ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of timing of cell differentiation (GO:0048505)	8.27311082
2	regulation of development, heterochronic (GO:0040034)	7.57977374
3	lens development in camera-type eye (GO:0002088)	6.73503125
4	astrocyte differentiation (GO:0048708)	6.57045825
5	positive regulation of cell fate commitment (GO:0010455)	6.29572575
6	hindbrain development (GO:0030902)	6.07722755
7	regulation of phospholipid biosynthetic process (GO:0071071)	5.53727723
8	dorsal/ventral axis specification (GO:0009950)	5.52685467
9	positive regulation of neuroblast proliferation (GO:0002052)	5.47819701
10	regulation of transcription involved in cell fate commitment (GO:0060850)	5.46583244
11	replication fork processing (GO:0031297)	5.36351161
12	gland morphogenesis (GO:0022612)	4.82845191
13	regulation of cell fate specification (GO:0042659)	4.73318663
14	signal transduction involved in regulation of gene expression (GO:0023019)	4.64665440
15	embryonic camera-type eye morphogenesis (GO:0048596)	4.62932294
16	regulation of hexokinase activity (GO:1903299)	4.57042834
17	regulation of glucokinase activity (GO:0033131)	4.57042834
18	glandular epithelial cell development (GO:0002068)	4.54617315
19	pituitary gland development (GO:0021983)	4.43537127
20	glandular epithelial cell differentiation (GO:0002067)	4.37203548
21	negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)	4.34361816
22	serotonin receptor signaling pathway (GO:0007210)	4.17995887
23	DNA strand renaturation (GO:0000733)	4.03465895
24	neurotransmitter catabolic process (GO:0042135)	4.01408204
25	artery development (GO:0060840)	3.89816344
26	startle response (GO:0001964)	3.82320479
27	proteasome assembly (GO:0043248)	3.77373364
28	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.57633280
29	columnar/cuboidal epithelial cell development (GO:0002066)	3.54484999
30	neuron fate commitment (GO:0048663)	3.52367471
31	regulation of neuroblast proliferation (GO:1902692)	3.50952219
32	photoreceptor cell development (GO:0042461)	3.49225278
33	positive regulation of developmental pigmentation (GO:0048087)	3.47736619
34	spermatid nucleus differentiation (GO:0007289)	3.47357277
35	embryonic foregut morphogenesis (GO:0048617)	3.44646661
36	regulation of type B pancreatic cell apoptotic process (GO:2000674)	3.28585294
37	DNA deamination (GO:0045006)	3.24982284
38	centriole replication (GO:0007099)	3.24123314
39	regulation of cell fate commitment (GO:0010453)	3.21157725
40	eye photoreceptor cell development (GO:0042462)	3.19939485
41	chaperone-mediated protein transport (GO:0072321)	3.17092665
42	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	3.14760871
43	heart field specification (GO:0003128)	3.09699259
44	secondary heart field specification (GO:0003139)	3.09699259
45	epithelial cilium movement (GO:0003351)	3.08063506
46	single strand break repair (GO:0000012)	3.07558240
47	histone H2A acetylation (GO:0043968)	3.06462958
48	positive regulation of neural precursor cell proliferation (GO:2000179)	3.05961456
49	fusion of sperm to egg plasma membrane (GO:0007342)	3.01467775
50	cardiac left ventricle morphogenesis (GO:0003214)	3.01112335
51	negative regulation of glial cell proliferation (GO:0060253)	3.00664117
52	regulation of pigment cell differentiation (GO:0050932)	3.00478011
53	cilium morphogenesis (GO:0060271)	2.93783830
54	protein prenylation (GO:0018342)	2.92026171
55	prenylation (GO:0097354)	2.92026171
56	CTP biosynthetic process (GO:0006241)	2.90682304
57	CTP metabolic process (GO:0046036)	2.90682304
58	inner ear receptor cell development (GO:0060119)	2.89052048
59	receptor catabolic process (GO:0032801)	2.87069947
60	regulation of gene expression by genetic imprinting (GO:0006349)	2.86536419
61	limb development (GO:0060173)	2.86167143
62	appendage development (GO:0048736)	2.86167143
63	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.85429454
64	protein targeting to Golgi (GO:0000042)	2.85425042
65	negative regulation of histone acetylation (GO:0035067)	2.84580014
66	acrosome reaction (GO:0007340)	2.83561593
67	cell fate specification (GO:0001708)	2.81550186
68	smoothened signaling pathway (GO:0007224)	2.81306834
69	embryonic eye morphogenesis (GO:0048048)	2.79537389
70	negative regulation of dendrite morphogenesis (GO:0050774)	2.74116020
71	mitochondrial genome maintenance (GO:0000002)	2.74005423
72	response to epinephrine (GO:0071871)	2.73885103
73	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-	2.73285764
74	cilium movement (GO:0003341)	2.73081703
75	leukotriene biosynthetic process (GO:0019370)	2.72266667
76	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.70959934
77	oocyte development (GO:0048599)	2.70238400
78	microtubule depolymerization (GO:0007019)	2.69896460
79	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	2.69756627
80	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.69167590
81	sperm motility (GO:0030317)	2.69000246
82	negative regulation of peptidyl-lysine acetylation (GO:2000757)	2.68965236
83	multicellular organism reproduction (GO:0032504)	2.68450710
84	specification of organ identity (GO:0010092)	2.68330830
85	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.66583011
86	protein K11-linked deubiquitination (GO:0035871)	2.66561873
87	epithelial cell fate commitment (GO:0072148)	2.65982192
88	positive regulation of meiosis (GO:0045836)	2.65509156
89	fucose catabolic process (GO:0019317)	2.64481547
90	L-fucose metabolic process (GO:0042354)	2.64481547
91	L-fucose catabolic process (GO:0042355)	2.64481547
92	establishment of protein localization to Golgi (GO:0072600)	2.63503166
93	gastrulation with mouth forming second (GO:0001702)	2.61513597
94	parental behavior (GO:0060746)	2.60359667
95	positive regulation of epithelial cell differentiation (GO:0030858)	2.59065196
96	GTP biosynthetic process (GO:0006183)	2.57069085
97	maturation of 5.8S rRNA (GO:0000460)	2.56299125
98	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.56268274
99	phosphatidylethanolamine metabolic process (GO:0046337)	2.53964547
100	cornea development in camera-type eye (GO:0061303)	11.0896231

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.35428405
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.38050147
3	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.80052831
4	TAF15_26573619_Chip-Seq_HEK293_Human	2.61844146
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.59113885
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.57126163
7	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	2.52766715
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.42507591
9	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.40547859
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.17193314
11	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.08243203
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.03243590
13	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.97589965
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.96051843
15	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.89276323
16	VDR_22108803_ChIP-Seq_LS180_Human	1.89221896
17	FUS_26573619_Chip-Seq_HEK293_Human	1.89163301
18	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.88745953
19	IGF1R_20145208_ChIP-Seq_DFB_Human	1.85630105
20	ZNF274_21170338_ChIP-Seq_K562_Hela	1.84491629
21	P300_19829295_ChIP-Seq_ESCs_Human	1.82887381
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.80839449
23	HTT_18923047_ChIP-ChIP_STHdh_Human	1.73243062
24	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.72239548
25	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.72193486
26	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.68756973
27	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.66000150
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.62208558
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.58352612
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.58352612
31	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.57530061
32	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.57530061
33	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.56907861
34	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.56105905
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.54673603
36	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.53150052
37	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.52794548
38	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.51840367
39	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.51542567
40	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.48978464
41	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.48706185
42	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.45652730
43	SMAD4_21799915_ChIP-Seq_A2780_Human	1.45034817
44	AHR_22903824_ChIP-Seq_MCF-7_Human	1.44095656
45	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.42253181
46	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.40478345
47	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.39752527
48	STAT3_23295773_ChIP-Seq_U87_Human	1.39114064
49	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.38568913
50	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.38338177
51	EWS_26573619_Chip-Seq_HEK293_Human	1.36610146
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.36358705
53	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.35624802
54	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.35215709
55	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.32460911
56	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.28105802
57	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.27940216
58	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.27906478
59	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.26340704
60	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.25846244
61	EZH2_22144423_ChIP-Seq_EOC_Human	1.23900668
62	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.21427642
63	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.20766376
64	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.20647141
65	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.20516470
66	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.18793653
67	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.18101653
68	ERG_20517297_ChIP-Seq_VCAP_Human	1.17800237
69	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.15861873
70	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.15449984
71	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.14984178
72	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.14735009
73	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.12270209
74	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.11697336
75	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.11510443
76	ER_23166858_ChIP-Seq_MCF-7_Human	1.10329028
77	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.09353599
78	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.08892555
79	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.08517719
80	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.08264085
81	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.08264085
82	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.07510107
83	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.07227695
84	AR_21572438_ChIP-Seq_LNCaP_Human	1.07067302
85	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.06843984
86	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.06843984
87	RUNX2_22187159_ChIP-Seq_PCA_Human	1.06476645
88	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.05574080
89	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.04471104
90	MYC_18940864_ChIP-ChIP_HL60_Human	1.04458506
91	NANOG_20526341_ChIP-Seq_ESCs_Human	1.04406602
92	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.03728771
93	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.03533168
94	PHF8_20622853_ChIP-Seq_HELA_Human	1.02253106
95	RNF2_27304074_Chip-Seq_NSC_Mouse	1.01776533
96	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.01183082
97	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.01127102
98	TCF4_23295773_ChIP-Seq_U87_Human	0.99852331
99	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.98708684
100	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.98504483

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	7.67272936
2	MP0005257_abnormal_intraocular_pressure	6.23322222
3	MP0002638_abnormal_pupillary_reflex	5.43336823
4	MP0002938_white_spotting	5.33852826
5	MP0003136_yellow_coat_color	4.65277233
6	MP0000372_irregular_coat_pigmentation	3.82211429
7	MP0008789_abnormal_olfactory_epithelium	3.62631740
8	MP0008877_abnormal_DNA_methylation	2.89889295
9	MP0005499_abnormal_olfactory_system	2.78928194
10	MP0005394_taste/olfaction_phenotype	2.78928194
11	MP0003787_abnormal_imprinting	2.73874018
12	MP0005410_abnormal_fertilization	2.36643652
13	MP0008961_abnormal_basal_metabolism	2.14493245
14	MP0005670_abnormal_white_adipose	2.06498687
15	MP0009379_abnormal_foot_pigmentation	1.81556183
16	MP0000613_abnormal_salivary_gland	1.78530459
17	MP0003011_delayed_dark_adaptation	1.66635321
18	MP0002653_abnormal_ependyma_morphology	1.57481374
19	MP0008057_abnormal_DNA_replication	1.55664290
20	MP0002697_abnormal_eye_size	1.54973885
21	MP0002160_abnormal_reproductive_system	1.54956696
22	MP0003121_genomic_imprinting	1.43481024
23	MP0000566_synostosis	1.41644117
24	MP0002736_abnormal_nociception_after	1.39977895
25	MP0004381_abnormal_hair_follicle	1.30303088
26	MP0001968_abnormal_touch/_nociception	1.21506969
27	MP0000778_abnormal_nervous_system	1.19553851
28	MP0009780_abnormal_chondrocyte_physiolo	1.18411500
29	MP0004142_abnormal_muscle_tone	1.18354639
30	MP0003941_abnormal_skin_development	1.17505475
31	MP0003283_abnormal_digestive_organ	1.17187883
32	MP0000428_abnormal_craniofacial_morphol	1.15569109
33	MP0003937_abnormal_limbs/digits/tail_de	1.14093524
34	MP0010234_abnormal_vibrissa_follicle	1.12258678
35	MP0001440_abnormal_grooming_behavior	1.11874085
36	MP0005075_abnormal_melanosome_morpholog	1.09209872
37	MP0003718_maternal_effect	1.06392557
38	MP0002735_abnormal_chemical_nociception	1.03129117
39	MP0005084_abnormal_gallbladder_morpholo	1.02497704
40	MP0004885_abnormal_endolymph	1.00120539
41	MP0000537_abnormal_urethra_morphology	0.96113057
42	MP0003195_calcinosis	0.96016233
43	MP0003806_abnormal_nucleotide_metabolis	0.95936769
44	MP0009745_abnormal_behavioral_response	0.92236271
45	MP0005248_abnormal_Harderian_gland	0.91378744
46	MP0010678_abnormal_skin_adnexa	0.91322474
47	MP0004147_increased_porphyrin_level	0.89080618
48	MP0001324_abnormal_eye_pigmentation	0.87800425
49	MP0001919_abnormal_reproductive_system	0.87745007
50	MP0001486_abnormal_startle_reflex	0.86055871
51	MP0003959_abnormal_lean_body	0.85518444
52	MP0005253_abnormal_eye_physiology	0.84645785
53	MP0000383_abnormal_hair_follicle	0.83107033
54	MP0010386_abnormal_urinary_bladder	0.82478002
55	MP0005389_reproductive_system_phenotype	0.82451022
56	MP0005408_hypopigmentation	0.82204523
57	MP0009053_abnormal_anal_canal	0.81671669
58	MP0003119_abnormal_digestive_system	0.81551371
59	MP0002751_abnormal_autonomic_nervous	0.81360477
60	MP0005551_abnormal_eye_electrophysiolog	0.81214500
61	MP0000049_abnormal_middle_ear	0.81201434
62	MP0001944_abnormal_pancreas_morphology	0.80908745
63	MP0003938_abnormal_ear_development	0.80855661
64	MP0002837_dystrophic_cardiac_calcinosis	0.80664830
65	MP0005367_renal/urinary_system_phenotyp	0.80317910
66	MP0000516_abnormal_urinary_system	0.80317910
67	MP0005266_abnormal_metabolism	0.78299985
68	MP0002102_abnormal_ear_morphology	0.77819833
69	MP0003698_abnormal_male_reproductive	0.77398239
70	MP0005391_vision/eye_phenotype	0.74275858
71	MP0008875_abnormal_xenobiotic_pharmacok	0.74056818
72	MP0000631_abnormal_neuroendocrine_gland	0.73792545
73	MP0003755_abnormal_palate_morphology	0.73699921
74	MP0004133_heterotaxia	0.72903406
75	MP0001929_abnormal_gametogenesis	0.70252393
76	MP0002693_abnormal_pancreas_physiology	0.69180780
77	MP0005195_abnormal_posterior_eye	0.69000070
78	MP0002733_abnormal_thermal_nociception	0.68608000
79	MP0003137_abnormal_impulse_conducting	0.65461619
80	MP0001186_pigmentation_phenotype	0.64392943
81	MP0001286_abnormal_eye_development	0.63676938
82	MP0000538_abnormal_urinary_bladder	0.62785927
83	MP0002557_abnormal_social/conspecific_i	0.62528046
84	MP0002098_abnormal_vibrissa_morphology	0.60666383
85	MP0002177_abnormal_outer_ear	0.57238735
86	MP0003638_abnormal_response/metabolism_	0.56740004
87	MP0000026_abnormal_inner_ear	0.56647867
88	MP0002092_abnormal_eye_morphology	0.54386606
89	MP0002272_abnormal_nervous_system	0.54032037
90	MP0005423_abnormal_somatic_nervous	0.52225276
91	MP0001340_abnormal_eyelid_morphology	0.51632639
92	MP0002282_abnormal_trachea_morphology	0.50561063
93	MP0003950_abnormal_plasma_membrane	0.49646898
94	MP0005645_abnormal_hypothalamus_physiol	0.49148876
95	MP0010030_abnormal_orbit_morphology	0.49000971
96	MP0002067_abnormal_sensory_capabilities	0.47157549
97	MP0005535_abnormal_body_temperature	0.47011443
98	MP0000534_abnormal_ureter_morphology	0.45440258
99	MP0009046_muscle_twitch	0.44580843
100	MP0002234_abnormal_pharynx_morphology	0.44437135

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoplasia of the fovea (HP:0007750)	9.03599914
2	Aplasia/Hypoplasia of the fovea (HP:0008060)	9.03599914
3	Abnormality of the fovea (HP:0000493)	7.56873182
4	Aplasia/Hypoplasia of the macula (HP:0008059)	5.98551075
5	Aplasia/Hypoplasia affecting the retina (HP:0008061)	5.54541413
6	True hermaphroditism (HP:0010459)	4.95068733
7	Pancreatic cysts (HP:0001737)	4.55946035
8	Optic nerve hypoplasia (HP:0000609)	4.29040583
9	Pancreatic fibrosis (HP:0100732)	4.08895796
10	Congenital glaucoma (HP:0001087)	3.89211150
11	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	3.86385800
12	Anencephaly (HP:0002323)	3.84915047
13	Optic nerve coloboma (HP:0000588)	3.78401134
14	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.54281925
15	Difficulty running (HP:0009046)	3.45622258
16	Cystic liver disease (HP:0006706)	3.12820572
17	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.03340539
18	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.03340539
19	Aplasia/Hypoplasia of the tongue (HP:0010295)	3.02872460
20	Occipital encephalocele (HP:0002085)	3.01338958
21	Furrowed tongue (HP:0000221)	2.72676446
22	Abnormality of the aortic arch (HP:0012303)	2.67594922
23	Sclerocornea (HP:0000647)	2.64650815
24	Aqueductal stenosis (HP:0002410)	2.61617113
25	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.60252942
26	Mask-like facies (HP:0000298)	2.59009156
27	Posterior subcapsular cataract (HP:0007787)	2.55101140
28	Nephronophthisis (HP:0000090)	2.50394836
29	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.46228781
30	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.45567643
31	Congenital stationary night blindness (HP:0007642)	2.44607597
32	Hypoplastic pelvis (HP:0008839)	2.41000411
33	Generalized aminoaciduria (HP:0002909)	2.35667855
34	Congenital hepatic fibrosis (HP:0002612)	2.33934507
35	Short tibia (HP:0005736)	2.33096479
36	Male pseudohermaphroditism (HP:0000037)	2.31681464
37	Hip contracture (HP:0003273)	2.27952469
38	Increased corneal curvature (HP:0100692)	2.27681658
39	Keratoconus (HP:0000563)	2.27681658
40	Abnormality of midbrain morphology (HP:0002418)	2.24331413
41	Molar tooth sign on MRI (HP:0002419)	2.24331413
42	Hip dysplasia (HP:0001385)	2.21079966
43	Hypothermia (HP:0002045)	2.19998719
44	Intestinal atresia (HP:0011100)	2.18497367
45	Focal motor seizures (HP:0011153)	2.17768777
46	Bulbous nose (HP:0000414)	2.15371660
47	Attenuation of retinal blood vessels (HP:0007843)	2.14289252
48	Abnormal rod and cone electroretinograms (HP:0008323)	2.13820535
49	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.10995055
50	Abnormal spermatogenesis (HP:0008669)	2.10661789
51	Preaxial hand polydactyly (HP:0001177)	2.08562961
52	Aplasia/Hypoplasia of the lens (HP:0008063)	2.08403742
53	Keratitis (HP:0000491)	2.07354800
54	Abnormality of the corticospinal tract (HP:0002492)	2.06181715
55	Limb dystonia (HP:0002451)	2.05450269
56	Thyroid-stimulating hormone excess (HP:0002925)	2.04976033
57	Decreased central vision (HP:0007663)	2.01667779
58	Abnormal respiratory motile cilium morphology (HP:0005938)	2.00477868
59	Abnormal respiratory epithelium morphology (HP:0012253)	2.00477868
60	Postaxial foot polydactyly (HP:0001830)	2.00134470
61	Abnormal ciliary motility (HP:0012262)	1.97417401
62	Limited hip movement (HP:0008800)	1.97376506
63	Anophthalmia (HP:0000528)	1.90500974
64	Myelomeningocele (HP:0002475)	1.88966082
65	Hemiparesis (HP:0001269)	1.87885171
66	Congenital, generalized hypertrichosis (HP:0004540)	1.86983031
67	Abnormality of urine glucose concentration (HP:0011016)	1.84383819
68	Glycosuria (HP:0003076)	1.84383819
69	Microcornea (HP:0000482)	1.82434486
70	Sloping forehead (HP:0000340)	1.81370597
71	Esophageal atresia (HP:0002032)	1.79564029
72	Lipid accumulation in hepatocytes (HP:0006561)	1.78774378
73	Abnormality of the renal medulla (HP:0100957)	1.77615998
74	Holoprosencephaly (HP:0001360)	1.76740272
75	Septo-optic dysplasia (HP:0100842)	1.74441872
76	Small hand (HP:0200055)	1.73330980
77	Corneal dystrophy (HP:0001131)	1.71605345
78	Myokymia (HP:0002411)	1.71523501
79	Osteomalacia (HP:0002749)	1.70221048
80	Achilles tendon contracture (HP:0001771)	1.70198294
81	Abnormality of the parietal bone (HP:0002696)	1.70056484
82	Abnormal number of incisors (HP:0011064)	1.68728209
83	Gastrointestinal atresia (HP:0002589)	1.66683115
84	Acute necrotizing encephalopathy (HP:0006965)	1.66417486
85	Hyperphosphaturia (HP:0003109)	1.65079208
86	Macular degeneration (HP:0000608)	1.63978518
87	Thyroiditis (HP:0100646)	1.63852841
88	Absent thumb (HP:0009777)	1.62221185
89	Dandy-Walker malformation (HP:0001305)	1.61736697
90	Azoospermia (HP:0000027)	1.61600464
91	Partial duplication of the phalanx of hand (HP:0009999)	1.60480456
92	Hypoplastic ischia (HP:0003175)	1.59473344
93	Aplasia/Hypoplasia involving the vertebral column (HP:0008518)	1.59339122
94	Progressive macrocephaly (HP:0004481)	1.58332125
95	Reduced antithrombin III activity (HP:0001976)	1.56625348
96	Increased hepatocellular lipid droplets (HP:0006565)	1.55769013
97	Poor head control (HP:0002421)	1.52007998
98	Exertional dyspnea (HP:0002875)	1.51984422
99	Morphological abnormality of the middle ear (HP:0008609)	1.51526930
100	Cupped ear (HP:0000378)	1.50227859

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHB2	4.06471350
2	FRK	4.01691753
3	IRAK2	3.96436574
4	MAPK13	3.96330484
5	PTK2B	3.64636716
6	BUB1	3.59334442
7	HIPK2	3.45838995
8	CDK19	3.35694964
9	TYRO3	3.18711232
10	CCNB1	2.65871893
11	UHMK1	2.64650311
12	DYRK3	2.52820408
13	INSRR	2.41217981
14	DDR2	2.40451729
15	FGFR2	2.37391193
16	VRK2	2.08695146
17	WEE1	2.01362127
18	MARK1	1.89262753
19	STK38L	1.82382133
20	ACVR1B	1.74720308
21	PLK4	1.72915568
22	NEK2	1.44879973
23	GRK1	1.27566024
24	BMPR1B	1.16346096
25	CDK3	1.09826450
26	TLK1	1.08061840
27	ADRBK2	0.98233900
28	RPS6KA4	0.92244972
29	TAOK3	0.89335333
30	MAPK15	0.87614574
31	PASK	0.86596674
32	DYRK2	0.84858648
33	VRK1	0.82685569
34	GRK7	0.82011687
35	SGK2	0.80683091
36	WNK3	0.79109496
37	PRKCG	0.75146320
38	TTK	0.74861681
39	MOS	0.73618266
40	PLK2	0.73280765
41	SGK494	0.73278588
42	SGK223	0.73278588
43	EPHA3	0.72641163
44	TNIK	0.71667651
45	PIK3CG	0.69972596
46	ZAK	0.67550762
47	WNK1	0.67140123
48	MAP4K2	0.66924601
49	FER	0.66724484
50	MAPK7	0.62826081
51	ICK	0.61642946
52	PHKG1	0.61161462
53	PHKG2	0.61161462
54	DYRK1A	0.60892344
55	MAP3K12	0.59398545
56	RPS6KA2	0.56114808
57	TGFBR1	0.56023219
58	RPS6KA5	0.53188810
59	MST4	0.52954394
60	LATS1	0.52535164
61	DAPK2	0.49627580
62	MAP3K8	0.48664003
63	STK3	0.48021683
64	TRPM7	0.46238277
65	OXSR1	0.45991408
66	TAF1	0.45822547
67	ATM	0.45513035
68	TAOK1	0.43711634
69	OBSCN	0.43266209
70	TIE1	0.42994772
71	PRKCE	0.42291958
72	PAK3	0.39969241
73	ADRBK1	0.39615888
74	PNCK	0.39575854
75	CSNK1A1	0.39555914
76	PRKG1	0.39124931
77	FES	0.38737773
78	IRAK1	0.38086139
79	TRIM28	0.37693468
80	NEK9	0.36245360
81	SIK2	0.35276618
82	RPS6KA6	0.34451954
83	RPS6KC1	0.31959329
84	RPS6KL1	0.31959329
85	RPS6KB2	0.30611643
86	CDK7	0.30136988
87	TNK2	0.28876458
88	BRSK2	0.28537546
89	PRKCZ	0.26250748
90	MAP3K9	0.25539870
91	GRK5	0.24874110
92	ARAF	0.24732532
93	PRKACB	0.24522994
94	ATR	0.22705352
95	CDK8	0.22567316
96	BRSK1	0.21722311
97	STK24	0.21039949
98	CHEK2	0.20862025
99	RPS6KA3	0.19854053
100	SGK1	0.19712950

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	5.27756738
2	Cyanoamino acid metabolism_Homo sapiens_hsa00460	3.91129663
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.83572213
4	Caffeine metabolism_Homo sapiens_hsa00232	3.53712330
5	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	3.45076758
6	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.36622039
7	Vitamin B6 metabolism_Homo sapiens_hsa00750	3.12878400
8	Ribosome_Homo sapiens_hsa03010	2.47351053
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.45780860
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.35525923
11	Non-homologous end-joining_Homo sapiens_hsa03450	2.01536359
12	Parkinsons disease_Homo sapiens_hsa05012	2.00506364
13	Fanconi anemia pathway_Homo sapiens_hsa03460	1.77233265
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.73763647
15	Folate biosynthesis_Homo sapiens_hsa00790	1.69155165
16	Nicotine addiction_Homo sapiens_hsa05033	1.66039916
17	Steroid biosynthesis_Homo sapiens_hsa00100	1.64900811
18	Huntingtons disease_Homo sapiens_hsa05016	1.57956472
19	Calcium signaling pathway_Homo sapiens_hsa04020	1.51181106
20	Cocaine addiction_Homo sapiens_hsa05030	1.50365921
21	Alzheimers disease_Homo sapiens_hsa05010	1.46259076
22	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.40096002
23	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.39888163
24	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.38583420
25	Olfactory transduction_Homo sapiens_hsa04740	1.28145401
26	Amphetamine addiction_Homo sapiens_hsa05031	1.28116944
27	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.28089141
28	One carbon pool by folate_Homo sapiens_hsa00670	1.25113934
29	Butanoate metabolism_Homo sapiens_hsa00650	1.24270015
30	Phototransduction_Homo sapiens_hsa04744	1.22382467
31	Cardiac muscle contraction_Homo sapiens_hsa04260	1.18704785
32	Insulin secretion_Homo sapiens_hsa04911	1.12388410
33	Linoleic acid metabolism_Homo sapiens_hsa00591	1.07059818
34	Basal transcription factors_Homo sapiens_hsa03022	1.06948255
35	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.98490250
36	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.94722754
37	RNA degradation_Homo sapiens_hsa03018	0.93268230
38	Serotonergic synapse_Homo sapiens_hsa04726	0.91620664
39	Circadian entrainment_Homo sapiens_hsa04713	0.88079704
40	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.88071601
41	Homologous recombination_Homo sapiens_hsa03440	0.86831992
42	Taste transduction_Homo sapiens_hsa04742	0.86007376
43	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.85755176
44	Tryptophan metabolism_Homo sapiens_hsa00380	0.75160366
45	Retinol metabolism_Homo sapiens_hsa00830	0.71166716
46	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.70409901
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.69738576
48	Morphine addiction_Homo sapiens_hsa05032	0.69455969
49	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.68142448
50	Basal cell carcinoma_Homo sapiens_hsa05217	0.65895395
51	Selenocompound metabolism_Homo sapiens_hsa00450	0.65492488
52	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.64967312
53	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.64905244
54	Glutathione metabolism_Homo sapiens_hsa00480	0.63951452
55	Protein export_Homo sapiens_hsa03060	0.61899623
56	cAMP signaling pathway_Homo sapiens_hsa04024	0.60685583
57	Mineral absorption_Homo sapiens_hsa04978	0.60426819
58	Proteasome_Homo sapiens_hsa03050	0.60067002
59	Dopaminergic synapse_Homo sapiens_hsa04728	0.59369849
60	Nitrogen metabolism_Homo sapiens_hsa00910	0.58359723
61	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.58257159
62	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.58137072
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.55116132
64	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.54471812
65	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.54253334
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.49831785
67	Metabolic pathways_Homo sapiens_hsa01100	0.49395428
68	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.48955896
69	RNA transport_Homo sapiens_hsa03013	0.47335258
70	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.46839279
71	Alcoholism_Homo sapiens_hsa05034	0.46351287
72	Cholinergic synapse_Homo sapiens_hsa04725	0.45964535
73	Renin-angiotensin system_Homo sapiens_hsa04614	0.44697674
74	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.43183067
75	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.41915134
76	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.39947890
77	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.38770187
78	Tyrosine metabolism_Homo sapiens_hsa00350	0.38391180
79	GABAergic synapse_Homo sapiens_hsa04727	0.38338563
80	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.35799572
81	Ether lipid metabolism_Homo sapiens_hsa00565	0.34634567
82	Propanoate metabolism_Homo sapiens_hsa00640	0.34413484
83	Gastric acid secretion_Homo sapiens_hsa04971	0.33482602
84	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.33336125
85	Oocyte meiosis_Homo sapiens_hsa04114	0.33181843
86	Tight junction_Homo sapiens_hsa04530	0.32975055
87	Circadian rhythm_Homo sapiens_hsa04710	0.30697845
88	Bile secretion_Homo sapiens_hsa04976	0.29909902
89	Glutamatergic synapse_Homo sapiens_hsa04724	0.29435873
90	Arginine and proline metabolism_Homo sapiens_hsa00330	0.26949175
91	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.26786384
92	Base excision repair_Homo sapiens_hsa03410	0.25146573
93	Wnt signaling pathway_Homo sapiens_hsa04310	0.24936864
94	Melanogenesis_Homo sapiens_hsa04916	0.24874345
95	Hippo signaling pathway_Homo sapiens_hsa04390	0.24455240
96	Pyruvate metabolism_Homo sapiens_hsa00620	0.24366792
97	Purine metabolism_Homo sapiens_hsa00230	0.24137969
98	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.23680199
99	Phenylalanine metabolism_Homo sapiens_hsa00360	0.21019755
100	Salivary secretion_Homo sapiens_hsa04970	0.20132776

BRD7P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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