BRCA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.73174005
2nuclear pore complex assembly (GO:0051292)5.71955751
3protein localization to kinetochore (GO:0034501)5.53017141
4DNA unwinding involved in DNA replication (GO:0006268)5.51198065
5mitotic chromosome condensation (GO:0007076)4.85428716
6DNA replication-dependent nucleosome assembly (GO:0006335)4.75174844
7DNA replication-dependent nucleosome organization (GO:0034723)4.75174844
8DNA replication initiation (GO:0006270)4.73499272
9protein localization to chromosome, centromeric region (GO:0071459)4.65488374
10sister chromatid segregation (GO:0000819)4.64749411
11mitotic sister chromatid segregation (GO:0000070)4.62898932
12DNA strand elongation involved in DNA replication (GO:0006271)4.56539346
13kinetochore organization (GO:0051383)4.52496164
14mitotic metaphase plate congression (GO:0007080)4.40877048
15mitotic nuclear envelope disassembly (GO:0007077)4.40292818
16mitotic sister chromatid cohesion (GO:0007064)4.38466567
17pore complex assembly (GO:0046931)4.35288748
18DNA strand elongation (GO:0022616)4.32632444
19regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.18043094
20regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.16166244
21nuclear envelope disassembly (GO:0051081)4.13325353
22membrane disassembly (GO:0030397)4.13325353
23telomere maintenance via semi-conservative replication (GO:0032201)4.12811729
24chromatin remodeling at centromere (GO:0031055)4.11901352
25metaphase plate congression (GO:0051310)4.11053809
26DNA geometric change (GO:0032392)4.07361188
27DNA duplex unwinding (GO:0032508)4.06855158
28DNA replication checkpoint (GO:0000076)4.06155736
29replication fork processing (GO:0031297)4.05515315
30attachment of spindle microtubules to kinetochore (GO:0008608)4.01435624
31mitotic recombination (GO:0006312)4.01214200
32CENP-A containing nucleosome assembly (GO:0034080)4.00999561
33DNA ligation (GO:0006266)3.99944616
34folic acid-containing compound biosynthetic process (GO:0009396)3.93418082
35positive regulation of chromosome segregation (GO:0051984)3.93342975
36telomere maintenance via recombination (GO:0000722)3.87071999
37DNA replication-independent nucleosome assembly (GO:0006336)3.85875924
38DNA replication-independent nucleosome organization (GO:0034724)3.85875924
39* regulation of centriole replication (GO:0046599)3.85572097
40regulation of spindle organization (GO:0090224)3.81870644
41somatic hypermutation of immunoglobulin genes (GO:0016446)3.77436807
42somatic diversification of immune receptors via somatic mutation (GO:0002566)3.77436807
43pre-miRNA processing (GO:0031054)3.74664843
44meiotic chromosome segregation (GO:0045132)3.74562312
45IMP biosynthetic process (GO:0006188)3.73707257
46establishment of chromosome localization (GO:0051303)3.72565787
47regulation of sister chromatid cohesion (GO:0007063)3.71357735
48heterochromatin organization (GO:0070828)3.71229417
49kinetochore assembly (GO:0051382)3.69580577
50chromatin assembly or disassembly (GO:0006333)3.68479557
51positive regulation of mitotic sister chromatid separation (GO:1901970)3.65340669
52positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.65340669
53positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.65340669
54negative regulation of DNA-dependent DNA replication (GO:2000104)3.65016634
55regulation of helicase activity (GO:0051095)3.64075617
56microtubule depolymerization (GO:0007019)3.62697124
57histone exchange (GO:0043486)3.62051838
58chromatin assembly (GO:0031497)3.60384460
59non-recombinational repair (GO:0000726)3.59804218
60double-strand break repair via nonhomologous end joining (GO:0006303)3.59804218
61regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.57608128
62* regulation of histone H3-K9 methylation (GO:0051570)3.57487144
63regulation of chromosome segregation (GO:0051983)3.56552808
64regulation of mitotic spindle organization (GO:0060236)3.56052122
65protein localization to chromosome (GO:0034502)3.55289257
66centriole replication (GO:0007099)3.51904039
67spindle checkpoint (GO:0031577)3.46856179
68regulation of posttranscriptional gene silencing (GO:0060147)3.45830835
69regulation of gene silencing by miRNA (GO:0060964)3.45830835
70regulation of gene silencing by RNA (GO:0060966)3.45830835
71telomere maintenance via telomere lengthening (GO:0010833)3.45140242
72nucleotide-excision repair, DNA gap filling (GO:0006297)3.45014762
73DNA conformation change (GO:0071103)3.43491407
74regulation of mitotic metaphase/anaphase transition (GO:0030071)3.41986202
75regulation of DNA endoreduplication (GO:0032875)3.41342560
76mitotic G2/M transition checkpoint (GO:0044818)3.38253248
77negative regulation of chromosome segregation (GO:0051985)3.38013006
78DNA strand renaturation (GO:0000733)3.37417507
79spindle assembly checkpoint (GO:0071173)3.37145455
80chromosome condensation (GO:0030261)3.36534460
81DNA double-strand break processing (GO:0000729)3.36140939
82nucleobase biosynthetic process (GO:0046112)3.36087618
83regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.35621607
84translesion synthesis (GO:0019985)3.32743024
85* chromosome segregation (GO:0007059)3.30853445
86negative regulation of sister chromatid segregation (GO:0033046)3.30752170
87negative regulation of mitotic sister chromatid separation (GO:2000816)3.30752170
88negative regulation of mitotic sister chromatid segregation (GO:0033048)3.30752170
89negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.30752170
90DNA synthesis involved in DNA repair (GO:0000731)3.28599073
91IMP metabolic process (GO:0046040)3.28126812
92establishment of integrated proviral latency (GO:0075713)3.27989466
93mitotic cell cycle (GO:0000278)3.27244615
94regulation of sister chromatid segregation (GO:0033045)3.25663766
95regulation of mitotic sister chromatid separation (GO:0010965)3.25663766
96regulation of mitotic sister chromatid segregation (GO:0033047)3.25663766
97* regulation of centrosome cycle (GO:0046605)3.24346085
98sister chromatid cohesion (GO:0007062)3.24200880
99mitotic spindle checkpoint (GO:0071174)3.23995996
100mitotic spindle assembly checkpoint (GO:0007094)3.23813086
101* DNA replication (GO:0006260)3.23341350
102negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.22846048
103nuclear envelope organization (GO:0006998)3.21690862
104mismatch repair (GO:0006298)3.17750643
105ATP-dependent chromatin remodeling (GO:0043044)3.16919788
106* negative regulation of histone methylation (GO:0031061)3.15574813
107DNA topological change (GO:0006265)3.14886643
108synapsis (GO:0007129)3.14517907
109negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.11635633
110regulation of RNA export from nucleus (GO:0046831)3.10616676
111regulation of translational fidelity (GO:0006450)3.09276046
112DNA packaging (GO:0006323)3.06142424
113telomere maintenance (GO:0000723)3.03705294
114formation of translation preinitiation complex (GO:0001731)3.02806980
115ribosome assembly (GO:0042255)3.01752556
116maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.01457380
117telomere organization (GO:0032200)3.01114208
118regulation of double-strand break repair (GO:2000779)2.99597889

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.05065076
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.65602699
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.70513432
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.60433347
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.76372435
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.73984951
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.72644668
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.64825582
9AR_21909140_ChIP-Seq_LNCAP_Human2.59209656
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.54112437
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.48061571
12* EGR1_19374776_ChIP-ChIP_THP-1_Human2.46871362
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.29163225
14* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25911012
15MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.17585135
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.14520236
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.06190472
18* E2F7_22180533_ChIP-Seq_HELA_Human11.3347148
19SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.99643162
20EST1_17652178_ChIP-ChIP_JURKAT_Human1.88704584
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.87238780
22XRN2_22483619_ChIP-Seq_HELA_Human1.86716966
23MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83611152
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.80675706
25NANOG_18555785_ChIP-Seq_MESCs_Mouse1.76186233
26MYC_22102868_ChIP-Seq_BL_Human1.70880873
27* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68700544
28* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.66141564
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.61714436
30VDR_23849224_ChIP-Seq_CD4+_Human1.57918572
31POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.55791962
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50814094
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.50540727
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48116188
35FOXP3_21729870_ChIP-Seq_TREG_Human1.47501106
36* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.44528507
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44067755
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.44018921
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.41638095
40TTF2_22483619_ChIP-Seq_HELA_Human1.41630950
41KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.41486253
42KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.41486253
43KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.41486253
44ELK1_19687146_ChIP-ChIP_HELA_Human1.40294559
45* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.39633908
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38158628
47KDM5A_27292631_Chip-Seq_BREAST_Human1.38011751
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35565095
49DCP1A_22483619_ChIP-Seq_HELA_Human1.35118464
50CIITA_25753668_ChIP-Seq_RAJI_Human1.35088160
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34285161
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32291598
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32006131
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.31233230
55EWS_26573619_Chip-Seq_HEK293_Human1.27936331
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26395272
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24400260
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22700364
59GABP_19822575_ChIP-Seq_HepG2_Human1.22195052
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22033678
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19618328
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.18705986
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.18405757
64* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17372214
65* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17200843
66HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16525123
67TFEB_21752829_ChIP-Seq_HELA_Human1.14686894
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14499028
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14352502
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12417114
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.12019474
72* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12009280
73TCF3_18692474_ChIP-Seq_MEFs_Mouse1.10903129
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08378065
75* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08341897
76TCF3_18692474_ChIP-Seq_MESCs_Mouse1.06013660
77FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05478413
78FUS_26573619_Chip-Seq_HEK293_Human1.05133956
79* ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04909828
80* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03494007
81ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03222167
82* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02720215
83* NANOG_21062744_ChIP-ChIP_HESCs_Human1.02678457
84ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02019268
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01801744
86* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01172996
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99292962
88* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99039649
89ELF1_17652178_ChIP-ChIP_JURKAT_Human0.97731046
90IRF1_19129219_ChIP-ChIP_H3396_Human0.97648322
91NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.97238626
92NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96184489
93PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95583884
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92323881
95* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91431802
96ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90033847
97E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.89913329
98VDR_21846776_ChIP-Seq_THP-1_Human0.88702958
99SOX2_16153702_ChIP-ChIP_HESCs_Human0.87727472
100ZNF274_21170338_ChIP-Seq_K562_Hela0.84760089
101PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84118132
102CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.82610580
103HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.82052985
104NANOG_16153702_ChIP-ChIP_HESCs_Human0.81456808
105* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.81065423
106* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.80995588
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80787089
108SOX17_20123909_ChIP-Seq_XEN_Mouse0.79928886
109ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79795551
110* SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.78506280
111VDR_22108803_ChIP-Seq_LS180_Human0.78498966
112YY1_21170310_ChIP-Seq_MESCs_Mouse0.76875737
113MYC_18940864_ChIP-ChIP_HL60_Human0.75452305
114* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.75308770
115POU5F1_16153702_ChIP-ChIP_HESCs_Human0.72223158
116BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.70424379
117GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.65942878
118CHD1_26751641_Chip-Seq_LNCaP_Human0.63797545
119* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.59781764
120PKCTHETA_26484144_Chip-Seq_BREAST_Human0.57743008
121FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.57523649
122HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.57365683

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0010094_abnormal_chromosome_stability4.89072756
2MP0008057_abnormal_DNA_replication4.35358888
3* MP0003111_abnormal_nucleus_morphology4.29537192
4MP0003693_abnormal_embryo_hatching4.23848361
5MP0004957_abnormal_blastocyst_morpholog3.89935207
6* MP0003077_abnormal_cell_cycle3.86397709
7MP0008058_abnormal_DNA_repair2.98162644
8MP0010352_gastrointestinal_tract_polyps2.82166145
9MP0009697_abnormal_copulation2.52709011
10MP0008007_abnormal_cellular_replicative2.51374819
11MP0001730_embryonic_growth_arrest2.50009801
12MP0008932_abnormal_embryonic_tissue2.41377681
13MP0008877_abnormal_DNA_methylation2.37788471
14* MP0010307_abnormal_tumor_latency2.34966880
15MP0003123_paternal_imprinting2.33543029
16* MP0000350_abnormal_cell_proliferation2.33002666
17MP0006292_abnormal_olfactory_placode2.12933290
18MP0005076_abnormal_cell_differentiation2.02423060
19MP0003121_genomic_imprinting1.97000960
20MP0002396_abnormal_hematopoietic_system1.95061224
21* MP0001672_abnormal_embryogenesis/_devel1.93869184
22* MP0005380_embryogenesis_phenotype1.93869184
23MP0004197_abnormal_fetal_growth/weight/1.90182971
24* MP0001697_abnormal_embryo_size1.85361426
25* MP0002084_abnormal_developmental_patter1.84552706
26* MP0002085_abnormal_embryonic_tissue1.79578224
27MP0002009_preneoplasia1.78936890
28MP0003890_abnormal_embryonic-extraembry1.72062032
29* MP0002086_abnormal_extraembryonic_tissu1.71436829
30* MP0003984_embryonic_growth_retardation1.70666604
31* MP0002088_abnormal_embryonic_growth/wei1.67552989
32MP0004147_increased_porphyrin_level1.64372463
33MP0001293_anophthalmia1.63336553
34* MP0002080_prenatal_lethality1.63180974
35MP0003567_abnormal_fetal_cardiomyocyte1.57946027
36MP0004808_abnormal_hematopoietic_stem1.44004941
37MP0000490_abnormal_crypts_of1.43180950
38MP0000569_abnormal_digit_pigmentation1.36613734
39MP0000537_abnormal_urethra_morphology1.31516936
40* MP0000313_abnormal_cell_death1.31174406
41* MP0002019_abnormal_tumor_incidence1.29499621
42MP0010030_abnormal_orbit_morphology1.28182002
43MP0002877_abnormal_melanocyte_morpholog1.23059494
44MP0008995_early_reproductive_senescence1.22643611
45* MP0002210_abnormal_sex_determination1.21875221
46MP0002160_abnormal_reproductive_system1.19676669
47* MP0003786_premature_aging1.18336583
48MP0000372_irregular_coat_pigmentation1.17648563
49MP0000371_diluted_coat_color1.16133337
50MP0006072_abnormal_retinal_apoptosis1.12403413
51MP0009053_abnormal_anal_canal1.12124376
52MP0010234_abnormal_vibrissa_follicle1.10774759
53MP0003119_abnormal_digestive_system1.08397405
54* MP0001145_abnormal_male_reproductive1.07885460
55MP0009703_decreased_birth_body1.06732622
56MP0003787_abnormal_imprinting1.04281533
57MP0003941_abnormal_skin_development1.04198705
58* MP0003937_abnormal_limbs/digits/tail_de1.03449954
59MP0002092_abnormal_eye_morphology1.03099070
60MP0006035_abnormal_mitochondrial_morpho1.02688608
61MP0009672_abnormal_birth_weight1.00261058
62MP0003718_maternal_effect0.99952375
63MP0003136_yellow_coat_color0.99291899
64* MP0001929_abnormal_gametogenesis0.97293978
65MP0000733_abnormal_muscle_development0.96638337
66MP0002697_abnormal_eye_size0.96579492
67MP0001915_intracranial_hemorrhage0.96431949
68* MP0003698_abnormal_male_reproductive0.94255195
69MP0005171_absent_coat_pigmentation0.94124225
70MP0009278_abnormal_bone_marrow0.93651220
71MP0005397_hematopoietic_system_phenotyp0.93257928
72MP0001545_abnormal_hematopoietic_system0.93257928
73MP0004264_abnormal_extraembryonic_tissu0.92695480
74* MP0000653_abnormal_sex_gland0.90291728
75MP0001529_abnormal_vocalization0.90086692
76MP0005408_hypopigmentation0.89560647
77* MP0000703_abnormal_thymus_morphology0.89529426
78MP0003315_abnormal_perineum_morphology0.87808478
79MP0001661_extended_life_span0.86218873
80* MP0000358_abnormal_cell_content/0.86146608
81MP0006054_spinal_hemorrhage0.83046504
82MP0000432_abnormal_head_morphology0.82991369
83MP0005389_reproductive_system_phenotype0.82722663
84* MP0002111_abnormal_tail_morphology0.82208730
85MP0001346_abnormal_lacrimal_gland0.82165355
86MP0003943_abnormal_hepatobiliary_system0.82089101
87* MP0002075_abnormal_coat/hair_pigmentati0.80492864
88MP0001849_ear_inflammation0.79776893
89MP0001286_abnormal_eye_development0.79577085
90MP0000428_abnormal_craniofacial_morphol0.78971712
91* MP0005384_cellular_phenotype0.77020673
92* MP0005621_abnormal_cell_physiology0.77005852
93* MP0003699_abnormal_female_reproductive0.76103320
94MP0005083_abnormal_biliary_tract0.75191876
95MP0002234_abnormal_pharynx_morphology0.74849290
96* MP0005023_abnormal_wound_healing0.74540896
97* MP0002161_abnormal_fertility/fecundity0.74278025
98MP0003935_abnormal_craniofacial_develop0.73961038
99MP0004133_heterotaxia0.73868468
100MP0000631_abnormal_neuroendocrine_gland0.72474264
101MP0003806_abnormal_nucleotide_metabolis0.72190838
102* MP0002398_abnormal_bone_marrow0.71904829
103* MP0002925_abnormal_cardiovascular_devel0.71795993
104* MP0003566_abnormal_cell_adhesion0.71768445
105MP0002938_white_spotting0.70449033
106MP0003755_abnormal_palate_morphology0.69226742
107MP0001919_abnormal_reproductive_system0.68906068
108MP0000647_abnormal_sebaceous_gland0.68243686
109* MP0002722_abnormal_immune_system0.68033473
110MP0002653_abnormal_ependyma_morphology0.66822833
111MP0002751_abnormal_autonomic_nervous0.66552975
112* MP0001119_abnormal_female_reproductive0.65218714
113* MP0003861_abnormal_nervous_system0.65100093
114MP0010678_abnormal_skin_adnexa0.64817792
115MP0002233_abnormal_nose_morphology0.64774681
116MP0003115_abnormal_respiratory_system0.64613150
117MP0003283_abnormal_digestive_organ0.64478631
118MP0005623_abnormal_meninges_morphology0.63891708
119MP0000689_abnormal_spleen_morphology0.63831817
120MP0003385_abnormal_body_wall0.63585563
121MP0004185_abnormal_adipocyte_glucose0.63340012
122MP0002102_abnormal_ear_morphology0.63036897
123MP0005391_vision/eye_phenotype0.62997506
124MP0000383_abnormal_hair_follicle0.62145978
125MP0005257_abnormal_intraocular_pressure0.61592908
126MP0003950_abnormal_plasma_membrane0.61334676
127MP0005395_other_phenotype0.61058456
128MP0000566_synostosis0.60853584
129MP0003448_altered_tumor_morphology0.60828716
130MP0002163_abnormal_gland_morphology0.60577549
131* MP0003705_abnormal_hypodermis_morpholog0.59706618
132MP0000858_altered_metastatic_potential0.59603877
133MP0006036_abnormal_mitochondrial_physio0.57910907
134* MP0008770_decreased_survivor_rate0.57649365
135MP0009379_abnormal_foot_pigmentation0.56513766
136MP0000049_abnormal_middle_ear0.55910239
137* MP0002095_abnormal_skin_pigmentation0.54777478
138MP0008789_abnormal_olfactory_epithelium0.54742445

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.92690463
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.64038920
3Ependymoma (HP:0002888)4.36860359
4Medulloblastoma (HP:0002885)3.93943134
5Abnormality of chromosome stability (HP:0003220)3.74896701
6Birth length less than 3rd percentile (HP:0003561)3.61893331
7Rhabdomyosarcoma (HP:0002859)3.45748173
8Astrocytoma (HP:0009592)3.31408512
9Abnormality of the astrocytes (HP:0100707)3.31408512
10Colon cancer (HP:0003003)3.30982482
11Volvulus (HP:0002580)3.30089915
12Agnosia (HP:0010524)3.25757976
13Selective tooth agenesis (HP:0001592)3.24511338
14Meckel diverticulum (HP:0002245)3.16711416
15Abnormality of the labia minora (HP:0012880)3.15920806
16Aplasia/Hypoplasia of the uvula (HP:0010293)3.15202229
17Impulsivity (HP:0100710)3.10740773
18Reticulocytopenia (HP:0001896)3.07081402
19Abnormality of the ileum (HP:0001549)3.01159175
20Abnormality of the preputium (HP:0100587)2.99438809
21Increased nuchal translucency (HP:0010880)2.95688143
22Neoplasm of the oral cavity (HP:0100649)2.94596826
23Deviation of the thumb (HP:0009603)2.86236560
24Proximal placement of thumb (HP:0009623)2.86175464
25Glioma (HP:0009733)2.85188524
26Aplasia/Hypoplasia of the sacrum (HP:0008517)2.84242465
27Ectopic kidney (HP:0000086)2.83533011
28Patellar aplasia (HP:0006443)2.81584105
29Small intestinal stenosis (HP:0012848)2.81050427
30Duodenal stenosis (HP:0100867)2.81050427
31Neoplasm of striated muscle (HP:0009728)2.77526259
32Absent radius (HP:0003974)2.68574280
33Myelodysplasia (HP:0002863)2.65326416
34Basal cell carcinoma (HP:0002671)2.63003257
35Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.57601808
36Short 4th metacarpal (HP:0010044)2.57601808
37Aplasia/Hypoplasia of the patella (HP:0006498)2.57177224
38Cafe-au-lait spot (HP:0000957)2.53284126
39Breast hypoplasia (HP:0003187)2.51117379
40Abnormal number of incisors (HP:0011064)2.50538822
41Absent forearm bone (HP:0003953)2.49800228
42Aplasia involving forearm bones (HP:0009822)2.49800228
43Abnormality of the carotid arteries (HP:0005344)2.49392752
44Biliary tract neoplasm (HP:0100574)2.49234369
45Arteriovenous malformation (HP:0100026)2.43971653
46Sloping forehead (HP:0000340)2.42096921
47Cortical dysplasia (HP:0002539)2.40251277
48Absent thumb (HP:0009777)2.36269382
49Abnormality of the duodenum (HP:0002246)2.36245093
50Duplicated collecting system (HP:0000081)2.33847626
51Abnormality of cochlea (HP:0000375)2.31696921
52Prominent nose (HP:0000448)2.31294080
53Hypopigmentation of the fundus (HP:0007894)2.26973021
54Choanal atresia (HP:0000453)2.22481139
55Supernumerary spleens (HP:0009799)2.20563569
56Atresia of the external auditory canal (HP:0000413)2.20480663
57Nephroblastoma (Wilms tumor) (HP:0002667)2.20286492
58Neoplasm of the pancreas (HP:0002894)2.19320855
59Facial hemangioma (HP:0000329)2.19081422
60High pitched voice (HP:0001620)2.15722697
61Gastrointestinal carcinoma (HP:0002672)2.15490896
62Malignant gastrointestinal tract tumors (HP:0006749)2.15490896
63Amaurosis fugax (HP:0100576)2.14072967
64Missing ribs (HP:0000921)2.13866632
65Freckling (HP:0001480)2.10553032
66Abnormal lung lobation (HP:0002101)2.09951425
67Skull defect (HP:0001362)2.09702990
68Aplasia/Hypoplasia of the sternum (HP:0006714)2.07200922
69Abnormality of the renal collecting system (HP:0004742)2.07075216
70Short thumb (HP:0009778)2.06572147
71Embryonal renal neoplasm (HP:0011794)2.03820291
72Premature graying of hair (HP:0002216)2.01832065
73Sandal gap (HP:0001852)2.00892929
74Oral leukoplakia (HP:0002745)1.99794264
75Tracheoesophageal fistula (HP:0002575)1.99596864
7611 pairs of ribs (HP:0000878)1.99433355
77Abnormality of the fingertips (HP:0001211)1.99230742
78Bone marrow hypocellularity (HP:0005528)1.98038688
79Rib fusion (HP:0000902)1.96902929
80Embryonal neoplasm (HP:0002898)1.94510253
81Abnormality of cells of the erythroid lineage (HP:0012130)1.93239512
82Aplasia/hypoplasia of the humerus (HP:0006507)1.91858225
83Duplication of thumb phalanx (HP:0009942)1.91384658
84Squamous cell carcinoma (HP:0002860)1.90799982
85Clubbing of toes (HP:0100760)1.89996776
86Oligodactyly (hands) (HP:0001180)1.88277534
87Heterotopia (HP:0002282)1.88061954
88Cutaneous melanoma (HP:0012056)1.87907331
89Abnormality of the anterior horn cell (HP:0006802)1.87781105
90Degeneration of anterior horn cells (HP:0002398)1.87781105
91Neoplasm of the colon (HP:0100273)1.87483908
92Hypoplasia of the pons (HP:0012110)1.87044074
93Supernumerary ribs (HP:0005815)1.85771281
94Abnormality of abdominal situs (HP:0011620)1.85590183
95Abdominal situs inversus (HP:0003363)1.85590183
96Short humerus (HP:0005792)1.84108528
97Abnormality of DNA repair (HP:0003254)1.81357945
98Overlapping toe (HP:0001845)1.81090784
99Supernumerary bones of the axial skeleton (HP:0009144)1.80861339
100Abnormality of the pons (HP:0007361)1.80487222
101Small hand (HP:0200055)1.80293105
102Long eyelashes (HP:0000527)1.79966608
103Triphalangeal thumb (HP:0001199)1.78109359
104Aplasia/Hypoplasia of the earlobes (HP:0009906)1.77706739
105Abnormality of the 4th metacarpal (HP:0010012)1.76882561
106Abnormal number of erythroid precursors (HP:0012131)1.76075505
107Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.74848391
108Esophageal atresia (HP:0002032)1.74623678
109Deep philtrum (HP:0002002)1.73863520
110Horseshoe kidney (HP:0000085)1.72147495
111* Ovarian neoplasm (HP:0100615)1.71851698
112Pallor (HP:0000980)1.70640430
113Abnormality of chromosome segregation (HP:0002916)1.69934875
114Morphological abnormality of the inner ear (HP:0011390)1.69533730
115Oligohydramnios (HP:0001562)1.69442906
116Angiofibromas (HP:0010615)1.69319345
117Adenoma sebaceum (HP:0009720)1.69319345
118Astigmatism (HP:0000483)1.68857983
119Acute myeloid leukemia (HP:0004808)1.66508590
120Microvesicular hepatic steatosis (HP:0001414)1.65522678
121Poikiloderma (HP:0001029)1.63250766
122Pancytopenia (HP:0001876)1.62577852
123Capillary hemangiomas (HP:0005306)1.61864623
124Partial agenesis of the corpus callosum (HP:0001338)1.59768397
125Abnormality of homocysteine metabolism (HP:0010919)1.59328712
126Homocystinuria (HP:0002156)1.59328712
127Oligodactyly (HP:0012165)1.58068672
128Microglossia (HP:0000171)1.57279641
129High anterior hairline (HP:0009890)1.56917149
130Acute lymphatic leukemia (HP:0006721)1.56828081
131Abnormality of alanine metabolism (HP:0010916)1.55353914
132Hyperalaninemia (HP:0003348)1.55353914
133Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.55353914
134Abnormality of pyrimidine metabolism (HP:0004353)1.54572587
135Facial asymmetry (HP:0000324)1.53252466
136Ureteral duplication (HP:0000073)1.53132792
137Pendular nystagmus (HP:0012043)1.51553428
138Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.51529167
139Macrocytic anemia (HP:0001972)1.51014581

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.38524944
2WEE14.11461414
3CDK123.93730762
4NEK23.33825302
5TTK2.86865570
6BUB12.74548917
7NEK12.55472873
8SRPK12.26146846
9EEF2K2.16128294
10PLK12.06025083
11EIF2AK11.93892120
12RPS6KB21.88239411
13ACVR1B1.85357861
14* ATR1.84045777
15BRD41.83734269
16AURKB1.83497315
17SCYL21.81420076
18TLK11.79955975
19CDK71.78257590
20TAF11.75840780
21VRK21.71999418
22PLK41.71768131
23BRSK21.70709093
24PASK1.70510708
25TSSK61.66711675
26PKN21.65392838
27MKNK11.64513830
28EPHA21.57646738
29CHEK11.57632154
30PLK31.57406575
31STK41.57345839
32MAP3K81.56745648
33STK101.50699362
34* CHEK21.44500641
35MAP3K101.44058394
36BMPR1B1.38298464
37NUAK11.35556843
38CDK61.35243170
39ZAK1.34967955
40* ATM1.26426168
41LATS11.25085472
42DYRK31.24273186
43MKNK21.20144949
44* CDK41.18778684
45VRK11.15886736
46STK31.12155994
47BRSK11.11613765
48* CDK21.05716206
49MELK1.05109576
50RPS6KA41.04629416
51ALK0.98798513
52PIM10.95869608
53PAK40.95646084
54MST40.95496516
55TGFBR10.93849653
56FLT30.93346070
57WNK40.90849013
58EIF2AK30.89178717
59STK160.85721541
60MTOR0.85155196
61* CDK10.84999542
62CAMK1G0.80917926
63NME10.79180871
64* AURKA0.78558278
65TTN0.77798101
66TESK20.76938610
67PNCK0.75064436
68MET0.70375431
69CSNK1D0.67574985
70PLK20.67097921
71CCNB10.62998932
72BMX0.60523103
73CSNK2A20.58085646
74SMG10.57712596
75PDK20.57365825
76CDK90.56987844
77RPS6KA50.56982272
78LRRK20.54644404
79CDK30.52752025
80* PRKDC0.52631043
81MARK30.52327058
82NME20.52135879
83FGFR10.51468281
84FRK0.50925837
85WNK30.50914382
86MAPKAPK50.50405496
87CAMK1D0.48304828
88STK390.46245550
89AKT20.46225406
90MAPK140.45783895
91TRIM280.45604406
92CLK10.44997048
93PAK10.43948161
94CSNK1E0.43076991
95ICK0.42180470
96* CSNK2A10.40596645
97PAK20.39432711
98PRKCI0.37888668
99EIF2AK20.37342590
100STK38L0.36968542
101MST1R0.36270789
102INSRR0.34321838
103* AKT10.34287107
104MAPK10.32531790
105CDK80.31861637
106YES10.31404216
107MAP3K40.31386140
108* GSK3B0.30403884
109CSNK1G10.30071233
110LATS20.28415569
111PBK0.28168554
112MAPK110.28130810
113PDGFRA0.27519869
114PTK60.27380953
115BRAF0.26969133
116ERBB40.26242207
117MAP4K10.24644797
118TNIK0.23396216
119RPS6KB10.22518737
120NEK90.21693497
121RPS6KA10.21453784
122MAPKAPK30.21129822
123MAP4K20.20815566
124RAF10.20784279
125TRIB30.20366426
126MAP2K30.20108794
127ERBB30.20010741
128CHUK0.18396015

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.05344321
2Mismatch repair_Homo sapiens_hsa034304.64142118
3Cell cycle_Homo sapiens_hsa041103.32645457
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.30801722
5RNA transport_Homo sapiens_hsa030133.18280065
6Homologous recombination_Homo sapiens_hsa034403.10075451
7One carbon pool by folate_Homo sapiens_hsa006703.07627496
8Spliceosome_Homo sapiens_hsa030403.01780539
9Base excision repair_Homo sapiens_hsa034102.95020194
10Nucleotide excision repair_Homo sapiens_hsa034202.83167688
11Non-homologous end-joining_Homo sapiens_hsa034502.60941484
12* Fanconi anemia pathway_Homo sapiens_hsa034602.54635546
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.43195288
14Systemic lupus erythematosus_Homo sapiens_hsa053222.42318007
15mRNA surveillance pathway_Homo sapiens_hsa030152.11225682
16p53 signaling pathway_Homo sapiens_hsa041151.86865297
17RNA polymerase_Homo sapiens_hsa030201.83853130
18RNA degradation_Homo sapiens_hsa030181.81833890
19Ribosome_Homo sapiens_hsa030101.72572235
20Pyrimidine metabolism_Homo sapiens_hsa002401.66954473
21Basal transcription factors_Homo sapiens_hsa030221.64399034
22Viral carcinogenesis_Homo sapiens_hsa052031.52643114
23Protein export_Homo sapiens_hsa030601.39210728
24Proteasome_Homo sapiens_hsa030501.33629977
25* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.29593736
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.25404770
27Oocyte meiosis_Homo sapiens_hsa041141.24952557
28* MicroRNAs in cancer_Homo sapiens_hsa052061.21359543
29Epstein-Barr virus infection_Homo sapiens_hsa051691.12083657
30Alcoholism_Homo sapiens_hsa050341.10361314
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06337469
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06124020
33Small cell lung cancer_Homo sapiens_hsa052221.05337134
34Herpes simplex infection_Homo sapiens_hsa051681.03896573
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03876509
36HTLV-I infection_Homo sapiens_hsa051661.02269377
37Pyruvate metabolism_Homo sapiens_hsa006201.00351101
38Antigen processing and presentation_Homo sapiens_hsa046120.99188396
39Selenocompound metabolism_Homo sapiens_hsa004500.93450419
40Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93374707
41Folate biosynthesis_Homo sapiens_hsa007900.86117591
42Steroid biosynthesis_Homo sapiens_hsa001000.86054434
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85575205
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83781209
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83518776
46Adherens junction_Homo sapiens_hsa045200.79932623
47Colorectal cancer_Homo sapiens_hsa052100.79708106
48Propanoate metabolism_Homo sapiens_hsa006400.79111845
49Lysine degradation_Homo sapiens_hsa003100.78369710
50TGF-beta signaling pathway_Homo sapiens_hsa043500.78043976
51Basal cell carcinoma_Homo sapiens_hsa052170.76630881
52Purine metabolism_Homo sapiens_hsa002300.76538255
53Hippo signaling pathway_Homo sapiens_hsa043900.74309981
54Huntingtons disease_Homo sapiens_hsa050160.74172672
55Chronic myeloid leukemia_Homo sapiens_hsa052200.73935362
56Thyroid cancer_Homo sapiens_hsa052160.72378137
57Biosynthesis of amino acids_Homo sapiens_hsa012300.69862430
58Vitamin B6 metabolism_Homo sapiens_hsa007500.66697828
59mTOR signaling pathway_Homo sapiens_hsa041500.65743772
60Notch signaling pathway_Homo sapiens_hsa043300.61923449
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.61712979
62Parkinsons disease_Homo sapiens_hsa050120.60247107
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59475843
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58911580
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57437387
66Oxidative phosphorylation_Homo sapiens_hsa001900.55836374
67Apoptosis_Homo sapiens_hsa042100.55587459
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54964192
69Prostate cancer_Homo sapiens_hsa052150.54953898
70Hepatitis B_Homo sapiens_hsa051610.54762009
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54020466
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52740016
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52439813
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.50929050
75Bladder cancer_Homo sapiens_hsa052190.50714126
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.49802035
77Pathways in cancer_Homo sapiens_hsa052000.49259021
78Viral myocarditis_Homo sapiens_hsa054160.49107970
79Pentose phosphate pathway_Homo sapiens_hsa000300.48975132
80Non-small cell lung cancer_Homo sapiens_hsa052230.47884695
81Nitrogen metabolism_Homo sapiens_hsa009100.46295765
82Sulfur relay system_Homo sapiens_hsa041220.46064820
83Legionellosis_Homo sapiens_hsa051340.45965419
84Pancreatic cancer_Homo sapiens_hsa052120.45834175
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44846387
86Proteoglycans in cancer_Homo sapiens_hsa052050.44688085
87Hedgehog signaling pathway_Homo sapiens_hsa043400.41779540
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40711251
89Measles_Homo sapiens_hsa051620.40520068
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.40110214
91HIF-1 signaling pathway_Homo sapiens_hsa040660.39912220
92Melanoma_Homo sapiens_hsa052180.37576188
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36570232
94Metabolic pathways_Homo sapiens_hsa011000.35654865
95Endometrial cancer_Homo sapiens_hsa052130.34901177
96Tight junction_Homo sapiens_hsa045300.34829172
97Influenza A_Homo sapiens_hsa051640.34353135
98FoxO signaling pathway_Homo sapiens_hsa040680.32655461
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32466331
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31691882
101Glutathione metabolism_Homo sapiens_hsa004800.31457669
102Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31347615
103Butanoate metabolism_Homo sapiens_hsa006500.30726203
104Fatty acid metabolism_Homo sapiens_hsa012120.30657643
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.30142305
106Fatty acid elongation_Homo sapiens_hsa000620.29328046
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28779624
108Primary immunodeficiency_Homo sapiens_hsa053400.28671443
109Shigellosis_Homo sapiens_hsa051310.28476321
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27578168
111Acute myeloid leukemia_Homo sapiens_hsa052210.27556438
112Wnt signaling pathway_Homo sapiens_hsa043100.26882770
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26114750
114Olfactory transduction_Homo sapiens_hsa047400.25198989
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.23687271
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23596018
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23393010
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.22962254
119Asthma_Homo sapiens_hsa053100.20957513
120Hematopoietic cell lineage_Homo sapiens_hsa046400.20624559
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20614106
122* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19630470
123Focal adhesion_Homo sapiens_hsa045100.19315345
124Carbon metabolism_Homo sapiens_hsa012000.18732284
125N-Glycan biosynthesis_Homo sapiens_hsa005100.17380292
126B cell receptor signaling pathway_Homo sapiens_hsa046620.16747244
127Renin-angiotensin system_Homo sapiens_hsa046140.16230274
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16071879
129Alzheimers disease_Homo sapiens_hsa050100.15623293
130Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.14604870
131Renal cell carcinoma_Homo sapiens_hsa052110.13359457
132AMPK signaling pathway_Homo sapiens_hsa041520.12910125
133Glioma_Homo sapiens_hsa052140.12266964
134Phototransduction_Homo sapiens_hsa047440.11846319
135Fatty acid biosynthesis_Homo sapiens_hsa000610.10767648
136Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.08052746
137Maturity onset diabetes of the young_Homo sapiens_hsa049500.03963507

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