BRD7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)5.09890222
2regulation of RNA export from nucleus (GO:0046831)4.20992643
3regulation of histone H3-K9 methylation (GO:0051570)4.17371057
4sister chromatid cohesion (GO:0007062)4.15366752
5ribosomal small subunit assembly (GO:0000028)4.09971707
6pre-miRNA processing (GO:0031054)3.92919331
7DNA strand elongation involved in DNA replication (GO:0006271)3.83692657
8telomere maintenance via semi-conservative replication (GO:0032201)3.78842411
9DNA unwinding involved in DNA replication (GO:0006268)3.78413554
10cotranslational protein targeting to membrane (GO:0006613)3.77368252
11chromosome organization involved in meiosis (GO:0070192)3.75029854
12protein targeting to ER (GO:0045047)3.74303854
13kinetochore organization (GO:0051383)3.73352724
14DNA strand elongation (GO:0022616)3.69732099
15heterochromatin organization (GO:0070828)3.68773479
16telomere maintenance via recombination (GO:0000722)3.68766683
17cellular protein complex disassembly (GO:0043624)3.67673190
18establishment of protein localization to endoplasmic reticulum (GO:0072599)3.62055320
19alternative mRNA splicing, via spliceosome (GO:0000380)3.61380912
20mitotic recombination (GO:0006312)3.60247571
21DNA replication initiation (GO:0006270)3.58983113
22DNA replication checkpoint (GO:0000076)3.56552484
23mitotic metaphase plate congression (GO:0007080)3.54038093
24maturation of SSU-rRNA (GO:0030490)3.46639556
25protein localization to kinetochore (GO:0034501)3.46042001
26protein complex disassembly (GO:0043241)3.44097958
27negative regulation of histone methylation (GO:0031061)3.43863330
28protein localization to endoplasmic reticulum (GO:0070972)3.40051406
29metaphase plate congression (GO:0051310)3.39160218
30mitotic sister chromatid cohesion (GO:0007064)3.38871701
31IMP metabolic process (GO:0046040)3.37411094
32mitotic chromosome condensation (GO:0007076)3.35346512
33meiotic chromosome segregation (GO:0045132)3.34264194
34protein localization to chromosome (GO:0034502)3.31944924
35positive regulation of chromosome segregation (GO:0051984)3.30948031
36CENP-A containing nucleosome assembly (GO:0034080)3.30724754
37establishment of chromosome localization (GO:0051303)3.28099346
38macromolecular complex disassembly (GO:0032984)3.26507338
39negative regulation of DNA repair (GO:0045738)3.25879760
40regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.24920439
41negative regulation of chromosome segregation (GO:0051985)3.24257940
42negative regulation of mitotic sister chromatid separation (GO:2000816)3.24131901
43negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.24131901
44negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.24131901
45chromatin remodeling at centromere (GO:0031055)3.24080800
46regulation of mitotic sister chromatid separation (GO:0010965)3.22916297
47regulation of mitotic sister chromatid segregation (GO:0033047)3.22916297
48regulation of sister chromatid segregation (GO:0033045)3.22916297
49mitotic spindle checkpoint (GO:0071174)3.21888703
50DNA replication-independent nucleosome assembly (GO:0006336)3.19104396
51DNA replication-independent nucleosome organization (GO:0034724)3.19104396
52negative regulation of DNA-dependent DNA replication (GO:2000104)3.16976256
53regulation of mitotic metaphase/anaphase transition (GO:0030071)3.15776184
54regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.15776184
55regulation of nucleobase-containing compound transport (GO:0032239)3.13746772
56viral transcription (GO:0019083)3.12813495
57positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.12537898
58positive regulation of mitotic sister chromatid separation (GO:1901970)3.12537898
59positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.12537898
60IMP biosynthetic process (GO:0006188)3.11988193
61attachment of spindle microtubules to kinetochore (GO:0008608)3.11433520
62V(D)J recombination (GO:0033151)3.08803237
63telomere maintenance via telomere lengthening (GO:0010833)3.08146523
64translational termination (GO:0006415)3.07463049
65regulation of centrosome cycle (GO:0046605)3.06700248
66nucleotide-excision repair, DNA gap filling (GO:0006297)3.05988733
67kinetochore assembly (GO:0051382)3.04887371
68nuclear pore complex assembly (GO:0051292)3.04252108
69positive regulation of histone methylation (GO:0031062)3.04029383
70protein localization to chromosome, centromeric region (GO:0071459)3.03764689
71histone H3-K9 demethylation (GO:0033169)3.01896893
72mRNA catabolic process (GO:0006402)3.01695418
73nuclear pore organization (GO:0006999)3.00858729
74positive regulation of histone H3-K4 methylation (GO:0051571)2.98566143
75negative regulation of cell killing (GO:0031342)2.96596887
76negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.96596887
77regulation of centriole replication (GO:0046599)2.96462449
78regulation of gene silencing by miRNA (GO:0060964)2.95857556
79mitotic nuclear envelope disassembly (GO:0007077)2.94405512
80monoubiquitinated protein deubiquitination (GO:0035520)2.90961903
81DNA replication-dependent nucleosome assembly (GO:0006335)2.85307953
82DNA replication-dependent nucleosome organization (GO:0034723)2.85307953
83ribosomal large subunit biogenesis (GO:0042273)2.84703656
84DNA topological change (GO:0006265)2.82455280
85ribosomal small subunit biogenesis (GO:0042274)2.81347818
86negative regulation of RNA splicing (GO:0033119)2.80659229
87histone exchange (GO:0043486)2.79757900
88mitotic sister chromatid segregation (GO:0000070)2.79128324
89positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.77508819
90telomere maintenance (GO:0000723)2.76586595
91telomere organization (GO:0032200)2.73622048
92nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.73423610
93negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.72371340
94translational elongation (GO:0006414)2.70946855
95regulation of sister chromatid cohesion (GO:0007063)2.66235614
96regulation of DNA endoreduplication (GO:0032875)2.65082282
97ATP-dependent chromatin remodeling (GO:0043044)2.64014114
98translational initiation (GO:0006413)2.63915822
99sister chromatid segregation (GO:0000819)2.63211690
100chromatin assembly or disassembly (GO:0006333)2.61609302
101RNA splicing, via transesterification reactions (GO:0000375)2.60889465
102mRNA splicing, via spliceosome (GO:0000398)2.60471008
103RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.60471008
104viral mRNA export from host cell nucleus (GO:0046784)2.60455473
105mitotic G2/M transition checkpoint (GO:0044818)2.59954889
106formation of translation preinitiation complex (GO:0001731)2.59106218
107membrane disassembly (GO:0030397)2.58805743
108nuclear envelope disassembly (GO:0051081)2.58805743
109spindle checkpoint (GO:0031577)2.58545609
110termination of RNA polymerase II transcription (GO:0006369)2.58162009
111ribonucleoprotein complex biogenesis (GO:0022613)2.57139374
112regulation of spindle organization (GO:0090224)2.56216169
113DNA duplex unwinding (GO:0032508)2.54918797
114spindle assembly checkpoint (GO:0071173)2.52252915
115DNA geometric change (GO:0032392)2.52158232
116megakaryocyte development (GO:0035855)2.52112901
117regulation of transcription from RNA polymerase I promoter (GO:0006356)2.51552838
118spliceosomal complex assembly (GO:0000245)2.51327956
119transcription-coupled nucleotide-excision repair (GO:0006283)2.51155895
120negative regulation of mRNA processing (GO:0050686)2.50277518
121DNA synthesis involved in DNA repair (GO:0000731)2.49634973
122pore complex assembly (GO:0046931)2.48747191
123RNA-dependent DNA replication (GO:0006278)2.48642739
124pseudouridine synthesis (GO:0001522)2.48023099
1253-UTR-mediated mRNA stabilization (GO:0070935)2.46865938
126spliceosomal snRNP assembly (GO:0000387)2.45878164
127exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.45400436
128SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.44241166
129regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.43074057
130regulation of chromosome segregation (GO:0051983)2.42964740
131positive regulation of protein import into nucleus, translocation (GO:0033160)2.42295481
132telomere maintenance via telomerase (GO:0007004)2.41581691
133viral life cycle (GO:0019058)2.41178224
134mitotic spindle assembly checkpoint (GO:0007094)2.40514036
135regulation of double-strand break repair via homologous recombination (GO:0010569)2.39787527
136mismatch repair (GO:0006298)2.39269988
137nuclear-transcribed mRNA catabolic process (GO:0000956)2.39264305
138protein K6-linked ubiquitination (GO:0085020)2.39150294
139ribosome biogenesis (GO:0042254)2.38179753
140negative regulation of mitotic sister chromatid segregation (GO:0033048)2.37420682
141negative regulation of sister chromatid segregation (GO:0033046)2.37420682

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.91984599
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.36592053
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.06241980
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.76542327
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.54059172
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.47762565
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.01562407
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.69320781
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.54651028
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.46164956
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.30894990
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.30417843
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.29674746
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.22779674
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.20916502
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.18087148
17AR_21909140_ChIP-Seq_LNCAP_Human2.17996766
18VDR_23849224_ChIP-Seq_CD4+_Human2.10978321
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.10203400
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08200765
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.05201931
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.03457162
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99781708
24BP1_19119308_ChIP-ChIP_Hs578T_Human1.98674881
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94333607
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.92185871
27CIITA_25753668_ChIP-Seq_RAJI_Human1.90349536
28XRN2_22483619_ChIP-Seq_HELA_Human1.88730723
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.85294171
30MYC_22102868_ChIP-Seq_BL_Human1.84960078
31SCL_19346495_ChIP-Seq_HPC-7_Human1.84688040
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.84218606
33* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.83461736
34FOXP3_21729870_ChIP-Seq_TREG_Human1.82876689
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.80974194
36FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.77568076
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77236192
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.76757775
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76202726
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75179886
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.72182861
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70728785
43ELK1_19687146_ChIP-ChIP_HELA_Human1.67878473
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67129714
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.66885646
46* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.66844835
47SPI1_23547873_ChIP-Seq_NB4_Human1.65704040
48* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.62074290
49KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.61069857
50KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.61069857
51KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.61069857
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60655033
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.58820744
54HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.54860324
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54291239
56MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.53007779
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.52961420
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.52878400
59DCP1A_22483619_ChIP-Seq_HELA_Human1.52581784
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.51716074
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.50313799
62IRF8_21731497_ChIP-ChIP_J774_Mouse1.46592224
63* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.46444559
64TTF2_22483619_ChIP-Seq_HELA_Human1.45293419
65E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.41332727
66NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40458946
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37875255
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.37087015
69MYB_21317192_ChIP-Seq_ERMYB_Mouse1.34920161
70SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.34684719
71VDR_21846776_ChIP-Seq_THP-1_Human1.33698324
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32819192
73STAT4_19710469_ChIP-ChIP_TH1__Mouse1.32500304
74TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.30387800
75GABP_19822575_ChIP-Seq_HepG2_Human1.28199032
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.25898753
77STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.24132626
78* FUS_26573619_Chip-Seq_HEK293_Human1.21835156
79* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21784410
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.20933813
81EWS_26573619_Chip-Seq_HEK293_Human1.20523922
82RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19969267
83* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19450023
84CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.19341137
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18838802
86TP63_19390658_ChIP-ChIP_HaCaT_Human1.17795714
87NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17042819
88MYB_26560356_Chip-Seq_TH2_Human1.17000970
89KDM5A_27292631_Chip-Seq_BREAST_Human1.14867040
90TFEB_21752829_ChIP-Seq_HELA_Human1.12560552
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11172264
92PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10397740
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10055903
94MYB_26560356_Chip-Seq_TH1_Human1.09571466
95POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09192284
96FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.07487202
97RUNX1_22412390_ChIP-Seq_EML_Mouse1.07175592
98MAF_26560356_Chip-Seq_TH1_Human1.06114254
99THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05028660
100GATA1_22025678_ChIP-Seq_K562_Human1.03030277
101MYC_18940864_ChIP-ChIP_HL60_Human1.02066291
102SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01008690
103UTX_26944678_Chip-Seq_JUKART_Human1.00860075
104NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98727381
105CHD1_26751641_Chip-Seq_LNCaP_Human0.98425790
106VDR_24763502_ChIP-Seq_THP-1_Human0.97561027
107CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96945574
108TCF3_18692474_ChIP-Seq_MESCs_Mouse0.96009344
109YY1_21170310_ChIP-Seq_MESCs_Mouse0.95739951
110SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95210551
111ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95159750
112CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94024299
113TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93882885
114SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93688938
115GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93602519
116SOX2_16153702_ChIP-ChIP_HESCs_Human0.91815841
117ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91220967
118ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91170287
119IRF8_27001747_Chip-Seq_BMDM_Mouse0.90684457
120GATA4_21415370_ChIP-Seq_HL-1_Mouse0.90493613
121CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90230728
122GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89602236
123KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89406668
124NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.88144418
125NANOG_16153702_ChIP-ChIP_HESCs_Human0.87547984
126RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87043912
127DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83443820
128SOX17_20123909_ChIP-Seq_XEN_Mouse0.80510830
129NANOG_21062744_ChIP-ChIP_HESCs_Human0.79166617
130KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.71899942
131FLI1_27457419_Chip-Seq_LIVER_Mouse0.70485614
132SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68675449
133REST_19997604_ChIP-ChIP_NEURONS_Mouse0.65410743
134FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.64755122
135TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.64426363

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.22888675
2MP0010094_abnormal_chromosome_stability3.61076043
3MP0003693_abnormal_embryo_hatching3.47873313
4MP0009379_abnormal_foot_pigmentation3.30270968
5MP0002396_abnormal_hematopoietic_system3.07407181
6MP0003077_abnormal_cell_cycle3.01813060
7MP0003111_abnormal_nucleus_morphology2.94242703
8MP0008007_abnormal_cellular_replicative2.83997046
9MP0003890_abnormal_embryonic-extraembry2.76291145
10MP0008057_abnormal_DNA_replication2.66275333
11MP0004957_abnormal_blastocyst_morpholog2.61077039
12MP0006054_spinal_hemorrhage2.47060378
13MP0003787_abnormal_imprinting2.27334871
14MP0008058_abnormal_DNA_repair2.20840246
15MP0001835_abnormal_antigen_presentation2.06346416
16MP0004808_abnormal_hematopoietic_stem1.98197325
17MP0002009_preneoplasia1.93293976
18MP0003567_abnormal_fetal_cardiomyocyte1.85712729
19MP0003121_genomic_imprinting1.69693296
20MP0004185_abnormal_adipocyte_glucose1.62498745
21MP0003937_abnormal_limbs/digits/tail_de1.60479552
22MP0003136_yellow_coat_color1.60396511
23MP0002398_abnormal_bone_marrow1.59212510
24MP0000350_abnormal_cell_proliferation1.57992505
25MP0003763_abnormal_thymus_physiology1.56155634
26MP0005076_abnormal_cell_differentiation1.55037133
27MP0001730_embryonic_growth_arrest1.53658276
28MP0002160_abnormal_reproductive_system1.53284467
29MP0005397_hematopoietic_system_phenotyp1.52324450
30MP0001545_abnormal_hematopoietic_system1.52324450
31MP0010307_abnormal_tumor_latency1.50635738
32MP0002697_abnormal_eye_size1.48553839
33MP0000490_abnormal_crypts_of1.48330528
34MP0009333_abnormal_splenocyte_physiolog1.46644808
35MP0000428_abnormal_craniofacial_morphol1.43516765
36MP0005671_abnormal_response_to1.42794693
37MP0003221_abnormal_cardiomyocyte_apopto1.41463559
38MP0001286_abnormal_eye_development1.41404149
39MP0008932_abnormal_embryonic_tissue1.41002400
40MP0005174_abnormal_tail_pigmentation1.40893209
41MP0009672_abnormal_birth_weight1.40891343
42MP0001929_abnormal_gametogenesis1.39890765
43MP0003950_abnormal_plasma_membrane1.38698771
44MP0000703_abnormal_thymus_morphology1.37403171
45MP0000566_synostosis1.35998587
46MP0002166_altered_tumor_susceptibility1.35676300
47MP0003718_maternal_effect1.34185435
48MP0001145_abnormal_male_reproductive1.32137546
49MP0002722_abnormal_immune_system1.28031157
50MP0000689_abnormal_spleen_morphology1.26986792
51MP0009785_altered_susceptibility_to1.26951387
52MP0002452_abnormal_antigen_presenting1.24746259
53MP0003941_abnormal_skin_development1.24012660
54MP0010030_abnormal_orbit_morphology1.22837837
55MP0002429_abnormal_blood_cell1.21503123
56MP0008877_abnormal_DNA_methylation1.21211171
57MP0000716_abnormal_immune_system1.21061754
58MP0002019_abnormal_tumor_incidence1.20575271
59MP0001800_abnormal_humoral_immune1.19905633
60MP0002092_abnormal_eye_morphology1.19577046
61MP0002420_abnormal_adaptive_immunity1.18065170
62MP0009697_abnormal_copulation1.18046537
63MP0009703_decreased_birth_body1.17502438
64MP0000313_abnormal_cell_death1.17125657
65MP0001819_abnormal_immune_cell1.16853497
66MP0005380_embryogenesis_phenotype1.16681112
67MP0001672_abnormal_embryogenesis/_devel1.16681112
68MP0003646_muscle_fatigue1.15534755
69MP0000653_abnormal_sex_gland1.15377950
70MP0001915_intracranial_hemorrhage1.14697945
71MP0003943_abnormal_hepatobiliary_system1.14301373
72MP0003786_premature_aging1.13995981
73MP0001849_ear_inflammation1.12644275
74MP0004084_abnormal_cardiac_muscle1.11571383
75MP0003984_embryonic_growth_retardation1.10622996
76MP0005025_abnormal_response_to1.10080770
77MP0000569_abnormal_digit_pigmentation1.07246116
78MP0000465_gastrointestinal_hemorrhage1.07002600
79MP0002006_tumorigenesis1.06803184
80MP0002723_abnormal_immune_serum1.06748882
81MP0002638_abnormal_pupillary_reflex1.06277997
82MP0004147_increased_porphyrin_level1.05609770
83MP0002088_abnormal_embryonic_growth/wei1.05585322
84MP0001697_abnormal_embryo_size1.05110029
85MP0009278_abnormal_bone_marrow1.04953140
86MP0000685_abnormal_immune_system1.03669607
87MP0000631_abnormal_neuroendocrine_gland1.03075274
88MP0005464_abnormal_platelet_physiology1.02324399
89MP0010234_abnormal_vibrissa_follicle1.01661144
90MP0002080_prenatal_lethality1.01415959
91MP0003315_abnormal_perineum_morphology1.00204296
92MP0000733_abnormal_muscle_development0.99539191
93MP0005171_absent_coat_pigmentation0.99052026
94MP0010630_abnormal_cardiac_muscle0.98287539
95MP0002163_abnormal_gland_morphology0.97931517
96MP0002405_respiratory_system_inflammati0.97460435
97MP0002419_abnormal_innate_immunity0.97264067
98MP0003122_maternal_imprinting0.97091156
99MP0002095_abnormal_skin_pigmentation0.95943298
100MP0003698_abnormal_male_reproductive0.94609580
101MP0001853_heart_inflammation0.93497314
102MP0002148_abnormal_hypersensitivity_rea0.93332191
103MP0003119_abnormal_digestive_system0.93301807
104MP0010678_abnormal_skin_adnexa0.92853113
105MP0002132_abnormal_respiratory_system0.91981679
106MP0005000_abnormal_immune_tolerance0.91872977
107MP0003861_abnormal_nervous_system0.91690609
108MP0003828_pulmonary_edema0.91477910
109MP0002233_abnormal_nose_morphology0.91356786
110MP0005408_hypopigmentation0.91298822
111MP0008438_abnormal_cutaneous_collagen0.90406177
112MP0008995_early_reproductive_senescence0.89509504
113MP0003935_abnormal_craniofacial_develop0.89256580
114MP0000383_abnormal_hair_follicle0.88003524
115MP0003656_abnormal_erythrocyte_physiolo0.87968978
116MP0010352_gastrointestinal_tract_polyps0.87287260
117MP0010155_abnormal_intestine_physiology0.86945031
118MP0003279_aneurysm0.86368218
119MP0002085_abnormal_embryonic_tissue0.86094642
120MP0010368_abnormal_lymphatic_system0.86050891
121MP0004197_abnormal_fetal_growth/weight/0.85738320
122MP0009053_abnormal_anal_canal0.85576966
123MP0001958_emphysema0.84951689
124MP0005389_reproductive_system_phenotype0.84907515
125MP0003699_abnormal_female_reproductive0.84528591
126MP0008789_abnormal_olfactory_epithelium0.83912172
127MP0002086_abnormal_extraembryonic_tissu0.83703418
128MP0002084_abnormal_developmental_patter0.82601117
129MP0000432_abnormal_head_morphology0.81369850
130MP0003938_abnormal_ear_development0.81168088
131MP0002111_abnormal_tail_morphology0.80977608
132MP0002210_abnormal_sex_determination0.80765340
133MP0005075_abnormal_melanosome_morpholog0.79105465
134MP0002938_white_spotting0.78632060
135MP0003123_paternal_imprinting0.77181283
136MP0002075_abnormal_coat/hair_pigmentati0.76930773
137MP0001186_pigmentation_phenotype0.76531713
138MP0002106_abnormal_muscle_physiology0.76120902
139MP0003385_abnormal_body_wall0.75933028
140MP0000858_altered_metastatic_potential0.75578754
141MP0001119_abnormal_female_reproductive0.75571898
142MP0005387_immune_system_phenotype0.73775979
143MP0001790_abnormal_immune_system0.73775979
144MP0005379_endocrine/exocrine_gland_phen0.73716681
145MP0003436_decreased_susceptibility_to0.73685298
146MP0000749_muscle_degeneration0.73283338
147MP0004782_abnormal_surfactant_physiolog0.72447951
148MP0000343_altered_response_to0.71994179
149MP0001293_anophthalmia0.71274607
150MP0002161_abnormal_fertility/fecundity0.67840286
151MP0001188_hyperpigmentation0.67460303
152MP0003936_abnormal_reproductive_system0.67333873
153MP0003755_abnormal_palate_morphology0.64629142
154MP0001346_abnormal_lacrimal_gland0.64532376
155MP0001324_abnormal_eye_pigmentation0.62455677
156MP0005391_vision/eye_phenotype0.61960677
157MP0005257_abnormal_intraocular_pressure0.61507123
158MP0002796_impaired_skin_barrier0.61259842

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)3.80649465
2Abnormality of cells of the erythroid lineage (HP:0012130)3.72533568
3Chromsome breakage (HP:0040012)3.52147362
4Thyroiditis (HP:0100646)3.44793512
5Thrombocytosis (HP:0001894)3.27182006
6Nephroblastoma (Wilms tumor) (HP:0002667)3.20133175
7Abnormality of cochlea (HP:0000375)3.18779872
8Reticulocytopenia (HP:0001896)3.17125542
9Severe combined immunodeficiency (HP:0004430)3.16774017
10Oligodactyly (hands) (HP:0001180)3.08684021
11Chromosomal breakage induced by crosslinking agents (HP:0003221)2.97051894
12Combined immunodeficiency (HP:0005387)2.96195089
13Embryonal renal neoplasm (HP:0011794)2.96004661
14Hepatoblastoma (HP:0002884)2.86660407
15Multiple enchondromatosis (HP:0005701)2.83920929
16Abnormality of chromosome stability (HP:0003220)2.81785648
17Birth length less than 3rd percentile (HP:0003561)2.79928111
18Myelodysplasia (HP:0002863)2.75117146
19Abnormality of the anterior horn cell (HP:0006802)2.74031290
20Degeneration of anterior horn cells (HP:0002398)2.74031290
21Meckel diverticulum (HP:0002245)2.70067865
22Papillary thyroid carcinoma (HP:0002895)2.69457912
23Diastasis recti (HP:0001540)2.68628834
24Aplastic anemia (HP:0001915)2.65310455
25Acute myeloid leukemia (HP:0004808)2.64976536
26Abnormality of the preputium (HP:0100587)2.64958290
27Duplication of thumb phalanx (HP:0009942)2.56878003
28Leukocytosis (HP:0001974)2.49493212
29Pallor (HP:0000980)2.47614581
30Increased nuchal translucency (HP:0010880)2.46934886
31Abnormality of the ileum (HP:0001549)2.44146697
32T lymphocytopenia (HP:0005403)2.43860265
33Morphological abnormality of the inner ear (HP:0011390)2.43645008
34Missing ribs (HP:0000921)2.42079674
35Recurrent viral infections (HP:0004429)2.39064624
36Rhabdomyosarcoma (HP:0002859)2.38741381
37Abnormality of eosinophils (HP:0001879)2.37684873
38Elevated erythrocyte sedimentation rate (HP:0003565)2.35933781
39Abnormality of DNA repair (HP:0003254)2.35310506
40Aplasia/Hypoplasia of the sternum (HP:0006714)2.34764530
41Absent radius (HP:0003974)2.33703628
42Agnosia (HP:0010524)2.33587053
43Abnormality of T cell number (HP:0011839)2.33120784
44Ectopic kidney (HP:0000086)2.31664777
45Short 4th metacarpal (HP:0010044)2.31101953
46Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.31101953
47Volvulus (HP:0002580)2.31083356
48Abnormal number of incisors (HP:0011064)2.29280943
49Absent forearm bone (HP:0003953)2.27390848
50Aplasia involving forearm bones (HP:0009822)2.27390848
51Selective tooth agenesis (HP:0001592)2.24243823
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.22891605
53Embryonal neoplasm (HP:0002898)2.22802153
54Triphalangeal thumb (HP:0001199)2.22026952
55Recurrent abscess formation (HP:0002722)2.20900397
56Subaortic stenosis (HP:0001682)2.20018036
57Abnormality of the left ventricular outflow tract (HP:0011103)2.20018036
58Low anterior hairline (HP:0000294)2.19332195
59Patellar aplasia (HP:0006443)2.19041781
60Amaurosis fugax (HP:0100576)2.17587138
61Neoplasm of the adrenal cortex (HP:0100641)2.13268211
62Abnormality of the fingertips (HP:0001211)2.11821460
63Rectovaginal fistula (HP:0000143)2.11708024
64Rectal fistula (HP:0100590)2.11708024
65Breast hypoplasia (HP:0003187)2.11533757
66Absent thumb (HP:0009777)2.11286636
67Medulloblastoma (HP:0002885)2.11026861
68Oligodactyly (HP:0012165)2.10909116
69Abnormality of chromosome segregation (HP:0002916)2.10477566
70Lymphoma (HP:0002665)2.10438869
71Abnormality of the labia minora (HP:0012880)2.09681057
72Clubbing of toes (HP:0100760)2.09680455
73Hypochromic anemia (HP:0001931)2.09409010
74Hyperinsulinemic hypoglycemia (HP:0000825)2.08760146
75Septo-optic dysplasia (HP:0100842)2.07562645
76Small intestinal stenosis (HP:0012848)2.07422019
77Duodenal stenosis (HP:0100867)2.07422019
78Abnormality of the duodenum (HP:0002246)2.06661726
79Overlapping toe (HP:0001845)2.06408524
80Petechiae (HP:0000967)2.06147951
81Myositis (HP:0100614)2.05198045
82Duplicated collecting system (HP:0000081)2.04022642
83Spinal cord lesions (HP:0100561)2.03341123
84Syringomyelia (HP:0003396)2.03341123
85Anophthalmia (HP:0000528)2.02211358
86Abnormality of B cell number (HP:0010975)2.01952142
87B lymphocytopenia (HP:0010976)2.01952142
88Bone marrow hypocellularity (HP:0005528)2.01214651
89Abnormal lung lobation (HP:0002101)2.01182920
90Aplasia/Hypoplasia of the patella (HP:0006498)2.00443495
91Abnormality of the heme biosynthetic pathway (HP:0010472)1.99578958
92Obsessive-compulsive behavior (HP:0000722)1.96779509
93Gastrointestinal carcinoma (HP:0002672)1.96341542
94Malignant gastrointestinal tract tumors (HP:0006749)1.96341542
95Capillary hemangiomas (HP:0005306)1.96231120
96Abnormality of the carotid arteries (HP:0005344)1.96158388
97Neoplasm of the colon (HP:0100273)1.95595317
98Cleft eyelid (HP:0000625)1.94871658
99Recurrent bacterial skin infections (HP:0005406)1.94674903
100Macrocytic anemia (HP:0001972)1.94298166
101Partial duplication of thumb phalanx (HP:0009944)1.93241480
102Intestinal fistula (HP:0100819)1.91845346
103Neoplasm of striated muscle (HP:0009728)1.91815399
104Sloping forehead (HP:0000340)1.91752427
105Cafe-au-lait spot (HP:0000957)1.91644441
106Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90432361
107Heterotopia (HP:0002282)1.89630690
108Broad thumb (HP:0011304)1.89454301
109Abnormality of T cells (HP:0002843)1.89015890
110Asymmetry of the thorax (HP:0001555)1.88929954
111Progressive external ophthalmoplegia (HP:0000590)1.88629004
112Abnormality of the lacrimal duct (HP:0011481)1.87949037
113Biliary tract neoplasm (HP:0100574)1.87857198
114Impulsivity (HP:0100710)1.87748605
115Anal stenosis (HP:0002025)1.87225603
116Facial cleft (HP:0002006)1.87127401
117Urethral obstruction (HP:0000796)1.87008889
118Facial hemangioma (HP:0000329)1.86074035
119Proximal placement of thumb (HP:0009623)1.85793270
120Horseshoe kidney (HP:0000085)1.85576814
121Pancreatic islet-cell hyperplasia (HP:0004510)1.83935338
122Eosinophilia (HP:0001880)1.82064375
123Prominent nose (HP:0000448)1.81943893
124Uterine leiomyosarcoma (HP:0002891)1.81782253
125Leiomyosarcoma (HP:0100243)1.81782253
126Choanal atresia (HP:0000453)1.81610690
127Abnormality of the renal collecting system (HP:0004742)1.81440725
128Colon cancer (HP:0003003)1.81020106
129Short middle phalanx of the 5th finger (HP:0004220)1.80736107
130Abnormality of the nasal septum (HP:0000419)1.80499063
131IgM deficiency (HP:0002850)1.80158618
132Recurrent fungal infections (HP:0002841)1.78691269
133Abnormality of the parietal bone (HP:0002696)1.78081828
134Neoplasm of the oral cavity (HP:0100649)1.76870189
135Retrobulbar optic neuritis (HP:0100654)1.76757847
136Optic neuritis (HP:0100653)1.76757847
137Premature graying of hair (HP:0002216)1.75730584
138Tracheoesophageal fistula (HP:0002575)1.75481430
139Enlarged penis (HP:0000040)1.75164379
140Optic nerve coloboma (HP:0000588)1.75137905
141Vaginal fistula (HP:0004320)1.74967123
142Nasolacrimal duct obstruction (HP:0000579)1.74948516
143Deviation of the thumb (HP:0009603)1.73600978
144Intestinal atresia (HP:0011100)1.73563763
145Abnormality of the nasolacrimal system (HP:0000614)1.73244634
14611 pairs of ribs (HP:0000878)1.72888792
147Esophageal atresia (HP:0002032)1.72816815
148Disinhibition (HP:0000734)1.72812835
149Pulmonary artery stenosis (HP:0004415)1.72366889
150Atresia of the external auditory canal (HP:0000413)1.72153957
151High pitched voice (HP:0001620)1.71957545
152IgG deficiency (HP:0004315)1.71075861
153Supernumerary bones of the axial skeleton (HP:0009144)1.69797300
154Long eyelashes (HP:0000527)1.69476422
155Chronic otitis media (HP:0000389)1.69386136
156Overriding aorta (HP:0002623)1.67310868
157Recurrent bronchitis (HP:0002837)1.67304904
158Long clavicles (HP:0000890)1.65880579
159Aortic regurgitation (HP:0001659)1.65765319
160Hyperacusis (HP:0010780)1.65503874
161Pulmonary fibrosis (HP:0002206)1.65211348
162Panhypogammaglobulinemia (HP:0003139)1.64241542
163Cellulitis (HP:0100658)1.63658164
164Osteomyelitis (HP:0002754)1.63630805
165Mediastinal lymphadenopathy (HP:0100721)1.63430192
166Abnormality of cells of the lymphoid lineage (HP:0012140)1.63042897
167Autoimmune thrombocytopenia (HP:0001973)1.62290857
168Lymphopenia (HP:0001888)1.62204476
169Broad palm (HP:0001169)1.61986619

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK3.89029826
2CDC73.87246901
3IRAK42.84297381
4MKNK12.55313833
5BUB12.52953113
6CDK122.31566056
7STK42.26868200
8MKNK22.19281044
9STK102.15758662
10WEE12.15427931
11KIT2.11518911
12NME21.98443919
13VRK11.97817656
14TYRO31.96334840
15NEK21.93411079
16MAP4K11.91308115
17SRPK11.83135281
18CAMK1G1.82911351
19FLT31.74514540
20TAF11.70137147
21TTK1.67649060
22MAP3K101.66989846
23EEF2K1.64880810
24PLK41.61154159
25TGFBR21.60378646
26FGFR21.60252925
27INSRR1.53607846
28CLK11.50646572
29EIF2AK11.44977180
30CDK191.43209752
31TXK1.43132845
32AURKB1.40250402
33CDK41.40146046
34FGFR31.39782966
35RPS6KA41.37242534
36ATR1.36441066
37PLK11.33880149
38STK241.25210832
39CSF1R1.22885206
40EIF2AK21.22141990
41PIM11.21653125
42ZAK1.21127011
43CDK71.16491726
44MST41.16426061
45PASK1.16060153
46WNK11.14693251
47TTN1.13519558
48BMPR1B1.12272797
49JAK31.09026531
50PLK31.08631355
51CDK81.07788537
52RPS6KB21.06301962
53BTK1.05883559
54IKBKE1.04443611
55OBSCN1.03319075
56NLK1.02995338
57LRRK21.02378876
58CDK31.02146956
59TEC0.99330815
60FGFR10.99284185
61MAP3K130.98681493
62ZAP700.98607884
63CHEK10.98065658
64FGFR40.95730716
65CHUK0.95312659
66CDK60.94976556
67TRPM70.94816083
68TLK10.94045237
69DYRK30.91793130
70TSSK60.91130262
71ATM0.90335753
72CSNK1E0.90254996
73CAMK1D0.90017729
74CHEK20.87446372
75BRSK10.85969724
76SMG10.85585334
77ILK0.85432531
78YES10.84391079
79NUAK10.83936843
80MAP3K80.83632863
81MAP2K30.83126089
82PKN20.82641307
83STK30.82470982
84STK38L0.82217943
85TNIK0.81164541
86PBK0.78780430
87LATS10.78411001
88GRK60.76965433
89ACVR1B0.76802483
90TGFBR10.76784832
91TBK10.74446186
92WNK40.74004814
93BRSK20.72644224
94MAP3K140.72020090
95EIF2AK30.71065826
96NEK90.70216807
97PIM20.69780495
98KSR10.68288968
99MAP3K60.66935793
100PAK40.65892565
101RPS6KA50.64239398
102SGK10.63920988
103IKBKB0.63612500
104TYK20.62099532
105MARK30.61614394
106KSR20.59869399
107CDK20.59343331
108MAPKAPK20.59115513
109CSNK2A10.58890255
110PRKDC0.58765080
111RPS6KB10.57628907
112NEK10.55505726
113MAPKAPK50.55388913
114MAP2K20.54688235
115LYN0.53977585
116MAP3K20.52520537
117JAK10.50151489
118STK110.50059578
119SYK0.49930813
120PDK20.49532740
121MAPK140.49399537
122PDGFRB0.49030907
123MELK0.48784983
124LCK0.48322152
125CSNK2A20.48240487
126CDK10.47999317
127MET0.46729678
128CDK90.46680289
129BRD40.45185173
130CSNK1G10.43912927
131GRK70.43822051
132DMPK0.43478102
133BRAF0.43449502
134MAP3K90.43097353
135STK160.42699077
136GSK3B0.42120148
137ITK0.42088692
138MAPK110.41766247
139CSNK1A1L0.41598515
140NME10.40214253
141MAP3K40.40014800
142ALK0.39915226
143FGR0.38122472
144ICK0.37191434
145MTOR0.36438976
146AKT10.35018717
147FRK0.32737406

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.30180653
2Mismatch repair_Homo sapiens_hsa034303.56576481
3Ribosome_Homo sapiens_hsa030103.01013264
4RNA polymerase_Homo sapiens_hsa030202.95823852
5Homologous recombination_Homo sapiens_hsa034402.94843579
6Spliceosome_Homo sapiens_hsa030402.87508809
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.73078714
8Base excision repair_Homo sapiens_hsa034102.57041261
9Non-homologous end-joining_Homo sapiens_hsa034502.42958783
10Cell cycle_Homo sapiens_hsa041102.41541510
11RNA transport_Homo sapiens_hsa030132.36004891
12Nucleotide excision repair_Homo sapiens_hsa034202.28753342
13RNA degradation_Homo sapiens_hsa030182.18100847
14Fanconi anemia pathway_Homo sapiens_hsa034602.11619772
15One carbon pool by folate_Homo sapiens_hsa006702.01219413
16Proteasome_Homo sapiens_hsa030501.99770535
17Pyrimidine metabolism_Homo sapiens_hsa002401.94123149
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.83833196
19Basal transcription factors_Homo sapiens_hsa030221.81669435
20Primary immunodeficiency_Homo sapiens_hsa053401.70309887
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68469529
22Herpes simplex infection_Homo sapiens_hsa051681.52712280
23Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.48318208
24mRNA surveillance pathway_Homo sapiens_hsa030151.47368866
25Antigen processing and presentation_Homo sapiens_hsa046121.40829333
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.32131186
27p53 signaling pathway_Homo sapiens_hsa041151.29827552
28Leishmaniasis_Homo sapiens_hsa051401.27948603
29Wnt signaling pathway_Homo sapiens_hsa043101.23585135
30Epstein-Barr virus infection_Homo sapiens_hsa051691.17634812
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.17533705
32Viral myocarditis_Homo sapiens_hsa054161.14945689
33Measles_Homo sapiens_hsa051621.14317473
34Systemic lupus erythematosus_Homo sapiens_hsa053221.12604717
35Purine metabolism_Homo sapiens_hsa002301.10039037
36Hematopoietic cell lineage_Homo sapiens_hsa046401.05658254
37Legionellosis_Homo sapiens_hsa051341.00912327
38Viral carcinogenesis_Homo sapiens_hsa052030.98878793
39Hedgehog signaling pathway_Homo sapiens_hsa043400.93931871
40NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93184415
41Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91185825
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90476631
43Intestinal immune network for IgA production_Homo sapiens_hsa046720.89985269
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89353549
45Small cell lung cancer_Homo sapiens_hsa052220.89026748
46HTLV-I infection_Homo sapiens_hsa051660.88949199
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85699900
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80708377
49Notch signaling pathway_Homo sapiens_hsa043300.80467831
50Hippo signaling pathway_Homo sapiens_hsa043900.73359896
51Endometrial cancer_Homo sapiens_hsa052130.72777801
52MicroRNAs in cancer_Homo sapiens_hsa052060.72388062
53Graft-versus-host disease_Homo sapiens_hsa053320.72282185
54Dorso-ventral axis formation_Homo sapiens_hsa043200.71170675
55Hepatitis B_Homo sapiens_hsa051610.71021003
56Chronic myeloid leukemia_Homo sapiens_hsa052200.69722511
57Apoptosis_Homo sapiens_hsa042100.69610894
58B cell receptor signaling pathway_Homo sapiens_hsa046620.68835721
59Influenza A_Homo sapiens_hsa051640.68766174
60Thyroid cancer_Homo sapiens_hsa052160.66450247
61Toll-like receptor signaling pathway_Homo sapiens_hsa046200.66222357
62Toxoplasmosis_Homo sapiens_hsa051450.66185001
63Allograft rejection_Homo sapiens_hsa053300.64160209
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63033080
65Huntingtons disease_Homo sapiens_hsa050160.62434422
66Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62433145
67Lysine degradation_Homo sapiens_hsa003100.62116102
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.61363293
69Malaria_Homo sapiens_hsa051440.59745564
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.59582426
71mTOR signaling pathway_Homo sapiens_hsa041500.59197851
72Parkinsons disease_Homo sapiens_hsa050120.59008930
73Adherens junction_Homo sapiens_hsa045200.58900983
74Osteoclast differentiation_Homo sapiens_hsa043800.57050495
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.56365558
76Pertussis_Homo sapiens_hsa051330.53729290
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52366476
78Renal cell carcinoma_Homo sapiens_hsa052110.52350347
79Folate biosynthesis_Homo sapiens_hsa007900.50414090
80Acute myeloid leukemia_Homo sapiens_hsa052210.50330324
81Pathways in cancer_Homo sapiens_hsa052000.49637377
82Shigellosis_Homo sapiens_hsa051310.47852189
83Pancreatic cancer_Homo sapiens_hsa052120.47312178
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46477627
85ErbB signaling pathway_Homo sapiens_hsa040120.46454804
86Propanoate metabolism_Homo sapiens_hsa006400.45586952
87Vitamin digestion and absorption_Homo sapiens_hsa049770.44760131
88Tuberculosis_Homo sapiens_hsa051520.44526569
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43720624
90Prostate cancer_Homo sapiens_hsa052150.42596164
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42381343
92Protein export_Homo sapiens_hsa030600.41483984
93Asthma_Homo sapiens_hsa053100.41323990
94Colorectal cancer_Homo sapiens_hsa052100.41184188
95Pentose phosphate pathway_Homo sapiens_hsa000300.40934667
96Selenocompound metabolism_Homo sapiens_hsa004500.40627519
97Basal cell carcinoma_Homo sapiens_hsa052170.40383528
98Prolactin signaling pathway_Homo sapiens_hsa049170.40141136
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39944623
100Choline metabolism in cancer_Homo sapiens_hsa052310.39852740
101Glutathione metabolism_Homo sapiens_hsa004800.38754559
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37944076
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37552517
104T cell receptor signaling pathway_Homo sapiens_hsa046600.37027223
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36894050
106Tight junction_Homo sapiens_hsa045300.35749074
107Platelet activation_Homo sapiens_hsa046110.35536634
108Inositol phosphate metabolism_Homo sapiens_hsa005620.34589478
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34070957
110Pyruvate metabolism_Homo sapiens_hsa006200.33894477
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33275218
112Non-small cell lung cancer_Homo sapiens_hsa052230.33160130
113Salmonella infection_Homo sapiens_hsa051320.32838120
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32023401
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31817603
116Oocyte meiosis_Homo sapiens_hsa041140.30632657
117FoxO signaling pathway_Homo sapiens_hsa040680.29372020
118Glioma_Homo sapiens_hsa052140.28626201
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28269319
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.27716703
121Ether lipid metabolism_Homo sapiens_hsa005650.27340332
122TGF-beta signaling pathway_Homo sapiens_hsa043500.26463910
123Melanogenesis_Homo sapiens_hsa049160.25708092
124HIF-1 signaling pathway_Homo sapiens_hsa040660.25150903
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23972233
126Insulin signaling pathway_Homo sapiens_hsa049100.23800314
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23693190
128TNF signaling pathway_Homo sapiens_hsa046680.23003633
129Thyroid hormone synthesis_Homo sapiens_hsa049180.22962039
130Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19268393
131Bladder cancer_Homo sapiens_hsa052190.18061168
132Phosphatidylinositol signaling system_Homo sapiens_hsa040700.17899752
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.17127574
134Glucagon signaling pathway_Homo sapiens_hsa049220.14998702
135Proteoglycans in cancer_Homo sapiens_hsa052050.14861665
136Fat digestion and absorption_Homo sapiens_hsa049750.14571718
137Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.14038138
138Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13499343
139Type II diabetes mellitus_Homo sapiens_hsa049300.10370402
140Fatty acid metabolism_Homo sapiens_hsa012120.07995112
141Steroid biosynthesis_Homo sapiens_hsa001000.05490402
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.05392358

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