BRD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.52058865
2regulation of histone H3-K27 methylation (GO:0061085)4.20779516
3nuclear pore complex assembly (GO:0051292)3.75147787
4cytoplasmic mRNA processing body assembly (GO:0033962)3.59903626
5pre-miRNA processing (GO:0031054)3.59307554
6RNA stabilization (GO:0043489)3.46149778
7mRNA stabilization (GO:0048255)3.46149778
8heterochromatin organization (GO:0070828)3.42946088
9regulation of RNA export from nucleus (GO:0046831)3.42741447
10positive regulation of histone deacetylation (GO:0031065)3.42740624
11nuclear pore organization (GO:0006999)3.33668040
12response to muramyl dipeptide (GO:0032495)3.21359021
13negative regulation of histone methylation (GO:0031061)3.19286768
14glucocorticoid receptor signaling pathway (GO:0042921)3.18986074
15mannose metabolic process (GO:0006013)3.16205112
16regulation of NFAT protein import into nucleus (GO:0051532)3.13420063
17mitotic chromosome condensation (GO:0007076)3.12827320
18negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.10978822
19histone H3-K4 trimethylation (GO:0080182)3.07359558
20positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.06254420
21regulation of hippo signaling (GO:0035330)3.05868622
22peptidyl-lysine dimethylation (GO:0018027)3.03422907
23positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.01918932
24regulation of nucleobase-containing compound transport (GO:0032239)2.95492475
25regulation of mammary gland epithelial cell proliferation (GO:0033599)2.94294659
26NLS-bearing protein import into nucleus (GO:0006607)2.93537536
27chromosome condensation (GO:0030261)2.91815272
28mitotic sister chromatid cohesion (GO:0007064)2.89953559
29positive thymic T cell selection (GO:0045059)2.89324095
30corticosteroid receptor signaling pathway (GO:0031958)2.86008028
31positive regulation of RNA splicing (GO:0033120)2.85079537
32pore complex assembly (GO:0046931)2.83788464
33intracellular estrogen receptor signaling pathway (GO:0030520)2.80419311
34negative regulation of viral release from host cell (GO:1902187)2.79919982
35CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.78701610
36positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.78217197
37regulation of interleukin-12 biosynthetic process (GO:0045075)2.77309742
38regulation of chromatin binding (GO:0035561)2.76479811
39lymph vessel development (GO:0001945)2.75831633
40activation of Rac GTPase activity (GO:0032863)2.74492325
41modulation by virus of host process (GO:0019054)2.74120316
42dosage compensation (GO:0007549)2.72485095
43positive regulation of SMAD protein import into nucleus (GO:0060391)2.69669352
44positive regulation by host of viral transcription (GO:0043923)2.68933661
45response to laminar fluid shear stress (GO:0034616)2.68473202
46histone H3-K36 demethylation (GO:0070544)2.68263473
47negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.66493068
48protein dealkylation (GO:0008214)2.64061187
49protein demethylation (GO:0006482)2.64061187
50germ cell migration (GO:0008354)2.63763756
51trophectodermal cell differentiation (GO:0001829)2.63225650
52regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.61214777
53DNA packaging (GO:0006323)2.60599523
54negative regulation of myotube differentiation (GO:0010832)2.60576485
55regulation of mRNA stability (GO:0043488)2.60476089
56modulation by symbiont of host cellular process (GO:0044068)2.60326528
57embryonic camera-type eye morphogenesis (GO:0048596)2.59997855
58hippo signaling (GO:0035329)2.59103570
59histone H2A monoubiquitination (GO:0035518)2.54814489
60chromatin assembly (GO:0031497)2.53631483
61apoptotic process involved in morphogenesis (GO:0060561)2.52656892
62gene silencing by RNA (GO:0031047)2.51302907
63atrioventricular valve morphogenesis (GO:0003181)2.50781962
64activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.50626114
65regulation of histone methylation (GO:0031060)2.49560167
66DNA unwinding involved in DNA replication (GO:0006268)2.49513324
67cellular response to epidermal growth factor stimulus (GO:0071364)2.49401848
68positive regulation of gene expression, epigenetic (GO:0045815)2.48675934
69positive regulation of nuclease activity (GO:0032075)2.47411494
70gene silencing (GO:0016458)2.47363693
71negative regulation of mRNA metabolic process (GO:1903312)2.46798761
72regulation of type I interferon-mediated signaling pathway (GO:0060338)2.46404883
73regulation of RNA stability (GO:0043487)2.46322080
74regulation of SMAD protein import into nucleus (GO:0060390)2.46230111
75regulation of histone H3-K4 methylation (GO:0051569)2.45900133
76embryonic eye morphogenesis (GO:0048048)2.45890203
77response to UV-C (GO:0010225)2.45767541
78cellular response to virus (GO:0098586)2.45689570
79histone lysine methylation (GO:0034968)2.45611197
80histone H3-K9 demethylation (GO:0033169)2.44487850
81adherens junction assembly (GO:0034333)2.44241727
82histone lysine demethylation (GO:0070076)2.43805765
83spliceosomal tri-snRNP complex assembly (GO:0000244)2.43570876
84negative regulation of mRNA processing (GO:0050686)2.43141624
85regulation of translational fidelity (GO:0006450)2.42333400
86T cell selection (GO:0045058)2.41895319
87protein-DNA complex disassembly (GO:0032986)2.41452430
88nucleosome disassembly (GO:0006337)2.41452430
89negative regulation of cell size (GO:0045792)2.40271701
90epithelial cell differentiation involved in prostate gland development (GO:0060742)2.39707250
91regulation of glucose import in response to insulin stimulus (GO:2001273)2.37108641
92protein localization to endosome (GO:0036010)2.36874416
93histone H4 deacetylation (GO:0070933)2.36282400
94definitive hemopoiesis (GO:0060216)2.36146015
95negative thymic T cell selection (GO:0045060)2.36087380
96histone deubiquitination (GO:0016578)2.35195026
97G1 DNA damage checkpoint (GO:0044783)2.34777216
98regulation of histone H3-K9 methylation (GO:0051570)2.34489890
99regulation of monocyte differentiation (GO:0045655)2.33807609
100activation of MAPKKK activity (GO:0000185)2.33497169
101antigen processing and presentation of endogenous antigen (GO:0019883)2.32882808
102morphogenesis of an endothelium (GO:0003159)2.32788981
103endothelial tube morphogenesis (GO:0061154)2.32788981
104polarized epithelial cell differentiation (GO:0030859)2.32559489
105response to epidermal growth factor (GO:0070849)2.31515419
106growth hormone receptor signaling pathway (GO:0060396)2.30916630
107positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.30609627
108antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.30604932
109NIK/NF-kappaB signaling (GO:0038061)2.30477210
110intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.30433838
111chromatin silencing (GO:0006342)2.30139726
112histone demethylation (GO:0016577)2.30049989
113histone H3-K9 modification (GO:0061647)2.29979886
114regulation of nuclease activity (GO:0032069)2.29720589
1153-UTR-mediated mRNA stabilization (GO:0070935)2.29209680
116positive regulation of protein deacetylation (GO:0090312)2.28788783
117maternal placenta development (GO:0001893)2.28540219
118regulation of gamma-delta T cell differentiation (GO:0045586)2.28198054
119T cell lineage commitment (GO:0002360)2.27308898
120stress granule assembly (GO:0034063)2.26541039
121positive regulation of p38MAPK cascade (GO:1900745)2.26127766
122regulation of posttranscriptional gene silencing (GO:0060147)2.25630623
123regulation of gene silencing by miRNA (GO:0060964)2.25630623
124regulation of gene silencing by RNA (GO:0060966)2.25630623
125regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.25511772
126alternative mRNA splicing, via spliceosome (GO:0000380)2.25161695
127negative regulation of gene expression, epigenetic (GO:0045814)2.23618066
128cortical actin cytoskeleton organization (GO:0030866)2.23081274
129negative regulation of RNA splicing (GO:0033119)2.21598092
130histone H4-K16 acetylation (GO:0043984)2.21165649
131negative regulation of fatty acid transport (GO:2000192)2.20181932
132regulation of p38MAPK cascade (GO:1900744)2.18208848
133planar cell polarity pathway involved in neural tube closure (GO:0090179)2.17974729
134cytoskeletal anchoring at plasma membrane (GO:0007016)2.17707732
135negative regulation of histone modification (GO:0031057)2.16219535
136response to fluid shear stress (GO:0034405)2.15856027
137JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.15845419
138thymic T cell selection (GO:0045061)2.15763433
139histone H3-K4 methylation (GO:0051568)2.14987007
140antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.14482418
141antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.14482418
142focal adhesion assembly (GO:0048041)2.12698745
143cell-substrate adherens junction assembly (GO:0007045)2.12698745
144regulation of gamma-delta T cell activation (GO:0046643)2.12654991
145embryonic process involved in female pregnancy (GO:0060136)2.12473658
146positive regulation of gamma-delta T cell activation (GO:0046645)2.12341067
147protein localization to kinetochore (GO:0034501)2.11806106
148epithelial cell fate commitment (GO:0072148)2.11230354
149mitotic nuclear envelope disassembly (GO:0007077)2.11128852

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.79063737
2E2F7_22180533_ChIP-Seq_HELA_Human4.26759597
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.11097744
4STAT6_21828071_ChIP-Seq_BEAS2B_Human4.03001739
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.88998832
6MYC_22102868_ChIP-Seq_BL_Human3.79112241
7* TCF7_22412390_ChIP-Seq_EML_Mouse2.71927448
8* KDM2B_26808549_Chip-Seq_DND41_Human2.65772691
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.52360060
10* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.49793816
11* VDR_21846776_ChIP-Seq_THP-1_Human2.46940410
12* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.46141452
13* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.41477903
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.27928812
15* ELK3_25401928_ChIP-Seq_HUVEC_Human2.13497864
16* KDM2B_26808549_Chip-Seq_JURKAT_Human1.90892336
17ZFP281_27345836_Chip-Seq_ESCs_Mouse1.89113100
18* MAF_26560356_Chip-Seq_TH1_Human1.88383174
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.82513662
20CLOCK_20551151_ChIP-Seq_293T_Human1.81735825
21* UTX_26944678_Chip-Seq_JUKART_Human1.80509956
22* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79249084
23* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.78373402
24KDM2B_26808549_Chip-Seq_K562_Human1.74624940
25KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.73013176
26P300_27058665_Chip-Seq_ZR-75-30cells_Human1.66975883
27ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.66814684
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64362529
29* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.63195174
30* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.62275799
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60159002
32ZNF263_19887448_ChIP-Seq_K562_Human1.59805688
33* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.59430674
34* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.56078310
35* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.56071334
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.56058834
37* VDR_24763502_ChIP-Seq_THP-1_Human1.55453166
38* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.54789200
39NCOR1_26117541_ChIP-Seq_K562_Human1.54023158
40FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.52378042
41KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.49734022
42TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.46530225
43RACK7_27058665_Chip-Seq_MCF-7_Human1.43584045
44SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.39865133
45* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.38308874
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38012604
47* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.37984019
48* LXR_22292898_ChIP-Seq_THP-1_Human1.37862972
49* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35522288
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35341953
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.34614021
52SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.32697590
53MYB_26560356_Chip-Seq_TH1_Human1.32484452
54FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.30736492
55MYB_26560356_Chip-Seq_TH2_Human1.30656127
56NFIB_24661679_ChIP-Seq_LUNG_Mouse1.29352229
57ATF3_27146783_Chip-Seq_COLON_Human1.28677621
58STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.25925814
59FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.24858867
60CREB1_26743006_Chip-Seq_LNCaP_Human1.24803133
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22892837
62* XRN2_22483619_ChIP-Seq_HELA_Human1.21922333
63* CIITA_25753668_ChIP-Seq_RAJI_Human1.21854702
64SMC4_20622854_ChIP-Seq_HELA_Human1.20869109
65SA1_27219007_Chip-Seq_ERYTHROID_Human1.20841779
66MAF_26560356_Chip-Seq_TH2_Human1.20783357
67ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.20127900
68RUNX1_27514584_Chip-Seq_MCF-7_Human1.19780167
69DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19766834
70SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18702391
71* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18380621
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18320736
73TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17368587
74P68_20966046_ChIP-Seq_HELA_Human1.17038380
75HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17034072
76* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.15228887
77FOXO3_23340844_ChIP-Seq_DLD1_Human1.13480175
78RUNX1_22412390_ChIP-Seq_EML_Mouse1.13040568
79* UBF1/2_26484160_Chip-Seq_HMECs_Human1.12858832
80NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12634436
81KDM5A_27292631_Chip-Seq_BREAST_Human1.12223054
82HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11871868
83CHD1_26751641_Chip-Seq_LNCaP_Human1.11822643
84* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11135810
85* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10439881
86MYB_21317192_ChIP-Seq_ERMYB_Mouse1.10304867
87SCL_19346495_ChIP-Seq_HPC-7_Human1.07768222
88E2F1_21310950_ChIP-Seq_MCF-7_Human1.07484103
89TP53_22127205_ChIP-Seq_IMR90_Human1.07458101
90* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07060006
91SALL1_21062744_ChIP-ChIP_HESCs_Human1.06609422
92GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06262942
93GATA6_25053715_ChIP-Seq_YYC3_Human1.05372943
94GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05211306
95SPI1_23127762_ChIP-Seq_K562_Human1.03459930
96* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02987069
97KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02849093
98* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02587537
99GATA1_19941826_ChIP-Seq_K562_Human1.02367109
100* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02107301
101ESR2_21235772_ChIP-Seq_MCF-7_Human1.01456555
102RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01317011
103ELF1_20517297_ChIP-Seq_JURKAT_Human1.01146007
104* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.01051828
105UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00793246
106* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99484591
107MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99256114
108* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99197044
109TET1_21451524_ChIP-Seq_MESCs_Mouse0.98163578
110KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97671595
111MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.96751349
112NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96330073
113* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96251352
114MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.95807108
115* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.94977047
116POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94414181
117PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93227017
118* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93000849
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91742436
120DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91168712
121NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.90878305

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005076_abnormal_cell_differentiation3.78287571
2MP0002009_preneoplasia3.08694647
3MP0003705_abnormal_hypodermis_morpholog2.95927694
4MP0003303_peritoneal_inflammation2.93561449
5MP0009278_abnormal_bone_marrow2.86837744
6MP0010352_gastrointestinal_tract_polyps2.76133406
7MP0003300_gastrointestinal_ulcer2.56869644
8MP0005451_abnormal_body_composition2.28533668
9MP0010307_abnormal_tumor_latency2.26479921
10MP0000733_abnormal_muscle_development1.93630356
11MP0003566_abnormal_cell_adhesion1.88087354
12MP0000537_abnormal_urethra_morphology1.87317096
13MP0002653_abnormal_ependyma_morphology1.84847734
14MP0001849_ear_inflammation1.80788325
15MP0002249_abnormal_larynx_morphology1.76722444
16MP0004808_abnormal_hematopoietic_stem1.71481210
17MP0003091_abnormal_cell_migration1.66224379
18MP0001346_abnormal_lacrimal_gland1.64738565
19MP0005409_darkened_coat_color1.63059664
20MP0004197_abnormal_fetal_growth/weight/1.61160191
21MP0002877_abnormal_melanocyte_morpholog1.56686202
22MP0009333_abnormal_splenocyte_physiolog1.55702201
23MP0010234_abnormal_vibrissa_follicle1.54522402
24MP0003111_abnormal_nucleus_morphology1.52148942
25MP0004233_abnormal_muscle_weight1.51537445
26MP0010030_abnormal_orbit_morphology1.49708225
27* MP0000350_abnormal_cell_proliferation1.47869884
28MP0000569_abnormal_digit_pigmentation1.47339362
29MP0001730_embryonic_growth_arrest1.46486099
30* MP0008961_abnormal_basal_metabolism1.44635703
31MP0003115_abnormal_respiratory_system1.42452234
32MP0000428_abnormal_craniofacial_morphol1.41223522
33MP0001835_abnormal_antigen_presentation1.39447616
34MP0004185_abnormal_adipocyte_glucose1.39320184
35MP0002084_abnormal_developmental_patter1.39005506
36MP0001915_intracranial_hemorrhage1.34854081
37MP0002006_tumorigenesis1.34688328
38MP0001545_abnormal_hematopoietic_system1.33811812
39MP0005397_hematopoietic_system_phenotyp1.33811812
40MP0008007_abnormal_cellular_replicative1.33199914
41MP0002086_abnormal_extraembryonic_tissu1.32389170
42MP0005000_abnormal_immune_tolerance1.31982000
43MP0002088_abnormal_embryonic_growth/wei1.31603169
44MP0003984_embryonic_growth_retardation1.31335520
45* MP0002085_abnormal_embryonic_tissue1.30762469
46MP0000678_abnormal_parathyroid_gland1.30459350
47MP0001672_abnormal_embryogenesis/_devel1.29944417
48MP0005380_embryogenesis_phenotype1.29944417
49MP0002396_abnormal_hematopoietic_system1.29602704
50MP0008260_abnormal_autophagy1.29457532
51MP0005666_abnormal_adipose_tissue1.28418601
52MP0008438_abnormal_cutaneous_collagen1.23922061
53MP0005623_abnormal_meninges_morphology1.22130010
54MP0000685_abnormal_immune_system1.21941916
55MP0000703_abnormal_thymus_morphology1.21402816
56MP0005257_abnormal_intraocular_pressure1.19498236
57MP0005023_abnormal_wound_healing1.18839713
58* MP0003077_abnormal_cell_cycle1.17889556
59MP0002925_abnormal_cardiovascular_devel1.17586191
60MP0000716_abnormal_immune_system1.17545563
61MP0004381_abnormal_hair_follicle1.17408844
62MP0004947_skin_inflammation1.17252201
63MP0002420_abnormal_adaptive_immunity1.13835130
64MP0005058_abnormal_lysosome_morphology1.13807645
65* MP0001697_abnormal_embryo_size1.12116276
66MP0001819_abnormal_immune_cell1.11819004
67MP0000767_abnormal_smooth_muscle1.11555373
68MP0002429_abnormal_blood_cell1.11553246
69* MP0002723_abnormal_immune_serum1.11293779
70MP0004510_myositis1.07009493
71MP0003123_paternal_imprinting1.06854726
72MP0003448_altered_tumor_morphology1.06369369
73MP0003828_pulmonary_edema1.06199384
74MP0009703_decreased_birth_body1.05958904
75MP0009053_abnormal_anal_canal1.05938742
76MP0002092_abnormal_eye_morphology1.04804628
77* MP0000313_abnormal_cell_death1.04722877
78MP0009672_abnormal_birth_weight1.03618783
79MP0002398_abnormal_bone_marrow1.01839229
80MP0003045_fibrosis1.01777803
81* MP0002080_prenatal_lethality1.00622125
82MP0003453_abnormal_keratinocyte_physiol1.00600405
83MP0003119_abnormal_digestive_system1.00361553
84MP0010094_abnormal_chromosome_stability1.00251305
85MP0000689_abnormal_spleen_morphology0.98894870
86MP0001800_abnormal_humoral_immune0.98825961
87MP0005025_abnormal_response_to0.98817162
88MP0002896_abnormal_bone_mineralization0.98801611
89MP0009840_abnormal_foam_cell0.98386843
90MP0002166_altered_tumor_susceptibility0.97825892
91* MP0005375_adipose_tissue_phenotype0.96121183
92MP0003935_abnormal_craniofacial_develop0.96016679
93MP0003763_abnormal_thymus_physiology0.95967778
94MP0008057_abnormal_DNA_replication0.94616942
95MP0003279_aneurysm0.94277599
96MP0005621_abnormal_cell_physiology0.92995604
97MP0000432_abnormal_head_morphology0.92654510
98MP0002419_abnormal_innate_immunity0.92635503
99MP0010630_abnormal_cardiac_muscle0.91692478
100MP0002697_abnormal_eye_size0.91609165
101MP0005083_abnormal_biliary_tract0.89889294
102MP0009931_abnormal_skin_appearance0.89457815
103MP0005387_immune_system_phenotype0.88554997
104MP0001790_abnormal_immune_system0.88554997
105MP0002111_abnormal_tail_morphology0.87623495
106MP0004957_abnormal_blastocyst_morpholog0.87542695
107MP0001851_eye_inflammation0.87495962
108MP0008770_decreased_survivor_rate0.87255876
109MP0003283_abnormal_digestive_organ0.87140093
110MP0006054_spinal_hemorrhage0.86837705
111MP0005671_abnormal_response_to0.86832375
112MP0002452_abnormal_antigen_presenting0.85481406
113MP0002998_abnormal_bone_remodeling0.85191431
114MP0002970_abnormal_white_adipose0.84202860
115MP0008995_early_reproductive_senescence0.83619955
116MP0002132_abnormal_respiratory_system0.83561883
117MP0001348_abnormal_lacrimal_gland0.83208969
118MP0010155_abnormal_intestine_physiology0.83147509
119MP0000490_abnormal_crypts_of0.82873364
120MP0002722_abnormal_immune_system0.82169929
121MP0004858_abnormal_nervous_system0.82132716
122MP0002928_abnormal_bile_duct0.81654509
123MP0003943_abnormal_hepatobiliary_system0.81291074
124MP0005508_abnormal_skeleton_morphology0.79139994
125MP0003693_abnormal_embryo_hatching0.79114161
126MP0002116_abnormal_craniofacial_bone0.78934698
127MP0000858_altered_metastatic_potential0.78521533
128MP0002405_respiratory_system_inflammati0.77357999
129MP0001784_abnormal_fluid_regulation0.76978753
130MP0002089_abnormal_postnatal_growth/wei0.76237885
131MP0001614_abnormal_blood_vessel0.74634665
132MP0003172_abnormal_lysosome_physiology0.74609737
133MP0005248_abnormal_Harderian_gland0.74558880
134MP0001873_stomach_inflammation0.74416752
135MP0003890_abnormal_embryonic-extraembry0.73547745
136MP0005310_abnormal_salivary_gland0.73361322
137MP0004264_abnormal_extraembryonic_tissu0.73328611
138MP0002019_abnormal_tumor_incidence0.72561388
139MP0003436_decreased_susceptibility_to0.72223139

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)3.50692657
2Hyperacusis (HP:0010780)3.29715516
3Broad face (HP:0000283)3.15211938
4Shallow orbits (HP:0000586)3.13642408
5Septate vagina (HP:0001153)3.02419568
6Obstructive sleep apnea (HP:0002870)2.91464721
7Sparse lateral eyebrow (HP:0005338)2.87988207
8Pseudobulbar signs (HP:0002200)2.77772367
9Abnormality of the distal phalanx of the thumb (HP:0009617)2.76897305
10Dysmetric saccades (HP:0000641)2.73202727
11Abnormality of the fingertips (HP:0001211)2.69821515
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.69218393
13Short 4th metacarpal (HP:0010044)2.69218393
14Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.64140424
15Hematochezia (HP:0002573)2.51690695
16Hand muscle atrophy (HP:0009130)2.41219045
17Lip pit (HP:0100267)2.41209705
18Renal duplication (HP:0000075)2.39100521
19Abnormality of the phalanges of the hallux (HP:0010057)2.32551797
20Macroorchidism (HP:0000053)2.27825878
21Elfin facies (HP:0004428)2.27700497
22Segmental peripheral demyelination/remyelination (HP:0003481)2.27661230
23Renovascular hypertension (HP:0100817)2.27453662
24Upper limb amyotrophy (HP:0009129)2.24718992
25Distal upper limb amyotrophy (HP:0007149)2.24718992
26Flat acetabular roof (HP:0003180)2.24440251
27Heterotopia (HP:0002282)2.22894498
28Subacute progressive viral hepatitis (HP:0006572)2.22519354
29Neonatal hypoglycemia (HP:0001998)2.18523132
30Abnormality of the columella (HP:0009929)2.17877214
31Genu recurvatum (HP:0002816)2.16449290
32Long eyelashes (HP:0000527)2.15571669
33Deep palmar crease (HP:0006191)2.13484639
34Increased density of long bones (HP:0006392)2.13111497
35Increased nuchal translucency (HP:0010880)2.10995229
36Ulnar bowing (HP:0003031)2.09992848
37Overriding aorta (HP:0002623)2.06872724
38Bowel diverticulosis (HP:0005222)2.06614742
39Urethral obstruction (HP:0000796)2.04901772
40Bladder diverticulum (HP:0000015)2.04765848
41Abnormality of the 4th metacarpal (HP:0010012)2.04329842
42Recurrent viral infections (HP:0004429)2.02513765
43Vertebral arch anomaly (HP:0008438)2.00943678
44Eczematoid dermatitis (HP:0000976)2.00727768
45Mitral valve prolapse (HP:0001634)2.00667611
46Aortic aneurysm (HP:0004942)1.99921010
47Trigonocephaly (HP:0000243)1.98626456
48Deviation of the thumb (HP:0009603)1.96836982
49Slow saccadic eye movements (HP:0000514)1.95693828
50Malignant gastrointestinal tract tumors (HP:0006749)1.94860983
51Gastrointestinal carcinoma (HP:0002672)1.94860983
52Rectal prolapse (HP:0002035)1.94243783
53Persistence of primary teeth (HP:0006335)1.94102743
54Increased IgE level (HP:0003212)1.93214797
55Deep philtrum (HP:0002002)1.93177452
56Proximal placement of thumb (HP:0009623)1.93138922
57Ureteral stenosis (HP:0000071)1.93127875
58Disproportionate tall stature (HP:0001519)1.92510146
59Ankle contracture (HP:0006466)1.90490424
60Protrusio acetabuli (HP:0003179)1.89906331
61Germ cell neoplasia (HP:0100728)1.88888143
62Fatigue (HP:0012378)1.88155871
63Ependymoma (HP:0002888)1.88005208
64Anal stenosis (HP:0002025)1.86677474
65Gastrointestinal inflammation (HP:0004386)1.86252785
66Astrocytoma (HP:0009592)1.85176695
67Abnormality of the astrocytes (HP:0100707)1.85176695
68Aneurysm (HP:0002617)1.84754778
69Hallux valgus (HP:0001822)1.83255159
70Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.82262197
71Insomnia (HP:0100785)1.82087310
72Abnormality of the thoracic spine (HP:0100711)1.81982713
73Progressive external ophthalmoplegia (HP:0000590)1.81859551
74Deviation of the hallux (HP:0010051)1.81433749
75Asymmetry of the thorax (HP:0001555)1.80732011
76Bowel incontinence (HP:0002607)1.80469242
77Gastrointestinal stroma tumor (HP:0100723)1.77218169
78Dilatation of the ascending aorta (HP:0005111)1.77044387
79Thin bony cortex (HP:0002753)1.76507721
80Emphysema (HP:0002097)1.76175651
81Ureteral obstruction (HP:0006000)1.76023479
82Abnormality of the lower motor neuron (HP:0002366)1.75668461
83Patellar dislocation (HP:0002999)1.75645213
84Hypercortisolism (HP:0001578)1.75421518
85Distal lower limb amyotrophy (HP:0008944)1.74841017
86Broad distal phalanx of finger (HP:0009836)1.74694177
87Pointed chin (HP:0000307)1.72617723
88Narrow palate (HP:0000189)1.72457206
89Uterine leiomyosarcoma (HP:0002891)1.71906583
90Leiomyosarcoma (HP:0100243)1.71906583
91Abnormality of the intervertebral disk (HP:0005108)1.71843942
92Abnormal large intestine physiology (HP:0012700)1.71326780
93Progressive muscle weakness (HP:0003323)1.70685695
94Flat cornea (HP:0007720)1.70005898
95Abnormal tarsal ossification (HP:0008369)1.69431082
96Broad thumb (HP:0011304)1.68001285
97Flattened epiphyses (HP:0003071)1.66484745
98Selective tooth agenesis (HP:0001592)1.66372489
99High pitched voice (HP:0001620)1.66226000
100Bicuspid aortic valve (HP:0001647)1.65789252
101Viral hepatitis (HP:0006562)1.65031097
102Sandal gap (HP:0001852)1.64899702
103Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.64084360
104Arnold-Chiari malformation (HP:0002308)1.63788953
105Overlapping toe (HP:0001845)1.63476292
106Transitional cell carcinoma of the bladder (HP:0006740)1.62871915
107Abnormality of the distal phalanges of the toes (HP:0010182)1.62450129
108Enlarged penis (HP:0000040)1.62125702
109Abnormal foot bone ossification (HP:0010675)1.61845601
110Hypertensive crisis (HP:0100735)1.61108480
111Large earlobe (HP:0009748)1.60496873
112Long toe (HP:0010511)1.60425351
113Volvulus (HP:0002580)1.60204768
114Spina bifida occulta (HP:0003298)1.59667822
115Broad metatarsal (HP:0001783)1.59277522
116Skull defect (HP:0001362)1.59099359
117Cellulitis (HP:0100658)1.58353659
118Abnormality of the nasal septum (HP:0000419)1.58302543
119Inflammation of the large intestine (HP:0002037)1.58205909
120Prominent nose (HP:0000448)1.57887418
121Abnormality of the peritoneum (HP:0002585)1.57526877
122Osteolytic defects of the phalanges of the hand (HP:0009771)1.57510660
123Osteolytic defects of the hand bones (HP:0009699)1.57510660
124Self-mutilation (HP:0000742)1.57365793
125High anterior hairline (HP:0009890)1.57318624
126Premature rupture of membranes (HP:0001788)1.56455829
127Bladder carcinoma (HP:0002862)1.56402370
128Bladder neoplasm (HP:0009725)1.56402370
129Abnormality of the parietal bone (HP:0002696)1.56348490
130Dislocated radial head (HP:0003083)1.56279208
131Radial bowing (HP:0002986)1.56242190
132Abnormal number of incisors (HP:0011064)1.56127606
133Onion bulb formation (HP:0003383)1.56123037
134Broad palm (HP:0001169)1.55811701
135Skin tags (HP:0010609)1.55497664
136Seborrheic dermatitis (HP:0001051)1.55228842
137Abnormality of the radial head (HP:0003995)1.54581459
138Vertebral fusion (HP:0002948)1.54115924
139Low anterior hairline (HP:0000294)1.54024596
140Megalocornea (HP:0000485)1.53875824
141Limited elbow extension (HP:0001377)1.53429391
142Abnormality of the aortic arch (HP:0012303)1.52633262
143Truncal obesity (HP:0001956)1.52505730
144Advanced eruption of teeth (HP:0006288)1.52493997
145Neoplasm of the adrenal cortex (HP:0100641)1.52448325
146Bowed forearm bones (HP:0003956)1.52288919
147Bowing of the arm (HP:0006488)1.52288919
148Abnormality of chromosome segregation (HP:0002916)1.52274284
149Metaphyseal cupping (HP:0003021)1.51752778
150Supernumerary ribs (HP:0005815)1.51569003
151Thoracic kyphosis (HP:0002942)1.51243781
152Acute myeloid leukemia (HP:0004808)1.50996108
153Obsessive-compulsive behavior (HP:0000722)1.50918614
154Spinal cord lesions (HP:0100561)1.49718709
155Syringomyelia (HP:0003396)1.49718709
156Thin ribs (HP:0000883)1.49343778
157Nasal polyposis (HP:0100582)1.48885834
158Absent frontal sinuses (HP:0002688)1.48252054
159Abnormality of the humeroradial joint (HP:0100744)1.48226567
160Flared metaphyses (HP:0003015)1.47978892
161Abnormality of the gastric mucosa (HP:0004295)1.47078148
162Somatic mutation (HP:0001428)1.46436961
163Ankyloglossia (HP:0010296)1.45982655
164Long palpebral fissure (HP:0000637)1.45831692
165Colitis (HP:0002583)1.45226998
166Precocious puberty (HP:0000826)1.44547984
167Hyperparathyroidism (HP:0000843)1.43975874
168Short 5th finger (HP:0009237)1.43675426
169Neuronal loss in central nervous system (HP:0002529)1.42667736

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.30585020
2PRPF4B3.41621817
3MAP3K103.28904756
4TRIB33.26765652
5SMG13.11160853
6EEF2K2.88689153
7PASK2.76383249
8PKN22.63688143
9BRD42.33117705
10ERN12.19855955
11ICK2.17421688
12LATS11.91595544
13RIPK41.88861484
14RIPK11.81787610
15PTK61.72386141
16CAMK1G1.71643769
17PDGFRA1.68435114
18ALK1.58726377
19STK101.56477644
20MTOR1.55184547
21NEK21.54479391
22IRAK31.52459029
23MAP4K11.45557515
24CAMK1D1.45316790
25SIK21.39285650
26EPHB11.30005023
27MAP3K131.29662461
28MAP3K141.28976882
29TAOK11.24388689
30BMX1.23467351
31SCYL21.22981480
32SIK31.21947241
33MAP2K31.20553292
34FGFR41.16492513
35CDK61.16368386
36STK31.14782138
37TYRO31.14744290
38TTN1.14479386
39PRKD31.12706982
40SIK11.11590732
41PAK21.08081954
42PAK41.07188403
43MAP2K21.06018697
44PDGFRB1.05782854
45EPHA21.05380451
46FGFR31.05014010
47LATS21.04177146
48DMPK1.03776456
49AKT30.99266596
50IRAK40.96899341
51CDC70.96419912
52CAMKK10.94487586
53MAPK110.94242609
54PRKD20.91370027
55LRRK20.91038259
56DDR20.89601978
57CDK40.89427862
58CDK90.88615199
59CDC42BPA0.88430946
60DYRK1B0.87600797
61PDPK10.87000725
62PNCK0.85964980
63CHUK0.82688267
64TAOK20.80075699
65TGFBR20.79426603
66TESK20.79303278
67MAP3K30.78282397
68JAK30.78097595
69JAK10.77040024
70TYK20.76064442
71TESK10.75609397
72KSR20.74015471
73PIM10.72866142
74MAP3K10.71150876
75MAP3K80.69963909
76PTK20.69889395
77PDK10.69620471
78BLK0.66754197
79RET0.66720887
80RPS6KL10.65738920
81RPS6KC10.65738920
82HIPK20.65310518
83CHEK10.63519347
84SGK30.62228541
85ITK0.61550303
86FGFR20.61055458
87WNK10.60733950
88HCK0.60252789
89EPHB20.59713421
90KSR10.59596282
91IRAK20.58780547
92RAF10.57395724
93FGFR10.56452886
94ZAP700.55334950
95MARK30.54924176
96NEK60.54770291
97TAOK30.54155643
98GRK60.53927985
99IKBKE0.53181347
100RPS6KA20.52961839
101CDK70.51161071
102RPS6KA40.50978340
103RPS6KA60.50897585
104MARK20.50867419
105STK380.50851786
106* CDK20.49809729
107TNK20.49638710
108MAPK100.49333338
109MAP3K90.48791088
110ATR0.48766915
111TSSK60.48607742
112MAPK150.48310746
113JAK20.47873097
114PAK60.47495732
115RPS6KB20.46639205
116BTK0.46127701
117STK40.46051202
118TBK10.45511036
119PRKCH0.44867090
120RPS6KA10.43964177
121IKBKB0.43448956
122CSK0.42807453
123MAP3K20.42085280
124MELK0.41703723
125PIM20.41627280
126MAPK10.41420665
127CSF1R0.40086734
128MAPK70.39890023
129CSNK1D0.38966025
130MAP3K70.38790488
131MAPK120.38228682
132ATM0.38165997
133GSK3A0.38051257
134MAPK80.37554141
135CLK10.37261441
136EPHA30.35462379
137CDK10.33441368
138* GSK3B0.33031193

Predicted pathways (KEGG)

RankGene SetZ-score
1Chronic myeloid leukemia_Homo sapiens_hsa052202.04941485
2Notch signaling pathway_Homo sapiens_hsa043301.77088954
3MicroRNAs in cancer_Homo sapiens_hsa052061.67207057
4B cell receptor signaling pathway_Homo sapiens_hsa046621.64936159
5Dorso-ventral axis formation_Homo sapiens_hsa043201.56241444
6Small cell lung cancer_Homo sapiens_hsa052221.54630209
7Colorectal cancer_Homo sapiens_hsa052101.50440635
8Endometrial cancer_Homo sapiens_hsa052131.48577104
9mTOR signaling pathway_Homo sapiens_hsa041501.45184987
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.42438994
11Osteoclast differentiation_Homo sapiens_hsa043801.41970264
12Pancreatic cancer_Homo sapiens_hsa052121.39569374
13Toxoplasmosis_Homo sapiens_hsa051451.38109695
14Lysine degradation_Homo sapiens_hsa003101.37730416
15Other glycan degradation_Homo sapiens_hsa005111.37691448
16Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.37079046
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.34520596
18Adherens junction_Homo sapiens_hsa045201.33851702
19Proteoglycans in cancer_Homo sapiens_hsa052051.33340089
20Acute myeloid leukemia_Homo sapiens_hsa052211.32887709
21Neurotrophin signaling pathway_Homo sapiens_hsa047221.31434251
22Antigen processing and presentation_Homo sapiens_hsa046121.30325621
23Bladder cancer_Homo sapiens_hsa052191.29384261
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.28858797
25Non-small cell lung cancer_Homo sapiens_hsa052231.27413428
26Renal cell carcinoma_Homo sapiens_hsa052111.26761076
27Thyroid hormone signaling pathway_Homo sapiens_hsa049191.26066466
28Leishmaniasis_Homo sapiens_hsa051401.25907973
29Basal cell carcinoma_Homo sapiens_hsa052171.25317393
30HTLV-I infection_Homo sapiens_hsa051661.24346926
31Viral myocarditis_Homo sapiens_hsa054161.23721294
32T cell receptor signaling pathway_Homo sapiens_hsa046601.22257374
33mRNA surveillance pathway_Homo sapiens_hsa030151.21341890
34Prostate cancer_Homo sapiens_hsa052151.20574329
35Apoptosis_Homo sapiens_hsa042101.19401534
36Hepatitis B_Homo sapiens_hsa051611.19279690
37Hippo signaling pathway_Homo sapiens_hsa043901.19229085
38Focal adhesion_Homo sapiens_hsa045101.17768524
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17494355
40Glioma_Homo sapiens_hsa052141.17081947
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16889668
42VEGF signaling pathway_Homo sapiens_hsa043701.16704756
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.16029285
44Hepatitis C_Homo sapiens_hsa051601.14178995
45Viral carcinogenesis_Homo sapiens_hsa052031.13290507
46Prolactin signaling pathway_Homo sapiens_hsa049171.12486795
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11597207
48TNF signaling pathway_Homo sapiens_hsa046681.10740177
49Estrogen signaling pathway_Homo sapiens_hsa049151.06118831
50Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04126722
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02768145
52Type II diabetes mellitus_Homo sapiens_hsa049301.02325250
53Herpes simplex infection_Homo sapiens_hsa051681.01858459
54Inositol phosphate metabolism_Homo sapiens_hsa005621.00638124
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.98364796
56Insulin resistance_Homo sapiens_hsa049310.97987395
57Toll-like receptor signaling pathway_Homo sapiens_hsa046200.93444929
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.92464951
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92278603
60Influenza A_Homo sapiens_hsa051640.92046604
61Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90958919
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.90729523
63Pathways in cancer_Homo sapiens_hsa052000.89836187
64Measles_Homo sapiens_hsa051620.88827145
65GnRH signaling pathway_Homo sapiens_hsa049120.88451264
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88371716
67Amoebiasis_Homo sapiens_hsa051460.86983603
68Allograft rejection_Homo sapiens_hsa053300.86926391
69FoxO signaling pathway_Homo sapiens_hsa040680.86161906
70Hedgehog signaling pathway_Homo sapiens_hsa043400.86047023
71Cell cycle_Homo sapiens_hsa041100.86037037
72p53 signaling pathway_Homo sapiens_hsa041150.85612795
73TGF-beta signaling pathway_Homo sapiens_hsa043500.84914296
74Thyroid cancer_Homo sapiens_hsa052160.84733768
75Prion diseases_Homo sapiens_hsa050200.84164004
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.84044477
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82678476
78ECM-receptor interaction_Homo sapiens_hsa045120.82385929
79Spliceosome_Homo sapiens_hsa030400.82138684
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81860624
81ErbB signaling pathway_Homo sapiens_hsa040120.80336750
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.80238983
83AMPK signaling pathway_Homo sapiens_hsa041520.80148987
84Chemokine signaling pathway_Homo sapiens_hsa040620.79876963
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79159612
86RNA transport_Homo sapiens_hsa030130.78703198
87Fatty acid biosynthesis_Homo sapiens_hsa000610.78456252
88Primary immunodeficiency_Homo sapiens_hsa053400.77939097
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77758254
90Autoimmune thyroid disease_Homo sapiens_hsa053200.77147061
91Graft-versus-host disease_Homo sapiens_hsa053320.77015521
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76486714
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76240814
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75243245
95Shigellosis_Homo sapiens_hsa051310.74410976
96HIF-1 signaling pathway_Homo sapiens_hsa040660.73426950
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72689628
98Wnt signaling pathway_Homo sapiens_hsa043100.71210845
99MAPK signaling pathway_Homo sapiens_hsa040100.70504915
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70122434
101Endocytosis_Homo sapiens_hsa041440.69837362
102Glycosaminoglycan degradation_Homo sapiens_hsa005310.69378994
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69332384
104Tuberculosis_Homo sapiens_hsa051520.68785029
105Platelet activation_Homo sapiens_hsa046110.68705731
106Epstein-Barr virus infection_Homo sapiens_hsa051690.65941508
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.64502666
108Axon guidance_Homo sapiens_hsa043600.63815294
109Insulin signaling pathway_Homo sapiens_hsa049100.62113774
110Rap1 signaling pathway_Homo sapiens_hsa040150.61799799
111Salmonella infection_Homo sapiens_hsa051320.61525970
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.61514027
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61497718
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.59714577
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59684459
116Legionellosis_Homo sapiens_hsa051340.59358344
117Choline metabolism in cancer_Homo sapiens_hsa052310.59262987
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58461701
119Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56386882
120Long-term potentiation_Homo sapiens_hsa047200.55298835
121Fructose and mannose metabolism_Homo sapiens_hsa000510.50200761

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »