BRAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.89091061
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.89091061
3L-phenylalanine metabolic process (GO:0006558)6.62936450
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.62936450
5aromatic amino acid family catabolic process (GO:0009074)6.51619346
6tryptophan catabolic process (GO:0006569)6.18274724
7indole-containing compound catabolic process (GO:0042436)6.18274724
8indolalkylamine catabolic process (GO:0046218)6.18274724
9kynurenine metabolic process (GO:0070189)5.86271450
10urea metabolic process (GO:0019627)5.84271375
11urea cycle (GO:0000050)5.84271375
12tryptophan metabolic process (GO:0006568)5.76785075
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.69349889
14glyoxylate metabolic process (GO:0046487)5.59518143
15cysteine metabolic process (GO:0006534)5.50996923
16bile acid biosynthetic process (GO:0006699)5.48387966
17fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.43936275
18nitrogen cycle metabolic process (GO:0071941)5.43350047
19alpha-linolenic acid metabolic process (GO:0036109)5.30781266
20serine family amino acid catabolic process (GO:0009071)5.23746935
21sulfur amino acid catabolic process (GO:0000098)5.20613225
22complement activation, alternative pathway (GO:0006957)5.08725049
23regulation of protein activation cascade (GO:2000257)5.03501205
24protein carboxylation (GO:0018214)5.00530498
25peptidyl-glutamic acid carboxylation (GO:0017187)5.00530498
26amino-acid betaine metabolic process (GO:0006577)5.00336095
27high-density lipoprotein particle remodeling (GO:0034375)4.99913020
28negative regulation of fibrinolysis (GO:0051918)4.99804004
29homocysteine metabolic process (GO:0050667)4.97194606
30aromatic amino acid family metabolic process (GO:0009072)4.79509163
31lysine catabolic process (GO:0006554)4.75218884
32lysine metabolic process (GO:0006553)4.75218884
33regulation of complement activation (GO:0030449)4.74139871
34bile acid metabolic process (GO:0008206)4.69668319
35regulation of fibrinolysis (GO:0051917)4.69510332
36centriole replication (GO:0007099)4.66887938
37regulation of triglyceride catabolic process (GO:0010896)4.62493462
38tyrosine metabolic process (GO:0006570)4.47703191
39alpha-amino acid catabolic process (GO:1901606)4.44255671
40reverse cholesterol transport (GO:0043691)4.37256958
41negative regulation of sterol transport (GO:0032372)4.33049298
42negative regulation of cholesterol transport (GO:0032375)4.33049298
43regulation of T cell cytokine production (GO:0002724)4.28599634
44plasma lipoprotein particle remodeling (GO:0034369)4.25816814
45protein-lipid complex remodeling (GO:0034368)4.25816814
46macromolecular complex remodeling (GO:0034367)4.25816814
47indolalkylamine metabolic process (GO:0006586)4.25692898
48glycine metabolic process (GO:0006544)4.25246705
49phospholipid efflux (GO:0033700)4.24609339
50acylglycerol homeostasis (GO:0055090)4.23392515
51triglyceride homeostasis (GO:0070328)4.23392515
52serine family amino acid metabolic process (GO:0009069)4.21995369
53regulation of cholesterol esterification (GO:0010872)4.17049464
54coenzyme catabolic process (GO:0009109)4.12537483
55regulation of meiosis I (GO:0060631)4.12311651
56cellular amino acid catabolic process (GO:0009063)4.08908415
57bile acid and bile salt transport (GO:0015721)4.08188324
58cellular biogenic amine catabolic process (GO:0042402)4.06961458
59amine catabolic process (GO:0009310)4.06961458
60cellular modified amino acid catabolic process (GO:0042219)4.06611574
61translesion synthesis (GO:0019985)4.00544783
62positive regulation of mast cell activation involved in immune response (GO:0033008)3.96163456
63positive regulation of mast cell degranulation (GO:0043306)3.96163456
64regulation of mitotic spindle organization (GO:0060236)3.95943674
65cellular glucuronidation (GO:0052695)3.91639739
66plasma lipoprotein particle clearance (GO:0034381)3.91497004
67serine family amino acid biosynthetic process (GO:0009070)3.89522768
68benzene-containing compound metabolic process (GO:0042537)3.89203681
69imidazole-containing compound metabolic process (GO:0052803)3.88989659
70glutamate metabolic process (GO:0006536)3.88511719
71drug catabolic process (GO:0042737)3.86387468
72cellular biogenic amine biosynthetic process (GO:0042401)3.85267075
73cellular ketone body metabolic process (GO:0046950)3.84083654
74drug transmembrane transport (GO:0006855)3.82254436
75carnitine metabolic process (GO:0009437)3.80527456
76dicarboxylic acid biosynthetic process (GO:0043650)3.77648648
77urate metabolic process (GO:0046415)3.77121667
78cholesterol efflux (GO:0033344)3.71909553
79regulation of T cell tolerance induction (GO:0002664)3.71707581
80peroxisome fission (GO:0016559)3.70812241
81replication fork processing (GO:0031297)3.70429595
82nuclear pore organization (GO:0006999)3.70272643
83plasma lipoprotein particle assembly (GO:0034377)3.70012686
84positive regulation of triglyceride lipase activity (GO:0061365)3.68569047
85positive regulation of lipoprotein lipase activity (GO:0051006)3.68569047
86regulation of cholesterol homeostasis (GO:2000188)3.67284373
87positive regulation of lipid catabolic process (GO:0050996)3.66374517
88piRNA metabolic process (GO:0034587)3.65732839
89phospholipid homeostasis (GO:0055091)3.61234036
90regulation of bile acid biosynthetic process (GO:0070857)3.60510286
91carboxylic acid catabolic process (GO:0046395)3.59021295
92organic acid catabolic process (GO:0016054)3.59021295
93amine biosynthetic process (GO:0009309)3.58320499
94nuclear pore complex assembly (GO:0051292)3.56886763
95ethanol oxidation (GO:0006069)3.56884782
96NAD biosynthetic process (GO:0009435)3.55735260
97very-low-density lipoprotein particle assembly (GO:0034379)3.53824360
98nicotinamide nucleotide biosynthetic process (GO:0019359)3.52529077
99pyridine nucleotide biosynthetic process (GO:0019363)3.52529077
100complement activation, classical pathway (GO:0006958)3.51796629
101regulation of double-strand break repair via homologous recombination (GO:0010569)3.51359846
1022-oxoglutarate metabolic process (GO:0006103)3.50698927
103fibrinolysis (GO:0042730)3.50251103
104low-density lipoprotein particle remodeling (GO:0034374)3.49525415
105arginine metabolic process (GO:0006525)3.48833361
106acetyl-CoA metabolic process (GO:0006084)3.47258271
107exogenous drug catabolic process (GO:0042738)3.47224071
108cofactor catabolic process (GO:0051187)3.46125364
109cholesterol homeostasis (GO:0042632)3.46091234
110complement activation (GO:0006956)3.46008458
111aspartate family amino acid catabolic process (GO:0009068)3.45816735
112positive regulation of fatty acid beta-oxidation (GO:0032000)3.42962391
113cytolysis (GO:0019835)3.41844844
114sterol homeostasis (GO:0055092)3.41531263
115L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.40037289
116valine metabolic process (GO:0006573)3.38727929
117positive regulation of mast cell activation (GO:0033005)3.38687225
118protein-lipid complex assembly (GO:0065005)3.36697014
119resolution of meiotic recombination intermediates (GO:0000712)3.33918390
120centriole assembly (GO:0098534)3.33402025
121protein K11-linked deubiquitination (GO:0035871)3.27446702
122catecholamine biosynthetic process (GO:0042423)3.25071104
123catechol-containing compound biosynthetic process (GO:0009713)3.25071104
124genitalia morphogenesis (GO:0035112)3.21278588
125regulation of histone H3-K9 methylation (GO:0051570)3.14955939
126positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.14735525
127mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.14735525
128male meiosis (GO:0007140)3.12569497
129pyrimidine dimer repair (GO:0006290)3.12526430
130negative regulation of DNA recombination (GO:0045910)3.11960582
131negative regulation of translational initiation (GO:0045947)3.10678806
132cellular response to virus (GO:0098586)3.09691273
133mRNA modification (GO:0016556)3.09641451
134regulation of mast cell activation involved in immune response (GO:0033006)3.08663100
135regulation of tolerance induction (GO:0002643)3.06728548
136left/right axis specification (GO:0070986)3.06622250
137positive regulation of leukocyte degranulation (GO:0043302)3.04949873
138mitotic chromosome condensation (GO:0007076)3.04017727
139regulation of spindle organization (GO:0090224)3.01987078
140negative regulation of mast cell activation (GO:0033004)3.01788874
141pore complex assembly (GO:0046931)3.01787922
142postreplication repair (GO:0006301)2.97284267
143substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.94091386
144substrate-independent telencephalic tangential migration (GO:0021826)2.94091386
145RNA destabilization (GO:0050779)2.93855293
146male meiosis I (GO:0007141)2.93822895
147intra-S DNA damage checkpoint (GO:0031573)2.92834655
148DNA methylation involved in gamete generation (GO:0043046)2.89827604
149chromatin remodeling at centromere (GO:0031055)2.85107513
150DNA replication-dependent nucleosome assembly (GO:0006335)2.84698506
151DNA replication-dependent nucleosome organization (GO:0034723)2.84698506
152DNA replication checkpoint (GO:0000076)2.84185822
153regulation of RNA export from nucleus (GO:0046831)2.81833470
154positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.78654991
155S-adenosylmethionine metabolic process (GO:0046500)2.77751806
156negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.77348544
157synapsis (GO:0007129)2.77116060
158histone H2A acetylation (GO:0043968)2.75977498
159dosage compensation (GO:0007549)2.75223073
160protein targeting to lysosome (GO:0006622)2.74611089
161establishment of protein localization to vacuole (GO:0072666)2.74611089
162protein targeting to vacuole (GO:0006623)2.74611089
163somatic diversification of immune receptors via somatic mutation (GO:0002566)2.74016477
164somatic hypermutation of immunoglobulin genes (GO:0016446)2.74016477
165T cell apoptotic process (GO:0070231)2.71394359
166maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.66308337
167regulation of penile erection (GO:0060405)2.64191241
168neuron remodeling (GO:0016322)2.62718178
169regulation of centriole replication (GO:0046599)2.62351449
170telomere maintenance via semi-conservative replication (GO:0032201)2.61929072
171CENP-A containing nucleosome assembly (GO:0034080)2.61204575
172regulation of glucokinase activity (GO:0033131)2.61083661
173regulation of hexokinase activity (GO:1903299)2.61083661
174pyrimidine nucleotide catabolic process (GO:0006244)2.57808099
175metallo-sulfur cluster assembly (GO:0031163)2.57737673
176iron-sulfur cluster assembly (GO:0016226)2.57737673
177L-methionine salvage (GO:0071267)2.56709880
178L-methionine biosynthetic process (GO:0071265)2.56709880
179amino acid salvage (GO:0043102)2.56709880
180DNA packaging (GO:0006323)2.55679084
181regulation of retinoic acid receptor signaling pathway (GO:0048385)2.53685862
182microtubule nucleation (GO:0007020)2.53576149
183RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.52300004
184exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.51726145
185meiotic nuclear division (GO:0007126)2.51201958
186centrosome duplication (GO:0051298)2.50998719
187regulation of DNA recombination (GO:0000018)2.50938378
188mitochondrial DNA replication (GO:0006264)2.50046877
189histone mRNA catabolic process (GO:0071044)2.49997357
190regulation of mast cell activation (GO:0033003)2.49171772
191nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.48771021
192mitotic sister chromatid cohesion (GO:0007064)2.47720583
193definitive hemopoiesis (GO:0060216)2.47253411
194positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.44902515
195chromosome organization involved in meiosis (GO:0070192)2.44863399
196tRNA modification (GO:0006400)2.41855090
197sister chromatid cohesion (GO:0007062)2.41221789
198regulation of RIG-I signaling pathway (GO:0039535)2.41215059
199mismatch repair (GO:0006298)2.40964146

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.54328583
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.62386545
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.45650505
4EGR1_23403033_ChIP-Seq_LIVER_Mouse6.42592779
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.90829210
6* FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.83113449
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.20588282
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.64251421
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.61348812
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.42022049
11E2F7_22180533_ChIP-Seq_HELA_Human3.24140903
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.78511553
13* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.73363552
14IGF1R_20145208_ChIP-Seq_DFB_Human2.65301102
15ZNF274_21170338_ChIP-Seq_K562_Hela2.62072035
16VDR_23849224_ChIP-Seq_CD4+_Human2.46485808
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.36285738
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.35380045
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.30699328
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.16021409
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.15132427
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.14237866
23NOTCH1_21737748_ChIP-Seq_TLL_Human2.10150930
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05748491
25* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.05027691
26ELK1_19687146_ChIP-ChIP_HELA_Human2.04361981
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.03341254
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00479405
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.5119668
30IRF1_19129219_ChIP-ChIP_H3396_Human1.95702687
31FOXP3_21729870_ChIP-Seq_TREG_Human1.94285392
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.92241298
33TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.90641532
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.88473881
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.87627761
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.86922606
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.85320308
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.79183170
39DCP1A_22483619_ChIP-Seq_HELA_Human1.69659000
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67052359
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.65647549
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.63258199
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.57325974
44RXRA_24833708_ChIP-Seq_LIVER_Mouse1.56960157
45FOXA2_19822575_ChIP-Seq_HepG2_Human1.55709775
46GABP_19822575_ChIP-Seq_HepG2_Human1.55303777
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50117149
48GBX2_23144817_ChIP-Seq_PC3_Human1.49796040
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.48392192
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.47297106
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46187469
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.45051154
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44176689
54* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.43933042
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43510948
56HNF4A_19822575_ChIP-Seq_HepG2_Human1.43348953
57TFEB_21752829_ChIP-Seq_HELA_Human1.37937257
58KDM5A_27292631_Chip-Seq_BREAST_Human1.37088489
59IRF8_22096565_ChIP-ChIP_GC-B_Human1.37056485
60EWS_26573619_Chip-Seq_HEK293_Human1.36998441
61CBP_20019798_ChIP-Seq_JUKART_Human1.35988697
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35988697
63PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35613901
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32277341
65* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32184377
66E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.29315790
67PKCTHETA_26484144_Chip-Seq_BREAST_Human1.28077262
68SRF_21415370_ChIP-Seq_HL-1_Mouse1.26030352
69FUS_26573619_Chip-Seq_HEK293_Human1.23106802
70SPI1_23547873_ChIP-Seq_NB4_Human1.22829732
71TP53_22573176_ChIP-Seq_HFKS_Human1.21587633
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.21263329
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20920852
74MYB_26560356_Chip-Seq_TH2_Human1.20520606
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.20154475
76KAP1_22055183_ChIP-Seq_ESCs_Mouse1.19447503
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18914310
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18177156
79MYC_18940864_ChIP-ChIP_HL60_Human1.18066010
80CIITA_25753668_ChIP-Seq_RAJI_Human1.17464256
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16516214
82* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15462539
83PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13471080
84MYB_21317192_ChIP-Seq_ERMYB_Mouse1.12781859
85CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11998973
86Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11741698
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11050446
88HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09845362
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08542940
90HTT_18923047_ChIP-ChIP_STHdh_Human1.08105693
91ER_23166858_ChIP-Seq_MCF-7_Human1.07904707
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07169550
93SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06438110
94CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04820428
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.04370945
96RARA_24833708_ChIP-Seq_LIVER_Mouse1.03523139
97MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.03058922
98ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02288720
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01963138
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00417767
101ZNF263_19887448_ChIP-Seq_K562_Human1.00026817
102NMYC_18555785_Chip-Seq_ESCs_Mouse0.99042206
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98988525
104SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98634520
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98183308
106GATA3_26560356_Chip-Seq_TH2_Human0.98055527
107FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97550622
108GATA1_22025678_ChIP-Seq_K562_Human0.97193123
109CLOCK_20551151_ChIP-Seq_293T_Human0.96604082
110CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95572311
111STAT3_18555785_Chip-Seq_ESCs_Mouse0.94301361
112E2F1_18555785_Chip-Seq_ESCs_Mouse0.93086420
113PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92980022
114PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92966729
115GATA4_25053715_ChIP-Seq_YYC3_Human0.92461395
116NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91011350
117SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90889209
118P300_18555785_Chip-Seq_ESCs_Mouse0.90263490
119GATA3_27048872_Chip-Seq_THYMUS_Human0.89833302
120PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89729249
121MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89414655
122TAF15_26573619_Chip-Seq_HEK293_Human0.89330336
123RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89052102
124CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88577082
125EGR1_19374776_ChIP-ChIP_THP-1_Human0.88562728
126SOX2_27498859_Chip-Seq_STOMACH_Mouse0.87244017
127TTF2_22483619_ChIP-Seq_HELA_Human0.86991346
128P300_19829295_ChIP-Seq_ESCs_Human0.86936406
129TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81712891
130STAT1_17558387_ChIP-Seq_HELA_Human0.81496691
131CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80291038
132STAT3_1855785_ChIP-Seq_MESCs_Mouse0.78777640
133RAD21_21589869_ChIP-Seq_MESCs_Mouse0.78114204
134RARB_24833708_ChIP-Seq_LIVER_Mouse0.78081022
135FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77842040
136RARG_19884340_ChIP-ChIP_MEFs_Mouse0.77425542
137GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.75819406
138ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.75649029
139BRD4_27068464_Chip-Seq_AML-cells_Mouse0.75275488
140P53_21459846_ChIP-Seq_SAOS-2_Human0.75224593
141SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75197442
142AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74778196
143BCOR_27268052_Chip-Seq_Bcells_Human0.73750921
144ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.69557051
145TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.69192461
146NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.69109173
147CEBPB_22108803_ChIP-Seq_LS180_Human0.68878233
148ESR2_21235772_ChIP-Seq_MCF-7_Human0.67909731
149IRF8_27001747_Chip-Seq_BMDM_Mouse0.67643179
150EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.67575789
151* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.66897248
152PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.65533593
153FOXO3_23340844_ChIP-Seq_DLD1_Human0.65010993
154SPI1_26923725_Chip-Seq_HPCs_Mouse0.62824353
155LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.62255387
156SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.62241881
157ESET_19884257_ChIP-Seq_ESCs_Mouse0.62052247
158BCL6_27268052_Chip-Seq_Bcells_Human0.61720101
159GATA6_25053715_ChIP-Seq_YYC3_Human0.61102229
160* TET1_21451524_ChIP-Seq_MESCs_Mouse0.60929595
161NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.60921212
162MYC_19915707_ChIP-ChIP_AK7_Human0.60850981
163CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.60320983
164PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.60145975
165RAC3_21632823_ChIP-Seq_H3396_Human0.59833270
166PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.59683684
167OCT4_20526341_ChIP-Seq_ESCs_Human0.59592165
168FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.59355124
169EGR1_19032775_ChIP-ChIP_M12_Human0.59326152
170PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.58948799
171FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.58831063
172BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.58321073
173FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.57510446
174SPI1_20517297_ChIP-Seq_HL60_Human0.57086285
175ERG_20517297_ChIP-Seq_VCAP_Human0.56981729
176AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.56117632
177SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.56072003
178MYB_26560356_Chip-Seq_TH1_Human0.55827401
179NFE2_27457419_Chip-Seq_LIVER_Mouse0.55590562
180GATA3_21867929_ChIP-Seq_CD8_Mouse0.55313811
181GATA1_19941827_ChIP-Seq_MEL_Mouse0.54764604
182PHF8_20622854_ChIP-Seq_HELA_Human0.54735889
183CDX2_22108803_ChIP-Seq_LS180_Human0.54600093
184PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.54055220
185MYC_27129775_Chip-Seq_CORNEA_Mouse0.54054745
186PPAR_26484153_Chip-Seq_NCI-H1993_Human0.53986758
187CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.53759613
188GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.52603314
189SOX2_21211035_ChIP-Seq_LN229_Human0.52325301
190LXR_22292898_ChIP-Seq_THP-1_Human0.52296593
191TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.51891960
192E2F1_20622854_ChIP-Seq_HELA_Human0.51861671

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.86093525
2MP0005360_urolithiasis7.01019021
3MP0005085_abnormal_gallbladder_physiolo5.89808218
4MP0005365_abnormal_bile_salt5.82672108
5MP0008875_abnormal_xenobiotic_pharmacok4.59879917
6MP0003787_abnormal_imprinting4.33074852
7MP0008877_abnormal_DNA_methylation4.22990357
8MP0003252_abnormal_bile_duct3.94035214
9MP0008058_abnormal_DNA_repair3.60205116
10MP0004147_increased_porphyrin_level3.36833975
11MP0003806_abnormal_nucleotide_metabolis3.28242366
12MP0010329_abnormal_lipoprotein_level3.27912903
13MP0009840_abnormal_foam_cell3.03352267
14MP0003693_abnormal_embryo_hatching2.95333170
15MP0005083_abnormal_biliary_tract2.78844936
16MP0005332_abnormal_amino_acid2.74201098
17MP0010094_abnormal_chromosome_stability2.72772061
18MP0003195_calcinosis2.61652460
19MP0001727_abnormal_embryo_implantation2.57974337
20MP0005410_abnormal_fertilization2.47375349
21MP0001919_abnormal_reproductive_system2.42986511
22MP0003121_genomic_imprinting2.39145622
23MP0004019_abnormal_vitamin_homeostasis2.38831344
24MP0001666_abnormal_nutrient_absorption2.34474636
25MP0003191_abnormal_cellular_cholesterol2.34363559
26MP0002138_abnormal_hepatobiliary_system2.29306757
27MP0000609_abnormal_liver_physiology2.15822499
28MP0008057_abnormal_DNA_replication2.08915699
29MP0001873_stomach_inflammation2.04599167
30MP0001529_abnormal_vocalization2.02700838
31MP0003111_abnormal_nucleus_morphology1.98349959
32MP0005389_reproductive_system_phenotype1.97692287
33MP0002118_abnormal_lipid_homeostasis1.97480947
34MP0005075_abnormal_melanosome_morpholog1.97055865
35MP0003868_abnormal_feces_composition1.85995690
36MP0006292_abnormal_olfactory_placode1.85221302
37MP0005670_abnormal_white_adipose1.83296249
38MP0005451_abnormal_body_composition1.80461288
39MP0005319_abnormal_enzyme/_coenzyme1.77683743
40MP0003123_paternal_imprinting1.67409766
41MP0001764_abnormal_homeostasis1.63464690
42MP0002735_abnormal_chemical_nociception1.56540837
43MP0003646_muscle_fatigue1.53718433
44MP0003786_premature_aging1.53517559
45MP0000569_abnormal_digit_pigmentation1.52876846
46MP0005647_abnormal_sex_gland1.47887208
47MP0008995_early_reproductive_senescence1.44936018
48MP0005584_abnormal_enzyme/coenzyme_acti1.43132406
49MP0003705_abnormal_hypodermis_morpholog1.42017925
50MP0009643_abnormal_urine_homeostasis1.41779329
51MP0002653_abnormal_ependyma_morphology1.36928490
52MP0008260_abnormal_autophagy1.34179540
53MP0006276_abnormal_autonomic_nervous1.32064420
54MP0008789_abnormal_olfactory_epithelium1.31527888
55MP0009764_decreased_sensitivity_to1.29961665
56MP0003221_abnormal_cardiomyocyte_apopto1.28209699
57MP0003656_abnormal_erythrocyte_physiolo1.28125773
58MP0004808_abnormal_hematopoietic_stem1.22753207
59MP0005645_abnormal_hypothalamus_physiol1.22508911
60MP0000598_abnormal_liver_morphology1.20594717
61MP0003186_abnormal_redox_activity1.16485061
62MP0003077_abnormal_cell_cycle1.16088060
63MP0003303_peritoneal_inflammation1.15324203
64MP0010352_gastrointestinal_tract_polyps1.14529537
65MP0000015_abnormal_ear_pigmentation1.14029104
66MP0009697_abnormal_copulation1.11839738
67MP0002638_abnormal_pupillary_reflex1.09593503
68MP0002254_reproductive_system_inflammat1.08748069
69MP0002095_abnormal_skin_pigmentation1.05361144
70MP0002148_abnormal_hypersensitivity_rea1.05151125
71MP0002102_abnormal_ear_morphology1.02892572
72MP0005636_abnormal_mineral_homeostasis1.02237791
73MP0008469_abnormal_protein_level0.98694813
74MP0000631_abnormal_neuroendocrine_gland0.97544216
75MP0009763_increased_sensitivity_to0.96092364
76MP0005397_hematopoietic_system_phenotyp0.95963362
77MP0001545_abnormal_hematopoietic_system0.95963362
78MP0004142_abnormal_muscle_tone0.94950342
79MP0002722_abnormal_immune_system0.94453004
80MP0002398_abnormal_bone_marrow0.94297339
81MP0000604_amyloidosis0.93630076
82MP0003011_delayed_dark_adaptation0.90797299
83MP0000689_abnormal_spleen_morphology0.90272644
84MP0005464_abnormal_platelet_physiology0.89799357
85MP0001188_hyperpigmentation0.87659505
86MP0006072_abnormal_retinal_apoptosis0.87231259
87MP0005248_abnormal_Harderian_gland0.86205729
88MP0009642_abnormal_blood_homeostasis0.85953685
89MP0001119_abnormal_female_reproductive0.85660118
90MP0001929_abnormal_gametogenesis0.84114860
91MP0005666_abnormal_adipose_tissue0.82497583
92MP0005499_abnormal_olfactory_system0.82331883
93MP0005394_taste/olfaction_phenotype0.82331883
94MP0000703_abnormal_thymus_morphology0.81569736
95MP0002928_abnormal_bile_duct0.81557409
96MP0003698_abnormal_male_reproductive0.81393082
97MP0002234_abnormal_pharynx_morphology0.80417664
98MP0005253_abnormal_eye_physiology0.79420539
99MP0000627_abnormal_mammary_gland0.78961161
100MP0001756_abnormal_urination0.78102072
101MP0004130_abnormal_muscle_cell0.77964360
102MP0002796_impaired_skin_barrier0.77516728
103MP0004381_abnormal_hair_follicle0.77484573
104MP0001730_embryonic_growth_arrest0.76600184
105MP0002136_abnormal_kidney_physiology0.75975822
106MP0009765_abnormal_xenobiotic_induced0.74926828
107MP0002405_respiratory_system_inflammati0.74511644
108MP0009046_muscle_twitch0.74475432
109MP0005408_hypopigmentation0.74338447
110MP0000647_abnormal_sebaceous_gland0.74173699
111MP0005334_abnormal_fat_pad0.73882556
112MP0003436_decreased_susceptibility_to0.73488187
113MP0000716_abnormal_immune_system0.72551086
114MP0002971_abnormal_brown_adipose0.71720577
115MP0003936_abnormal_reproductive_system0.71639120
116MP0001502_abnormal_circadian_rhythm0.70712366
117MP0000613_abnormal_salivary_gland0.70370170
118MP0003763_abnormal_thymus_physiology0.70162488
119MP0006036_abnormal_mitochondrial_physio0.68745487
120MP0002429_abnormal_blood_cell0.68729054
121MP0003950_abnormal_plasma_membrane0.68386827
122MP0000372_irregular_coat_pigmentation0.68241088
123MP0003300_gastrointestinal_ulcer0.68216731
124MP0001661_extended_life_span0.67971718
125MP0002078_abnormal_glucose_homeostasis0.66486193
126MP0005171_absent_coat_pigmentation0.66473807
127MP0002019_abnormal_tumor_incidence0.66137122
128MP0005395_other_phenotype0.66089742
129MP0000579_abnormal_nail_morphology0.65091459
130MP0002876_abnormal_thyroid_physiology0.65053957
131MP0004957_abnormal_blastocyst_morpholog0.64937944
132MP0000358_abnormal_cell_content/0.64899940
133MP0008932_abnormal_embryonic_tissue0.63008449
134MP0005220_abnormal_exocrine_pancreas0.60526772
135MP0005535_abnormal_body_temperature0.59983490
136MP0004947_skin_inflammation0.58532245
137MP0002168_other_aberrant_phenotype0.58316475
138MP0005376_homeostasis/metabolism_phenot0.57818640
139MP0001853_heart_inflammation0.57486677
140MP0005084_abnormal_gallbladder_morpholo0.57379822
141MP0006035_abnormal_mitochondrial_morpho0.55121963
142MP0003718_maternal_effect0.54507594
143MP0001765_abnormal_ion_homeostasis0.53942080
144MP0002161_abnormal_fertility/fecundity0.53669598
145MP0001845_abnormal_inflammatory_respons0.51520660
146MP0002060_abnormal_skin_morphology0.50732385
147MP0010368_abnormal_lymphatic_system0.48396504
148MP0010234_abnormal_vibrissa_follicle0.47599582
149MP0008961_abnormal_basal_metabolism0.46842878
150MP0009672_abnormal_birth_weight0.46101706
151MP0003453_abnormal_keratinocyte_physiol0.46039913
152MP0009115_abnormal_fat_cell0.45078571
153MP0003329_amyloid_beta_deposits0.44786859
154MP0000427_abnormal_hair_cycle0.44172979
155MP0003699_abnormal_female_reproductive0.41439663
156MP0002210_abnormal_sex_determination0.41385511
157MP0000653_abnormal_sex_gland0.40757698
158MP0002132_abnormal_respiratory_system0.40754700
159MP0005448_abnormal_energy_balance0.40408960
160MP0004782_abnormal_surfactant_physiolog0.39354788
161MP0005266_abnormal_metabolism0.39267367
162MP0002970_abnormal_white_adipose0.39039833
163MP0008873_increased_physiological_sensi0.38874269
164MP0006082_CNS_inflammation0.38753973
165MP0000639_abnormal_adrenal_gland0.38719605
166MP0003953_abnormal_hormone_level0.38597899
167MP0001145_abnormal_male_reproductive0.38399146
168MP0002160_abnormal_reproductive_system0.38094243
169MP0005058_abnormal_lysosome_morphology0.37803033
170MP0002135_abnormal_kidney_morphology0.37790308
171MP0005166_decreased_susceptibility_to0.37385695

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.59433286
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.56553896
3Intrahepatic cholestasis (HP:0001406)6.55990618
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.21687495
5Xanthomatosis (HP:0000991)5.84928108
6Prolonged partial thromboplastin time (HP:0003645)5.58983660
7Hypobetalipoproteinemia (HP:0003563)5.37693630
8Complement deficiency (HP:0004431)5.13535970
9Hyperlipoproteinemia (HP:0010980)4.93242255
10Joint hemorrhage (HP:0005261)4.54941108
11Abnormality of glutamine family amino acid metabolism (HP:0010902)4.33669455
12Epidermoid cyst (HP:0200040)4.33090004
13Hyperammonemia (HP:0001987)4.27860470
14Hypolipoproteinemia (HP:0010981)4.27653832
15Abnormality of sulfur amino acid metabolism (HP:0004339)4.25217322
16Abnormality of the common coagulation pathway (HP:0010990)4.17245533
17Hyperinsulinemic hypoglycemia (HP:0000825)4.16903668
18Abnormality of aspartate family amino acid metabolism (HP:0010899)4.10094336
19Abnormality of pyrimidine metabolism (HP:0004353)4.08136612
20Hypoalphalipoproteinemia (HP:0003233)4.05255075
21Abnormality of methionine metabolism (HP:0010901)4.04729498
22Hyperglycinemia (HP:0002154)4.03655790
23Hyperglycinuria (HP:0003108)4.03654165
24Ketosis (HP:0001946)4.01245595
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.89458829
26Failure to thrive in infancy (HP:0001531)3.88513219
27Abnormality of complement system (HP:0005339)3.81194043
28Abnormality of serine family amino acid metabolism (HP:0010894)3.73316938
29Abnormality of glycine metabolism (HP:0010895)3.73316938
30Fat malabsorption (HP:0002630)3.72151152
31Hypercholesterolemia (HP:0003124)3.62325692
32Male infertility (HP:0003251)3.60146508
33Myocardial infarction (HP:0001658)3.47040717
34Abnormality of the intrinsic pathway (HP:0010989)3.39859367
35Abnormality of nucleobase metabolism (HP:0010932)3.32258760
36Gonadotropin excess (HP:0000837)3.26562461
37Abnormality of fatty-acid metabolism (HP:0004359)3.25055344
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.19855163
39Submucous cleft hard palate (HP:0000176)3.18545868
40Hypoglycemic coma (HP:0001325)3.17416770
41Conjugated hyperbilirubinemia (HP:0002908)3.03290344
42Gout (HP:0001997)3.02984400
43Vascular calcification (HP:0004934)2.94535233
44Abnormality of purine metabolism (HP:0004352)2.94319834
45Abnormality of serum amino acid levels (HP:0003112)2.91509837
46Hyperbilirubinemia (HP:0002904)2.90818796
47Spontaneous abortion (HP:0005268)2.81137011
48Hepatocellular carcinoma (HP:0001402)2.80817524
49Steatorrhea (HP:0002570)2.80019323
50Systemic lupus erythematosus (HP:0002725)2.74869381
51Cone-rod dystrophy (HP:0000548)2.73326059
52Premature ovarian failure (HP:0008209)2.72779207
53Chromosomal breakage induced by crosslinking agents (HP:0003221)2.70844270
54Papillary thyroid carcinoma (HP:0002895)2.67516215
55Chromsome breakage (HP:0040012)2.66544168
56Shoulder girdle muscle weakness (HP:0003547)2.65707281
57Abnormality of chromosome stability (HP:0003220)2.65603810
58Proximal tubulopathy (HP:0000114)2.64944677
59Mitral stenosis (HP:0001718)2.64414329
60Cardiovascular calcification (HP:0011915)2.62555570
61Delayed CNS myelination (HP:0002188)2.55287636
62Alveolar cell carcinoma (HP:0006519)2.52975431
63Ketoacidosis (HP:0001993)2.52684222
64Attenuation of retinal blood vessels (HP:0007843)2.49970163
65Metabolic acidosis (HP:0001942)2.49716991
66Hemorrhage of the eye (HP:0011885)2.44602357
67Recurrent gram-negative bacterial infections (HP:0005420)2.43610562
68Abnormality of midbrain morphology (HP:0002418)2.43269697
69Molar tooth sign on MRI (HP:0002419)2.43269697
70Cholecystitis (HP:0001082)2.42756392
71Abnormal gallbladder physiology (HP:0012438)2.42756392
72Acanthocytosis (HP:0001927)2.42610104
73Abnormality of the musculature of the pelvis (HP:0001469)2.42379911
74Abnormality of the hip-girdle musculature (HP:0001445)2.42379911
75Dicarboxylic aciduria (HP:0003215)2.41504316
76Abnormality of dicarboxylic acid metabolism (HP:0010995)2.41504316
77Neoplasm of the tracheobronchial system (HP:0100552)2.39579619
78Pelvic girdle muscle weakness (HP:0003749)2.39196090
79Ectopic kidney (HP:0000086)2.38641434
80Abnormality of the renal cortex (HP:0011035)2.38413409
81Neonatal onset (HP:0003623)2.34473365
82Hypochromic microcytic anemia (HP:0004840)2.34411016
83Exertional dyspnea (HP:0002875)2.33344924
84Autoimmune thrombocytopenia (HP:0001973)2.32238868
85Volvulus (HP:0002580)2.31670356
86Skin nodule (HP:0200036)2.31301426
87Microretrognathia (HP:0000308)2.30302466
88Colon cancer (HP:0003003)2.29860992
89Menstrual irregularities (HP:0000858)2.29727312
90Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.29520059
91Abnormal protein N-linked glycosylation (HP:0012347)2.29520059
92Abnormal protein glycosylation (HP:0012346)2.29520059
93Abnormal glycosylation (HP:0012345)2.29520059
94Pancreatitis (HP:0001733)2.28963465
95Albinism (HP:0001022)2.26973541
96Disinhibition (HP:0000734)2.25863620
97Thyroid carcinoma (HP:0002890)2.25652743
98Malnutrition (HP:0004395)2.25364416
99Microvesicular hepatic steatosis (HP:0001414)2.23868042
100Lethargy (HP:0001254)2.23567740
101Stomatitis (HP:0010280)2.22630920
102Upper motor neuron abnormality (HP:0002127)2.21371689
103Lissencephaly (HP:0001339)2.20751812
104Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.20606587
105Abnormality of proline metabolism (HP:0010907)2.20300534
106Hydroxyprolinuria (HP:0003080)2.20300534
107Glomerulonephritis (HP:0000099)2.20292054
108Increased purine levels (HP:0004368)2.20202245
109Hyperuricemia (HP:0002149)2.20202245
110Abnormality of DNA repair (HP:0003254)2.20138569
111Sensorimotor neuropathy (HP:0007141)2.19206297
112Gingival bleeding (HP:0000225)2.19034930
113Myelodysplasia (HP:0002863)2.18508415
114Amyotrophic lateral sclerosis (HP:0007354)2.17463764
115Hematochezia (HP:0002573)2.17128495
116Abnormality of the labia minora (HP:0012880)2.15915192
117Papilledema (HP:0001085)2.14816785
118Truncal obesity (HP:0001956)2.14528382
119Cholelithiasis (HP:0001081)2.13946934
120Abnormal gallbladder morphology (HP:0012437)2.13719071
121Abnormality of the lower motor neuron (HP:0002366)2.12552554
122Abnormal number of incisors (HP:0011064)2.11948410
123Irritability (HP:0000737)2.11429086
124Esophageal varix (HP:0002040)2.11186205
125Azoospermia (HP:0000027)2.10820980
126Menorrhagia (HP:0000132)2.08628172
127Abnormality of the pons (HP:0007361)2.04994623
128Thrombophlebitis (HP:0004418)2.04824508
129Hip dysplasia (HP:0001385)2.04232170
130Type I transferrin isoform profile (HP:0003642)2.03999330
131Hypergonadotropic hypogonadism (HP:0000815)2.02950950
132Orthostatic hypotension (HP:0001278)2.02790744
133Poikilocytosis (HP:0004447)2.02634576
134Neoplasm of the adrenal cortex (HP:0100641)2.01568827
135Progressive inability to walk (HP:0002505)2.01405261
136Abnormality of the renal collecting system (HP:0004742)2.00523994
137Heterotopia (HP:0002282)1.99136521
138Renal cortical cysts (HP:0000803)1.99101961
139Enlarged kidneys (HP:0000105)1.99073734
140Delayed puberty (HP:0000823)1.98692191
141Duplicated collecting system (HP:0000081)1.97696995
142Abnormality of macular pigmentation (HP:0008002)1.97622451
143Hypertriglyceridemia (HP:0002155)1.95952102
144Abnormality of B cell number (HP:0010975)1.95948715
145Bone marrow hypocellularity (HP:0005528)1.95349603
146Fatigue (HP:0012378)1.94770984
147Abnormal enzyme/coenzyme activity (HP:0012379)1.93415067
148Aplastic anemia (HP:0001915)1.92801099
149Late onset (HP:0003584)1.92474354
150Generalized aminoaciduria (HP:0002909)1.92248760
151Spastic diplegia (HP:0001264)1.89143073
152Elevated hepatic transaminases (HP:0002910)1.88833752
153Secondary amenorrhea (HP:0000869)1.87237773
154Abnormal spermatogenesis (HP:0008669)1.86967591
155Alkalosis (HP:0001948)1.86479659
156Impaired vibration sensation in the lower limbs (HP:0002166)1.86469428
157Resting tremor (HP:0002322)1.86252908
158Constricted visual fields (HP:0001133)1.85523155
159Absent/shortened dynein arms (HP:0200106)1.84848180
160Dynein arm defect of respiratory motile cilia (HP:0012255)1.84848180
161Chronic hepatic failure (HP:0100626)1.84601151
162Rickets (HP:0002748)1.83332508
163Tubulointerstitial nephritis (HP:0001970)1.82552010
164Spastic gait (HP:0002064)1.82437672
165Hypoglycemic seizures (HP:0002173)1.82144756
166Facial hemangioma (HP:0000329)1.81728473
167Poor eye contact (HP:0000817)1.81444166
168Cutaneous melanoma (HP:0012056)1.80924322
169Abnormality of the gallbladder (HP:0005264)1.80745582
170Nephritis (HP:0000123)1.80370543
171Rimmed vacuoles (HP:0003805)1.79871738
172Abnormal cartilage morphology (HP:0002763)1.79453827
173Neurodegeneration (HP:0002180)1.79393259
174Nasal polyposis (HP:0100582)1.79245613
175Oculomotor apraxia (HP:0000657)1.78746799
176Congenital stationary night blindness (HP:0007642)1.77782527
177Median cleft lip (HP:0000161)1.76621333
178Episodic fever (HP:0001954)1.75897015
179Impaired vibratory sensation (HP:0002495)1.74080760
180Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.73448059
181Urinary urgency (HP:0000012)1.73149598
182Hypoplasia of the pons (HP:0012110)1.70930663
183Deep palmar crease (HP:0006191)1.70361209
184Acute hepatic failure (HP:0006554)1.68992629
185Abnormality of the renal medulla (HP:0100957)1.68505312
186Pachygyria (HP:0001302)1.68302643
187Postnatal microcephaly (HP:0005484)1.67297207
188Granulocytopenia (HP:0001913)1.65433438
189Inappropriate behavior (HP:0000719)1.65198642
190Pancreatic cysts (HP:0001737)1.64599638
191Sloping forehead (HP:0000340)1.63919881
192Aplasia/Hypoplasia of the uvula (HP:0010293)1.63473284
193Paraplegia (HP:0010550)1.62509051
194Petechiae (HP:0000967)1.62097384
195Increased CSF protein (HP:0002922)1.61615038
196Atrophy/Degeneration involving motor neurons (HP:0007373)1.61522232
197Stomach cancer (HP:0012126)1.59656764
198Spastic paraplegia (HP:0001258)1.59331655
199Absent speech (HP:0001344)1.59020548

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK5.15130359
2TRIM285.02711754
3BCKDK4.38103554
4PDK33.63219633
5PDK43.63219633
6CDK93.52603271
7FGFR43.52031291
8PNCK3.40518912
9AKT33.40124044
10IRAK33.27711407
11LATS12.93676850
12ERN12.83031552
13SIK12.82468147
14CDC72.61306388
15PKN22.51367311
16STK38L2.34994672
17MAP3K42.30014678
18TRIB32.24158636
19PDK22.20887296
20TAOK32.17838885
21PINK12.10942875
22MAP2K72.07515726
23SRPK12.05680614
24TTK2.03090872
25INSRR1.87531991
26GRK11.82242182
27STK381.77707479
28TESK11.69662363
29FRK1.64947788
30ERBB41.61126944
31ERBB31.58414346
32IRAK11.54212253
33FLT31.51654264
34EPHA31.49183428
35MAP4K21.43824914
36LATS21.42926264
37EIF2AK31.41900910
38PLK41.41655796
39ZAK1.40973690
40WNK31.36023799
41BMPR21.35923735
42NEK91.35908996
43EPHB11.35696972
44CSNK1A1L1.32461258
45TYK21.32319506
46BCR1.31589826
47PIK3CG1.30863430
48JAK11.24718530
49IRAK21.23481503
50CSNK1G31.22639546
51MAPK111.22247266
52RPS6KA41.17659552
53MAP3K141.16074841
54CSNK1G11.15989842
55VRK11.15875060
56MAP2K41.14447049
57STK31.14148376
58MST1R1.12330488
59BRSK21.09470330
60SGK31.09376982
61FER1.09216081
62ATR1.05791030
63MAP4K11.05083973
64CDK191.04932769
65CSNK1G21.04389527
66TESK21.03382648
67PRKD31.01645797
68FGFR30.98428262
69EIF2AK10.98186943
70BRAF0.97922096
71PTK60.97741837
72MAP3K70.97735547
73ICK0.94093686
74JAK20.92566315
75MAPKAPK30.90992199
76PLK10.90962820
77ABL20.90529632
78PDK10.90074922
79MAP2K30.89590703
80IRAK40.87321675
81MAP3K30.84876303
82DYRK30.83626901
83PLK20.81465724
84MST40.80199776
85WEE10.80132089
86SGK20.79928864
87PRKCE0.79922612
88PRKAA20.78299005
89CAMK1D0.78116037
90WNK40.76333781
91PRKAA10.75321998
92ATM0.74750238
93TBK10.74571505
94CDK60.71251530
95PDPK10.70927601
96MATK0.68495772
97ZAP700.67948199
98JAK30.67400810
99GRK60.66537653
100GRK70.66441763
101PRKCZ0.65348698
102RIPK10.65264983
103CAMKK20.62072789
104BRD40.61395483
105PASK0.61140766
106CHEK10.60391197
107DYRK1B0.59356840
108EEF2K0.58679069
109MAPK40.58435885
110NEK20.55882290
111PLK30.54853130
112MTOR0.54095322
113RPS6KA50.53482366
114NLK0.52386693
115MAP3K100.51384509
116CSNK2A10.50706298
117MAP2K60.50539074
118CAMKK10.50476950
119IKBKE0.50439292
120MARK30.50110943
121PRKCI0.49799451
122TGFBR20.49218413
123FGFR20.48912113
124RET0.48730460
125MAP3K110.48444996
126TAOK10.48435559
127EPHA20.47378383
128MAPK70.47345212
129PTK2B0.46682004
130CSK0.46035163
131DYRK20.45535939
132CSNK1E0.45008148
133CDK40.44883348
134PRKD20.44503416
135CAMK1G0.42587948
136CHUK0.42502783
137MAP3K130.41569956
138DYRK1A0.41479112
139PIM10.41458911
140ERBB20.40040141
141PTK20.39746083
142STK240.37435362
143CSF1R0.37348140
144MAP3K10.36646953
145CDK70.35997188
146CHEK20.35770522
147TXK0.35101515
148SGK2230.34975751
149SGK4940.34975751
150NUAK10.34599217
151AURKA0.34434691
152CDK20.34163040
153ADRBK20.33954082
154STK100.33830407
155PKN10.33818687
156LYN0.33599394
157TAF10.32708680
158MAPK100.32578899
159PRKCG0.32568819
160MAP3K50.31494006
161STK110.31069498
162AURKB0.30772094
163CSNK2A20.29703722
164IKBKB0.29597480
165CCNB10.29474051
166PRKACG0.29430801
167FES0.27579229
168MAPK10.27448557

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.34369665
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.30524894
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.22758614
4Nitrogen metabolism_Homo sapiens_hsa009103.21295989
5Mismatch repair_Homo sapiens_hsa034302.97873197
6RNA degradation_Homo sapiens_hsa030182.94329706
7Fanconi anemia pathway_Homo sapiens_hsa034602.92727055
8Arginine biosynthesis_Homo sapiens_hsa002202.89036655
9Basal transcription factors_Homo sapiens_hsa030222.87182601
10DNA replication_Homo sapiens_hsa030302.78628219
11Fatty acid degradation_Homo sapiens_hsa000712.66095948
12Complement and coagulation cascades_Homo sapiens_hsa046102.61203267
13Tryptophan metabolism_Homo sapiens_hsa003802.59783696
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.52512096
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.45542804
16RNA transport_Homo sapiens_hsa030132.42690614
17Homologous recombination_Homo sapiens_hsa034402.42198435
18Nucleotide excision repair_Homo sapiens_hsa034202.38553824
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.36887135
20Pentose and glucuronate interconversions_Homo sapiens_hsa000402.29041379
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.28594051
22Spliceosome_Homo sapiens_hsa030402.19254121
23Non-homologous end-joining_Homo sapiens_hsa034502.18725142
24Propanoate metabolism_Homo sapiens_hsa006402.18302197
25Peroxisome_Homo sapiens_hsa041462.14350118
26PPAR signaling pathway_Homo sapiens_hsa033202.09527789
27RNA polymerase_Homo sapiens_hsa030201.99039420
28Butanoate metabolism_Homo sapiens_hsa006501.98733882
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.94567929
30Selenocompound metabolism_Homo sapiens_hsa004501.88370041
31Fatty acid metabolism_Homo sapiens_hsa012121.87218560
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.80080824
33Chemical carcinogenesis_Homo sapiens_hsa052041.79429932
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.79182790
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.76868918
36Staphylococcus aureus infection_Homo sapiens_hsa051501.75863924
37beta-Alanine metabolism_Homo sapiens_hsa004101.74749714
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.72685681
39Base excision repair_Homo sapiens_hsa034101.70811505
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.70748877
41Histidine metabolism_Homo sapiens_hsa003401.69775467
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.64356543
43Vitamin B6 metabolism_Homo sapiens_hsa007501.63019048
44Caffeine metabolism_Homo sapiens_hsa002321.61889888
45Pyruvate metabolism_Homo sapiens_hsa006201.59312682
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.57830068
47Retinol metabolism_Homo sapiens_hsa008301.57547978
48Thyroid cancer_Homo sapiens_hsa052161.57189357
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.56646629
50Cell cycle_Homo sapiens_hsa041101.55827150
51Phenylalanine metabolism_Homo sapiens_hsa003601.52989801
52mRNA surveillance pathway_Homo sapiens_hsa030151.52857734
53Bile secretion_Homo sapiens_hsa049761.48381122
54Legionellosis_Homo sapiens_hsa051341.45739992
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.42016585
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40908143
57Pyrimidine metabolism_Homo sapiens_hsa002401.39399190
58ABC transporters_Homo sapiens_hsa020101.39199925
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.38703681
60NOD-like receptor signaling pathway_Homo sapiens_hsa046211.35811129
61SNARE interactions in vesicular transport_Homo sapiens_hsa041301.34574583
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34038779
63Starch and sucrose metabolism_Homo sapiens_hsa005001.30383835
64Tyrosine metabolism_Homo sapiens_hsa003501.27559763
65Asthma_Homo sapiens_hsa053101.24969765
66Biosynthesis of amino acids_Homo sapiens_hsa012301.24623174
67p53 signaling pathway_Homo sapiens_hsa041151.22104957
68Fat digestion and absorption_Homo sapiens_hsa049751.21205530
69Carbon metabolism_Homo sapiens_hsa012001.18572124
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18077135
71Cyanoamino acid metabolism_Homo sapiens_hsa004601.17860416
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14828270
73Circadian rhythm_Homo sapiens_hsa047101.13569313
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13348814
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.13018331
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09865011
77Oocyte meiosis_Homo sapiens_hsa041141.08597521
78Jak-STAT signaling pathway_Homo sapiens_hsa046301.08271050
79Folate biosynthesis_Homo sapiens_hsa007901.05269938
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04456112
81Lysine degradation_Homo sapiens_hsa003101.00697106
82Vitamin digestion and absorption_Homo sapiens_hsa049770.99713394
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98282047
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.97983724
85Steroid biosynthesis_Homo sapiens_hsa001000.95979782
86Glycerolipid metabolism_Homo sapiens_hsa005610.95974318
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95737698
88Fatty acid biosynthesis_Homo sapiens_hsa000610.93946891
89Herpes simplex infection_Homo sapiens_hsa051680.93405583
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93004368
91Fatty acid elongation_Homo sapiens_hsa000620.89486024
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89265616
93Pentose phosphate pathway_Homo sapiens_hsa000300.89161893
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86095083
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85477345
96Sulfur metabolism_Homo sapiens_hsa009200.84152700
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82467562
98Hematopoietic cell lineage_Homo sapiens_hsa046400.81951099
99Arginine and proline metabolism_Homo sapiens_hsa003300.80696547
100Hepatitis B_Homo sapiens_hsa051610.80321413
101Measles_Homo sapiens_hsa051620.80164457
102Purine metabolism_Homo sapiens_hsa002300.79416082
103Shigellosis_Homo sapiens_hsa051310.74642019
104One carbon pool by folate_Homo sapiens_hsa006700.74204439
105Primary immunodeficiency_Homo sapiens_hsa053400.74087623
106Glutathione metabolism_Homo sapiens_hsa004800.73869900
107Viral carcinogenesis_Homo sapiens_hsa052030.73035895
108Sulfur relay system_Homo sapiens_hsa041220.72066430
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71927301
110Lysosome_Homo sapiens_hsa041420.70304722
111Maturity onset diabetes of the young_Homo sapiens_hsa049500.68789896
112mTOR signaling pathway_Homo sapiens_hsa041500.68390743
113Olfactory transduction_Homo sapiens_hsa047400.65706520
114TNF signaling pathway_Homo sapiens_hsa046680.61783714
115Phototransduction_Homo sapiens_hsa047440.61427146
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57986307
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53765184
118Prostate cancer_Homo sapiens_hsa052150.51669667
119Alcoholism_Homo sapiens_hsa050340.51004788
120Epstein-Barr virus infection_Homo sapiens_hsa051690.49616709
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.48393052
122Colorectal cancer_Homo sapiens_hsa052100.46517867
123Fructose and mannose metabolism_Homo sapiens_hsa000510.44965718
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44301409
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.43634832
126Insulin resistance_Homo sapiens_hsa049310.42340293
127Collecting duct acid secretion_Homo sapiens_hsa049660.42216469
128Glucagon signaling pathway_Homo sapiens_hsa049220.41348748
129Linoleic acid metabolism_Homo sapiens_hsa005910.41209379
130Metabolic pathways_Homo sapiens_hsa011000.40759643
131Taste transduction_Homo sapiens_hsa047420.37288841
132Sphingolipid metabolism_Homo sapiens_hsa006000.36759855
133Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36729236
134Influenza A_Homo sapiens_hsa051640.35954885
135Apoptosis_Homo sapiens_hsa042100.35389356
136Protein export_Homo sapiens_hsa030600.34079271
137Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32732324
138Pancreatic cancer_Homo sapiens_hsa052120.31400480
139Ether lipid metabolism_Homo sapiens_hsa005650.31028741
140Glycosaminoglycan degradation_Homo sapiens_hsa005310.26272223
141Prion diseases_Homo sapiens_hsa050200.22742491
142Galactose metabolism_Homo sapiens_hsa000520.20724421
143AMPK signaling pathway_Homo sapiens_hsa041520.16853584
144Carbohydrate digestion and absorption_Homo sapiens_hsa049730.13339923
145Insulin signaling pathway_Homo sapiens_hsa049100.04765129
146Central carbon metabolism in cancer_Homo sapiens_hsa052300.02284989
147Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.02069196
148Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.01583406
149Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1721156
150RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1541199
151Acute myeloid leukemia_Homo sapiens_hsa05221-0.1306082
152Renin-angiotensin system_Homo sapiens_hsa04614-0.1269302
153Dorso-ventral axis formation_Homo sapiens_hsa04320-0.1181226
154FoxO signaling pathway_Homo sapiens_hsa04068-0.1132394
155NF-kappa B signaling pathway_Homo sapiens_hsa04064-0.1122559
156Other glycan degradation_Homo sapiens_hsa00511-0.1115192
157Hepatitis C_Homo sapiens_hsa05160-0.1106627
158Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.1085041
159Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0850143
160Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0734909
161Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0695181
162Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.0694441
163Regulation of autophagy_Homo sapiens_hsa04140-0.0339387
164Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0236933

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