BRCC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.15664073
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.01559224
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.85049694
4ATP synthesis coupled proton transport (GO:0015986)4.85049694
5protein K6-linked ubiquitination (GO:0085020)4.36590130
6protein complex biogenesis (GO:0070271)4.36224002
7proteasome assembly (GO:0043248)4.32646394
8protein neddylation (GO:0045116)4.31257788
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.31075569
10mitochondrial respiratory chain complex I assembly (GO:0032981)4.31075569
11NADH dehydrogenase complex assembly (GO:0010257)4.31075569
12respiratory electron transport chain (GO:0022904)4.17061580
13respiratory chain complex IV assembly (GO:0008535)4.16459955
14electron transport chain (GO:0022900)4.07424279
15termination of RNA polymerase III transcription (GO:0006386)4.06117438
16transcription elongation from RNA polymerase III promoter (GO:0006385)4.06117438
17regulation of mitochondrial translation (GO:0070129)3.86936552
18mitochondrial respiratory chain complex assembly (GO:0033108)3.85305274
19cytochrome complex assembly (GO:0017004)3.75197835
20DNA deamination (GO:0045006)3.72400066
21dopamine transport (GO:0015872)3.71317072
22DNA strand elongation involved in DNA replication (GO:0006271)3.56786017
23DNA replication checkpoint (GO:0000076)3.55603199
24regulation of mitotic spindle checkpoint (GO:1903504)3.51560327
25regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.51560327
26positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.50775713
27replication fork processing (GO:0031297)3.49509080
28protein heterotetramerization (GO:0051290)3.49011406
29ribosome assembly (GO:0042255)3.47559961
30histone exchange (GO:0043486)3.46854133
31establishment of integrated proviral latency (GO:0075713)3.45972529
32DNA double-strand break processing (GO:0000729)3.44796978
33mannosylation (GO:0097502)3.44776388
34GTP biosynthetic process (GO:0006183)3.44541481
35DNA strand elongation (GO:0022616)3.42442481
36deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.40799096
37RNA capping (GO:0036260)3.38924167
387-methylguanosine RNA capping (GO:0009452)3.38924167
39positive regulation of ligase activity (GO:0051351)3.37405116
40water-soluble vitamin biosynthetic process (GO:0042364)3.36287028
41DNA catabolic process, exonucleolytic (GO:0000738)3.35873674
427-methylguanosine mRNA capping (GO:0006370)3.35385500
43chaperone-mediated protein transport (GO:0072321)3.32151031
44non-recombinational repair (GO:0000726)3.30562758
45double-strand break repair via nonhomologous end joining (GO:0006303)3.30562758
46CENP-A containing nucleosome assembly (GO:0034080)3.30469130
47regulation of DNA endoreduplication (GO:0032875)3.26768450
48establishment of viral latency (GO:0019043)3.25279851
49DNA ligation (GO:0006266)3.24987994
50L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.24046353
51deoxyribonucleotide biosynthetic process (GO:0009263)3.24007162
52negative regulation of DNA-dependent DNA replication (GO:2000104)3.20364963
53regulation of cellular amino acid metabolic process (GO:0006521)3.18994564
54nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.18065556
55signal peptide processing (GO:0006465)3.17403241
56negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.17382787
572-deoxyribonucleotide biosynthetic process (GO:0009265)3.16632178
58deoxyribose phosphate biosynthetic process (GO:0046385)3.16632178
59DNA replication-independent nucleosome organization (GO:0034724)3.15712878
60DNA replication-independent nucleosome assembly (GO:0006336)3.15712878
61nucleotide-excision repair, DNA gap filling (GO:0006297)3.14259309
62regulation of ubiquitin-protein transferase activity (GO:0051438)3.12510608
63GPI anchor biosynthetic process (GO:0006506)3.10767262
64exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.09856927
65postreplication repair (GO:0006301)3.06765972
66purine nucleobase biosynthetic process (GO:0009113)3.06696072
67DNA replication-dependent nucleosome assembly (GO:0006335)3.04463767
68DNA replication-dependent nucleosome organization (GO:0034723)3.04463767
69protein localization to kinetochore (GO:0034501)3.03582598
70nucleobase biosynthetic process (GO:0046112)3.03291760
71DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.03033306
72regulation of ligase activity (GO:0051340)3.02927441
73cullin deneddylation (GO:0010388)3.02664195
74DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.02315292
75guanosine-containing compound biosynthetic process (GO:1901070)3.02173673
76histone mRNA metabolic process (GO:0008334)3.01956319
77antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.01764056
78transcription elongation from RNA polymerase I promoter (GO:0006362)3.01396037
79axon ensheathment in central nervous system (GO:0032291)3.01266211
80central nervous system myelination (GO:0022010)3.01266211
81chromatin remodeling at centromere (GO:0031055)2.99958671
82telomere maintenance via semi-conservative replication (GO:0032201)2.98825322
83signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.98766097
84signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.98766097
85signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.98766097
86branched-chain amino acid catabolic process (GO:0009083)2.97273424
87intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.97265841
88signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.97265841
89rRNA modification (GO:0000154)2.96702777
90cell cycle G1/S phase transition (GO:0044843)2.95050280
91G1/S transition of mitotic cell cycle (GO:0000082)2.95050280
92deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.94969673
93ribosomal small subunit assembly (GO:0000028)2.94791578
94RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.94011730
95tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.94011730
96protein-cofactor linkage (GO:0018065)2.92807385
97positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.91617172
98deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.91323453
99DNA damage response, detection of DNA damage (GO:0042769)2.88067249
100maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.86503811
101negative regulation of ligase activity (GO:0051352)2.86020951
102negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.86020951
103GPI anchor metabolic process (GO:0006505)2.85241290
104kinetochore organization (GO:0051383)2.83576127
105telomere maintenance via recombination (GO:0000722)2.82661603
106signal transduction involved in DNA integrity checkpoint (GO:0072401)2.82617215
107signal transduction involved in DNA damage checkpoint (GO:0072422)2.82617215
108regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.81831064
109kinetochore assembly (GO:0051382)2.81100351
110ribosomal small subunit biogenesis (GO:0042274)2.80657841
111antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.80476594
112signal transduction involved in cell cycle checkpoint (GO:0072395)2.80185136
113mitotic sister chromatid segregation (GO:0000070)2.79750247
114protein deneddylation (GO:0000338)2.79277951
115preassembly of GPI anchor in ER membrane (GO:0016254)2.79226662
116negative regulation of protein ubiquitination (GO:0031397)2.77680017
117iron-sulfur cluster assembly (GO:0016226)2.76829626
118metallo-sulfur cluster assembly (GO:0031163)2.76829626
119pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.76800073
120establishment of protein localization to mitochondrial membrane (GO:0090151)2.75337004
121positive regulation of cell cycle arrest (GO:0071158)2.74772252
122UTP biosynthetic process (GO:0006228)2.74562345
123protein K11-linked ubiquitination (GO:0070979)2.74134804
124rRNA methylation (GO:0031167)2.73288072
125* response to X-ray (GO:0010165)2.73155000
126mitotic metaphase plate congression (GO:0007080)2.72944081
127spliceosomal snRNP assembly (GO:0000387)2.72640812
128attachment of spindle microtubules to kinetochore (GO:0008608)2.71997184
129somatic diversification of immune receptors via somatic mutation (GO:0002566)2.71511468
130somatic hypermutation of immunoglobulin genes (GO:0016446)2.71511468
131termination of RNA polymerase I transcription (GO:0006363)2.70778520
132protein targeting to mitochondrion (GO:0006626)2.70512092
133transcription-coupled nucleotide-excision repair (GO:0006283)2.70463678
134anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.69824571
135CTP metabolic process (GO:0046036)2.65265059
136CTP biosynthetic process (GO:0006241)2.65265059
137tRNA processing (GO:0008033)2.64838885
138pseudouridine synthesis (GO:0001522)2.62760947
139regulation of cellular amine metabolic process (GO:0033238)2.62671512
140pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.60977410
141aerobic respiration (GO:0009060)2.59055554
142maturation of 5.8S rRNA (GO:0000460)2.56977726
143establishment of protein localization to mitochondrion (GO:0072655)2.55257988
144mitotic recombination (GO:0006312)2.54738109
145positive regulation of protein homodimerization activity (GO:0090073)2.54583283
146hydrogen ion transmembrane transport (GO:1902600)2.54030942
147transcription from RNA polymerase I promoter (GO:0006360)2.53376763

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.65625817
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.59168401
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.41877537
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.39400501
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.34266563
6E2F7_22180533_ChIP-Seq_HELA_Human3.07201995
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.01764659
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.01109561
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.87955409
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.79954403
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.64117180
12TAF15_26573619_Chip-Seq_HEK293_Human2.59245135
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.57334584
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.55241740
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.45872830
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.38328931
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.28956194
18ELK1_19687146_ChIP-ChIP_HELA_Human2.24613689
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.21198033
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.18561797
21ZNF274_21170338_ChIP-Seq_K562_Hela2.14574568
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.13445156
23MYC_18555785_ChIP-Seq_MESCs_Mouse2.07280196
24VDR_23849224_ChIP-Seq_CD4+_Human2.06111254
25GBX2_23144817_ChIP-Seq_PC3_Human2.05700728
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.03959812
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98418342
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95622324
29E2F4_17652178_ChIP-ChIP_JURKAT_Human1.95536530
30* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.94414124
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.93400019
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.87861635
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.85764566
34FUS_26573619_Chip-Seq_HEK293_Human1.85169085
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83856497
36FOXP3_21729870_ChIP-Seq_TREG_Human1.78465717
37VDR_22108803_ChIP-Seq_LS180_Human1.76672717
38AR_21909140_ChIP-Seq_LNCAP_Human1.75739753
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72324243
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72138283
41IRF1_19129219_ChIP-ChIP_H3396_Human1.70209101
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69732090
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68153023
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.66670424
45MYC_18358816_ChIP-ChIP_MESCs_Mouse1.65425831
46EWS_26573619_Chip-Seq_HEK293_Human1.60921541
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56231313
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.55410948
49DCP1A_22483619_ChIP-Seq_HELA_Human1.54485841
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46081050
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.45201443
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37316720
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.35133502
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34793877
55P300_19829295_ChIP-Seq_ESCs_Human1.34567556
56TTF2_22483619_ChIP-Seq_HELA_Human1.31857699
57IGF1R_20145208_ChIP-Seq_DFB_Human1.31750172
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28841080
59ER_23166858_ChIP-Seq_MCF-7_Human1.28559325
60* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28556685
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.28545234
62MYC_18940864_ChIP-ChIP_HL60_Human1.28449887
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25903779
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25364843
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24872444
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.24360505
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24250868
68SUZ12_18555785_Chip-Seq_ESCs_Mouse1.23401993
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22434688
70STAT3_18555785_Chip-Seq_ESCs_Mouse1.19738178
71FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.19435151
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19259725
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18652810
74P53_22387025_ChIP-Seq_ESCs_Mouse1.16859904
75* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15398517
76EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15084435
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.14829778
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.14302511
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.13763629
80P300_18555785_Chip-Seq_ESCs_Mouse1.13385253
81IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.13225317
82FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12600567
83EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.11030139
84RUNX1_27457419_Chip-Seq_LIVER_Mouse1.10983573
85CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10480092
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.09960393
87NMYC_18555785_Chip-Seq_ESCs_Mouse1.09869674
88POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09697849
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09219688
90FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08645421
91MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08504715
92E2F1_18555785_Chip-Seq_ESCs_Mouse1.07016277
93EZH2_22144423_ChIP-Seq_EOC_Human1.06760075
94GABP_19822575_ChIP-Seq_HepG2_Human1.06000078
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05459895
96TAL1_26923725_Chip-Seq_HPCs_Mouse1.05168899
97KDM5A_27292631_Chip-Seq_BREAST_Human1.04800236
98* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04387988
99SOX2_18555785_Chip-Seq_ESCs_Mouse1.04157931
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03478411
101CMYC_18555785_Chip-Seq_ESCs_Mouse1.02078495
102MYC_19079543_ChIP-ChIP_MESCs_Mouse1.00650525
103NANOG_16153702_ChIP-ChIP_HESCs_Human0.99629386
104ELK1_22589737_ChIP-Seq_MCF10A_Human0.99370502
105XRN2_22483619_ChIP-Seq_HELA_Human0.98975265
106SMAD1_18555785_Chip-Seq_ESCs_Mouse0.98619183
107OCT4_18555785_Chip-Seq_ESCs_Mouse0.98200979
108HTT_18923047_ChIP-ChIP_STHdh_Human0.97929422
109ZFX_18555785_Chip-Seq_ESCs_Mouse0.97552263
110EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97023012
111ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96941578
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95793289
113CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95729692
114KLF4_18555785_Chip-Seq_ESCs_Mouse0.95468185
115NELFA_20434984_ChIP-Seq_ESCs_Mouse0.94811976
116GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94399629
117IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93442019
118CBP_20019798_ChIP-Seq_JUKART_Human0.93442019
119TP53_22573176_ChIP-Seq_HFKS_Human0.92209510
120RNF2_27304074_Chip-Seq_NSC_Mouse0.91440676
121CBX2_27304074_Chip-Seq_ESCs_Mouse0.90079316
122POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.89631020
123E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89153962
124SOX17_20123909_ChIP-Seq_XEN_Mouse0.88197189
125AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87451926
126CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86835750
127ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86071921
128GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.85708833
129SOX2_19829295_ChIP-Seq_ESCs_Human0.84782643
130NANOG_19829295_ChIP-Seq_ESCs_Human0.84782643
131MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83842829
132ELF5_23300383_ChIP-Seq_T47D_Human0.82360803
133CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81999320

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.16260464
2MP0001986_abnormal_taste_sensitivity3.15637169
3MP0001529_abnormal_vocalization3.04787862
4MP0006292_abnormal_olfactory_placode2.92728438
5MP0003806_abnormal_nucleotide_metabolis2.85022738
6MP0001905_abnormal_dopamine_level2.76783389
7MP0005379_endocrine/exocrine_gland_phen2.37639339
8MP0001188_hyperpigmentation2.34921383
9MP0009379_abnormal_foot_pigmentation2.30283367
10MP0008007_abnormal_cellular_replicative2.20669077
11MP0002735_abnormal_chemical_nociception2.14997994
12MP0003787_abnormal_imprinting2.14861047
13MP0009697_abnormal_copulation2.14693399
14MP0008057_abnormal_DNA_replication2.13624348
15MP0006276_abnormal_autonomic_nervous2.09902045
16MP0005423_abnormal_somatic_nervous1.96490236
17MP0008058_abnormal_DNA_repair1.95321503
18MP0010094_abnormal_chromosome_stability1.93274628
19MP0003136_yellow_coat_color1.92244262
20MP0002638_abnormal_pupillary_reflex1.86488975
21MP0002876_abnormal_thyroid_physiology1.84560461
22MP0003693_abnormal_embryo_hatching1.83635531
23MP0005171_absent_coat_pigmentation1.83627622
24MP0000372_irregular_coat_pigmentation1.79423379
25MP0005409_darkened_coat_color1.77327649
26MP0002163_abnormal_gland_morphology1.74051970
27MP0002272_abnormal_nervous_system1.72882099
28MP0002736_abnormal_nociception_after1.69889687
29MP0004142_abnormal_muscle_tone1.68513722
30MP0004147_increased_porphyrin_level1.65930872
31MP0008877_abnormal_DNA_methylation1.63060232
32MP0009046_muscle_twitch1.62590631
33MP0001968_abnormal_touch/_nociception1.58173743
34MP0008789_abnormal_olfactory_epithelium1.56684375
35MP0005645_abnormal_hypothalamus_physiol1.56546250
36MP0000566_synostosis1.55322757
37MP0002734_abnormal_mechanical_nocicepti1.49047164
38MP0004381_abnormal_hair_follicle1.48824221
39MP0003195_calcinosis1.48405246
40MP0009745_abnormal_behavioral_response1.46523374
41MP0000569_abnormal_digit_pigmentation1.45821942
42MP0003122_maternal_imprinting1.45568334
43MP0002102_abnormal_ear_morphology1.42395754
44MP0003121_genomic_imprinting1.40612720
45MP0002234_abnormal_pharynx_morphology1.39063271
46MP0010386_abnormal_urinary_bladder1.38795270
47MP0008932_abnormal_embryonic_tissue1.35510691
48MP0005408_hypopigmentation1.35213949
49MP0002751_abnormal_autonomic_nervous1.34223917
50MP0002064_seizures1.33847932
51MP0001486_abnormal_startle_reflex1.33794670
52MP0000015_abnormal_ear_pigmentation1.32187932
53MP0004957_abnormal_blastocyst_morpholog1.31661833
54MP0004270_analgesia1.30314302
55MP0002095_abnormal_skin_pigmentation1.28288532
56MP0006036_abnormal_mitochondrial_physio1.27718055
57MP0005075_abnormal_melanosome_morpholog1.24835362
58MP0002160_abnormal_reproductive_system1.23876506
59MP0000427_abnormal_hair_cycle1.22709701
60MP0003937_abnormal_limbs/digits/tail_de1.22508211
61MP0003718_maternal_effect1.22457618
62MP0006035_abnormal_mitochondrial_morpho1.22160718
63MP0006072_abnormal_retinal_apoptosis1.21243081
64MP0001485_abnormal_pinna_reflex1.19548962
65MP0002938_white_spotting1.19138092
66MP0002067_abnormal_sensory_capabilities1.17614044
67MP0000358_abnormal_cell_content/1.16624698
68MP0001963_abnormal_hearing_physiology1.16490450
69MP0005646_abnormal_pituitary_gland1.15583431
70MP0003724_increased_susceptibility_to1.15417831
71MP0005671_abnormal_response_to1.14335083
72MP0002572_abnormal_emotion/affect_behav1.14140764
73MP0004742_abnormal_vestibular_system1.13258278
74MP0002148_abnormal_hypersensitivity_rea1.13257083
75MP0001293_anophthalmia1.12982806
76MP0002837_dystrophic_cardiac_calcinosis1.12716250
77MP0003077_abnormal_cell_cycle1.09432058
78MP0001697_abnormal_embryo_size1.09152529
79MP0002233_abnormal_nose_morphology1.08835119
80MP0001984_abnormal_olfaction1.07642313
81MP0008260_abnormal_autophagy1.05750269
82MP0001970_abnormal_pain_threshold1.05655409
83MP0005551_abnormal_eye_electrophysiolog1.05211535
84MP0000631_abnormal_neuroendocrine_gland1.05026425
85MP0008875_abnormal_xenobiotic_pharmacok1.04943168
86MP0003186_abnormal_redox_activity1.04601107
87MP0003786_premature_aging1.04543808
88MP0009780_abnormal_chondrocyte_physiolo1.03299966
89MP0002090_abnormal_vision1.02175098
90MP0003315_abnormal_perineum_morphology1.01477909
91MP0001929_abnormal_gametogenesis1.00940650
92MP0000647_abnormal_sebaceous_gland0.99646011
93MP0001730_embryonic_growth_arrest0.99158110
94MP0004215_abnormal_myocardial_fiber0.98687583
95MP0000920_abnormal_myelination0.98017806
96MP0003635_abnormal_synaptic_transmissio0.97596023
97MP0004133_heterotaxia0.97034898
98MP0002210_abnormal_sex_determination0.96934508
99MP0000026_abnormal_inner_ear0.96762674
100MP0003890_abnormal_embryonic-extraembry0.96683057
101MP0003123_paternal_imprinting0.96607977
102MP0002822_catalepsy0.94657013
103MP0001764_abnormal_homeostasis0.94426500
104MP0003252_abnormal_bile_duct0.94011427
105MP0005386_behavior/neurological_phenoty0.93548705
106MP0004924_abnormal_behavior0.93548705
107MP0005084_abnormal_gallbladder_morpholo0.93411987
108MP0001501_abnormal_sleep_pattern0.93252385
109MP0001672_abnormal_embryogenesis/_devel0.92822953
110MP0005380_embryogenesis_phenotype0.92822953
111MP0000653_abnormal_sex_gland0.92059715
112MP0005253_abnormal_eye_physiology0.91166353
113MP0004043_abnormal_pH_regulation0.91014329
114MP0000350_abnormal_cell_proliferation0.90839748
115MP0003111_abnormal_nucleus_morphology0.90190023
116MP0001145_abnormal_male_reproductive0.88322671
117MP0002277_abnormal_respiratory_mucosa0.88054938
118MP0002084_abnormal_developmental_patter0.85340915
119MP0001664_abnormal_digestion0.85193727
120MP0002557_abnormal_social/conspecific_i0.83335001
121MP0005499_abnormal_olfactory_system0.82737794
122MP0005394_taste/olfaction_phenotype0.82737794
123MP0005389_reproductive_system_phenotype0.82176064
124MP0005395_other_phenotype0.81735826
125MP0005365_abnormal_bile_salt0.81397001
126MP0010307_abnormal_tumor_latency0.81292233
127MP0001666_abnormal_nutrient_absorption0.80538245
128MP0003011_delayed_dark_adaptation0.80046148
129MP0001440_abnormal_grooming_behavior0.78683063
130MP0003941_abnormal_skin_development0.78428926
131MP0008872_abnormal_physiological_respon0.78227860
132MP0002009_preneoplasia0.78227014
133MP0009785_altered_susceptibility_to0.78199558
134MP0005174_abnormal_tail_pigmentation0.78176376
135MP0002229_neurodegeneration0.77397949
136MP0003943_abnormal_hepatobiliary_system0.77199614
137MP0002088_abnormal_embryonic_growth/wei0.76875157
138MP0005332_abnormal_amino_acid0.75778546
139MP0002063_abnormal_learning/memory/cond0.75462165
140MP0003984_embryonic_growth_retardation0.75251699
141MP0001346_abnormal_lacrimal_gland0.75201553
142MP0010678_abnormal_skin_adnexa0.75134596
143MP0003755_abnormal_palate_morphology0.74962262
144MP0003950_abnormal_plasma_membrane0.74790236
145MP0010234_abnormal_vibrissa_follicle0.74623097
146MP0001286_abnormal_eye_development0.74361657
147MP0002396_abnormal_hematopoietic_system0.74024455
148MP0003763_abnormal_thymus_physiology0.73585896
149MP0001835_abnormal_antigen_presentation0.73521862
150MP0003879_abnormal_hair_cell0.71740494
151MP0001119_abnormal_female_reproductive0.71669175
152MP0005220_abnormal_exocrine_pancreas0.71302867
153MP0002080_prenatal_lethality0.71234285
154MP0002184_abnormal_innervation0.69750946
155MP0000681_abnormal_thyroid_gland0.68618079
156MP0002085_abnormal_embryonic_tissue0.68554794
157MP0002282_abnormal_trachea_morphology0.68117959

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.09913306
2Mitochondrial inheritance (HP:0001427)4.64724693
3Abnormal mitochondria in muscle tissue (HP:0008316)4.54333643
4Hepatocellular necrosis (HP:0001404)4.23150103
5Progressive macrocephaly (HP:0004481)4.21225678
6Increased CSF lactate (HP:0002490)4.18890310
7Acute encephalopathy (HP:0006846)4.05996847
8Increased hepatocellular lipid droplets (HP:0006565)3.90438359
9Hepatic necrosis (HP:0002605)3.54833592
103-Methylglutaconic aciduria (HP:0003535)3.48823039
11Renal Fanconi syndrome (HP:0001994)3.46895782
12Hypothermia (HP:0002045)3.46124495
13Lipid accumulation in hepatocytes (HP:0006561)3.36709082
14Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.13957607
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.07038424
16Increased serum lactate (HP:0002151)3.03775588
17Hypoglycemic coma (HP:0001325)2.91620452
18Increased serum pyruvate (HP:0003542)2.90798686
19Abnormality of glycolysis (HP:0004366)2.90798686
20Abnormal hair whorl (HP:0010721)2.87467867
21Chromosomal breakage induced by crosslinking agents (HP:0003221)2.85962426
22Parakeratosis (HP:0001036)2.85905708
23Chromsome breakage (HP:0040012)2.84315844
24Abnormality of the labia minora (HP:0012880)2.82536222
25Exercise intolerance (HP:0003546)2.80434549
26Optic disc pallor (HP:0000543)2.74382448
27Type I transferrin isoform profile (HP:0003642)2.72034721
28Exertional dyspnea (HP:0002875)2.70630803
29Lactic acidosis (HP:0003128)2.67797794
30Aplastic anemia (HP:0001915)2.59128758
31Congenital, generalized hypertrichosis (HP:0004540)2.58898648
32Volvulus (HP:0002580)2.58635823
33Cerebral edema (HP:0002181)2.57957973
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.57192383
35Leukodystrophy (HP:0002415)2.56921660
36Abnormality of the ileum (HP:0001549)2.52685805
37Medial flaring of the eyebrow (HP:0010747)2.51289943
38Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.50604013
39Decreased activity of mitochondrial respiratory chain (HP:0008972)2.50604013
40Reticulocytopenia (HP:0001896)2.48502700
41Respiratory failure (HP:0002878)2.47474838
42Abnormality of methionine metabolism (HP:0010901)2.46807312
43Duplicated collecting system (HP:0000081)2.45875268
44Abnormality of renal resorption (HP:0011038)2.43217060
45Increased intramyocellular lipid droplets (HP:0012240)2.42240299
46Microvesicular hepatic steatosis (HP:0001414)2.40166820
47Hypoglycemic seizures (HP:0002173)2.38415563
48Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.37889836
49Neuroendocrine neoplasm (HP:0100634)2.35902798
50Nephrogenic diabetes insipidus (HP:0009806)2.29193949
51Pancreatic islet-cell hyperplasia (HP:0004510)2.27879066
52Ketoacidosis (HP:0001993)2.26755174
53Hyperinsulinemic hypoglycemia (HP:0000825)2.25052642
54Abnormality of the renal collecting system (HP:0004742)2.23933152
55Congenital primary aphakia (HP:0007707)2.23175476
56Cerebral hypomyelination (HP:0006808)2.22715135
57Aplasia/Hypoplasia of the tibia (HP:0005772)2.21505130
58Birth length less than 3rd percentile (HP:0003561)2.20033598
59Adrenal hypoplasia (HP:0000835)2.19493395
60Pendular nystagmus (HP:0012043)2.19024421
61Gait imbalance (HP:0002141)2.18357373
62Colon cancer (HP:0003003)2.18333206
63Prostate neoplasm (HP:0100787)2.16947303
64Respiratory difficulties (HP:0002880)2.14991867
65IgM deficiency (HP:0002850)2.12420246
66Abnormality of aspartate family amino acid metabolism (HP:0010899)2.11414374
67Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.11192020
68Abnormality of alanine metabolism (HP:0010916)2.11192020
69Hyperalaninemia (HP:0003348)2.11192020
70Degeneration of anterior horn cells (HP:0002398)2.09657258
71Abnormality of the anterior horn cell (HP:0006802)2.09657258
72Abnormality of the heme biosynthetic pathway (HP:0010472)2.08790162
73Abnormality of the preputium (HP:0100587)2.07811986
74Sloping forehead (HP:0000340)2.07524452
75Abnormality of the renal cortex (HP:0011035)2.05699168
76Duodenal stenosis (HP:0100867)2.03338203
77Small intestinal stenosis (HP:0012848)2.03338203
78Lethargy (HP:0001254)2.03160612
79Pancreatic fibrosis (HP:0100732)2.02934782
80True hermaphroditism (HP:0010459)2.00071937
81Genital tract atresia (HP:0001827)1.99922748
82Methylmalonic aciduria (HP:0012120)1.99734224
83Short tibia (HP:0005736)1.99275000
84Vaginal atresia (HP:0000148)1.97432075
85Aplasia/Hypoplasia of the sacrum (HP:0008517)1.96302564
86Pheochromocytoma (HP:0002666)1.95837699
87Symptomatic seizures (HP:0011145)1.94985196
88Aplasia/Hypoplasia of the tongue (HP:0010295)1.93575231
89Microglossia (HP:0000171)1.92673410
90Abnormal number of erythroid precursors (HP:0012131)1.92607572
91Focal motor seizures (HP:0011153)1.92469900
92Pancytopenia (HP:0001876)1.90195905
93Ependymoma (HP:0002888)1.88095003
94Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87517333
95Pancreatic cysts (HP:0001737)1.86267620
96Nephronophthisis (HP:0000090)1.85096677
97Tubulointerstitial nephritis (HP:0001970)1.84957084
98Reduced antithrombin III activity (HP:0001976)1.84851993
99Abnormal lung lobation (HP:0002101)1.83730016
100Renal tubular dysfunction (HP:0000124)1.83693443
101Abnormality of cells of the erythroid lineage (HP:0012130)1.83486527
102Abnormal protein glycosylation (HP:0012346)1.83050385
103Abnormal glycosylation (HP:0012345)1.83050385
104Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83050385
105Abnormal protein N-linked glycosylation (HP:0012347)1.83050385
106Aplasia/hypoplasia of the uterus (HP:0008684)1.82598546
107Increased muscle lipid content (HP:0009058)1.81753986
108Autoamputation (HP:0001218)1.80024857
109Abnormality of the duodenum (HP:0002246)1.79288153
110Abnormality of endocrine pancreas physiology (HP:0012093)1.77656178
111Abnormality of the pancreatic islet cells (HP:0006476)1.77656178
112Abnormality of chromosome stability (HP:0003220)1.77188657
113Megaloblastic anemia (HP:0001889)1.76914230
114X-linked dominant inheritance (HP:0001423)1.76203704
115Myelodysplasia (HP:0002863)1.74821059
116Gaze-evoked nystagmus (HP:0000640)1.74653504
117Molar tooth sign on MRI (HP:0002419)1.74621154
118Abnormality of midbrain morphology (HP:0002418)1.74621154
119Abnormal respiratory epithelium morphology (HP:0012253)1.73894347
120Abnormal respiratory motile cilium morphology (HP:0005938)1.73894347
121Metaphyseal dysplasia (HP:0100255)1.73764781
122Glioma (HP:0009733)1.72892756
123Sclerocornea (HP:0000647)1.72188360
124Limb dystonia (HP:0002451)1.71375460
125Abnormality of serum amino acid levels (HP:0003112)1.70972416
126Patchy hypopigmentation of hair (HP:0011365)1.69364838
127Ketosis (HP:0001946)1.69241364
128Abnormality of urine glucose concentration (HP:0011016)1.68111095
129Glycosuria (HP:0003076)1.68111095
130Abnormality of secondary sexual hair (HP:0009888)1.67983580
131Abnormality of the axillary hair (HP:0100134)1.67983580
132Generalized aminoaciduria (HP:0002909)1.66594275
133Nephroblastoma (Wilms tumor) (HP:0002667)1.66107381
134CNS demyelination (HP:0007305)1.66034608
135Macrocytic anemia (HP:0001972)1.65820856
136Renal cortical cysts (HP:0000803)1.64746811
137Sensory axonal neuropathy (HP:0003390)1.63782706
138Febrile seizures (HP:0002373)1.63184638
139Retinal dysplasia (HP:0007973)1.62985863
140Methylmalonic acidemia (HP:0002912)1.60273301
141CNS hypomyelination (HP:0003429)1.59344226
142Pallor (HP:0000980)1.59271812
143Meckel diverticulum (HP:0002245)1.58124748
144Emotional lability (HP:0000712)1.55220261

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.29608286
2CASK3.48954683
3NEK12.70524502
4TNIK2.35548660
5VRK22.28312432
6EIF2AK32.21025481
7EIF2AK12.16844524
8VRK12.15786488
9SRPK12.15136474
10TRIM282.09719522
11MAP3K122.06573325
12BUB12.03827446
13PBK1.95236406
14MKNK21.92785888
15FRK1.92356276
16BMPR1B1.81843465
17IRAK41.76300159
18MKNK11.75651802
19NME11.75222856
20MAP2K71.69457983
21ERBB31.62298462
22OXSR11.61440537
23ADRBK21.60689416
24ZAK1.59610724
25MST41.58919113
26TSSK61.56110866
27YES11.45209702
28WEE11.44876657
29PDK21.44409049
30PLK41.43209769
31TXK1.33357167
32EIF2AK21.31742031
33STK38L1.31528446
34TLK11.30595106
35MAP4K21.29985305
36BLK1.29307381
37IRAK31.27795659
38STK391.27077121
39MAPKAPK51.26281678
40GRK71.24856194
41CCNB11.23021783
42NEK61.21222905
43CDK191.18905996
44PLK21.14758675
45BCR1.13293096
46CDK81.09581954
47PNCK1.07633376
48BMPR21.07237893
49PLK31.06090478
50BRSK21.05283279
51SIK31.01915728
52IRAK21.01633514
53PRPF4B0.98791540
54MUSK0.98766631
55TEC0.98736845
56BRAF0.94283064
57NME20.94248351
58MAPK130.93547926
59ARAF0.93213728
60CSNK1G30.91943206
61CDC70.91924322
62PHKG20.90182615
63PHKG10.90182615
64TAF10.84550449
65MST1R0.84267824
66BCKDK0.83235091
67MAP3K140.82333381
68AKT30.81837602
69OBSCN0.80266800
70PIK3CG0.79041808
71WNK40.78744462
72DAPK10.78249849
73MAP3K40.76864741
74PKN10.75089817
75PASK0.73888594
76GRK50.72206865
77GRK10.71546345
78PINK10.71408842
79LIMK10.70417490
80NUAK10.70216191
81PIM20.70002711
82CAMK2B0.69760988
83ACVR1B0.69461971
84ATM0.67709946
85TNK20.63036056
86SCYL20.62694545
87CDK30.62085548
88CSNK1G10.59060089
89AURKA0.59001366
90PRKCE0.58610749
91ATR0.57872809
92CLK10.56434908
93INSRR0.56300804
94LYN0.55774102
95CSNK2A10.54981517
96RPS6KA50.54724754
97DYRK20.54703826
98MYLK0.51962456
99NTRK30.51061138
100PRKCI0.50905631
101ADRBK10.50839246
102ALK0.50807305
103PLK10.50679814
104IRAK10.50566613
105CSNK1G20.50509452
106CHEK10.49843690
107BRSK10.48931485
108TESK20.47671478
109FGFR10.46795088
110PIK3CA0.46769053
111ERBB40.46489856
112CHEK20.45699323
113CSNK2A20.44708531
114TAOK30.44691789
115KIT0.43990156
116TTK0.41713115
117STK30.41699319
118CAMK2D0.41624921
119PAK30.41241104
120SYK0.40305407
121PRKCG0.40125525
122MINK10.38709464
123AURKB0.38586459
124UHMK10.38173979
125WNK30.38105779
126CAMK2A0.37968186
127STK240.37399922
128PRKCQ0.37080244
129CSNK1A1L0.36905729
130CSNK1E0.36705159
131STK100.35943353
132MAPKAPK30.35271069
133CSNK1A10.34686824
134FER0.34029842
135NEK20.33115216
136CDK90.32791324
137PAK40.31569542
138RPS6KB20.31528341
139TGFBR10.30579116

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.27938989
2Proteasome_Homo sapiens_hsa030504.00159638
3Protein export_Homo sapiens_hsa030603.77104836
4Parkinsons disease_Homo sapiens_hsa050123.61256467
5RNA polymerase_Homo sapiens_hsa030203.26608545
6Ribosome_Homo sapiens_hsa030103.13044480
7Mismatch repair_Homo sapiens_hsa034302.62499621
8Alzheimers disease_Homo sapiens_hsa050102.58480459
9DNA replication_Homo sapiens_hsa030302.54038908
10Huntingtons disease_Homo sapiens_hsa050162.51677641
11Homologous recombination_Homo sapiens_hsa034402.37086826
12Pyrimidine metabolism_Homo sapiens_hsa002402.08566939
13Propanoate metabolism_Homo sapiens_hsa006402.03130344
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.00758018
15Nucleotide excision repair_Homo sapiens_hsa034201.95434231
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.93021332
17Non-homologous end-joining_Homo sapiens_hsa034501.90549276
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.80728715
19Fanconi anemia pathway_Homo sapiens_hsa034601.80137116
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75545929
21Spliceosome_Homo sapiens_hsa030401.73199067
22Basal transcription factors_Homo sapiens_hsa030221.67872613
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63461259
24Collecting duct acid secretion_Homo sapiens_hsa049661.60849823
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59835027
26RNA degradation_Homo sapiens_hsa030181.56394197
27Purine metabolism_Homo sapiens_hsa002301.41958478
28Fatty acid elongation_Homo sapiens_hsa000621.40520423
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.39049275
30Selenocompound metabolism_Homo sapiens_hsa004501.36298834
31Nicotine addiction_Homo sapiens_hsa050331.33527904
32Butanoate metabolism_Homo sapiens_hsa006501.30684845
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27313597
34Base excision repair_Homo sapiens_hsa034101.26539970
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20920555
36Vibrio cholerae infection_Homo sapiens_hsa051101.20519651
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18206443
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17959694
39Phototransduction_Homo sapiens_hsa047441.08959942
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08808612
41Pentose and glucuronate interconversions_Homo sapiens_hsa000401.06014618
42Steroid biosynthesis_Homo sapiens_hsa001001.04251828
43Cardiac muscle contraction_Homo sapiens_hsa042601.01892320
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00554799
45Sulfur metabolism_Homo sapiens_hsa009201.00163503
46Ether lipid metabolism_Homo sapiens_hsa005650.99030132
47Primary bile acid biosynthesis_Homo sapiens_hsa001200.94136677
48Autoimmune thyroid disease_Homo sapiens_hsa053200.93604536
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92271559
50Serotonergic synapse_Homo sapiens_hsa047260.90433586
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89594576
52Caffeine metabolism_Homo sapiens_hsa002320.87752847
53Rheumatoid arthritis_Homo sapiens_hsa053230.86921597
54RNA transport_Homo sapiens_hsa030130.86642105
55Carbon metabolism_Homo sapiens_hsa012000.86484139
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85802291
57Sphingolipid metabolism_Homo sapiens_hsa006000.84728593
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84002122
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81184749
60Graft-versus-host disease_Homo sapiens_hsa053320.80746413
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80427764
62Fatty acid degradation_Homo sapiens_hsa000710.80370534
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80042760
64Arachidonic acid metabolism_Homo sapiens_hsa005900.79922725
65Cell cycle_Homo sapiens_hsa041100.77542775
66Metabolic pathways_Homo sapiens_hsa011000.76480285
67Fatty acid metabolism_Homo sapiens_hsa012120.75674604
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.74360295
69Taste transduction_Homo sapiens_hsa047420.73604713
70Tryptophan metabolism_Homo sapiens_hsa003800.73440130
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72862396
72Synaptic vesicle cycle_Homo sapiens_hsa047210.71717999
73Allograft rejection_Homo sapiens_hsa053300.69601626
74Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69252067
75Linoleic acid metabolism_Homo sapiens_hsa005910.67645809
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67498530
77beta-Alanine metabolism_Homo sapiens_hsa004100.66239751
78Oocyte meiosis_Homo sapiens_hsa041140.63711104
79Other glycan degradation_Homo sapiens_hsa005110.61092180
80Primary immunodeficiency_Homo sapiens_hsa053400.61047690
81Biosynthesis of amino acids_Homo sapiens_hsa012300.60631287
82Glutathione metabolism_Homo sapiens_hsa004800.60292154
83Phagosome_Homo sapiens_hsa041450.59837501
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59162059
85Asthma_Homo sapiens_hsa053100.58083156
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.57779649
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57124580
88Retinol metabolism_Homo sapiens_hsa008300.56333043
89Morphine addiction_Homo sapiens_hsa050320.56330177
90Epstein-Barr virus infection_Homo sapiens_hsa051690.56024658
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55595733
92Folate biosynthesis_Homo sapiens_hsa007900.54812804
93Chemical carcinogenesis_Homo sapiens_hsa052040.54233897
94Regulation of autophagy_Homo sapiens_hsa041400.54202054
95Type I diabetes mellitus_Homo sapiens_hsa049400.54050899
96One carbon pool by folate_Homo sapiens_hsa006700.51573124
97Nitrogen metabolism_Homo sapiens_hsa009100.50400248
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.48746260
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48663354
100p53 signaling pathway_Homo sapiens_hsa041150.47421942
101Tyrosine metabolism_Homo sapiens_hsa003500.46094650
102GABAergic synapse_Homo sapiens_hsa047270.45875024
103Arginine and proline metabolism_Homo sapiens_hsa003300.45717581
104Phenylalanine metabolism_Homo sapiens_hsa003600.44159958
105Alcoholism_Homo sapiens_hsa050340.43342417
106Hematopoietic cell lineage_Homo sapiens_hsa046400.42366432
107Histidine metabolism_Homo sapiens_hsa003400.41942069
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41510424
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41396406
110Systemic lupus erythematosus_Homo sapiens_hsa053220.41231757
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.40712501
112Vitamin B6 metabolism_Homo sapiens_hsa007500.39707859
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38976840
114Pentose phosphate pathway_Homo sapiens_hsa000300.38493169
115Amphetamine addiction_Homo sapiens_hsa050310.36756034
116Pyruvate metabolism_Homo sapiens_hsa006200.36423918
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.32726421
118Pancreatic secretion_Homo sapiens_hsa049720.32044888
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31955548
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30979951
121mRNA surveillance pathway_Homo sapiens_hsa030150.27271002
122Starch and sucrose metabolism_Homo sapiens_hsa005000.26956481
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26311067
124Glutamatergic synapse_Homo sapiens_hsa047240.26107413
125Dopaminergic synapse_Homo sapiens_hsa047280.24692257
126Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24653927
127Vitamin digestion and absorption_Homo sapiens_hsa049770.23172051
128N-Glycan biosynthesis_Homo sapiens_hsa005100.23018456
129Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.19852035
130Lysine degradation_Homo sapiens_hsa003100.19466136
131Antigen processing and presentation_Homo sapiens_hsa046120.18510087
132Glycerolipid metabolism_Homo sapiens_hsa005610.18367338
133Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.17999989
134Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.17932412
135Circadian entrainment_Homo sapiens_hsa047130.17891880
136TGF-beta signaling pathway_Homo sapiens_hsa043500.17576139
137Peroxisome_Homo sapiens_hsa041460.16602415
138Mineral absorption_Homo sapiens_hsa049780.16148868
139NOD-like receptor signaling pathway_Homo sapiens_hsa046210.12841434
140Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12010809

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