BRD7P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gamma-aminobutyric acid transport (GO:0015812)4.54721649
2somite rostral/caudal axis specification (GO:0032525)4.39751733
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.28356986
4indolalkylamine catabolic process (GO:0046218)4.04560288
5tryptophan catabolic process (GO:0006569)4.04560288
6indole-containing compound catabolic process (GO:0042436)4.04560288
7forebrain neuron differentiation (GO:0021879)3.83752023
8behavioral response to nicotine (GO:0035095)3.72800372
9intraciliary transport (GO:0042073)3.70697130
10acrosome assembly (GO:0001675)3.70609684
11behavioral response to ethanol (GO:0048149)3.63755457
12resolution of meiotic recombination intermediates (GO:0000712)3.63026141
13positive regulation of gastrulation (GO:2000543)3.57947932
14interkinetic nuclear migration (GO:0022027)3.55016651
15spinal cord association neuron differentiation (GO:0021527)3.54281126
16cilium morphogenesis (GO:0060271)3.50987782
17indolalkylamine metabolic process (GO:0006586)3.46741702
18establishment of protein localization to mitochondrial membrane (GO:0090151)3.45368673
19L-fucose metabolic process (GO:0042354)3.44680910
20L-fucose catabolic process (GO:0042355)3.44680910
21fucose catabolic process (GO:0019317)3.44680910
22respiratory chain complex IV assembly (GO:0008535)3.38169168
23positive regulation of oligodendrocyte differentiation (GO:0048714)3.38153595
24neural tube formation (GO:0001841)3.36314610
25cilium organization (GO:0044782)3.34747258
26nonmotile primary cilium assembly (GO:0035058)3.34404186
27cilium assembly (GO:0042384)3.33139539
28protein complex biogenesis (GO:0070271)3.30852156
29tryptophan metabolic process (GO:0006568)3.27147808
30epithelial cilium movement (GO:0003351)3.25903026
31negative regulation of synaptic transmission, GABAergic (GO:0032229)3.24680118
32neuronal stem cell maintenance (GO:0097150)3.22497012
33protein localization to cilium (GO:0061512)3.18854662
34photoreceptor cell development (GO:0042461)3.18773637
35kynurenine metabolic process (GO:0070189)3.16334486
36mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.14533085
37left/right axis specification (GO:0070986)3.11607554
38cilium movement (GO:0003341)3.11305280
39mitochondrial respiratory chain complex I assembly (GO:0032981)3.09499250
40NADH dehydrogenase complex assembly (GO:0010257)3.09499250
41mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.09499250
42nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.08749912
43pyrimidine nucleobase catabolic process (GO:0006208)3.08532312
44retinal cone cell development (GO:0046549)3.07466603
45cell proliferation in forebrain (GO:0021846)3.05263625
46exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.97572744
47signal peptide processing (GO:0006465)2.97046349
48cilium or flagellum-dependent cell motility (GO:0001539)2.96500328
49primitive streak formation (GO:0090009)2.89426077
50negative regulation of oligodendrocyte differentiation (GO:0048715)2.86901641
51indole-containing compound metabolic process (GO:0042430)2.86028364
52mitochondrial respiratory chain complex assembly (GO:0033108)2.84372602
53detection of light stimulus involved in visual perception (GO:0050908)2.82150366
54detection of light stimulus involved in sensory perception (GO:0050962)2.82150366
55auditory behavior (GO:0031223)2.81466698
56regulation of development, heterochronic (GO:0040034)2.80298227
57centriole replication (GO:0007099)2.77604888
58cellular ketone body metabolic process (GO:0046950)2.76473790
59preassembly of GPI anchor in ER membrane (GO:0016254)2.75355350
60base-excision repair, AP site formation (GO:0006285)2.74301411
61regulation of oligodendrocyte differentiation (GO:0048713)2.74295995
62L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.73347131
63thalamus development (GO:0021794)2.72805372
64cytochrome complex assembly (GO:0017004)2.72449651
65C4-dicarboxylate transport (GO:0015740)2.72392946
66smoothened signaling pathway (GO:0007224)2.70822310
67response to pheromone (GO:0019236)2.69783027
68amine catabolic process (GO:0009310)2.69383457
69cellular biogenic amine catabolic process (GO:0042402)2.69383457
70eye photoreceptor cell development (GO:0042462)2.65883910
71neuron fate determination (GO:0048664)2.65309929
72peptidyl-histidine modification (GO:0018202)2.64422406
73positive regulation of Notch signaling pathway (GO:0045747)2.64193692
74mechanosensory behavior (GO:0007638)2.63208855
75DNA damage response, detection of DNA damage (GO:0042769)2.62772311
76regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.62156852
77snRNA transcription (GO:0009301)2.61329711
78negative regulation of axon guidance (GO:1902668)2.60845656
79negative regulation of mast cell activation (GO:0033004)2.60002012
80nucleotide transmembrane transport (GO:1901679)2.59154174
81olfactory bulb development (GO:0021772)2.58589721
82regulation of cilium movement (GO:0003352)2.56869387
83mannosylation (GO:0097502)2.55935191
84nephron tubule morphogenesis (GO:0072078)2.55454367
85nephron epithelium morphogenesis (GO:0072088)2.55454367
86regulation of non-canonical Wnt signaling pathway (GO:2000050)2.55123463
87positive regulation of RNA splicing (GO:0033120)2.52885249
88negative regulation of cytosolic calcium ion concentration (GO:0051481)2.52741503
89auditory receptor cell differentiation (GO:0042491)2.52420190
90cellular component assembly involved in morphogenesis (GO:0010927)2.51611732
91melanosome transport (GO:0032402)2.50650273
92somite development (GO:0061053)2.50537598
93GPI anchor metabolic process (GO:0006505)2.50346389
94cell differentiation in spinal cord (GO:0021515)2.50169053
95nucleobase catabolic process (GO:0046113)2.49768921
96melanosome localization (GO:0032400)2.49286665
97rRNA catabolic process (GO:0016075)2.49222451
98central nervous system projection neuron axonogenesis (GO:0021952)2.48412641
99regulation of timing of cell differentiation (GO:0048505)2.48410279
100microtubule polymerization or depolymerization (GO:0031109)2.47371792

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human4.14454045
2ZNF274_21170338_ChIP-Seq_K562_Hela3.71635780
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.13937810
4TAF15_26573619_Chip-Seq_HEK293_Human3.04645665
5GBX2_23144817_ChIP-Seq_PC3_Human2.83404812
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.82315492
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.61637187
8FUS_26573619_Chip-Seq_HEK293_Human2.56123826
9EWS_26573619_Chip-Seq_HEK293_Human2.55834550
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.45448189
11VDR_22108803_ChIP-Seq_LS180_Human2.44077845
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.41495216
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22641257
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.20914580
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17324938
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.15533653
17GABP_17652178_ChIP-ChIP_JURKAT_Human1.95331747
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92414007
19P300_19829295_ChIP-Seq_ESCs_Human1.89287567
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.78313358
21ELK1_19687146_ChIP-ChIP_HELA_Human1.69911906
22MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.69554645
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68277409
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.67257896
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66058477
26IRF1_19129219_ChIP-ChIP_H3396_Human1.65452793
27MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.65324781
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.64533693
29CBP_20019798_ChIP-Seq_JUKART_Human1.64533693
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64275341
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.59322987
32TP53_22573176_ChIP-Seq_HFKS_Human1.56816899
33ER_23166858_ChIP-Seq_MCF-7_Human1.56557188
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52273728
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.52257584
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51037460
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.45945763
38SMAD4_21799915_ChIP-Seq_A2780_Human1.40997674
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.40983994
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40792393
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40099190
42STAT3_23295773_ChIP-Seq_U87_Human1.38138040
43RNF2_27304074_Chip-Seq_NSC_Mouse1.38135414
44KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.37529654
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35412111
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35412111
47MYC_18940864_ChIP-ChIP_HL60_Human1.32228771
48VDR_23849224_ChIP-Seq_CD4+_Human1.30625999
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.29401399
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29040395
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28623053
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28433090
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.27829809
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26453378
55AR_21572438_ChIP-Seq_LNCaP_Human1.26004449
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24547023
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22694459
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.22507985
59RUNX2_22187159_ChIP-Seq_PCA_Human1.22274706
60AR_25329375_ChIP-Seq_VCAP_Human1.18341812
61TCF4_23295773_ChIP-Seq_U87_Human1.18220022
62KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18082854
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16519477
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15780600
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15474109
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15171598
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15161103
68BCAT_22108803_ChIP-Seq_LS180_Human1.14871145
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13837792
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13494655
71RXR_22108803_ChIP-Seq_LS180_Human1.13104645
72ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11579714
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.10955936
74REST_21632747_ChIP-Seq_MESCs_Mouse1.08200395
75EZH2_27304074_Chip-Seq_ESCs_Mouse1.06640340
76FLI1_21867929_ChIP-Seq_TH2_Mouse1.06427697
77P53_22387025_ChIP-Seq_ESCs_Mouse1.05524435
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.05256779
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.04839219
80LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04752507
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04403008
82FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04347131
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02961149
84TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02695945
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00832309
86TCF4_22108803_ChIP-Seq_LS180_Human1.00651009
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00273294
88CRX_20693478_ChIP-Seq_RETINA_Mouse0.97683208
89PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96870108
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96827691
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96798732
92NCOR_22424771_ChIP-Seq_293T_Human0.96592471
93P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95741894
94P300_18555785_Chip-Seq_ESCs_Mouse0.95183730
95ETS1_20019798_ChIP-Seq_JURKAT_Human0.95094499
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94939919
97JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.94231154
98STAT3_18555785_Chip-Seq_ESCs_Mouse0.93847974
99NANOG_19829295_ChIP-Seq_ESCs_Human0.92932618
100SOX2_19829295_ChIP-Seq_ESCs_Human0.92932618

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.58217191
2MP0006292_abnormal_olfactory_placode3.93117785
3MP0008057_abnormal_DNA_replication3.20978808
4MP0003880_abnormal_central_pattern3.13851371
5MP0002234_abnormal_pharynx_morphology2.31986322
6MP0008961_abnormal_basal_metabolism2.24309220
7MP0003890_abnormal_embryonic-extraembry2.23590292
8MP0000778_abnormal_nervous_system2.20074655
9MP0000566_synostosis2.09702109
10MP0002938_white_spotting2.07391392
11MP0004142_abnormal_muscle_tone2.00704993
12MP0001986_abnormal_taste_sensitivity2.00308223
13MP0008789_abnormal_olfactory_epithelium1.98392595
14MP0002638_abnormal_pupillary_reflex1.97557356
15MP0005394_taste/olfaction_phenotype1.97068479
16MP0005499_abnormal_olfactory_system1.97068479
17MP0002928_abnormal_bile_duct1.95685544
18MP0005360_urolithiasis1.94664994
19MP0005551_abnormal_eye_electrophysiolog1.92022948
20MP0004133_heterotaxia1.89039040
21MP0003136_yellow_coat_color1.88267045
22MP0004145_abnormal_muscle_electrophysio1.83579615
23MP0005084_abnormal_gallbladder_morpholo1.82247919
24MP0006072_abnormal_retinal_apoptosis1.80309840
25MP0002736_abnormal_nociception_after1.78047443
26MP0002822_catalepsy1.72127360
27MP0005174_abnormal_tail_pigmentation1.67010680
28MP0000427_abnormal_hair_cycle1.66700202
29MP0002653_abnormal_ependyma_morphology1.52936438
30MP0001968_abnormal_touch/_nociception1.51552624
31MP0009046_muscle_twitch1.50898136
32MP0001984_abnormal_olfaction1.50004366
33MP0005253_abnormal_eye_physiology1.47441533
34MP0004043_abnormal_pH_regulation1.40211784
35MP0006276_abnormal_autonomic_nervous1.39813540
36MP0002102_abnormal_ear_morphology1.36173515
37MP0003787_abnormal_imprinting1.34477685
38MP0000631_abnormal_neuroendocrine_gland1.34468046
39MP0002095_abnormal_skin_pigmentation1.33898404
40MP0009745_abnormal_behavioral_response1.30639727
41MP0001293_anophthalmia1.27754829
42MP0003195_calcinosis1.27293260
43MP0005266_abnormal_metabolism1.25813950
44MP0001529_abnormal_vocalization1.25237641
45MP0003121_genomic_imprinting1.25195291
46MP0002067_abnormal_sensory_capabilities1.24510222
47MP0000516_abnormal_urinary_system1.21524481
48MP0005367_renal/urinary_system_phenotyp1.21524481
49MP0005187_abnormal_penis_morphology1.20327431
50MP0002272_abnormal_nervous_system1.17453246
51MP0002751_abnormal_autonomic_nervous1.16974146
52MP0002572_abnormal_emotion/affect_behav1.16774751
53MP0002064_seizures1.15324762
54MP0002752_abnormal_somatic_nervous1.15072878
55MP0003252_abnormal_bile_duct1.14710421
56MP0008058_abnormal_DNA_repair1.13790691
57MP0005195_abnormal_posterior_eye1.12686166
58MP0002557_abnormal_social/conspecific_i1.11972193
59MP0002735_abnormal_chemical_nociception1.09258306
60MP0005646_abnormal_pituitary_gland1.09027680
61MP0001286_abnormal_eye_development1.08817028
62MP0003011_delayed_dark_adaptation1.08615521
63MP0003635_abnormal_synaptic_transmissio1.06156675
64MP0000372_irregular_coat_pigmentation1.04099545
65MP0005391_vision/eye_phenotype1.03194742
66MP0003567_abnormal_fetal_cardiomyocyte1.01550373
67MP0004885_abnormal_endolymph1.00365962
68MP0002734_abnormal_mechanical_nocicepti0.99772933
69MP0002063_abnormal_learning/memory/cond0.98902730
70MP0003937_abnormal_limbs/digits/tail_de0.98895703
71MP0000026_abnormal_inner_ear0.97400706
72MP0003122_maternal_imprinting0.96207343
73MP0002882_abnormal_neuron_morphology0.95890255
74MP0010030_abnormal_orbit_morphology0.95354894
75MP0000955_abnormal_spinal_cord0.93960155
76MP0001502_abnormal_circadian_rhythm0.93539698
77MP0003646_muscle_fatigue0.91267897
78MP0003119_abnormal_digestive_system0.90774207
79MP0001324_abnormal_eye_pigmentation0.90629915
80MP0001485_abnormal_pinna_reflex0.89160974
81MP0009379_abnormal_foot_pigmentation0.88867602
82MP0000538_abnormal_urinary_bladder0.88250082
83MP0000049_abnormal_middle_ear0.88008638
84MP0002152_abnormal_brain_morphology0.87247826
85MP0002837_dystrophic_cardiac_calcinosis0.86236019
86MP0002184_abnormal_innervation0.85057264
87MP0001905_abnormal_dopamine_level0.83938223
88MP0002069_abnormal_eating/drinking_beha0.82196857
89MP0003938_abnormal_ear_development0.82016768
90MP0002233_abnormal_nose_morphology0.82008592
91MP0003861_abnormal_nervous_system0.80932200
92MP0001486_abnormal_startle_reflex0.80544845
93MP0001346_abnormal_lacrimal_gland0.80310444
94MP0002090_abnormal_vision0.79991155
95MP0001299_abnormal_eye_distance/0.79002847
96MP0000647_abnormal_sebaceous_gland0.77897422
97MP0008872_abnormal_physiological_respon0.76667359
98MP0008995_early_reproductive_senescence0.75375035
99MP0010386_abnormal_urinary_bladder0.74190911
100MP0003315_abnormal_perineum_morphology0.72728684

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic fibrosis (HP:0100732)4.62285132
2Molar tooth sign on MRI (HP:0002419)4.16756846
3Abnormality of midbrain morphology (HP:0002418)4.16756846
4Chronic hepatic failure (HP:0100626)4.00800957
5Congenital stationary night blindness (HP:0007642)3.80431295
6Pancreatic cysts (HP:0001737)3.70412477
7True hermaphroditism (HP:0010459)3.67554709
8Medial flaring of the eyebrow (HP:0010747)3.58572335
9Nephronophthisis (HP:0000090)3.54387088
10Aplasia/Hypoplasia of the tibia (HP:0005772)3.31586650
11Genetic anticipation (HP:0003743)3.21173878
12Nephrogenic diabetes insipidus (HP:0009806)3.07323898
13Gait imbalance (HP:0002141)3.06490358
14Congenital primary aphakia (HP:0007707)3.05251389
15Abnormality of the renal medulla (HP:0100957)3.00619164
16Aplasia/Hypoplasia of the tongue (HP:0010295)2.97694333
17Progressive cerebellar ataxia (HP:0002073)2.88509928
18Hepatocellular necrosis (HP:0001404)2.83169825
19Hepatic necrosis (HP:0002605)2.75696813
20Genital tract atresia (HP:0001827)2.74150647
21Congenital hepatic fibrosis (HP:0002612)2.63593961
22Septo-optic dysplasia (HP:0100842)2.59880142
23Cystic liver disease (HP:0006706)2.57450601
24Aplasia/Hypoplasia of the uvula (HP:0010293)2.55019767
25Poor coordination (HP:0002370)2.49177463
26Mitochondrial inheritance (HP:0001427)2.47472721
27Increased CSF lactate (HP:0002490)2.47394461
28Vaginal atresia (HP:0000148)2.44800599
29Short tibia (HP:0005736)2.44463948
30Abnormal mitochondria in muscle tissue (HP:0008316)2.34037799
31Acute necrotizing encephalopathy (HP:0006965)2.30902787
323-Methylglutaconic aciduria (HP:0003535)2.26952125
33Tubular atrophy (HP:0000092)2.24213750
34Colon cancer (HP:0003003)2.22318797
35Preaxial hand polydactyly (HP:0001177)2.21248487
36Progressive inability to walk (HP:0002505)2.20398364
37Postaxial foot polydactyly (HP:0001830)2.20333834
38Hyperventilation (HP:0002883)2.19760959
39Abnormality of the labia minora (HP:0012880)2.19430352
40Large for gestational age (HP:0001520)2.17915949
41Postaxial hand polydactyly (HP:0001162)2.17658458
42Patellar aplasia (HP:0006443)2.16287218
43Clumsiness (HP:0002312)2.12752991
44Abnormality of the renal cortex (HP:0011035)2.12728695
45Anencephaly (HP:0002323)2.11656247
46Abnormal respiratory epithelium morphology (HP:0012253)2.09160313
47Abnormal respiratory motile cilium morphology (HP:0005938)2.09160313
48Humeroradial synostosis (HP:0003041)2.08504078
49Synostosis involving the elbow (HP:0003938)2.08504078
50Renal cortical cysts (HP:0000803)2.08426288
51Sclerocornea (HP:0000647)2.07793178
52Hypoplasia of the pons (HP:0012110)2.06144319
53Oligodactyly (hands) (HP:0001180)2.01583437
54Gastrointestinal atresia (HP:0002589)2.00172510
55Abnormality of the pons (HP:0007361)1.99634550
56Tubulointerstitial nephritis (HP:0001970)1.98907203
57Tubulointerstitial abnormality (HP:0001969)1.97048648
58Epileptic encephalopathy (HP:0200134)1.96803560
59Acute encephalopathy (HP:0006846)1.96535980
60Aplasia/Hypoplasia of the patella (HP:0006498)1.96291988
61Dynein arm defect of respiratory motile cilia (HP:0012255)1.95195242
62Absent/shortened dynein arms (HP:0200106)1.95195242
63Hypsarrhythmia (HP:0002521)1.95134322
64Birth length less than 3rd percentile (HP:0003561)1.93342721
65Preaxial foot polydactyly (HP:0001841)1.92683442
66Meckel diverticulum (HP:0002245)1.92311394
67Broad foot (HP:0001769)1.92126456
68Drooling (HP:0002307)1.91969727
69Abnormal ciliary motility (HP:0012262)1.91456374
70Occipital encephalocele (HP:0002085)1.91383190
71Median cleft lip (HP:0000161)1.91095305
72Narrow forehead (HP:0000341)1.90866509
73Lipid accumulation in hepatocytes (HP:0006561)1.90626576
74Short foot (HP:0001773)1.90253467
75Protruding tongue (HP:0010808)1.87815606
76Gaze-evoked nystagmus (HP:0000640)1.87571565
77Bile duct proliferation (HP:0001408)1.87162496
78Abnormal biliary tract physiology (HP:0012439)1.87162496
79Lissencephaly (HP:0001339)1.85922961
80Supernumerary spleens (HP:0009799)1.85109001
81Progressive macrocephaly (HP:0004481)1.83445161
82Abnormal number of erythroid precursors (HP:0012131)1.83279265
83Pachygyria (HP:0001302)1.81150487
84Abnormality of the ileum (HP:0001549)1.80711809
85Epileptiform EEG discharges (HP:0011182)1.80630197
86Rib fusion (HP:0000902)1.80187679
87EEG with generalized epileptiform discharges (HP:0011198)1.80109989
88Absent forearm bone (HP:0003953)1.78712060
89Aplasia involving forearm bones (HP:0009822)1.78712060
90Inability to walk (HP:0002540)1.77562460
91Broad-based gait (HP:0002136)1.76697256
92Oculomotor apraxia (HP:0000657)1.75710817
93Abnormal protein glycosylation (HP:0012346)1.75465752
94Abnormal glycosylation (HP:0012345)1.75465752
95Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.75465752
96Abnormal protein N-linked glycosylation (HP:0012347)1.75465752
97Hypoalbuminemia (HP:0003073)1.73375974
98Abnormal albumin level (HP:0012116)1.73375974
99Pendular nystagmus (HP:0012043)1.71700562
100Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.71689252

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B3.59298860
2FRK3.50380140
3EPHA43.42186337
4TRIM283.36322773
5WNK32.69757532
6MAP4K22.57734572
7ACVR1B2.37643950
8BCKDK2.33994515
9MAP3K42.32617986
10MKNK22.27596988
11BCR2.27038524
12DYRK32.13097190
13PNCK1.98684934
14ADRBK21.92935525
15NUAK11.85062855
16BRSK21.83461627
17MARK11.82853999
18CAMKK21.81945110
19MAP2K71.78425602
20CASK1.74143085
21AKT31.68811244
22PIK3CA1.68543003
23MKNK11.63190808
24MAP2K41.54387151
25STK38L1.46454186
26CSNK1G11.41019403
27EPHA31.38371978
28NME11.32142773
29WEE11.31277620
30TGFBR11.30687697
31CSNK1A1L1.28544323
32BRD41.27496646
33NTRK21.26000651
34EPHB21.21603449
35CSNK1G21.17364484
36CSNK1G31.15502352
37TAOK31.07982585
38MAPK131.07556904
39FGFR21.05441430
40MAP3K61.03797223
41RPS6KA41.02504497
42PKN10.99165236
43ADRBK10.98525767
44INSRR0.96846936
45GRK10.96616413
46DAPK20.95347974
47MAPK150.94063059
48DYRK1A0.92507010
49ZAK0.90446354
50PAK30.89830594
51TNIK0.89540653
52CHUK0.86914212
53DYRK20.86099297
54ERBB20.81679494
55TSSK60.78975413
56PRKCG0.78099629
57CAMK40.74014994
58PIK3CG0.69236836
59PINK10.65725251
60ATR0.62687051
61NTRK30.59627969
62CDK80.54512406
63CDK30.53803166
64PLK40.53094149
65PRKG10.52871687
66OBSCN0.52111382
67BRSK10.51538612
68NLK0.50266525
69RPS6KA50.49910545
70NEK20.48128739
71TXK0.48069274
72FLT30.47492226
73PTK2B0.45878559
74MAP3K50.45773928
75VRK10.42863496
76MUSK0.42844277
77SGK20.41390375
78MINK10.40539825
79CAMK1D0.40255013
80PRKACB0.38973657
81CAMK1G0.38139662
82PRKCE0.38004360
83TYRO30.37717353
84TNK20.37704647
85PRKACA0.37080745
86DYRK1B0.36573691
87NEK10.35640771
88CSNK1A10.33993070
89CAMK2A0.33741774
90FGFR10.32906451
91MAP3K70.32011513
92SGK2230.30941599
93SGK4940.30941599
94CSNK1E0.29401169
95PLK10.29313562
96CAMK10.28900436
97MAPK140.27956873
98LATS10.27156343
99IRAK10.26406972
100MELK0.26126716

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.27269063
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.19460774
3Parkinsons disease_Homo sapiens_hsa050122.65125253
4Butanoate metabolism_Homo sapiens_hsa006502.61434803
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.60730003
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.52078965
7Nicotine addiction_Homo sapiens_hsa050332.43872211
8Selenocompound metabolism_Homo sapiens_hsa004502.36700161
9Fanconi anemia pathway_Homo sapiens_hsa034602.35948962
10Protein export_Homo sapiens_hsa030602.32386176
11RNA polymerase_Homo sapiens_hsa030202.27097822
12Huntingtons disease_Homo sapiens_hsa050162.25673497
13Basal transcription factors_Homo sapiens_hsa030222.14999733
14Phototransduction_Homo sapiens_hsa047442.01438023
15Tryptophan metabolism_Homo sapiens_hsa003801.86639361
16Olfactory transduction_Homo sapiens_hsa047401.76257402
17Circadian rhythm_Homo sapiens_hsa047101.74368723
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.71932026
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.70353170
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.63429924
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62718344
22Alzheimers disease_Homo sapiens_hsa050101.59742376
23Fatty acid elongation_Homo sapiens_hsa000621.58758187
24Cardiac muscle contraction_Homo sapiens_hsa042601.51251639
25Linoleic acid metabolism_Homo sapiens_hsa005911.50390377
26Non-homologous end-joining_Homo sapiens_hsa034501.49828727
27Taste transduction_Homo sapiens_hsa047421.45937158
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.45892011
29Homologous recombination_Homo sapiens_hsa034401.45606006
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.42786875
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.42501676
32Regulation of autophagy_Homo sapiens_hsa041401.38018648
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37756644
34Ribosome_Homo sapiens_hsa030101.30703423
35Cocaine addiction_Homo sapiens_hsa050301.28202240
36Caffeine metabolism_Homo sapiens_hsa002321.27693901
37beta-Alanine metabolism_Homo sapiens_hsa004101.26720997
38RNA degradation_Homo sapiens_hsa030181.25010051
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23305170
40Propanoate metabolism_Homo sapiens_hsa006401.21670107
41Morphine addiction_Homo sapiens_hsa050321.16637734
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16257509
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.14545369
44Peroxisome_Homo sapiens_hsa041461.13751029
45GABAergic synapse_Homo sapiens_hsa047271.06355831
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.04153776
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98883058
48Insulin secretion_Homo sapiens_hsa049110.92504183
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.89729476
50Nitrogen metabolism_Homo sapiens_hsa009100.86739523
51Lysine degradation_Homo sapiens_hsa003100.86387842
52Spliceosome_Homo sapiens_hsa030400.84431981
53Folate biosynthesis_Homo sapiens_hsa007900.83944798
54Base excision repair_Homo sapiens_hsa034100.83041979
55Nucleotide excision repair_Homo sapiens_hsa034200.82094191
56Serotonergic synapse_Homo sapiens_hsa047260.78816322
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78806054
58Mismatch repair_Homo sapiens_hsa034300.75190127
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75087161
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74873277
61Purine metabolism_Homo sapiens_hsa002300.74070929
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72977248
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70772723
64TGF-beta signaling pathway_Homo sapiens_hsa043500.70123781
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67341335
66Histidine metabolism_Homo sapiens_hsa003400.67119080
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66977469
68Axon guidance_Homo sapiens_hsa043600.66553536
69ABC transporters_Homo sapiens_hsa020100.66102121
70Ether lipid metabolism_Homo sapiens_hsa005650.64488160
71Glutamatergic synapse_Homo sapiens_hsa047240.64033546
72Proteasome_Homo sapiens_hsa030500.62518847
73Collecting duct acid secretion_Homo sapiens_hsa049660.60111410
74Dopaminergic synapse_Homo sapiens_hsa047280.59932558
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59607864
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58814722
77Metabolic pathways_Homo sapiens_hsa011000.58443005
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.57872835
79Steroid biosynthesis_Homo sapiens_hsa001000.56347372
80Retinol metabolism_Homo sapiens_hsa008300.56011947
81Pyrimidine metabolism_Homo sapiens_hsa002400.55705762
82Calcium signaling pathway_Homo sapiens_hsa040200.55101431
83Circadian entrainment_Homo sapiens_hsa047130.51895407
84Hedgehog signaling pathway_Homo sapiens_hsa043400.50778670
85Amphetamine addiction_Homo sapiens_hsa050310.48293028
86p53 signaling pathway_Homo sapiens_hsa041150.47004157
87RNA transport_Homo sapiens_hsa030130.45939460
88Sulfur relay system_Homo sapiens_hsa041220.42921294
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40930905
90Cholinergic synapse_Homo sapiens_hsa047250.40805917
91Chemical carcinogenesis_Homo sapiens_hsa052040.39228973
92Basal cell carcinoma_Homo sapiens_hsa052170.39115783
93One carbon pool by folate_Homo sapiens_hsa006700.37867792
94Synaptic vesicle cycle_Homo sapiens_hsa047210.32292044
95Hippo signaling pathway_Homo sapiens_hsa043900.30696172
96mRNA surveillance pathway_Homo sapiens_hsa030150.29299982
97Salivary secretion_Homo sapiens_hsa049700.27557335
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27166134
99Fatty acid degradation_Homo sapiens_hsa000710.27154598
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26402253

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