ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	6.04033748
2	positive regulation of mitochondrial fission (GO:0090141)	4.93457790
3	neuron cell-cell adhesion (GO:0007158)	4.89071486
4	presynaptic membrane assembly (GO:0097105)	4.78404835
5	positive regulation of action potential (GO:0045760)	4.72805121
6	nucleobase catabolic process (GO:0046113)	4.70544711
7	negative regulation of synaptic transmission, GABAergic (GO:0032229)	4.65127900
8	protein localization to synapse (GO:0035418)	4.45789730
9	glycosphingolipid biosynthetic process (GO:0006688)	4.41251733
10	synaptic vesicle exocytosis (GO:0016079)	4.31927136
11	sequestering of actin monomers (GO:0042989)	4.16624271
12	establishment of mitochondrion localization (GO:0051654)	4.15493527
13	presynaptic membrane organization (GO:0097090)	4.08115701
14	gamma-aminobutyric acid transport (GO:0015812)	3.98410911
15	DNA double-strand break processing (GO:0000729)	3.92202226
16	neurotransmitter-gated ion channel clustering (GO:0072578)	3.89623888
17	postsynaptic membrane organization (GO:0001941)	3.85973562
18	neurotransmitter catabolic process (GO:0042135)	3.81796302
19	protein insertion into membrane (GO:0051205)	3.79267251
20	synapse assembly (GO:0007416)	3.78844069
21	protein polyglutamylation (GO:0018095)	3.70933626
22	vocalization behavior (GO:0071625)	3.66462061
23	L-serine transport (GO:0015825)	3.63109890
24	epithelial cilium movement (GO:0003351)	3.54493822
25	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	3.49402969
26	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	3.49402969
27	C4-dicarboxylate transport (GO:0015740)	3.48409969
28	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	3.45606194
29	nonmotile primary cilium assembly (GO:0035058)	3.43714293
30	organelle disassembly (GO:1903008)	3.37844138
31	behavioral response to nicotine (GO:0035095)	3.35678415
32	proline transport (GO:0015824)	3.34138647
33	positive regulation of dendritic spine morphogenesis (GO:0061003)	3.32238827
34	regulation of synapse structural plasticity (GO:0051823)	3.29818804
35	metallo-sulfur cluster assembly (GO:0031163)	3.27809809
36	iron-sulfur cluster assembly (GO:0016226)	3.27809809
37	regulation of synaptic vesicle transport (GO:1902803)	3.25336651
38	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.23728586
39	regulation of mitochondrial fission (GO:0090140)	3.22954786
40	regulation of synaptic vesicle exocytosis (GO:2000300)	3.20976434
41	glutamate secretion (GO:0014047)	3.20408239
42	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.19394243
43	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.18279363
44	pyrimidine dimer repair (GO:0006290)	3.17478733
45	cell migration in hindbrain (GO:0021535)	3.17376021
46	ribonucleoprotein complex disassembly (GO:0032988)	3.14149727
47	axoneme assembly (GO:0035082)	3.13415953
48	regulation of action potential (GO:0098900)	3.13105630
49	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	3.12959078
50	sialylation (GO:0097503)	3.08813418
51	negative regulation of DNA recombination (GO:0045910)	3.07247424
52	regulation of cilium movement (GO:0003352)	3.06859058
53	positive regulation of synapse assembly (GO:0051965)	3.06269872
54	forebrain neuron differentiation (GO:0021879)	3.04149513
55	cullin deneddylation (GO:0010388)	3.03510065
56	mitochondrion transport along microtubule (GO:0047497)	3.01108686
57	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	3.01108686
58	succinate metabolic process (GO:0006105)	3.00475700
59	synaptic transmission, glutamatergic (GO:0035249)	3.00218623
60	hippocampus development (GO:0021766)	2.99954770
61	exploration behavior (GO:0035640)	2.99307226
62	dendritic spine morphogenesis (GO:0060997)	2.94617798
63	negative regulation of telomere maintenance (GO:0032205)	2.91005226
64	neurotransmitter biosynthetic process (GO:0042136)	2.90665825
65	serine transport (GO:0032329)	2.90412481
66	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.89649056
67	cilium morphogenesis (GO:0060271)	2.89009842
68	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.88441860
69	intraciliary transport (GO:0042073)	2.86681667
70	inner ear receptor stereocilium organization (GO:0060122)	2.85459547
71	ganglioside metabolic process (GO:0001573)	2.83462120
72	auditory behavior (GO:0031223)	2.82184381
73	cilium movement (GO:0003341)	2.81935515
74	synaptic vesicle maturation (GO:0016188)	2.81359194
75	negative regulation of response to food (GO:0032096)	2.78796281
76	negative regulation of appetite (GO:0032099)	2.78796281
77	protein localization to cilium (GO:0061512)	2.78459914
78	retinal ganglion cell axon guidance (GO:0031290)	2.78193498
79	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.77976473
80	startle response (GO:0001964)	2.77343900
81	adult feeding behavior (GO:0008343)	2.77185866
82	neurotransmitter metabolic process (GO:0042133)	2.76927376
83	protein-cofactor linkage (GO:0018065)	2.76624802
84	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.75606430
85	neuron-neuron synaptic transmission (GO:0007270)	2.75568631
86	melanosome transport (GO:0032402)	2.74758926
87	regulation of dendritic spine morphogenesis (GO:0061001)	2.73634434
88	intra-Golgi vesicle-mediated transport (GO:0006891)	2.70925803
89	glycolipid biosynthetic process (GO:0009247)	2.69559894
90	dendrite morphogenesis (GO:0048813)	2.69461481
91	synapse organization (GO:0050808)	2.68972298
92	establishment of melanosome localization (GO:0032401)	2.68945708
93	protein deneddylation (GO:0000338)	2.67867342
94	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.65512064
95	limb bud formation (GO:0060174)	2.64733900
96	neuronal action potential (GO:0019228)	2.62322342
97	pigment granule transport (GO:0051904)	2.62161310
98	melanosome localization (GO:0032400)	2.61706441
99	reflex (GO:0060004)	2.60372531
100	acrosome reaction (GO:0007340)	2.59998056

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	4.28546778
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.99507248
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.92583372
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.66132580
5	GBX2_23144817_ChIP-Seq_PC3_Human	3.46683637
6	IGF1R_20145208_ChIP-Seq_DFB_Human	3.04279521
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.82023261
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.77834007
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.70330874
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.64058410
11	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.56297821
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.52542960
13	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.28793286
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.27702279
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.20241441
16	FUS_26573619_Chip-Seq_HEK293_Human	2.12309183
17	EWS_26573619_Chip-Seq_HEK293_Human	2.05510074
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.99172240
19	VDR_22108803_ChIP-Seq_LS180_Human	1.98718344
20	REST_21632747_ChIP-Seq_MESCs_Mouse	1.96357910
21	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.92694631
22	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.81873255
23	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.80809085
24	P300_19829295_ChIP-Seq_ESCs_Human	1.78754986
25	RNF2_27304074_Chip-Seq_NSC_Mouse	1.76016261
26	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.68721916
27	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.68624227
28	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.65449578
29	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.63168442
30	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.61603419
31	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.59104285
32	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.57879806
33	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.57284029
34	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.56292050
35	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.53543303
36	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.52835469
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.50611279
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.50611279
39	SMAD4_21799915_ChIP-Seq_A2780_Human	1.49791652
40	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.45058412
41	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.44835930
42	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.41077963
43	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.38912208
44	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.37460292
45	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.36840893
46	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.33760508
47	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.33348452
48	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.31998608
49	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.31918591
50	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.30102179
51	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.29665254
52	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.26119547
53	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.25542480
54	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.21609909
55	STAT3_23295773_ChIP-Seq_U87_Human	1.21247108
56	AR_25329375_ChIP-Seq_VCAP_Human	1.19442255
57	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.19058912
58	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.17878523
59	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.17468622
60	TP53_22573176_ChIP-Seq_HFKS_Human	1.16506316
61	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.15753111
62	ER_23166858_ChIP-Seq_MCF-7_Human	1.15574775
63	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.14420125
64	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.14199772
65	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.13375346
66	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.12102635
67	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.11877611
68	MYC_18940864_ChIP-ChIP_HL60_Human	1.09701191
69	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.08951153
70	JUN_21703547_ChIP-Seq_K562_Human	1.08822104
71	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.08334552
72	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.08288892
73	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.07881352
74	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.07792019
75	ELK1_19687146_ChIP-ChIP_HELA_Human	1.06930182
76	VDR_23849224_ChIP-Seq_CD4+_Human	1.05854782
77	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.04614380
78	IRF1_19129219_ChIP-ChIP_H3396_Human	1.03497614
79	TCF4_23295773_ChIP-Seq_U87_Human	1.03416240
80	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.01560036
81	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.01269558
82	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.00877277
83	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.00413386
84	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.00348635
85	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.00069013
86	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.99611355
87	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.99321462
88	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.97391182
89	HTT_18923047_ChIP-ChIP_STHdh_Human	0.95188909
90	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.94327426
91	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.93318303
92	NCOR_22424771_ChIP-Seq_293T_Human	0.93263252
93	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.92984107
94	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.92198670
95	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.92117576
96	RUNX2_22187159_ChIP-Seq_PCA_Human	0.91837766
97	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.90401072
98	TCF4_22108803_ChIP-Seq_LS180_Human	0.90306347
99	TP53_18474530_ChIP-ChIP_U2OS_Human	0.89719273
100	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.88479291

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001529_abnormal_vocalization	3.83907957
2	MP0004270_analgesia	3.05193717
3	MP0008789_abnormal_olfactory_epithelium	2.97907059
4	MP0005394_taste/olfaction_phenotype	2.95758144
5	MP0005499_abnormal_olfactory_system	2.95758144
6	MP0003880_abnormal_central_pattern	2.92711311
7	MP0002822_catalepsy	2.70612632
8	MP0006276_abnormal_autonomic_nervous	2.47142231
9	MP0000778_abnormal_nervous_system	2.45088835
10	MP0009046_muscle_twitch	2.40883240
11	MP0001984_abnormal_olfaction	2.39620037
12	MP0004859_abnormal_synaptic_plasticity	2.38587994
13	MP0002102_abnormal_ear_morphology	2.33424218
14	MP0003787_abnormal_imprinting	2.24892055
15	MP0002234_abnormal_pharynx_morphology	2.24532919
16	MP0001188_hyperpigmentation	2.18160795
17	MP0003635_abnormal_synaptic_transmissio	2.13784096
18	MP0005248_abnormal_Harderian_gland	2.05961953
19	MP0009745_abnormal_behavioral_response	2.01769107
20	MP0000516_abnormal_urinary_system	1.89659099
21	MP0005367_renal/urinary_system_phenotyp	1.89659099
22	MP0008877_abnormal_DNA_methylation	1.87855060
23	MP0001486_abnormal_startle_reflex	1.81819015
24	MP0002638_abnormal_pupillary_reflex	1.81246754
25	MP0002064_seizures	1.78896767
26	MP0002272_abnormal_nervous_system	1.76516473
27	MP0002063_abnormal_learning/memory/cond	1.71982612
28	MP0001968_abnormal_touch/_nociception	1.71254769
29	MP0004043_abnormal_pH_regulation	1.67870031
30	MP0002736_abnormal_nociception_after	1.67478380
31	MP0002734_abnormal_mechanical_nocicepti	1.66966848
32	MP0000569_abnormal_digit_pigmentation	1.65366613
33	MP0002572_abnormal_emotion/affect_behav	1.63094481
34	MP0008058_abnormal_DNA_repair	1.53736610
35	MP0004811_abnormal_neuron_physiology	1.52242284
36	MP0004133_heterotaxia	1.47166194
37	MP0002909_abnormal_adrenal_gland	1.46987533
38	MP0005551_abnormal_eye_electrophysiolog	1.44954360
39	MP0002184_abnormal_innervation	1.38333162
40	MP0001905_abnormal_dopamine_level	1.37075149
41	MP0005253_abnormal_eye_physiology	1.35247313
42	MP0002735_abnormal_chemical_nociception	1.34841745
43	MP0001986_abnormal_taste_sensitivity	1.33538916
44	MP0006072_abnormal_retinal_apoptosis	1.33257435
45	MP0004924_abnormal_behavior	1.31278467
46	MP0005386_behavior/neurological_phenoty	1.31278467
47	MP0002751_abnormal_autonomic_nervous	1.30731529
48	MP0003890_abnormal_embryonic-extraembry	1.30379380
49	MP0003941_abnormal_skin_development	1.30101784
50	MP0003385_abnormal_body_wall	1.28711718
51	MP0003119_abnormal_digestive_system	1.28390158
52	MP0002882_abnormal_neuron_morphology	1.26900796
53	MP0000955_abnormal_spinal_cord	1.26496994
54	MP0005423_abnormal_somatic_nervous	1.25719479
55	MP0002557_abnormal_social/conspecific_i	1.25310526
56	MP0003122_maternal_imprinting	1.22398913
57	MP0002277_abnormal_respiratory_mucosa	1.22344918
58	MP0005645_abnormal_hypothalamus_physiol	1.21569560
59	MP0000013_abnormal_adipose_tissue	1.18362595
60	MP0003121_genomic_imprinting	1.17293771
61	MP0002752_abnormal_somatic_nervous	1.17150053
62	MP0002733_abnormal_thermal_nociception	1.15564087
63	MP0000049_abnormal_middle_ear	1.13108598
64	MP0002067_abnormal_sensory_capabilities	1.11101697
65	MP0004885_abnormal_endolymph	1.09149512
66	MP0002837_dystrophic_cardiac_calcinosis	1.07919112
67	MP0002069_abnormal_eating/drinking_beha	1.07682552
68	MP0001270_distended_abdomen	1.06522640
69	MP0001970_abnormal_pain_threshold	1.06106944
70	MP0008995_early_reproductive_senescence	1.06054743
71	MP0002653_abnormal_ependyma_morphology	1.02702667
72	MP0004742_abnormal_vestibular_system	1.01368516
73	MP0002090_abnormal_vision	1.01177876
74	MP0002066_abnormal_motor_capabilities/c	0.97641976
75	MP0003221_abnormal_cardiomyocyte_apopto	0.96278139
76	MP0004142_abnormal_muscle_tone	0.95818326
77	MP0002233_abnormal_nose_morphology	0.95728441
78	MP0002160_abnormal_reproductive_system	0.93463422
79	MP0000026_abnormal_inner_ear	0.92231279
80	MP0001177_atelectasis	0.91069638
81	MP0008961_abnormal_basal_metabolism	0.87679089
82	MP0005266_abnormal_metabolism	0.84846528
83	MP0003938_abnormal_ear_development	0.83414609
84	MP0002152_abnormal_brain_morphology	0.82869980
85	MP0003011_delayed_dark_adaptation	0.82532917
86	MP0002229_neurodegeneration	0.78905470
87	MP0005195_abnormal_posterior_eye	0.78685133
88	MP0000631_abnormal_neuroendocrine_gland	0.77918081
89	MP0003879_abnormal_hair_cell	0.77766256
90	MP0003861_abnormal_nervous_system	0.75567959
91	MP0003646_muscle_fatigue	0.74712215
92	MP0003786_premature_aging	0.72334371
93	MP0003698_abnormal_male_reproductive	0.72304647
94	MP0003755_abnormal_palate_morphology	0.71778361
95	MP0005171_absent_coat_pigmentation	0.70358683
96	MP0005389_reproductive_system_phenotype	0.70088286
97	MP0003656_abnormal_erythrocyte_physiolo	0.67505254
98	MP0002938_white_spotting	0.67298285
99	MP0004215_abnormal_myocardial_fiber	0.66920469
100	MP0003633_abnormal_nervous_system	0.66093841

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Split foot (HP:0001839)	4.27097943
2	Medial flaring of the eyebrow (HP:0010747)	3.96198666
3	Gait imbalance (HP:0002141)	3.59890843
4	Pancreatic fibrosis (HP:0100732)	3.57066398
5	Pancreatic cysts (HP:0001737)	3.50210019
6	Nephrogenic diabetes insipidus (HP:0009806)	3.36432238
7	Congenital primary aphakia (HP:0007707)	3.36351744
8	Oligodactyly (hands) (HP:0001180)	3.36229269
9	3-Methylglutaconic aciduria (HP:0003535)	3.30910897
10	True hermaphroditism (HP:0010459)	3.14819711
11	Abnormality of the labia minora (HP:0012880)	3.05088976
12	Hypsarrhythmia (HP:0002521)	2.98251877
13	Genital tract atresia (HP:0001827)	2.97650818
14	Pendular nystagmus (HP:0012043)	2.84330220
15	Epileptiform EEG discharges (HP:0011182)	2.83780928
16	EEG with generalized epileptiform discharges (HP:0011198)	2.83564747
17	Nephronophthisis (HP:0000090)	2.81653649
18	Thyroid-stimulating hormone excess (HP:0002925)	2.76200679
19	Vaginal atresia (HP:0000148)	2.70254518
20	Limb dystonia (HP:0002451)	2.59446600
21	Occipital encephalocele (HP:0002085)	2.57478781
22	Cortical dysplasia (HP:0002539)	2.57348738
23	Epileptic encephalopathy (HP:0200134)	2.51884004
24	Pachygyria (HP:0001302)	2.49015626
25	Spastic tetraplegia (HP:0002510)	2.46344049
26	Lissencephaly (HP:0001339)	2.43786167
27	Amyotrophic lateral sclerosis (HP:0007354)	2.42205420
28	Renal cortical cysts (HP:0000803)	2.39081540
29	Postaxial hand polydactyly (HP:0001162)	2.38592012
30	Acute necrotizing encephalopathy (HP:0006965)	2.36042296
31	Neoplasm of the adrenal cortex (HP:0100641)	2.35890085
32	Myokymia (HP:0002411)	2.31904426
33	Focal motor seizures (HP:0011153)	2.30497781
34	Poor coordination (HP:0002370)	2.29974196
35	Tubulointerstitial nephritis (HP:0001970)	2.28942576
36	Hyperglycinemia (HP:0002154)	2.28083654
37	Dialeptic seizures (HP:0011146)	2.26958082
38	Abnormality of the renal medulla (HP:0100957)	2.26820315
39	Abnormality of midbrain morphology (HP:0002418)	2.26380606
40	Molar tooth sign on MRI (HP:0002419)	2.26380606
41	Polyphagia (HP:0002591)	2.25850948
42	Specific learning disability (HP:0001328)	2.24396481
43	Oligodactyly (HP:0012165)	2.24167904
44	Postaxial foot polydactyly (HP:0001830)	2.23336455
45	Progressive macrocephaly (HP:0004481)	2.18417660
46	Status epilepticus (HP:0002133)	2.17676004
47	Drooling (HP:0002307)	2.17315235
48	Hyperventilation (HP:0002883)	2.16632985
49	Cutaneous melanoma (HP:0012056)	2.16011296
50	Abnormal mitochondria in muscle tissue (HP:0008316)	2.15352739
51	Hepatoblastoma (HP:0002884)	2.14314976
52	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.14079629
53	Hypoplasia of the brainstem (HP:0002365)	2.14079629
54	Abnormality of the renal cortex (HP:0011035)	2.10986730
55	Atonic seizures (HP:0010819)	2.10744078
56	Long foot (HP:0001833)	2.09491146
57	Neoplasm of the adrenal gland (HP:0100631)	2.07031524
58	Inability to walk (HP:0002540)	2.06324978
59	Muscular hypotonia of the trunk (HP:0008936)	2.05303426
60	Acute encephalopathy (HP:0006846)	2.05279909
61	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.04786038
62	Focal seizures (HP:0007359)	2.02845515
63	Absent speech (HP:0001344)	2.02237251
64	Increased hepatocellular lipid droplets (HP:0006565)	2.02221765
65	Fetal akinesia sequence (HP:0001989)	2.01912438
66	Progressive cerebellar ataxia (HP:0002073)	2.00671108
67	Scrotal hypoplasia (HP:0000046)	1.99078488
68	Hypoplasia of the corpus callosum (HP:0002079)	1.98062889
69	Peripheral hypomyelination (HP:0007182)	1.96998042
70	Generalized myoclonic seizures (HP:0002123)	1.95523858
71	Excessive salivation (HP:0003781)	1.94868045
72	Mitochondrial inheritance (HP:0001427)	1.94059931
73	Cystic liver disease (HP:0006706)	1.93111207
74	Abnormal respiratory motile cilium morphology (HP:0005938)	1.93069240
75	Abnormal respiratory epithelium morphology (HP:0012253)	1.93069240
76	Sclerocornea (HP:0000647)	1.92597307
77	Narrow forehead (HP:0000341)	1.92156947
78	Decreased testicular size (HP:0008734)	1.91285992
79	Labial hypoplasia (HP:0000066)	1.90833556
80	Intestinal atresia (HP:0011100)	1.90051085
81	Anencephaly (HP:0002323)	1.89704995
82	CNS hypomyelination (HP:0003429)	1.89537357
83	Methylmalonic acidemia (HP:0002912)	1.86185899
84	Abnormality of the corticospinal tract (HP:0002492)	1.86155947
85	Rimmed vacuoles (HP:0003805)	1.84632418
86	Abnormality of the labia (HP:0000058)	1.84572044
87	Volvulus (HP:0002580)	1.83900833
88	Lipid accumulation in hepatocytes (HP:0006561)	1.83310850
89	Spastic gait (HP:0002064)	1.81015739
90	Broad foot (HP:0001769)	1.79685034
91	Double outlet right ventricle (HP:0001719)	1.78721043
92	Congenital malformation of the right heart (HP:0011723)	1.78721043
93	Abnormality of lateral ventricle (HP:0030047)	1.75130386
94	Furrowed tongue (HP:0000221)	1.74700254
95	Absence seizures (HP:0002121)	1.74664939
96	Retinal dysplasia (HP:0007973)	1.74232246
97	Cerebral hypomyelination (HP:0006808)	1.74002466
98	Failure to thrive in infancy (HP:0001531)	1.73507955
99	Midline defect of the nose (HP:0004122)	1.73223182
100	Polymicrogyria (HP:0002126)	1.72335943

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCR	4.29770535
2	TAOK3	3.87744706
3	MAP3K4	3.72876487
4	TRIM28	3.61421958
5	MARK1	3.52409047
6	PIM2	3.10614495
7	MAP2K7	3.09106129
8	PINK1	3.06015244
9	WNK3	2.99849568
10	CASK	2.89960175
11	MAPK13	2.86248808
12	MAP4K2	2.64452190
13	FRK	2.06549607
14	ERBB3	2.03130339
15	DYRK1B	1.94564756
16	DYRK2	1.70994037
17	ZAK	1.58726035
18	MAP2K4	1.55100872
19	CSNK1G3	1.53455792
20	CSNK1A1L	1.50009274
21	BCKDK	1.46882211
22	CSNK1G2	1.41592949
23	NTRK2	1.35099980
24	CSNK1G1	1.31654575
25	TXK	1.20287980
26	SIK3	1.19744927
27	FGFR2	1.19041800
28	SIK2	1.17495064
29	EPHA4	1.16934275
30	CCNB1	1.14149404
31	PHKG2	1.04809994
32	PHKG1	1.04809994
33	ADRBK2	1.00181230
34	DYRK1A	0.97398156
35	PRKCE	0.95855367
36	PLK2	0.92771804
37	EPHA3	0.92149988
38	PAK6	0.89753755
39	LIMK1	0.88869026
40	DYRK3	0.86636178
41	MAP3K5	0.86210156
42	DAPK2	0.83206213
43	CDK14	0.82585383
44	SRPK1	0.81948306
45	BMPR1B	0.81512961
46	PRKCG	0.77678930
47	PAK3	0.77045123
48	CAMK2B	0.75996985
49	CAMK2A	0.75718974
50	UHMK1	0.73959555
51	KSR1	0.71104679
52	CDK5	0.70369325
53	CDK3	0.67963527
54	VRK1	0.67450825
55	MINK1	0.65631821
56	PRKD3	0.61296317
57	RPS6KA4	0.60731733
58	PLK3	0.55926289
59	PKN1	0.55874862
60	TESK1	0.55723219
61	CSNK1A1	0.55067619
62	PRKAA1	0.55054724
63	CDK18	0.53290744
64	NTRK3	0.51900701
65	DAPK1	0.50382577
66	CAMKK2	0.50171612
67	CAMK2G	0.49099701
68	PRKCZ	0.48545085
69	PRKACB	0.48312947
70	OXSR1	0.48219957
71	BUB1	0.47211647
72	TNIK	0.47008044
73	INSRR	0.46480361
74	MAP3K6	0.45597999
75	RPS6KA5	0.45023102
76	DAPK3	0.44790556
77	GRK1	0.44396287
78	PRKACA	0.44288232
79	CDK19	0.42420854
80	CAMK4	0.42278145
81	CSNK1D	0.41359906
82	CDK15	0.41187720
83	MAPK4	0.40550545
84	CSNK1E	0.39899898
85	CDK11A	0.37456069
86	EPHB1	0.36549675
87	CDK6	0.36377782
88	PIM1	0.31222871
89	PLK1	0.30279827
90	NME1	0.30261999
91	MAPKAPK3	0.28960405
92	NUAK1	0.25734909
93	PIK3CA	0.25675194
94	CAMK2D	0.25579942
95	ATR	0.25307815
96	EPHB2	0.23940430
97	MAPK9	0.22460896
98	RPS6KA3	0.21831846
99	PRKACG	0.20703630
100	STK16	0.19631984

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	4.38949692
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.80235318
3	GABAergic synapse_Homo sapiens_hsa04727	3.15148858
4	Synaptic vesicle cycle_Homo sapiens_hsa04721	3.05221485
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.62209585
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.53246732
7	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.42328157
8	Collecting duct acid secretion_Homo sapiens_hsa04966	2.17872019
9	Taste transduction_Homo sapiens_hsa04742	2.16690251
10	Parkinsons disease_Homo sapiens_hsa05012	2.16164233
11	Morphine addiction_Homo sapiens_hsa05032	2.13784090
12	Basal transcription factors_Homo sapiens_hsa03022	1.82057967
13	Butanoate metabolism_Homo sapiens_hsa00650	1.80509491
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.78596646
15	Circadian entrainment_Homo sapiens_hsa04713	1.67705380
16	Dopaminergic synapse_Homo sapiens_hsa04728	1.66668875
17	Glutamatergic synapse_Homo sapiens_hsa04724	1.66583653
18	Protein export_Homo sapiens_hsa03060	1.66051139
19	Regulation of autophagy_Homo sapiens_hsa04140	1.56258211
20	Cocaine addiction_Homo sapiens_hsa05030	1.53739741
21	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.46045053
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.44423886
23	Huntingtons disease_Homo sapiens_hsa05016	1.44256259
24	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.40132437
25	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.37878030
26	Axon guidance_Homo sapiens_hsa04360	1.36040521
27	Phototransduction_Homo sapiens_hsa04744	1.34403739
28	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.34107638
29	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.27912273
30	Steroid biosynthesis_Homo sapiens_hsa00100	1.26753000
31	RNA polymerase_Homo sapiens_hsa03020	1.24724606
32	Linoleic acid metabolism_Homo sapiens_hsa00591	1.23865004
33	Alzheimers disease_Homo sapiens_hsa05010	1.23292062
34	Sulfur relay system_Homo sapiens_hsa04122	1.20124982
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.18759355
36	Olfactory transduction_Homo sapiens_hsa04740	1.17694966
37	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.14628774
38	Propanoate metabolism_Homo sapiens_hsa00640	1.13482969
39	Amphetamine addiction_Homo sapiens_hsa05031	1.12444598
40	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.07529345
41	Vibrio cholerae infection_Homo sapiens_hsa05110	1.07158920
42	Serotonergic synapse_Homo sapiens_hsa04726	1.04311836
43	RNA degradation_Homo sapiens_hsa03018	1.00773467
44	Insulin secretion_Homo sapiens_hsa04911	1.00277449
45	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.98060148
46	Circadian rhythm_Homo sapiens_hsa04710	0.97056486
47	beta-Alanine metabolism_Homo sapiens_hsa00410	0.96579186
48	Ether lipid metabolism_Homo sapiens_hsa00565	0.96210409
49	Oocyte meiosis_Homo sapiens_hsa04114	0.93859816
50	Cardiac muscle contraction_Homo sapiens_hsa04260	0.90919500
51	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.83217538
52	Long-term depression_Homo sapiens_hsa04730	0.82713299
53	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.82576877
54	Cholinergic synapse_Homo sapiens_hsa04725	0.80520178
55	Fatty acid elongation_Homo sapiens_hsa00062	0.77118300
56	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.74872101
57	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.74475593
58	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.74273780
59	Folate biosynthesis_Homo sapiens_hsa00790	0.73427737
60	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.70812995
61	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.69003386
62	Gap junction_Homo sapiens_hsa04540	0.66862288
63	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.66288869
64	RNA transport_Homo sapiens_hsa03013	0.66273328
65	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.63637953
66	Nucleotide excision repair_Homo sapiens_hsa03420	0.61190797
67	Alcoholism_Homo sapiens_hsa05034	0.61184000
68	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.59012274
69	Caffeine metabolism_Homo sapiens_hsa00232	0.56260957
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.56221816
71	Homologous recombination_Homo sapiens_hsa03440	0.55680125
72	Type II diabetes mellitus_Homo sapiens_hsa04930	0.53313025
73	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.52481019
74	Metabolic pathways_Homo sapiens_hsa01100	0.51943198
75	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.49300694
76	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.47810426
77	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.47681364
78	Base excision repair_Homo sapiens_hsa03410	0.47269195
79	Proteasome_Homo sapiens_hsa03050	0.44566911
80	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.42043766
81	Retinol metabolism_Homo sapiens_hsa00830	0.39961635
82	Peroxisome_Homo sapiens_hsa04146	0.39088515
83	Salivary secretion_Homo sapiens_hsa04970	0.38150931
84	Gastric acid secretion_Homo sapiens_hsa04971	0.37115250
85	Pyrimidine metabolism_Homo sapiens_hsa00240	0.36766976
86	mRNA surveillance pathway_Homo sapiens_hsa03015	0.36490065
87	Ras signaling pathway_Homo sapiens_hsa04014	0.35941640
88	Chemical carcinogenesis_Homo sapiens_hsa05204	0.35639843
89	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.34993890
90	p53 signaling pathway_Homo sapiens_hsa04115	0.34326123
91	Arginine and proline metabolism_Homo sapiens_hsa00330	0.33339814
92	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.33105768
93	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.32066569
94	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.31756959
95	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.31417250
96	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.31340560
97	Purine metabolism_Homo sapiens_hsa00230	0.30767734
98	Calcium signaling pathway_Homo sapiens_hsa04020	0.29923478
99	Salmonella infection_Homo sapiens_hsa05132	0.28382850
100	Melanoma_Homo sapiens_hsa05218	0.27561199

BRD9P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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