BRAF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)5.56668111
2presynaptic membrane assembly (GO:0097105)5.19206321
3regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.11411266
4vocalization behavior (GO:0071625)5.05169524
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.94802451
6neuron cell-cell adhesion (GO:0007158)4.86313797
7neurotransmitter-gated ion channel clustering (GO:0072578)4.83496825
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.79208461
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.74479207
10synaptic vesicle exocytosis (GO:0016079)4.74061250
11glutamate secretion (GO:0014047)4.59795752
12presynaptic membrane organization (GO:0097090)4.54986499
13postsynaptic membrane organization (GO:0001941)4.53685437
14phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.46364437
15regulation of glutamate receptor signaling pathway (GO:1900449)4.41643481
16protein localization to synapse (GO:0035418)4.31874092
17cytoplasmic mRNA processing body assembly (GO:0033962)4.22521031
18locomotory exploration behavior (GO:0035641)4.22184875
19* regulation of synaptic vesicle exocytosis (GO:2000300)4.15919454
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.13406224
21synaptic transmission, glutamatergic (GO:0035249)4.11742542
22negative regulation of synaptic transmission, GABAergic (GO:0032229)4.10958357
23neuron-neuron synaptic transmission (GO:0007270)4.10211820
24monoubiquitinated protein deubiquitination (GO:0035520)3.96643232
25nerve growth factor signaling pathway (GO:0038180)3.94161358
26startle response (GO:0001964)3.91897441
27synaptic vesicle maturation (GO:0016188)3.89117348
28interkinetic nuclear migration (GO:0022027)3.88339817
29glutamate receptor signaling pathway (GO:0007215)3.87742567
30regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.86010402
31neurotransmitter secretion (GO:0007269)3.82428510
32histone H3-K4 trimethylation (GO:0080182)3.82397566
33gamma-aminobutyric acid signaling pathway (GO:0007214)3.82199605
34nuclear pore complex assembly (GO:0051292)3.79938711
35positive regulation of synapse maturation (GO:0090129)3.77889012
36establishment of protein localization to Golgi (GO:0072600)3.75110544
37* regulation of synaptic vesicle transport (GO:1902803)3.74699879
38negative regulation of dendrite morphogenesis (GO:0050774)3.70486446
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.69588869
40positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.69143910
41neuronal action potential propagation (GO:0019227)3.66113517
42cerebellar granule cell differentiation (GO:0021707)3.59782182
43regulation of excitatory postsynaptic membrane potential (GO:0060079)3.55876330
44* long-term synaptic potentiation (GO:0060291)3.55550969
45peptidyl-lysine trimethylation (GO:0018023)3.49479259
46protein targeting to Golgi (GO:0000042)3.48083883
47retrograde transport, vesicle recycling within Golgi (GO:0000301)3.46871330
48regulation of postsynaptic membrane potential (GO:0060078)3.45769595
49regulation of long-term neuronal synaptic plasticity (GO:0048169)3.45443042
50response to histamine (GO:0034776)3.45110714
51regulation of synapse maturation (GO:0090128)3.44914135
52protein K11-linked deubiquitination (GO:0035871)3.43226736
53cerebellar Purkinje cell differentiation (GO:0021702)3.40671278
54regulation of neuronal synaptic plasticity (GO:0048168)3.39019298
55cellular response to ethanol (GO:0071361)3.35946316
56mechanosensory behavior (GO:0007638)3.34345467
57positive regulation of membrane potential (GO:0045838)3.33893092
58long-term memory (GO:0007616)3.33554542
59G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.31885815
60synaptic vesicle endocytosis (GO:0048488)3.30255644
61regulation of synaptic transmission, glutamatergic (GO:0051966)3.29208371
62negative regulation of translation, ncRNA-mediated (GO:0040033)3.22902954
63regulation of translation, ncRNA-mediated (GO:0045974)3.22902954
64negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.22902954
65exploration behavior (GO:0035640)3.18479324
66nuclear pore organization (GO:0006999)3.18228764
67innervation (GO:0060384)3.16510036
68detection of calcium ion (GO:0005513)3.14899386
69negative regulation of dendrite development (GO:2000171)3.13634499
70* regulation of neurotransmitter secretion (GO:0046928)3.12128995
71positive regulation of neurotransmitter secretion (GO:0001956)3.10318744
72* regulation of synaptic plasticity (GO:0048167)3.10188009
73neuron recognition (GO:0008038)3.10082683
74regulation of synaptic transmission, GABAergic (GO:0032228)3.09604486
75gamma-aminobutyric acid transport (GO:0015812)3.07153566
76negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05202650
77neurotransmitter transport (GO:0006836)3.03444316
78positive regulation of neurotransmitter transport (GO:0051590)3.01858351
79positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.01384318
80regulation of Rac protein signal transduction (GO:0035020)3.00713162
81neural tube formation (GO:0001841)3.00500566
82regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.00217606
83nucleus localization (GO:0051647)2.98928422
84positive regulation of granulocyte differentiation (GO:0030854)2.98903024
85regulation of RNA export from nucleus (GO:0046831)2.96351696
86synapse assembly (GO:0007416)2.95112339
87auditory behavior (GO:0031223)2.94018309
88histone H3-K36 demethylation (GO:0070544)2.93936738
89definitive hemopoiesis (GO:0060216)2.92466129
90membrane depolarization during action potential (GO:0086010)2.90974511
91histone H3-K9 demethylation (GO:0033169)2.89543918
92membrane depolarization (GO:0051899)2.89314386
93positive regulation of synapse assembly (GO:0051965)2.88979880
94Golgi to endosome transport (GO:0006895)2.88649673
95striatum development (GO:0021756)2.88325947
96regulation of female receptivity (GO:0045924)2.87603906
97histone H3-K4 methylation (GO:0051568)2.87048617
98embryonic retina morphogenesis in camera-type eye (GO:0060059)2.86922463
99fear response (GO:0042596)2.86649070
100regulation of pigment cell differentiation (GO:0050932)2.86387240
101behavioral defense response (GO:0002209)2.86253993
102behavioral fear response (GO:0001662)2.86253993
103phospholipid translocation (GO:0045332)2.84080079
104lipid translocation (GO:0034204)2.84080079
105axonal fasciculation (GO:0007413)2.83634729
106* regulation of neurotransmitter transport (GO:0051588)2.83595199
107proline transport (GO:0015824)2.83319021
108histone lysine methylation (GO:0034968)2.82927801
109inositol phosphate catabolic process (GO:0071545)2.80977149
110positive regulation of developmental pigmentation (GO:0048087)2.80710803
111* learning (GO:0007612)2.80559453
112urinary tract smooth muscle contraction (GO:0014848)2.80222588
113transmission of nerve impulse (GO:0019226)2.79019765
114positive regulation of synaptic transmission, GABAergic (GO:0032230)2.77970853
115pore complex assembly (GO:0046931)2.77704528
116regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.76985709
117histone lysine demethylation (GO:0070076)2.76966736
118* positive regulation of synaptic transmission (GO:0050806)2.76714326
119positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.75463156
120regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.75463156
121female mating behavior (GO:0060180)2.75328962
122peptidyl-threonine phosphorylation (GO:0018107)2.75312057
123regulation of respiratory system process (GO:0044065)2.75129548
124* synaptic transmission (GO:0007268)2.74535511
125serotonin metabolic process (GO:0042428)2.74217357
126regulation of vesicle fusion (GO:0031338)2.74081664
127dendrite development (GO:0016358)2.73901310
128establishment of nucleus localization (GO:0040023)2.73233138
129regulation of glutamate secretion (GO:0014048)2.72852878
130membrane hyperpolarization (GO:0060081)2.72387561
131regulation of clathrin-mediated endocytosis (GO:2000369)2.72355531
132histone demethylation (GO:0016577)2.72084853
133cochlea development (GO:0090102)2.71447097
134transferrin transport (GO:0033572)2.70620410
135behavioral response to cocaine (GO:0048148)2.68840262
136cerebral cortex radially oriented cell migration (GO:0021799)2.67706120
137regulation of synapse assembly (GO:0051963)2.66761027
138regulation of neurotransmitter levels (GO:0001505)2.65850107
139peptidyl-lysine methylation (GO:0018022)2.65706656
140long term synaptic depression (GO:0060292)2.65657699
141* regulation of synaptic transmission (GO:0050804)2.64481226
142response to auditory stimulus (GO:0010996)2.64078657
143histone H3-K9 modification (GO:0061647)2.63590410
144regulation of nucleobase-containing compound transport (GO:0032239)2.61681131
145central nervous system projection neuron axonogenesis (GO:0021952)2.61631541
146histone H3-K9 methylation (GO:0051567)2.60983812
147regulation of ARF protein signal transduction (GO:0032012)2.57273609
148microtubule anchoring (GO:0034453)2.55319870
149central nervous system neuron axonogenesis (GO:0021955)2.52221530
150protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.51772535
151protein localization to Golgi apparatus (GO:0034067)2.50976937
152* negative regulation of neurotransmitter secretion (GO:0046929)2.50762113
153protein K48-linked deubiquitination (GO:0071108)2.50359556
154early endosome to late endosome transport (GO:0045022)2.46932397
155regulation of Rap GTPase activity (GO:0032317)2.45279178
156pre-miRNA processing (GO:0031054)2.44944132
157regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.44926536
158positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.44926536
159mitotic sister chromatid cohesion (GO:0007064)2.44385114
160peptidyl-threonine modification (GO:0018210)2.42898993
161microtubule nucleation (GO:0007020)2.36508551
162cell differentiation in hindbrain (GO:0021533)2.34954558
163histone H4-K16 acetylation (GO:0043984)2.33028833
164protein dealkylation (GO:0008214)2.32992096
165protein demethylation (GO:0006482)2.32992096
166negative regulation of NF-kappaB import into nucleus (GO:0042347)2.30750832
167embryonic hemopoiesis (GO:0035162)2.30603698
168* negative regulation of neurotransmitter transport (GO:0051589)2.28069333
169regulation of growth hormone secretion (GO:0060123)2.27455909
170regulation of DNA damage checkpoint (GO:2000001)2.25746737
171intra-Golgi vesicle-mediated transport (GO:0006891)2.25529568
172positive regulation of mRNA catabolic process (GO:0061014)2.21711003
173regulation of protein glycosylation (GO:0060049)2.21275641
174positive regulation of macroautophagy (GO:0016239)2.21107114
175RNA destabilization (GO:0050779)2.19947744
176regulation of histone H3-K27 methylation (GO:0061085)2.18078816
177positive regulation of Rap GTPase activity (GO:0032854)2.17294838
178N-terminal protein amino acid acetylation (GO:0006474)2.14976540
179histone methylation (GO:0016571)2.13926771
180negative regulation of T-helper cell differentiation (GO:0045623)2.13228917
181negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.13228917
182phosphatidylinositol phosphorylation (GO:0046854)2.11881579

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.84415474
2GBX2_23144817_ChIP-Seq_PC3_Human4.67532357
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.80595255
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.66696476
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.55259376
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.50928232
7TAF15_26573619_Chip-Seq_HEK293_Human2.41532082
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.34632110
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25027362
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.24245133
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.19639294
12SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.18628513
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.14539815
14REST_21632747_ChIP-Seq_MESCs_Mouse2.13995985
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.13432284
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.12309171
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11865230
18SMAD4_21799915_ChIP-Seq_A2780_Human2.11463335
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11335374
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01932413
21P300_19829295_ChIP-Seq_ESCs_Human1.99153845
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.95564141
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.94480768
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.92152264
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.91465024
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91214269
27BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.88317314
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.87175477
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.87175477
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.85441826
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85398919
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.79951160
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.78854504
34FUS_26573619_Chip-Seq_HEK293_Human1.78636289
35* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.78353912
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.78353531
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78060416
38MTF2_20144788_ChIP-Seq_MESCs_Mouse1.75502529
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.74438905
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.69503677
41DROSHA_22980978_ChIP-Seq_HELA_Human1.68910958
42STAT3_23295773_ChIP-Seq_U87_Human1.67152990
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.66621316
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.64446257
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.63616922
46AR_21572438_ChIP-Seq_LNCaP_Human1.63187752
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.63183253
48REST_18959480_ChIP-ChIP_MESCs_Mouse1.62215519
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.61353944
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60940231
51* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.59392682
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56090864
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.55135513
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53784424
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51494939
56TCF4_23295773_ChIP-Seq_U87_Human1.50401501
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.48876026
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48485842
59SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46343697
60AR_25329375_ChIP-Seq_VCAP_Human1.45989889
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.44771287
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42435813
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.42196730
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.41931492
65RNF2_27304074_Chip-Seq_NSC_Mouse1.41078817
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.40630418
67CBP_20019798_ChIP-Seq_JUKART_Human1.38838838
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38838838
69GATA1_22025678_ChIP-Seq_K562_Human1.38492433
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.38195410
71STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.37661289
72FLI1_27457419_Chip-Seq_LIVER_Mouse1.37443606
73ER_23166858_ChIP-Seq_MCF-7_Human1.37199689
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35958350
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.35057002
76AHR_22903824_ChIP-Seq_MCF-7_Human1.34728183
77EGR1_19374776_ChIP-ChIP_THP-1_Human1.33985790
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30865019
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.30762378
80WT1_19549856_ChIP-ChIP_CCG9911_Human1.29893973
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.28843318
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28776514
83* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28012643
84E2F1_18555785_Chip-Seq_ESCs_Mouse1.27632327
85RUNX2_22187159_ChIP-Seq_PCA_Human1.27322422
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23672957
87EWS_26573619_Chip-Seq_HEK293_Human1.23651765
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23457700
89TP53_18474530_ChIP-ChIP_U2OS_Human1.22394479
90YAP1_20516196_ChIP-Seq_MESCs_Mouse1.21837393
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21746561
92CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20983231
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20696997
94P53_22387025_ChIP-Seq_ESCs_Mouse1.20671751
95PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20503669
96AR_19668381_ChIP-Seq_PC3_Human1.20441436
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19965064
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19585153
99TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19561694
100TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.18587879
101RUNX_20019798_ChIP-Seq_JUKART_Human1.18488755
102PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18206810
103PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17545028
104FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17113781
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16763431
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16763431
107P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16413322
108NFE2_27457419_Chip-Seq_LIVER_Mouse1.15871349
109SOX9_26525672_Chip-Seq_HEART_Mouse1.15854806
110CMYC_18555785_Chip-Seq_ESCs_Mouse1.13301722
111IGF1R_20145208_ChIP-Seq_DFB_Human1.13229970
112VDR_22108803_ChIP-Seq_LS180_Human1.12367053
113NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12293519
114NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12293519
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11283997
116BCAT_22108803_ChIP-Seq_LS180_Human1.10646385
117PRDM14_20953172_ChIP-Seq_ESCs_Human1.10335274
118TCF4_18268006_ChIP-ChIP_LS174T_Human1.10231238
119SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09637719
120STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08877886
121* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.08396464
122CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07729269
123VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07554199
124Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07436421
125ZNF274_21170338_ChIP-Seq_K562_Hela1.07237125
126OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06938212
127TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05994729
128STAT3_18555785_Chip-Seq_ESCs_Mouse1.05062503
129FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.05024149
130MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04661355
131CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.04602856
132TP53_16413492_ChIP-PET_HCT116_Human1.04136081
133SOX2_18555785_Chip-Seq_ESCs_Mouse1.03474378
134RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02578944
135EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01474501
136LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00677403

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.61642445
2MP0004859_abnormal_synaptic_plasticity4.73331584
3MP0003880_abnormal_central_pattern4.36589915
4* MP0003635_abnormal_synaptic_transmissio3.51360028
5MP0004270_analgesia3.17026353
6MP0009745_abnormal_behavioral_response3.12062253
7MP0009046_muscle_twitch3.06983850
8MP0002009_preneoplasia3.01561580
9MP0009780_abnormal_chondrocyte_physiolo2.99290353
10* MP0002063_abnormal_learning/memory/cond2.98009413
11MP0003787_abnormal_imprinting2.93196155
12MP0005646_abnormal_pituitary_gland2.83474430
13MP0002064_seizures2.79455360
14MP0001968_abnormal_touch/_nociception2.77414972
15MP0002572_abnormal_emotion/affect_behav2.68746039
16MP0002734_abnormal_mechanical_nocicepti2.47156973
17MP0002272_abnormal_nervous_system2.34250046
18MP0002735_abnormal_chemical_nociception2.33943704
19MP0002736_abnormal_nociception_after2.33484524
20MP0003122_maternal_imprinting2.26452418
21MP0001486_abnormal_startle_reflex2.17177690
22MP0002822_catalepsy2.12177239
23MP0005645_abnormal_hypothalamus_physiol2.09763798
24MP0001501_abnormal_sleep_pattern2.01713790
25MP0002067_abnormal_sensory_capabilities2.00761405
26MP0001984_abnormal_olfaction1.97848416
27MP0008995_early_reproductive_senescence1.91412301
28MP0005171_absent_coat_pigmentation1.82920977
29MP0002876_abnormal_thyroid_physiology1.77833019
30MP0010352_gastrointestinal_tract_polyps1.76748611
31MP0002557_abnormal_social/conspecific_i1.72496786
32MP0000778_abnormal_nervous_system1.65730030
33MP0003656_abnormal_erythrocyte_physiolo1.65478364
34MP0003183_abnormal_peptide_metabolism1.61939556
35MP0010386_abnormal_urinary_bladder1.59541124
36MP0005423_abnormal_somatic_nervous1.59217386
37MP0003879_abnormal_hair_cell1.57833863
38* MP0002184_abnormal_innervation1.57308394
39MP0004924_abnormal_behavior1.57120425
40MP0005386_behavior/neurological_phenoty1.57120425
41MP0001970_abnormal_pain_threshold1.55680033
42MP0001440_abnormal_grooming_behavior1.54558144
43MP0002733_abnormal_thermal_nociception1.51689928
44MP0005551_abnormal_eye_electrophysiolog1.51153462
45MP0002638_abnormal_pupillary_reflex1.50999350
46MP0003690_abnormal_glial_cell1.49711517
47MP0001502_abnormal_circadian_rhythm1.49533017
48MP0003121_genomic_imprinting1.48239946
49MP0002909_abnormal_adrenal_gland1.47381385
50MP0006276_abnormal_autonomic_nervous1.47370775
51* MP0004811_abnormal_neuron_physiology1.45746933
52MP0000569_abnormal_digit_pigmentation1.36439110
53* MP0001188_hyperpigmentation1.36183199
54MP0005187_abnormal_penis_morphology1.35068029
55MP0003045_fibrosis1.28485969
56MP0004043_abnormal_pH_regulation1.27730662
57* MP0002882_abnormal_neuron_morphology1.27415558
58MP0002166_altered_tumor_susceptibility1.26065545
59* MP0008569_lethality_at_weaning1.25895396
60MP0004808_abnormal_hematopoietic_stem1.23721594
61MP0006292_abnormal_olfactory_placode1.23424048
62MP0000955_abnormal_spinal_cord1.18898397
63MP0005409_darkened_coat_color1.17401840
64MP0005499_abnormal_olfactory_system1.16682645
65MP0005394_taste/olfaction_phenotype1.16682645
66MP0004858_abnormal_nervous_system1.16252780
67* MP0002066_abnormal_motor_capabilities/c1.14203222
68MP0000013_abnormal_adipose_tissue1.13464575
69MP0005248_abnormal_Harderian_gland1.13086050
70MP0001177_atelectasis1.12870418
71MP0000427_abnormal_hair_cycle1.12427166
72MP0003303_peritoneal_inflammation1.09481286
73MP0004134_abnormal_chest_morphology1.08732847
74MP0004885_abnormal_endolymph1.06983616
75MP0008961_abnormal_basal_metabolism1.05430726
76MP0003633_abnormal_nervous_system1.05192685
77MP0002396_abnormal_hematopoietic_system1.02630001
78MP0004130_abnormal_muscle_cell1.02136744
79* MP0000631_abnormal_neuroendocrine_gland0.99717588
80* MP0002152_abnormal_brain_morphology0.98610696
81MP0001963_abnormal_hearing_physiology0.98231693
82MP0008877_abnormal_DNA_methylation0.97418872
83MP0001986_abnormal_taste_sensitivity0.96868929
84MP0003763_abnormal_thymus_physiology0.96769409
85MP0003123_paternal_imprinting0.96716474
86MP0006072_abnormal_retinal_apoptosis0.95224164
87MP0000015_abnormal_ear_pigmentation0.95194107
88MP0002751_abnormal_autonomic_nervous0.95135156
89MP0001919_abnormal_reproductive_system0.94517897
90MP0001529_abnormal_vocalization0.92395130
91MP0002229_neurodegeneration0.92283824
92MP0003631_nervous_system_phenotype0.91645703
93MP0002837_dystrophic_cardiac_calcinosis0.90963261
94MP0005220_abnormal_exocrine_pancreas0.90113787
95MP0005253_abnormal_eye_physiology0.89499849
96MP0005310_abnormal_salivary_gland0.89265487
97MP0009703_decreased_birth_body0.87340367
98MP0004742_abnormal_vestibular_system0.86743325
99MP0002069_abnormal_eating/drinking_beha0.85038942
100MP0003136_yellow_coat_color0.84952369
101MP0004142_abnormal_muscle_tone0.84481994
102MP0003890_abnormal_embryonic-extraembry0.84372359
103MP0004381_abnormal_hair_follicle0.84248679
104MP0003221_abnormal_cardiomyocyte_apopto0.84210853
105MP0000678_abnormal_parathyroid_gland0.83992187
106MP0002928_abnormal_bile_duct0.83124432
107MP0009697_abnormal_copulation0.82251222
108MP0000920_abnormal_myelination0.82139130
109* MP0004085_abnormal_heartbeat0.81990675
110MP0001905_abnormal_dopamine_level0.79983985
111MP0009115_abnormal_fat_cell0.79335586
112MP0004084_abnormal_cardiac_muscle0.78277591
113MP0005174_abnormal_tail_pigmentation0.78249352
114MP0003828_pulmonary_edema0.78119921
115MP0003195_calcinosis0.74548207
116MP0004233_abnormal_muscle_weight0.74033694
117MP0010678_abnormal_skin_adnexa0.73118698
118MP0000383_abnormal_hair_follicle0.73057592
119* MP0002752_abnormal_somatic_nervous0.72544206
120MP0003172_abnormal_lysosome_physiology0.72278941
121MP0005367_renal/urinary_system_phenotyp0.71863563
122MP0000516_abnormal_urinary_system0.71863563
123MP0002006_tumorigenesis0.70304883
124MP0001348_abnormal_lacrimal_gland0.69874781
125MP0001944_abnormal_pancreas_morphology0.69352489
126MP0003567_abnormal_fetal_cardiomyocyte0.69074612
127MP0002653_abnormal_ependyma_morphology0.68998083
128* MP0000703_abnormal_thymus_morphology0.68473973
129MP0003698_abnormal_male_reproductive0.67830387
130MP0001485_abnormal_pinna_reflex0.66398056
131MP0000026_abnormal_inner_ear0.65253673
132MP0008789_abnormal_olfactory_epithelium0.65175502
133MP0003868_abnormal_feces_composition0.64760347
134MP0003632_abnormal_nervous_system0.64027818
135MP0005379_endocrine/exocrine_gland_phen0.62413575
136MP0001943_abnormal_respiration0.60814841
137* MP0002082_postnatal_lethality0.59983830
138* MP0010770_preweaning_lethality0.59983830
139MP0001664_abnormal_digestion0.57068285
140MP0002693_abnormal_pancreas_physiology0.56124993
141* MP0010769_abnormal_survival0.53889127
142MP0004484_altered_response_of0.53461455

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.20070964
2Febrile seizures (HP:0002373)5.72976495
3Atonic seizures (HP:0010819)5.64264660
4Epileptic encephalopathy (HP:0200134)5.58982452
5Hyperventilation (HP:0002883)4.87481215
6Focal seizures (HP:0007359)4.67290868
7Absence seizures (HP:0002121)4.10488065
8Progressive cerebellar ataxia (HP:0002073)4.01377930
9Protruding tongue (HP:0010808)3.91811802
10Dialeptic seizures (HP:0011146)3.71844185
11Abnormal hair whorl (HP:0010721)3.61716933
12Broad-based gait (HP:0002136)3.51848336
13Abnormality of the fingertips (HP:0001211)3.49729803
14Gaze-evoked nystagmus (HP:0000640)3.44811963
15Blue irides (HP:0000635)3.23665535
16Generalized tonic-clonic seizures (HP:0002069)3.14042459
17Acute myeloid leukemia (HP:0004808)3.05645373
18Drooling (HP:0002307)3.03715899
19Excessive salivation (HP:0003781)3.03715899
20Gait imbalance (HP:0002141)3.03714977
21Visual hallucinations (HP:0002367)3.03423403
22Myokymia (HP:0002411)3.02201992
23Heterotopia (HP:0002282)2.91305807
24Epileptiform EEG discharges (HP:0011182)2.90502914
25Congenital primary aphakia (HP:0007707)2.88856663
26Truncal ataxia (HP:0002078)2.87875241
27Medial flaring of the eyebrow (HP:0010747)2.85701978
28Menstrual irregularities (HP:0000858)2.78512149
29Nephrogenic diabetes insipidus (HP:0009806)2.76114377
30Papillary thyroid carcinoma (HP:0002895)2.73503249
31Macroorchidism (HP:0000053)2.71611470
32Genetic anticipation (HP:0003743)2.71028825
33Short chin (HP:0000331)2.65424960
34Impaired smooth pursuit (HP:0007772)2.64318530
35Truncal obesity (HP:0001956)2.60113743
36Genital tract atresia (HP:0001827)2.56682700
37EEG with generalized epileptiform discharges (HP:0011198)2.55781363
38Vaginal atresia (HP:0000148)2.55370375
39Dysmetric saccades (HP:0000641)2.54393063
40Absent speech (HP:0001344)2.53830580
41Papilledema (HP:0001085)2.46337272
42Volvulus (HP:0002580)2.45596519
43Poor coordination (HP:0002370)2.44006570
44Generalized hypopigmentation of hair (HP:0011358)2.34934009
45Hypsarrhythmia (HP:0002521)2.34691366
46Pheochromocytoma (HP:0002666)2.34686141
47Poor eye contact (HP:0000817)2.32805434
48Dysdiadochokinesis (HP:0002075)2.32758331
49Tubulointerstitial nephritis (HP:0001970)2.29574628
50Subacute progressive viral hepatitis (HP:0006572)2.26072716
51Amblyopia (HP:0000646)2.23280696
52Hypoplastic iliac wings (HP:0002866)2.21399009
53Thyroiditis (HP:0100646)2.20989627
54Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.19957472
55Impaired vibration sensation in the lower limbs (HP:0002166)2.18879043
56Scanning speech (HP:0002168)2.18583974
57Urinary bladder sphincter dysfunction (HP:0002839)2.18344651
58Depression (HP:0000716)2.17934675
59Widely spaced teeth (HP:0000687)2.17007424
60Abnormality of the corticospinal tract (HP:0002492)2.16407066
61Abnormality of salivation (HP:0100755)2.16047885
62Fair hair (HP:0002286)2.15071093
63Narrow palate (HP:0000189)2.14868741
64Abnormality of ocular smooth pursuit (HP:0000617)2.13647984
65Degeneration of the lateral corticospinal tracts (HP:0002314)2.12983841
66Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.12983841
67Hyperkalemia (HP:0002153)2.10662045
68Abnormal social behavior (HP:0012433)2.08091750
69Impaired social interactions (HP:0000735)2.08091750
70Abnormality of the nasal septum (HP:0000419)2.06737580
71Action tremor (HP:0002345)2.05883312
72Abnormality of the labia minora (HP:0012880)2.04877320
73Specific learning disability (HP:0001328)2.04129235
74Hypothermia (HP:0002045)2.02985245
75Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.02839192
76Thyroid carcinoma (HP:0002890)1.99691818
77Tapered finger (HP:0001182)1.97837171
78Failure to thrive in infancy (HP:0001531)1.97022799
79Inappropriate behavior (HP:0000719)1.96988740
80Prominent nose (HP:0000448)1.95809403
81Sandal gap (HP:0001852)1.93157081
82Stomach cancer (HP:0012126)1.92795611
83Transitional cell carcinoma of the bladder (HP:0006740)1.91426891
84Abnormal eating behavior (HP:0100738)1.91128270
85Neuroendocrine neoplasm (HP:0100634)1.89991226
86Agitation (HP:0000713)1.89290909
87Acanthocytosis (HP:0001927)1.88906826
88Anxiety (HP:0000739)1.88355102
89Autoimmune hemolytic anemia (HP:0001890)1.88192364
90Impaired vibratory sensation (HP:0002495)1.87699619
91Hyperthyroidism (HP:0000836)1.86539832
92Midline defect of the nose (HP:0004122)1.86205480
93Bladder neoplasm (HP:0009725)1.85627958
94Bladder carcinoma (HP:0002862)1.85627958
95Bradykinesia (HP:0002067)1.85183045
96Abnormality of chromosome segregation (HP:0002916)1.85033176
97Chronic hepatic failure (HP:0100626)1.84713581
98* Stereotypic behavior (HP:0000733)1.84118945
99Neonatal hypoglycemia (HP:0001998)1.84038968
100Inability to walk (HP:0002540)1.83860280
101Bifid tongue (HP:0010297)1.83703847
102Central scotoma (HP:0000603)1.83190984
103Labial hypoplasia (HP:0000066)1.82685726
104Postural instability (HP:0002172)1.82676417
105Aplasia/Hypoplasia of the lens (HP:0008063)1.82409942
106Amyotrophic lateral sclerosis (HP:0007354)1.81575300
107Hypoplastic labia majora (HP:0000059)1.80471617
108Narrow nasal bridge (HP:0000446)1.78189062
109Spastic gait (HP:0002064)1.77246158
110* Gastroesophageal reflux (HP:0002020)1.77169728
111Dysmetria (HP:0001310)1.75977848
112Hepatoblastoma (HP:0002884)1.75357241
113Resting tremor (HP:0002322)1.74597374
114Aqueductal stenosis (HP:0002410)1.74323675
115Gonadotropin excess (HP:0000837)1.73363794
116Overgrowth (HP:0001548)1.72622395
117Diplopia (HP:0000651)1.71710738
118Abnormality of binocular vision (HP:0011514)1.71710738
119Obsessive-compulsive behavior (HP:0000722)1.70851247
120Cutaneous finger syndactyly (HP:0010554)1.70618420
121Lower limb muscle weakness (HP:0007340)1.70287321
122Neoplasm of the oral cavity (HP:0100649)1.69381904
123* Cystic hygroma (HP:0000476)1.68764979
124Sporadic (HP:0003745)1.68082406
125Abnormality of incisor morphology (HP:0011063)1.67457035
126* Absent eyebrow (HP:0002223)1.67370363
127Hypoplastic female external genitalia (HP:0012815)1.67064754
128Congenital stationary night blindness (HP:0007642)1.66493439
129Exotropia (HP:0000577)1.65059103
130Pancreatic fibrosis (HP:0100732)1.64507729
131Cupped ear (HP:0000378)1.64494579
132Heterochromia iridis (HP:0001100)1.64402436
133Intestinal atresia (HP:0011100)1.64200381
134True hermaphroditism (HP:0010459)1.63986424
135Deeply set eye (HP:0000490)1.63411837
136Abnormality of the labia majora (HP:0012881)1.62665419
137Subaortic stenosis (HP:0001682)1.62260710
138Abnormality of the left ventricular outflow tract (HP:0011103)1.62260710
139Molar tooth sign on MRI (HP:0002419)1.61393486
140Abnormality of midbrain morphology (HP:0002418)1.61393486
141Sensory axonal neuropathy (HP:0003390)1.60860989
142Poikilocytosis (HP:0004447)1.60458746
143* Open mouth (HP:0000194)1.60131535
144Macroglossia (HP:0000158)1.60056580
145Ankle clonus (HP:0011448)1.59310724
146Polyphagia (HP:0002591)1.59112058
147Megalencephaly (HP:0001355)1.58896353
148Stomatitis (HP:0010280)1.58006229
149Hypoplasia of the maxilla (HP:0000327)1.57914543
150Autism (HP:0000717)1.57599187
151Short foot (HP:0001773)1.57252164
152* Cubitus valgus (HP:0002967)1.57223172
153Progressive inability to walk (HP:0002505)1.57071511
154* Deep palmar crease (HP:0006191)1.54688526
155Hyperinsulinemic hypoglycemia (HP:0000825)1.54652919

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.27610430
2NTRK34.05352520
3MAP2K73.22942833
4EPHA43.22150466
5MAP3K42.97963723
6PRPF4B2.92668493
7PLK22.51990774
8DAPK22.40005625
9MAP3K122.13643086
10NLK2.02444932
11MARK12.00073020
12CDK121.90529253
13PRKD31.83221491
14* SGK21.82362409
15DAPK11.75259574
16MAPK131.71567866
17EPHA31.66646605
18MINK11.66135423
19MAP2K41.65861184
20SIK31.63664887
21FGFR31.58458294
22BMPR21.54510925
23CDK191.48373873
24ERBB31.47797936
25NTRK21.45504792
26INSRR1.43901059
27CCNB11.43528268
28CAMK1D1.40444418
29LATS11.37808420
30PIK3CG1.37109352
31IRAK11.37096990
32MAP3K91.35440633
33* SGK4941.31321532
34* SGK2231.31321532
35TNIK1.30191870
36IRAK41.25534190
37CAMKK21.24852012
38FRK1.24714123
39* SGK31.19756356
40YES11.15640685
41PRKCG1.11906735
42OXSR11.10857190
43CDK51.10372495
44DYRK31.09125446
45RIPK41.06624580
46TAOK31.02785854
47EIF2AK31.02577100
48KSR11.00399937
49TSSK60.99317912
50CAMK2A0.98077527
51PRKCH0.97427066
52PRKCE0.97137545
53NEK60.96959592
54HIPK20.96890663
55CAMKK10.94877168
56IRAK20.92148917
57MAP3K20.92029240
58BCR0.91856070
59KSR20.91709058
60ACVR1B0.91555333
61CAMK2B0.89912300
62STK38L0.89866002
63CDK30.88474067
64MARK20.88173736
65* SGK10.87392290
66FGFR20.85566174
67MKNK20.83721358
68GRK50.81409651
69TEC0.79353948
70PAK60.77647491
71JAK10.75291672
72BRSK20.74608277
73RPS6KB10.74560172
74PDGFRB0.72308100
75WNK30.72171303
76BRD40.71767154
77DYRK1A0.69823181
78PTK2B0.68928526
79RPS6KA20.68421211
80RET0.67820150
81TYRO30.67261321
82TAF10.67170035
83WNK10.65293979
84JAK20.64935362
85RAF10.63430800
86UHMK10.61438287
87PLK30.61314041
88CAMK10.59836278
89MARK30.59593394
90CAMK40.59223841
91STK30.59018440
92NTRK10.58315949
93BMPR1B0.57893340
94MAP3K60.56173042
95TNK20.56123037
96CDC42BPA0.56090927
97HCK0.55108898
98CAMK2D0.53899875
99BTK0.53097592
100STK380.52618685
101ADRBK10.52128371
102MAPK70.51304321
103FER0.51058529
104ZAK0.48703168
105MAP3K140.47321523
106FES0.46392587
107ITK0.46064002
108TRPM70.45823815
109PRKAA10.44443751
110PDK10.44310054
111PINK10.44246473
112IKBKE0.44133568
113PAK30.43956369
114CDK180.43662317
115* RPS6KA30.43089801
116PNCK0.42119578
117MAP3K70.42076701
118ATM0.40959617
119CHUK0.40870106
120STK240.40774144
121MAP3K10.40613530
122EEF2K0.40564259
123MKNK10.40436504
124PLK40.40377143
125CSNK1A1L0.40366749
126* PRKCB0.40171986
127CDK80.39863435
128MAPK100.39566188
129FGFR10.39565897
130NUAK10.39404636
131CDK60.39330874
132STK110.38967649
133SIK20.38753589
134CDK140.34729573
135ERBB40.34484989
136ADRBK20.34456370
137CSNK1A10.33049301
138CDK150.32900648
139CAMK1G0.32441582
140GSK3B0.31736692
141* PRKACA0.31714551
142PRKCZ0.31553713
143* PRKG10.30244504
144CAMK2G0.29900880
145GRK70.28985478
146PDK40.28931846
147PDK30.28931846
148MAP3K130.28908651

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.03232865
2Synaptic vesicle cycle_Homo sapiens_hsa047213.47812965
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.81099918
4Olfactory transduction_Homo sapiens_hsa047402.71900884
5Morphine addiction_Homo sapiens_hsa050322.67206915
6Circadian entrainment_Homo sapiens_hsa047132.64013391
7GABAergic synapse_Homo sapiens_hsa047272.61000001
8Amphetamine addiction_Homo sapiens_hsa050312.49611721
9* Long-term potentiation_Homo sapiens_hsa047202.48057075
10Glutamatergic synapse_Homo sapiens_hsa047242.32572300
11Insulin secretion_Homo sapiens_hsa049112.30115978
12Collecting duct acid secretion_Homo sapiens_hsa049662.29337236
13Dopaminergic synapse_Homo sapiens_hsa047282.14061071
14Taste transduction_Homo sapiens_hsa047422.05752327
15Phototransduction_Homo sapiens_hsa047441.99754018
16Salivary secretion_Homo sapiens_hsa049701.74603015
17Cholinergic synapse_Homo sapiens_hsa047251.73988577
18* Serotonergic synapse_Homo sapiens_hsa047261.73093313
19Vibrio cholerae infection_Homo sapiens_hsa051101.68651395
20Renin secretion_Homo sapiens_hsa049241.63709534
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60343861
22Cocaine addiction_Homo sapiens_hsa050301.54992270
23Calcium signaling pathway_Homo sapiens_hsa040201.51242497
24* Long-term depression_Homo sapiens_hsa047301.49910194
25Type II diabetes mellitus_Homo sapiens_hsa049301.49349949
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.42754602
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.40828984
28* Non-small cell lung cancer_Homo sapiens_hsa052231.37670919
29Oxytocin signaling pathway_Homo sapiens_hsa049211.35586498
30Gastric acid secretion_Homo sapiens_hsa049711.35165835
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.31847816
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.24920583
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24221632
34Type I diabetes mellitus_Homo sapiens_hsa049401.22939141
35T cell receptor signaling pathway_Homo sapiens_hsa046601.22468154
36Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.22042288
37* cAMP signaling pathway_Homo sapiens_hsa040241.20327623
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16975230
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16726693
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15454534
41* Colorectal cancer_Homo sapiens_hsa052101.15373259
42* Prostate cancer_Homo sapiens_hsa052151.15280382
43B cell receptor signaling pathway_Homo sapiens_hsa046621.14992884
44* Chronic myeloid leukemia_Homo sapiens_hsa052201.08855901
45NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08184840
46* Renal cell carcinoma_Homo sapiens_hsa052111.08131761
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07987994
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07954885
49Melanogenesis_Homo sapiens_hsa049161.04883499
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04831801
51Axon guidance_Homo sapiens_hsa043601.04804107
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04769358
53* ErbB signaling pathway_Homo sapiens_hsa040121.03544938
54Circadian rhythm_Homo sapiens_hsa047101.02804405
55Gap junction_Homo sapiens_hsa045401.02665134
56GnRH signaling pathway_Homo sapiens_hsa049121.02177724
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99413383
58Jak-STAT signaling pathway_Homo sapiens_hsa046300.96974619
59Platelet activation_Homo sapiens_hsa046110.96603310
60* Pancreatic cancer_Homo sapiens_hsa052120.96389517
61* Acute myeloid leukemia_Homo sapiens_hsa052210.95955611
62Hepatitis B_Homo sapiens_hsa051610.90768422
63VEGF signaling pathway_Homo sapiens_hsa043700.90039149
64Measles_Homo sapiens_hsa051620.88604571
65Estrogen signaling pathway_Homo sapiens_hsa049150.88148768
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87874160
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87343464
68Osteoclast differentiation_Homo sapiens_hsa043800.86679533
69MicroRNAs in cancer_Homo sapiens_hsa052060.84499654
70* MAPK signaling pathway_Homo sapiens_hsa040100.83939872
71Fatty acid biosynthesis_Homo sapiens_hsa000610.79426334
72* Vascular smooth muscle contraction_Homo sapiens_hsa042700.78404700
73* Glioma_Homo sapiens_hsa052140.78381597
74TNF signaling pathway_Homo sapiens_hsa046680.76761457
75Rheumatoid arthritis_Homo sapiens_hsa053230.74733211
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74648678
77Lysine degradation_Homo sapiens_hsa003100.74044072
78Insulin resistance_Homo sapiens_hsa049310.71934477
79Inositol phosphate metabolism_Homo sapiens_hsa005620.70860490
80Dilated cardiomyopathy_Homo sapiens_hsa054140.68418730
81Wnt signaling pathway_Homo sapiens_hsa043100.67315221
82* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66810141
83Thyroid hormone synthesis_Homo sapiens_hsa049180.66582467
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66462160
85Pancreatic secretion_Homo sapiens_hsa049720.66355388
86Glucagon signaling pathway_Homo sapiens_hsa049220.65632231
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64825742
88Ras signaling pathway_Homo sapiens_hsa040140.64423195
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64132181
90Oocyte meiosis_Homo sapiens_hsa041140.63394778
91ABC transporters_Homo sapiens_hsa020100.63073878
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63011414
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61708599
94Dorso-ventral axis formation_Homo sapiens_hsa043200.60564790
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60135062
96Adherens junction_Homo sapiens_hsa045200.57558836
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.56200491
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55773116
99mRNA surveillance pathway_Homo sapiens_hsa030150.54332442
100HIF-1 signaling pathway_Homo sapiens_hsa040660.53483626
101Choline metabolism in cancer_Homo sapiens_hsa052310.52777628
102Phagosome_Homo sapiens_hsa041450.52776699
103* Alcoholism_Homo sapiens_hsa050340.52668978
104* Neurotrophin signaling pathway_Homo sapiens_hsa047220.51111121
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51040601
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50156445
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50116952
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47970615
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46663426
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46037467
111* Rap1 signaling pathway_Homo sapiens_hsa040150.44986857
112* Endometrial cancer_Homo sapiens_hsa052130.44846652
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44003669
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41027607
115* Melanoma_Homo sapiens_hsa052180.40752957
116Hedgehog signaling pathway_Homo sapiens_hsa043400.38963325
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.38298411
118Ovarian steroidogenesis_Homo sapiens_hsa049130.38177834
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37324729
120African trypanosomiasis_Homo sapiens_hsa051430.35742301
121Prolactin signaling pathway_Homo sapiens_hsa049170.35560488
122* Insulin signaling pathway_Homo sapiens_hsa049100.31005354
123* mTOR signaling pathway_Homo sapiens_hsa041500.30983024
124Regulation of autophagy_Homo sapiens_hsa041400.30009959
125* FoxO signaling pathway_Homo sapiens_hsa040680.25518984
126* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24957398
127Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.24854258
128* Chemokine signaling pathway_Homo sapiens_hsa040620.24417063
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.24257826
130Cardiac muscle contraction_Homo sapiens_hsa042600.23852753
131Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.22878350
132Endocytosis_Homo sapiens_hsa041440.21712683
133N-Glycan biosynthesis_Homo sapiens_hsa005100.17961864

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