO:0070828)3.07913384
53regulation of mRNA splicing, via spliceosome (GO:0048024)3.04936695
54kinetochore organization (GO:0051383)3.02414853
55regulation of developmental pigmentation (GO:0048070)3.02361387
56regulation of sister chromatid cohesion (GO:0007063)3.01446215
57positive regulation of mitotic sister chromatid separation (GO:1901970)2.99270050
58positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.99270050
59positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.99270050
60histone H2A monoubiquitination (GO:0035518)2.96737193
61interkinetic nuclear migration (GO:0022027)2.96163805
62establishment of nucleus localization (GO:0040023)2.94197279
63regulation of histone H3-K4 methylation (GO:0051569)2.93573355
64sister chromatid cohesion (GO:0007062)2.93321265
65regulation of histone methylation (GO:0031060)2.92615762
66histone lysine demethylation (GO:0070076)2.90451468
67microtubule anchoring (GO:0034453)2.90182136
68gene silencing by RNA (GO:0031047)2.90019357
69mRNA splice site selection (GO:0006376)2.89595878
70glucocorticoid receptor signaling pathway (GO:0042921)2.89519650
71sister chromatid segregation (GO:0000819)2.88457525
72establishment of integrated proviral latency (GO:0075713)2.88106472
73histone methylation (GO:0016571)2.87920763
74histone H3-K9 modification (GO:0061647)2.87188309
75histone H3-K9 demethylation (GO:0033169)2.86733911
76negative regulation of histone modification (GO:0031057)2.86552044
77histone H3-K36 demethylation (GO:0070544)2.86463818
78negative regulation of chromatin modification (GO:1903309)2.84837905
79establishment of mitochondrion localization (GO:0051654)2.83894276
80DNA alkylation (GO:0006305)2.83436529
81DNA methylation (GO:0006306)2.83436529
82histone demethylation (GO:0016577)2.83006985
83monoubiquitinated protein deubiquitination (GO:0035520)2.80670622
84histone H4-K16 acetylation (GO:0043984)2.78871184
85chromatin remodeling at centromere (GO:0031055)2.78157494
86mitotic nuclear envelope disassembly (GO:0007077)2.77723858
87regulation of posttranscriptional gene silencing (GO:0060147)2.77592230
88regulation of gene silencing by miRNA (GO:0060964)2.77592230
89regulation of gene silencing by RNA (GO:0060966)2.77592230
90regulation of mitotic spindle organization (GO:0060236)2.77555452
91DNA unwinding involved in DNA replication (GO:0006268)2.75542958
92paraxial mesoderm development (GO:0048339)2.74292188
93nucleus localization (GO:0051647)2.74146390
94positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.73840529
95regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.73840529
96peptidyl-lysine methylation (GO:0018022)2.71406904
97regulation of spindle organization (GO:0090224)2.70621177
98NLS-bearing protein import into nucleus (GO:0006607)2.69263608
99histone H4-K12 acetylation (GO:0043983)2.69148687
100negative regulation of DNA-dependent DNA replication (GO:2000104)2.68618718
101positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.68323311
102regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.68323311
103DNA duplex unwinding (GO:0032508)2.67233802
104DNA geometric change (GO:0032392)2.66485774
105DNA double-strand break processing (GO:0000729)2.66086383
106positive regulation of response to extracellular stimulus (GO:0032106)2.65205291
107positive regulation of response to nutrient levels (GO:0032109)2.65205291
108stress granule assembly (GO:0034063)2.64950291
109gene silencing (GO:0016458)2.64547674
110regulation of protein polyubiquitination (GO:1902914)2.63540605
111membrane disassembly (GO:0030397)2.63362625
112nuclear envelope disassembly (GO:0051081)2.63362625
113presynaptic membrane assembly (GO:0097105)2.62493453
114CENP-A containing nucleosome assembly (GO:0034080)2.61749755
115dosage compensation (GO:0007549)2.61413173
116protein localization to kinetochore (GO:0034501)2.60971322
117positive regulation of histone H3-K4 methylation (GO:0051571)2.60955093
118chromatin assembly (GO:0031497)2.58947815
119positive regulation of chromosome segregation (GO:0051984)2.58456794
120negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.57752496
121phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.55952516
122pyrimidine nucleobase catabolic process (GO:0006208)2.55550848
123histone H4 acetylation (GO:0043967)2.55163666
124kinetochore assembly (GO:0051382)2.54672045
125negative regulation of DNA repair (GO:0045738)2.53566960
126regulation of striated muscle cell apoptotic process (GO:0010662)2.53390586
127postreplication repair (GO:0006301)2.51211796
128cell differentiation in spinal cord (GO:0021515)2.50849124
129myoblast differentiation (GO:0045445)2.50641867
130corticosteroid receptor signaling pathway (GO:0031958)2.50498016
131RNA stabilization (GO:0043489)2.50112142
132mRNA stabilization (GO:0048255)2.50112142
133protein dealkylation (GO:0008214)2.49874999
134protein demethylation (GO:0006482)2.49874999
135regulation of centriole replication (GO:0046599)2.49690984
136inner cell mass cell proliferation (GO:0001833)2.49299781
137spermatid nucleus differentiation (GO:0007289)2.49241873
138mitotic sister chromatid segregation (GO:0000070)2.48864788
139regulation of gene expression by genetic imprinting (GO:0006349)2.46981652
140prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.46560263
141acrosome reaction (GO:0007340)2.45566728
142histone H4-K5 acetylation (GO:0043981)2.44992326
143histone H4-K8 acetylation (GO:0043982)2.44992326
144regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.43830384
145regulation of non-canonical Wnt signaling pathway (GO:2000050)2.43473476
146DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.43065659
147TOR signaling (GO:0031929)2.42652151
148DNA methylation or demethylation (GO:0044728)2.42169926
149histone exchange (GO:0043486)2.41546778
150meiotic chromosome segregation (GO:0045132)2.41317220
151histone mRNA catabolic process (GO:0071044)2.40457671
152limb bud formation (GO:0060174)2.40192245
153protein-DNA complex disassembly (GO:0032986)2.39823137
154nucleosome disassembly (GO:0006337)2.39823137
155startle response (GO:0001964)2.39273969
156cerebral cortex development (GO:0021987)2.38178724
157regulation of chromatin silencing (GO:0031935)2.38089173
158embryonic hindlimb morphogenesis (GO:0035116)2.37054273
159histone acetylation (GO:0016573)2.37016628
160negative regulation of RNA splicing (GO:0033119)2.36962641
161peptidyl-lysine dimethylation (GO:0018027)2.36727288
162hindlimb morphogenesis (GO:0035137)2.35812330
163positive regulation of mitochondrial membrane permeability (GO:0035794)2.35191124
164metaphase plate congression (GO:0051310)2.34925061
165positive regulation of mRNA 3-end processing (GO:0031442)2.34542139
166positive regulation of mRNA catabolic process (GO:0061014)2.34363600
167regulation of mRNA processing (GO:0050684)2.33992611
168regulation of glial cell proliferation (GO:0060251)2.32750747
169neurotransmitter-gated ion channel clustering (GO:0072578)2.30049249
170mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.29760172
171positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.29760172
172left/right axis specification (GO:0070986)2.29667103
173presynaptic membrane organization (GO:0097090)2.28330612

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.14281517
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.10322934
3SALL1_21062744_ChIP-ChIP_HESCs_Human4.09156897
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.96469069
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.64791147
6EZH2_22144423_ChIP-Seq_EOC_Human3.44995300
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.27550630
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.27268931
9TP63_19390658_ChIP-ChIP_HaCaT_Human3.22264010
10GBX2_23144817_ChIP-Seq_PC3_Human2.85377785
11MYC_22102868_ChIP-Seq_BL_Human2.81434613
12VDR_22108803_ChIP-Seq_LS180_Human2.58740449
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.45279641
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.44895094
15POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.40423596
16ZNF274_21170338_ChIP-Seq_K562_Hela2.34011329
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.31188797
18TAF15_26573619_Chip-Seq_HEK293_Human2.28717359
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.28310340
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.21444008
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.20952927
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.15325195
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10817816
24STAT6_21828071_ChIP-Seq_BEAS2B_Human2.07082969
25E2F1_21310950_ChIP-Seq_MCF-7_Human2.02215133
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96144031
27SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.93649187
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.90165300
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.89353686
30HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.88548584
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87277874
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.87214595
33* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.85783931
34FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.81508604
35CIITA_25753668_ChIP-Seq_RAJI_Human1.81494340
36P300_19829295_ChIP-Seq_ESCs_Human1.80827217
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80691307
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79521501
39ER_23166858_ChIP-Seq_MCF-7_Human1.76563726
40TCF7_22412390_ChIP-Seq_EML_Mouse1.71043305
41PKCTHETA_26484144_Chip-Seq_BREAST_Human1.69453261
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65074848
43SMAD4_21799915_ChIP-Seq_A2780_Human1.64826831
44BCAT_22108803_ChIP-Seq_LS180_Human1.62741707
45IGF1R_20145208_ChIP-Seq_DFB_Human1.61668225
46SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.61505074
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60644985
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.60004131
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.59059985
50* TCF4_23295773_ChIP-Seq_U87_Human1.57668288
51ZFP281_27345836_Chip-Seq_ESCs_Mouse1.53831612
52* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52790881
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.48563944
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48005942
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47293008
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.46867084
57* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.46519713
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46433375
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45150076
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.44376300
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.42107531
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.40624696
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.39642594
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38275358
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37837399
66KDM2B_26808549_Chip-Seq_DND41_Human1.37600581
67STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.36131798
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34471892
69CBP_20019798_ChIP-Seq_JUKART_Human1.34471892
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34446665
71TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32803316
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31971175
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28990989
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27413009
75AR_21909140_ChIP-Seq_LNCAP_Human1.27367839
76* FLI1_21867929_ChIP-Seq_TH2_Mouse1.26380497
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26168423
78FUS_26573619_Chip-Seq_HEK293_Human1.26029532
79ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.25831466
80AR_25329375_ChIP-Seq_VCAP_Human1.25613788
81FLI1_27457419_Chip-Seq_LIVER_Mouse1.24840768
82KDM2B_26808549_Chip-Seq_JURKAT_Human1.24761329
83ISL1_27105846_Chip-Seq_CPCs_Mouse1.23905755
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21129568
85TP53_16413492_ChIP-PET_HCT116_Human1.20452748
86EWS_26573619_Chip-Seq_HEK293_Human1.20024016
87EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19144478
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18448366
89SOX9_26525672_Chip-Seq_HEART_Mouse1.17469835
90STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.17426746
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17371681
92LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16398538
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15859895
94TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14834635
95SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.14398876
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14385422
97FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13934935
98VDR_21846776_ChIP-Seq_THP-1_Human1.13244135
99KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13115663
100TBX3_20139965_ChIP-Seq_ESCs_Mouse1.13036565
101TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12669012
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12153018
103TBX3_20139965_ChIP-Seq_MESCs_Mouse1.12071172
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11073687
105CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10789961
106BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10605111
107* GF1B_26923725_Chip-Seq_HPCs_Mouse1.10530563
108POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.09663720
109RUNX2_22187159_ChIP-Seq_PCA_Human1.09157654
110SMAD3_21741376_ChIP-Seq_ESCs_Human1.09025047
111TCF4_22108803_ChIP-Seq_LS180_Human1.08930627
112UTX_26944678_Chip-Seq_JUKART_Human1.08236505
113SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07892933
114VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06540507
115CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06509835
116NANOG_18555785_Chip-Seq_ESCs_Mouse1.06473105
117DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06256104
118ARNT_22903824_ChIP-Seq_MCF-7_Human1.06248990
119RNF2_27304074_Chip-Seq_NSC_Mouse1.06113261
120FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05787678
121EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03714090
122SOX2_21211035_ChIP-Seq_LN229_Gbm1.03581384
123TCF4_18268006_ChIP-ChIP_LS174T_Human1.03381363
124KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.02939159
125KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.02939159
126KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.02939159
127BRD4_25478319_ChIP-Seq_HGPS_Human1.02901442
128JUN_21703547_ChIP-Seq_K562_Human1.02398438
129EZH2_27294783_Chip-Seq_NPCs_Mouse1.02194187
130CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02187749
131ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01284247
132CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00962409
133AR_21572438_ChIP-Seq_LNCaP_Human1.00367534
134MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00351817
135NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.00193851
136TCF3_18692474_ChIP-Seq_MESCs_Mouse1.00169767
137PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98919129
138SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98685457
139KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98585059
140MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98431941
141SMAD4_21741376_ChIP-Seq_EPCs_Human0.97460281
142NANOG_21062744_ChIP-ChIP_HESCs_Human0.97379836
143E2F1_18555785_Chip-Seq_ESCs_Mouse0.97152016
144EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97062844
145CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96921493
146REST_21632747_ChIP-Seq_MESCs_Mouse0.96624501
147SCL_19346495_ChIP-Seq_HPC-7_Human0.95506345
148EZH2_27304074_Chip-Seq_ESCs_Mouse0.95148433
149MYB_26560356_Chip-Seq_TH1_Human0.94795264
150TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.93903646
151NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92708918
152KDM5A_27292631_Chip-Seq_BREAST_Human0.91784938
153RUNX_20019798_ChIP-Seq_JUKART_Human0.91495958
154RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90923540
155CHD1_26751641_Chip-Seq_LNCaP_Human0.89838668
156POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89325311
157* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.89320572
158* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88272966
159NOTCH1_21737748_ChIP-Seq_TLL_Human0.86314773
160* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84338120
161GATA1_26923725_Chip-Seq_HPCs_Mouse0.81873790
162MYB_26560356_Chip-Seq_TH2_Human0.81340533
163MYC_19079543_ChIP-ChIP_MESCs_Mouse0.81221797
164* STAT3_23295773_ChIP-Seq_U87_Human0.78518330
165ZFP281_18757296_ChIP-ChIP_E14_Mouse0.77975783
166PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.76761406
167POU5F1_16518401_ChIP-PET_MESCs_Mouse0.76742585
168AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.75426908
169AHR_22903824_ChIP-Seq_MCF-7_Human0.74437322
170TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73845730

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation7.02583672
2MP0001188_hyperpigmentation4.90952723
3MP0008877_abnormal_DNA_methylation3.46732610
4MP0003787_abnormal_imprinting3.24189371
5MP0008057_abnormal_DNA_replication3.17920651
6MP0000569_abnormal_digit_pigmentation3.14341362
7MP0010094_abnormal_chromosome_stability2.71017856
8MP0003121_genomic_imprinting2.68662187
9MP0003111_abnormal_nucleus_morphology2.29583513
10MP0005076_abnormal_cell_differentiation2.29357039
11MP0003077_abnormal_cell_cycle2.26194318
12MP0003890_abnormal_embryonic-extraembry2.02568023
13MP0010352_gastrointestinal_tract_polyps1.99403379
14MP0002638_abnormal_pupillary_reflex1.96440516
15MP0002396_abnormal_hematopoietic_system1.95666594
16MP0002102_abnormal_ear_morphology1.90032379
17MP0004808_abnormal_hematopoietic_stem1.88129910
18MP0003693_abnormal_embryo_hatching1.87359116
19MP0008058_abnormal_DNA_repair1.86197379
20MP0000647_abnormal_sebaceous_gland1.85366749
21* MP0002084_abnormal_developmental_patter1.73116362
22MP0000350_abnormal_cell_proliferation1.71663994
23MP0004957_abnormal_blastocyst_morpholog1.71290047
24MP0003123_paternal_imprinting1.67452041
25* MP0001730_embryonic_growth_arrest1.60671814
26MP0010307_abnormal_tumor_latency1.58092125
27MP0008007_abnormal_cellular_replicative1.55298523
28* MP0001672_abnormal_embryogenesis/_devel1.55012459
29* MP0005380_embryogenesis_phenotype1.55012459
30* MP0002085_abnormal_embryonic_tissue1.54431289
31MP0002095_abnormal_skin_pigmentation1.53605237
32MP0004197_abnormal_fetal_growth/weight/1.52351176
33MP0002751_abnormal_autonomic_nervous1.47347676
34MP0003122_maternal_imprinting1.46604561
35* MP0003984_embryonic_growth_retardation1.46428801
36* MP0002088_abnormal_embryonic_growth/wei1.44757068
37MP0000778_abnormal_nervous_system1.43781403
38MP0000428_abnormal_craniofacial_morphol1.42862643
39MP0003935_abnormal_craniofacial_develop1.41087608
40* MP0001697_abnormal_embryo_size1.38507853
41MP0002009_preneoplasia1.38206208
42MP0003136_yellow_coat_color1.37594392
43MP0003937_abnormal_limbs/digits/tail_de1.37289902
44MP0003880_abnormal_central_pattern1.37141529
45MP0001293_anophthalmia1.34021859
46MP0006292_abnormal_olfactory_placode1.33325259
47* MP0002086_abnormal_extraembryonic_tissu1.32801108
48MP0001968_abnormal_touch/_nociception1.32068737
49MP0009278_abnormal_bone_marrow1.31730063
50MP0000733_abnormal_muscle_development1.30859682
51MP0009703_decreased_birth_body1.30019749
52MP0000703_abnormal_thymus_morphology1.25458314
53MP0000432_abnormal_head_morphology1.23784654
54MP0004133_heterotaxia1.18488531
55MP0002925_abnormal_cardiovascular_devel1.16629998
56MP0003385_abnormal_body_wall1.15187705
57MP0000537_abnormal_urethra_morphology1.13536883
58MP0010030_abnormal_orbit_morphology1.12223669
59MP0001486_abnormal_startle_reflex1.11640576
60MP0002184_abnormal_innervation1.09918700
61MP0003045_fibrosis1.09717386
62MP0000631_abnormal_neuroendocrine_gland1.09408542
63MP0002127_abnormal_cardiovascular_syste1.09150095
64MP0002166_altered_tumor_susceptibility1.09033820
65MP0008961_abnormal_basal_metabolism1.07830384
66MP0003861_abnormal_nervous_system1.07626714
67MP0003755_abnormal_palate_morphology1.07359202
68MP0003567_abnormal_fetal_cardiomyocyte1.06448651
69MP0003763_abnormal_thymus_physiology1.06378929
70MP0003115_abnormal_respiratory_system1.04897165
71MP0003119_abnormal_digestive_system1.03984183
72* MP0002080_prenatal_lethality1.01541042
73MP0002736_abnormal_nociception_after0.99240631
74MP0002116_abnormal_craniofacial_bone0.98199615
75MP0005423_abnormal_somatic_nervous0.95849221
76MP0001529_abnormal_vocalization0.95431572
77MP0000955_abnormal_spinal_cord0.94825757
78MP0001849_ear_inflammation0.94825003
79MP0001299_abnormal_eye_distance/0.94134491
80MP0002092_abnormal_eye_morphology0.93888061
81MP0008932_abnormal_embryonic_tissue0.93103751
82MP0002006_tumorigenesis0.90617041
83MP0004233_abnormal_muscle_weight0.90405614
84MP0001286_abnormal_eye_development0.90357211
85MP0005623_abnormal_meninges_morphology0.89707912
86MP0003091_abnormal_cell_migration0.89561378
87MP0002697_abnormal_eye_size0.89534629
88MP0002210_abnormal_sex_determination0.89111262
89MP0009672_abnormal_birth_weight0.89017948
90MP0002653_abnormal_ependyma_morphology0.86733775
91MP0006072_abnormal_retinal_apoptosis0.86118420
92MP0005174_abnormal_tail_pigmentation0.86041032
93MP0003300_gastrointestinal_ulcer0.84656622
94MP0002398_abnormal_bone_marrow0.83940651
95MP0000566_synostosis0.83061657
96MP0005386_behavior/neurological_phenoty0.82982872
97MP0004924_abnormal_behavior0.82982872
98MP0001784_abnormal_fluid_regulation0.81943909
99MP0004885_abnormal_endolymph0.81821408
100MP0003705_abnormal_hypodermis_morpholog0.81409536
101MP0005409_darkened_coat_color0.81389764
102MP0003938_abnormal_ear_development0.81357527
103MP0003635_abnormal_synaptic_transmissio0.81052727
104MP0002877_abnormal_melanocyte_morpholog0.81029904
105MP0008995_early_reproductive_senescence0.80651388
106MP0000313_abnormal_cell_death0.80370371
107MP0002177_abnormal_outer_ear0.80192971
108MP0000383_abnormal_hair_follicle0.80171904
109MP0001915_intracranial_hemorrhage0.79600435
110MP0000516_abnormal_urinary_system0.79446356
111MP0005367_renal/urinary_system_phenotyp0.79446356
112MP0000015_abnormal_ear_pigmentation0.79312928
113MP0002272_abnormal_nervous_system0.79128315
114MP0002114_abnormal_axial_skeleton0.78961497
115MP0002938_white_spotting0.77304547
116MP0000266_abnormal_heart_morphology0.77187093
117MP0003942_abnormal_urinary_system0.76928129
118MP0004742_abnormal_vestibular_system0.76411499
119MP0004264_abnormal_extraembryonic_tissu0.76402942
120MP0003943_abnormal_hepatobiliary_system0.75845679
121MP0010678_abnormal_skin_adnexa0.75434279
122MP0005248_abnormal_Harderian_gland0.75373566
123MP0002557_abnormal_social/conspecific_i0.74210939
124MP0002932_abnormal_joint_morphology0.72596080
125MP0003786_premature_aging0.72585361
126MP0003566_abnormal_cell_adhesion0.71841397
127MP0005187_abnormal_penis_morphology0.71654402
128MP0002081_perinatal_lethality0.71529728
129MP0002233_abnormal_nose_morphology0.71517504
130MP0002735_abnormal_chemical_nociception0.71499299
131MP0001145_abnormal_male_reproductive0.71339060
132MP0001485_abnormal_pinna_reflex0.70857762
133MP0009053_abnormal_anal_canal0.70553637
134MP0002928_abnormal_bile_duct0.70284753
135MP0002734_abnormal_mechanical_nocicepti0.70163046
136MP0000049_abnormal_middle_ear0.69918648
137MP0006276_abnormal_autonomic_nervous0.69776939
138MP0002067_abnormal_sensory_capabilities0.69396271
139MP0002109_abnormal_limb_morphology0.69091066
140MP0002152_abnormal_brain_morphology0.68226310
141MP0002098_abnormal_vibrissa_morphology0.67003238
142MP0002160_abnormal_reproductive_system0.66051271
143MP0003698_abnormal_male_reproductive0.65880757
144MP0002075_abnormal_coat/hair_pigmentati0.65746074
145MP0005646_abnormal_pituitary_gland0.63101506
146MP0002752_abnormal_somatic_nervous0.62938885
147MP0003283_abnormal_digestive_organ0.62841700
148MP0001929_abnormal_gametogenesis0.62823270
149MP0002282_abnormal_trachea_morphology0.61928076
150MP0005551_abnormal_eye_electrophysiolog0.61282361
151MP0003868_abnormal_feces_composition0.60071879

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.33919945
2Volvulus (HP:0002580)4.02682291
3Hepatoblastoma (HP:0002884)3.24846384
4Long eyelashes (HP:0000527)3.22085413
5Pancreatic cysts (HP:0001737)3.08592161
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.00984926
7Short 4th metacarpal (HP:0010044)3.00984926
8Buphthalmos (HP:0000557)2.91448701
9Choroideremia (HP:0001139)2.86249137
10Conjunctival telangiectasia (HP:0000524)2.85652625
11Neoplasm of the adrenal cortex (HP:0100641)2.76571121
12Metaphyseal dysplasia (HP:0100255)2.76376590
13Thyroid carcinoma (HP:0002890)2.69870190
14Urethral obstruction (HP:0000796)2.64735938
15Neoplasm of the oral cavity (HP:0100649)2.54863685
16Macroorchidism (HP:0000053)2.54508366
17Pancreatic fibrosis (HP:0100732)2.52140477
18Medulloblastoma (HP:0002885)2.51835109
19True hermaphroditism (HP:0010459)2.51657978
20Increased nuchal translucency (HP:0010880)2.50259637
21Cortical dysplasia (HP:0002539)2.48579690
22Neoplasm of the tracheobronchial system (HP:0100552)2.44690752
23Ependymoma (HP:0002888)2.43864859
24Trigonocephaly (HP:0000243)2.42572932
25Lip pit (HP:0100267)2.42271770
26Abnormality of the nasal septum (HP:0000419)2.39781196
27Truncal obesity (HP:0001956)2.39299172
28Chromsome breakage (HP:0040012)2.38616521
29Narrow palate (HP:0000189)2.37396053
30Supernumerary ribs (HP:0005815)2.34409809
31Vertebral arch anomaly (HP:0008438)2.34061489
32Heterotopia (HP:0002282)2.33036264
33Astrocytoma (HP:0009592)2.32691944
34Abnormality of the astrocytes (HP:0100707)2.32691944
35Ectopic kidney (HP:0000086)2.29038743
36Abnormality of the labia minora (HP:0012880)2.28070401
37Prominent nose (HP:0000448)2.26767392
38Papillary thyroid carcinoma (HP:0002895)2.24443744
39Hyperventilation (HP:0002883)2.23047783
40Neonatal respiratory distress (HP:0002643)2.22385515
41Abnormal number of incisors (HP:0011064)2.17869499
42Supernumerary bones of the axial skeleton (HP:0009144)2.17835761
43Obsessive-compulsive behavior (HP:0000722)2.14825293
44Abnormality of the vasculature of the conjunctiva (HP:0008054)2.10505387
45Meckel diverticulum (HP:0002245)2.09390216
46Nephronophthisis (HP:0000090)2.09388029
47Neoplasm of the heart (HP:0100544)2.08447882
48Molar tooth sign on MRI (HP:0002419)2.06817466
49Abnormality of midbrain morphology (HP:0002418)2.06817466
50Broad thumb (HP:0011304)2.06457179
51Anal stenosis (HP:0002025)2.06440125
52Glioma (HP:0009733)2.05835645
53Deviation of the thumb (HP:0009603)2.04990557
54Deep philtrum (HP:0002002)2.04701961
55Hyperacusis (HP:0010780)2.04495896
56Aplasia/Hypoplasia of the uvula (HP:0010293)2.04487110
57Acute lymphatic leukemia (HP:0006721)2.03627401
58Proximal placement of thumb (HP:0009623)2.03627302
59Colon cancer (HP:0003003)2.03421435
60Facial hemangioma (HP:0000329)2.03401549
61Febrile seizures (HP:0002373)2.03035773
62Abnormality of the ileum (HP:0001549)2.02964431
63Abnormality of the 4th metacarpal (HP:0010012)2.01413388
64Midline defect of the nose (HP:0004122)1.98738978
65Lower limb asymmetry (HP:0100559)1.95860191
66Arteriovenous malformation (HP:0100026)1.94626295
67Chromosomal breakage induced by crosslinking agents (HP:0003221)1.94543500
68Stomach cancer (HP:0012126)1.93902008
69Chronic hepatic failure (HP:0100626)1.90870118
70Broad-based gait (HP:0002136)1.89581554
71Cystic liver disease (HP:0006706)1.89362405
72Malignant neoplasm of the central nervous system (HP:0100836)1.88882767
73Abnormal hair whorl (HP:0010721)1.87285526
74Protruding tongue (HP:0010808)1.87250498
75Embryonal renal neoplasm (HP:0011794)1.86415927
76Nephroblastoma (Wilms tumor) (HP:0002667)1.85865086
77Neoplasm of striated muscle (HP:0009728)1.85433311
78Acute myeloid leukemia (HP:0004808)1.83643843
79Hypoplasia of the maxilla (HP:0000327)1.83384903
80Gastrointestinal carcinoma (HP:0002672)1.82989116
81Malignant gastrointestinal tract tumors (HP:0006749)1.82989116
82Low anterior hairline (HP:0000294)1.82111447
83Skull defect (HP:0001362)1.81922039
84Renal duplication (HP:0000075)1.81665220
85Aplasia/Hypoplasia of the sternum (HP:0006714)1.81056435
86Abnormality of chromosome stability (HP:0003220)1.80494400
87Absent frontal sinuses (HP:0002688)1.79861008
88Abnormality of the parietal bone (HP:0002696)1.79786866
89Abnormality of the incisor (HP:0000676)1.78919723
90Abnormality of the renal medulla (HP:0100957)1.78816397
91Congenital hepatic fibrosis (HP:0002612)1.78649985
92Specific learning disability (HP:0001328)1.78512698
93Limited elbow extension (HP:0001377)1.77202896
94Sandal gap (HP:0001852)1.77099623
95Drooling (HP:0002307)1.76890743
96Shallow orbits (HP:0000586)1.76755496
97Abnormal biliary tract physiology (HP:0012439)1.75525576
98Bile duct proliferation (HP:0001408)1.75525576
99Cutis marmorata (HP:0000965)1.75323027
100Intestinal atresia (HP:0011100)1.74053734
101Rib fusion (HP:0000902)1.73792775
102Thick eyebrow (HP:0000574)1.73337118
103Dialeptic seizures (HP:0011146)1.72650873
104Genetic anticipation (HP:0003743)1.72581139
105Preaxial hand polydactyly (HP:0001177)1.71481820
106Aplasia/Hypoplasia of the tongue (HP:0010295)1.71481717
107Narrow forehead (HP:0000341)1.70871745
108Sparse lateral eyebrow (HP:0005338)1.70697957
109Hypoplastic labia majora (HP:0000059)1.70218455
110Transitional cell carcinoma of the bladder (HP:0006740)1.69590700
111Rhabdomyosarcoma (HP:0002859)1.69336589
112Abnormality of the diencephalon (HP:0010662)1.68932602
113Basal cell carcinoma (HP:0002671)1.68611984
114Shawl scrotum (HP:0000049)1.68548503
115Renovascular hypertension (HP:0100817)1.67927281
116Skin tags (HP:0010609)1.67852438
117Hamartoma (HP:0010566)1.67738773
118Congenital glaucoma (HP:0001087)1.67695835
119Impulsivity (HP:0100710)1.67564916
120Broad phalanges of the hand (HP:0009768)1.67542813
121Overlapping toe (HP:0001845)1.66914437
122Broad palm (HP:0001169)1.66574317
123Septo-optic dysplasia (HP:0100842)1.66482803
124Dislocated radial head (HP:0003083)1.65816805
125Highly arched eyebrow (HP:0002553)1.64317929
126Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.63832530
127Spinal cord lesions (HP:0100561)1.62350841
128Syringomyelia (HP:0003396)1.62350841
129Sparse scalp hair (HP:0002209)1.60023369
130Aqueductal stenosis (HP:0002410)1.59935708
131Hemangiomatosis (HP:0007461)1.59805207
132Optic nerve hypoplasia (HP:0000609)1.59067212
133Leiomyosarcoma (HP:0100243)1.59034152
134Uterine leiomyosarcoma (HP:0002891)1.59034152
135Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.58971325
136Hypopigmentation of the fundus (HP:0007894)1.58739135
137Broad finger (HP:0001500)1.58138946
138Abnormality of chromosome segregation (HP:0002916)1.58122598
139Oligodactyly (hands) (HP:0001180)1.57973501
140Anencephaly (HP:0002323)1.57671065
141Arnold-Chiari malformation (HP:0002308)1.57513484
142Overriding aorta (HP:0002623)1.57450711
143Autism (HP:0000717)1.56815049
144Wide intermamillary distance (HP:0006610)1.56674626
145Patellar aplasia (HP:0006443)1.55994582
146Sloping forehead (HP:0000340)1.55982575
147Clubbing of toes (HP:0100760)1.55761860
148Abnormality of the frontal sinuses (HP:0002687)1.55301488
149Cafe-au-lait spot (HP:0000957)1.54979664
150Abnormality of the distal phalanx of the thumb (HP:0009617)1.54866564
151Hamartoma of the eye (HP:0010568)1.54853406
152Abnormality of the radial head (HP:0003995)1.54663565
153Abnormality of the carotid arteries (HP:0005344)1.54398726
154Microtia (HP:0008551)1.54107336
155Excessive salivation (HP:0003781)1.53907092
156Abnormality of the intervertebral disk (HP:0005108)1.53560627
157Bowel diverticulosis (HP:0005222)1.52667750
158Elfin facies (HP:0004428)1.52427164
159Thyroiditis (HP:0100646)1.51855694
160Abnormality of the labia majora (HP:0012881)1.51679224
161Smooth philtrum (HP:0000319)1.51676663
162Short 1st metacarpal (HP:0010034)1.51296763
163Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.51296763
164Spina bifida occulta (HP:0003298)1.51188578
165Bladder carcinoma (HP:0002862)1.50729854
166Bladder neoplasm (HP:0009725)1.50729854

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.64039286
2PINK13.76427476
3CDC73.58729690
4BRD43.47074226
5TNIK3.06083987
6FRK2.76087876
7LATS12.73506064
8CAMK1G2.56186833
9CAMK1D2.38498839
10CASK2.36773697
11MAP3K102.22125187
12NTRK32.13579897
13NEK22.10858245
14STK392.09505564
15PNCK2.01736621
16WNK31.99700731
17EEF2K1.86865677
18SIK21.86261249
19TRIM281.60406911
20MTOR1.59262571
21CDK91.53456478
22CHEK11.52433315
23ATR1.43593954
24STK101.41862336
25MELK1.37228266
26MAP4K11.35353232
27ATM1.33118984
28STK31.31684417
29BMPR1B1.30001432
30MKNK11.29406882
31WEE11.28738548
32TTK1.27776830
33MKNK21.27226153
34MAP3K91.23398408
35CDK41.23060495
36WNK41.22472840
37CHEK21.19169685
38NTRK21.19094323
39CDK61.18823525
40PDGFRB1.17952331
41CDK71.15610095
42MARK11.14409278
43MAPK131.13548287
44DMPK1.12527118
45FGFR31.12211593
46ALK1.11160323
47CDK21.08031020
48ICK1.04101131
49TAF11.03070250
50HIPK21.02185274
51FGFR21.00316563
52STK40.96058666
53SRPK10.95270127
54SGK30.94501566
55WNK10.93579037
56ACVR1B0.92964106
57PDGFRA0.91448335
58PLK30.90314775
59CHUK0.89583067
60DYRK1A0.89572353
61SGK20.87635821
62PAK30.87302886
63OXSR10.86831371
64RIPK10.85701847
65* CDK10.84811536
66PLK10.83760657
67CSNK1A1L0.83393971
68MAPK140.82367614
69CSNK1D0.80281441
70PRKD20.80033854
71TYRO30.79885115
72PLK40.79798767
73AURKB0.79291023
74MARK20.78873119
75RPS6KA40.77543222
76DYRK30.75410961
77RPS6KB20.75063796
78NUAK10.74776523
79MARK30.74731591
80MAPK100.74344390
81CDC42BPA0.73598748
82LATS20.73416615
83TGFBR10.73359817
84SGK2230.73034458
85SGK4940.73034458
86CDK30.72658130
87CSNK1E0.72521106
88PIK3CA0.72454119
89INSRR0.72078095
90* GSK3B0.71710276
91NLK0.70707295
92PRKDC0.68097653
93GRK10.66525636
94PRKCH0.65535715
95TAOK10.65432527
96ZAK0.65033999
97PIM10.63748987
98TEC0.61763574
99PASK0.59811110
100MAPK10.59767535
101FGFR10.59060421
102RPS6KB10.58859787
103STK110.57775290
104DYRK20.57399227
105ERBB20.54549090
106MINK10.54524825
107* MAPK80.54105729
108ITK0.53891048
109AKT10.53664025
110CSNK1A10.53119063
111CSNK1G20.52403589
112PRKD30.52376181
113NEK10.52038974
114MAP3K40.51352884
115CSNK1G10.50409274
116CAMK40.48791887
117EPHA30.47469989
118SGK10.47357084
119EPHA40.46438713
120MAP3K60.45953265
121TXK0.45268538
122CAMK10.44792294
123VRK10.44150382
124MAP4K20.43523014
125PRKCG0.43046609
126TSSK60.42951356
127HCK0.42550363
128PTK60.42223605
129MAPK70.41393583
130RPS6KA50.40519671
131BRSK20.40020642
132CSNK1G30.38482726
133MAPK90.38005875
134ERBB30.36790050
135AKT30.36189889
136PAK20.35552916
137MAP3K80.35388454
138CSF1R0.34617089
139STK38L0.34327151
140PLK20.34137472
141SCYL20.33850754
142TTN0.33341303
143MAP3K70.33257918

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.12378170
2Protein export_Homo sapiens_hsa030602.14165918
3mRNA surveillance pathway_Homo sapiens_hsa030151.87759995
4Cell cycle_Homo sapiens_hsa041101.83832954
5Non-homologous end-joining_Homo sapiens_hsa034501.77387305
6Nicotine addiction_Homo sapiens_hsa050331.67820022
7RNA transport_Homo sapiens_hsa030131.63152818
8Fanconi anemia pathway_Homo sapiens_hsa034601.62296124
9MicroRNAs in cancer_Homo sapiens_hsa052061.60643557
10Spliceosome_Homo sapiens_hsa030401.58646588
11Lysine degradation_Homo sapiens_hsa003101.49681453
12Dorso-ventral axis formation_Homo sapiens_hsa043201.46463679
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.45134959
14Mismatch repair_Homo sapiens_hsa034301.44671479
15Adherens junction_Homo sapiens_hsa045201.42915197
16Primary immunodeficiency_Homo sapiens_hsa053401.41572060
17Renin secretion_Homo sapiens_hsa049241.37952579
18Notch signaling pathway_Homo sapiens_hsa043301.35733445
19Circadian entrainment_Homo sapiens_hsa047131.34683259
20Propanoate metabolism_Homo sapiens_hsa006401.32873547
21RNA degradation_Homo sapiens_hsa030181.32276652
22Thyroid hormone signaling pathway_Homo sapiens_hsa049191.32216251
23Chronic myeloid leukemia_Homo sapiens_hsa052201.31559048
24Taste transduction_Homo sapiens_hsa047421.31296838
25Glutamatergic synapse_Homo sapiens_hsa047241.31173015
26Basal cell carcinoma_Homo sapiens_hsa052171.30139790
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.28930362
28Insulin secretion_Homo sapiens_hsa049111.28749895
29Transcriptional misregulation in cancer_Homo sapiens_hsa052021.27963951
30Colorectal cancer_Homo sapiens_hsa052101.25840500
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.21754834
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.21509631
33Cholinergic synapse_Homo sapiens_hsa047251.21296299
34Serotonergic synapse_Homo sapiens_hsa047261.19975821
35B cell receptor signaling pathway_Homo sapiens_hsa046621.19653546
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18241534
37Basal transcription factors_Homo sapiens_hsa030221.16604861
38Prostate cancer_Homo sapiens_hsa052151.16039987
39HTLV-I infection_Homo sapiens_hsa051661.15114950
40Wnt signaling pathway_Homo sapiens_hsa043101.14632051
41mTOR signaling pathway_Homo sapiens_hsa041501.14083441
42Homologous recombination_Homo sapiens_hsa034401.12970501
43Vitamin B6 metabolism_Homo sapiens_hsa007501.11400936
44DNA replication_Homo sapiens_hsa030301.11182665
45Selenocompound metabolism_Homo sapiens_hsa004501.09133505
46Hippo signaling pathway_Homo sapiens_hsa043901.09124892
47Endometrial cancer_Homo sapiens_hsa052131.09016394
48TGF-beta signaling pathway_Homo sapiens_hsa043501.08425652
49Base excision repair_Homo sapiens_hsa034101.07796055
50Oocyte meiosis_Homo sapiens_hsa041141.05767628
51Gastric acid secretion_Homo sapiens_hsa049711.05570225
52T cell receptor signaling pathway_Homo sapiens_hsa046601.04968970
53Salivary secretion_Homo sapiens_hsa049701.04231146
54Glucagon signaling pathway_Homo sapiens_hsa049221.03432109
55Non-small cell lung cancer_Homo sapiens_hsa052231.01239862
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.00204099
57RNA polymerase_Homo sapiens_hsa030200.99374290
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98758449
59Hedgehog signaling pathway_Homo sapiens_hsa043400.98319361
60Pancreatic cancer_Homo sapiens_hsa052120.98269441
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98244619
62Proteoglycans in cancer_Homo sapiens_hsa052050.97985757
63Small cell lung cancer_Homo sapiens_hsa052220.97555957
64Thyroid cancer_Homo sapiens_hsa052160.97064238
65Herpes simplex infection_Homo sapiens_hsa051680.96392859
66Thyroid hormone synthesis_Homo sapiens_hsa049180.95656306
67Viral carcinogenesis_Homo sapiens_hsa052030.94813037
68Pathways in cancer_Homo sapiens_hsa052000.93512308
69Amphetamine addiction_Homo sapiens_hsa050310.92677755
70Glioma_Homo sapiens_hsa052140.91640725
71Renal cell carcinoma_Homo sapiens_hsa052110.89700391
72Cocaine addiction_Homo sapiens_hsa050300.88549764
73MAPK signaling pathway_Homo sapiens_hsa040100.88514411
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.87760158
75Viral myocarditis_Homo sapiens_hsa054160.87555538
76p53 signaling pathway_Homo sapiens_hsa041150.87453518
77FoxO signaling pathway_Homo sapiens_hsa040680.87420075
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87393701
79Long-term potentiation_Homo sapiens_hsa047200.87316217
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.85430675
81Acute myeloid leukemia_Homo sapiens_hsa052210.85125557
82AMPK signaling pathway_Homo sapiens_hsa041520.84921630
83ErbB signaling pathway_Homo sapiens_hsa040120.84580311
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83918600
85Calcium signaling pathway_Homo sapiens_hsa040200.81803172
86Type II diabetes mellitus_Homo sapiens_hsa049300.80979453
87Estrogen signaling pathway_Homo sapiens_hsa049150.79436131
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79306883
89One carbon pool by folate_Homo sapiens_hsa006700.78895399
90Platelet activation_Homo sapiens_hsa046110.78321197
91Gap junction_Homo sapiens_hsa045400.77797687
92beta-Alanine metabolism_Homo sapiens_hsa004100.77639732
93Choline metabolism in cancer_Homo sapiens_hsa052310.77583418
94Hepatitis B_Homo sapiens_hsa051610.77460446
95GABAergic synapse_Homo sapiens_hsa047270.77228068
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76956958
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.76702912
98Melanogenesis_Homo sapiens_hsa049160.76262604
99Focal adhesion_Homo sapiens_hsa045100.76098312
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75065516
101Nucleotide excision repair_Homo sapiens_hsa034200.74315992
102Bile secretion_Homo sapiens_hsa049760.74085327
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73729898
104Epstein-Barr virus infection_Homo sapiens_hsa051690.73720842
105Rap1 signaling pathway_Homo sapiens_hsa040150.73079994
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72868870
107Antigen processing and presentation_Homo sapiens_hsa046120.72803169
108Prolactin signaling pathway_Homo sapiens_hsa049170.72671235
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71829195
110African trypanosomiasis_Homo sapiens_hsa051430.71625381
111Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71344245
112GnRH signaling pathway_Homo sapiens_hsa049120.71253591
113Inositol phosphate metabolism_Homo sapiens_hsa005620.70584686
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70442489
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.70290067
116Axon guidance_Homo sapiens_hsa043600.69998886
117Long-term depression_Homo sapiens_hsa047300.69107898
118Nitrogen metabolism_Homo sapiens_hsa009100.68390482
119Pancreatic secretion_Homo sapiens_hsa049720.67723761
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67574484
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67399677
122Morphine addiction_Homo sapiens_hsa050320.66709375
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66427939
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.65822010
125Leukocyte transendothelial migration_Homo sapiens_hsa046700.65368064
126Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65257603
127Olfactory transduction_Homo sapiens_hsa047400.64810987
128Phototransduction_Homo sapiens_hsa047440.63730451
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63666927
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63075786
131Melanoma_Homo sapiens_hsa052180.62900292
132Osteoclast differentiation_Homo sapiens_hsa043800.61823306
133Chemokine signaling pathway_Homo sapiens_hsa040620.60961780
134Alcoholism_Homo sapiens_hsa050340.60009087
135Hematopoietic cell lineage_Homo sapiens_hsa046400.59764555
136Circadian rhythm_Homo sapiens_hsa047100.59585029
137Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.58967364
138cAMP signaling pathway_Homo sapiens_hsa040240.58490382
139Tight junction_Homo sapiens_hsa045300.58402845
140Measles_Homo sapiens_hsa051620.57498495
141Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57357418
142Dopaminergic synapse_Homo sapiens_hsa047280.56477001
143Oxytocin signaling pathway_Homo sapiens_hsa049210.55557150
144ECM-receptor interaction_Homo sapiens_hsa045120.55171239
145Steroid biosynthesis_Homo sapiens_hsa001000.54043958
146Tryptophan metabolism_Homo sapiens_hsa003800.53122028
147Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50843396

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