ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	limb bud formation (GO:0060174)	6.35624735
2	respiratory chain complex IV assembly (GO:0008535)	4.50900082
3	cornea development in camera-type eye (GO:0061303)	4.22683496
4	response to pheromone (GO:0019236)	3.98090736
5	cytochrome complex assembly (GO:0017004)	3.90546066
6	platelet dense granule organization (GO:0060155)	3.82521586
7	lactate metabolic process (GO:0006089)	3.71721216
8	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.71559234
9	glycerophospholipid catabolic process (GO:0046475)	3.69640597
10	replication fork processing (GO:0031297)	3.54861957
11	nonmotile primary cilium assembly (GO:0035058)	3.49482241
12	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.41621484
13	regulation of hippo signaling (GO:0035330)	3.37021832
14	L-fucose catabolic process (GO:0042355)	3.19217207
15	fucose catabolic process (GO:0019317)	3.19217207
16	L-fucose metabolic process (GO:0042354)	3.19217207
17	behavioral response to nicotine (GO:0035095)	3.15848932
18	signal peptide processing (GO:0006465)	3.13274230
19	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.09824461
20	histone H2A acetylation (GO:0043968)	3.09549376
21	negative regulation of execution phase of apoptosis (GO:1900118)	3.09178805
22	positive regulation of immune response to tumor cell (GO:0002839)	3.05338201
23	regulation of immune response to tumor cell (GO:0002837)	3.05338201
24	regulation of response to tumor cell (GO:0002834)	3.05338201
25	positive regulation of response to tumor cell (GO:0002836)	3.05338201
26	regulation of glucokinase activity (GO:0033131)	3.04679059
27	regulation of hexokinase activity (GO:1903299)	3.04679059
28	xenobiotic catabolic process (GO:0042178)	3.02397224
29	protein K11-linked deubiquitination (GO:0035871)	3.01641755
30	detection of light stimulus involved in sensory perception (GO:0050962)	3.01375141
31	detection of light stimulus involved in visual perception (GO:0050908)	3.01375141
32	photoreceptor cell maintenance (GO:0045494)	3.00935540
33	auditory receptor cell stereocilium organization (GO:0060088)	2.99594311
34	transepithelial transport (GO:0070633)	2.96910460
35	neural tube formation (GO:0001841)	2.93404857
36	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.93247635
37	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.91179606
38	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.91179606
39	regulation of translation, ncRNA-mediated (GO:0045974)	2.91179606
40	phospholipid homeostasis (GO:0055091)	2.90417056
41	glial cell proliferation (GO:0014009)	2.88692721
42	negative regulation of T-helper cell differentiation (GO:0045623)	2.88325686
43	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.88325686
44	reflex (GO:0060004)	2.88141713
45	keratinocyte development (GO:0003334)	2.83348262
46	water-soluble vitamin biosynthetic process (GO:0042364)	2.78633755
47	prenylation (GO:0097354)	2.75810947
48	protein prenylation (GO:0018342)	2.75810947
49	negative regulation of neurological system process (GO:0031645)	2.75256051
50	DNA deamination (GO:0045006)	2.73533626
51	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.71895589
52	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.69875127
53	regulation of meiosis I (GO:0060631)	2.69315397
54	negative regulation of alpha-beta T cell differentiation (GO:0046639)	2.69290403
55	pharyngeal system development (GO:0060037)	2.69144446
56	activated T cell proliferation (GO:0050798)	2.68394565
57	regulation of neuron projection regeneration (GO:0070570)	2.67449925
58	regulation of axon regeneration (GO:0048679)	2.67449925
59	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.66920259
60	retinal cone cell development (GO:0046549)	2.65152323
61	female gonad development (GO:0008585)	2.64372796
62	peptidyl-histidine modification (GO:0018202)	2.63286508
63	righting reflex (GO:0060013)	2.62963271
64	centriole replication (GO:0007099)	2.62021184
65	response to nitrosative stress (GO:0051409)	2.61139816
66	indole-containing compound catabolic process (GO:0042436)	2.60778371
67	indolalkylamine catabolic process (GO:0046218)	2.60778371
68	tryptophan catabolic process (GO:0006569)	2.60778371
69	fatty acid transmembrane transport (GO:1902001)	2.58314372
70	cullin deneddylation (GO:0010388)	2.56947009
71	C-terminal protein lipidation (GO:0006501)	2.54687421
72	inositol phosphate catabolic process (GO:0071545)	2.54593573
73	mannosylation (GO:0097502)	2.52763248
74	regulation of collateral sprouting (GO:0048670)	2.50314894
75	regulation of heat generation (GO:0031650)	2.50049220
76	nodal signaling pathway (GO:0038092)	2.49058570
77	preassembly of GPI anchor in ER membrane (GO:0016254)	2.48568673
78	sympathetic nervous system development (GO:0048485)	2.48131164
79	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.46979814
80	intraciliary transport (GO:0042073)	2.43754319
81	regulation of transmission of nerve impulse (GO:0051969)	2.42920634
82	protein complex biogenesis (GO:0070271)	2.42589707
83	cilium organization (GO:0044782)	2.41290560
84	protein K6-linked ubiquitination (GO:0085020)	2.40949742
85	DNA double-strand break processing (GO:0000729)	2.39237920
86	neurotransmitter-gated ion channel clustering (GO:0072578)	2.38801945
87	adenosine metabolic process (GO:0046085)	2.38732650
88	branched-chain amino acid catabolic process (GO:0009083)	2.38342730
89	C-terminal protein amino acid modification (GO:0018410)	2.36652771
90	necroptotic process (GO:0070266)	2.34784015
91	cilium assembly (GO:0042384)	2.34653543
92	recombinational repair (GO:0000725)	2.33759597
93	double-strand break repair via homologous recombination (GO:0000724)	2.33652230
94	embryonic epithelial tube formation (GO:0001838)	2.32871578
95	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.32686337
96	inner ear receptor stereocilium organization (GO:0060122)	2.30453243
97	proteasome assembly (GO:0043248)	2.30363447
98	mitochondrial respiratory chain complex assembly (GO:0033108)	2.30303269
99	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.28968769
100	renal tubule morphogenesis (GO:0061333)	2.28526300

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.24718025
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.01409982
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.96579445
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.89754970
5	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.88321005
6	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.77968597
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.71793159
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.60840299
9	VDR_22108803_ChIP-Seq_LS180_Human	2.59056745
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.30109066
11	FUS_26573619_Chip-Seq_HEK293_Human	2.23736819
12	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.23400856
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.20341254
14	P300_19829295_ChIP-Seq_ESCs_Human	2.16826271
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.14141405
16	EWS_26573619_Chip-Seq_HEK293_Human	2.04393989
17	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.03868918
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.96846177
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.96111191
20	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.94066273
21	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.93862328
22	BCAT_22108803_ChIP-Seq_LS180_Human	1.92988262
23	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.92412062
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.88605887
25	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.79834930
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.75755754
27	ELK1_19687146_ChIP-ChIP_HELA_Human	1.74264411
28	TAF15_26573619_Chip-Seq_HEK293_Human	1.72208214
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.71162628
30	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.63858224
31	SMAD4_21799915_ChIP-Seq_A2780_Human	1.61933041
32	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.61927591
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.61616075
34	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.60932598
35	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.59984361
36	TCF4_22108803_ChIP-Seq_LS180_Human	1.57571597
37	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.53481684
38	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.51371346
39	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.51180341
40	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.51092112
41	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.50787420
42	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.49942195
43	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.47956300
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.46893859
45	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.46893859
46	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.45448956
47	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.45345158
48	STAT3_23295773_ChIP-Seq_U87_Human	1.44601210
49	AR_25329375_ChIP-Seq_VCAP_Human	1.44130396
50	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.42594083
51	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.40242254
52	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.39980129
53	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.39575240
54	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.37129441
55	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.36948038
56	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.35584233
57	TCF4_23295773_ChIP-Seq_U87_Human	1.34919453
58	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.34751516
59	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.32251169
60	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31788330
61	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31788330
62	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.27505565
63	TP53_22573176_ChIP-Seq_HFKS_Human	1.26372861
64	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.25673357
65	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.24589735
66	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.24501893
67	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.24253406
68	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.23860460
69	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.22185881
70	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.22185881
71	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.19201052
72	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.17586370
73	CDX2_22108803_ChIP-Seq_LS180_Human	1.17311439
74	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.17242977
75	HTT_18923047_ChIP-ChIP_STHdh_Human	1.17034563
76	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.16299309
77	RUNX2_22187159_ChIP-Seq_PCA_Human	1.16184495
78	MYC_18940864_ChIP-ChIP_HL60_Human	1.14033413
79	P53_22387025_ChIP-Seq_ESCs_Mouse	1.12704222
80	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.11956710
81	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.10349282
82	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.10301614
83	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.09974115
84	P300_18555785_Chip-Seq_ESCs_Mouse	1.09843383
85	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.09319165
86	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.09308216
87	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.09004875
88	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.07773650
89	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.06410064
90	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.05623458
91	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.04642767
92	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.04642767
93	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.03570645
94	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.02806874
95	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.01140858
96	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.01117811
97	HOXB7_26014856_ChIP-Seq_BT474_Human	1.00534109
98	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.99850923
99	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.99835774
100	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.99102682

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005379_endocrine/exocrine_gland_phen	4.23972895
2	MP0002163_abnormal_gland_morphology	3.90187579
3	MP0000569_abnormal_digit_pigmentation	3.49652971
4	MP0002254_reproductive_system_inflammat	3.31954365
5	MP0003195_calcinosis	2.91343845
6	MP0002876_abnormal_thyroid_physiology	2.45476187
7	MP0002736_abnormal_nociception_after	2.40170779
8	MP0002837_dystrophic_cardiac_calcinosis	2.36598772
9	MP0005367_renal/urinary_system_phenotyp	2.26152117
10	MP0000516_abnormal_urinary_system	2.26152117
11	MP0001348_abnormal_lacrimal_gland	2.22737881
12	MP0001968_abnormal_touch/_nociception	2.19824159
13	MP0005075_abnormal_melanosome_morpholog	2.19587183
14	MP0008872_abnormal_physiological_respon	2.17427713
15	MP0008877_abnormal_DNA_methylation	2.14314519
16	MP0002102_abnormal_ear_morphology	2.11971102
17	MP0000372_irregular_coat_pigmentation	2.11656660
18	MP0005551_abnormal_eye_electrophysiolog	2.10620555
19	MP0002138_abnormal_hepatobiliary_system	2.04409929
20	MP0002938_white_spotting	2.03405367
21	MP0000427_abnormal_hair_cycle	2.01098990
22	MP0005408_hypopigmentation	1.87046486
23	MP0003943_abnormal_hepatobiliary_system	1.73917582
24	MP0006082_CNS_inflammation	1.72466199
25	MP0004742_abnormal_vestibular_system	1.70049000
26	MP0005253_abnormal_eye_physiology	1.69689723
27	MP0006072_abnormal_retinal_apoptosis	1.66783448
28	MP0002751_abnormal_autonomic_nervous	1.64355028
29	MP0003283_abnormal_digestive_organ	1.61286077
30	MP0003011_delayed_dark_adaptation	1.56346865
31	MP0003252_abnormal_bile_duct	1.56329719
32	MP0010386_abnormal_urinary_bladder	1.46556795
33	MP0005645_abnormal_hypothalamus_physiol	1.44159217
34	MP0000383_abnormal_hair_follicle	1.43728680
35	MP0000647_abnormal_sebaceous_gland	1.39129637
36	MP0000613_abnormal_salivary_gland	1.35092468
37	MP0004885_abnormal_endolymph	1.34905596
38	MP0008057_abnormal_DNA_replication	1.32645177
39	MP0008875_abnormal_xenobiotic_pharmacok	1.30649503
40	MP0004043_abnormal_pH_regulation	1.28356965
41	MP0005310_abnormal_salivary_gland	1.27608764
42	MP0001986_abnormal_taste_sensitivity	1.26067909
43	MP0004142_abnormal_muscle_tone	1.25028731
44	MP0002735_abnormal_chemical_nociception	1.25004387
45	MP0005174_abnormal_tail_pigmentation	1.24342408
46	MP0003718_maternal_effect	1.23301178
47	MP0005220_abnormal_exocrine_pancreas	1.21815890
48	MP0003787_abnormal_imprinting	1.19884520
49	MP0005646_abnormal_pituitary_gland	1.17968758
50	MP0004270_analgesia	1.17198107
51	MP0004215_abnormal_myocardial_fiber	1.13877692
52	MP0002928_abnormal_bile_duct	1.10831750
53	MP0001485_abnormal_pinna_reflex	1.08243240
54	MP0002277_abnormal_respiratory_mucosa	1.07433040
55	MP0004133_heterotaxia	1.07241026
56	MP0004145_abnormal_muscle_electrophysio	1.05680536
57	MP0002272_abnormal_nervous_system	1.05212469
58	MP0002168_other_aberrant_phenotype	1.04354240
59	MP0008058_abnormal_DNA_repair	1.03488656
60	MP0003880_abnormal_central_pattern	1.03056696
61	MP0005395_other_phenotype	1.01659153
62	MP0001486_abnormal_startle_reflex	1.00723169
63	MP0010678_abnormal_skin_adnexa	1.00692947
64	MP0005670_abnormal_white_adipose	1.00263255
65	MP0005332_abnormal_amino_acid	0.99473152
66	MP0009745_abnormal_behavioral_response	0.98955301
67	MP0000631_abnormal_neuroendocrine_gland	0.98654983
68	MP0009046_muscle_twitch	0.97381522
69	MP0003806_abnormal_nucleotide_metabolis	0.95692113
70	MP0004381_abnormal_hair_follicle	0.94946977
71	MP0003045_fibrosis	0.93680097
72	MP0003186_abnormal_redox_activity	0.93092321
73	MP0001764_abnormal_homeostasis	0.92022177
74	MP0001984_abnormal_olfaction	0.90685179
75	MP0000639_abnormal_adrenal_gland	0.90571689
76	MP0004085_abnormal_heartbeat	0.90430640
77	MP0001501_abnormal_sleep_pattern	0.90272723
78	MP0005187_abnormal_penis_morphology	0.89302482
79	MP0003950_abnormal_plasma_membrane	0.88514236
80	MP0001346_abnormal_lacrimal_gland	0.86420915
81	MP0009780_abnormal_chondrocyte_physiolo	0.86258154
82	MP0005167_abnormal_blood-brain_barrier	0.85462141
83	MP0002638_abnormal_pupillary_reflex	0.85086499
84	MP0005084_abnormal_gallbladder_morpholo	0.82075187
85	MP0002734_abnormal_mechanical_nocicepti	0.81751115
86	MP0000538_abnormal_urinary_bladder	0.80656722
87	MP0001944_abnormal_pancreas_morphology	0.78388293
88	MP0003786_premature_aging	0.76039541
89	MP0001324_abnormal_eye_pigmentation	0.75530988
90	MP0003646_muscle_fatigue	0.74710487
91	MP0001188_hyperpigmentation	0.73597298
92	MP0001756_abnormal_urination	0.73335740
93	MP0000013_abnormal_adipose_tissue	0.73319840
94	MP0005386_behavior/neurological_phenoty	0.72659271
95	MP0004924_abnormal_behavior	0.72659271
96	MP0002139_abnormal_hepatobiliary_system	0.71688394
97	MP0005248_abnormal_Harderian_gland	0.71646286
98	MP0008995_early_reproductive_senescence	0.68713113
99	MP0009697_abnormal_copulation	0.67914333
100	MP0002233_abnormal_nose_morphology	0.67711133

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the labia minora (HP:0012880)	3.72305844
2	Pancreatic cysts (HP:0001737)	3.45756675
3	Hyperventilation (HP:0002883)	3.45166164
4	Abnormality of the renal cortex (HP:0011035)	3.14738583
5	True hermaphroditism (HP:0010459)	3.07490364
6	Medial flaring of the eyebrow (HP:0010747)	2.97318265
7	Short 1st metacarpal (HP:0010034)	2.95656674
8	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.95656674
9	Long clavicles (HP:0000890)	2.93108539
10	Pancreatic fibrosis (HP:0100732)	2.91855834
11	Molar tooth sign on MRI (HP:0002419)	2.68209897
12	Abnormality of midbrain morphology (HP:0002418)	2.68209897
13	Abnormality of macular pigmentation (HP:0008002)	2.63701942
14	Hypoplastic labia majora (HP:0000059)	2.62468853
15	Intestinal atresia (HP:0011100)	2.61823306
16	Abnormality of the 1st metacarpal (HP:0010009)	2.57054579
17	Abnormal biliary tract morphology (HP:0012440)	2.55853180
18	Hypokalemic alkalosis (HP:0001949)	2.46771909
19	Pendular nystagmus (HP:0012043)	2.45798212
20	Aqueductal stenosis (HP:0002410)	2.45701979
21	Metabolic alkalosis (HP:0200114)	2.45143313
22	Progressive macrocephaly (HP:0004481)	2.42478243
23	Renal cortical cysts (HP:0000803)	2.40876270
24	Congenital stationary night blindness (HP:0007642)	2.40008228
25	Abnormality of the anterior horn cell (HP:0006802)	2.38532469
26	Degeneration of anterior horn cells (HP:0002398)	2.38532469
27	Abnormality of the labia majora (HP:0012881)	2.29272283
28	Congenital primary aphakia (HP:0007707)	2.28654630
29	Hepatoblastoma (HP:0002884)	2.26887838
30	Gait imbalance (HP:0002141)	2.26867159
31	Gaze-evoked nystagmus (HP:0000640)	2.24493162
32	Abnormality of the parathyroid morphology (HP:0011766)	2.24086090
33	Labial hypoplasia (HP:0000066)	2.23110083
34	Volvulus (HP:0002580)	2.21939923
35	Abnormality of the renal medulla (HP:0100957)	2.20916596
36	Acute encephalopathy (HP:0006846)	2.20758626
37	Chronic hepatic failure (HP:0100626)	2.17081335
38	Short phalanx of the thumb (HP:0009660)	2.16575439
39	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.16203424
40	Acute necrotizing encephalopathy (HP:0006965)	2.15748679
41	Astrocytoma (HP:0009592)	2.15043921
42	Abnormality of the astrocytes (HP:0100707)	2.15043921
43	Cystic liver disease (HP:0006706)	2.10821794
44	Nephronophthisis (HP:0000090)	2.10608809
45	Abnormality of chloride homeostasis (HP:0011422)	2.09045463
46	Increased density of long bones (HP:0006392)	2.08957128
47	Alacrima (HP:0000522)	2.08221514
48	Sclerocornea (HP:0000647)	2.06839298
49	Barrel-shaped chest (HP:0001552)	2.05376132
50	Increased CSF lactate (HP:0002490)	2.04421105
51	Nephrogenic diabetes insipidus (HP:0009806)	2.03869449
52	Abnormal hair whorl (HP:0010721)	2.03691441
53	Ependymoma (HP:0002888)	2.03492677
54	Thyroiditis (HP:0100646)	2.03269824
55	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.00466334
56	Polyuria (HP:0000103)	2.00329181
57	Pancreatic islet-cell hyperplasia (HP:0004510)	2.00124592
58	Hypoplastic female external genitalia (HP:0012815)	1.99969994
59	Hypothermia (HP:0002045)	1.99622587
60	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.99580466
61	Large for gestational age (HP:0001520)	1.99310111
62	Genital tract atresia (HP:0001827)	1.98373718
63	Widely spaced teeth (HP:0000687)	1.96765071
64	Hamartoma of the eye (HP:0010568)	1.95479039
65	Severe visual impairment (HP:0001141)	1.94615950
66	3-Methylglutaconic aciduria (HP:0003535)	1.94414641
67	Postaxial hand polydactyly (HP:0001162)	1.94175383
68	Abnormal rod and cone electroretinograms (HP:0008323)	1.92178548
69	Vaginal atresia (HP:0000148)	1.91176932
70	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.90073611
71	Decreased lacrimation (HP:0000633)	1.89713735
72	Narrow forehead (HP:0000341)	1.88171674
73	Methylmalonic acidemia (HP:0002912)	1.87730938
74	Furrowed tongue (HP:0000221)	1.87240723
75	Bifid tongue (HP:0010297)	1.86908786
76	Limb hypertonia (HP:0002509)	1.86662721
77	Aplasia/Hypoplasia of the macula (HP:0008059)	1.84543021
78	Abnormality of the nasal septum (HP:0000419)	1.83812240
79	Bicornuate uterus (HP:0000813)	1.82875832
80	Pigmentary retinal degeneration (HP:0001146)	1.82590195
81	Absent eyebrow (HP:0002223)	1.82277931
82	Megalencephaly (HP:0001355)	1.79919841
83	Anencephaly (HP:0002323)	1.79773073
84	Glioma (HP:0009733)	1.78563399
85	Progressive inability to walk (HP:0002505)	1.78466085
86	Oligodactyly (hands) (HP:0001180)	1.77813867
87	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.76472187
88	Hypoplasia of the fovea (HP:0007750)	1.76472187
89	Neoplasm of the adrenal cortex (HP:0100641)	1.76369948
90	Hypoproteinemia (HP:0003075)	1.75705699
91	Increased corneal curvature (HP:0100692)	1.74758741
92	Keratoconus (HP:0000563)	1.74758741
93	Mitochondrial inheritance (HP:0001427)	1.74581977
94	Arthropathy (HP:0003040)	1.74319878
95	Submucous cleft hard palate (HP:0000176)	1.73522246
96	Increased CSF protein (HP:0002922)	1.71599197
97	Spinal muscular atrophy (HP:0007269)	1.71181001
98	Tongue fasciculations (HP:0001308)	1.70042951
99	Febrile seizures (HP:0002373)	1.69569415
100	Aplasia/Hypoplasia affecting the retina (HP:0008061)	1.69106266

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.94665726
2	AKT3	3.83351995
3	FRK	3.81255796
4	TRIM28	3.17220752
5	BRSK2	2.95523189
6	WNK3	2.95252376
7	BCR	2.86062873
8	PINK1	2.70998221
9	LMTK2	2.36089797
10	MST4	2.32643695
11	NUAK1	2.24932897
12	WEE1	2.19607413
13	PBK	2.10853440
14	BMPR1B	1.82547809
15	MKNK2	1.75914430
16	MUSK	1.70502314
17	EIF2AK3	1.69332023
18	FER	1.64038085
19	TNIK	1.63646491
20	ADRBK2	1.60094589
21	MAPK13	1.57367334
22	STK39	1.48222080
23	CASK	1.41139889
24	PAK3	1.33114072
25	PLK3	1.28980421
26	GRK1	1.26444735
27	TSSK6	1.23738500
28	KSR1	1.20798296
29	MARK3	1.19520087
30	MARK1	1.18503419
31	SIK3	1.18242387
32	EPHA3	1.15874767
33	FGFR2	1.15372099
34	SGK2	1.13386856
35	NLK	1.12827943
36	BRSK1	1.09719371
37	WNK4	1.09211790
38	ZAK	1.09016015
39	CAMK1G	1.00510479
40	STK3	0.99710612
41	CAMK1D	0.99318846
42	ACVR1B	0.97451160
43	ERBB3	0.96873143
44	PRKCE	0.92050670
45	PLK2	0.88115261
46	PDK2	0.86722054
47	PRKCI	0.85516496
48	MAP3K12	0.84267920
49	INSRR	0.81357288
50	PTK2B	0.80445666
51	MKNK1	0.79876839
52	EIF2AK1	0.79710778
53	PNCK	0.78430705
54	STK16	0.77750046
55	TAF1	0.71214138
56	DAPK2	0.69584016
57	MAPKAPK3	0.68387540
58	TGFBR2	0.67790527
59	OXSR1	0.66855501
60	TXK	0.65999082
61	STK38L	0.65397295
62	SGK494	0.61163354
63	SGK223	0.61163354
64	SGK3	0.60568348
65	VRK1	0.60282018
66	FGFR1	0.58641602
67	STK24	0.55696935
68	BRD4	0.55436243
69	CSNK1G1	0.54626730
70	SRPK1	0.52250605
71	BCKDK	0.51341410
72	MAPKAPK5	0.50485175
73	CCNB1	0.49194889
74	TGFBR1	0.48509081
75	NME1	0.48278740
76	STK4	0.48019255
77	IRAK1	0.47138758
78	PHKG2	0.46543444
79	PHKG1	0.46543444
80	CSNK1A1L	0.45799379
81	DYRK2	0.43499692
82	EPHB1	0.43052799
83	CSNK1G2	0.40906943
84	FGFR3	0.39114082
85	EIF2AK2	0.38888752
86	TRPM7	0.37151198
87	IKBKB	0.36485767
88	CSNK1G3	0.36108325
89	PRKCQ	0.35732273
90	CSNK1A1	0.35593863
91	PRKAA2	0.35161362
92	ROCK1	0.34618549
93	VRK2	0.33680882
94	BRAF	0.33632517
95	TNK2	0.32677677
96	NEK6	0.31331316
97	PRKCZ	0.30799583
98	CSNK1D	0.29624060
99	GSK3A	0.28395052
100	ATM	0.27976938

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.91474856
2	Non-homologous end-joining_Homo sapiens_hsa03450	2.85443958
3	Propanoate metabolism_Homo sapiens_hsa00640	2.81496869
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.65357776
5	Phototransduction_Homo sapiens_hsa04744	2.45973345
6	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.21501265
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.05064631
8	Nitrogen metabolism_Homo sapiens_hsa00910	1.97905191
9	Homologous recombination_Homo sapiens_hsa03440	1.95990661
10	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.87652363
11	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.80108609
12	Butanoate metabolism_Homo sapiens_hsa00650	1.78059544
13	Basal transcription factors_Homo sapiens_hsa03022	1.77115166
14	Ether lipid metabolism_Homo sapiens_hsa00565	1.75591397
15	Proteasome_Homo sapiens_hsa03050	1.72245277
16	RNA polymerase_Homo sapiens_hsa03020	1.70507657
17	Fatty acid elongation_Homo sapiens_hsa00062	1.58104114
18	Caffeine metabolism_Homo sapiens_hsa00232	1.57455636
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.56711357
20	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.56074373
21	Collecting duct acid secretion_Homo sapiens_hsa04966	1.55321542
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.55180373
23	Oxidative phosphorylation_Homo sapiens_hsa00190	1.50299310
24	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.45616360
25	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.44635228
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.44584068
27	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.43400164
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.40998428
29	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.38639168
30	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.34456159
31	RNA degradation_Homo sapiens_hsa03018	1.34358878
32	Peroxisome_Homo sapiens_hsa04146	1.27033664
33	beta-Alanine metabolism_Homo sapiens_hsa00410	1.25371094
34	Chemical carcinogenesis_Homo sapiens_hsa05204	1.19892343
35	Regulation of autophagy_Homo sapiens_hsa04140	1.18485483
36	Fatty acid metabolism_Homo sapiens_hsa01212	1.17908268
37	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.16210657
38	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.13485288
39	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.12957374
40	Retinol metabolism_Homo sapiens_hsa00830	1.12166327
41	Circadian rhythm_Homo sapiens_hsa04710	1.10840742
42	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.09401099
43	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.08804605
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.08701199
45	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.08597236
46	Sulfur metabolism_Homo sapiens_hsa00920	1.06219350
47	Tryptophan metabolism_Homo sapiens_hsa00380	1.03593743
48	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.03422293
49	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.02294529
50	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.99713939
51	Glutathione metabolism_Homo sapiens_hsa00480	0.98664937
52	Parkinsons disease_Homo sapiens_hsa05012	0.97508549
53	Sphingolipid metabolism_Homo sapiens_hsa00600	0.95031245
54	ABC transporters_Homo sapiens_hsa02010	0.94624920
55	Mismatch repair_Homo sapiens_hsa03430	0.93764452
56	Mineral absorption_Homo sapiens_hsa04978	0.93191124
57	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.89188455
58	Steroid biosynthesis_Homo sapiens_hsa00100	0.85734776
59	Fatty acid degradation_Homo sapiens_hsa00071	0.80299070
60	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.77918204
61	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.77888811
62	Insulin secretion_Homo sapiens_hsa04911	0.77493067
63	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.76066887
64	Purine metabolism_Homo sapiens_hsa00230	0.74355032
65	RNA transport_Homo sapiens_hsa03013	0.72785691
66	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.68680753
67	Metabolic pathways_Homo sapiens_hsa01100	0.68316521
68	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.66205233
69	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.65720734
70	Nucleotide excision repair_Homo sapiens_hsa03420	0.64147936
71	Fat digestion and absorption_Homo sapiens_hsa04975	0.62758805
72	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.62471064
73	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.60996964
74	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.60441860
75	Histidine metabolism_Homo sapiens_hsa00340	0.59933387
76	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.57808896
77	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.56535993
78	One carbon pool by folate_Homo sapiens_hsa00670	0.56315075
79	Nicotine addiction_Homo sapiens_hsa05033	0.55600765
80	Huntingtons disease_Homo sapiens_hsa05016	0.55456992
81	p53 signaling pathway_Homo sapiens_hsa04115	0.55018337
82	Folate biosynthesis_Homo sapiens_hsa00790	0.53714954
83	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.51619805
84	Serotonergic synapse_Homo sapiens_hsa04726	0.49763556
85	Tyrosine metabolism_Homo sapiens_hsa00350	0.49382411
86	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.48445995
87	Pyrimidine metabolism_Homo sapiens_hsa00240	0.47498378
88	Olfactory transduction_Homo sapiens_hsa04740	0.43357921
89	PPAR signaling pathway_Homo sapiens_hsa03320	0.41663667
90	Phenylalanine metabolism_Homo sapiens_hsa00360	0.38973894
91	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.38864321
92	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.35860715
93	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.35544882
94	GABAergic synapse_Homo sapiens_hsa04727	0.34349206
95	Glycerolipid metabolism_Homo sapiens_hsa00561	0.33671397
96	Hippo signaling pathway_Homo sapiens_hsa04390	0.31858894
97	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.31794602
98	Pyruvate metabolism_Homo sapiens_hsa00620	0.30764524
99	Cocaine addiction_Homo sapiens_hsa05030	0.29749189
100	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.28659511

BRAFP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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