BRD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.62171594
2protein localization to kinetochore (GO:0034501)4.91364206
3regulation of nuclear cell cycle DNA replication (GO:0033262)4.68291564
4daunorubicin metabolic process (GO:0044597)4.55452985
5polyketide metabolic process (GO:0030638)4.55452985
6doxorubicin metabolic process (GO:0044598)4.55452985
7nucleobase catabolic process (GO:0046113)4.29764036
8mitotic sister chromatid segregation (GO:0000070)4.15775750
9regulation of telomere maintenance via telomerase (GO:0032210)4.07283601
10DNA unwinding involved in DNA replication (GO:0006268)4.04055333
11histone H4-K8 acetylation (GO:0043982)4.01079045
12histone H4-K5 acetylation (GO:0043981)4.01079045
13histone H4-K12 acetylation (GO:0043983)3.99356955
14limb bud formation (GO:0060174)3.98923071
15DNA replication checkpoint (GO:0000076)3.96075764
16protein localization to chromosome, centromeric region (GO:0071459)3.93549818
17negative regulation of epidermis development (GO:0045683)3.86822658
18DNA replication-dependent nucleosome organization (GO:0034723)3.84365377
19DNA replication-dependent nucleosome assembly (GO:0006335)3.84365377
20negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.84331761
21DNA damage response, detection of DNA damage (GO:0042769)3.80910177
22positive regulation of DNA-dependent DNA replication (GO:2000105)3.78716684
23sister chromatid segregation (GO:0000819)3.75537035
24somite rostral/caudal axis specification (GO:0032525)3.69054262
25presynaptic membrane assembly (GO:0097105)3.67688861
26cullin deneddylation (GO:0010388)3.66346579
27heterochromatin organization (GO:0070828)3.65539462
28negative regulation of cell cycle G2/M phase transition (GO:1902750)3.64983801
29negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.62346119
30notochord development (GO:0030903)3.55210950
31regulation of mammary gland epithelial cell proliferation (GO:0033599)3.51989845
32rRNA transcription (GO:0009303)3.48249801
33negative regulation of telomere maintenance (GO:0032205)3.45820121
34nuclear pore complex assembly (GO:0051292)3.45612632
35behavioral response to nicotine (GO:0035095)3.41085266
36DNA replication initiation (GO:0006270)3.38557614
37rRNA modification (GO:0000154)3.36644617
38negative regulation of telomerase activity (GO:0051974)3.35707474
39rRNA methylation (GO:0031167)3.35008845
40nucleosome disassembly (GO:0006337)3.32882019
41protein-DNA complex disassembly (GO:0032986)3.32882019
42nuclear pore organization (GO:0006999)3.32457521
43pre-miRNA processing (GO:0031054)3.28109652
44protein deneddylation (GO:0000338)3.26378126
45formation of translation preinitiation complex (GO:0001731)3.24960617
46regulation of telomere maintenance (GO:0032204)3.24000528
47primitive streak formation (GO:0090009)3.22870646
48regulation of development, heterochronic (GO:0040034)3.20151872
49sequestering of actin monomers (GO:0042989)3.19733607
50presynaptic membrane organization (GO:0097090)3.18411783
51somite development (GO:0061053)3.17875087
52neuron cell-cell adhesion (GO:0007158)3.15764188
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.15506602
54negative regulation of epidermal cell differentiation (GO:0045605)3.13696165
55spliceosomal complex assembly (GO:0000245)3.13166013
56maintenance of protein location in nucleus (GO:0051457)3.12368473
57ribosome biogenesis (GO:0042254)3.11367568
58chromatin assembly (GO:0031497)3.11038678
59DNA double-strand break processing (GO:0000729)3.10939164
60regulation of double-strand break repair (GO:2000779)3.07985398
61DNA duplex unwinding (GO:0032508)3.07542506
62ribosomal small subunit biogenesis (GO:0042274)3.07299680
63histone H4-K16 acetylation (GO:0043984)3.07252509
64DNA geometric change (GO:0032392)3.06638514
65histone arginine methylation (GO:0034969)3.03165956
66regulation of double-strand break repair via homologous recombination (GO:0010569)3.01099590
67negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.00217896
68protein neddylation (GO:0045116)2.97637700
69neural tube formation (GO:0001841)2.93812139
70postsynaptic membrane organization (GO:0001941)2.91544986
71cell fate commitment involved in formation of primary germ layer (GO:0060795)2.90179873
72regulation of cilium movement (GO:0003352)2.90104421
73regulation of gene silencing by RNA (GO:0060966)2.89638545
74regulation of posttranscriptional gene silencing (GO:0060147)2.89638545
75regulation of gene silencing by miRNA (GO:0060964)2.89638545
76negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.89561936
77negative regulation of translation, ncRNA-mediated (GO:0040033)2.89561936
78regulation of translation, ncRNA-mediated (GO:0045974)2.89561936
79mitotic chromosome condensation (GO:0007076)2.89129513
80histone H2A acetylation (GO:0043968)2.87916409
81nonmotile primary cilium assembly (GO:0035058)2.87320911
82retinal ganglion cell axon guidance (GO:0031290)2.86474156
83forebrain neuron differentiation (GO:0021879)2.86184013
84olfactory bulb development (GO:0021772)2.86183183
85DNA strand elongation involved in DNA replication (GO:0006271)2.85396637
86peptidyl-arginine omega-N-methylation (GO:0035247)2.84831484
87spindle assembly checkpoint (GO:0071173)2.83799339
88establishment of mitochondrion localization (GO:0051654)2.82916816
89paraxial mesoderm development (GO:0048339)2.82795953
90ribonucleoprotein complex biogenesis (GO:0022613)2.81663882
91vocalization behavior (GO:0071625)2.81004092
92protein-cofactor linkage (GO:0018065)2.80523315
93mitotic metaphase plate congression (GO:0007080)2.79983303
94regulation of timing of cell differentiation (GO:0048505)2.79667538
95ATP-dependent chromatin remodeling (GO:0043044)2.79630462
96negative regulation of RNA splicing (GO:0033119)2.76688694
97spinal cord development (GO:0021510)2.74829993
98intraciliary transport (GO:0042073)2.74547266
99response to pheromone (GO:0019236)2.74461018
100regulation of translation in response to stress (GO:0043555)2.73594420
101RNA stabilization (GO:0043489)2.73418835
102mRNA stabilization (GO:0048255)2.73418835
103DNA strand elongation (GO:0022616)2.73175425
104regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.72669411
105kidney morphogenesis (GO:0060993)2.71801980
106negative regulation of chromosome segregation (GO:0051985)2.71637953
107nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.71498295
108negative regulation of mitotic sister chromatid separation (GO:2000816)2.70514222
109negative regulation of mitotic sister chromatid segregation (GO:0033048)2.70514222
110negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.70514222
111negative regulation of sister chromatid segregation (GO:0033046)2.70514222
112spliceosomal snRNP assembly (GO:0000387)2.70093547
113pseudouridine synthesis (GO:0001522)2.69808004
114mitotic nuclear envelope disassembly (GO:0007077)2.68909414
115exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.68551840
116regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.68432677
117spindle checkpoint (GO:0031577)2.68418679
118chromatin assembly or disassembly (GO:0006333)2.68403519
119DNA replication-independent nucleosome assembly (GO:0006336)2.68354676
120DNA replication-independent nucleosome organization (GO:0034724)2.68354676
121mitotic spindle assembly checkpoint (GO:0007094)2.67449023
122negative regulation of mRNA processing (GO:0050686)2.66883842
123DNA integration (GO:0015074)2.65912729
124chromatin remodeling at centromere (GO:0031055)2.65855639
125aminoglycoside antibiotic metabolic process (GO:0030647)2.65812733
126protein localization to chromosome (GO:0034502)2.65307934
127regulation of DNA-dependent DNA replication (GO:0090329)2.64626974
128DNA conformation change (GO:0071103)2.63842517
129attachment of spindle microtubules to kinetochore (GO:0008608)2.62855922
130nucleobase biosynthetic process (GO:0046112)2.62590871
131mRNA splice site selection (GO:0006376)2.61892044
132negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.61720304
133regulation of mitotic spindle checkpoint (GO:1903504)2.61507690
134regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.61507690
135regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.60879336
136negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.60243530
137kinetochore organization (GO:0051383)2.59789245
138microtubule depolymerization (GO:0007019)2.58999173
139mitotic recombination (GO:0006312)2.58991968
140mitotic spindle checkpoint (GO:0071174)2.58151998
141head development (GO:0060322)2.57909861
142hindbrain development (GO:0030902)2.56946796
143protein polyglutamylation (GO:0018095)2.56668638
144gamma-aminobutyric acid transport (GO:0015812)2.53734193
145sympathetic nervous system development (GO:0048485)2.51481271
146axonal fasciculation (GO:0007413)2.48979850
147regulation of collateral sprouting (GO:0048670)2.48886473
148negative regulation of transcription regulatory region DNA binding (GO:2000678)2.48190743
149ubiquinone metabolic process (GO:0006743)2.48092588
150calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.46487849
151CENP-A containing nucleosome assembly (GO:0034080)2.46078887
152chaperone-mediated protein transport (GO:0072321)2.46075805
153synapse assembly (GO:0007416)2.45039589
154replication fork processing (GO:0031297)2.44469187
155L-serine metabolic process (GO:0006563)2.43234969
156somatic diversification of immune receptors via somatic mutation (GO:0002566)2.43064046
157somatic hypermutation of immunoglobulin genes (GO:0016446)2.43064046
158mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.41587510
159mitochondrial respiratory chain complex I assembly (GO:0032981)2.41587510
160NADH dehydrogenase complex assembly (GO:0010257)2.41587510
161neuron recognition (GO:0008038)2.39912246
162protein complex biogenesis (GO:0070271)2.38761672
163positive regulation of mitochondrial fission (GO:0090141)2.38494757
164establishment of protein localization to mitochondrial membrane (GO:0090151)2.37546724
165protein localization to synapse (GO:0035418)2.36352680
166DNA demethylation (GO:0080111)2.35401509
167hippocampus development (GO:0021766)2.34409782
168cell migration in hindbrain (GO:0021535)2.33730422
169negative regulation of DNA-dependent DNA replication (GO:2000104)2.33497746
170mitochondrial respiratory chain complex assembly (GO:0033108)2.33340589
171base-excision repair, AP site formation (GO:0006285)2.33266072
172glial cell proliferation (GO:0014009)2.33112917
173ubiquinone biosynthetic process (GO:0006744)2.32106012
174microtubule polymerization or depolymerization (GO:0031109)2.30734896
175termination of RNA polymerase III transcription (GO:0006386)2.29695547
176transcription elongation from RNA polymerase III promoter (GO:0006385)2.29695547
177dendritic spine morphogenesis (GO:0060997)2.29248689
178cell differentiation in spinal cord (GO:0021515)2.27151462
179histone exchange (GO:0043486)2.26383129
180mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.26256937
181detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.24822468
182spinal cord motor neuron differentiation (GO:0021522)2.22821618
183metallo-sulfur cluster assembly (GO:0031163)2.22682708
184iron-sulfur cluster assembly (GO:0016226)2.22682708
185proteasome assembly (GO:0043248)2.21301670
186platelet dense granule organization (GO:0060155)2.20158818
187thalamus development (GO:0021794)2.20078737
188maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.17944755
189DNA ligation (GO:0006266)2.17728783
190establishment of integrated proviral latency (GO:0075713)2.16471897

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.71511974
2TP63_19390658_ChIP-ChIP_HaCaT_Human4.04951121
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.74313193
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.74313193
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.74313193
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.68801997
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.48621472
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.41907851
9EZH2_22144423_ChIP-Seq_EOC_Human3.41225454
10ZNF274_21170338_ChIP-Seq_K562_Hela3.38324034
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.09390802
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.07993423
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.93570409
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.92025408
15IGF1R_20145208_ChIP-Seq_DFB_Human2.88477270
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.65191066
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.57862567
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.49982143
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.49442944
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.48664746
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.44740468
22GBX2_23144817_ChIP-Seq_PC3_Human2.36610173
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.30952663
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.27448591
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.26164148
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21906550
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.17286864
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.13384176
29EWS_26573619_Chip-Seq_HEK293_Human2.09577951
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.07863443
31NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.06857893
32FUS_26573619_Chip-Seq_HEK293_Human2.06223013
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.05981932
34CREB1_15753290_ChIP-ChIP_HEK293T_Human2.03506305
35ZFP57_27257070_Chip-Seq_ESCs_Mouse2.03238656
36ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.02768411
37SOX2_18555785_ChIP-Seq_MESCs_Mouse1.96604941
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94814518
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.94102553
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93115966
41TAF15_26573619_Chip-Seq_HEK293_Human1.91620861
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.91231296
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.88358653
44SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.85418775
45XRN2_22483619_ChIP-Seq_HELA_Human1.84970618
46SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.84671985
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.84394083
48JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.84244389
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84095776
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81453164
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.77797946
52VDR_22108803_ChIP-Seq_LS180_Human1.76290810
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71872798
54GABP_17652178_ChIP-ChIP_JURKAT_Human1.71674214
55POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.70106212
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70058790
57TCF3_18692474_ChIP-Seq_MESCs_Mouse1.69634463
58TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68536905
59P300_19829295_ChIP-Seq_ESCs_Human1.67920236
60BP1_19119308_ChIP-ChIP_Hs578T_Human1.67425828
61TCF3_18692474_ChIP-Seq_MEFs_Mouse1.67248580
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.63872587
63* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.63107200
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62882310
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62636066
66IRF1_19129219_ChIP-ChIP_H3396_Human1.61475692
67TTF2_22483619_ChIP-Seq_HELA_Human1.61087320
68CIITA_25753668_ChIP-Seq_RAJI_Human1.59375487
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.57384129
70KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.54684845
71FOXP3_21729870_ChIP-Seq_TREG_Human1.54624026
72* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53519387
73NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.53296841
74* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53015073
75* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46809387
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45680363
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44815805
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44153880
79NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.41859756
80E2F1_21310950_ChIP-Seq_MCF-7_Human1.40625667
81E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37895699
82BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36334574
83REST_21632747_ChIP-Seq_MESCs_Mouse1.36296688
84EZH2_27304074_Chip-Seq_ESCs_Mouse1.36210628
85NANOG_16153702_ChIP-ChIP_HESCs_Human1.34847294
86GABP_19822575_ChIP-Seq_HepG2_Human1.34429465
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31664030
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31485337
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31391087
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31391087
91VDR_23849224_ChIP-Seq_CD4+_Human1.29612899
92NANOG_21062744_ChIP-ChIP_HESCs_Human1.28960527
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28061801
94SOX2_16153702_ChIP-ChIP_HESCs_Human1.27930599
95MYC_22102868_ChIP-Seq_BL_Human1.27920125
96AR_21909140_ChIP-Seq_LNCAP_Human1.25950386
97POU5F1_16518401_ChIP-PET_MESCs_Mouse1.23758888
98ELF1_17652178_ChIP-ChIP_JURKAT_Human1.22556215
99NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.22011754
100SALL1_21062744_ChIP-ChIP_HESCs_Human1.21841765
101KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20781099
102ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19307034
103CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18905802
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18812916
105FLI1_27457419_Chip-Seq_LIVER_Mouse1.16691244
106ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16680684
107PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16512306
108KDM5A_27292631_Chip-Seq_BREAST_Human1.16462640
109REST_18959480_ChIP-ChIP_MESCs_Mouse1.15702687
110HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15191274
111SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.12600748
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11729864
113ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11590929
114DCP1A_22483619_ChIP-Seq_HELA_Human1.11498063
115SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11099002
116TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.11066472
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09653323
118SMAD3_21741376_ChIP-Seq_EPCs_Human1.09458308
119PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08070950
120POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.07342046
121SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07097783
122FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06015303
123EED_16625203_ChIP-ChIP_MESCs_Mouse1.05242101
124UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02908198
125PIAS1_25552417_ChIP-Seq_VCAP_Human1.02693404
126TP53_22573176_ChIP-Seq_HFKS_Human1.02614043
127E2F1_17053090_ChIP-ChIP_MCF-7_Human1.02229091
128AR_25329375_ChIP-Seq_VCAP_Human1.02119141
129MYC_18940864_ChIP-ChIP_HL60_Human1.01579131
130SMAD4_21799915_ChIP-Seq_A2780_Human1.00858256
131TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00603571
132STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99925254
133ELK1_19687146_ChIP-ChIP_HELA_Human0.99577400
134CBP_20019798_ChIP-Seq_JUKART_Human0.99080693
135IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99080693
136ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98102926
137SOX2_18692474_ChIP-Seq_MESCs_Mouse0.98054130
138STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97793861
139SOX2_18692474_ChIP-Seq_MEFs_Mouse0.97588422
140ER_23166858_ChIP-Seq_MCF-7_Human0.97449957
141RNF2_27304074_Chip-Seq_NSC_Mouse0.96195639
142OCT4_18692474_ChIP-Seq_MEFs_Mouse0.95686880
143PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.95372201
144SRF_21415370_ChIP-Seq_HL-1_Mouse0.94626782
145OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94435155
146EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93979272
147* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93366859
148SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93209618
149AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92871526
150E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92470211
151SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91370325
152KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91341131
153PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90612014
154ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90452901
155* RUNX2_22187159_ChIP-Seq_PCA_Human0.89914474
156FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.89472611
157KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.89387314
158TBX3_20139965_ChIP-Seq_ESCs_Mouse0.88355716
159POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.88256123
160BCAT_22108803_ChIP-Seq_LS180_Human0.88026581
161RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85356472

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.49994073
2MP0003122_maternal_imprinting3.30170851
3MP0008057_abnormal_DNA_replication3.20799173
4MP0003121_genomic_imprinting3.08116856
5MP0003123_paternal_imprinting2.93874098
6MP0003890_abnormal_embryonic-extraembry2.84993262
7MP0003880_abnormal_central_pattern2.84384128
8MP0004957_abnormal_blastocyst_morpholog2.82221267
9MP0001529_abnormal_vocalization2.74635145
10MP0010030_abnormal_orbit_morphology2.69612777
11MP0005499_abnormal_olfactory_system2.57728733
12MP0005394_taste/olfaction_phenotype2.57728733
13MP0003111_abnormal_nucleus_morphology2.51841490
14MP0010094_abnormal_chromosome_stability2.43735740
15MP0003077_abnormal_cell_cycle2.31441799
16MP0002653_abnormal_ependyma_morphology2.22529294
17MP0008789_abnormal_olfactory_epithelium2.15986149
18MP0000049_abnormal_middle_ear2.15836702
19MP0003693_abnormal_embryo_hatching2.09902775
20MP0006276_abnormal_autonomic_nervous2.06804442
21MP0003315_abnormal_perineum_morphology2.02019713
22MP0003119_abnormal_digestive_system1.99132982
23MP0004264_abnormal_extraembryonic_tissu1.97963767
24MP0008058_abnormal_DNA_repair1.95676992
25MP0003011_delayed_dark_adaptation1.92237615
26MP0003938_abnormal_ear_development1.89637864
27MP0008932_abnormal_embryonic_tissue1.81606145
28MP0008007_abnormal_cellular_replicative1.80828388
29MP0001293_anophthalmia1.79697072
30MP0005423_abnormal_somatic_nervous1.74993438
31MP0001672_abnormal_embryogenesis/_devel1.74113699
32MP0005380_embryogenesis_phenotype1.74113699
33MP0001984_abnormal_olfaction1.70542638
34MP0004133_heterotaxia1.68923571
35MP0003787_abnormal_imprinting1.68438695
36MP0002085_abnormal_embryonic_tissue1.62538327
37MP0000678_abnormal_parathyroid_gland1.62406648
38MP0000350_abnormal_cell_proliferation1.61837980
39MP0002822_catalepsy1.61610298
40MP0003136_yellow_coat_color1.60294422
41MP0002249_abnormal_larynx_morphology1.58389275
42MP0002088_abnormal_embryonic_growth/wei1.57060458
43MP0003984_embryonic_growth_retardation1.56114832
44MP0002234_abnormal_pharynx_morphology1.55873505
45MP0003942_abnormal_urinary_system1.54384779
46MP0002736_abnormal_nociception_after1.52785918
47MP0002932_abnormal_joint_morphology1.51941981
48MP0004270_analgesia1.51656995
49MP0005075_abnormal_melanosome_morpholog1.50572258
50MP0001188_hyperpigmentation1.49112561
51MP0002938_white_spotting1.47661237
52MP0003937_abnormal_limbs/digits/tail_de1.47204814
53MP0002084_abnormal_developmental_patter1.47087713
54MP0002233_abnormal_nose_morphology1.43619697
55MP0000537_abnormal_urethra_morphology1.43456405
56MP0003755_abnormal_palate_morphology1.42897414
57MP0002751_abnormal_autonomic_nervous1.42867389
58MP0001486_abnormal_startle_reflex1.42432874
59MP0003385_abnormal_body_wall1.42354732
60MP0004197_abnormal_fetal_growth/weight/1.41550949
61MP0008877_abnormal_DNA_methylation1.40337514
62MP0001485_abnormal_pinna_reflex1.39274438
63MP0003935_abnormal_craniofacial_develop1.38585072
64MP0001730_embryonic_growth_arrest1.38518627
65MP0008995_early_reproductive_senescence1.38204215
66MP0002638_abnormal_pupillary_reflex1.31435494
67MP0005645_abnormal_hypothalamus_physiol1.30856553
68MP0004859_abnormal_synaptic_plasticity1.30224773
69MP0001697_abnormal_embryo_size1.29340819
70MP0009053_abnormal_anal_canal1.29261157
71MP0000372_irregular_coat_pigmentation1.28835018
72MP0001968_abnormal_touch/_nociception1.27759153
73MP0001286_abnormal_eye_development1.27708774
74MP0005253_abnormal_eye_physiology1.26920720
75MP0005257_abnormal_intraocular_pressure1.26108899
76MP0002114_abnormal_axial_skeleton1.25840137
77MP0003861_abnormal_nervous_system1.25230885
78MP0009745_abnormal_behavioral_response1.24736943
79MP0002092_abnormal_eye_morphology1.23096428
80MP0002734_abnormal_mechanical_nocicepti1.22476710
81MP0003786_premature_aging1.22392238
82MP0002116_abnormal_craniofacial_bone1.22112386
83MP0004142_abnormal_muscle_tone1.21999714
84MP0005551_abnormal_eye_electrophysiolog1.20554385
85MP0005646_abnormal_pituitary_gland1.19978700
86MP0002184_abnormal_innervation1.19763200
87MP0000428_abnormal_craniofacial_morphol1.19443296
88MP0002557_abnormal_social/conspecific_i1.18942768
89MP0003635_abnormal_synaptic_transmissio1.18724135
90MP0002735_abnormal_chemical_nociception1.18318305
91MP0000432_abnormal_head_morphology1.18186901
92MP0002127_abnormal_cardiovascular_syste1.17372447
93MP0005248_abnormal_Harderian_gland1.16149738
94MP0002086_abnormal_extraembryonic_tissu1.15544832
95MP0009250_abnormal_appendicular_skeleto1.15496320
96MP0002572_abnormal_emotion/affect_behav1.15465314
97MP0005367_renal/urinary_system_phenotyp1.12530939
98MP0000516_abnormal_urinary_system1.12530939
99MP0002272_abnormal_nervous_system1.12101158
100MP0009703_decreased_birth_body1.11766728
101MP0002752_abnormal_somatic_nervous1.08743437
102MP0000762_abnormal_tongue_morphology1.08363659
103MP0002080_prenatal_lethality1.05959637
104MP0002063_abnormal_learning/memory/cond1.05826743
105MP0000955_abnormal_spinal_cord1.05591316
106MP0006035_abnormal_mitochondrial_morpho1.04375783
107MP0000566_synostosis1.04147504
108MP0001849_ear_inflammation1.03055905
109MP0005187_abnormal_penis_morphology1.01956657
110MP0003718_maternal_effect1.00688858
111MP0002111_abnormal_tail_morphology1.00644652
112MP0002282_abnormal_trachea_morphology1.00588052
113MP0004742_abnormal_vestibular_system1.00152418
114MP0001299_abnormal_eye_distance/0.99202093
115MP0000631_abnormal_neuroendocrine_gland0.98164202
116MP0002152_abnormal_brain_morphology0.97174462
117MP0010352_gastrointestinal_tract_polyps0.96861587
118MP0002081_perinatal_lethality0.96692452
119MP0002396_abnormal_hematopoietic_system0.96491758
120MP0004811_abnormal_neuron_physiology0.95302144
121MP0004858_abnormal_nervous_system0.94427992
122MP0002067_abnormal_sensory_capabilities0.94315408
123MP0002102_abnormal_ear_morphology0.93205697
124MP0003567_abnormal_fetal_cardiomyocyte0.92949002
125MP0000647_abnormal_sebaceous_gland0.92895097
126MP0000313_abnormal_cell_death0.92377334
127MP0000026_abnormal_inner_ear0.92250380
128MP0002882_abnormal_neuron_morphology0.92145908
129MP0005391_vision/eye_phenotype0.91432227
130MP0009672_abnormal_birth_weight0.91425950
131MP0009046_muscle_twitch0.90525203
132MP0002160_abnormal_reproductive_system0.88841695
133MP0002210_abnormal_sex_determination0.87801998
134MP0001905_abnormal_dopamine_level0.87305573
135MP0005084_abnormal_gallbladder_morpholo0.85728456
136MP0000778_abnormal_nervous_system0.85427910
137MP0002697_abnormal_eye_size0.84469567
138MP0002277_abnormal_respiratory_mucosa0.83867461
139MP0004145_abnormal_muscle_electrophysio0.83675631
140MP0002064_seizures0.82647989
141MP0001145_abnormal_male_reproductive0.81771760
142MP0003115_abnormal_respiratory_system0.80637611
143MP0003698_abnormal_male_reproductive0.80180606
144MP0003941_abnormal_skin_development0.79931385
145MP0004924_abnormal_behavior0.79518323
146MP0005386_behavior/neurological_phenoty0.79518323
147MP0005195_abnormal_posterior_eye0.79005061
148MP0004885_abnormal_endolymph0.77679561
149MP0000534_abnormal_ureter_morphology0.77321984
150MP0005508_abnormal_skeleton_morphology0.73374955
151MP0002925_abnormal_cardiovascular_devel0.72643383
152MP0002109_abnormal_limb_morphology0.72215466
153MP0000490_abnormal_crypts_of0.67523231
154MP0002177_abnormal_outer_ear0.65266373
155MP0006072_abnormal_retinal_apoptosis0.64112763
156MP0003283_abnormal_digestive_organ0.63068059

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)5.17881710
2Hepatoblastoma (HP:0002884)4.48245995
3Nephroblastoma (Wilms tumor) (HP:0002667)3.92779476
4Embryonal renal neoplasm (HP:0011794)3.72917501
5Rib fusion (HP:0000902)3.56074041
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.52006531
7Ependymoma (HP:0002888)3.49578935
8Abnormal lung lobation (HP:0002101)3.32520616
9Hypochromic microcytic anemia (HP:0004840)3.23473056
10Chromsome breakage (HP:0040012)3.14752076
11Supernumerary spleens (HP:0009799)3.03837033
12Renal duplication (HP:0000075)2.97907808
13Meckel diverticulum (HP:0002245)2.92977323
14Bifid tongue (HP:0010297)2.87938104
15Rhabdomyosarcoma (HP:0002859)2.85960399
16Intestinal atresia (HP:0011100)2.84595412
17Aplasia/Hypoplasia of the sternum (HP:0006714)2.84032803
18Neoplasm of striated muscle (HP:0009728)2.83841367
19Pancreatic cysts (HP:0001737)2.82565719
20Medulloblastoma (HP:0002885)2.81514356
21Abnormality of the ileum (HP:0001549)2.79272061
22Septo-optic dysplasia (HP:0100842)2.79155449
23True hermaphroditism (HP:0010459)2.75942897
24Pancreatic fibrosis (HP:0100732)2.67891450
25Patellar aplasia (HP:0006443)2.66132459
26Multiple enchondromatosis (HP:0005701)2.64287491
27Shawl scrotum (HP:0000049)2.62695436
28Abnormality of the lower motor neuron (HP:0002366)2.57845823
29Aplasia/Hypoplasia of the uvula (HP:0010293)2.54570138
30Aplasia/Hypoplasia of the patella (HP:0006498)2.54296141
31Abnormality of the phalanges of the hallux (HP:0010057)2.50930043
32Rectal fistula (HP:0100590)2.50780799
33Rectovaginal fistula (HP:0000143)2.50780799
34Impulsivity (HP:0100710)2.50358208
35Astrocytoma (HP:0009592)2.50236369
36Abnormality of the astrocytes (HP:0100707)2.50236369
37Cortical dysplasia (HP:0002539)2.47979021
38Pendular nystagmus (HP:0012043)2.46915023
39Atresia of the external auditory canal (HP:0000413)2.45911219
40Partial duplication of thumb phalanx (HP:0009944)2.42660722
41Partial duplication of the phalanx of hand (HP:0009999)2.42135929
42Molar tooth sign on MRI (HP:0002419)2.40223284
43Abnormality of midbrain morphology (HP:0002418)2.40223284
44Oligodactyly (hands) (HP:0001180)2.39257642
45Nephronophthisis (HP:0000090)2.38475957
46Optic nerve hypoplasia (HP:0000609)2.38348981
47Abnormal number of incisors (HP:0011064)2.37604857
48Intestinal fistula (HP:0100819)2.36961514
49Lissencephaly (HP:0001339)2.34753568
50Embryonal neoplasm (HP:0002898)2.32526357
51Aplasia/hypoplasia of the humerus (HP:0006507)2.31276724
52Facial cleft (HP:0002006)2.30223007
53Preauricular skin tag (HP:0000384)2.28874689
54Medial flaring of the eyebrow (HP:0010747)2.28033367
55Gait imbalance (HP:0002141)2.26771506
56Hyperglycinemia (HP:0002154)2.25415031
57Supernumerary ribs (HP:0005815)2.22932107
58Acute necrotizing encephalopathy (HP:0006965)2.21822315
59Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.21772752
60Retinal dysplasia (HP:0007973)2.19474258
61Anophthalmia (HP:0000528)2.18211679
62Diastasis recti (HP:0001540)2.18178435
63Anencephaly (HP:0002323)2.17424645
64Short 5th finger (HP:0009237)2.17394256
65Methylmalonic acidemia (HP:0002912)2.17134113
66Duodenal stenosis (HP:0100867)2.16929064
67Small intestinal stenosis (HP:0012848)2.16929064
68Preaxial hand polydactyly (HP:0001177)2.16867508
69Supernumerary bones of the axial skeleton (HP:0009144)2.16647171
70Glioma (HP:0009733)2.14918224
71Colon cancer (HP:0003003)2.13494599
72Renal hypoplasia (HP:0000089)2.12229437
73Volvulus (HP:0002580)2.12221084
74Preauricular pit (HP:0004467)2.11896238
75Periauricular skin pits (HP:0100277)2.11896238
76Acute encephalopathy (HP:0006846)2.11467813
77Absent septum pellucidum (HP:0001331)2.11002869
78Vaginal atresia (HP:0000148)2.09858001
79Increased nuchal translucency (HP:0010880)2.09792102
80Anomalous pulmonary venous return (HP:0010772)2.09762405
81Genital tract atresia (HP:0001827)2.09496275
82Congenital primary aphakia (HP:0007707)2.07835655
83Abnormality of the renal medulla (HP:0100957)2.06858785
84Short humerus (HP:0005792)2.06167878
85Skin tags (HP:0010609)2.06089509
86Aqueductal stenosis (HP:0002410)2.06038855
87Abnormality of the intervertebral disk (HP:0005108)2.05696851
88Trismus (HP:0000211)2.05334695
89High anterior hairline (HP:0009890)2.04193024
90Abnormality of the labia minora (HP:0012880)2.03944516
91Abnormality of chromosome segregation (HP:0002916)2.03589834
92Selective tooth agenesis (HP:0001592)2.03459623
93Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.02943441
94Oligodactyly (HP:0012165)2.02170896
95Fused cervical vertebrae (HP:0002949)2.01289152
96Abnormality of the preputium (HP:0100587)2.00946978
97Labial hypoplasia (HP:0000066)1.99141523
98Hypoplastic female external genitalia (HP:0012815)1.97664286
99Sclerocornea (HP:0000647)1.97497503
100Broad-based gait (HP:0002136)1.97184740
101Nephrogenic diabetes insipidus (HP:0009806)1.97121791
102Short 4th metacarpal (HP:0010044)1.96408088
103Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.96408088
104Esophageal atresia (HP:0002032)1.96018610
105Gastrointestinal atresia (HP:0002589)1.95822583
106Vaginal fistula (HP:0004320)1.95481269
107Aplastic anemia (HP:0001915)1.95278589
108Duplication of thumb phalanx (HP:0009942)1.94914502
109Limb dystonia (HP:0002451)1.94825270
110Triphalangeal thumb (HP:0001199)1.94340100
111Breast hypoplasia (HP:0003187)1.93697589
112Congenital diaphragmatic hernia (HP:0000776)1.92944343
113Drooling (HP:0002307)1.92209257
114Broad alveolar ridges (HP:0000187)1.91937736
115Amyotrophic lateral sclerosis (HP:0007354)1.91606008
116Abnormality of the duodenum (HP:0002246)1.91036647
117Progressive macrocephaly (HP:0004481)1.90974964
118Abnormality of the septum pellucidum (HP:0007375)1.90860661
119Pachygyria (HP:0001302)1.90762137
120Postaxial hand polydactyly (HP:0001162)1.90498959
121Atrophy/Degeneration involving motor neurons (HP:0007373)1.90377679
122Abnormality of the pulmonary veins (HP:0011718)1.90259099
123Cystic liver disease (HP:0006706)1.90061526
124Hyperglycinuria (HP:0003108)1.88902100
125Optic nerve coloboma (HP:0000588)1.86677667
126Malignant neoplasm of the central nervous system (HP:0100836)1.86505316
127Abnormal mitochondria in muscle tissue (HP:0008316)1.86460342
128Generalized hypotonia (HP:0001290)1.86155073
129Dandy-Walker malformation (HP:0001305)1.85686103
130Hypothermia (HP:0002045)1.85613124
131Polyphagia (HP:0002591)1.83889727
132Nasolacrimal duct obstruction (HP:0000579)1.83276012
133Specific learning disability (HP:0001328)1.81822868
134Birth length less than 3rd percentile (HP:0003561)1.80767212
135Abnormality of the lacrimal duct (HP:0011481)1.80570455
136Aplasia/Hypoplasia of the tongue (HP:0010295)1.80140771
137Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80071359
138Abnormality of serine family amino acid metabolism (HP:0010894)1.79080057
139Abnormality of glycine metabolism (HP:0010895)1.79080057
140Missing ribs (HP:0000921)1.77797442
141Short middle phalanx of the 5th finger (HP:0004220)1.77267908
142Mitochondrial inheritance (HP:0001427)1.77264090
143Ectopic kidney (HP:0000086)1.76484595
144Abnormal hair whorl (HP:0010721)1.75507414
145Absent radius (HP:0003974)1.75324598
146Bile duct proliferation (HP:0001408)1.75124372
147Abnormal biliary tract physiology (HP:0012439)1.75124372
148Abnormality of abdominal situs (HP:0011620)1.74268775
149Abdominal situs inversus (HP:0003363)1.74268775
150Hemivertebrae (HP:0002937)1.74255655
151Postaxial foot polydactyly (HP:0001830)1.73669456
152Microvesicular hepatic steatosis (HP:0001414)1.73544233
153Hypoplasia of the fovea (HP:0007750)1.72850277
154Aplasia/Hypoplasia of the fovea (HP:0008060)1.72850277
155Aplasia/Hypoplasia involving the musculature (HP:0001460)1.72778096
156Small hand (HP:0200055)1.72754867
157Broad foot (HP:0001769)1.72415479
158Sleep apnea (HP:0010535)1.72292094
159Sloping forehead (HP:0000340)1.71527098
160Growth hormone deficiency (HP:0000824)1.71451060
161Type II lissencephaly (HP:0007260)1.71406325
162Abnormality of the nasolacrimal system (HP:0000614)1.71313219
163Abnormality of chromosome stability (HP:0003220)1.69558585
164Ectopic anus (HP:0004397)1.68383023
165Aplasia/Hypoplasia of the brainstem (HP:0007362)1.68228960
166Hypoplasia of the brainstem (HP:0002365)1.68228960
167Renal cortical cysts (HP:0000803)1.67730739
168Aplasia involving forearm bones (HP:0009822)1.67384027
169Absent forearm bone (HP:0003953)1.67384027
170Abnormality of the anterior horn cell (HP:0006802)1.67272648
171Micropenis (HP:0000054)1.65508466
172Excessive salivation (HP:0003781)1.65481963
173Hypoplastic pelvis (HP:0008839)1.64790962
174Abnormality of the parathyroid morphology (HP:0011766)1.64641415
175Poor suck (HP:0002033)1.64417224
176Carpal bone hypoplasia (HP:0001498)1.63844053
177Scrotal hypoplasia (HP:0000046)1.63708406
178Occipital encephalocele (HP:0002085)1.63200861
179Thyroid-stimulating hormone excess (HP:0002925)1.63088246

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.38574014
2TRIM283.63037383
3WNK33.35529893
4SRPK13.13070472
5CDC73.00091856
6BUB12.98957177
7TNIK2.67186051
8TTK2.63693721
9MAP4K22.59588959
10MKNK12.53388130
11MAP3K42.46480891
12GRK52.35040148
13CDK72.23726905
14MAP2K72.22887809
15MKNK22.16815377
16GRK62.16309753
17MAP3K102.07233937
18WEE12.05493166
19NUAK11.94949022
20VRK21.93764998
21CHEK21.85326955
22PLK11.81437020
23ADRBK21.80529892
24GRK11.71166073
25BMPR1B1.70482320
26DYRK31.67737416
27NEK21.59130687
28AKT31.59072755
29TYRO31.57472447
30BRD41.51882221
31CSNK1G21.49652593
32DYRK21.49413685
33ZAK1.48022598
34CSNK1G31.44107882
35CDK191.43038174
36ERN11.40549111
37FRK1.40345997
38FGFR21.38324137
39CSNK1G11.37269427
40PAK41.37183002
41LATS21.36743150
42RPS6KA41.35413824
43BCKDK1.33105494
44CHEK11.31520771
45PLK41.28486248
46MARK11.24926903
47CSF1R1.24360234
48MINK11.20207765
49PLK21.19257865
50ATR1.18841441
51MAPK71.18741067
52CSNK1A1L1.18541786
53EPHA41.16438072
54EIF2AK21.15906972
55MATK1.15457624
56INSRR1.14275749
57PASK1.11752562
58AURKA1.10420975
59PLK31.09178626
60PAK31.08164228
61TLK11.06531909
62CAMK41.05255106
63AURKB1.05156935
64EPHB21.01780382
65CASK1.01554377
66PINK11.00611719
67ERBB31.00028748
68EIF2AK10.96937701
69PNCK0.95805719
70CDK80.94827579
71GRK70.94309960
72* CDK20.93953612
73TSSK60.93616866
74ATM0.92402430
75STK100.89815472
76STK38L0.89503370
77MARK20.88799752
78ACVR1B0.87931077
79CDK40.85976020
80STK160.84949137
81TGFBR20.83983224
82PRKCG0.83462581
83OXSR10.82842065
84SIK30.82385271
85WNK10.82301074
86YES10.81047336
87NME10.80331387
88RPS6KB20.80186132
89ADRBK10.79916118
90VRK10.78440678
91PRKCI0.77427300
92TGFBR10.76332904
93CDK10.76094114
94UHMK10.74265619
95TAF10.70900861
96MTOR0.70884793
97AKT20.70582082
98ICK0.68882145
99PRKCE0.68016540
100MAPK130.67809509
101BRSK10.67786387
102BRSK20.67529124
103EPHA20.67236481
104FER0.66129370
105MAP2K40.65464246
106PKN10.65000250
107CDK30.64683656
108CCNB10.58642552
109DYRK1A0.57778431
110SIK20.56560358
111HIPK20.56410470
112PRPF4B0.53575266
113* CSNK1E0.52723185
114EPHA30.52430852
115PHKG10.49570721
116PHKG20.49570721
117BCR0.49338315
118NTRK20.49183490
119CSNK2A10.49160608
120WNK40.48179966
121TAOK20.48101847
122DYRK1B0.47775167
123DAPK20.47613491
124PAK10.46399639
125CSNK1A10.45386741
126MAPK140.45228387
127MAP2K60.44285743
128CSNK2A20.42644772
129* GSK3B0.41058850
130FLT30.40813136
131PRKAA10.39800545
132CDK180.39246667
133CDK11A0.39116038
134CAMK10.39060075
135MAPK150.38958422
136CSNK1D0.38083262
137ERBB20.37663048
138PAK60.37617411
139MOS0.37615293
140SGK2230.36152886
141SGK4940.36152886
142RPS6KA50.35908479
143NEK10.35459896
144PRKDC0.35445503
145CDK50.35357540
146PBK0.35114762
147FGFR10.35083334
148CDK150.34951649
149STK40.32778341
150AKT10.32486604
151MAPK90.31576151
152ALK0.29499839
153CDK140.28091350

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.86797306
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.86203432
3Mismatch repair_Homo sapiens_hsa034303.58281569
4Spliceosome_Homo sapiens_hsa030403.52942669
5RNA transport_Homo sapiens_hsa030133.21018729
6Ribosome_Homo sapiens_hsa030102.99628929
7Cell cycle_Homo sapiens_hsa041102.90133811
8RNA polymerase_Homo sapiens_hsa030202.83915192
9Base excision repair_Homo sapiens_hsa034102.83614837
10Homologous recombination_Homo sapiens_hsa034402.80165521
11mRNA surveillance pathway_Homo sapiens_hsa030152.76686725
12Fanconi anemia pathway_Homo sapiens_hsa034602.71844918
13Nucleotide excision repair_Homo sapiens_hsa034202.40732452
14Nicotine addiction_Homo sapiens_hsa050332.39783911
15Oxidative phosphorylation_Homo sapiens_hsa001902.25763775
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.19927126
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.19245023
18RNA degradation_Homo sapiens_hsa030182.19092881
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.09809352
20Vitamin B6 metabolism_Homo sapiens_hsa007502.08109333
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.03101183
22Basal transcription factors_Homo sapiens_hsa030222.02767702
23Basal cell carcinoma_Homo sapiens_hsa052171.98759381
24Steroid biosynthesis_Homo sapiens_hsa001001.97539061
25One carbon pool by folate_Homo sapiens_hsa006701.89141682
26Pyrimidine metabolism_Homo sapiens_hsa002401.87973539
27Proteasome_Homo sapiens_hsa030501.72087012
28Hedgehog signaling pathway_Homo sapiens_hsa043401.66088768
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.65807878
30Propanoate metabolism_Homo sapiens_hsa006401.63685488
31Butanoate metabolism_Homo sapiens_hsa006501.61841342
32Non-homologous end-joining_Homo sapiens_hsa034501.61219348
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.56484116
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.50321092
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49219948
36Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.46040291
37Fatty acid elongation_Homo sapiens_hsa000621.35268350
38Thyroid cancer_Homo sapiens_hsa052161.33415529
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33014650
40Hippo signaling pathway_Homo sapiens_hsa043901.29797394
41GABAergic synapse_Homo sapiens_hsa047271.26584360
42p53 signaling pathway_Homo sapiens_hsa041151.24276462
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.22022617
44Alzheimers disease_Homo sapiens_hsa050101.20110075
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16933139
46Oocyte meiosis_Homo sapiens_hsa041141.16807796
47Wnt signaling pathway_Homo sapiens_hsa043101.13474846
48MicroRNAs in cancer_Homo sapiens_hsa052061.11480030
49Arachidonic acid metabolism_Homo sapiens_hsa005901.10496874
50Fructose and mannose metabolism_Homo sapiens_hsa000511.05407472
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04111365
52Purine metabolism_Homo sapiens_hsa002301.01923673
53Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00035952
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97764626
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.96706953
56Regulation of autophagy_Homo sapiens_hsa041400.95639592
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93976616
58Notch signaling pathway_Homo sapiens_hsa043300.92275419
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87579123
60Peroxisome_Homo sapiens_hsa041460.85434418
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.84865301
62Morphine addiction_Homo sapiens_hsa050320.84656627
63Circadian entrainment_Homo sapiens_hsa047130.81742980
64Glutamatergic synapse_Homo sapiens_hsa047240.81231568
65HTLV-I infection_Homo sapiens_hsa051660.80171618
66Colorectal cancer_Homo sapiens_hsa052100.79495528
67Pathways in cancer_Homo sapiens_hsa052000.77741394
68Dopaminergic synapse_Homo sapiens_hsa047280.76592593
69TGF-beta signaling pathway_Homo sapiens_hsa043500.76333043
70Epstein-Barr virus infection_Homo sapiens_hsa051690.76254027
71Pyruvate metabolism_Homo sapiens_hsa006200.75226946
72Galactose metabolism_Homo sapiens_hsa000520.75199905
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73609960
74Ether lipid metabolism_Homo sapiens_hsa005650.71274151
75beta-Alanine metabolism_Homo sapiens_hsa004100.70620452
76Fatty acid metabolism_Homo sapiens_hsa012120.69212088
77Olfactory transduction_Homo sapiens_hsa047400.68195493
78Tryptophan metabolism_Homo sapiens_hsa003800.67052274
79Cocaine addiction_Homo sapiens_hsa050300.66345275
80Axon guidance_Homo sapiens_hsa043600.66249938
81Linoleic acid metabolism_Homo sapiens_hsa005910.66218140
82Huntingtons disease_Homo sapiens_hsa050160.65561730
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64244133
84Biosynthesis of amino acids_Homo sapiens_hsa012300.63805953
85Nitrogen metabolism_Homo sapiens_hsa009100.62862331
86Herpes simplex infection_Homo sapiens_hsa051680.62369497
87Synaptic vesicle cycle_Homo sapiens_hsa047210.61390668
88mTOR signaling pathway_Homo sapiens_hsa041500.55843918
89Viral carcinogenesis_Homo sapiens_hsa052030.54941491
90Tight junction_Homo sapiens_hsa045300.54311896
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53400294
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53086469
93Endometrial cancer_Homo sapiens_hsa052130.52092161
94Bladder cancer_Homo sapiens_hsa052190.52023382
95Collecting duct acid secretion_Homo sapiens_hsa049660.51971471
96Adherens junction_Homo sapiens_hsa045200.50874161
97Phototransduction_Homo sapiens_hsa047440.48938867
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47288938
99Circadian rhythm_Homo sapiens_hsa047100.47284229
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47092704
101Melanoma_Homo sapiens_hsa052180.45962336
102Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45676127
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45646597
104Non-small cell lung cancer_Homo sapiens_hsa052230.45506671
105Sulfur relay system_Homo sapiens_hsa041220.44877337
106Amphetamine addiction_Homo sapiens_hsa050310.44601144
107Lysine degradation_Homo sapiens_hsa003100.44363765
108Acute myeloid leukemia_Homo sapiens_hsa052210.44027080
109Melanogenesis_Homo sapiens_hsa049160.41850532
110Small cell lung cancer_Homo sapiens_hsa052220.41723949
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41255143
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40204111
113Arginine and proline metabolism_Homo sapiens_hsa003300.40146100
114Prostate cancer_Homo sapiens_hsa052150.39990767
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.39101947
116Carbon metabolism_Homo sapiens_hsa012000.38540648
117Insulin secretion_Homo sapiens_hsa049110.38494464
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36641742
119Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35834075
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33750468
121Alcoholism_Homo sapiens_hsa050340.33020888
122Gap junction_Homo sapiens_hsa045400.32995478
123Proteoglycans in cancer_Homo sapiens_hsa052050.31356288
124Rap1 signaling pathway_Homo sapiens_hsa040150.29059998
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28849036
126Taste transduction_Homo sapiens_hsa047420.28621356
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.27780713
128Systemic lupus erythematosus_Homo sapiens_hsa053220.25232715
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.24493376
130Parkinsons disease_Homo sapiens_hsa050120.24462968
131Selenocompound metabolism_Homo sapiens_hsa004500.23066690
132Chronic myeloid leukemia_Homo sapiens_hsa052200.18830633
133Cardiac muscle contraction_Homo sapiens_hsa042600.18495563
134Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17966779
135AMPK signaling pathway_Homo sapiens_hsa041520.17566382
136Ovarian steroidogenesis_Homo sapiens_hsa049130.17296321
137Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.17157823
138Protein export_Homo sapiens_hsa030600.16498885
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.16057312
140Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.16045086
141Drug metabolism - other enzymes_Homo sapiens_hsa009830.15919394
142N-Glycan biosynthesis_Homo sapiens_hsa005100.14488998
143Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.14148230
144ErbB signaling pathway_Homo sapiens_hsa040120.13808968
145Longevity regulating pathway - mammal_Homo sapiens_hsa042110.12660709
146Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12635656
147Serotonergic synapse_Homo sapiens_hsa047260.10823784
148Metabolic pathways_Homo sapiens_hsa011000.09281575
149Ras signaling pathway_Homo sapiens_hsa040140.08577168
150Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.07959232

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