BRD7P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cornea development in camera-type eye (GO:0061303)8.86468080
2regulation of timing of cell differentiation (GO:0048505)5.90043096
3behavioral response to nicotine (GO:0035095)5.58297220
4establishment of protein localization to mitochondrial membrane (GO:0090151)5.37160442
5regulation of development, heterochronic (GO:0040034)5.31233248
6hindbrain development (GO:0030902)4.82454189
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.72116639
8ATP synthesis coupled proton transport (GO:0015986)4.55216297
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.55216297
10positive regulation of cell fate commitment (GO:0010455)4.49798391
11GTP biosynthetic process (GO:0006183)4.39673214
12astrocyte differentiation (GO:0048708)4.09264137
13pyrimidine nucleobase catabolic process (GO:0006208)4.05374410
14dorsal/ventral axis specification (GO:0009950)3.96645290
15pituitary gland development (GO:0021983)3.86144716
16UTP biosynthetic process (GO:0006228)3.85831743
17DNA deamination (GO:0045006)3.84000037
18UTP metabolic process (GO:0046051)3.83759227
19CTP metabolic process (GO:0046036)3.77861314
20CTP biosynthetic process (GO:0006241)3.77861314
21chaperone-mediated protein transport (GO:0072321)3.64538110
22urate metabolic process (GO:0046415)3.61803207
23photoreceptor cell development (GO:0042461)3.59330439
24negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.58461897
25nucleobase catabolic process (GO:0046113)3.52063920
26positive regulation of neuroblast proliferation (GO:0002052)3.48034822
27pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.43168050
28pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.42409802
29ribosomal small subunit biogenesis (GO:0042274)3.42349772
30translational termination (GO:0006415)3.40468855
31viral transcription (GO:0019083)3.39461414
32artery development (GO:0060840)3.38826032
33dendritic spine morphogenesis (GO:0060997)3.35074920
34regulation of hexokinase activity (GO:1903299)3.31675761
35regulation of glucokinase activity (GO:0033131)3.31675761
36lymphangiogenesis (GO:0001946)3.28475569
37regulation of cell fate specification (GO:0042659)3.26627457
38signal transduction involved in regulation of gene expression (GO:0023019)3.21658310
39glandular epithelial cell differentiation (GO:0002067)3.20145092
40cell proliferation in forebrain (GO:0021846)3.18709654
41regulation of nuclear cell cycle DNA replication (GO:0033262)3.16021259
42pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.15705398
43eye photoreceptor cell development (GO:0042462)3.15032618
44ribosomal small subunit assembly (GO:0000028)3.14666040
45male meiosis I (GO:0007141)3.12503417
46pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.07273167
47substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.07253541
48substrate-independent telencephalic tangential migration (GO:0021826)3.07253541
49neuron fate commitment (GO:0048663)3.06322940
50tryptophan catabolic process (GO:0006569)3.05329618
51indole-containing compound catabolic process (GO:0042436)3.05329618
52indolalkylamine catabolic process (GO:0046218)3.05329618
53spinal cord association neuron differentiation (GO:0021527)3.04077981
54epithelial cilium movement (GO:0003351)3.03171839
55mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.02394562
56RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.01905501
57tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.01905501
58purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.00008494
593-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.00008494
60purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.95971636
61spinal cord motor neuron differentiation (GO:0021522)2.91857653
62piRNA metabolic process (GO:0034587)2.91137715
63nucleoside diphosphate phosphorylation (GO:0006165)2.90050814
64electron transport chain (GO:0022900)2.88174272
65respiratory electron transport chain (GO:0022904)2.87370029
66purine nucleoside triphosphate biosynthetic process (GO:0009145)2.86785244
67gonadal mesoderm development (GO:0007506)2.86610095
68sulfation (GO:0051923)2.85810534
69regulation of cell fate commitment (GO:0010453)2.80914997
70ribonucleoside triphosphate biosynthetic process (GO:0009201)2.80104994
71SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.72866740
72retinal ganglion cell axon guidance (GO:0031290)2.72666537
73cell differentiation in spinal cord (GO:0021515)2.72582939
74translational elongation (GO:0006414)2.71930063
75positive regulation of dendritic spine morphogenesis (GO:0061003)2.71094959
76regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.70054498
77cotranslational protein targeting to membrane (GO:0006613)2.69531323
78cullin deneddylation (GO:0010388)2.68958987
79sequestering of actin monomers (GO:0042989)2.68407236
80regulation of transcription involved in cell fate commitment (GO:0060850)2.68284007
81glandular epithelial cell development (GO:0002068)2.68264523
82protein targeting to ER (GO:0045047)2.65827143
83pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.63086168
84platelet dense granule organization (GO:0060155)2.62326168
85transmission of nerve impulse (GO:0019226)2.60865361
86indolalkylamine metabolic process (GO:0006586)2.59888992
87somite development (GO:0061053)2.59400997
88positive regulation of uterine smooth muscle contraction (GO:0070474)2.58370093
89regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.56955863
90tryptophan metabolic process (GO:0006568)2.52933910
91establishment of protein localization to endoplasmic reticulum (GO:0072599)2.51592365
92synapsis (GO:0007129)2.50756595
93ATP biosynthetic process (GO:0006754)2.50592191
94cellular protein complex disassembly (GO:0043624)2.50317452
95pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.50075440
96cellular response to cholesterol (GO:0071397)2.49612233
97head development (GO:0060322)2.49056983
98protein localization to endoplasmic reticulum (GO:0070972)2.48189270
99otic vesicle formation (GO:0030916)2.47364846
100NADH dehydrogenase complex assembly (GO:0010257)2.46876091

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.13016617
2VDR_22108803_ChIP-Seq_LS180_Human3.11372542
3ZNF274_21170338_ChIP-Seq_K562_Hela2.29783515
4GBX2_23144817_ChIP-Seq_PC3_Human2.16741211
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04626218
6CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04456556
7CBX2_27304074_Chip-Seq_ESCs_Mouse2.03993506
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.03419596
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02247338
10BMI1_23680149_ChIP-Seq_NPCS_Mouse2.01151464
11EED_16625203_ChIP-ChIP_MESCs_Mouse1.97304238
12EZH2_27304074_Chip-Seq_ESCs_Mouse1.96553000
13P300_19829295_ChIP-Seq_ESCs_Human1.95509853
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90220005
15EST1_17652178_ChIP-ChIP_JURKAT_Human1.87282846
16CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86435300
17FUS_26573619_Chip-Seq_HEK293_Human1.83078869
18GABP_17652178_ChIP-ChIP_JURKAT_Human1.78798557
19JARID2_20064375_ChIP-Seq_MESCs_Mouse1.77599760
20TAF15_26573619_Chip-Seq_HEK293_Human1.72473535
21MYC_18940864_ChIP-ChIP_HL60_Human1.70520257
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.67537438
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65160595
24TP53_22573176_ChIP-Seq_HFKS_Human1.62885421
25RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60755185
26POU5F1_16153702_ChIP-ChIP_HESCs_Human1.58909450
27BCAT_22108803_ChIP-Seq_LS180_Human1.58737226
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.57766687
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57742506
30MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57024122
31AR_21572438_ChIP-Seq_LNCaP_Human1.55809611
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.53433162
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.51564496
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.50625770
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.50616349
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50616349
37TDRD3_21172665_ChIP-Seq_MCF-7_Human1.47884374
38RNF2_27304074_Chip-Seq_NSC_Mouse1.44700523
39SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42555342
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42132381
41CBP_20019798_ChIP-Seq_JUKART_Human1.42132381
42HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41430512
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40371120
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.37732286
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36322781
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35316319
47RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.33535615
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31055070
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.29964806
50RNF2_18974828_ChIP-Seq_MESCs_Mouse1.28880880
51EZH2_18974828_ChIP-Seq_MESCs_Mouse1.28880880
52NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28557293
53EWS_26573619_Chip-Seq_HEK293_Human1.28249067
54SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28204052
55SOX2_16153702_ChIP-ChIP_HESCs_Human1.26364879
56AR_25329375_ChIP-Seq_VCAP_Human1.26087264
57JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25709985
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24731663
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24707102
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23931429
61RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23375519
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22065735
63AUTS2_25519132_ChIP-Seq_293T-REX_Human1.22007513
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21763700
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21272472
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20969439
67REST_21632747_ChIP-Seq_MESCs_Mouse1.20940662
68NCOR_22424771_ChIP-Seq_293T_Human1.19760884
69P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19360836
70SMAD4_21799915_ChIP-Seq_A2780_Human1.19296940
71RNF2_27304074_Chip-Seq_ESCs_Mouse1.18800068
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18217342
73RUNX2_22187159_ChIP-Seq_PCA_Human1.17664472
74ER_23166858_ChIP-Seq_MCF-7_Human1.16684364
75HTT_18923047_ChIP-ChIP_STHdh_Human1.16012354
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.14554625
77YY1_21170310_ChIP-Seq_MESCs_Mouse1.13289836
78SOX2_19829295_ChIP-Seq_ESCs_Human1.12935859
79NANOG_19829295_ChIP-Seq_ESCs_Human1.12935859
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.12620927
81SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11824372
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.11554439
83ETS1_20019798_ChIP-Seq_JURKAT_Human1.10598836
84CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.09882676
85CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.09017196
86TCF4_22108803_ChIP-Seq_LS180_Human1.08138722
87FOXA1_25329375_ChIP-Seq_VCAP_Human1.08105250
88FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08105250
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.07935081
90STAT3_23295773_ChIP-Seq_U87_Human1.07517546
91IGF1R_20145208_ChIP-Seq_DFB_Human1.03308015
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02241211
93TP53_20018659_ChIP-ChIP_R1E_Mouse0.96707846
94RING1B_27294783_Chip-Seq_ESCs_Mouse0.96554790
95TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96255159
96NANOG_18555785_Chip-Seq_ESCs_Mouse0.95722648
97ELK1_19687146_ChIP-ChIP_HELA_Human0.95166637
98PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94295624
99GATA3_21878914_ChIP-Seq_MCF-7_Human0.94007016
100TCF4_23295773_ChIP-Seq_U87_Human0.93557606

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode6.95198016
2MP0005257_abnormal_intraocular_pressure4.69126013
3MP0002638_abnormal_pupillary_reflex4.31390172
4MP0008789_abnormal_olfactory_epithelium3.67217660
5MP0009379_abnormal_foot_pigmentation3.25346490
6MP0008877_abnormal_DNA_methylation3.23900072
7MP0003787_abnormal_imprinting3.00036982
8MP0005394_taste/olfaction_phenotype2.89614874
9MP0005499_abnormal_olfactory_system2.89614874
10MP0002938_white_spotting2.64003619
11MP0003283_abnormal_digestive_organ2.49842232
12MP0002160_abnormal_reproductive_system2.33561041
13MP0005645_abnormal_hypothalamus_physiol2.06946261
14MP0005360_urolithiasis2.06052428
15MP0004885_abnormal_endolymph1.84990604
16MP0005084_abnormal_gallbladder_morpholo1.78122526
17MP0002653_abnormal_ependyma_morphology1.70225817
18MP0006072_abnormal_retinal_apoptosis1.65822117
19MP0000613_abnormal_salivary_gland1.62956494
20MP0000537_abnormal_urethra_morphology1.62522714
21MP0004133_heterotaxia1.61494972
22MP0000778_abnormal_nervous_system1.61371821
23MP0009745_abnormal_behavioral_response1.51667079
24MP0005551_abnormal_eye_electrophysiolog1.50580593
25MP0000049_abnormal_middle_ear1.44343117
26MP0003121_genomic_imprinting1.42096071
27MP0005389_reproductive_system_phenotype1.38442672
28MP0002735_abnormal_chemical_nociception1.36272863
29MP0005379_endocrine/exocrine_gland_phen1.33815246
30MP0008995_early_reproductive_senescence1.29265954
31MP0008961_abnormal_basal_metabolism1.28409497
32MP0000631_abnormal_neuroendocrine_gland1.28122956
33MP0001485_abnormal_pinna_reflex1.22049852
34MP0002163_abnormal_gland_morphology1.19820782
35MP0005083_abnormal_biliary_tract1.18294277
36MP0005377_hearing/vestibular/ear_phenot1.18189562
37MP0003878_abnormal_ear_physiology1.18189562
38MP0002736_abnormal_nociception_after1.15030077
39MP0005410_abnormal_fertilization1.14669821
40MP0001486_abnormal_startle_reflex1.12199333
41MP0001968_abnormal_touch/_nociception1.11351140
42MP0002837_dystrophic_cardiac_calcinosis1.10932489
43MP0004145_abnormal_muscle_electrophysio1.10883359
44MP0002272_abnormal_nervous_system1.08041829
45MP0000538_abnormal_urinary_bladder1.05937854
46MP0004147_increased_porphyrin_level1.05696622
47MP0003195_calcinosis1.03451196
48MP0004859_abnormal_synaptic_plasticity1.03363696
49MP0000428_abnormal_craniofacial_morphol1.02947582
50MP0001919_abnormal_reproductive_system1.02066514
51MP0009046_muscle_twitch1.00485053
52MP0004142_abnormal_muscle_tone0.99998045
53MP0003938_abnormal_ear_development0.99197674
54MP0002102_abnormal_ear_morphology0.98635245
55MP0003011_delayed_dark_adaptation0.97773508
56MP0002733_abnormal_thermal_nociception0.96783252
57MP0002572_abnormal_emotion/affect_behav0.95765350
58MP0005253_abnormal_eye_physiology0.94760870
59MP0002063_abnormal_learning/memory/cond0.94646705
60MP0002557_abnormal_social/conspecific_i0.94533948
61MP0004215_abnormal_myocardial_fiber0.93367179
62MP0001970_abnormal_pain_threshold0.93211015
63MP0006276_abnormal_autonomic_nervous0.92989863
64MP0002138_abnormal_hepatobiliary_system0.92920804
65MP0002184_abnormal_innervation0.92900735
66MP0002752_abnormal_somatic_nervous0.92874164
67MP0001929_abnormal_gametogenesis0.89821322
68MP0000026_abnormal_inner_ear0.89176018
69MP0003119_abnormal_digestive_system0.88219514
70MP0002064_seizures0.87476323
71MP0000955_abnormal_spinal_cord0.87155712
72MP0003937_abnormal_limbs/digits/tail_de0.83548505
73MP0002210_abnormal_sex_determination0.83047520
74MP0003136_yellow_coat_color0.81586082
75MP0000566_synostosis0.81248455
76MP0003880_abnormal_central_pattern0.80410096
77MP0002282_abnormal_trachea_morphology0.79926509
78MP0010386_abnormal_urinary_bladder0.78771437
79MP0005671_abnormal_response_to0.78766497
80MP0005195_abnormal_posterior_eye0.78118588
81MP0002089_abnormal_postnatal_growth/wei0.77960581
82MP0003890_abnormal_embryonic-extraembry0.77835167
83MP0002734_abnormal_mechanical_nocicepti0.75690340
84MP0003698_abnormal_male_reproductive0.75358983
85MP0002751_abnormal_autonomic_nervous0.74790030
86MP0003635_abnormal_synaptic_transmissio0.73809783
87MP0005646_abnormal_pituitary_gland0.72217290
88MP0000372_irregular_coat_pigmentation0.68566008
89MP0001986_abnormal_taste_sensitivity0.68235732
90MP0004742_abnormal_vestibular_system0.67579831
91MP0005423_abnormal_somatic_nervous0.67353315
92MP0005085_abnormal_gallbladder_physiolo0.65966843
93MP0001119_abnormal_female_reproductive0.65672993
94MP0008872_abnormal_physiological_respon0.65172954
95MP0003959_abnormal_lean_body0.65053330
96MP0002095_abnormal_skin_pigmentation0.64706650
97MP0000383_abnormal_hair_follicle0.64614263
98MP0005391_vision/eye_phenotype0.63734172
99MP0002233_abnormal_nose_morphology0.61744610
100MP0001440_abnormal_grooming_behavior0.61472093

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the fovea (HP:0008060)5.83402151
2Hypoplasia of the fovea (HP:0007750)5.83402151
3Abnormality of the fovea (HP:0000493)5.11508389
4Pendular nystagmus (HP:0012043)4.17242460
5Aplasia/Hypoplasia of the macula (HP:0008059)4.08251287
6Aplasia/Hypoplasia affecting the retina (HP:0008061)3.81227350
7Optic nerve hypoplasia (HP:0000609)3.56220958
8Pancreatic fibrosis (HP:0100732)3.45740993
9Optic nerve coloboma (HP:0000588)3.45666307
10Absent rod-and cone-mediated responses on ERG (HP:0007688)3.40809930
11True hermaphroditism (HP:0010459)3.30609854
12Pancreatic cysts (HP:0001737)3.22708100
13Aplasia/Hypoplasia of the optic nerve (HP:0008058)3.15269216
14Reticulocytopenia (HP:0001896)3.08811178
15Congenital stationary night blindness (HP:0007642)2.97543170
16Abnormal number of erythroid precursors (HP:0012131)2.92984389
173-Methylglutaconic aciduria (HP:0003535)2.89715870
18Large eyes (HP:0001090)2.79265880
19Abnormality of cells of the erythroid lineage (HP:0012130)2.71939976
20Generalized aminoaciduria (HP:0002909)2.63689154
21Abnormal rod and cone electroretinograms (HP:0008323)2.63376062
22Congenital, generalized hypertrichosis (HP:0004540)2.62287196
23Hip contracture (HP:0003273)2.61339167
24Nephronophthisis (HP:0000090)2.58617276
25Oligodactyly (hands) (HP:0001180)2.58369242
26Molar tooth sign on MRI (HP:0002419)2.46985993
27Abnormality of midbrain morphology (HP:0002418)2.46985993
28Keratoconus (HP:0000563)2.45428419
29Increased corneal curvature (HP:0100692)2.45428419
30Limb dystonia (HP:0002451)2.43593072
31Septo-optic dysplasia (HP:0100842)2.41633358
32Decreased central vision (HP:0007663)2.39102196
33Proximal tubulopathy (HP:0000114)2.37387851
34Abnormality of the labia minora (HP:0012880)2.35190818
35Acute necrotizing encephalopathy (HP:0006965)2.32417187
36Lissencephaly (HP:0001339)2.26677173
37Thyroid-stimulating hormone excess (HP:0002925)2.24276521
38Ectopic kidney (HP:0000086)2.22337747
39Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.21469664
40Myokymia (HP:0002411)2.21181710
41Sclerocornea (HP:0000647)2.20325418
42Multiple enchondromatosis (HP:0005701)2.17610633
43Reduced antithrombin III activity (HP:0001976)2.13390199
44Abolished electroretinogram (ERG) (HP:0000550)2.11857187
45Methylmalonic acidemia (HP:0002912)2.10259227
46Attenuation of retinal blood vessels (HP:0007843)2.10242923
47Aplasia/Hypoplasia of the tibia (HP:0005772)2.08616384
48Methylmalonic aciduria (HP:0012120)2.07207768
49Renal cortical cysts (HP:0000803)2.06123280
50Type II lissencephaly (HP:0007260)2.06118932
51Male pseudohermaphroditism (HP:0000037)2.05362833
52Aplasia/Hypoplasia of the lens (HP:0008063)2.03598497
53Progressive macrocephaly (HP:0004481)2.03048050
54Difficulty running (HP:0009046)2.01903297
55Abnormality of DNA repair (HP:0003254)2.00655600
56Short tibia (HP:0005736)1.99264496
57Anencephaly (HP:0002323)1.97437745
58Abnormality of the renal medulla (HP:0100957)1.95144486
59Mitochondrial inheritance (HP:0001427)1.93465976
60Aplasia/Hypoplasia of the hallux (HP:0008362)1.91082929
61Anophthalmia (HP:0000528)1.91048345
62Short hallux (HP:0010109)1.90957164
63Macrocytic anemia (HP:0001972)1.89459422
64Increased hepatocellular lipid droplets (HP:0006565)1.88965369
65Pachygyria (HP:0001302)1.88564859
66Hip dysplasia (HP:0001385)1.87245263
67Abnormal mitochondria in muscle tissue (HP:0008316)1.86428744
68Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.85934283
69Cystic liver disease (HP:0006706)1.83298572
70Increased CSF lactate (HP:0002490)1.82674610
71Chronic hepatic failure (HP:0100626)1.82541187
72Aplasia/Hypoplasia of the tongue (HP:0010295)1.82114783
73Abnormality of the renal collecting system (HP:0004742)1.81305737
74Retinal dysplasia (HP:0007973)1.81305398
75Abnormality of the aortic arch (HP:0012303)1.80801924
76Congenital glaucoma (HP:0001087)1.79017400
77Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.76697822
78Abnormality of alanine metabolism (HP:0010916)1.76697822
79Hyperalaninemia (HP:0003348)1.76697822
80Optic disc pallor (HP:0000543)1.75362549
81Keratitis (HP:0000491)1.75220572
82Stenosis of the external auditory canal (HP:0000402)1.72275586
83Aplasia/Hypoplasia of the patella (HP:0006498)1.71869402
84Congenital hepatic fibrosis (HP:0002612)1.71866392
85Acute encephalopathy (HP:0006846)1.71846856
86Homocystinuria (HP:0002156)1.71597819
87Abnormality of homocysteine metabolism (HP:0010919)1.71597819
88Hypoplasia of the uterus (HP:0000013)1.71503849
89Glycosuria (HP:0003076)1.69375674
90Abnormality of urine glucose concentration (HP:0011016)1.69375674
91Absent thumb (HP:0009777)1.69136664
92Renal Fanconi syndrome (HP:0001994)1.69104146
93Abnormality of the renal cortex (HP:0011035)1.68343893
94Cerebral edema (HP:0002181)1.65612257
95Concave nail (HP:0001598)1.65237677
96Furrowed tongue (HP:0000221)1.64955619
97Aplasia/Hypoplasia of the brainstem (HP:0007362)1.64740654
98Hypoplasia of the brainstem (HP:0002365)1.64740654
99Oligodactyly (HP:0012165)1.64669346
100Lipid accumulation in hepatocytes (HP:0006561)1.64202605

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK23.82769381
2MAPK133.75910978
3EPHB23.70219357
4PNCK3.48931572
5ZAK3.10626978
6STK163.02092061
7WEE12.76685101
8CDK192.70463457
9FRK2.26972548
10MARK12.23450087
11PINK12.10792405
12PTK2B1.98271777
13TAOK31.96413714
14GRK71.89214870
15WNK41.85955832
16BCKDK1.75692262
17VRK21.74441070
18OXSR11.72056055
19INSRR1.67882767
20GRK11.62776747
21TSSK61.58251940
22DYRK21.53961459
23TAOK11.50646379
24TXK1.43917524
25BMPR1B1.32378145
26TLK11.28894809
27STK391.24269808
28PRKCG1.21262254
29CDK31.17395880
30WNK31.10802152
31PKN11.09304661
32NTRK21.04357493
33PHKG21.02775751
34PHKG11.02775751
35HIPK21.00664783
36MAPK151.00292231
37NTRK31.00159352
38KIT0.92834347
39ADRBK10.92500128
40TYRO30.90830061
41VRK10.89784198
42DYRK30.87079911
43CDC70.82615181
44RPS6KB10.81659213
45ERBB20.80403152
46TRIM280.78453920
47MST40.77591297
48STK38L0.76990668
49MUSK0.75919873
50TIE10.74797340
51CHEK20.74449960
52EPHA40.74023823
53RPS6KA20.72168439
54SGK20.70600676
55AURKA0.69435114
56PIK3CA0.69373984
57IRAK20.64688049
58PAK30.63884873
59SRPK10.61245282
60NEK90.60551048
61MAP4K20.59887773
62KSR10.58150310
63PLK30.57697774
64RPS6KA60.55170588
65PRKACA0.54831747
66CSNK1A10.53969715
67OBSCN0.50757433
68ITK0.49711320
69MKNK10.48908150
70SGK4940.48897605
71SGK2230.48897605
72RPS6KB20.47416881
73MAP3K40.41433097
74ATR0.41411539
75CAMK10.41233011
76RPS6KC10.40416810
77RPS6KL10.40416810
78STK110.39794895
79CSNK2A20.39162313
80KDR0.39104906
81MARK20.39077703
82MINK10.38890951
83CSNK2A10.36560863
84RPS6KA50.35897689
85RPS6KA10.35803150
86IKBKE0.35612382
87PRKCZ0.34956649
88PRKACB0.34023217
89CSNK1E0.33773102
90TTK0.32974104
91PLK10.32541994
92PLK40.32378935
93SGK10.31671560
94NUAK10.31243722
95PRKG10.30855367
96PIK3CG0.30420601
97MAP2K70.29652845
98PRKCA0.29633436
99MAP2K60.29254889
100MAPK70.28573979

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.68141449
2Ribosome_Homo sapiens_hsa030103.49341537
3Oxidative phosphorylation_Homo sapiens_hsa001903.17579716
4Parkinsons disease_Homo sapiens_hsa050122.79869642
5Nicotine addiction_Homo sapiens_hsa050332.24845757
6Sulfur relay system_Homo sapiens_hsa041222.18693832
7Phototransduction_Homo sapiens_hsa047442.17446393
8Cardiac muscle contraction_Homo sapiens_hsa042602.09639468
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.09370271
10Sulfur metabolism_Homo sapiens_hsa009202.09111509
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.01744418
12Alzheimers disease_Homo sapiens_hsa050101.87637544
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.85275370
14Linoleic acid metabolism_Homo sapiens_hsa005911.84685211
15Huntingtons disease_Homo sapiens_hsa050161.84325846
16RNA polymerase_Homo sapiens_hsa030201.76924830
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.67373947
18Butanoate metabolism_Homo sapiens_hsa006501.64668441
19Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.63052717
20Protein export_Homo sapiens_hsa030601.62982251
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.60517232
22Retinol metabolism_Homo sapiens_hsa008301.53496629
23Selenocompound metabolism_Homo sapiens_hsa004501.52439457
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.51878463
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.50791239
26Caffeine metabolism_Homo sapiens_hsa002321.49263413
27Olfactory transduction_Homo sapiens_hsa047401.49018622
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29536579
29Homologous recombination_Homo sapiens_hsa034401.27960364
30Tryptophan metabolism_Homo sapiens_hsa003801.24894612
31Basal cell carcinoma_Homo sapiens_hsa052171.23213858
32Pyrimidine metabolism_Homo sapiens_hsa002401.18312817
33Hedgehog signaling pathway_Homo sapiens_hsa043401.18301668
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17812106
35Chemical carcinogenesis_Homo sapiens_hsa052041.10589221
36Fanconi anemia pathway_Homo sapiens_hsa034601.09793488
37Ovarian steroidogenesis_Homo sapiens_hsa049131.08366858
38Purine metabolism_Homo sapiens_hsa002301.07945110
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07941532
40Morphine addiction_Homo sapiens_hsa050321.06011771
41Insulin secretion_Homo sapiens_hsa049111.05370713
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05296730
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04401581
44Basal transcription factors_Homo sapiens_hsa030221.02282969
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01144402
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.98574231
47RNA degradation_Homo sapiens_hsa030180.97908521
48Taste transduction_Homo sapiens_hsa047420.96627427
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95463424
50Proteasome_Homo sapiens_hsa030500.94845817
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91944578
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91289020
53Circadian entrainment_Homo sapiens_hsa047130.90174013
54RNA transport_Homo sapiens_hsa030130.87569848
55Regulation of autophagy_Homo sapiens_hsa041400.85951187
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85227618
57Primary immunodeficiency_Homo sapiens_hsa053400.83453574
58Peroxisome_Homo sapiens_hsa041460.79584669
59Ether lipid metabolism_Homo sapiens_hsa005650.79323697
60GABAergic synapse_Homo sapiens_hsa047270.76999045
61Salivary secretion_Homo sapiens_hsa049700.76099553
62Propanoate metabolism_Homo sapiens_hsa006400.75417316
63Axon guidance_Homo sapiens_hsa043600.72560595
64Calcium signaling pathway_Homo sapiens_hsa040200.70820011
65Cocaine addiction_Homo sapiens_hsa050300.69992114
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69959992
67Folate biosynthesis_Homo sapiens_hsa007900.69655048
68Nitrogen metabolism_Homo sapiens_hsa009100.68605087
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65927560
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64084311
71Bile secretion_Homo sapiens_hsa049760.63786937
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.62255975
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61458608
74Amphetamine addiction_Homo sapiens_hsa050310.59931590
75One carbon pool by folate_Homo sapiens_hsa006700.59881616
76Serotonergic synapse_Homo sapiens_hsa047260.59612295
77ABC transporters_Homo sapiens_hsa020100.58030285
78beta-Alanine metabolism_Homo sapiens_hsa004100.57071064
79Base excision repair_Homo sapiens_hsa034100.55189542
80Spliceosome_Homo sapiens_hsa030400.53925996
81Arachidonic acid metabolism_Homo sapiens_hsa005900.53642890
82Metabolic pathways_Homo sapiens_hsa011000.53332774
83Wnt signaling pathway_Homo sapiens_hsa043100.52027799
84Glutamatergic synapse_Homo sapiens_hsa047240.49237037
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.49081601
86Steroid biosynthesis_Homo sapiens_hsa001000.48494644
87Type I diabetes mellitus_Homo sapiens_hsa049400.47203218
88Fat digestion and absorption_Homo sapiens_hsa049750.44090879
89Vitamin digestion and absorption_Homo sapiens_hsa049770.43855252
90Systemic lupus erythematosus_Homo sapiens_hsa053220.43547346
91Nucleotide excision repair_Homo sapiens_hsa034200.43377726
92Arginine and proline metabolism_Homo sapiens_hsa003300.42856485
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40074558
94Gastric acid secretion_Homo sapiens_hsa049710.39827602
95cAMP signaling pathway_Homo sapiens_hsa040240.39742741
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.39221679
97p53 signaling pathway_Homo sapiens_hsa041150.38360122
98Cholinergic synapse_Homo sapiens_hsa047250.37587925
99Alcoholism_Homo sapiens_hsa050340.37529026
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37253650

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