BRD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of gene silencing (GO:0060969)8.33583351
2fatty acid elongation (GO:0030497)8.22743846
3behavioral response to nicotine (GO:0035095)6.22351329
4skeletal muscle tissue regeneration (GO:0043403)6.17473839
5membrane tubulation (GO:0097320)5.88383487
6regulation of hippo signaling (GO:0035330)5.67963933
7intra-S DNA damage checkpoint (GO:0031573)5.51435761
8regulation of gene silencing (GO:0060968)5.21777829
9myoblast migration (GO:0051451)5.15072577
10macrophage activation involved in immune response (GO:0002281)4.98938435
11heart trabecula morphogenesis (GO:0061384)4.54196667
12nucleoside diphosphate catabolic process (GO:0009134)4.44643886
13nuclear pore complex assembly (GO:0051292)4.30757550
14microglial cell activation (GO:0001774)4.24036800
15cellular response to gamma radiation (GO:0071480)4.06092677
16positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)4.03968109
17nuclear pore organization (GO:0006999)3.97956081
18regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.95148229
19detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.90979882
20autophagic vacuole fusion (GO:0000046)3.87182123
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.84102130
22pre-miRNA processing (GO:0031054)3.83256401
23monoubiquitinated protein deubiquitination (GO:0035520)3.81705811
24tachykinin receptor signaling pathway (GO:0007217)3.81266538
25mitotic sister chromatid cohesion (GO:0007064)3.79243849
26trabecula morphogenesis (GO:0061383)3.77262504
27kinetochore organization (GO:0051383)3.64343910
28heterochromatin organization (GO:0070828)3.63586343
29phagocytosis, engulfment (GO:0006911)3.62665031
30long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.59238500
31negative regulation of striated muscle cell apoptotic process (GO:0010664)3.57448927
32growth hormone receptor signaling pathway (GO:0060396)3.54986201
33positive regulation of skeletal muscle tissue development (GO:0048643)3.50630028
34pore complex assembly (GO:0046931)3.50384919
35kinetochore assembly (GO:0051382)3.42736823
36cilium or flagellum-dependent cell motility (GO:0001539)3.41858938
37histone H3-K4 methylation (GO:0051568)3.41061015
38auditory receptor cell stereocilium organization (GO:0060088)3.40332336
39cell junction maintenance (GO:0034331)3.38984953
40indolalkylamine metabolic process (GO:0006586)3.38031545
41antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.37975863
42serotonin metabolic process (GO:0042428)3.32214192
43respiratory tube development (GO:0030323)3.31821957
44response to nitrosative stress (GO:0051409)3.23501955
45negative regulation of neurotransmitter secretion (GO:0046929)3.21498373
46protein localization to kinetochore (GO:0034501)3.20960780
47mitotic nuclear envelope disassembly (GO:0007077)3.18859578
48histone H3-K4 trimethylation (GO:0080182)3.17535212
49meiotic chromosome segregation (GO:0045132)3.16375897
50signal peptide processing (GO:0006465)3.14900163
51negative regulation of histone methylation (GO:0031061)3.14798396
52regulation of collateral sprouting (GO:0048670)3.13450260
53histone H3-K9 modification (GO:0061647)3.12901948
54fatty-acyl-CoA biosynthetic process (GO:0046949)3.12313894
55mitotic sister chromatid segregation (GO:0000070)3.11389182
56cellular response to growth hormone stimulus (GO:0071378)3.09095850
57macrophage chemotaxis (GO:0048246)3.07832774
58DNA replication checkpoint (GO:0000076)3.06604232
59defense response to Gram-negative bacterium (GO:0050829)3.05336322
60negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.02324737
61sister chromatid segregation (GO:0000819)3.00494571
62DNA unwinding involved in DNA replication (GO:0006268)3.00006096
63tryptophan catabolic process (GO:0006569)2.98132673
64indole-containing compound catabolic process (GO:0042436)2.98132673
65indolalkylamine catabolic process (GO:0046218)2.98132673
66bundle of His cell to Purkinje myocyte communication (GO:0086069)2.97241240
67regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.96692320
68chemokine-mediated signaling pathway (GO:0070098)2.95767842
69intracellular estrogen receptor signaling pathway (GO:0030520)2.95434135
70DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.93699027
71detection of mechanical stimulus (GO:0050982)2.92629852
72membrane disassembly (GO:0030397)2.92310536
73nuclear envelope disassembly (GO:0051081)2.92310536
74snRNA transcription (GO:0009301)2.92255582
75regulation of nuclear cell cycle DNA replication (GO:0033262)2.92025450
76synaptic vesicle docking involved in exocytosis (GO:0016081)2.91811268
77protein localization to chromosome, centromeric region (GO:0071459)2.91219313
78glucocorticoid receptor signaling pathway (GO:0042921)2.90771063
79negative regulation of mRNA processing (GO:0050686)2.88733490
80positive regulation of gene expression, epigenetic (GO:0045815)2.87924817
81hepatocyte apoptotic process (GO:0097284)2.87346850
82mitotic chromosome condensation (GO:0007076)2.86049614
83protein-DNA complex disassembly (GO:0032986)2.85008519
84nucleosome disassembly (GO:0006337)2.85008519
85detection of mechanical stimulus involved in sensory perception (GO:0050974)2.84970281
86mitotic metaphase plate congression (GO:0007080)2.84804609
87phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.83753065
88negative regulation of RNA splicing (GO:0033119)2.82764035
89cellular defense response (GO:0006968)2.81555245
90negative regulation of calcium ion transport into cytosol (GO:0010523)2.78457081
91organelle membrane fusion (GO:0090174)2.77588460
92regulation of interleukin-12 biosynthetic process (GO:0045075)2.75478288
93regulation of stem cell maintenance (GO:2000036)2.74202788
94regulation of histone H3-K9 methylation (GO:0051570)2.73522913
95regulation of RNA export from nucleus (GO:0046831)2.73514923
96mRNA stabilization (GO:0048255)2.73161419
97RNA stabilization (GO:0043489)2.73161419
98trophectodermal cell differentiation (GO:0001829)2.73068967
99positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.72380516
100positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.72380516
101positive regulation of mitotic sister chromatid separation (GO:1901970)2.72380516
102positive regulation of developmental pigmentation (GO:0048087)2.71928770
103positive regulation of chromosome segregation (GO:0051984)2.70515923
104metaphase plate congression (GO:0051310)2.69840371
105DNA damage response, signal transduction resulting in transcription (GO:0042772)2.69063112
106regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.68976359
107primary amino compound metabolic process (GO:1901160)2.68951851
108regulation of B cell receptor signaling pathway (GO:0050855)2.68704472
1093-UTR-mediated mRNA stabilization (GO:0070935)2.66425659
110DNA duplex unwinding (GO:0032508)2.65765885
111thioester biosynthetic process (GO:0035384)2.65336847
112acyl-CoA biosynthetic process (GO:0071616)2.65336847
113regulation of fibroblast migration (GO:0010762)2.64650101
114DNA geometric change (GO:0032392)2.63823527
115alternative mRNA splicing, via spliceosome (GO:0000380)2.62071197
116regulation of sister chromatid cohesion (GO:0007063)2.61613825
117regulation of acrosome reaction (GO:0060046)2.61452173
118regulation of histone H3-K4 methylation (GO:0051569)2.61063119
119response to pheromone (GO:0019236)2.60910765
120regulation of spindle organization (GO:0090224)2.60407401
121DNA replication initiation (GO:0006270)2.60201652
122negative regulation of mRNA metabolic process (GO:1903312)2.59735666
123regulation of posttranscriptional gene silencing (GO:0060147)2.59453096
124regulation of gene silencing by miRNA (GO:0060964)2.59453096
125regulation of gene silencing by RNA (GO:0060966)2.59453096
126antigen processing and presentation of endogenous antigen (GO:0019883)2.58539775
127regulation of double-strand break repair (GO:2000779)2.57879588
128histone lysine methylation (GO:0034968)2.57500296
129long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.57303341
130chromatin assembly (GO:0031497)2.56792931
131maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.56740947
132negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.56493659
133negative regulation of translation, ncRNA-mediated (GO:0040033)2.56493659
134regulation of translation, ncRNA-mediated (GO:0045974)2.56493659
135indole-containing compound metabolic process (GO:0042430)2.56320653
136negative regulation of autophagy (GO:0010507)2.55777714
137histone H3-K9 methylation (GO:0051567)2.55042728
138regulation of mitotic spindle organization (GO:0060236)2.55029475
139fatty-acyl-CoA metabolic process (GO:0035337)2.54095612
140positive regulation by host of viral transcription (GO:0043923)2.54066662
141dosage compensation (GO:0007549)2.53918800
142regulation of short-term neuronal synaptic plasticity (GO:0048172)2.52907455
143kynurenine metabolic process (GO:0070189)2.52420117
144regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.52399030
145histone methylation (GO:0016571)2.51401033
146* regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.50934787
147DNA strand elongation involved in DNA replication (GO:0006271)2.50209692
148positive regulation of DNA-dependent DNA replication (GO:2000105)2.49422603
149oxidative demethylation (GO:0070989)2.49291596
150sister chromatid cohesion (GO:0007062)2.49077614
151regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.48426661
152DNA alkylation (GO:0006305)2.48192774
153DNA methylation (GO:0006306)2.48192774
154paraxial mesoderm development (GO:0048339)2.47594148
155regulation of telomere maintenance via telomerase (GO:0032210)2.46918759
156cellular ketone body metabolic process (GO:0046950)2.46354377
157protein localization to chromosome (GO:0034502)2.46136058
158somatic hypermutation of immunoglobulin genes (GO:0016446)2.45982782
159somatic diversification of immune receptors via somatic mutation (GO:0002566)2.45982782
160regulation of striated muscle cell apoptotic process (GO:0010662)2.44706738
161telomere maintenance via semi-conservative replication (GO:0032201)2.44247918
162regulation of DNA endoreduplication (GO:0032875)2.44238356
163syncytium formation (GO:0006949)2.43440449
164protein K48-linked deubiquitination (GO:0071108)2.43317549
165corticosteroid receptor signaling pathway (GO:0031958)2.43257921
166righting reflex (GO:0060013)2.42645914
167reflex (GO:0060004)2.42175368
168regulation of gene expression by genetic imprinting (GO:0006349)2.41408238
169cytoplasmic mRNA processing body assembly (GO:0033962)2.41290480
170regulation of histone methylation (GO:0031060)2.40911802
171positive T cell selection (GO:0043368)2.40835924
172negative regulation of histone modification (GO:0031057)2.40721543
173attachment of spindle microtubules to kinetochore (GO:0008608)2.40610798
174ATP-dependent chromatin remodeling (GO:0043044)2.40185611
175acrosome reaction (GO:0007340)2.40132442
176DNA topological change (GO:0006265)2.39845533
177defense response to fungus (GO:0050832)2.39467542
178DNA strand elongation (GO:0022616)2.39304896
179RNA splicing, via transesterification reactions (GO:0000375)2.39166200
180peptidyl-lysine trimethylation (GO:0018023)2.39123084
181benzene-containing compound metabolic process (GO:0042537)2.38444723
182histone H2A acetylation (GO:0043968)2.37386181
183positive regulation of cell cycle checkpoint (GO:1901978)2.36851031
184mRNA splicing, via spliceosome (GO:0000398)2.35899691
185RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.35899691
186negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.35580573
187mRNA transport (GO:0051028)2.35484518
188negative regulation of chromatin modification (GO:1903309)2.35410412
189regulation of meiosis I (GO:0060631)2.35387941
190regulation of mRNA stability (GO:0043488)2.35291141
191regulation of chromatin silencing (GO:0031935)2.35139606
192establishment of chromosome localization (GO:0051303)2.34542121
193nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.33845137

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.88320211
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.07135392
3EZH2_22144423_ChIP-Seq_EOC_Human4.92760670
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.94959205
5TP63_19390658_ChIP-ChIP_HaCaT_Human3.78661796
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.63235022
7DROSHA_22980978_ChIP-Seq_HELA_Human3.53995403
8MYC_22102868_ChIP-Seq_BL_Human3.42487247
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.33513625
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.52507507
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.51589121
12VDR_22108803_ChIP-Seq_LS180_Human2.31960211
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.18904356
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.17265032
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.15324865
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.11274581
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.11274581
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.11274581
19VDR_21846776_ChIP-Seq_THP-1_Human2.09627862
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.05387721
21NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human2.03040197
22CIITA_25753668_ChIP-Seq_RAJI_Human2.00989679
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.00313788
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.00182105
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.99821276
26GBX2_23144817_ChIP-Seq_PC3_Human1.98147058
27TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.98020418
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.91116871
29TCF7_22412390_ChIP-Seq_EML_Mouse1.86096810
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.85977826
31SCL_19346495_ChIP-Seq_HPC-7_Human1.80800128
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.77698109
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.75384980
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.75271697
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.74222667
36SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.73044592
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70925667
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.70333189
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.64781473
40CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.64491315
41* REST_21632747_ChIP-Seq_MESCs_Mouse1.63032889
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.59914547
43SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.55939783
44* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.55658711
45JARID2_20064375_ChIP-Seq_MESCs_Mouse1.54302927
46* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.53964540
47IRF8_22096565_ChIP-ChIP_GC-B_Human1.53878228
48ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.53397877
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.53117756
50KDM2B_26808549_Chip-Seq_DND41_Human1.52113946
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.51956909
52CTNNB1_20460455_ChIP-Seq_HCT116_Human1.51031787
53* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50182170
54UTX_26944678_Chip-Seq_JUKART_Human1.49148397
55MAF_26560356_Chip-Seq_TH1_Human1.48776453
56EZH2_27294783_Chip-Seq_ESCs_Mouse1.48602357
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47831110
58SMC4_20622854_ChIP-Seq_HELA_Human1.46069242
59* AR_21909140_ChIP-Seq_LNCAP_Human1.45182366
60* AR_19668381_ChIP-Seq_PC3_Human1.45001266
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.44940031
62* LXR_22292898_ChIP-Seq_THP-1_Human1.44306977
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44235915
64AHR_22903824_ChIP-Seq_MCF-7_Human1.43282037
65SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.41682671
66MYB_26560356_Chip-Seq_TH1_Human1.41396644
67GATA1_19941826_ChIP-Seq_K562_Human1.41390584
68* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40664275
69ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.40402121
70* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38373419
71NANOG_18555785_ChIP-Seq_MESCs_Mouse1.37709170
72RNF2_27304074_Chip-Seq_ESCs_Mouse1.35963313
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35937341
74KDM5A_27292631_Chip-Seq_BREAST_Human1.35900177
75BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.35791549
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.34583363
77XRN2_22483619_ChIP-Seq_HELA_Human1.33168924
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31810442
79NELFA_20434984_ChIP-Seq_ESCs_Mouse1.30544779
80FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.30434321
81SMAD3_21741376_ChIP-Seq_ESCs_Human1.28826530
82ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28502280
83SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28448923
84STAT1_20625510_ChIP-Seq_HELA_Human1.27457405
85RXR_22108803_ChIP-Seq_LS180_Human1.27267908
86YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26728697
87ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25819512
88* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.25140977
89NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.23523481
90SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23351920
91PKCTHETA_26484144_Chip-Seq_BREAST_Human1.22845755
92VDR_24763502_ChIP-Seq_THP-1_Human1.22548776
93SPI1_23127762_ChIP-Seq_K562_Human1.22148933
94NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22095488
95ELK3_25401928_ChIP-Seq_HUVEC_Human1.21908244
96MYC_18358816_ChIP-ChIP_MESCs_Mouse1.21035949
97EZH2_18974828_ChIP-Seq_MESCs_Mouse1.20540902
98RNF2_18974828_ChIP-Seq_MESCs_Mouse1.20540902
99KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19494563
100MYB_26560356_Chip-Seq_TH2_Human1.19177927
101TCF4_23295773_ChIP-Seq_U87_Human1.19071045
102TTF2_22483619_ChIP-Seq_HELA_Human1.19024379
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18303861
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18303861
105MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17901807
106STAT3_23295773_ChIP-Seq_U87_Human1.17688216
107AR_21572438_ChIP-Seq_LNCaP_Human1.15791109
108EZH2_27304074_Chip-Seq_ESCs_Mouse1.15765364
109ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15690234
110* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.14812335
111MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.14498574
112RARB_24833708_ChIP-Seq_LIVER_Mouse1.14272744
113TDRD3_21172665_ChIP-Seq_MCF-7_Human1.12034515
114EST1_17652178_ChIP-ChIP_JURKAT_Human1.11895429
115NCOR1_26117541_ChIP-Seq_K562_Human1.11868152
116STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.11733262
117OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.11532497
118E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11528851
119TCF3_18692474_ChIP-Seq_MEFs_Mouse1.11460127
120RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10797486
121KDM2B_26808549_Chip-Seq_K562_Human1.10577657
122RUNX1_27514584_Chip-Seq_MCF-7_Human1.09484724
123RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08865921
124CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08436461
125WDR5_24793694_ChIP-Seq_LNCAP_Human1.08413638
126FOXP3_21729870_ChIP-Seq_TREG_Human1.08040625
127* KLF4_19829295_ChIP-Seq_ESCs_Human1.07809515
128DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07572051
129HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07294429
130GATA1_19941827_ChIP-Seq_MEL86_Mouse1.06874298
131OCT4_19829295_ChIP-Seq_ESCs_Human1.06594567
132CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06462204
133ELK4_26923725_Chip-Seq_MESODERM_Mouse1.06304270
134SPI1_23547873_ChIP-Seq_NB4_Human1.06026007
135MAF_26560356_Chip-Seq_TH2_Human1.06021119
136TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05450574
137CTCF_27219007_Chip-Seq_Bcells_Human1.05384476
138GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04976104
139EED_16625203_ChIP-ChIP_MESCs_Mouse1.04911861
140MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03142610
141TCF3_18692474_ChIP-Seq_MESCs_Mouse1.03099379
142ER_23166858_ChIP-Seq_MCF-7_Human1.02592029
143VDR_23849224_ChIP-Seq_CD4+_Human1.01739212
144RUNX1_22412390_ChIP-Seq_EML_Mouse1.01247708
145NANOG_21062744_ChIP-ChIP_HESCs_Human1.00961654
146SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00871619
147* KDM2B_26808549_Chip-Seq_JURKAT_Human1.00693272
148MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00062317
149RUNX_20019798_ChIP-Seq_JUKART_Human0.99604362
150KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99056829
151SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99015114
152CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98772486
153SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98391312
154FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.98347183
155SA1_27219007_Chip-Seq_ERYTHROID_Human0.97466663
156SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96763967
157TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95932422
158* BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.95860802
159* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95779046
160PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95376643
161MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95161178
162REST_18959480_ChIP-ChIP_MESCs_Mouse0.95104860
163* TP63_22573176_ChIP-Seq_HFKS_Human0.94830658
164E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92729574
165ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92673186
166SMAD3_21741376_ChIP-Seq_HESCs_Human0.92325149
167EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91871634
168DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91864815
169NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.90629349
170* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.89588608
171POU5F1_16518401_ChIP-PET_MESCs_Mouse0.89465646
172SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89417958
173VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.89150809
174TP63_17297297_ChIP-ChIP_HaCaT_Human0.88493349
175HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87962405
176NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.87288582
177ELF1_17652178_ChIP-ChIP_JURKAT_Human0.86776382
178CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.86441113
179PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86401723
180STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86055473
181TFEB_21752829_ChIP-Seq_HELA_Human0.84712681
182KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82287309
183KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.81553154
184KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81495997
185POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.81156980

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose4.59690563
2MP0002138_abnormal_hepatobiliary_system4.36501975
3MP0008260_abnormal_autophagy4.14619502
4MP0006082_CNS_inflammation4.05378204
5MP0005377_hearing/vestibular/ear_phenot3.89687299
6MP0003878_abnormal_ear_physiology3.89687299
7MP0008057_abnormal_DNA_replication3.60325278
8MP0001188_hyperpigmentation3.26920337
9MP0003111_abnormal_nucleus_morphology3.06856383
10MP0010094_abnormal_chromosome_stability3.03687985
11MP0003693_abnormal_embryo_hatching2.96876512
12MP0004185_abnormal_adipocyte_glucose2.85636356
13MP0003077_abnormal_cell_cycle2.67044864
14MP0002396_abnormal_hematopoietic_system2.59795458
15MP0003879_abnormal_hair_cell2.40209841
16MP0001348_abnormal_lacrimal_gland2.37042859
17* MP0004957_abnormal_blastocyst_morpholog2.27250487
18MP0009278_abnormal_bone_marrow2.22834289
19MP0010352_gastrointestinal_tract_polyps2.18300788
20MP0004043_abnormal_pH_regulation2.15084820
21MP0008058_abnormal_DNA_repair2.14582788
22MP0005076_abnormal_cell_differentiation2.14076777
23MP0001485_abnormal_pinna_reflex2.13840543
24MP0008877_abnormal_DNA_methylation2.13345290
25MP0003646_muscle_fatigue2.12079722
26MP0003045_fibrosis2.10216962
27MP0001501_abnormal_sleep_pattern2.08669477
28MP0003183_abnormal_peptide_metabolism2.05247136
29MP0004808_abnormal_hematopoietic_stem2.03578571
30MP0000750_abnormal_muscle_regeneration1.97182551
31MP0008007_abnormal_cellular_replicative1.88897583
32MP0004233_abnormal_muscle_weight1.87996521
33MP0005397_hematopoietic_system_phenotyp1.81994628
34MP0001545_abnormal_hematopoietic_system1.81994628
35MP0005666_abnormal_adipose_tissue1.80950747
36MP0000350_abnormal_cell_proliferation1.79256524
37MP0004883_abnormal_blood_vessel1.78711965
38MP0003121_genomic_imprinting1.72402181
39MP0002736_abnormal_nociception_after1.67976676
40MP0003763_abnormal_thymus_physiology1.64813399
41MP0001730_embryonic_growth_arrest1.64426299
42* MP0005380_embryogenesis_phenotype1.63347205
43* MP0001672_abnormal_embryogenesis/_devel1.63347205
44MP0004197_abnormal_fetal_growth/weight/1.61087916
45MP0006054_spinal_hemorrhage1.56713097
46MP0003690_abnormal_glial_cell1.56617175
47MP0003123_paternal_imprinting1.55479941
48* MP0003984_embryonic_growth_retardation1.54850961
49MP0003315_abnormal_perineum_morphology1.54211522
50* MP0002088_abnormal_embryonic_growth/wei1.51694260
51MP0001968_abnormal_touch/_nociception1.51045601
52MP0010307_abnormal_tumor_latency1.48753399
53MP0003195_calcinosis1.48573922
54MP0000703_abnormal_thymus_morphology1.47106237
55MP0000490_abnormal_crypts_of1.47070041
56* MP0002085_abnormal_embryonic_tissue1.46807873
57MP0002084_abnormal_developmental_patter1.46450764
58MP0005551_abnormal_eye_electrophysiolog1.46030524
59MP0008932_abnormal_embryonic_tissue1.45934051
60MP0003567_abnormal_fetal_cardiomyocyte1.43751182
61MP0002398_abnormal_bone_marrow1.40602352
62MP0001697_abnormal_embryo_size1.40123148
63MP0010030_abnormal_orbit_morphology1.39685982
64MP0002086_abnormal_extraembryonic_tissu1.39178928
65MP0003786_premature_aging1.38936772
66MP0006292_abnormal_olfactory_placode1.38046780
67MP0004130_abnormal_muscle_cell1.30048338
68MP0003787_abnormal_imprinting1.28222541
69MP0008995_early_reproductive_senescence1.28073054
70MP0009046_muscle_twitch1.26883922
71MP0009053_abnormal_anal_canal1.26807347
72MP0009333_abnormal_splenocyte_physiolog1.25295814
73MP0004142_abnormal_muscle_tone1.21643452
74MP0009745_abnormal_behavioral_response1.20202390
75MP0001293_anophthalmia1.18957808
76MP0008961_abnormal_basal_metabolism1.18805811
77MP0004019_abnormal_vitamin_homeostasis1.18176039
78MP0002229_neurodegeneration1.16975075
79MP0005174_abnormal_tail_pigmentation1.15823330
80MP0004381_abnormal_hair_follicle1.15364743
81MP0002722_abnormal_immune_system1.14856912
82MP0003136_yellow_coat_color1.14492359
83MP0000313_abnormal_cell_death1.14376288
84MP0004858_abnormal_nervous_system1.13624892
85MP0003950_abnormal_plasma_membrane1.13196055
86MP0000432_abnormal_head_morphology1.11398432
87MP0000026_abnormal_inner_ear1.11275509
88* MP0002080_prenatal_lethality1.11045452
89MP0003436_decreased_susceptibility_to1.10458336
90MP0002735_abnormal_chemical_nociception1.09789101
91MP0002019_abnormal_tumor_incidence1.09718106
92MP0000516_abnormal_urinary_system1.09692204
93MP0005367_renal/urinary_system_phenotyp1.09692204
94MP0003385_abnormal_body_wall1.08289241
95MP0003941_abnormal_skin_development1.07623226
96MP0003890_abnormal_embryonic-extraembry1.07234250
97MP0003828_pulmonary_edema1.07186333
98MP0002928_abnormal_bile_duct1.06802291
99MP0000689_abnormal_spleen_morphology1.06746100
100MP0000631_abnormal_neuroendocrine_gland1.05497375
101MP0003935_abnormal_craniofacial_develop1.05394333
102MP0001800_abnormal_humoral_immune1.05022830
103MP0005375_adipose_tissue_phenotype1.04291526
104MP0003119_abnormal_digestive_system1.04276195
105MP0002249_abnormal_larynx_morphology1.03304473
106MP0002925_abnormal_cardiovascular_devel1.03060844
107MP0004742_abnormal_vestibular_system1.02454048
108MP0003937_abnormal_limbs/digits/tail_de1.01018671
109MP0000049_abnormal_middle_ear0.99267891
110MP0003635_abnormal_synaptic_transmissio0.98529654
111MP0000716_abnormal_immune_system0.98341049
112MP0003303_peritoneal_inflammation0.97509777
113MP0000733_abnormal_muscle_development0.97371922
114MP0003300_gastrointestinal_ulcer0.97311214
115MP0001915_intracranial_hemorrhage0.97051090
116MP0003755_abnormal_palate_morphology0.95750984
117MP0009703_decreased_birth_body0.95598002
118MP0005310_abnormal_salivary_gland0.95178650
119MP0009672_abnormal_birth_weight0.95167749
120MP0002405_respiratory_system_inflammati0.95124732
121MP0001486_abnormal_startle_reflex0.94045455
122MP0002429_abnormal_blood_cell0.92533843
123MP0002210_abnormal_sex_determination0.91440940
124MP0002064_seizures0.91429770
125MP0001970_abnormal_pain_threshold0.91263091
126MP0005409_darkened_coat_color0.91162244
127MP0001849_ear_inflammation0.90013055
128MP0000428_abnormal_craniofacial_morphol0.89840274
129MP0002166_altered_tumor_susceptibility0.88824628
130MP0000566_synostosis0.87893368
131MP0005423_abnormal_somatic_nervous0.85584833
132MP0002452_abnormal_antigen_presenting0.85455218
133MP0002420_abnormal_adaptive_immunity0.85424866
134MP0000470_abnormal_stomach_morphology0.83921092
135MP0001819_abnormal_immune_cell0.83833599
136MP0001286_abnormal_eye_development0.82568142
137MP0002006_tumorigenesis0.81900412
138MP0001790_abnormal_immune_system0.81681508
139MP0005387_immune_system_phenotype0.81681508
140MP0003122_maternal_imprinting0.81596052
141MP0002272_abnormal_nervous_system0.81535517
142MP0003115_abnormal_respiratory_system0.81502853
143MP0004859_abnormal_synaptic_plasticity0.81477066
144MP0002009_preneoplasia0.81151377
145MP0005023_abnormal_wound_healing0.80347720
146MP0000685_abnormal_immune_system0.79875590
147* MP0002116_abnormal_craniofacial_bone0.79459266
148MP0002168_other_aberrant_phenotype0.78631661
149MP0008872_abnormal_physiological_respon0.78222917
150MP0000015_abnormal_ear_pigmentation0.77939400
151MP0005671_abnormal_response_to0.77677129
152MP0001119_abnormal_female_reproductive0.77557201
153MP0003566_abnormal_cell_adhesion0.76845060
154MP0005075_abnormal_melanosome_morpholog0.76840198
155MP0005448_abnormal_energy_balance0.76823179
156MP0002638_abnormal_pupillary_reflex0.76511109
157MP0000678_abnormal_parathyroid_gland0.74799587
158MP0005623_abnormal_meninges_morphology0.74583476
159MP0000767_abnormal_smooth_muscle0.74369810
160MP0003252_abnormal_bile_duct0.74068170
161MP0008569_lethality_at_weaning0.73836294
162MP0002733_abnormal_thermal_nociception0.73343117
163MP0002653_abnormal_ependyma_morphology0.73111389
164MP0001963_abnormal_hearing_physiology0.73076250
165MP0000538_abnormal_urinary_bladder0.72481481
166MP0005595_abnormal_vascular_smooth0.71860261
167MP0002067_abnormal_sensory_capabilities0.71006976
168MP0002572_abnormal_emotion/affect_behav0.70887527
169MP0000955_abnormal_spinal_cord0.70261863
170MP0009115_abnormal_fat_cell0.69627092
171MP0002184_abnormal_innervation0.67555857
172MP0005266_abnormal_metabolism0.67504386
173MP0002557_abnormal_social/conspecific_i0.66905944
174MP0000230_abnormal_systemic_arterial0.61350907
175MP0002882_abnormal_neuron_morphology0.60361212
176MP0002063_abnormal_learning/memory/cond0.59968634
177MP0006276_abnormal_autonomic_nervous0.59393041
178MP0002998_abnormal_bone_remodeling0.58782585
179MP0005646_abnormal_pituitary_gland0.58561516
180MP0005083_abnormal_biliary_tract0.58536706
181MP0005376_homeostasis/metabolism_phenot0.58103601
182MP0005166_decreased_susceptibility_to0.55756709
183MP0000920_abnormal_myelination0.55369287
184MP0005195_abnormal_posterior_eye0.54388138

Predicted human phenotypes

RankGene SetZ-score
1Deep palmar crease (HP:0006191)6.17203084
2Severe visual impairment (HP:0001141)5.53709898
3Scotoma (HP:0000575)5.22670491
4Central scotoma (HP:0000603)4.96878099
5Genetic anticipation (HP:0003743)4.94622087
6Ileus (HP:0002595)4.53448511
7Abnormality of the fingertips (HP:0001211)4.24389816
8Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.17891966
9Cortical dysplasia (HP:0002539)4.14482644
10Bony spicule pigmentary retinopathy (HP:0007737)4.11957535
11Dysmetric saccades (HP:0000641)3.88930485
12Congenital stationary night blindness (HP:0007642)3.85083338
13Progressive cerebellar ataxia (HP:0002073)3.72378444
14Submucous cleft hard palate (HP:0000176)3.58265875
15Increased neuronal autofluorescent lipopigment (HP:0002074)3.35006386
16Attenuation of retinal blood vessels (HP:0007843)3.34941272
17Chromsome breakage (HP:0040012)3.33067579
18Abnormality of binocular vision (HP:0011514)3.32343045
19Diplopia (HP:0000651)3.32343045
20Clumsiness (HP:0002312)3.17437974
21Ectopic kidney (HP:0000086)3.15623241
22Long eyelashes (HP:0000527)3.12499162
23Bulbous nose (HP:0000414)3.11240907
24Chromosomal breakage induced by crosslinking agents (HP:0003221)3.05562553
25Epidermoid cyst (HP:0200040)3.01457817
26Hyperlipoproteinemia (HP:0010980)2.82338522
27Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.81206485
28Short 4th metacarpal (HP:0010044)2.81206485
29Volvulus (HP:0002580)2.70734090
30Facial hemangioma (HP:0000329)2.65257752
31Curly hair (HP:0002212)2.64400639
32Increased cerebral lipofuscin (HP:0011813)2.59110660
33Rib fusion (HP:0000902)2.58596391
34Intestinal fistula (HP:0100819)2.56332414
35Congenital sensorineural hearing impairment (HP:0008527)2.55117591
36Gaze-evoked nystagmus (HP:0000640)2.54050989
37Abnormal number of incisors (HP:0011064)2.53840172
38Supernumerary ribs (HP:0005815)2.51999335
39Patellar aplasia (HP:0006443)2.51540055
40Urethral obstruction (HP:0000796)2.51277083
41Abnormality of the aortic arch (HP:0012303)2.45293714
42Trigonocephaly (HP:0000243)2.44382493
43Deviation of the thumb (HP:0009603)2.43895506
44Anal stenosis (HP:0002025)2.41940001
45Proximal placement of thumb (HP:0009623)2.40746657
46Hypopigmentation of the fundus (HP:0007894)2.36988160
47Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.36036643
48Aplasia/Hypoplasia of the patella (HP:0006498)2.35694969
49Syringomyelia (HP:0003396)2.31046674
50Spinal cord lesions (HP:0100561)2.31046674
51Supernumerary bones of the axial skeleton (HP:0009144)2.30230603
52Decreased electroretinogram (ERG) amplitude (HP:0000654)2.29462721
53Medulloblastoma (HP:0002885)2.28678465
54Absent eyebrow (HP:0002223)2.28330767
55Abnormality of the nasal septum (HP:0000419)2.27173057
56Abnormality of the antihelix (HP:0009738)2.26594406
57Increased nuchal translucency (HP:0010880)2.25942840
58Absent eyelashes (HP:0000561)2.25471374
59Lip pit (HP:0100267)2.23191533
60Meckel diverticulum (HP:0002245)2.21953059
61Hypoplastic ischia (HP:0003175)2.21778803
62Sparse lateral eyebrow (HP:0005338)2.20549158
63Skin nodule (HP:0200036)2.20415244
64Abnormality of the ileum (HP:0001549)2.13255471
65Prominent nose (HP:0000448)2.13245062
66Short chin (HP:0000331)2.11101179
67Progressive visual loss (HP:0000529)2.10835110
68Impulsivity (HP:0100710)2.10584788
69Glossoptosis (HP:0000162)2.09800533
70Thickened helices (HP:0000391)2.09508823
71Long palpebral fissure (HP:0000637)2.09487440
72Broad palm (HP:0001169)2.08304207
73Broad thumb (HP:0011304)2.07300219
74Selective tooth agenesis (HP:0001592)2.07278580
75Depressed nasal tip (HP:0000437)2.06769048
76Abnormality of the columella (HP:0009929)2.04835119
77Abnormality of chromosome stability (HP:0003220)2.03586182
78Shawl scrotum (HP:0000049)2.01165943
79Acute lymphatic leukemia (HP:0006721)2.00914113
80Abnormality of the intervertebral disk (HP:0005108)2.00031566
81Myelodysplasia (HP:0002863)1.98163516
82Abnormality of the parietal bone (HP:0002696)1.97897900
83Abnormal rod and cone electroretinograms (HP:0008323)1.97177767
84Aplasia/Hypoplasia of the uvula (HP:0010293)1.96606134
85Hypoplasia of the iris (HP:0007676)1.95441406
86Pachygyria (HP:0001302)1.94766601
87Slow-growing hair (HP:0002217)1.94685314
88Abnormality of hair growth rate (HP:0011363)1.94685314
89Cystic hygroma (HP:0000476)1.94618099
90Short thumb (HP:0009778)1.94142499
91Aplasia/Hypoplasia of the sternum (HP:0006714)1.94033867
92Acute myeloid leukemia (HP:0004808)1.93965108
93Abnormality of the preputium (HP:0100587)1.93923073
94Increased corneal curvature (HP:0100692)1.91746821
95Keratoconus (HP:0000563)1.91746821
96Short 5th finger (HP:0009237)1.91314410
97Autoimmune hemolytic anemia (HP:0001890)1.90907836
98Absent radius (HP:0003974)1.90797065
99Constricted visual fields (HP:0001133)1.90673297
100Pendular nystagmus (HP:0012043)1.90475076
101Stereotypic behavior (HP:0000733)1.90062787
102Abnormality of the distal phalanx of the thumb (HP:0009617)1.89004556
103Absent thumb (HP:0009777)1.88379091
104Sparse scalp hair (HP:0002209)1.88322527
105Areflexia of lower limbs (HP:0002522)1.88218942
106Abnormality of the incisor (HP:0000676)1.85951242
107Abnormality of the 4th metacarpal (HP:0010012)1.85760032
108Skin tags (HP:0010609)1.85254476
109Flared iliac wings (HP:0002869)1.85176100
110Neoplasm of the oral cavity (HP:0100649)1.85114825
111Abnormality of macular pigmentation (HP:0008002)1.83879219
112Ependymoma (HP:0002888)1.83743766
113Easy fatigability (HP:0003388)1.82885175
114Poor head control (HP:0002421)1.81860768
115Xanthomatosis (HP:0000991)1.81637652
116Birth length less than 3rd percentile (HP:0003561)1.80224298
117Clubbing of toes (HP:0100760)1.79250363
118Thick eyebrow (HP:0000574)1.79067075
119Enlarged kidneys (HP:0000105)1.78312488
120Aplasia involving forearm bones (HP:0009822)1.78135372
121Absent forearm bone (HP:0003953)1.78135372
122Abnormality of the phalanges of the hallux (HP:0010057)1.78098141
123Deep philtrum (HP:0002002)1.76971627
124Facial diplegia (HP:0001349)1.76865328
125Dislocated radial head (HP:0003083)1.76522512
126Abnormality of the ischium (HP:0003174)1.76368937
127Enlarged penis (HP:0000040)1.73607873
128Abnormality of the labia minora (HP:0012880)1.72806422
129Abnormality of small intestinal villus morphology (HP:0011472)1.72728127
130Villous atrophy (HP:0011473)1.72728127
131Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.72709437
132Narrow palate (HP:0000189)1.71578470
133Obstructive sleep apnea (HP:0002870)1.71238158
134Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.70496655
135Flat capital femoral epiphysis (HP:0003370)1.70336901
136Rectal fistula (HP:0100590)1.69181309
137Rectovaginal fistula (HP:0000143)1.69181309
138Autoimmune thrombocytopenia (HP:0001973)1.68784288
139Impaired smooth pursuit (HP:0007772)1.68491826
140Short phalanx of the thumb (HP:0009660)1.67833007
141Preauricular skin tag (HP:0000384)1.67799680
142Atresia of the external auditory canal (HP:0000413)1.67735935
143Spina bifida occulta (HP:0003298)1.67685516
144Relative macrocephaly (HP:0004482)1.67430669
145Abnormality of the radial head (HP:0003995)1.66768759
146Underdeveloped supraorbital ridges (HP:0009891)1.65953244
147Underdeveloped nasal alae (HP:0000430)1.64779458
148Skull defect (HP:0001362)1.64629143
149Basal cell carcinoma (HP:0002671)1.64353342
150Preaxial foot polydactyly (HP:0001841)1.64246947
151Carpal bone hypoplasia (HP:0001498)1.63849030
152Short 1st metacarpal (HP:0010034)1.63599128
153Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.63599128
154Overlapping toe (HP:0001845)1.63579673
155Chin dimple (HP:0010751)1.63207068
156Macroorchidism (HP:0000053)1.63120637
157Colon cancer (HP:0003003)1.62475860
158Limited elbow extension (HP:0001377)1.62167680
159Broad phalanges of the hand (HP:0009768)1.61562888
160Broad hallux (HP:0010055)1.61160010
161Pustule (HP:0200039)1.61038221
162Small intestinal stenosis (HP:0012848)1.60800173
163Duodenal stenosis (HP:0100867)1.60800173
164Cutis marmorata (HP:0000965)1.60690585
165High anterior hairline (HP:0009890)1.60456143
166Abnormality of the carotid arteries (HP:0005344)1.59945045
167Type I transferrin isoform profile (HP:0003642)1.59722245
168Onion bulb formation (HP:0003383)1.59565467
169Renal duplication (HP:0000075)1.58940311
170Reticulocytopenia (HP:0001896)1.58282738
171Low anterior hairline (HP:0000294)1.58120295
172Rhabdomyosarcoma (HP:0002859)1.58061599
173Broad toe (HP:0001837)1.57501779
174Neoplasm of striated muscle (HP:0009728)1.57334021
175Short middle phalanx of the 5th finger (HP:0004220)1.56889824
176Breast hypoplasia (HP:0003187)1.56752231
177Increased number of teeth (HP:0011069)1.56582640
178Synophrys (HP:0000664)1.56371773
179Heterotopia (HP:0002282)1.56349579
180Abnormality of incisor morphology (HP:0011063)1.55644127
181Optic nerve coloboma (HP:0000588)1.54432183

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.68249174
2TAF15.14557154
3FRK4.84759028
4PIK3CG4.09650130
5CDC73.22316187
6BRD43.07770766
7MKNK22.61945832
8MAP3K102.56927491
9EEF2K2.42813669
10NEK22.18408427
11BRAF2.18319892
12MAP4K12.17005498
13MKNK12.13664848
14ERN12.12819261
15CDK72.04473463
16LATS12.01994279
17PTK21.96007064
18ILK1.94622235
19SGK21.91302204
20KSR11.78888714
21STK101.73965241
22EPHB11.72279804
23DMPK1.68928361
24CDK41.68785581
25SRPK11.57997630
26PIM11.57476958
27TNK21.51848297
28SIK21.40750365
29CAMK1D1.39218240
30SGK2231.39007508
31SGK4941.39007508
32RIPK11.37953548
33CLK11.35383015
34TTK1.33567277
35SIK31.33191628
36CAMK1G1.32801839
37ATR1.30530972
38STK31.30269495
39MTOR1.29809349
40CDK61.29396059
41CHUK1.28894484
42STK41.27029253
43CHEK21.23486338
44CHEK11.21472510
45WEE11.18226322
46TRIB31.16077457
47PLK11.15766397
48NUAK11.13577927
49TAOK11.13565304
50TXK1.11338529
51PLK41.08951926
52NTRK31.08917375
53ATM1.08404363
54RPS6KA41.05529239
55SIK11.03861373
56CDK91.03092339
57NLK1.01740093
58RPS6KB21.01222850
59ICK0.99668413
60* CDK20.98490719
61MAP2K30.96405985
62PRKD20.95209057
63ALK0.94927520
64LATS20.94488659
65AURKB0.89223894
66SMG10.86318796
67STK240.85433985
68JAK30.79771523
69MARK30.77212136
70YES10.75701071
71CDK80.74229375
72MAP3K110.72589943
73PLK30.72361480
74CDK10.72256527
75PRKCH0.70870585
76IKBKB0.70262937
77GRK60.69458787
78BTK0.68455455
79TSSK60.68382554
80PTK2B0.67208169
81MAP3K70.64624054
82STK110.63986140
83AKT30.63926882
84PNCK0.63864111
85IKBKE0.63803635
86MELK0.62930824
87* MAPK140.62775850
88TRPM70.62754450
89MAP3K90.60192418
90FGFR30.59650115
91MAP3K80.59634203
92BMX0.57482508
93INSRR0.57269850
94ZAP700.56969269
95CSK0.56235187
96PIM20.56225142
97MAPK10.55286929
98FGFR40.54811450
99BUB10.53852576
100AKT10.52992659
101GSK3B0.52797492
102BRSK20.50350908
103CDK30.49671321
104RPS6KA60.48960524
105IRAK40.48460601
106RPS6KL10.48002145
107RPS6KC10.48002145
108PRKD30.47850170
109MARK20.47359117
110ACVR1B0.46260023
111CAMK40.45786462
112PRKCZ0.45623344
113RPS6KA10.44145359
114HCK0.43902482
115MAP3K60.43640854
116MAPKAPK20.42428295
117STK38L0.41500140
118CSNK1E0.41203058
119LCK0.40885714
120HIPK20.39967134
121CDK190.39938191
122PRKDC0.39642060
123ADRBK20.38626235
124MAPK80.37630554
125MAPK100.36590541
126DDR20.36406144
127PRKCI0.36183218
128MAPKAPK30.36052716
129PRPF4B0.36052638
130SGK30.35609045
131EPHA20.35291671
132MAPK30.35098443
133CDC42BPA0.34922206
134PDGFRB0.34775948
135SGK10.33233360
136CAMK10.32637389
137MUSK0.31514717
138TYRO30.31086768
139IRAK10.29875855
140MAP2K10.29402884
141WNK10.29255296
142MAP2K60.28824903
143DAPK10.28486717
144SYK0.28201099
145PDK10.27202728
146LRRK20.26953115
147FER0.25075748
148RPS6KA20.24478657
149BMPR1B0.24414953
150PDPK10.23371572
151ITK0.22713204
152STK380.22692485
153GSK3A0.22234894
154PRKCG0.22011118
155FGFR20.21732272
156ADRBK10.21548851
157OXSR10.21218287
158EPHA30.20944515

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.69063473
2Mismatch repair_Homo sapiens_hsa034302.58126857
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.36828921
4Spliceosome_Homo sapiens_hsa030402.36335505
5Cell cycle_Homo sapiens_hsa041102.31853931
6Base excision repair_Homo sapiens_hsa034102.20680049
7Homologous recombination_Homo sapiens_hsa034402.18352606
8RNA transport_Homo sapiens_hsa030132.16856805
9Fanconi anemia pathway_Homo sapiens_hsa034602.04726489
10Sulfur relay system_Homo sapiens_hsa041221.95024641
11ABC transporters_Homo sapiens_hsa020101.93840184
12mRNA surveillance pathway_Homo sapiens_hsa030151.91418320
13Glioma_Homo sapiens_hsa052141.78862916
14Phototransduction_Homo sapiens_hsa047441.77323105
15Nicotine addiction_Homo sapiens_hsa050331.77242105
16Primary immunodeficiency_Homo sapiens_hsa053401.69269797
17Non-homologous end-joining_Homo sapiens_hsa034501.67101254
18Notch signaling pathway_Homo sapiens_hsa043301.61825074
19Long-term potentiation_Homo sapiens_hsa047201.61152602
20RNA degradation_Homo sapiens_hsa030181.54676921
21Nucleotide excision repair_Homo sapiens_hsa034201.54198101
22RNA polymerase_Homo sapiens_hsa030201.54181616
23Basal transcription factors_Homo sapiens_hsa030221.50219151
24p53 signaling pathway_Homo sapiens_hsa041151.49011168
25MicroRNAs in cancer_Homo sapiens_hsa052061.47955669
26Herpes simplex infection_Homo sapiens_hsa051681.47708305
27Phospholipase D signaling pathway_Homo sapiens_hsa040721.40620672
28Adherens junction_Homo sapiens_hsa045201.38937677
29Transcriptional misregulation in cancer_Homo sapiens_hsa052021.36980063
30Basal cell carcinoma_Homo sapiens_hsa052171.34621914
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.32197620
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31623810
33Estrogen signaling pathway_Homo sapiens_hsa049151.31386943
34VEGF signaling pathway_Homo sapiens_hsa043701.31366299
35Long-term depression_Homo sapiens_hsa047301.29090789
36Cholinergic synapse_Homo sapiens_hsa047251.27356152
37Circadian entrainment_Homo sapiens_hsa047131.26864327
38Fatty acid elongation_Homo sapiens_hsa000621.26202089
39One carbon pool by folate_Homo sapiens_hsa006701.24251894
40Chronic myeloid leukemia_Homo sapiens_hsa052201.23077430
41Acute myeloid leukemia_Homo sapiens_hsa052211.23034140
42HTLV-I infection_Homo sapiens_hsa051661.22912633
43Lysine degradation_Homo sapiens_hsa003101.21711836
44Vascular smooth muscle contraction_Homo sapiens_hsa042701.20314014
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.20028796
46Ribosome_Homo sapiens_hsa030101.18755115
47Epstein-Barr virus infection_Homo sapiens_hsa051691.14840403
48Glutamatergic synapse_Homo sapiens_hsa047241.14510728
49Thyroid cancer_Homo sapiens_hsa052161.14381467
50B cell receptor signaling pathway_Homo sapiens_hsa046621.13757356
51Measles_Homo sapiens_hsa051621.13319054
52Type II diabetes mellitus_Homo sapiens_hsa049301.11921645
53Morphine addiction_Homo sapiens_hsa050321.11831899
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11389720
55Colorectal cancer_Homo sapiens_hsa052101.11307021
56Aldosterone synthesis and secretion_Homo sapiens_hsa049251.11186263
57Serotonergic synapse_Homo sapiens_hsa047261.10338607
58Small cell lung cancer_Homo sapiens_hsa052221.09610404
59Calcium signaling pathway_Homo sapiens_hsa040201.08523987
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08473051
61Prostate cancer_Homo sapiens_hsa052151.07400010
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06796499
63Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05337839
64Hepatitis B_Homo sapiens_hsa051611.05035801
65Ovarian steroidogenesis_Homo sapiens_hsa049131.04826743
66Antigen processing and presentation_Homo sapiens_hsa046121.04257025
67TGF-beta signaling pathway_Homo sapiens_hsa043500.99930620
68Viral carcinogenesis_Homo sapiens_hsa052030.99773992
69T cell receptor signaling pathway_Homo sapiens_hsa046600.99667190
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99236004
71Gastric acid secretion_Homo sapiens_hsa049710.98641313
72Wnt signaling pathway_Homo sapiens_hsa043100.98319665
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98261784
74Hippo signaling pathway_Homo sapiens_hsa043900.98167119
75Viral myocarditis_Homo sapiens_hsa054160.97078503
76Hematopoietic cell lineage_Homo sapiens_hsa046400.95797205
77cAMP signaling pathway_Homo sapiens_hsa040240.93645751
78Pancreatic cancer_Homo sapiens_hsa052120.93236199
79Salivary secretion_Homo sapiens_hsa049700.92705625
80Pathways in cancer_Homo sapiens_hsa052000.92334596
81Butanoate metabolism_Homo sapiens_hsa006500.92208201
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.91409708
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90686689
84Regulation of autophagy_Homo sapiens_hsa041400.90405877
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.88860716
86Oxytocin signaling pathway_Homo sapiens_hsa049210.87843594
87Leishmaniasis_Homo sapiens_hsa051400.87804433
88Insulin secretion_Homo sapiens_hsa049110.87691998
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87580433
90Melanogenesis_Homo sapiens_hsa049160.86976521
91Cocaine addiction_Homo sapiens_hsa050300.86968810
92Hedgehog signaling pathway_Homo sapiens_hsa043400.86053342
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85890220
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85488934
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84155559
96Pyrimidine metabolism_Homo sapiens_hsa002400.84046233
97Graft-versus-host disease_Homo sapiens_hsa053320.83935250
98Endometrial cancer_Homo sapiens_hsa052130.83907472
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82781437
100GnRH signaling pathway_Homo sapiens_hsa049120.82320689
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82279149
102Influenza A_Homo sapiens_hsa051640.80974078
103Non-small cell lung cancer_Homo sapiens_hsa052230.80361739
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79972809
105Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79784046
106Osteoclast differentiation_Homo sapiens_hsa043800.79129633
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78477946
108Apoptosis_Homo sapiens_hsa042100.78015212
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76572846
110Shigellosis_Homo sapiens_hsa051310.76137137
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76057233
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75563573
113Proteoglycans in cancer_Homo sapiens_hsa052050.75063817
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.74942739
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.74698310
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74430004
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74090944
118Ras signaling pathway_Homo sapiens_hsa040140.72682089
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72624589
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72280380
121GABAergic synapse_Homo sapiens_hsa047270.71831119
122Choline metabolism in cancer_Homo sapiens_hsa052310.71633470
123Dorso-ventral axis formation_Homo sapiens_hsa043200.71419890
124FoxO signaling pathway_Homo sapiens_hsa040680.70755449
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.69806811
126Hepatitis C_Homo sapiens_hsa051600.68691882
127Toxoplasmosis_Homo sapiens_hsa051450.66810020
128Glycerolipid metabolism_Homo sapiens_hsa005610.66702493
129Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65068021
130Dopaminergic synapse_Homo sapiens_hsa047280.63962527
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63172912
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60518003
133Oocyte meiosis_Homo sapiens_hsa041140.60164188
134RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59803033
135Insulin signaling pathway_Homo sapiens_hsa049100.59314404
136Taste transduction_Homo sapiens_hsa047420.59238340
137Renal cell carcinoma_Homo sapiens_hsa052110.58832946
138mTOR signaling pathway_Homo sapiens_hsa041500.58757805
139Prolactin signaling pathway_Homo sapiens_hsa049170.57953168
140Olfactory transduction_Homo sapiens_hsa047400.57916948
141Platelet activation_Homo sapiens_hsa046110.57496613
142TNF signaling pathway_Homo sapiens_hsa046680.57489114
143cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57343259
144Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56927841
145Focal adhesion_Homo sapiens_hsa045100.56617555
146AMPK signaling pathway_Homo sapiens_hsa041520.55999366
147Melanoma_Homo sapiens_hsa052180.55916455
148PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55598618
149Chemokine signaling pathway_Homo sapiens_hsa040620.55076999
150Bladder cancer_Homo sapiens_hsa052190.54645294
151HIF-1 signaling pathway_Homo sapiens_hsa040660.53383067
152Inositol phosphate metabolism_Homo sapiens_hsa005620.52039599
153Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52032949
154Pertussis_Homo sapiens_hsa051330.49995009
155Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48251053
156MAPK signaling pathway_Homo sapiens_hsa040100.48242119
157Rap1 signaling pathway_Homo sapiens_hsa040150.47619133
158ErbB signaling pathway_Homo sapiens_hsa040120.46698870
159Allograft rejection_Homo sapiens_hsa053300.46143759

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