BRD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schizophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.36774833
2nuclear pore organization (GO:0006999)4.76362892
3negative regulation of erythrocyte differentiation (GO:0045647)4.72747976
4regulation of NFAT protein import into nucleus (GO:0051532)4.40253992
5pore complex assembly (GO:0046931)4.19578517
6mitotic sister chromatid cohesion (GO:0007064)4.05028696
7response to muramyl dipeptide (GO:0032495)4.01265481
8regulation of RNA export from nucleus (GO:0046831)3.95904077
9positive regulation of gamma-delta T cell activation (GO:0046645)3.80471564
10negative regulation of histone methylation (GO:0031061)3.78055074
11protein localization to kinetochore (GO:0034501)3.73811413
12mitotic chromosome condensation (GO:0007076)3.51212390
13negative regulation of cell killing (GO:0031342)3.46215070
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.46215070
15regulation of histone H3-K9 methylation (GO:0051570)3.44971196
16cytoplasmic mRNA processing body assembly (GO:0033962)3.42194783
17histone H3-K36 demethylation (GO:0070544)3.41211214
18monoubiquitinated protein deubiquitination (GO:0035520)3.39724423
19dosage compensation (GO:0007549)3.35343614
20regulation of sister chromatid cohesion (GO:0007063)3.35163971
21thymic T cell selection (GO:0045061)3.34732438
22histone H2A monoubiquitination (GO:0035518)3.33829240
23mitotic nuclear envelope disassembly (GO:0007077)3.33562317
24positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.32471555
25positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.32471555
26positive regulation of mitotic sister chromatid separation (GO:1901970)3.32471555
27protein localization to chromosome, centromeric region (GO:0071459)3.29530867
28pre-miRNA processing (GO:0031054)3.23573588
29sister chromatid segregation (GO:0000819)3.21965120
30response to laminar fluid shear stress (GO:0034616)3.21262224
31regulation of gamma-delta T cell activation (GO:0046643)3.20020202
32histone lysine demethylation (GO:0070076)3.19915849
33histone demethylation (GO:0016577)3.17683473
34membrane disassembly (GO:0030397)3.15966017
35nuclear envelope disassembly (GO:0051081)3.15966017
36positive T cell selection (GO:0043368)3.12926180
37regulation of nucleobase-containing compound transport (GO:0032239)3.11510461
38regulation of histone H3-K27 methylation (GO:0061085)3.11450033
39negative thymic T cell selection (GO:0045060)3.11072811
40negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.09383143
41positive regulation of chromosome segregation (GO:0051984)3.08937441
42regulation of gamma-delta T cell differentiation (GO:0045586)3.07879834
43histone H3-K9 demethylation (GO:0033169)3.05098708
44RNA stabilization (GO:0043489)3.04007955
45mRNA stabilization (GO:0048255)3.04007955
46positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.01826834
47T cell selection (GO:0045058)3.01388245
48mitotic sister chromatid segregation (GO:0000070)2.96645336
49histone H3-K4 methylation (GO:0051568)2.95587145
50mannose metabolic process (GO:0006013)2.94841515
51negative T cell selection (GO:0043383)2.92288930
52regulation of spindle organization (GO:0090224)2.91718936
533-UTR-mediated mRNA stabilization (GO:0070935)2.88899844
54regulation of hippo signaling (GO:0035330)2.86009865
55positive regulation by symbiont of host defense response (GO:0052509)2.85864551
56modulation by symbiont of host defense response (GO:0052031)2.85864551
57modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.85864551
58modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.85864551
59positive regulation by organism of defense response of other organism involved in symbiotic interact2.85864551
60modulation by symbiont of host immune response (GO:0052553)2.85864551
61protein dealkylation (GO:0008214)2.85034190
62protein demethylation (GO:0006482)2.85034190
63glucocorticoid receptor signaling pathway (GO:0042921)2.84039337
64regulation of ARF protein signal transduction (GO:0032012)2.83838489
65DNA duplex unwinding (GO:0032508)2.83132886
66DNA geometric change (GO:0032392)2.81811121
67regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.80479733
68chromatin assembly (GO:0031497)2.78907009
69histone H3-K9 methylation (GO:0051567)2.76211719
70heterochromatin organization (GO:0070828)2.76025481
71mitotic metaphase plate congression (GO:0007080)2.75856319
72corticosteroid receptor signaling pathway (GO:0031958)2.75619771
73tolerance induction (GO:0002507)2.70488328
74histone mRNA catabolic process (GO:0071044)2.69832860
75regulation of DNA endoreduplication (GO:0032875)2.67488438
76metaphase plate congression (GO:0051310)2.67480272
77positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.66932957
78NLS-bearing protein import into nucleus (GO:0006607)2.66631921
79regulation of chromatin binding (GO:0035561)2.65965411
80gene silencing by RNA (GO:0031047)2.63780929
81meiotic chromosome segregation (GO:0045132)2.61786840
82sister chromatid cohesion (GO:0007062)2.60718703
83regulation of mitotic spindle organization (GO:0060236)2.60576527
84negative regulation of histone modification (GO:0031057)2.60295585
85kinetochore organization (GO:0051383)2.59222025
86histone H3-K4 trimethylation (GO:0080182)2.58832218
87protein localization to chromosome (GO:0034502)2.58580107
88trophectodermal cell differentiation (GO:0001829)2.58564786
89nuclear envelope organization (GO:0006998)2.58350920
90nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.58215762
91leukocyte aggregation (GO:0070486)2.58168866
92peptidyl-lysine trimethylation (GO:0018023)2.55638935
93adherens junction assembly (GO:0034333)2.54600734
94DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.54040745
95regulation of telomere maintenance via telomerase (GO:0032210)2.52532181
96histone H4-K12 acetylation (GO:0043983)2.52151878
97regulation of histone methylation (GO:0031060)2.51922916
98regulation of protein polyubiquitination (GO:1902914)2.51287130
99modulation by symbiont of host cellular process (GO:0044068)2.51118710
100negative regulation of chromatin modification (GO:1903309)2.50786868
101antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.50761258
102intracellular estrogen receptor signaling pathway (GO:0030520)2.50343310
103positive thymic T cell selection (GO:0045059)2.49642129
104apoptotic process involved in morphogenesis (GO:0060561)2.49501180
105signal complex assembly (GO:0007172)2.49290379
106positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.49123131
107response to UV-C (GO:0010225)2.48935712
108negative regulation of DNA repair (GO:0045738)2.48880038
109histone H3-K9 modification (GO:0061647)2.48599932
110histone monoubiquitination (GO:0010390)2.48420027
111gene silencing (GO:0016458)2.47965290
112macrophage activation involved in immune response (GO:0002281)2.47225056
113germinal center formation (GO:0002467)2.46262355
114histone lysine methylation (GO:0034968)2.45838454
115positive regulation of gene expression, epigenetic (GO:0045815)2.44861712
116regulation of mRNA stability (GO:0043488)2.44269104
117detection of other organism (GO:0098543)2.44183742
118regulation of T-helper 2 cell differentiation (GO:0045628)2.44059328
119cellular extravasation (GO:0045123)2.43084124
120negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.42732440
121cell-substrate adherens junction assembly (GO:0007045)2.42061045
122focal adhesion assembly (GO:0048041)2.42061045
123negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.42022678
124antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.42014608
125positive regulation of histone deacetylation (GO:0031065)2.41688909
126B cell receptor signaling pathway (GO:0050853)2.41586449
127activation of JUN kinase activity (GO:0007257)2.41531937
128histone H4 deacetylation (GO:0070933)2.41355203
129negative regulation of glial cell proliferation (GO:0060253)2.41220681
130modulation by virus of host process (GO:0019054)2.40878465
131detection of bacterium (GO:0016045)2.40430278
132mRNA transport (GO:0051028)2.40113995
133regulation of ARF GTPase activity (GO:0032312)2.39851638
134embryonic process involved in female pregnancy (GO:0060136)2.39168266
135DNA conformation change (GO:0071103)2.38720365
136establishment of chromosome localization (GO:0051303)2.38714168
137chromatin assembly or disassembly (GO:0006333)2.38626848
138response to peptidoglycan (GO:0032494)2.38154455
139regulation of chromatin silencing (GO:0031935)2.37737687
140negative regulation of toll-like receptor signaling pathway (GO:0034122)2.37702307
141negative regulation of DNA-dependent DNA replication (GO:2000104)2.37257283
142inner cell mass cell proliferation (GO:0001833)2.37143014
143T cell migration (GO:0072678)2.36518069
144negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.36313489
145epithelial cell differentiation involved in prostate gland development (GO:0060742)2.34651348
146DNA topological change (GO:0006265)2.34408753
147positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.33658048
148regulation of lipid kinase activity (GO:0043550)2.33645929
149planar cell polarity pathway involved in neural tube closure (GO:0090179)2.33309787
150negative regulation of T cell mediated immunity (GO:0002710)2.32292442
151regulation of RNA stability (GO:0043487)2.32104244
152DNA damage response, signal transduction resulting in transcription (GO:0042772)2.31842322
153protein localization to endosome (GO:0036010)2.31681112
154positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.31238975
155protein K6-linked ubiquitination (GO:0085020)2.31073707
156NIK/NF-kappaB signaling (GO:0038061)2.31033915
157histone H4-K16 acetylation (GO:0043984)2.30949082
158negative regulation of translation, ncRNA-mediated (GO:0040033)2.30540838
159regulation of translation, ncRNA-mediated (GO:0045974)2.30540838
160negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.30540838
161hepatocyte apoptotic process (GO:0097284)2.29317745
162histone H2A ubiquitination (GO:0033522)2.29301911
163chromosome segregation (GO:0007059)2.28923817
164regulation of gene silencing (GO:0060968)2.28182510
165positive regulation of Rap GTPase activity (GO:0032854)2.26968550
166negative regulation of myotube differentiation (GO:0010832)2.26789677
167positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.25575482
168antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.25399203
169negative regulation of granulocyte differentiation (GO:0030853)2.24596373
170regulation of phosphatidylinositol 3-kinase activity (GO:0043551)2.24475010
171antigen processing and presentation of endogenous antigen (GO:0019883)2.24002465
172regulation of type I interferon-mediated signaling pathway (GO:0060338)2.23097706
173stress fiber assembly (GO:0043149)2.22939606
174negative regulation of interleukin-12 production (GO:0032695)2.22298779
175activation of MAPKKK activity (GO:0000185)2.22287432
176regulation of necroptotic process (GO:0060544)2.19875691
177negative regulation of fatty acid transport (GO:2000192)2.19549312
178histone H3 deacetylation (GO:0070932)2.19251724
179atrioventricular valve morphogenesis (GO:0003181)2.18839061
180positive regulation of Cdc42 GTPase activity (GO:0043089)2.18384221
181regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.17876752

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.04195031
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.67484788
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.60992583
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.24123614
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.20458559
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.04438694
7MYC_22102868_ChIP-Seq_BL_Human2.96679876
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.81461079
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.72882213
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.57791740
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.45270606
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.36723631
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.33377070
14VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.31472439
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.29648610
16* KDM2B_26808549_Chip-Seq_K562_Human2.26694447
17LXR_22292898_ChIP-Seq_THP-1_Human2.14080122
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.11916966
19TCF7_22412390_ChIP-Seq_EML_Mouse2.09877857
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.06986405
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.02194518
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.95079052
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94063836
24AR_21909140_ChIP-Seq_LNCAP_Human1.91505559
25* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.78400603
26VDR_21846776_ChIP-Seq_THP-1_Human1.75226940
27ZFP281_18757296_ChIP-ChIP_E14_Mouse1.70099368
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.69391685
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.65929002
30RACK7_27058665_Chip-Seq_MCF-7_Human1.65839437
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.64869700
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.63833157
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.63318279
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.62961012
35MAF_26560356_Chip-Seq_TH2_Human1.61607966
36* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.58122425
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57980703
38PKCTHETA_26484144_Chip-Seq_BREAST_Human1.55718980
39* KDM2B_26808549_Chip-Seq_DND41_Human1.54848435
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52864395
41* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51063469
42EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.49285719
43* MYB_26560356_Chip-Seq_TH1_Human1.47907655
44GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.47258634
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.45152020
46SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.44397603
47FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.43362796
48UTX_26944678_Chip-Seq_JUKART_Human1.43020911
49EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.42373658
50HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41009405
51* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40156675
52MYB_26560356_Chip-Seq_TH2_Human1.38118532
53SCL_19346495_ChIP-Seq_HPC-7_Human1.37582551
54MAF_26560356_Chip-Seq_TH1_Human1.34916084
55* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32351228
56BP1_19119308_ChIP-ChIP_Hs578T_Human1.30838128
57ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.30412160
58CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27896925
59NFIB_24661679_ChIP-Seq_LUNG_Mouse1.27678985
60* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.26041051
61CIITA_25753668_ChIP-Seq_RAJI_Human1.26014944
62KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.25925103
63KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.25925103
64KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.25925103
65* CREB1_26743006_Chip-Seq_LNCaP_Human1.24173921
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.22814217
67MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22457554
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22079028
69KDM5A_27292631_Chip-Seq_BREAST_Human1.21251262
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20226075
71SMC4_20622854_ChIP-Seq_HELA_Human1.19699570
72* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19601711
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17969948
74RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17181668
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.15966936
76ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14646423
77RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14423053
78GATA1_19941826_ChIP-Seq_K562_Human1.14315640
79IRF8_27001747_Chip-Seq_BMDM_Mouse1.12856730
80NCOR1_26117541_ChIP-Seq_K562_Human1.11302591
81CLOCK_20551151_ChIP-Seq_293T_Human1.10941086
82* SA1_27219007_Chip-Seq_ERYTHROID_Human1.10892670
83* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10433385
84* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09653003
85CHD1_26751641_Chip-Seq_LNCaP_Human1.08971764
86FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.08029693
87* KDM2B_26808549_Chip-Seq_JURKAT_Human1.07849385
88* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07042599
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06817136
90FOXO3_23340844_ChIP-Seq_DLD1_Human1.06558837
91TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06288940
92P68_20966046_ChIP-Seq_HELA_Human1.05843653
93NANOG_21062744_ChIP-ChIP_HESCs_Human1.05802832
94RUNX_20019798_ChIP-Seq_JUKART_Human1.05641640
95MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05456937
96RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04483322
97NELFA_20434984_ChIP-Seq_ESCs_Mouse1.04163690
98VDR_24763502_ChIP-Seq_THP-1_Human1.03878061
99GATA6_25053715_ChIP-Seq_YYC3_Human1.03540034
100SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03050875
101ERG_21242973_ChIP-ChIP_JURKAT_Human1.02423822
102SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00523519
103SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00523519
104STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00164339
105TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99864433
106MYC_19079543_ChIP-ChIP_MESCs_Mouse0.99570112
107* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99231630
108CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99112878
109TCF3_18692474_ChIP-Seq_MESCs_Mouse0.98970124
110RUNX1_22412390_ChIP-Seq_EML_Mouse0.98781341
111MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.98716659
112* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98714139
113IRF8_22096565_ChIP-ChIP_GC-B_Human0.98607786
114BRD4_25478319_ChIP-Seq_HGPS_Human0.98047162
115SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97895929
116HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97705260
117NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.97142748
118GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96388402
119P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95995334
120PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95818601
121DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95654017
122NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95028449
123DROSHA_22980978_ChIP-Seq_HELA_Human0.94316872
124* UBF1/2_26484160_Chip-Seq_HMECs_Human0.92821379
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92777678
126RUNX1_27514584_Chip-Seq_MCF-7_Human0.91574582
127ELK3_25401928_ChIP-Seq_HUVEC_Human0.90264235
128TFEB_21752829_ChIP-Seq_HELA_Human0.90069325
129* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89599676
130* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89116289
131PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87944765
132ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87731189
133MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.87333588
134FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.86968425
135SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86892299
136SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85994967
137VDR_24787735_ChIP-Seq_THP-1_Human0.84709946
138SPI1_23127762_ChIP-Seq_K562_Human0.84708248
139PU_27001747_Chip-Seq_BMDM_Mouse0.84025160
140SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83672291
141YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.83393842
142SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82658220
143ATF3_27146783_Chip-Seq_COLON_Human0.81936293
144ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.81778570
145TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.79320690
146ESR1_21235772_ChIP-Seq_MCF-7_Human0.79056927
147GATA3_27048872_Chip-Seq_THYMUS_Human0.78982843

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005076_abnormal_cell_differentiation3.03304955
2MP0008057_abnormal_DNA_replication2.89738721
3MP0003436_decreased_susceptibility_to2.80955984
4MP0010352_gastrointestinal_tract_polyps2.74099797
5MP0005409_darkened_coat_color2.65031043
6MP0010094_abnormal_chromosome_stability2.65022437
7MP0003111_abnormal_nucleus_morphology2.61639298
8MP0000569_abnormal_digit_pigmentation2.59616142
9MP0003693_abnormal_embryo_hatching2.46980926
10MP0003077_abnormal_cell_cycle2.41103248
11MP0005451_abnormal_body_composition2.21454008
12MP0003705_abnormal_hypodermis_morpholog2.20879965
13MP0010307_abnormal_tumor_latency2.20796645
14MP0002396_abnormal_hematopoietic_system2.18639483
15MP0002877_abnormal_melanocyte_morpholog2.09636411
16MP0008007_abnormal_cellular_replicative1.99232769
17MP0004381_abnormal_hair_follicle1.97715849
18MP0009278_abnormal_bone_marrow1.95878042
19MP0005666_abnormal_adipose_tissue1.84550095
20MP0004957_abnormal_blastocyst_morpholog1.84113950
21MP0004808_abnormal_hematopoietic_stem1.80450045
22MP0000350_abnormal_cell_proliferation1.77504390
23MP0008260_abnormal_autophagy1.74549283
24MP0008877_abnormal_DNA_methylation1.67597982
25MP0003566_abnormal_cell_adhesion1.57333398
26MP0005380_embryogenesis_phenotype1.56604012
27MP0001672_abnormal_embryogenesis/_devel1.56604012
28MP0003828_pulmonary_edema1.55415754
29MP0004510_myositis1.54210846
30MP0002086_abnormal_extraembryonic_tissu1.53179336
31MP0001730_embryonic_growth_arrest1.52922573
32MP0001851_eye_inflammation1.51271836
33MP0010234_abnormal_vibrissa_follicle1.50734099
34MP0003172_abnormal_lysosome_physiology1.50372591
35MP0003984_embryonic_growth_retardation1.49156958
36MP0002009_preneoplasia1.48828523
37MP0003121_genomic_imprinting1.48739155
38MP0004264_abnormal_extraembryonic_tissu1.48403403
39MP0003763_abnormal_thymus_physiology1.48239500
40MP0002088_abnormal_embryonic_growth/wei1.47187970
41MP0003787_abnormal_imprinting1.46112861
42MP0002998_abnormal_bone_remodeling1.45747233
43MP0002084_abnormal_developmental_patter1.45731290
44MP0004197_abnormal_fetal_growth/weight/1.44965417
45MP0003300_gastrointestinal_ulcer1.42149420
46MP0008058_abnormal_DNA_repair1.41115134
47MP0005000_abnormal_immune_tolerance1.40676247
48MP0009333_abnormal_splenocyte_physiolog1.38628281
49MP0005375_adipose_tissue_phenotype1.37819602
50MP0002166_altered_tumor_susceptibility1.37538818
51MP0001790_abnormal_immune_system1.37375274
52MP0005387_immune_system_phenotype1.37375274
53MP0002419_abnormal_innate_immunity1.36701456
54MP0000685_abnormal_immune_system1.35455539
55MP0002085_abnormal_embryonic_tissue1.35172940
56MP0005025_abnormal_response_to1.34372436
57MP0002420_abnormal_adaptive_immunity1.34232284
58MP0000733_abnormal_muscle_development1.34076469
59MP0001545_abnormal_hematopoietic_system1.32961203
60MP0005397_hematopoietic_system_phenotyp1.32961203
61MP0001819_abnormal_immune_cell1.32318691
62MP0002796_impaired_skin_barrier1.28170798
63MP0002723_abnormal_immune_serum1.28150552
64MP0002405_respiratory_system_inflammati1.27558157
65MP0001697_abnormal_embryo_size1.27091397
66MP0001849_ear_inflammation1.22950642
67MP0005058_abnormal_lysosome_morphology1.22896937
68MP0004185_abnormal_adipocyte_glucose1.21555643
69MP0000383_abnormal_hair_follicle1.20209829
70MP0000716_abnormal_immune_system1.19552549
71MP0003890_abnormal_embryonic-extraembry1.19412985
72MP0003941_abnormal_skin_development1.17418568
73MP0002006_tumorigenesis1.16716449
74MP0000703_abnormal_thymus_morphology1.14227908
75MP0001873_stomach_inflammation1.12793498
76MP0003183_abnormal_peptide_metabolism1.12072400
77MP0010678_abnormal_skin_adnexa1.11880920
78MP0003123_paternal_imprinting1.11851412
79MP0000490_abnormal_crypts_of1.10992649
80MP0008961_abnormal_basal_metabolism1.10367708
81MP0001915_intracranial_hemorrhage1.08192989
82MP0010155_abnormal_intestine_physiology1.08019285
83MP0002089_abnormal_postnatal_growth/wei1.06224930
84MP0002398_abnormal_bone_marrow1.05791856
85MP0002060_abnormal_skin_morphology1.05327349
86MP0001348_abnormal_lacrimal_gland1.04712850
87MP0000537_abnormal_urethra_morphology1.04109503
88MP0002925_abnormal_cardiovascular_devel1.03971185
89MP0002080_prenatal_lethality1.03189235
90MP0004130_abnormal_muscle_cell1.03139681
91MP0003786_premature_aging1.03121156
92MP0008995_early_reproductive_senescence1.02784340
93MP0003453_abnormal_keratinocyte_physiol1.02597796
94MP0009703_decreased_birth_body1.00958304
95MP0005310_abnormal_salivary_gland1.00473221
96MP0003279_aneurysm0.99905337
97MP0004947_skin_inflammation0.99616859
98MP0002019_abnormal_tumor_incidence0.99268988
99MP0003567_abnormal_fetal_cardiomyocyte0.98911440
100MP0003724_increased_susceptibility_to0.98731657
101MP0000432_abnormal_head_morphology0.98493553
102MP0005023_abnormal_wound_healing0.98369581
103MP0005174_abnormal_tail_pigmentation0.98253210
104MP0003935_abnormal_craniofacial_develop0.98022125
105MP0003091_abnormal_cell_migration0.97493791
106MP0010630_abnormal_cardiac_muscle0.97481950
107MP0005671_abnormal_response_to0.96843034
108MP0002429_abnormal_blood_cell0.95273590
109MP0001835_abnormal_antigen_presentation0.94189523
110MP0006054_spinal_hemorrhage0.93926935
111MP0003937_abnormal_limbs/digits/tail_de0.93032643
112MP0009115_abnormal_fat_cell0.92730985
113MP0001533_abnormal_skeleton_physiology0.92662290
114MP0003115_abnormal_respiratory_system0.92265840
115MP0000371_diluted_coat_color0.91942769
116MP0009840_abnormal_foam_cell0.90837516
117MP0001800_abnormal_humoral_immune0.90668345
118MP0000428_abnormal_craniofacial_morphol0.90600288
119MP0002249_abnormal_larynx_morphology0.89905095
120MP0001293_anophthalmia0.89897467
121MP0004858_abnormal_nervous_system0.87465631
122MP0000313_abnormal_cell_death0.87325716
123MP0002092_abnormal_eye_morphology0.86764969
124MP0003448_altered_tumor_morphology0.86469872
125MP0000566_synostosis0.86087749
126MP0010030_abnormal_orbit_morphology0.84326789
127MP0009672_abnormal_birth_weight0.84029744
128MP0001216_abnormal_epidermal_layer0.83865409
129MP0005621_abnormal_cell_physiology0.83440953
130MP0002722_abnormal_immune_system0.82544571
131MP0000767_abnormal_smooth_muscle0.82279025
132MP0002254_reproductive_system_inflammat0.81457109
133MP0003221_abnormal_cardiomyocyte_apopto0.81190238
134MP0003303_peritoneal_inflammation0.81107580
135MP0002697_abnormal_eye_size0.80844943
136MP0009053_abnormal_anal_canal0.79778066
137MP0009931_abnormal_skin_appearance0.79743216
138MP0005367_renal/urinary_system_phenotyp0.78906765
139MP0000516_abnormal_urinary_system0.78906765
140MP0003755_abnormal_palate_morphology0.78542047
141MP0003045_fibrosis0.78099188
142MP0002138_abnormal_hepatobiliary_system0.76600177
143MP0000858_altered_metastatic_potential0.76285371
144MP0001784_abnormal_fluid_regulation0.75983075
145MP0005248_abnormal_Harderian_gland0.74991156
146MP0000689_abnormal_spleen_morphology0.74893738
147MP0004233_abnormal_muscle_weight0.74607763
148MP0002452_abnormal_antigen_presenting0.74351587
149MP0005257_abnormal_intraocular_pressure0.73903378
150MP0008932_abnormal_embryonic_tissue0.73708502
151MP0002933_joint_inflammation0.69304357
152MP0001853_heart_inflammation0.68952735
153MP0003866_abnormal_defecation0.67519541
154MP0006138_congestive_heart_failure0.67376700

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.08687381
2Obstructive sleep apnea (HP:0002870)3.53083673
3Eczematoid dermatitis (HP:0000976)3.49965974
4Lip pit (HP:0100267)3.04240211
5Volvulus (HP:0002580)2.89211635
6Broad face (HP:0000283)2.86736218
7Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.79418937
8Chromsome breakage (HP:0040012)2.75069976
9Chromosomal breakage induced by crosslinking agents (HP:0003221)2.70817698
10Long eyelashes (HP:0000527)2.64956323
11Short 4th metacarpal (HP:0010044)2.59999183
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.59999183
13Increased IgE level (HP:0003212)2.49293602
14Ectopic kidney (HP:0000086)2.39249121
15Deep palmar crease (HP:0006191)2.38034049
16Germ cell neoplasia (HP:0100728)2.30970609
17Neonatal hypoglycemia (HP:0001998)2.28871291
18Prominent nose (HP:0000448)2.26223107
19Cerebral aneurysm (HP:0004944)2.24566645
20Abnormality of the radial head (HP:0003995)2.22736930
21Subacute progressive viral hepatitis (HP:0006572)2.22192830
22Spontaneous hematomas (HP:0007420)2.20447456
23Disproportionate tall stature (HP:0001519)2.18482186
24Abnormality of the thoracic spine (HP:0100711)2.17869086
25Cellulitis (HP:0100658)2.17042937
26Thoracic kyphosis (HP:0002942)2.16626011
27Urethral obstruction (HP:0000796)2.14412064
28Abnormality of chromosome stability (HP:0003220)2.11128857
29Increased nuchal translucency (HP:0010880)2.10939962
30Ependymoma (HP:0002888)2.09825133
31Sandal gap (HP:0001852)2.09214459
32Papillary thyroid carcinoma (HP:0002895)2.09090382
33Thin bony cortex (HP:0002753)2.08034155
34Flat acetabular roof (HP:0003180)2.05614853
35Malignant gastrointestinal tract tumors (HP:0006749)2.04968832
36Gastrointestinal carcinoma (HP:0002672)2.04968832
37Recurrent bacterial skin infections (HP:0005406)2.04631527
38Ulnar bowing (HP:0003031)2.04240168
39Heterotopia (HP:0002282)2.04015070
40Facial hemangioma (HP:0000329)2.02906137
41Dysmetric saccades (HP:0000641)2.01879757
42Mitral valve prolapse (HP:0001634)2.01003704
43Long palpebral fissure (HP:0000637)1.98728366
44Colitis (HP:0002583)1.97978603
45Acute myeloid leukemia (HP:0004808)1.96054625
46Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.95789421
47Neoplasm of the oral cavity (HP:0100649)1.94937546
48Deviation of the thumb (HP:0009603)1.94920229
49Distal lower limb amyotrophy (HP:0008944)1.94588553
50Broad thumb (HP:0011304)1.93632835
51Medulloblastoma (HP:0002885)1.92981049
52Abnormality of the nasal septum (HP:0000419)1.92800006
53Gingivitis (HP:0000230)1.92020301
54Hyperacusis (HP:0010780)1.90525343
55Recurrent abscess formation (HP:0002722)1.89903078
56Absent frontal sinuses (HP:0002688)1.88089400
57Mediastinal lymphadenopathy (HP:0100721)1.85837397
58Cerebral inclusion bodies (HP:0100314)1.85835198
59Aplasia/Hypoplasia of the uvula (HP:0010293)1.85625171
60Syringomyelia (HP:0003396)1.84864257
61Spinal cord lesions (HP:0100561)1.84864257
62Abnormality of the columella (HP:0009929)1.84245857
63Slow saccadic eye movements (HP:0000514)1.83538641
64Shallow orbits (HP:0000586)1.82680330
65Abnormality of the carotid arteries (HP:0005344)1.82379600
66Selective tooth agenesis (HP:0001592)1.82064373
67Abnormality of the astrocytes (HP:0100707)1.81538043
68Astrocytoma (HP:0009592)1.81538043
69Skull defect (HP:0001362)1.81534563
70Myelodysplasia (HP:0002863)1.80042651
71Deep philtrum (HP:0002002)1.79911632
72Abnormality of the labia minora (HP:0012880)1.79887820
73Genu recurvatum (HP:0002816)1.79711076
74Gastrointestinal infarctions (HP:0005244)1.79025029
75Persistence of primary teeth (HP:0006335)1.78760645
76Segmental peripheral demyelination/remyelination (HP:0003481)1.78238531
77Proximal placement of thumb (HP:0009623)1.77396240
78Patellar aplasia (HP:0006443)1.77200509
79Sparse lateral eyebrow (HP:0005338)1.76691179
80Narrow palate (HP:0000189)1.76633181
81Transitional cell carcinoma of the bladder (HP:0006740)1.76027203
82Leiomyosarcoma (HP:0100243)1.74406230
83Uterine leiomyosarcoma (HP:0002891)1.74406230
84Shawl scrotum (HP:0000049)1.73869317
85Turricephaly (HP:0000262)1.73059081
86Biliary tract neoplasm (HP:0100574)1.72933773
87Mitral regurgitation (HP:0001653)1.72381955
88Truncal obesity (HP:0001956)1.72291435
89Milia (HP:0001056)1.72268763
90Trigonocephaly (HP:0000243)1.71317599
91Anal stenosis (HP:0002025)1.70958423
92Gastrointestinal inflammation (HP:0004386)1.70918536
93Meckel diverticulum (HP:0002245)1.70637216
94Overgrowth (HP:0001548)1.70299036
95Missing ribs (HP:0000921)1.70149764
96Supernumerary ribs (HP:0005815)1.69094120
97Arnold-Chiari malformation (HP:0002308)1.68995158
98Abnormality of the 4th metacarpal (HP:0010012)1.68757108
99Sparse scalp hair (HP:0002209)1.67711524
100Onion bulb formation (HP:0003383)1.67649868
101High pitched voice (HP:0001620)1.66914325
102Spinal muscular atrophy (HP:0007269)1.66502492
103Depressed nasal tip (HP:0000437)1.66402762
104Clubbing of toes (HP:0100760)1.66090915
105Bicuspid aortic valve (HP:0001647)1.65911732
106Hypoplastic labia majora (HP:0000059)1.65676230
107Lower limb asymmetry (HP:0100559)1.65136455
108Abnormality of chromosome segregation (HP:0002916)1.65064967
109Abnormality of the humeroradial joint (HP:0100744)1.65021456
110Cafe-au-lait spot (HP:0000957)1.64202842
111Recurrent viral infections (HP:0004429)1.63842568
112Abnormality of the distal phalanx of the thumb (HP:0009617)1.63731878
113Abnormality of the preputium (HP:0100587)1.62749256
114Bladder carcinoma (HP:0002862)1.62218092
115Bladder neoplasm (HP:0009725)1.62218092
116Broad phalanges of the hand (HP:0009768)1.61982897
117Low anterior hairline (HP:0000294)1.61963907
118Abnormality of the ileum (HP:0001549)1.61793503
119Aplasia/Hypoplasia of the patella (HP:0006498)1.61718856
120Limited elbow extension (HP:0001377)1.61623650
121Dislocated radial head (HP:0003083)1.61592203
122Abnormality of the intervertebral disk (HP:0005108)1.61439679
123Rib fusion (HP:0000902)1.60762654
124Blepharitis (HP:0000498)1.60716158
125Pointed chin (HP:0000307)1.60026918
126Aneurysm (HP:0002617)1.59783800
127Cutis marmorata (HP:0000965)1.59435493
128Broad palm (HP:0001169)1.59173341
129Impulsivity (HP:0100710)1.58897883
130Hematochezia (HP:0002573)1.57888855
131Renovascular hypertension (HP:0100817)1.57333289
132Prostate neoplasm (HP:0100787)1.56819651
133Polygenic inheritance (HP:0010982)1.56710972
134Viral hepatitis (HP:0006562)1.56475446
135Metaphyseal cupping (HP:0003021)1.55673996
136Dilatation of the ascending aorta (HP:0005111)1.55620692
137Bowel incontinence (HP:0002607)1.55575277
138Glioma (HP:0009733)1.55318906
139Ankle contracture (HP:0006466)1.54858826
140Supernumerary nipples (HP:0002558)1.54614757
141Thickened helices (HP:0000391)1.54090810
142Macroorchidism (HP:0000053)1.53845487
143Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.53346149
144Increased connective tissue (HP:0009025)1.53283277
145Basal cell carcinoma (HP:0002671)1.53066121
146Abnormality of the lower motor neuron (HP:0002366)1.52949418
147Myositis (HP:0100614)1.52237568
148Thin ribs (HP:0000883)1.51841893
149Difficulty running (HP:0009046)1.51352453
150Hypercortisolism (HP:0001578)1.51001104
151Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.50751040
152Short 1st metacarpal (HP:0010034)1.50751040
153Renal duplication (HP:0000075)1.49863394
154Precocious puberty (HP:0000826)1.49848078
155Abnormality of the calcaneus (HP:0008364)1.49832395
156Abnormality of macrophages (HP:0004311)1.49617917
157Autoimmune thrombocytopenia (HP:0001973)1.49572794
158Aplasia/Hypoplasia of the sternum (HP:0006714)1.49468164
159Vertebral arch anomaly (HP:0008438)1.49416722
160Peripheral hypomyelination (HP:0007182)1.48520197
161Abnormality of the phalanges of the hallux (HP:0010057)1.46016611
162Abnormality of the aortic arch (HP:0012303)1.44291307
163Protrusio acetabuli (HP:0003179)1.43822341
164Recurrent fungal infections (HP:0002841)1.43793741
165Inflammation of the large intestine (HP:0002037)1.43648690
166Gastrointestinal stroma tumor (HP:0100723)1.42688662
167Visceral angiomatosis (HP:0100761)1.41186742
168Increased variability in muscle fiber diameter (HP:0003557)1.40553226
169Annular pancreas (HP:0001734)1.40451279
170Sporadic (HP:0003745)1.40420556
171Abnormality of the parietal bone (HP:0002696)1.40361136

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.03555974
2LATS14.01316077
3PRPF4B3.98737463
4CDC72.82680477
5MAP3K102.65253494
6EEF2K2.64253664
7SMG12.58428233
8STK32.49466274
9NEK22.24858553
10STK101.91671540
11BRD41.89498228
12FGFR41.86986740
13MAP3K131.84592784
14STK38L1.78078665
15MARK21.71087921
16MAP2K31.68830970
17CAMK1D1.60603028
18TTK1.59622741
19STK41.55504800
20RIPK41.53160917
21CDK61.41112410
22CDK41.38050350
23TRIB31.37507549
24PTK61.37128565
25ERN11.37125171
26PKN21.36022051
27RPS6KB21.34711206
28FGFR31.34478613
29MTOR1.32980621
30LATS21.31252790
31CHUK1.27618375
32MAP4K11.27132482
33PIM11.26631371
34EPHA21.22630664
35NUAK11.20368964
36SRPK11.18731985
37CAMK1G1.17986875
38CDK71.17512033
39ATR1.16273863
40CHEK11.15670397
41PDGFRB1.15343026
42CDK91.14164153
43JAK31.12269656
44ZAP701.10732298
45ALK1.10416458
46MAP3K111.10271910
47CDC42BPA1.08582348
48ATM1.07909940
49MAP3K11.07843983
50PDGFRA1.07040444
51DYRK1B1.06888734
52CHEK21.06783113
53TTN1.05989450
54MAP3K61.01740642
55BMX1.00829925
56RPS6KC10.99034945
57RPS6KL10.99034945
58RIPK10.98399791
59ICK0.98361903
60TAOK30.98305215
61MAP3K70.97538484
62TRPM70.95200194
63FRK0.93796670
64MELK0.92660844
65MAP3K140.91350785
66RPS6KA20.91142267
67IRAK30.89957785
68AURKB0.89368714
69MARK30.89059480
70BTK0.87805999
71KSR20.87772248
72DMPK0.86711125
73FES0.86036664
74RET0.84013091
75MAP3K30.83268573
76PLK10.81765275
77IKBKE0.81488714
78BRSK20.81332828
79IRAK40.81133501
80ITK0.81110081
81CDK20.80343947
82PAK40.79699136
83PLK40.79555826
84STK240.78540336
85RPS6KA60.78222361
86MKNK20.77431472
87CAMKK10.77319718
88PRKD20.77064535
89PASK0.75912881
90NLK0.74849635
91SIK30.73837849
92MAP3K80.71734035
93CLK10.71565386
94JAK10.70757490
95BLK0.69370308
96TSSK60.68510444
97MAPK150.68059541
98TYRO30.67438263
99PDPK10.67267144
100TNK20.67036885
101TBK10.66711587
102ZAK0.66522052
103RPS6KA40.65745517
104WEE10.65574536
105SGK30.65454138
106MAPK70.65424637
107AKT30.65266687
108ERBB30.65261767
109MAP3K90.63039251
110SGK20.62622131
111MKNK10.62582694
112MAPK120.62526529
113DDR20.62284258
114TAOK20.61660907
115FGR0.61641870
116PDK10.61194022
117LRRK20.61189941
118TYK20.60590239
119CSK0.60491627
120SIK20.60182384
121CDK10.59851048
122PLK30.59331677
123TGFBR10.58568973
124FGFR20.58562953
125MAPK140.57997916
126YES10.55603601
127ACVR1B0.54588160
128TAOK10.54546851
129STK110.54247118
130IRAK20.54111802
131RPS6KA10.53903660
132MAP2K20.53743665
133NTRK20.53293030
134LCK0.52920044
135TGFBR20.52808788
136SIK10.52160921
137JAK20.51872676
138EPHB10.50714178
139MAPK10.50707001
140CSNK1D0.50434283
141AKT10.49974803
142SGK2230.49878913
143SGK4940.49878913
144PAK20.49214204
145WNK10.47722257
146MAPK110.47086947
147GRK60.47022910
148EPHA30.45549698
149HCK0.43939741
150CSF1R0.43814049
151HIPK20.43722328
152PRKDC0.42836146
153MAPK100.41699808
154IKBKB0.41409530
155GSK3B0.40854534

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041101.90949301
2MicroRNAs in cancer_Homo sapiens_hsa052061.79907906
3mRNA surveillance pathway_Homo sapiens_hsa030151.76507650
4Small cell lung cancer_Homo sapiens_hsa052221.70065801
5Chronic myeloid leukemia_Homo sapiens_hsa052201.68801124
6VEGF signaling pathway_Homo sapiens_hsa043701.65270180
7Fanconi anemia pathway_Homo sapiens_hsa034601.64967979
8Adherens junction_Homo sapiens_hsa045201.63505614
9RNA transport_Homo sapiens_hsa030131.62768330
10Lysine degradation_Homo sapiens_hsa003101.57108258
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.51180348
12Non-homologous end-joining_Homo sapiens_hsa034501.48321564
13mTOR signaling pathway_Homo sapiens_hsa041501.44530778
14p53 signaling pathway_Homo sapiens_hsa041151.42098786
15Spliceosome_Homo sapiens_hsa030401.39347459
16Notch signaling pathway_Homo sapiens_hsa043301.38205730
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38084263
18Transcriptional misregulation in cancer_Homo sapiens_hsa052021.37939158
19Herpes simplex infection_Homo sapiens_hsa051681.37655461
20Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.35617260
21Viral carcinogenesis_Homo sapiens_hsa052031.31895257
22Primary immunodeficiency_Homo sapiens_hsa053401.31168912
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.30683908
24Pancreatic cancer_Homo sapiens_hsa052121.29070054
25Colorectal cancer_Homo sapiens_hsa052101.29033216
26Antigen processing and presentation_Homo sapiens_hsa046121.28973760
27Endometrial cancer_Homo sapiens_hsa052131.28670351
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.27375567
29HTLV-I infection_Homo sapiens_hsa051661.26314147
30Prostate cancer_Homo sapiens_hsa052151.26230102
31B cell receptor signaling pathway_Homo sapiens_hsa046621.23429528
32Other glycan degradation_Homo sapiens_hsa005111.22824790
33Non-small cell lung cancer_Homo sapiens_hsa052231.21590915
34Phospholipase D signaling pathway_Homo sapiens_hsa040721.19360004
35Mismatch repair_Homo sapiens_hsa034301.19304685
36Acute myeloid leukemia_Homo sapiens_hsa052211.18281228
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16934298
38DNA replication_Homo sapiens_hsa030301.14293739
39Hippo signaling pathway_Homo sapiens_hsa043901.14017977
40Thyroid hormone signaling pathway_Homo sapiens_hsa049191.13565469
41RNA degradation_Homo sapiens_hsa030181.13403459
42Basal cell carcinoma_Homo sapiens_hsa052171.12556731
43Viral myocarditis_Homo sapiens_hsa054161.12168667
44Toxoplasmosis_Homo sapiens_hsa051451.11759764
45GnRH signaling pathway_Homo sapiens_hsa049121.11384055
46Proteoglycans in cancer_Homo sapiens_hsa052051.10118261
47Measles_Homo sapiens_hsa051621.09489495
48Hepatitis B_Homo sapiens_hsa051611.09329421
49Homologous recombination_Homo sapiens_hsa034401.09123326
50Base excision repair_Homo sapiens_hsa034101.08788197
51TGF-beta signaling pathway_Homo sapiens_hsa043501.08159570
52T cell receptor signaling pathway_Homo sapiens_hsa046601.07945461
53Hepatitis C_Homo sapiens_hsa051601.07703246
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.06816046
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05450462
56FoxO signaling pathway_Homo sapiens_hsa040681.05421995
57Bladder cancer_Homo sapiens_hsa052191.04511008
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03267211
59Insulin signaling pathway_Homo sapiens_hsa049101.03052927
60Osteoclast differentiation_Homo sapiens_hsa043801.01904561
61Focal adhesion_Homo sapiens_hsa045101.01809011
62Dorso-ventral axis formation_Homo sapiens_hsa043200.99608692
63Influenza A_Homo sapiens_hsa051640.99519860
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99091906
65Thyroid cancer_Homo sapiens_hsa052160.97843928
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97752481
67Estrogen signaling pathway_Homo sapiens_hsa049150.96954791
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96156762
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95617336
70Apoptosis_Homo sapiens_hsa042100.95305652
71Prolactin signaling pathway_Homo sapiens_hsa049170.95241091
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.95133060
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.94867593
74MAPK signaling pathway_Homo sapiens_hsa040100.94667383
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93694277
76Basal transcription factors_Homo sapiens_hsa030220.92657486
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.91122688
78Pathways in cancer_Homo sapiens_hsa052000.90316355
79Epstein-Barr virus infection_Homo sapiens_hsa051690.89770077
80Tuberculosis_Homo sapiens_hsa051520.89618624
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.88597516
82TNF signaling pathway_Homo sapiens_hsa046680.87642479
83One carbon pool by folate_Homo sapiens_hsa006700.87099650
84ECM-receptor interaction_Homo sapiens_hsa045120.85271553
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.83431667
86Hematopoietic cell lineage_Homo sapiens_hsa046400.82866423
87Malaria_Homo sapiens_hsa051440.82248463
88Leishmaniasis_Homo sapiens_hsa051400.81840320
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.81568699
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81140228
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.81048088
92Long-term potentiation_Homo sapiens_hsa047200.80486308
93Insulin resistance_Homo sapiens_hsa049310.79925921
94Renal cell carcinoma_Homo sapiens_hsa052110.79823099
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78846309
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75687395
97Systemic lupus erythematosus_Homo sapiens_hsa053220.75632406
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74758691
99Platelet activation_Homo sapiens_hsa046110.73144537
100Glioma_Homo sapiens_hsa052140.72632508
101Wnt signaling pathway_Homo sapiens_hsa043100.72029472
102Prion diseases_Homo sapiens_hsa050200.69731650
103Chemokine signaling pathway_Homo sapiens_hsa040620.69725973
104AMPK signaling pathway_Homo sapiens_hsa041520.69039659
105Type II diabetes mellitus_Homo sapiens_hsa049300.68417656
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66760732
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.66505792
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66155126
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66151207
110Rap1 signaling pathway_Homo sapiens_hsa040150.65191245
111Inositol phosphate metabolism_Homo sapiens_hsa005620.64649725
112Amoebiasis_Homo sapiens_hsa051460.62394342
113Hedgehog signaling pathway_Homo sapiens_hsa043400.61870062
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60842994
115Endocytosis_Homo sapiens_hsa041440.60676519
116Legionellosis_Homo sapiens_hsa051340.60573712
117ErbB signaling pathway_Homo sapiens_hsa040120.60312648
118Choline metabolism in cancer_Homo sapiens_hsa052310.60022177
119Shigellosis_Homo sapiens_hsa051310.59698047
120HIF-1 signaling pathway_Homo sapiens_hsa040660.59404274
121Oocyte meiosis_Homo sapiens_hsa041140.59233279
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58396596
123Nucleotide excision repair_Homo sapiens_hsa034200.58343062
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58275933
125Melanoma_Homo sapiens_hsa052180.57815268
126Salmonella infection_Homo sapiens_hsa051320.57763714
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.57042029
128Ras signaling pathway_Homo sapiens_hsa040140.53769088
129Axon guidance_Homo sapiens_hsa043600.53364240
130Melanogenesis_Homo sapiens_hsa049160.51730036
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49004662

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »