BRDT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: BRDT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence (a cluster of proline, glutamic acid, serine, and threonine residues), characteristic of proteins that undergo rapid intracellular degradation. The bromodomain is found in proteins that regulate transcription. Several transcript variants encoding multiple isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.99788380
2regulation of meiosis I (GO:0060631)7.39307206
3* male meiosis (GO:0007140)6.80006686
4DNA methylation involved in gamete generation (GO:0043046)6.77469588
5synaptonemal complex assembly (GO:0007130)6.72285044
6synaptonemal complex organization (GO:0070193)6.66611617
7fusion of sperm to egg plasma membrane (GO:0007342)6.29425436
8cilium or flagellum-dependent cell motility (GO:0001539)6.21233076
9axonemal dynein complex assembly (GO:0070286)5.79824753
10multicellular organism reproduction (GO:0032504)5.74081061
11meiotic cell cycle (GO:0051321)5.69816057
12monoubiquitinated protein deubiquitination (GO:0035520)5.49684405
13epithelial cilium movement (GO:0003351)5.33748906
14regulation of meiosis (GO:0040020)5.30022120
15microtubule severing (GO:0051013)5.19545954
16regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.13894483
17sperm motility (GO:0030317)5.00744420
18cilium movement (GO:0003341)4.82862958
19plasma membrane fusion (GO:0045026)4.77032867
20synapsis (GO:0007129)4.68645166
21spermatid development (GO:0007286)4.64685753
22mitotic metaphase plate congression (GO:0007080)4.63724253
23* meiotic nuclear division (GO:0007126)4.61074502
24female gamete generation (GO:0007292)4.58959838
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.58817199
26motile cilium assembly (GO:0044458)4.55189695
27regulation of cilium movement (GO:0003352)4.55091102
28acrosome assembly (GO:0001675)4.54841919
29acrosome reaction (GO:0007340)4.49861810
30sperm-egg recognition (GO:0035036)4.43651438
31chromosome organization involved in meiosis (GO:0070192)4.41508140
32reproduction (GO:0000003)4.38583909
33microtubule depolymerization (GO:0007019)4.37984969
34regulation of meiotic cell cycle (GO:0051445)4.31846443
35negative regulation of hormone biosynthetic process (GO:0032353)4.31682827
36negative regulation of hormone metabolic process (GO:0032351)4.31682827
37single fertilization (GO:0007338)4.30347310
38fertilization (GO:0009566)4.21388366
39negative regulation of meiosis (GO:0045835)4.16365084
40binding of sperm to zona pellucida (GO:0007339)4.11838830
41glycerophospholipid catabolic process (GO:0046475)4.11119242
42negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.10668674
43* male meiosis I (GO:0007141)4.09084357
44regulation of DNA methylation (GO:0044030)4.08719529
45regulation of exit from mitosis (GO:0007096)4.06444194
46gene silencing by RNA (GO:0031047)4.03809480
47maturation of 5.8S rRNA (GO:0000460)4.00350904
48resolution of meiotic recombination intermediates (GO:0000712)3.99508270
49protein polyglutamylation (GO:0018095)3.95273553
50* gamete generation (GO:0007276)3.91141847
51rRNA modification (GO:0000154)3.90169774
52DNA damage response, signal transduction resulting in transcription (GO:0042772)3.90100644
53meiotic chromosome segregation (GO:0045132)3.89512815
54cell-cell recognition (GO:0009988)3.88919558
55* spermatogenesis (GO:0007283)3.84937158
56* male gamete generation (GO:0048232)3.84112544
57centriole replication (GO:0007099)3.81007345
58oocyte maturation (GO:0001556)3.80138422
59* meiosis I (GO:0007127)3.78453534
60attachment of spindle microtubules to kinetochore (GO:0008608)3.78314181
61metaphase plate congression (GO:0051310)3.77698117
62protein K6-linked ubiquitination (GO:0085020)3.69865209
63rRNA methylation (GO:0031167)3.66288801
64* meiotic cell cycle process (GO:1903046)3.66263610
65retinal cone cell development (GO:0046549)3.64522166
66regulation of female gonad development (GO:2000194)3.60000548
67negative regulation of inclusion body assembly (GO:0090084)3.58935477
68sister chromatid cohesion (GO:0007062)3.57703386
69DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.57654135
70positive regulation of meiosis (GO:0045836)3.51686766
71cell wall macromolecule catabolic process (GO:0016998)3.46214347
72cell wall macromolecule metabolic process (GO:0044036)3.46214347
73mitotic chromosome condensation (GO:0007076)3.46173957
74mitotic sister chromatid segregation (GO:0000070)3.43158740
75positive regulation of meiotic cell cycle (GO:0051446)3.42721807
76DNA damage induced protein phosphorylation (GO:0006975)3.41177356
77histone exchange (GO:0043486)3.40604536
78establishment of chromosome localization (GO:0051303)3.40429863
79DNA alkylation (GO:0006305)3.39500392
80DNA methylation (GO:0006306)3.39500392
81microtubule polymerization or depolymerization (GO:0031109)3.37255255
82regulation of histone H3-K27 methylation (GO:0061085)3.34443541
83regulation of spindle checkpoint (GO:0090231)3.32225974
84DNA deamination (GO:0045006)3.29944144
85histone H2A monoubiquitination (GO:0035518)3.23555930
86microtubule nucleation (GO:0007020)3.21961250
87somite rostral/caudal axis specification (GO:0032525)3.21106905
88mitotic sister chromatid cohesion (GO:0007064)3.20454022
89single strand break repair (GO:0000012)3.20353603
90female gonad development (GO:0008585)3.19135562
91cellular process involved in reproduction in multicellular organism (GO:0022412)3.19080175
92regulation of acrosome reaction (GO:0060046)3.18495215
93regulation of retinoic acid receptor signaling pathway (GO:0048385)3.15704010
94regulation of glucocorticoid metabolic process (GO:0031943)3.14756757
95germ cell development (GO:0007281)3.13978128
96regulation of RIG-I signaling pathway (GO:0039535)3.13512602
97centriole assembly (GO:0098534)3.11992926
98positive regulation of megakaryocyte differentiation (GO:0045654)3.07280729
99* multicellular organismal reproductive process (GO:0048609)3.04156769
100oogenesis (GO:0048477)3.03715534
101behavioral response to nicotine (GO:0035095)3.02092844
102response to pheromone (GO:0019236)2.99420233
103CENP-A containing nucleosome assembly (GO:0034080)2.97453405
104regulation of chromosome segregation (GO:0051983)2.97330155
105regulation of sister chromatid cohesion (GO:0007063)2.94512708
106chromatin remodeling at centromere (GO:0031055)2.92885681
107gonadal mesoderm development (GO:0007506)2.92318933
108negative regulation of meiotic cell cycle (GO:0051447)2.91767454
109regulation of microtubule-based movement (GO:0060632)2.91409151
110negative regulation of DNA-dependent DNA replication (GO:2000104)2.90700382
111chromosome segregation (GO:0007059)2.90368824
112snRNA transcription (GO:0009301)2.89213638
113sperm capacitation (GO:0048240)2.88936431
114spermatid nucleus differentiation (GO:0007289)2.88631578
115type B pancreatic cell development (GO:0003323)2.87031065
116protein localization to chromosome, centromeric region (GO:0071459)2.86073174
117positive regulation of gastrulation (GO:2000543)2.85602098
118myoblast migration (GO:0051451)2.85379127
119reciprocal meiotic recombination (GO:0007131)2.85050517
120reciprocal DNA recombination (GO:0035825)2.85050517
121protein localization to chromosome (GO:0034502)2.84934529
122positive regulation of prostaglandin secretion (GO:0032308)2.84676093
123cellular response to gamma radiation (GO:0071480)2.81227714
124proteasome assembly (GO:0043248)2.78932384
125seminiferous tubule development (GO:0072520)2.72270031
126DNA methylation or demethylation (GO:0044728)2.69854255
127chromosome condensation (GO:0030261)2.69655866
128protein targeting to Golgi (GO:0000042)2.68914317
129establishment of protein localization to Golgi (GO:0072600)2.67030356
130regulation of histone H3-K9 methylation (GO:0051570)2.66849284
131chaperone-mediated protein transport (GO:0072321)2.65533272
132regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.65039173
133DNA modification (GO:0006304)2.61969734
134RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.55997459
135tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.55997459
136calcium ion-dependent exocytosis (GO:0017156)2.55449111
137DNA packaging (GO:0006323)2.54846301
138protein-cofactor linkage (GO:0018065)2.54822621
139transcription elongation from RNA polymerase III promoter (GO:0006385)2.53679839
140termination of RNA polymerase III transcription (GO:0006386)2.53679839
141L-fucose catabolic process (GO:0042355)2.51807707
142L-fucose metabolic process (GO:0042354)2.51807707

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.78039648
2ZNF274_21170338_ChIP-Seq_K562_Hela4.11471432
3EZH2_22144423_ChIP-Seq_EOC_Human3.74292448
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.31981192
5KAP1_22055183_ChIP-Seq_ESCs_Mouse3.07423619
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.66986187
7* TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.66828199
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.57588908
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.55462161
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.53221265
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.50094890
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.36080405
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.32320006
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.30664878
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.25463714
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.19302110
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.17399971
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.10263238
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.07608520
20* GATA1_26923725_Chip-Seq_HPCs_Mouse2.01264091
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99775852
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.92198943
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.90155893
24FUS_26573619_Chip-Seq_HEK293_Human1.88397753
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88233191
26* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.87063636
27VDR_22108803_ChIP-Seq_LS180_Human1.86771631
28RNF2_27304074_Chip-Seq_NSC_Mouse1.86718071
29MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.81578510
30GBX2_23144817_ChIP-Seq_PC3_Human1.79597655
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79007666
32KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.78265806
33* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.77113876
34TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76032876
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.76032876
36IRF1_19129219_ChIP-ChIP_H3396_Human1.75208138
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.73957412
38NANOG_18555785_Chip-Seq_ESCs_Mouse1.71203138
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.70126386
40TP53_22573176_ChIP-Seq_HFKS_Human1.69976986
41KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.69966193
42KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.69966193
43KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.69966193
44IGF1R_20145208_ChIP-Seq_DFB_Human1.69093108
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.65277976
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58738717
47* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58579151
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.58532180
49* LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55523459
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.54692641
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.54001722
52* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.53816315
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52101671
54ETS1_20019798_ChIP-Seq_JURKAT_Human1.51596632
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.51456589
56MYC_18940864_ChIP-ChIP_HL60_Human1.49911338
57STAT3_23295773_ChIP-Seq_U87_Human1.48797395
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47431401
59CBP_20019798_ChIP-Seq_JUKART_Human1.47431401
60ELK4_26923725_Chip-Seq_MESODERM_Mouse1.46519789
61* RUNX1_26923725_Chip-Seq_HPCs_Mouse1.46109724
62VDR_23849224_ChIP-Seq_CD4+_Human1.45450563
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45065235
64HOXB7_26014856_ChIP-Seq_BT474_Human1.44193971
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.43426813
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.41311188
67TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.41283715
68* STAT1_17558387_ChIP-Seq_HELA_Human1.41208367
69TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.40654683
70GATA3_21878914_ChIP-Seq_MCF-7_Human1.40619351
71* TAL1_26923725_Chip-Seq_HPCs_Mouse1.39418783
72KDM2B_26808549_Chip-Seq_REH_Human1.39284377
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.38241095
74SMAD4_21799915_ChIP-Seq_A2780_Human1.37884996
75EWS_26573619_Chip-Seq_HEK293_Human1.35712031
76* TAF15_26573619_Chip-Seq_HEK293_Human1.35345637
77JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.34449361
78RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.34346506
79NANOG_20526341_ChIP-Seq_ESCs_Human1.34246590
80* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34012872
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.33892664
82* ETV1_20927104_ChIP-Seq_GIST48_Human1.32140021
83NCOR_22424771_ChIP-Seq_293T_Human1.30936677
84FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29793360
85FOXA1_25329375_ChIP-Seq_VCAP_Human1.29793360
86CBX2_27304074_Chip-Seq_ESCs_Mouse1.29623408
87NANOG_19829295_ChIP-Seq_ESCs_Human1.28915147
88SOX2_19829295_ChIP-Seq_ESCs_Human1.28915147
89ERA_21632823_ChIP-Seq_H3396_Human1.26658418
90EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.25917370
91* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.25742111
92* RBPJ_21746931_ChIP-Seq_IB4_Human1.25604999
93CMYC_18555785_Chip-Seq_ESCs_Mouse1.24916345
94CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.24328126
95STAT3_18555785_Chip-Seq_ESCs_Mouse1.22711289
96TCF4_23295773_ChIP-Seq_U87_Human1.22203329
97KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21761819
98MYC_19829295_ChIP-Seq_ESCs_Human1.21342206
99SOX2_18555785_Chip-Seq_ESCs_Mouse1.21196330
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.20828966
101RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20168468
102FOXH1_21741376_ChIP-Seq_EPCs_Human1.20066163
103KLF4_18555785_Chip-Seq_ESCs_Mouse1.19925042
104E2F4_17652178_ChIP-ChIP_JURKAT_Human1.19515610
105CDX2_22108803_ChIP-Seq_LS180_Human1.17032449
106P53_22387025_ChIP-Seq_ESCs_Mouse1.17013334
107* PHF8_20622853_ChIP-Seq_HELA_Human1.16740982
108FLI1_21867929_ChIP-Seq_TH2_Mouse1.16554217
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16104994
110SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16068440
111BCAT_22108803_ChIP-Seq_LS180_Human1.15549014
112FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15080871
113GATA3_21867929_ChIP-Seq_TH1_Mouse1.14891564
114CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14609994
115* NFYB_21822215_ChIP-Seq_K562_Human1.12423081
116REST_21632747_ChIP-Seq_MESCs_Mouse1.12205604
117E2F1_18555785_Chip-Seq_ESCs_Mouse1.11701890
118AR_20517297_ChIP-Seq_VCAP_Human1.11500101
119* TBL1_22424771_ChIP-Seq_293T_Human1.11115221
120CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10789342
121NMYC_18555785_Chip-Seq_ESCs_Mouse1.10458388
122OCT4_18555785_Chip-Seq_ESCs_Mouse1.10324339
123* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10180366
124PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10114960
125RUNX2_22187159_ChIP-Seq_PCA_Human1.09662503
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09357756
127RAC3_21632823_ChIP-Seq_H3396_Human1.09217147
128AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08693201
129ER_23166858_ChIP-Seq_MCF-7_Human1.08447032
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08414388
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08065170
132* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05955070
133SMAD4_21741376_ChIP-Seq_EPCs_Human1.05035991
134STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04817842
135FOXP3_21729870_ChIP-Seq_TREG_Human1.04018749
136ERG_20517297_ChIP-Seq_VCAP_Human1.03962218
137P300_19829295_ChIP-Seq_ESCs_Human1.03821282
138CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.03790937
139OCT4_20526341_ChIP-Seq_ESCs_Human1.03314770
140P300_18555785_Chip-Seq_ESCs_Mouse1.03091102
141TCF4_22108803_ChIP-Seq_LS180_Human1.02919793
142* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.02535676
143ESRRB_18555785_Chip-Seq_ESCs_Mouse1.02002777
144* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.01988601
145FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01701138
146CTCF_18555785_Chip-Seq_ESCs_Mouse1.01637504
147* HNFA_21074721_ChIP-Seq_CACO-2_Human1.00832692
148ZFX_18555785_Chip-Seq_ESCs_Mouse1.00451977
149PRDM14_20953172_ChIP-Seq_ESCs_Human1.00440528
150AR_25329375_ChIP-Seq_VCAP_Human0.99702621
151BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99430502
152CRX_20693478_ChIP-Seq_RETINA_Mouse0.99037690
153WDR5_24793694_ChIP-Seq_LNCAP_Human0.98955845
154VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98938431
155RUNX1_27457419_Chip-Seq_LIVER_Mouse0.98527539
156* GATA6_21074721_ChIP-Seq_CACO-2_Human0.97075042
157FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96990776
158TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96982520
159TAF2_19829295_ChIP-Seq_ESCs_Human0.96727411
160PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95881229
161PIAS1_25552417_ChIP-Seq_VCAP_Human0.95647080

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.69717719
2MP0008877_abnormal_DNA_methylation5.52401675
3MP0002102_abnormal_ear_morphology4.63915186
4MP0002653_abnormal_ependyma_morphology4.52279378
5MP0003646_muscle_fatigue4.27230070
6MP0005451_abnormal_body_composition4.03374466
7* MP0001929_abnormal_gametogenesis3.66560478
8MP0003718_maternal_effect3.25383664
9* MP0003698_abnormal_male_reproductive3.16896070
10MP0002210_abnormal_sex_determination3.09622697
11MP0001986_abnormal_taste_sensitivity2.75515648
12MP0000653_abnormal_sex_gland2.67675425
13MP0003693_abnormal_embryo_hatching2.63637434
14MP0001145_abnormal_male_reproductive2.48959646
15MP0001529_abnormal_vocalization2.32791936
16MP0003136_yellow_coat_color2.28733757
17MP0001984_abnormal_olfaction2.25634799
18* MP0002161_abnormal_fertility/fecundity2.22860945
19MP0005423_abnormal_somatic_nervous2.20536010
20MP0005394_taste/olfaction_phenotype2.07170010
21MP0005499_abnormal_olfactory_system2.07170010
22MP0006292_abnormal_olfactory_placode2.02478973
23MP0002138_abnormal_hepatobiliary_system1.96893064
24MP0010094_abnormal_chromosome_stability1.93821631
25MP0003123_paternal_imprinting1.91560803
26MP0004270_analgesia1.91265715
27MP0003890_abnormal_embryonic-extraembry1.88003447
28MP0005377_hearing/vestibular/ear_phenot1.85528417
29MP0003878_abnormal_ear_physiology1.85528417
30MP0003699_abnormal_female_reproductive1.83187067
31MP0001119_abnormal_female_reproductive1.79708773
32MP0005551_abnormal_eye_electrophysiolog1.76795227
33MP0003111_abnormal_nucleus_morphology1.75664588
34MP0003195_calcinosis1.72141602
35MP0003787_abnormal_imprinting1.68644845
36MP0003880_abnormal_central_pattern1.65414361
37MP0002234_abnormal_pharynx_morphology1.64168102
38MP0003077_abnormal_cell_cycle1.60411388
39MP0005646_abnormal_pituitary_gland1.55379525
40MP0008995_early_reproductive_senescence1.54600247
41MP0005408_hypopigmentation1.53781173
42MP0001905_abnormal_dopamine_level1.46078501
43MP0001293_anophthalmia1.46066984
44MP0005395_other_phenotype1.44320400
45MP0002638_abnormal_pupillary_reflex1.43391174
46MP0000462_abnormal_digestive_system1.42425568
47MP0003937_abnormal_limbs/digits/tail_de1.39845506
48MP0004142_abnormal_muscle_tone1.34882148
49MP0004885_abnormal_endolymph1.34858423
50MP0008057_abnormal_DNA_replication1.34559055
51MP0002249_abnormal_larynx_morphology1.32244546
52MP0004957_abnormal_blastocyst_morpholog1.30091845
53MP0002160_abnormal_reproductive_system1.29781217
54MP0004185_abnormal_adipocyte_glucose1.23045402
55MP0002734_abnormal_mechanical_nocicepti1.22794217
56MP0002277_abnormal_respiratory_mucosa1.22038418
57MP0005253_abnormal_eye_physiology1.20883255
58MP0008872_abnormal_physiological_respon1.20125394
59MP0002735_abnormal_chemical_nociception1.19290293
60MP0003119_abnormal_digestive_system1.17478237
61MP0002837_dystrophic_cardiac_calcinosis1.16938248
62MP0004859_abnormal_synaptic_plasticity1.16614709
63MP0005085_abnormal_gallbladder_physiolo1.09930263
64MP0008875_abnormal_xenobiotic_pharmacok1.09684750
65MP0005310_abnormal_salivary_gland1.09223824
66MP0009379_abnormal_foot_pigmentation1.08354964
67MP0003121_genomic_imprinting1.07069085
68MP0002127_abnormal_cardiovascular_syste1.05367854
69MP0004145_abnormal_muscle_electrophysio1.04424916
70MP0005360_urolithiasis1.03317390
71MP0003011_delayed_dark_adaptation1.01705309
72MP0008007_abnormal_cellular_replicative1.01306829
73MP0000639_abnormal_adrenal_gland1.00605676
74MP0000579_abnormal_nail_morphology0.98681446
75MP0003635_abnormal_synaptic_transmissio0.97428922
76MP0005174_abnormal_tail_pigmentation0.97343662
77MP0000049_abnormal_middle_ear0.96522953
78MP0008058_abnormal_DNA_repair0.96316743
79MP0000372_irregular_coat_pigmentation0.95947168
80MP0009745_abnormal_behavioral_response0.94860884
81MP0003329_amyloid_beta_deposits0.94318081
82MP0001502_abnormal_circadian_rhythm0.92048435
83MP0010386_abnormal_urinary_bladder0.91096378
84MP0005084_abnormal_gallbladder_morpholo0.90583068
85MP0010307_abnormal_tumor_latency0.90338572
86MP0008932_abnormal_embryonic_tissue0.89938160
87MP0002085_abnormal_embryonic_tissue0.88657913
88MP0005647_abnormal_sex_gland0.88600428
89MP0001851_eye_inflammation0.87837673
90MP0005379_endocrine/exocrine_gland_phen0.85965068
91MP0003861_abnormal_nervous_system0.85241737
92MP0003315_abnormal_perineum_morphology0.85064792
93MP0004147_increased_porphyrin_level0.84867149
94MP0002184_abnormal_innervation0.84522082
95MP0001919_abnormal_reproductive_system0.83893510
96MP0005389_reproductive_system_phenotype0.83731396
97MP0001188_hyperpigmentation0.83506812
98MP0006276_abnormal_autonomic_nervous0.83283928
99MP0002736_abnormal_nociception_after0.82633668
100MP0002876_abnormal_thyroid_physiology0.82608385
101MP0000569_abnormal_digit_pigmentation0.82410502
102MP0004742_abnormal_vestibular_system0.82135664
103MP0002063_abnormal_learning/memory/cond0.81318691
104MP0002928_abnormal_bile_duct0.81177569
105MP0003786_premature_aging0.81008440
106MP0003879_abnormal_hair_cell0.80877190
107MP0000026_abnormal_inner_ear0.80760685
108MP0009046_muscle_twitch0.80519549
109MP0009250_abnormal_appendicular_skeleto0.80268344
110MP0001730_embryonic_growth_arrest0.79343332
111MP0005075_abnormal_melanosome_morpholog0.79135592
112MP0002139_abnormal_hepatobiliary_system0.79024507
113MP0003567_abnormal_fetal_cardiomyocyte0.78912714
114MP0000778_abnormal_nervous_system0.78836533
115MP0001486_abnormal_startle_reflex0.78822956
116MP0000631_abnormal_neuroendocrine_gland0.78115975
117MP0000427_abnormal_hair_cycle0.76739463
118MP0002095_abnormal_skin_pigmentation0.76185401
119MP0000647_abnormal_sebaceous_gland0.75533411
120MP0003950_abnormal_plasma_membrane0.74897351
121MP0002084_abnormal_developmental_patter0.74616201
122MP0002572_abnormal_emotion/affect_behav0.74506186
123MP0004233_abnormal_muscle_weight0.73540546
124MP0001697_abnormal_embryo_size0.72805215
125MP0005195_abnormal_posterior_eye0.72477347
126MP0002752_abnormal_somatic_nervous0.72473020
127MP0001324_abnormal_eye_pigmentation0.72070928
128MP0003936_abnormal_reproductive_system0.70695778
129MP0006036_abnormal_mitochondrial_physio0.70641696
130MP0010030_abnormal_orbit_morphology0.69935645
131MP0003755_abnormal_palate_morphology0.68579812
132MP0003632_abnormal_nervous_system0.67701695
133MP0002152_abnormal_brain_morphology0.67042934
134MP0002272_abnormal_nervous_system0.66851427
135MP0002233_abnormal_nose_morphology0.66479422
136MP0001485_abnormal_pinna_reflex0.65963110
137MP0005386_behavior/neurological_phenoty0.65474777
138MP0004924_abnormal_behavior0.65474777
139MP0000566_synostosis0.63833523
140MP0001968_abnormal_touch/_nociception0.60058485
141MP0002882_abnormal_neuron_morphology0.59409541
142MP0008789_abnormal_olfactory_epithelium0.57597813
143MP0001963_abnormal_hearing_physiology0.56655265
144MP0002116_abnormal_craniofacial_bone0.55541091
145MP0006072_abnormal_retinal_apoptosis0.55350740
146MP0000350_abnormal_cell_proliferation0.54555107
147MP0001440_abnormal_grooming_behavior0.54510119
148MP0003938_abnormal_ear_development0.54286471
149MP0001915_intracranial_hemorrhage0.52715708
150MP0008260_abnormal_autophagy0.51115746
151MP0001672_abnormal_embryogenesis/_devel0.50934765
152MP0005380_embryogenesis_phenotype0.50934765
153MP0000955_abnormal_spinal_cord0.50581989

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.89658046
2Abnormal respiratory motile cilium physiology (HP:0012261)6.62296389
3Male infertility (HP:0003251)6.58094524
4Absent/shortened dynein arms (HP:0200106)6.42809425
5Dynein arm defect of respiratory motile cilia (HP:0012255)6.42809425
6Rhinitis (HP:0012384)5.59672260
7Chronic bronchitis (HP:0004469)5.31731186
8Infertility (HP:0000789)4.98137719
9Abnormal ciliary motility (HP:0012262)4.87276857
10Abnormal respiratory motile cilium morphology (HP:0005938)4.65270169
11Abnormal respiratory epithelium morphology (HP:0012253)4.65270169
12Papillary thyroid carcinoma (HP:0002895)3.77941222
13Nephronophthisis (HP:0000090)3.53260078
14Facial hemangioma (HP:0000329)3.36066875
15Molar tooth sign on MRI (HP:0002419)3.25751879
16Abnormality of midbrain morphology (HP:0002418)3.25751879
17Pancreatic fibrosis (HP:0100732)3.25345908
18Bronchiectasis (HP:0002110)3.18650781
19Abnormal spermatogenesis (HP:0008669)3.11044079
20Pendular nystagmus (HP:0012043)3.04492146
21Azoospermia (HP:0000027)3.03165008
22Attenuation of retinal blood vessels (HP:0007843)2.99297937
23Chronic hepatic failure (HP:0100626)2.98972939
24Type II lissencephaly (HP:0007260)2.92262342
25Adrenal hypoplasia (HP:0000835)2.90020208
26Birth length less than 3rd percentile (HP:0003561)2.85843849
27Breast hypoplasia (HP:0003187)2.78174805
28Abnormality of the renal medulla (HP:0100957)2.75353714
29Microglossia (HP:0000171)2.72672292
30Medial flaring of the eyebrow (HP:0010747)2.72085864
31Hypophosphatemic rickets (HP:0004912)2.71954365
32Supernumerary spleens (HP:0009799)2.71953415
33Capillary hemangiomas (HP:0005306)2.70897173
34Abnormal rod and cone electroretinograms (HP:0008323)2.65345349
35Abnormality of the labia minora (HP:0012880)2.64367123
36Congenital stationary night blindness (HP:0007642)2.57686656
37Oligodactyly (hands) (HP:0001180)2.57529522
38Nasal polyposis (HP:0100582)2.57273284
39Chromsome breakage (HP:0040012)2.56975804
40Osteomalacia (HP:0002749)2.56858758
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.56163734
42Abnormality of alanine metabolism (HP:0010916)2.56163734
43Hyperalaninemia (HP:0003348)2.56163734
44Aplasia/Hypoplasia of the fovea (HP:0008060)2.52698929
45Hypoplasia of the fovea (HP:0007750)2.52698929
46Pancreatic cysts (HP:0001737)2.52225879
47Decreased central vision (HP:0007663)2.50566304
48Abdominal situs inversus (HP:0003363)2.50553259
49Abnormality of abdominal situs (HP:0011620)2.50553259
50Polydipsia (HP:0001959)2.47586731
51Abnormal drinking behavior (HP:0030082)2.47586731
52Absent rod-and cone-mediated responses on ERG (HP:0007688)2.47311953
53Abnormality of the ileum (HP:0001549)2.46827188
54Chromosomal breakage induced by crosslinking agents (HP:0003221)2.44456086
55Aplasia/hypoplasia of the uterus (HP:0008684)2.44414126
56Gait imbalance (HP:0002141)2.43286699
57Poor coordination (HP:0002370)2.41006195
58Shawl scrotum (HP:0000049)2.36408893
59Congenital primary aphakia (HP:0007707)2.35728055
60Aplasia/Hypoplasia of the tibia (HP:0005772)2.34846054
61Cerebellar dysplasia (HP:0007033)2.32803871
62Aplasia/Hypoplasia of the tongue (HP:0010295)2.31586544
63Glycosuria (HP:0003076)2.30136239
64Abnormality of urine glucose concentration (HP:0011016)2.30136239
65Bronchitis (HP:0012387)2.30036125
66Short tibia (HP:0005736)2.27467396
67Breast aplasia (HP:0100783)2.26412579
68Patellar aplasia (HP:0006443)2.22423556
69Aplasia/Hypoplasia of the breasts (HP:0010311)2.22393331
70Oligodactyly (HP:0012165)2.21769771
71Abnormality of the phalanges of the hallux (HP:0010057)2.21290989
72Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.19915002
73Renal Fanconi syndrome (HP:0001994)2.19797837
74Genital tract atresia (HP:0001827)2.18560893
75Impulsivity (HP:0100710)2.16584872
76Abnormality of the renal collecting system (HP:0004742)2.16537170
77True hermaphroditism (HP:0010459)2.10806812
78Bony spicule pigmentary retinopathy (HP:0007737)2.10057944
79Abnormality of the fovea (HP:0000493)2.09359001
80Hypoplasia of the uterus (HP:0000013)2.08068650
81Flat capital femoral epiphysis (HP:0003370)2.07598692
82Tubular atrophy (HP:0000092)2.05963924
83Aplasia/Hypoplasia of the patella (HP:0006498)2.05772000
84Nephrogenic diabetes insipidus (HP:0009806)2.05691856
85Aplasia/Hypoplasia involving the musculature (HP:0001460)2.04936398
86Absent thumb (HP:0009777)2.04520024
87Vaginal atresia (HP:0000148)2.03630173
88Thyroid carcinoma (HP:0002890)2.02553965
89Secondary amenorrhea (HP:0000869)2.01920652
90Abnormality of the renal cortex (HP:0011035)2.01607160
91Increased CSF lactate (HP:0002490)2.00379187
92Focal motor seizures (HP:0011153)1.99457666
93Amelogenesis imperfecta (HP:0000705)1.99185974
94Acute necrotizing encephalopathy (HP:0006965)1.97555261
95Generalized aminoaciduria (HP:0002909)1.95566107
96Postaxial foot polydactyly (HP:0001830)1.95165228
97Severe visual impairment (HP:0001141)1.94353147
98Primary amenorrhea (HP:0000786)1.94168125
99Median cleft lip (HP:0000161)1.94159155
100Atonic seizures (HP:0010819)1.93389640
101Abnormality of lateral ventricle (HP:0030047)1.93317284
102Duplicated collecting system (HP:0000081)1.92025508
103Carpal bone hypoplasia (HP:0001498)1.91876255
104Absent radius (HP:0003974)1.91444806
105Horseshoe kidney (HP:0000085)1.91433874
106Cystic liver disease (HP:0006706)1.91334347
107Septo-optic dysplasia (HP:0100842)1.90739470
108Recurrent otitis media (HP:0000403)1.90073173
109Congenital malformation of the right heart (HP:0011723)1.88279420
110Double outlet right ventricle (HP:0001719)1.88279420
111Sclerocornea (HP:0000647)1.87144546
112Polyuria (HP:0000103)1.86603889
113Tetany (HP:0001281)1.86293340
114Optic nerve hypoplasia (HP:0000609)1.85624634
115Bifid tongue (HP:0010297)1.85066921
116Aplasia involving forearm bones (HP:0009822)1.84919019
117Absent forearm bone (HP:0003953)1.84919019
118Nonprogressive disorder (HP:0003680)1.84603017
119Postaxial hand polydactyly (HP:0001162)1.84231324
120Hypomagnesemia (HP:0002917)1.83857688
121Gonadotropin excess (HP:0000837)1.82425609
122Inability to walk (HP:0002540)1.82387103
123Concave nail (HP:0001598)1.82181642
124Duodenal stenosis (HP:0100867)1.82066455
125Small intestinal stenosis (HP:0012848)1.82066455
126Spontaneous abortion (HP:0005268)1.81791479
127Absent septum pellucidum (HP:0001331)1.81070861
128Neurofibrillary tangles (HP:0002185)1.81035418
129Stenosis of the external auditory canal (HP:0000402)1.80382883
130Arterial tortuosity (HP:0005116)1.80251078
131Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79376462
132Degeneration of the lateral corticospinal tracts (HP:0002314)1.79376462
133Increased hepatocellular lipid droplets (HP:0006565)1.78466674
134Mitochondrial inheritance (HP:0001427)1.78355462
135Ectopic kidney (HP:0000086)1.78258328
136Aplasia/Hypoplasia of the lens (HP:0008063)1.78103973
137Abnormality of the nasal mucosa (HP:0000433)1.76774750
138Tubulointerstitial nephritis (HP:0001970)1.76610082
139Abnormality of the fingertips (HP:0001211)1.76377201
140Aplasia/Hypoplasia of the uvula (HP:0010293)1.74247820
141Abnormality of chromosome stability (HP:0003220)1.73939649
142Abnormality of the epiphysis of the femoral head (HP:0010574)1.72752875
143Amyotrophic lateral sclerosis (HP:0007354)1.70893187
144Sandal gap (HP:0001852)1.70680662
145Occipital encephalocele (HP:0002085)1.70280874
146Abnormality of the corticospinal tract (HP:0002492)1.67998288
147Midline defect of the nose (HP:0004122)1.67308720
148Hypoplasia of the capital femoral epiphysis (HP:0003090)1.65841874
149Male pseudohermaphroditism (HP:0000037)1.65758841
150Acute myeloid leukemia (HP:0004808)1.64984593
151Abnormality of chromosome segregation (HP:0002916)1.63612959
152Anterior segment dysgenesis (HP:0007700)1.62367946
153Abnormality of the femoral head (HP:0003368)1.61980104
154Aganglionic megacolon (HP:0002251)1.61975096
155Sloping forehead (HP:0000340)1.60479792
156Peripheral hypomyelination (HP:0007182)1.60302474
157Abnormality of the preputium (HP:0100587)1.58035474
158Tubulointerstitial abnormality (HP:0001969)1.57544610
159Cystic hygroma (HP:0000476)1.56946071
160Oculomotor apraxia (HP:0000657)1.55477491
161Meckel diverticulum (HP:0002245)1.54598079
162Retinal dysplasia (HP:0007973)1.53294532
163Heterotopia (HP:0002282)1.52983399
164Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.52920008
165Abnormality of femoral epiphyses (HP:0006499)1.52920008

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK3.46077087
2KSR23.34617553
3MAP3K63.29037086
4LATS23.21801241
5LATS13.17389015
6ZAK3.05042928
7PLK42.97932772
8MAP3K92.87493597
9STK38L2.86321230
10PDK32.81895915
11PDK42.81895915
12ERBB42.77643793
13PRKD32.67575534
14BRAF2.51335759
15ARAF2.42531806
16TLK12.28838939
17MAP3K132.28278604
18RAF12.21950627
19CDC72.20860619
20PBK2.12279459
21TAOK12.07884831
22TTK2.06431729
23INSRR1.99529739
24EEF2K1.99352937
25CDK191.93590188
26PAK61.89067261
27TXK1.88213639
28FRK1.87831956
29STK161.82047174
30ADRBK21.81853593
31MAP4K21.68142307
32NEK21.66225011
33KSR11.64807287
34MAP3K41.51201115
35STK31.49549620
36PDK21.47113383
37TAOK31.47036658
38SRPK11.47026770
39MOS1.43015023
40GRK11.42931095
41DYRK21.40390818
42CDK91.38002832
43STK391.36755054
44CHEK21.35356965
45STK381.33632004
46TYRO31.31842237
47WEE11.28355218
48WNK31.26433715
49MAPKAPK51.24775118
50CDK81.23655398
51MAPK131.18019203
52MELK1.14315937
53MAP2K71.12780475
54VRK11.09616160
55TRIM281.05435355
56MAPKAPK31.05227629
57CDK31.02200302
58TIE11.01743406
59NEK60.97925196
60IRAK10.93977555
61WNK10.93858262
62PLK10.92296579
63MST40.92031019
64PRKD20.91121470
65PRKCI0.87894922
66MARK20.87120242
67TSSK60.83104093
68EPHA40.82991782
69ICK0.82929978
70ABL20.82840530
71EIF2AK30.80085032
72BCKDK0.77923763
73ACVR1B0.77237899
74NTRK20.76507369
75CSNK1G20.75548963
76CSNK1G10.73546091
77TESK20.72477802
78PNCK0.72057887
79BMPR20.71862728
80AKT30.71119109
81DAPK20.70818033
82PTK2B0.70416032
83CAMK2A0.67888386
84PRKCG0.66464443
85DMPK0.66462794
86CAMK1G0.66199514
87MAP2K40.65867105
88WNK40.65489096
89ADRBK10.65329631
90NUAK10.62837069
91BMPR1B0.62446838
92PKN10.62204280
93CSNK1G30.60224692
94GRK70.59904929
95BRSK20.58781970
96CHEK10.56409338
97BRSK10.55589904
98PIM10.55395788
99PRKAA10.54753318
100OXSR10.54126356
101STK240.53066769
102CDK70.52351804
103CAMKK20.51707654
104ATR0.50573801
105PLK30.50124418
106PRKAA20.49004952
107PRKCQ0.48876903
108MARK30.48511766
109VRK20.48212725
110MKNK20.48034744
111ATM0.47625552
112PRKG10.47088721
113CSNK1A1L0.46680706
114PIK3CG0.46497062
115MAPK150.45860705
116TGFBR10.45390208
117PRKCE0.44400542
118NTRK30.44327749
119TNIK0.43997185
120SGK2230.43238602
121SGK4940.43238602
122AURKA0.41800995
123CDK150.41779369
124NME10.41039331
125PLK20.40801243
126CDK180.38539036
127PRKACA0.38371449
128CCNB10.38060696
129PAK30.37965450
130NLK0.36215130
131AURKB0.36160295
132MAP3K50.36122147
133FGR0.36077534
134DYRK30.35698043
135CSNK2A10.34875735
136SGK20.34628964
137CDK11A0.33597323
138PINK10.33525690
139PDK10.32641551
140STK110.32581794
141CDK120.30880405
142RET0.30580016
143CSNK1E0.30454822
144MAP3K10.29973604
145CAMK10.29869822
146TRPM70.27262630
147BUB10.26981730
148MAPK100.26832724
149PDPK10.26773985
150DYRK1A0.26562018
151CDK140.25779834
152CDK10.25198604
153PAK10.23513615
154MAP3K80.22062898

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.50877251
2Basal transcription factors_Homo sapiens_hsa030224.01235515
3Cell cycle_Homo sapiens_hsa041103.27113427
4RNA degradation_Homo sapiens_hsa030182.72523166
5Oocyte meiosis_Homo sapiens_hsa041142.71173005
6Phototransduction_Homo sapiens_hsa047442.68673594
7Linoleic acid metabolism_Homo sapiens_hsa005912.54005104
8Dorso-ventral axis formation_Homo sapiens_hsa043202.53691162
9Ovarian steroidogenesis_Homo sapiens_hsa049132.50069522
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.47563190
11Ether lipid metabolism_Homo sapiens_hsa005652.46059246
12Circadian rhythm_Homo sapiens_hsa047102.40457447
13Ribosome_Homo sapiens_hsa030102.25990990
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.24912224
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.24211015
16Oxidative phosphorylation_Homo sapiens_hsa001902.14505368
17Fanconi anemia pathway_Homo sapiens_hsa034602.12462475
18Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.07512942
19Caffeine metabolism_Homo sapiens_hsa002321.99628027
20Regulation of autophagy_Homo sapiens_hsa041401.92324925
21Mismatch repair_Homo sapiens_hsa034301.90777129
22Parkinsons disease_Homo sapiens_hsa050121.84145755
23RNA polymerase_Homo sapiens_hsa030201.82293483
24Olfactory transduction_Homo sapiens_hsa047401.71490206
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.66291139
26Butanoate metabolism_Homo sapiens_hsa006501.54167985
27TGF-beta signaling pathway_Homo sapiens_hsa043501.51708042
28Nitrogen metabolism_Homo sapiens_hsa009101.50424219
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.47664810
30Pancreatic cancer_Homo sapiens_hsa052121.46059515
31Protein export_Homo sapiens_hsa030601.44635703
32Homologous recombination_Homo sapiens_hsa034401.44102830
33Cardiac muscle contraction_Homo sapiens_hsa042601.43730279
34GnRH signaling pathway_Homo sapiens_hsa049121.43071940
35RNA transport_Homo sapiens_hsa030131.41735791
36Glutamatergic synapse_Homo sapiens_hsa047241.38711133
37Choline metabolism in cancer_Homo sapiens_hsa052311.37796763
38Glycerophospholipid metabolism_Homo sapiens_hsa005641.35767580
39Selenocompound metabolism_Homo sapiens_hsa004501.34949476
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33961600
41Nicotine addiction_Homo sapiens_hsa050331.31772634
42Folate biosynthesis_Homo sapiens_hsa007901.31668736
43Long-term potentiation_Homo sapiens_hsa047201.31337639
44Amphetamine addiction_Homo sapiens_hsa050311.29403362
45mRNA surveillance pathway_Homo sapiens_hsa030151.23111134
46Renal cell carcinoma_Homo sapiens_hsa052111.23014864
47Long-term depression_Homo sapiens_hsa047301.21057606
48Base excision repair_Homo sapiens_hsa034101.11769258
49p53 signaling pathway_Homo sapiens_hsa041151.08442781
50Serotonergic synapse_Homo sapiens_hsa047261.07530925
51Proteasome_Homo sapiens_hsa030501.06841478
52DNA replication_Homo sapiens_hsa030301.06602857
53VEGF signaling pathway_Homo sapiens_hsa043701.02816489
54Collecting duct acid secretion_Homo sapiens_hsa049661.02583509
55Tryptophan metabolism_Homo sapiens_hsa003801.02252610
56Estrogen signaling pathway_Homo sapiens_hsa049151.01667897
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01432608
58Propanoate metabolism_Homo sapiens_hsa006401.00066923
59ABC transporters_Homo sapiens_hsa020100.97519543
60Glucagon signaling pathway_Homo sapiens_hsa049220.96287096
61Fatty acid biosynthesis_Homo sapiens_hsa000610.94980669
62Purine metabolism_Homo sapiens_hsa002300.91168833
63Dopaminergic synapse_Homo sapiens_hsa047280.90841196
64Prolactin signaling pathway_Homo sapiens_hsa049170.90836696
65cAMP signaling pathway_Homo sapiens_hsa040240.89115266
66Colorectal cancer_Homo sapiens_hsa052100.87478635
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.87135428
68Pyruvate metabolism_Homo sapiens_hsa006200.85038826
69Cocaine addiction_Homo sapiens_hsa050300.83973814
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82908292
71Ras signaling pathway_Homo sapiens_hsa040140.81481008
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.80768585
73Alzheimers disease_Homo sapiens_hsa050100.79351669
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.78559771
75Sphingolipid metabolism_Homo sapiens_hsa006000.75310392
76Synaptic vesicle cycle_Homo sapiens_hsa047210.74582990
77Spliceosome_Homo sapiens_hsa030400.74361185
78One carbon pool by folate_Homo sapiens_hsa006700.74064386
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73969266
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73216556
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73022178
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.72259971
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72030127
84ErbB signaling pathway_Homo sapiens_hsa040120.71694587
85Retinol metabolism_Homo sapiens_hsa008300.71404881
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.69136969
87Peroxisome_Homo sapiens_hsa041460.69123738
88Non-homologous end-joining_Homo sapiens_hsa034500.67444683
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66689285
90Oxytocin signaling pathway_Homo sapiens_hsa049210.66481823
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65975373
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63863623
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63419034
94Arachidonic acid metabolism_Homo sapiens_hsa005900.62510734
95MAPK signaling pathway_Homo sapiens_hsa040100.62306076
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62093071
97Nucleotide excision repair_Homo sapiens_hsa034200.62028332
98Taste transduction_Homo sapiens_hsa047420.61989989
99Metabolic pathways_Homo sapiens_hsa011000.61138114
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61105239
101Sulfur metabolism_Homo sapiens_hsa009200.61100486
102Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61054700
103Circadian entrainment_Homo sapiens_hsa047130.60994419
104Inositol phosphate metabolism_Homo sapiens_hsa005620.60611611
105Chemical carcinogenesis_Homo sapiens_hsa052040.60462154
106Huntingtons disease_Homo sapiens_hsa050160.60351384
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60093703
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59162670
109Morphine addiction_Homo sapiens_hsa050320.59153534
110MicroRNAs in cancer_Homo sapiens_hsa052060.57822106
111FoxO signaling pathway_Homo sapiens_hsa040680.57271209
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56815071
113Insulin secretion_Homo sapiens_hsa049110.56273121
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55738236
115Fatty acid elongation_Homo sapiens_hsa000620.54014389
116Prostate cancer_Homo sapiens_hsa052150.53690100
117Hippo signaling pathway_Homo sapiens_hsa043900.53311340
118Cholinergic synapse_Homo sapiens_hsa047250.52650292
119Endometrial cancer_Homo sapiens_hsa052130.51973449
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50624600
121beta-Alanine metabolism_Homo sapiens_hsa004100.49929134
122Fat digestion and absorption_Homo sapiens_hsa049750.49502825
123Wnt signaling pathway_Homo sapiens_hsa043100.49378282
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.47972481
125Hedgehog signaling pathway_Homo sapiens_hsa043400.47647506
126Glycerolipid metabolism_Homo sapiens_hsa005610.47051572
127Salivary secretion_Homo sapiens_hsa049700.46472523
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46284491
129SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45955667
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45560826
131Pyrimidine metabolism_Homo sapiens_hsa002400.44054362
132Calcium signaling pathway_Homo sapiens_hsa040200.42741290
133Arginine and proline metabolism_Homo sapiens_hsa003300.42665070
134Renin secretion_Homo sapiens_hsa049240.42109244
135Glioma_Homo sapiens_hsa052140.41816360
136Steroid biosynthesis_Homo sapiens_hsa001000.37952584
137Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37457012
138Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36722835
139Gap junction_Homo sapiens_hsa045400.36429414
140Adherens junction_Homo sapiens_hsa045200.35945396
141Tight junction_Homo sapiens_hsa045300.34120138
142Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34089445
143Vitamin digestion and absorption_Homo sapiens_hsa049770.33418282
144GABAergic synapse_Homo sapiens_hsa047270.33267488
145Primary bile acid biosynthesis_Homo sapiens_hsa001200.33250717
146Histidine metabolism_Homo sapiens_hsa003400.33092295
147Melanogenesis_Homo sapiens_hsa049160.33081708
148Pentose phosphate pathway_Homo sapiens_hsa000300.32042890
149Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31990686
150Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30988163
151Drug metabolism - other enzymes_Homo sapiens_hsa009830.30228650
152Bile secretion_Homo sapiens_hsa049760.28982852
153Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28171339
154Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26119543
155Sulfur relay system_Homo sapiens_hsa041220.25720921
156Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24630850

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