ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm motility (GO:0030317)	8.20727901
2	cellular ketone body metabolic process (GO:0046950)	7.08746551
3	fusion of sperm to egg plasma membrane (GO:0007342)	6.76299006
4	ketone body metabolic process (GO:1902224)	6.58119689
5	rRNA methylation (GO:0031167)	6.30278059
6	protein targeting to Golgi (GO:0000042)	6.13586833
7	establishment of protein localization to Golgi (GO:0072600)	5.98768513
8	rRNA modification (GO:0000154)	5.96758220
9	protein polyglutamylation (GO:0018095)	5.93465016
10	single strand break repair (GO:0000012)	5.74923520
11	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.65643767
12	spermatid development (GO:0007286)	5.63350234
13	acrosome reaction (GO:0007340)	5.48291878
14	centriole replication (GO:0007099)	5.33738142
15	DNA packaging (GO:0006323)	5.30685819
16	seminiferous tubule development (GO:0072520)	5.30623823
17	chromosome condensation (GO:0030261)	5.26483662
18	regulation of centriole replication (GO:0046599)	5.20834472
19	microtubule depolymerization (GO:0007019)	5.11525285
20	tRNA methylation (GO:0030488)	5.02847385
21	sperm-egg recognition (GO:0035036)	4.95634995
22	microtubule polymerization or depolymerization (GO:0031109)	4.90951222
23	plasma membrane fusion (GO:0045026)	4.87222336
24	spermatid nucleus differentiation (GO:0007289)	4.83500076
25	binding of sperm to zona pellucida (GO:0007339)	4.78152885
26	spermatogenesis (GO:0007283)	4.77469908
27	male gamete generation (GO:0048232)	4.76895698
28	centriole assembly (GO:0098534)	4.57833346
29	nuclear pore complex assembly (GO:0051292)	4.45073247
30	response to pheromone (GO:0019236)	4.41865479
31	multicellular organism reproduction (GO:0032504)	4.41694464
32	gamete generation (GO:0007276)	4.41414079
33	protein localization to Golgi apparatus (GO:0034067)	4.39575248
34	sperm capacitation (GO:0048240)	4.13286564
35	microtubule nucleation (GO:0007020)	4.11795978
36	cell-cell recognition (GO:0009988)	3.98182245
37	regulation of cholesterol esterification (GO:0010872)	3.92500470
38	regulation of cytokine secretion involved in immune response (GO:0002739)	3.82336795
39	cell wall macromolecule catabolic process (GO:0016998)	3.76875044
40	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	3.76372817
41	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	3.74773181
42	nuclear pore organization (GO:0006999)	3.73626921
43	regulation of retinoic acid receptor signaling pathway (GO:0048385)	3.69180807
44	cell wall macromolecule metabolic process (GO:0044036)	3.64405482
45	cilium or flagellum-dependent cell motility (GO:0001539)	3.61586753
46	reproduction (GO:0000003)	3.60253205
47	single fertilization (GO:0007338)	3.57023879
48	ribosome assembly (GO:0042255)	3.55541312
49	regulation of meiosis I (GO:0060631)	3.54177407
50	plasma lipoprotein particle assembly (GO:0034377)	3.52682996
51	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.48226521
52	high-density lipoprotein particle remodeling (GO:0034375)	3.45041494
53	multicellular organismal reproductive process (GO:0048609)	3.44811356
54	fertilization (GO:0009566)	3.42245288
55	acrosome assembly (GO:0001675)	3.40883982
56	phosphatidylethanolamine metabolic process (GO:0046337)	3.31604943
57	RNA methylation (GO:0001510)	3.30091930
58	regulation of cilium movement (GO:0003352)	3.27721206
59	phospholipid efflux (GO:0033700)	3.25397615
60	germ cell development (GO:0007281)	3.24146790
61	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.20937236
62	intra-Golgi vesicle-mediated transport (GO:0006891)	3.18716257
63	pore complex assembly (GO:0046931)	3.17686553
64	glycerol ether metabolic process (GO:0006662)	3.17479354
65	calcium ion-dependent exocytosis (GO:0017156)	3.13756870
66	axonemal dynein complex assembly (GO:0070286)	3.13657333
67	regulation of acyl-CoA biosynthetic process (GO:0050812)	3.13567136
68	epithelial cilium movement (GO:0003351)	3.13518603
69	microtubule severing (GO:0051013)	3.11703776
70	mitochondrial fission (GO:0000266)	3.11683569
71	nucleus organization (GO:0006997)	3.11607730
72	positive regulation of protein targeting to membrane (GO:0090314)	3.10572871
73	intestinal cholesterol absorption (GO:0030299)	3.07386744
74	negative regulation of dendrite morphogenesis (GO:0050774)	3.03591541
75	replication fork processing (GO:0031297)	3.02279133
76	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.99708665
77	cholesterol efflux (GO:0033344)	2.99351594
78	cellular process involved in reproduction in multicellular organism (GO:0022412)	2.98627807
79	ovulation from ovarian follicle (GO:0001542)	2.95903673
80	glomerular visceral epithelial cell development (GO:0072015)	2.95257111
81	ether metabolic process (GO:0018904)	2.88356511
82	male meiosis I (GO:0007141)	2.87745538
83	phosphatidylcholine biosynthetic process (GO:0006656)	2.86322856
84	protein-lipid complex assembly (GO:0065005)	2.82164039
85	DNA strand renaturation (GO:0000733)	2.81897038
86	cholesterol biosynthetic process (GO:0006695)	2.75918283
87	regulation of cofactor metabolic process (GO:0051193)	2.75782415
88	regulation of coenzyme metabolic process (GO:0051196)	2.75782415
89	glutathione metabolic process (GO:0006749)	2.74228683
90	RNA localization (GO:0006403)	2.73906469
91	piRNA metabolic process (GO:0034587)	2.72957950
92	histone H3-K4 trimethylation (GO:0080182)	2.72591550
93	regulation of centrosome duplication (GO:0010824)	2.71397525
94	reverse cholesterol transport (GO:0043691)	2.70083285
95	axoneme assembly (GO:0035082)	2.67810009
96	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	2.62901521
97	amine catabolic process (GO:0009310)	2.60830245
98	cellular biogenic amine catabolic process (GO:0042402)	2.60830245
99	glutathione derivative metabolic process (GO:1901685)	2.60594958
100	glutathione derivative biosynthetic process (GO:1901687)	2.60594958

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.83767348
2	E2F7_22180533_ChIP-Seq_HELA_Human	3.32544327
3	FUS_26573619_Chip-Seq_HEK293_Human	3.31882924
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.21175466
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.15043191
6	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.77200551
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.63960709
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.51821457
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.45532823
10	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.33583192
11	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.32597384
12	CBP_20019798_ChIP-Seq_JUKART_Human	2.32597384
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.14080281
14	P300_19829295_ChIP-Seq_ESCs_Human	2.05603738
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.05043208
16	ER_23166858_ChIP-Seq_MCF-7_Human	2.02592805
17	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.98574475
18	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.98574475
19	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.95905651
20	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.86128027
21	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.83218643
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.80853139
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.76890208
24	VDR_22108803_ChIP-Seq_LS180_Human	1.74132847
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.72885080
26	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.69986524
27	RBPJ_21746931_ChIP-Seq_IB4_Human	1.57531054
28	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.57185882
29	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.55592700
30	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.52784969
31	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.52439636
32	STAT3_23295773_ChIP-Seq_U87_Human	1.52365558
33	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.51098709
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.49521575
35	NANOG_19829295_ChIP-Seq_ESCs_Human	1.48148676
36	SOX2_19829295_ChIP-Seq_ESCs_Human	1.48148676
37	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.46666283
38	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.46529269
39	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.45588570
40	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.44747012
41	GBX2_23144817_ChIP-Seq_PC3_Human	1.44189898
42	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.44185888
43	PHF8_20622853_ChIP-Seq_HELA_Human	1.43386275
44	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.42756042
45	MYC_19829295_ChIP-Seq_ESCs_Human	1.42675578
46	ETV1_20927104_ChIP-Seq_GIST48_Human	1.42424276
47	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.41741149
48	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.41565308
49	HOXB7_26014856_ChIP-Seq_BT474_Human	1.39014079
50	ELK1_19687146_ChIP-ChIP_HELA_Human	1.39001734
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.38351160
52	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.36491392
53	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.36279753
54	TCF4_22108803_ChIP-Seq_LS180_Human	1.34804493
55	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.34081086
56	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.32713536
57	AR_25329375_ChIP-Seq_VCAP_Human	1.32324837
58	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.32185537
59	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.31446437
60	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.30890127
61	TAF15_26573619_Chip-Seq_HEK293_Human	1.30220196
62	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.29721448
63	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.28099126
64	NFYB_21822215_ChIP-Seq_K562_Human	1.27088731
65	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.26603044
66	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.24738898
67	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.24738898
68	RUNX2_22187159_ChIP-Seq_PCA_Human	1.24480502
69	TCF4_23295773_ChIP-Seq_U87_Human	1.22315937
70	SMAD4_21799915_ChIP-Seq_A2780_Human	1.20336693
71	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.19369218
72	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.18252747
73	TBL1_22424771_ChIP-Seq_293T_Human	1.17081877
74	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.16117587
75	NCOR_22424771_ChIP-Seq_293T_Human	1.14619529
76	CDX2_22108803_ChIP-Seq_LS180_Human	1.14022351
77	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.13934594
78	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.11977954
79	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.11865133
80	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.10995002
81	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.10792939
82	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.09318770
83	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.06082781
84	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.05367666
85	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.04909997
86	TP53_22573176_ChIP-Seq_HFKS_Human	1.04104878
87	IGF1R_20145208_ChIP-Seq_DFB_Human	1.04018506
88	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.03635810
89	EZH2_22144423_ChIP-Seq_EOC_Human	1.02976169
90	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.02948968
91	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.00952943
92	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.99717222
93	ERG_20517297_ChIP-Seq_VCAP_Human	0.98837729
94	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.98195185
95	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.97068365
96	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.96215138
97	NANOG_20526341_ChIP-Seq_ESCs_Human	0.94610066
98	NFYA_21822215_ChIP-Seq_K562_Human	0.94579438
99	CEBPB_22108803_ChIP-Seq_LS180_Human	0.94490478
100	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.94170791

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	6.71105979
2	MP0008877_abnormal_DNA_methylation	4.30235712
3	MP0001986_abnormal_taste_sensitivity	4.28339566
4	MP0001929_abnormal_gametogenesis	3.23623136
5	MP0005377_hearing/vestibular/ear_phenot	3.13191933
6	MP0003878_abnormal_ear_physiology	3.13191933
7	MP0008057_abnormal_DNA_replication	3.08949528
8	MP0008995_early_reproductive_senescence	3.06068427
9	MP0003698_abnormal_male_reproductive	3.04846016
10	MP0009697_abnormal_copulation	2.90589439
11	MP0005670_abnormal_white_adipose	2.52220202
12	MP0003718_maternal_effect	2.49008210
13	MP0008058_abnormal_DNA_repair	2.11509561
14	MP0006292_abnormal_olfactory_placode	1.99756793
15	MP0002161_abnormal_fertility/fecundity	1.83681445
16	MP0002210_abnormal_sex_determination	1.80591571
17	MP0005365_abnormal_bile_salt	1.79408080
18	MP0005408_hypopigmentation	1.74543214
19	MP0010094_abnormal_chromosome_stability	1.72368759
20	MP0003787_abnormal_imprinting	1.68737819
21	MP0004957_abnormal_blastocyst_morpholog	1.64354043
22	MP0001485_abnormal_pinna_reflex	1.62090248
23	MP0005367_renal/urinary_system_phenotyp	1.61422491
24	MP0000516_abnormal_urinary_system	1.61422491
25	MP0009840_abnormal_foam_cell	1.60602995
26	MP0000653_abnormal_sex_gland	1.58013104
27	MP0003646_muscle_fatigue	1.57472554
28	MP0005310_abnormal_salivary_gland	1.56914068
29	MP0003786_premature_aging	1.56324867
30	MP0010329_abnormal_lipoprotein_level	1.53395270
31	MP0001145_abnormal_male_reproductive	1.52761139
32	MP0000372_irregular_coat_pigmentation	1.49755502
33	MP0005551_abnormal_eye_electrophysiolog	1.44104004
34	MP0003077_abnormal_cell_cycle	1.42680198
35	MP0002736_abnormal_nociception_after	1.41794712
36	MP0003121_genomic_imprinting	1.39596599
37	MP0005379_endocrine/exocrine_gland_phen	1.36863695
38	MP0005084_abnormal_gallbladder_morpholo	1.28711822
39	MP0004142_abnormal_muscle_tone	1.28053877
40	MP0003122_maternal_imprinting	1.26549632
41	MP0001984_abnormal_olfaction	1.25447807
42	MP0001486_abnormal_startle_reflex	1.23628866
43	MP0002132_abnormal_respiratory_system	1.22500139
44	MP0001968_abnormal_touch/_nociception	1.21821886
45	MP0001293_anophthalmia	1.20278383
46	MP0002876_abnormal_thyroid_physiology	1.15351886
47	MP0010307_abnormal_tumor_latency	1.12634880
48	MP0005395_other_phenotype	1.12303309
49	MP0005253_abnormal_eye_physiology	1.11151909
50	MP0002234_abnormal_pharynx_morphology	1.10526249
51	MP0003111_abnormal_nucleus_morphology	1.08342867
52	MP0001348_abnormal_lacrimal_gland	1.05661538
53	MP0000613_abnormal_salivary_gland	1.02818469
54	MP0003011_delayed_dark_adaptation	1.02510939
55	MP0002138_abnormal_hepatobiliary_system	1.01640045
56	MP0002102_abnormal_ear_morphology	1.01235668
57	MP0003699_abnormal_female_reproductive	1.00162606
58	MP0008872_abnormal_physiological_respon	0.97117199
59	MP0006276_abnormal_autonomic_nervous	0.93810397
60	MP0006035_abnormal_mitochondrial_morpho	0.92002346
61	MP0003693_abnormal_embryo_hatching	0.91634871
62	MP0003195_calcinosis	0.90378249
63	MP0006036_abnormal_mitochondrial_physio	0.90001837
64	MP0002938_white_spotting	0.87590894
65	MP0003137_abnormal_impulse_conducting	0.87294730
66	MP0001119_abnormal_female_reproductive	0.86336232
67	MP0005085_abnormal_gallbladder_physiolo	0.81751498
68	MP0002090_abnormal_vision	0.81123865
69	MP0003567_abnormal_fetal_cardiomyocyte	0.81061920
70	MP0001529_abnormal_vocalization	0.80717987
71	MP0005266_abnormal_metabolism	0.80587452
72	MP0001666_abnormal_nutrient_absorption	0.79623905
73	MP0000569_abnormal_digit_pigmentation	0.79355635
74	MP0005636_abnormal_mineral_homeostasis	0.79277842
75	MP0002127_abnormal_cardiovascular_syste	0.79008411
76	MP0001963_abnormal_hearing_physiology	0.78567517
77	MP0009115_abnormal_fat_cell	0.78549701
78	MP0004085_abnormal_heartbeat	0.76918558
79	MP0008007_abnormal_cellular_replicative	0.73359833
80	MP0001270_distended_abdomen	0.72580307
81	MP0000427_abnormal_hair_cycle	0.70204708
82	MP0004264_abnormal_extraembryonic_tissu	0.67007100
83	MP0004147_increased_porphyrin_level	0.66377015
84	MP0003806_abnormal_nucleotide_metabolis	0.66174037
85	MP0001764_abnormal_homeostasis	0.65691457
86	MP0000015_abnormal_ear_pigmentation	0.64301333
87	MP0008932_abnormal_embryonic_tissue	0.63448427
88	MP0005391_vision/eye_phenotype	0.61992368
89	MP0004742_abnormal_vestibular_system	0.61443869
90	MP0000639_abnormal_adrenal_gland	0.59022954
91	MP0005332_abnormal_amino_acid	0.58167878
92	MP0000538_abnormal_urinary_bladder	0.57966344
93	MP0002229_neurodegeneration	0.54163954
94	MP0001697_abnormal_embryo_size	0.54151021
95	MP0005647_abnormal_sex_gland	0.54085208
96	MP0005380_embryogenesis_phenotype	0.52574561
97	MP0001672_abnormal_embryogenesis/_devel	0.52574561
98	MP0003937_abnormal_limbs/digits/tail_de	0.50506780
99	MP0009046_muscle_twitch	0.49893836
100	MP0002069_abnormal_eating/drinking_beha	0.47843952

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chronic hepatic failure (HP:0100626)	6.69237920
2	Spontaneous abortion (HP:0005268)	4.98312623
3	Tubulointerstitial nephritis (HP:0001970)	4.17280128
4	Cone-rod dystrophy (HP:0000548)	3.96582149
5	Severe visual impairment (HP:0001141)	3.75215181
6	Hypoalphalipoproteinemia (HP:0003233)	3.51567664
7	Male infertility (HP:0003251)	3.43450106
8	Abnormality of dental color (HP:0011073)	3.33608026
9	Hypolipoproteinemia (HP:0010981)	3.27185487
10	Absent/shortened dynein arms (HP:0200106)	3.18587760
11	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.18587760
12	Abnormality of macular pigmentation (HP:0008002)	3.06907827
13	Attenuation of retinal blood vessels (HP:0007843)	3.04749193
14	Progressive inability to walk (HP:0002505)	3.00269351
15	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.97489441
16	Intestinal atresia (HP:0011100)	2.90521716
17	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.88522221
18	Abnormality of alanine metabolism (HP:0010916)	2.88522221
19	Hyperalaninemia (HP:0003348)	2.88522221
20	Pancreatic islet-cell hyperplasia (HP:0004510)	2.79531700
21	Subcapsular cataract (HP:0000523)	2.73497286
22	Menstrual irregularities (HP:0000858)	2.71951327
23	Chromsome breakage (HP:0040012)	2.68848573
24	Bony spicule pigmentary retinopathy (HP:0007737)	2.63031230
25	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.61160343
26	Hypoglycemic seizures (HP:0002173)	2.56435651
27	Hypobetalipoproteinemia (HP:0003563)	2.54969763
28	Glycosuria (HP:0003076)	2.54523823
29	Abnormality of urine glucose concentration (HP:0011016)	2.54523823
30	Resting tremor (HP:0002322)	2.49208312
31	Intellectual disability, moderate (HP:0002342)	2.48681472
32	Type 2 muscle fiber atrophy (HP:0003554)	2.45056673
33	Insulin-resistant diabetes mellitus (HP:0000831)	2.42752525
34	Abnormality of the nasal septum (HP:0000419)	2.41118488
35	Bifid tongue (HP:0010297)	2.41074481
36	Epidermoid cyst (HP:0200040)	2.39919749
37	Hypoglycemic coma (HP:0001325)	2.37401080
38	Intrahepatic cholestasis (HP:0001406)	2.34352504
39	Septate vagina (HP:0001153)	2.30781348
40	Gingival bleeding (HP:0000225)	2.20152558
41	Hypoalbuminemia (HP:0003073)	2.20130872
42	Abnormal albumin level (HP:0012116)	2.20130872
43	Gonadotropin excess (HP:0000837)	2.18823890
44	Infertility (HP:0000789)	2.17797925
45	Generalized aminoaciduria (HP:0002909)	2.14719129
46	Abnormality of the ileum (HP:0001549)	2.14571433
47	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.11337329
48	Multiple enchondromatosis (HP:0005701)	2.09069411
49	Meckel diverticulum (HP:0002245)	2.08519758
50	Abnormality of methionine metabolism (HP:0010901)	2.07175763
51	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.06955552
52	Abnormality of the parathyroid morphology (HP:0011766)	2.04197156
53	Abnormality of chromosome stability (HP:0003220)	2.02715853
54	Impulsivity (HP:0100710)	2.01942437
55	Acanthocytosis (HP:0001927)	1.99914319
56	Small intestinal stenosis (HP:0012848)	1.99888972
57	Duodenal stenosis (HP:0100867)	1.99888972
58	Muscle fiber atrophy (HP:0100295)	1.99085199
59	Nephronophthisis (HP:0000090)	1.97511693
60	Abnormality of the duodenum (HP:0002246)	1.95880788
61	Amelogenesis imperfecta (HP:0000705)	1.95861645
62	Abnormality of serum amino acid levels (HP:0003112)	1.95531426
63	Increased serum pyruvate (HP:0003542)	1.95216917
64	Abnormal spermatogenesis (HP:0008669)	1.92882918
65	Stage 5 chronic kidney disease (HP:0003774)	1.92567097
66	Glioma (HP:0009733)	1.91774665
67	Truncal obesity (HP:0001956)	1.91410108
68	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.91246668
69	Abnormality of the renal cortex (HP:0011035)	1.91041183
70	Abnormal respiratory motile cilium physiology (HP:0012261)	1.90177820
71	Abnormality of glycolysis (HP:0004366)	1.88788758
72	Abnormal respiratory motile cilium morphology (HP:0005938)	1.87776812
73	Abnormal respiratory epithelium morphology (HP:0012253)	1.87776812
74	Colon cancer (HP:0003003)	1.86838826
75	Abnormality of the renal medulla (HP:0100957)	1.86345809
76	Pancreatic cysts (HP:0001737)	1.85287474
77	Volvulus (HP:0002580)	1.83387227
78	Hyperkalemia (HP:0002153)	1.83280862
79	Duplicated collecting system (HP:0000081)	1.83221907
80	Abnormal ciliary motility (HP:0012262)	1.81865954
81	Broad alveolar ridges (HP:0000187)	1.79860362
82	Clubbing of toes (HP:0100760)	1.77810107
83	Symptomatic seizures (HP:0011145)	1.77637082
84	Hypophosphatemic rickets (HP:0004912)	1.75873503
85	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.75361511
86	Abnormality of the preputium (HP:0100587)	1.75092678
87	Facial cleft (HP:0002006)	1.74993155
88	Myelodysplasia (HP:0002863)	1.74150750
89	Gastrointestinal atresia (HP:0002589)	1.73878295
90	Abnormality of the renal collecting system (HP:0004742)	1.73498095
91	Portal hypertension (HP:0001409)	1.73497135
92	Abnormal lung lobation (HP:0002101)	1.72234023
93	Poikilocytosis (HP:0004447)	1.71860241
94	Megaloblastic anemia (HP:0001889)	1.71333071
95	Fat malabsorption (HP:0002630)	1.71002943
96	Renal cortical cysts (HP:0000803)	1.70925938
97	Renal Fanconi syndrome (HP:0001994)	1.69810507
98	Astrocytoma (HP:0009592)	1.69744946
99	Abnormality of the astrocytes (HP:0100707)	1.69744946
100	Hypergonadotropic hypogonadism (HP:0000815)	1.69232139

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	INSRR	5.88863060
2	PLK4	5.70432958
3	STK38L	4.63287103
4	PDK2	4.08594149
5	NUAK1	3.37323651
6	BRD4	3.13669738
7	MAP4K2	3.08270694
8	PIK3CG	2.81737122
9	PLK2	2.60576477
10	PNCK	2.39380784
11	STK24	2.15468280
12	FRK	2.15353874
13	CDK12	1.84264092
14	TESK2	1.84014850
15	TESK1	1.83506537
16	SRPK1	1.83363503
17	PBK	1.69598595
18	ERBB4	1.57099783
19	MAP3K12	1.55907970
20	CAMK1G	1.54246960
21	ZAK	1.53455406
22	BRSK2	1.53285332
23	TAF1	1.36836404
24	MST4	1.27680182
25	WNK3	1.20511063
26	BMPR1B	1.15549151
27	WEE1	1.08847661
28	CASK	1.07586655
29	CDC7	1.07145611
30	MUSK	1.06557326
31	STK39	1.05925093
32	STK3	1.05194694
33	EPHA2	0.98051327
34	VRK2	0.96689579
35	BRSK1	0.95167986
36	TRIM28	0.94338940
37	LATS1	0.90601747
38	TNIK	0.90143492
39	CDK7	0.88967758
40	OXSR1	0.88104936
41	AKT3	0.87268061
42	ACVR1B	0.84892399
43	MAP3K10	0.79885432
44	NEK6	0.76836976
45	TYRO3	0.76231032
46	CDK3	0.67797769
47	GRK1	0.67653362
48	PLK3	0.63916443
49	ATR	0.57004648
50	BCKDK	0.55928825
51	STK38	0.54945187
52	BUB1	0.54582157
53	DAPK1	0.54235128
54	TTK	0.51288455
55	PRKAA2	0.48530570
56	PAK3	0.47199074
57	VRK1	0.46499871
58	PDK1	0.45963919
59	CHEK1	0.45259795
60	CSNK1G1	0.42820702
61	SGK2	0.42630003
62	CAMK1D	0.41371135
63	MAPK11	0.41126027
64	CDK9	0.40400922
65	PLK1	0.39145329
66	EIF2AK1	0.36923854
67	SGK494	0.36750523
68	SGK223	0.36750523
69	NME1	0.36477241
70	CSNK1A1	0.35883525
71	PRKCG	0.34940543
72	NLK	0.34248126
73	EIF2AK3	0.34188654
74	RPS6KA4	0.33052121
75	PDPK1	0.31345275
76	SGK3	0.31254508
77	TAOK3	0.31235186
78	ATM	0.31048298
79	WNK1	0.28971520
80	CHEK2	0.27787868
81	PRKD3	0.27730432
82	DDR2	0.25690087
83	CDK2	0.25503627
84	DYRK3	0.25075222
85	MAP3K4	0.23948573
86	PTK2B	0.23907860
87	PRKCE	0.23891561
88	TSSK6	0.23556569
89	EIF2AK2	0.22810404
90	ADRBK2	0.21476143
91	CSNK1A1L	0.20418435
92	CDK1	0.20289007
93	PINK1	0.19048610
94	FGFR2	0.18719540
95	PRKG1	0.18306004
96	PHKG2	0.18281971
97	PHKG1	0.18281971
98	CSNK2A2	0.18195342
99	BLK	0.17844592
100	PRKCB	0.16171781

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	7.11827028
2	Butanoate metabolism_Homo sapiens_hsa00650	3.16710535
3	RNA transport_Homo sapiens_hsa03013	2.51369213
4	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.49550221
5	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.45214827
6	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.32773083
7	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.32079705
8	Steroid biosynthesis_Homo sapiens_hsa00100	2.15989498
9	Glutathione metabolism_Homo sapiens_hsa00480	2.12821845
10	Homologous recombination_Homo sapiens_hsa03440	2.11300164
11	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.07563155
12	Fanconi anemia pathway_Homo sapiens_hsa03460	1.98962299
13	Mismatch repair_Homo sapiens_hsa03430	1.96883495
14	Proteasome_Homo sapiens_hsa03050	1.95816496
15	Fat digestion and absorption_Homo sapiens_hsa04975	1.95392952
16	Fatty acid metabolism_Homo sapiens_hsa01212	1.95386196
17	Propanoate metabolism_Homo sapiens_hsa00640	1.86951411
18	RNA polymerase_Homo sapiens_hsa03020	1.85943750
19	Non-homologous end-joining_Homo sapiens_hsa03450	1.69423665
20	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.65192209
21	DNA replication_Homo sapiens_hsa03030	1.59079648
22	Olfactory transduction_Homo sapiens_hsa04740	1.57883046
23	Basal transcription factors_Homo sapiens_hsa03022	1.54621945
24	Protein export_Homo sapiens_hsa03060	1.52754410
25	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.48789482
26	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.41278933
27	Fatty acid degradation_Homo sapiens_hsa00071	1.41241100
28	Base excision repair_Homo sapiens_hsa03410	1.40498314
29	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.33696979
30	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.27528528
31	Chemical carcinogenesis_Homo sapiens_hsa05204	1.21455335
32	PPAR signaling pathway_Homo sapiens_hsa03320	1.19074637
33	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.17685607
34	RNA degradation_Homo sapiens_hsa03018	1.17443866
35	Peroxisome_Homo sapiens_hsa04146	1.15357478
36	Pyruvate metabolism_Homo sapiens_hsa00620	1.13344967
37	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.12053535
38	Nitrogen metabolism_Homo sapiens_hsa00910	1.07149699
39	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.06142666
40	Nucleotide excision repair_Homo sapiens_hsa03420	1.05972105
41	Fatty acid elongation_Homo sapiens_hsa00062	1.04795052
42	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.04616017
43	Spliceosome_Homo sapiens_hsa03040	1.01820803
44	mRNA surveillance pathway_Homo sapiens_hsa03015	1.01504187
45	One carbon pool by folate_Homo sapiens_hsa00670	0.97439487
46	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.97205622
47	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.96758709
48	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.92320168
49	Arginine and proline metabolism_Homo sapiens_hsa00330	0.92081851
50	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.90274925
51	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.87731390
52	Purine metabolism_Homo sapiens_hsa00230	0.85086115
53	Regulation of autophagy_Homo sapiens_hsa04140	0.81044288
54	Huntingtons disease_Homo sapiens_hsa05016	0.80069638
55	Caffeine metabolism_Homo sapiens_hsa00232	0.78695121
56	Phototransduction_Homo sapiens_hsa04744	0.76729187
57	Tryptophan metabolism_Homo sapiens_hsa00380	0.75360430
58	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.75228179
59	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.75119718
60	Carbon metabolism_Homo sapiens_hsa01200	0.72101116
61	Taste transduction_Homo sapiens_hsa04742	0.71201259
62	Cell cycle_Homo sapiens_hsa04110	0.68950820
63	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.67349967
64	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.65464179
65	Pyrimidine metabolism_Homo sapiens_hsa00240	0.64449134
66	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.62212077
67	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.61792889
68	Metabolic pathways_Homo sapiens_hsa01100	0.61054823
69	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.57810077
70	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.56228578
71	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.56186548
72	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.54306796
73	Arginine biosynthesis_Homo sapiens_hsa00220	0.53812861
74	Retinol metabolism_Homo sapiens_hsa00830	0.50714817
75	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.47843031
76	Parkinsons disease_Homo sapiens_hsa05012	0.44834112
77	beta-Alanine metabolism_Homo sapiens_hsa00410	0.44209534
78	Oocyte meiosis_Homo sapiens_hsa04114	0.43861432
79	Lysine degradation_Homo sapiens_hsa00310	0.42190707
80	Oxidative phosphorylation_Homo sapiens_hsa00190	0.40477565
81	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.36246906
82	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.35583964
83	Circadian rhythm_Homo sapiens_hsa04710	0.35062085
84	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.34469393
85	ABC transporters_Homo sapiens_hsa02010	0.33349031
86	Selenocompound metabolism_Homo sapiens_hsa00450	0.31756475
87	Glycerolipid metabolism_Homo sapiens_hsa00561	0.31727786
88	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.31020107
89	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.30864202
90	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.29740800
91	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.28534932
92	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.28339061
93	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.28185391
94	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.27254237
95	Legionellosis_Homo sapiens_hsa05134	0.26444523
96	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.26236578
97	Linoleic acid metabolism_Homo sapiens_hsa00591	0.25517028
98	Nicotine addiction_Homo sapiens_hsa05033	0.24344140
99	Calcium signaling pathway_Homo sapiens_hsa04020	0.21914311
100	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.21474911

BRCC3P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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