BRE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.43275132
2glucocorticoid biosynthetic process (GO:0006704)4.94749495
3protein complex biogenesis (GO:0070271)4.52769065
4proteasome assembly (GO:0043248)4.51354228
5L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.47976935
6signal peptide processing (GO:0006465)4.45565221
7mitochondrial respiratory chain complex I assembly (GO:0032981)4.28286768
8NADH dehydrogenase complex assembly (GO:0010257)4.28286768
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.28286768
10mitochondrial respiratory chain complex assembly (GO:0033108)4.14498869
11purine nucleotide salvage (GO:0032261)4.08015110
12respiratory chain complex IV assembly (GO:0008535)4.07036102
13cytidine deamination (GO:0009972)4.03489857
14cytidine metabolic process (GO:0046087)4.03489857
15cytidine catabolic process (GO:0006216)4.03489857
16cytochrome complex assembly (GO:0017004)3.95890782
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.93246986
18branched-chain amino acid catabolic process (GO:0009083)3.88802139
19oxidative phosphorylation (GO:0006119)3.87209646
20chaperone-mediated protein transport (GO:0072321)3.82277606
21DNA deamination (GO:0045006)3.79680824
22negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.78694961
23antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.77474154
24deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.71382171
25telomere maintenance via semi-conservative replication (GO:0032201)3.66909098
26xenobiotic catabolic process (GO:0042178)3.66344258
27DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.63519076
28GDP-mannose metabolic process (GO:0019673)3.60047131
29signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.59050696
30intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.59050696
31cullin deneddylation (GO:0010388)3.58127139
32protein deneddylation (GO:0000338)3.56782636
33signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.54748383
34signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.54748383
35signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.54748383
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.54138074
37regulation of cellular amino acid metabolic process (GO:0006521)3.52241927
38negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.45559439
39negative regulation of ligase activity (GO:0051352)3.45559439
40positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.45228257
41regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.41057529
42amino acid salvage (GO:0043102)3.39783414
43L-methionine salvage (GO:0071267)3.39783414
44L-methionine biosynthetic process (GO:0071265)3.39783414
45signal transduction involved in DNA integrity checkpoint (GO:0072401)3.39292685
46signal transduction involved in DNA damage checkpoint (GO:0072422)3.39292685
47telomere maintenance via recombination (GO:0000722)3.38119934
48regulation of mitochondrial translation (GO:0070129)3.35958519
49signal transduction involved in cell cycle checkpoint (GO:0072395)3.33251204
50aerobic respiration (GO:0009060)3.30589716
51DNA strand elongation involved in DNA replication (GO:0006271)3.29787880
52pyrimidine ribonucleoside catabolic process (GO:0046133)3.29105135
53regulation of metalloenzyme activity (GO:0048552)3.28759862
54glucocorticoid metabolic process (GO:0008211)3.28188990
55valine metabolic process (GO:0006573)3.28120662
56neutrophil activation involved in immune response (GO:0002283)3.26526592
57branched-chain amino acid metabolic process (GO:0009081)3.26139223
58ATP synthesis coupled proton transport (GO:0015986)3.25335247
59energy coupled proton transport, down electrochemical gradient (GO:0015985)3.25335247
60DNA strand elongation (GO:0022616)3.21375232
61antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.18604266
62C21-steroid hormone biosynthetic process (GO:0006700)3.16644413
63metallo-sulfur cluster assembly (GO:0031163)3.12176349
64iron-sulfur cluster assembly (GO:0016226)3.12176349
65peroxisome fission (GO:0016559)3.11241465
66anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.10628289
67nucleotide-excision repair, DNA gap filling (GO:0006297)3.09639065
68lactate metabolic process (GO:0006089)3.06331144
69regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.02215430
70purine nucleobase biosynthetic process (GO:0009113)3.02181594
71purine-containing compound salvage (GO:0043101)2.99826059
72nucleobase biosynthetic process (GO:0046112)2.99824922
73SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.96882339
74cotranslational protein targeting to membrane (GO:0006613)2.96615298
75mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.95747790
76androgen biosynthetic process (GO:0006702)2.93626154
77oxaloacetate metabolic process (GO:0006107)2.92338137
78ubiquinone biosynthetic process (GO:0006744)2.90374470
79positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.89012645
807-methylguanosine mRNA capping (GO:0006370)2.88661951
81protein targeting to ER (GO:0045047)2.87712810
82positive regulation of ligase activity (GO:0051351)2.87079332
83protein localization to endoplasmic reticulum (GO:0070972)2.86879287
84mitotic recombination (GO:0006312)2.86662037
85protein targeting to mitochondrion (GO:0006626)2.84907254
86respiratory electron transport chain (GO:0022904)2.84882703
87COPI coating of Golgi vesicle (GO:0048205)2.83205442
88Golgi transport vesicle coating (GO:0048200)2.83205442
89formation of translation preinitiation complex (GO:0001731)2.82837798
90termination of RNA polymerase III transcription (GO:0006386)2.82611900
91transcription elongation from RNA polymerase III promoter (GO:0006385)2.82611900
92pentose metabolic process (GO:0019321)2.82450423
93NADH metabolic process (GO:0006734)2.81727279
94transcription-coupled nucleotide-excision repair (GO:0006283)2.81384166
95DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.80583672
96RNA capping (GO:0036260)2.80346008
977-methylguanosine RNA capping (GO:0009452)2.80346008
98negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.80190419
99electron transport chain (GO:0022900)2.79602867
100mannosylation (GO:0097502)2.78957975
101pseudouridine synthesis (GO:0001522)2.77869767
102progesterone metabolic process (GO:0042448)2.75227413
103positive regulation of defense response to virus by host (GO:0002230)2.74792948
104adenosine metabolic process (GO:0046085)2.74728353
105response to interferon-beta (GO:0035456)2.74319843
106platelet dense granule organization (GO:0060155)2.73542348
107galactose metabolic process (GO:0006012)2.73214282
108cellular response to antibiotic (GO:0071236)2.71441021
109viral protein processing (GO:0019082)2.70724764
110positive regulation of cell cycle arrest (GO:0071158)2.70715199
111water-soluble vitamin biosynthetic process (GO:0042364)2.70542309
112establishment of protein localization to endoplasmic reticulum (GO:0072599)2.70190695
113telomere maintenance via telomere lengthening (GO:0010833)2.69193110
114sequestering of actin monomers (GO:0042989)2.69033557
115protein neddylation (GO:0045116)2.68609613
116translation (GO:0006412)2.68577092
117viral mRNA export from host cell nucleus (GO:0046784)2.67837339
118establishment of protein localization to mitochondrion (GO:0072655)2.65812723
119negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.65702696
120ketone biosynthetic process (GO:0042181)2.65435971
121de novo protein folding (GO:0006458)2.65421636
122energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.65271259
123ATP hydrolysis coupled proton transport (GO:0015991)2.65271259
124de novo posttranslational protein folding (GO:0051084)2.64878512
125regulation of cellular amine metabolic process (GO:0033238)2.64301894
126deoxyribose phosphate biosynthetic process (GO:0046385)2.63215549
1272-deoxyribonucleotide biosynthetic process (GO:0009265)2.63215549
128positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.62600215
129methionine biosynthetic process (GO:0009086)2.60946448
130establishment of protein localization to mitochondrial membrane (GO:0090151)2.60274228
131peptidyl-histidine modification (GO:0018202)2.59518297
132tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.57042659
133RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.57042659
134C21-steroid hormone metabolic process (GO:0008207)2.54935440
135negative regulation of neurological system process (GO:0031645)2.54852700
136nucleotide salvage (GO:0043173)2.54681861
137regulation of chronic inflammatory response (GO:0002676)2.52224091
138cellular response to zinc ion (GO:0071294)2.48440204
139regulation of regulatory T cell differentiation (GO:0045589)2.47525638
140erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.46951450
141L-phenylalanine catabolic process (GO:0006559)2.46951450
142pyrimidine nucleoside catabolic process (GO:0046135)2.46663445
143positive regulation of amino acid transport (GO:0051957)2.45933204
144purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.43984754
145neutrophil activation (GO:0042119)2.43254600
146glucosamine-containing compound catabolic process (GO:1901072)2.42316700
147cellular response to interferon-beta (GO:0035458)2.42263646
148regulation of transmission of nerve impulse (GO:0051969)2.39482118
149pteridine-containing compound biosynthetic process (GO:0042559)2.37909268
150positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.37478560
151immunoglobulin mediated immune response (GO:0016064)2.37470062
152autophagic vacuole fusion (GO:0000046)2.36870267
153erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.36448506
154L-phenylalanine metabolic process (GO:0006558)2.36448506
155negative regulation of thymocyte apoptotic process (GO:0070244)2.35768394
156response to methylmercury (GO:0051597)2.33312419
157regulation of inflammatory response to antigenic stimulus (GO:0002861)2.33243063
158granulocyte activation (GO:0036230)2.32160272
159ubiquinone metabolic process (GO:0006743)2.32159201
160negative regulation of lipid storage (GO:0010888)2.31949135
161negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.29451361
162short-chain fatty acid metabolic process (GO:0046459)2.27434958
163B cell mediated immunity (GO:0019724)2.26192973
164leukocyte degranulation (GO:0043299)2.26129761
165deoxyribonucleotide catabolic process (GO:0009264)2.24378040
166positive regulation of hormone biosynthetic process (GO:0046886)2.22897766
167quinone biosynthetic process (GO:1901663)2.20657773
168deoxyribose phosphate catabolic process (GO:0046386)2.20538047
169positive regulation of monocyte chemotaxis (GO:0090026)2.17363103
170benzene-containing compound metabolic process (GO:0042537)2.15163187
171AMP metabolic process (GO:0046033)2.14741302
172GMP metabolic process (GO:0046037)2.12857144

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.08073838
2E2F7_22180533_ChIP-Seq_HELA_Human3.93393099
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.88509894
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.74624448
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.73181686
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.63456731
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.60208881
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.29751666
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.15960057
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.13090450
11* MYC_18555785_ChIP-Seq_MESCs_Mouse2.99836685
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.95707579
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.93936427
14* SRF_21415370_ChIP-Seq_HL-1_Mouse2.85107273
15PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.77043119
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.69363900
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.67184059
18VDR_23849224_ChIP-Seq_CD4+_Human2.64152023
19* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.63165537
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.60664427
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53552137
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.53130092
23* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.48124405
24* HOXB4_20404135_ChIP-ChIP_EML_Mouse2.42219013
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.35103060
26FOXP3_21729870_ChIP-Seq_TREG_Human2.25080051
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.22520356
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.22327110
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.19922675
30THAP11_20581084_ChIP-Seq_MESCs_Mouse2.16450673
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.15435014
32* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.14529585
33ELK1_19687146_ChIP-ChIP_HELA_Human2.10226586
34DCP1A_22483619_ChIP-Seq_HELA_Human2.06978606
35IRF8_22096565_ChIP-ChIP_GC-B_Human2.03739223
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02528828
37ERG_20887958_ChIP-Seq_HPC-7_Mouse2.02314175
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.98982776
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.98235466
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.97583493
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.96726774
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94475499
43XRN2_22483619_ChIP-Seq_HELA_Human1.92039194
44* GABP_19822575_ChIP-Seq_HepG2_Human1.91217119
45STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.89617099
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.81320917
47* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.80791287
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.71271211
49MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.70145306
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.68358116
51DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.60832942
52E2F4_17652178_ChIP-ChIP_JURKAT_Human1.60530894
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.58760682
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.58372058
55FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.56919242
56IRF8_27001747_Chip-Seq_BMDM_Mouse1.56321564
57MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.54871257
58CIITA_25753668_ChIP-Seq_RAJI_Human1.53068692
59* SPI1_23547873_ChIP-Seq_NB4_Human1.51755381
60* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48432586
61CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.47815627
62TTF2_22483619_ChIP-Seq_HELA_Human1.47379999
63* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47284385
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45341146
65* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.44570351
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40249997
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38632307
68NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.38542512
69GATA3_26560356_Chip-Seq_TH2_Human1.38278649
70HTT_18923047_ChIP-ChIP_STHdh_Human1.35776101
71TFEB_21752829_ChIP-Seq_HELA_Human1.35362919
72MYB_26560356_Chip-Seq_TH2_Human1.34758513
73MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33506006
74STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32906164
75* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31894772
76* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.31871706
77* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31486212
78PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.30511717
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.27628127
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25912314
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25829196
82SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25248937
83MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25087599
84CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.24941367
85MYB_21317192_ChIP-Seq_ERMYB_Mouse1.23615473
86FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.23347728
87POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22100602
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19351611
89NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.18825299
90CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.17561188
91* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13119095
92ELK1_22589737_ChIP-Seq_MCF10A_Human1.12646653
93PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11906551
94VDR_22108803_ChIP-Seq_LS180_Human1.10696699
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08671551
96* SALL4_22934838_ChIP-ChIP_CD34+_Human1.07935443
97ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.07892849
98ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.06626199
99KDM5A_27292631_Chip-Seq_BREAST_Human1.06526142
100TP53_22573176_ChIP-Seq_HFKS_Human1.06332689
101LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05267597
102TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04745224
103ZNF274_21170338_ChIP-Seq_K562_Hela1.03691229
104PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.02977773
105GATA3_27048872_Chip-Seq_THYMUS_Human1.02067887
106EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00843402
107ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00397320
108PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.99949781
109EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99619273
110NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99073068
111* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98629492
112GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98049283
113* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98015279
114SCL_19346495_ChIP-Seq_HPC-7_Human0.98009637
115RXR_22158963_ChIP-Seq_LIVER_Mouse0.97782383
116PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97655197
117* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96675765
118TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96490945
119IGF1R_20145208_ChIP-Seq_DFB_Human0.96207465
120PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96051274
121SMAD_19615063_ChIP-ChIP_OVARY_Human0.94602145
122GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94195154
123TBX5_21415370_ChIP-Seq_HL-1_Mouse0.92917473
124NANOG_19829295_ChIP-Seq_ESCs_Human0.92558109
125SOX2_19829295_ChIP-Seq_ESCs_Human0.92558109
126E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91718645
127PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90956206
128SPI1_23127762_ChIP-Seq_K562_Human0.90402087
129CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89994963
130STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.89834319
131* AR_20517297_ChIP-Seq_VCAP_Human0.89613495
132ELF5_23300383_ChIP-Seq_T47D_Human0.87804328
133FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.87464630
134EZH2_27294783_Chip-Seq_NPCs_Mouse0.85356657
135RUNX_20019798_ChIP-Seq_JUKART_Human0.84606234
136HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84409240
137NFE2_27457419_Chip-Seq_LIVER_Mouse0.83896750
138GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83612096
139NOTCH1_21737748_ChIP-Seq_TLL_Human0.83078130
140RBPJ_22232070_ChIP-Seq_NCS_Mouse0.81794851
141GATA1_22025678_ChIP-Seq_K562_Human0.81321829
142MYC_18940864_ChIP-ChIP_HL60_Human0.80806527
143RUNX1_22412390_ChIP-Seq_EML_Mouse0.80523013
144* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.79491582
145CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79372394
146CTCF_18555785_ChIP-Seq_MESCs_Mouse0.79361875
147E2F1_21310950_ChIP-Seq_MCF-7_Human0.78704210
148HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.76433697

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.68268167
2MP0003186_abnormal_redox_activity3.41824492
3MP0001835_abnormal_antigen_presentation2.95626919
4MP0009785_altered_susceptibility_to2.69886083
5MP0001986_abnormal_taste_sensitivity2.58494341
6MP0002148_abnormal_hypersensitivity_rea2.49308781
7MP0002396_abnormal_hematopoietic_system2.37203875
8MP0001764_abnormal_homeostasis2.19790127
9MP0006036_abnormal_mitochondrial_physio2.18621498
10MP0008058_abnormal_DNA_repair2.16452296
11MP0001661_extended_life_span2.15632755
12MP0009333_abnormal_splenocyte_physiolog2.11285342
13MP0001853_heart_inflammation2.05449937
14MP0006054_spinal_hemorrhage2.01005120
15MP0005671_abnormal_response_to2.00248741
16MP0004147_increased_porphyrin_level1.97911965
17MP0002837_dystrophic_cardiac_calcinosis1.97711568
18MP0003656_abnormal_erythrocyte_physiolo1.96693462
19MP0009697_abnormal_copulation1.91370337
20MP0008995_early_reproductive_senescence1.88272857
21MP0005058_abnormal_lysosome_morphology1.87949915
22MP0003693_abnormal_embryo_hatching1.87904756
23MP0006082_CNS_inflammation1.87583021
24MP0000372_irregular_coat_pigmentation1.85546760
25MP0003724_increased_susceptibility_to1.84323345
26MP0005025_abnormal_response_to1.84237984
27MP0010094_abnormal_chromosome_stability1.81894926
28MP0003763_abnormal_thymus_physiology1.80750472
29MP0002419_abnormal_innate_immunity1.79799672
30MP0005397_hematopoietic_system_phenotyp1.78206592
31MP0001545_abnormal_hematopoietic_system1.78206592
32MP0003183_abnormal_peptide_metabolism1.75647952
33MP0008007_abnormal_cellular_replicative1.74244145
34MP0005000_abnormal_immune_tolerance1.69280755
35MP0002638_abnormal_pupillary_reflex1.67451616
36MP0001529_abnormal_vocalization1.67449168
37MP0002420_abnormal_adaptive_immunity1.67146775
38MP0001819_abnormal_immune_cell1.65708471
39MP0004957_abnormal_blastocyst_morpholog1.62423139
40MP0002452_abnormal_antigen_presenting1.60677361
41MP0002163_abnormal_gland_morphology1.60240238
42MP0008057_abnormal_DNA_replication1.59675481
43MP0005646_abnormal_pituitary_gland1.58151950
44MP0002723_abnormal_immune_serum1.57198986
45MP0000013_abnormal_adipose_tissue1.55821495
46MP0001800_abnormal_humoral_immune1.52746162
47MP0003436_decreased_susceptibility_to1.50628324
48MP0003077_abnormal_cell_cycle1.49006920
49MP0005387_immune_system_phenotype1.48937218
50MP0001790_abnormal_immune_system1.48937218
51MP0000490_abnormal_crypts_of1.47454178
52MP0000685_abnormal_immune_system1.46573191
53MP0002398_abnormal_bone_marrow1.45755565
54MP0009764_decreased_sensitivity_to1.45323520
55MP0005075_abnormal_melanosome_morpholog1.42182126
56MP0002405_respiratory_system_inflammati1.41936495
57MP0002132_abnormal_respiratory_system1.41245787
58MP0005332_abnormal_amino_acid1.40872059
59MP0000639_abnormal_adrenal_gland1.37794411
60MP0003646_muscle_fatigue1.37690665
61MP0003300_gastrointestinal_ulcer1.37571791
62MP0003011_delayed_dark_adaptation1.37168076
63MP0003075_altered_response_to1.36177748
64MP0000716_abnormal_immune_system1.35951209
65MP0000689_abnormal_spleen_morphology1.35715554
66MP0005464_abnormal_platelet_physiology1.35016066
67MP0003191_abnormal_cellular_cholesterol1.34660976
68MP0005410_abnormal_fertilization1.33205691
69MP0006035_abnormal_mitochondrial_morpho1.32504075
70MP0002876_abnormal_thyroid_physiology1.31102968
71MP0005165_increased_susceptibility_to1.30561188
72MP0002429_abnormal_blood_cell1.30338494
73MP0004084_abnormal_cardiac_muscle1.30075116
74MP0001905_abnormal_dopamine_level1.27326911
75MP0002722_abnormal_immune_system1.25488091
76MP0000343_altered_response_to1.25260785
77MP0005319_abnormal_enzyme/_coenzyme1.23791610
78MP0003045_fibrosis1.19511262
79MP0008469_abnormal_protein_level1.18395039
80MP0003172_abnormal_lysosome_physiology1.17669371
81MP0010386_abnormal_urinary_bladder1.17358886
82MP0001845_abnormal_inflammatory_respons1.16306469
83MP0008875_abnormal_xenobiotic_pharmacok1.14753350
84MP0005365_abnormal_bile_salt1.14502607
85MP0008260_abnormal_autophagy1.14383340
86MP0002166_altered_tumor_susceptibility1.12830304
87MP0004036_abnormal_muscle_relaxation1.12632568
88MP0000858_altered_metastatic_potential1.12632152
89MP0005084_abnormal_gallbladder_morpholo1.12065421
90MP0003866_abnormal_defecation1.10187035
91MP0001727_abnormal_embryo_implantation1.10071748
92MP0009379_abnormal_foot_pigmentation1.08041098
93MP0001542_abnormal_bone_strength1.07806972
94MP0002736_abnormal_nociception_after1.06861414
95MP0002019_abnormal_tumor_incidence1.05976578
96MP0005670_abnormal_white_adipose1.04944202
97MP0004782_abnormal_surfactant_physiolog1.04025798
98MP0010155_abnormal_intestine_physiology1.02622476
99MP0000358_abnormal_cell_content/1.02206531
100MP0005330_cardiomyopathy1.01214288
101MP0004215_abnormal_myocardial_fiber1.01148872
102MP0009763_increased_sensitivity_to1.00194179
103MP0008004_abnormal_stomach_pH0.98604693
104MP0005636_abnormal_mineral_homeostasis0.97061089
105MP0002006_tumorigenesis0.97046879
106MP0008775_abnormal_heart_ventricle0.96901231
107MP0000749_muscle_degeneration0.96384127
108MP0001984_abnormal_olfaction0.96029155
109MP0002269_muscular_atrophy0.95942484
110MP0003950_abnormal_plasma_membrane0.95856357
111MP0003111_abnormal_nucleus_morphology0.95852987
112MP0005376_homeostasis/metabolism_phenot0.94072472
113MP0002095_abnormal_skin_pigmentation0.93184897
114MP0010329_abnormal_lipoprotein_level0.92080496
115MP0005266_abnormal_metabolism0.90579210
116MP0009840_abnormal_foam_cell0.90067093
117MP0005535_abnormal_body_temperature0.89800495
118MP0000465_gastrointestinal_hemorrhage0.89553248
119MP0005171_absent_coat_pigmentation0.88611142
120MP0005174_abnormal_tail_pigmentation0.88446290
121MP0002254_reproductive_system_inflammat0.88105204
122MP0003195_calcinosis0.88062931
123MP0002693_abnormal_pancreas_physiology0.87455440
124MP0000681_abnormal_thyroid_gland0.87312583
125MP0002138_abnormal_hepatobiliary_system0.87203707
126MP0008932_abnormal_embryonic_tissue0.85399296
127MP0000569_abnormal_digit_pigmentation0.85089184
128MP0005166_decreased_susceptibility_to0.84972016
129MP0003786_premature_aging0.84960740
130MP0004808_abnormal_hematopoietic_stem0.84491765
131MP0001533_abnormal_skeleton_physiology0.84156163
132MP0002332_abnormal_exercise_endurance0.84038560
133MP0005379_endocrine/exocrine_gland_phen0.83809417
134MP0005584_abnormal_enzyme/coenzyme_acti0.83183204
135MP0004043_abnormal_pH_regulation0.82519338
136MP0009643_abnormal_urine_homeostasis0.81344641
137MP0000230_abnormal_systemic_arterial0.81262054
138MP0000604_amyloidosis0.80435786
139MP0001756_abnormal_urination0.79714342
140MP0001765_abnormal_ion_homeostasis0.79125212

Predicted human phenotypes

RankGene SetZ-score
1Hepatocellular necrosis (HP:0001404)4.83956609
2Hepatic necrosis (HP:0002605)4.63527421
3Mitochondrial inheritance (HP:0001427)4.52792431
4Acute necrotizing encephalopathy (HP:0006965)4.24430169
5Abnormal mitochondria in muscle tissue (HP:0008316)4.15876942
6Increased CSF lactate (HP:0002490)4.05801470
7Stomatitis (HP:0010280)3.71006932
8Type I transferrin isoform profile (HP:0003642)3.70460393
9Acute encephalopathy (HP:0006846)3.65721553
10Progressive macrocephaly (HP:0004481)3.53726537
11Petechiae (HP:0000967)3.43298155
12Renal Fanconi syndrome (HP:0001994)3.40056980
13Increased hepatocellular lipid droplets (HP:0006565)3.35256321
14Generalized aminoaciduria (HP:0002909)3.20637101
15Aplastic anemia (HP:0001915)3.18429796
16Lipid accumulation in hepatocytes (HP:0006561)3.16917417
17Increased serum lactate (HP:0002151)3.16733537
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.09357356
19Decreased activity of mitochondrial respiratory chain (HP:0008972)3.09357356
20Increased serum pyruvate (HP:0003542)3.08891154
21Abnormality of glycolysis (HP:0004366)3.08891154
223-Methylglutaconic aciduria (HP:0003535)2.99919358
23Abnormality of glycolipid metabolism (HP:0010969)2.96924446
24Abnormality of liposaccharide metabolism (HP:0010968)2.96924446
25Abnormality of glycosphingolipid metabolism (HP:0004343)2.96924446
26Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.96166104
27Lactic acidosis (HP:0003128)2.89475487
28Increased intramyocellular lipid droplets (HP:0012240)2.88244410
29Elevated erythrocyte sedimentation rate (HP:0003565)2.81546009
30Abnormal protein glycosylation (HP:0012346)2.80551555
31Abnormal glycosylation (HP:0012345)2.80551555
32Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.80551555
33Abnormal protein N-linked glycosylation (HP:0012347)2.80551555
34Exertional dyspnea (HP:0002875)2.79544614
35Abnormality of polysaccharide metabolism (HP:0011012)2.70483683
36Abnormality of glycosaminoglycan metabolism (HP:0004371)2.70483683
37Abnormality of mucopolysaccharide metabolism (HP:0011020)2.70483683
38Respiratory failure (HP:0002878)2.70235639
39Acute hepatic failure (HP:0006554)2.68880366
40Increased muscle lipid content (HP:0009058)2.67153820
41Hypothermia (HP:0002045)2.65785372
42IgM deficiency (HP:0002850)2.64062009
43Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.63843372
44Abnormal number of erythroid precursors (HP:0012131)2.63308590
45Dysostosis multiplex (HP:0000943)2.62312031
46Mucopolysacchariduria (HP:0008155)2.61229936
47Urinary glycosaminoglycan excretion (HP:0003541)2.61229936
48Exercise intolerance (HP:0003546)2.60585299
49Abnormality of renal resorption (HP:0011038)2.60196482
50Microvesicular hepatic steatosis (HP:0001414)2.57745414
51Hypoglycemic coma (HP:0001325)2.54867308
52Decreased electroretinogram (ERG) amplitude (HP:0000654)2.50931738
53Reduced antithrombin III activity (HP:0001976)2.48175765
54Myositis (HP:0100614)2.47544822
55Prolonged neonatal jaundice (HP:0006579)2.46271692
56Thrombocytosis (HP:0001894)2.44265819
57Cerebral edema (HP:0002181)2.38900046
58Recurrent abscess formation (HP:0002722)2.37557434
59Abnormality of the heme biosynthetic pathway (HP:0010472)2.34213560
60Renal cortical cysts (HP:0000803)2.33083457
61Fatigue (HP:0012378)2.31461422
62Poor head control (HP:0002421)2.31088423
63Abnormality of cells of the erythroid lineage (HP:0012130)2.29772411
64Retrobulbar optic neuritis (HP:0100654)2.28741306
65Optic neuritis (HP:0100653)2.28741306
66Systemic lupus erythematosus (HP:0002725)2.26219431
67CNS demyelination (HP:0007305)2.25528161
68Hypoplasia of the uterus (HP:0000013)2.24894863
69Patchy hypopigmentation of hair (HP:0011365)2.23365880
70White forelock (HP:0002211)2.21385472
71Rhabdomyolysis (HP:0003201)2.20594262
72Hypoplasia of the thymus (HP:0000778)2.19906931
73Increased IgM level (HP:0003496)2.19644912
74Abnormal hair whorl (HP:0010721)2.19602671
75Methylmalonic aciduria (HP:0012120)2.18873458
76Asymmetric septal hypertrophy (HP:0001670)2.18235701
77Vacuolated lymphocytes (HP:0001922)2.17827338
78Abnormality of aromatic amino acid family metabolism (HP:0004338)2.16016906
79Cerebral hypomyelination (HP:0006808)2.15936713
80Birth length less than 3rd percentile (HP:0003561)2.14291748
81Pancytopenia (HP:0001876)2.14072156
82IgG deficiency (HP:0004315)2.13660981
83Myoglobinuria (HP:0002913)2.12646448
84Purpura (HP:0000979)2.11332441
85Abnormality of fatty-acid metabolism (HP:0004359)2.09310330
86Neutropenia (HP:0001875)2.08602892
87Tongue fasciculations (HP:0001308)2.08588801
88Orchitis (HP:0100796)2.08550598
89Leukodystrophy (HP:0002415)2.07196310
90Recurrent bronchitis (HP:0002837)2.06746352
91Neoplasm of head and neck (HP:0012288)2.04966721
92Esophageal neoplasm (HP:0100751)2.04966721
93Ketosis (HP:0001946)2.03912059
94Neuroendocrine neoplasm (HP:0100634)2.03890822
95Lethargy (HP:0001254)2.02220390
96Albinism (HP:0001022)2.00054472
97Hypokinesia (HP:0002375)1.99368530
98Abnormality of the basal ganglia (HP:0002134)1.98169949
99Gingival bleeding (HP:0000225)1.97339339
100Ketoacidosis (HP:0001993)1.97254082
101Reticulocytopenia (HP:0001896)1.97230282
102Abolished electroretinogram (ERG) (HP:0000550)1.95867334
103Recurrent bacterial skin infections (HP:0005406)1.95148111
104Abnormality of methionine metabolism (HP:0010901)1.95044916
105Metaphyseal dysplasia (HP:0100255)1.94905767
106Abnormality of dicarboxylic acid metabolism (HP:0010995)1.94877531
107Dicarboxylic aciduria (HP:0003215)1.94877531
10811 pairs of ribs (HP:0000878)1.94572666
109Loss of speech (HP:0002371)1.94114977
110Abnormality of the anterior horn cell (HP:0006802)1.93874427
111Degeneration of anterior horn cells (HP:0002398)1.93874427
112Respiratory difficulties (HP:0002880)1.93452353
113Aplasia/Hypoplasia of the sacrum (HP:0008517)1.93424567
114Hepatosplenomegaly (HP:0001433)1.92953762
115Neoplasm of the adrenal gland (HP:0100631)1.92932966
116Progressive neurologic deterioration (HP:0002344)1.92579089
117Premature graying of hair (HP:0002216)1.92295284
118Glycosuria (HP:0003076)1.90511727
119Abnormality of urine glucose concentration (HP:0011016)1.90511727
120Nausea (HP:0002018)1.90458425
121Emotional lability (HP:0000712)1.89697634
122Abnormality of T cell physiology (HP:0011840)1.88738752
123Gliosis (HP:0002171)1.87888271
124Testicular neoplasm (HP:0010788)1.87393504
125Abnormality of the renal cortex (HP:0011035)1.86103733
126Hypoglycemic seizures (HP:0002173)1.85443291
127Methylmalonic acidemia (HP:0002912)1.83916415
128Mucosal telangiectasiae (HP:0100579)1.83550362
129Hyperinsulinemic hypoglycemia (HP:0000825)1.82960782
130Hyperglycinemia (HP:0002154)1.81310422
131Agnosia (HP:0010524)1.78684411
132Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.77949224
133Pheochromocytoma (HP:0002666)1.77610088
134Autoimmune hemolytic anemia (HP:0001890)1.77359825
135Type 2 muscle fiber atrophy (HP:0003554)1.76054648
136Aplasia/hypoplasia of the uterus (HP:0008684)1.74798702
137Abnormality of T cells (HP:0002843)1.74282987
138Insulin-resistant diabetes mellitus (HP:0000831)1.74200883
139Hyperammonemia (HP:0001987)1.73578466
140Abnormality of macrophages (HP:0004311)1.72929740
141Abnormal delayed hypersensitivity skin test (HP:0002963)1.72887928
142Renal tubular dysfunction (HP:0000124)1.71739168
143Encephalitis (HP:0002383)1.71434028
144Recurrent pneumonia (HP:0006532)1.69766393
145Palpitations (HP:0001962)1.68552622
146Pulmonary fibrosis (HP:0002206)1.67729586
147Oral leukoplakia (HP:0002745)1.66257451
148Optic disc pallor (HP:0000543)1.65474354
149Muscle fibrillation (HP:0010546)1.65346388

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.46022074
2MAP4K24.17994697
3BUB13.45831518
4TSSK62.58409628
5MAP3K122.53262307
6PIM22.45382080
7EIF2AK32.39095039
8EIF2AK12.35437142
9NME22.29726938
10TIE12.26280094
11CCNB12.16792381
12LMTK22.16781281
13CDK192.13165078
14TEC2.11555311
15BCKDK2.04534590
16VRK12.03533763
17ARAF2.02325383
18IRAK41.94332337
19SIK31.91668199
20NUAK11.88166690
21TGFBR11.82262610
22EPHA31.80128698
23MAP4K11.76200199
24BMPR21.73901657
25PRPF4B1.64856355
26VRK21.59708174
27MST41.57580645
28NLK1.55027350
29EPHB11.53796407
30CDK81.50565677
31BRSK21.48997066
32IRAK21.48738765
33WEE11.46724330
34MYLK1.42785238
35AKT31.39410250
36PDK21.33478807
37CASK1.29722053
38TXK1.28995740
39PASK1.27039309
40STK101.23976788
41OBSCN1.23719082
42FRK1.23336724
43NME11.23150380
44BTK1.22210971
45ERBB31.21867334
46BLK1.19551170
47KIT1.18011833
48PBK1.17112818
49IRAK31.14763180
50MARK31.14192072
51BRAF1.13347853
52SRPK11.13038305
53JAK11.06199249
54TNIK1.04931356
55ACVR1B1.04729796
56PTK2B1.03268013
57TRIM281.01351848
58MAP3K31.00802046
59FER1.00346490
60TNK20.99498390
61TESK20.98667433
62NEK90.98249713
63DAPK10.97441393
64PINK10.96874134
65TGFBR20.94400113
66FLT30.93982406
67FES0.93330241
68NEK10.93309706
69ZAP700.91259396
70MKNK10.90533186
71SYK0.88902726
72CSNK1G10.87550823
73GRK10.85580609
74TESK10.85571523
75ZAK0.83896631
76MAP3K140.81627887
77TBK10.80816244
78GRK70.80689328
79CSF1R0.80168030
80KDR0.79597553
81PHKG10.78594679
82PHKG20.78594679
83MAP3K110.77763050
84RPS6KA40.75704025
85CSNK1G30.75633291
86JAK30.75108929
87PAK30.74841568
88GRK60.73935408
89MAP3K50.72678394
90PRKAA20.71102220
91WNK30.70679519
92CLK10.69690685
93LIMK10.69458517
94IKBKE0.69214946
95OXSR10.67877160
96MAP2K60.66754899
97PLK30.65401846
98PRKCE0.65300404
99BRSK10.64685945
100MAPKAPK50.63556242
101BCR0.62863170
102RIPK40.61191843
103JAK20.60846181
104RPS6KA60.59764439
105PRKG20.59388182
106IKBKB0.57364404
107CSK0.55855037
108RPS6KA50.55391861
109BMPR1B0.55352070
110TLK10.55209971
111MUSK0.54565927
112ATR0.54056204
113DAPK20.52703057
114PIK3CG0.52287087
115LYN0.52269828
116TYK20.52090668
117PRKCQ0.52086903
118HCK0.51931191
119CAMK2D0.51585933
120CAMKK20.51544231
121RPS6KB20.51077345
122RPS6KC10.50201531
123RPS6KL10.50201531
124IGF1R0.47789299
125MAPKAPK30.47193349
126PLK10.46873925
127AURKB0.45979555
128SCYL20.45622275
129CDC70.45598833
130ADRBK20.45567885
131CSNK2A10.45498251
132PLK20.43956756
133CSNK1G20.43386658
134YES10.42733541
135PRKCD0.41982412
136ITK0.41888416
137TRPM70.41149674
138MAP2K30.40425174
139TAOK20.39670642
140PIM10.39179904
141ABL20.39094883
142TAOK30.38764055
143IRAK10.38589761
144DYRK30.37689890
145CSNK2A20.37266173
146CDK70.36999652
147AURKA0.35561004
148ILK0.35389323
149LCK0.34001121

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.30263041
2Protein export_Homo sapiens_hsa030603.90742915
3DNA replication_Homo sapiens_hsa030303.57785262
4Mismatch repair_Homo sapiens_hsa034303.02692560
5Oxidative phosphorylation_Homo sapiens_hsa001903.01154120
6Ribosome_Homo sapiens_hsa030102.94719461
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.62081918
8Base excision repair_Homo sapiens_hsa034102.59249133
9Parkinsons disease_Homo sapiens_hsa050122.52486030
10RNA polymerase_Homo sapiens_hsa030202.43684560
11Vitamin B6 metabolism_Homo sapiens_hsa007502.24505629
12Nucleotide excision repair_Homo sapiens_hsa034202.18337932
13Pyrimidine metabolism_Homo sapiens_hsa002402.11153217
14Homologous recombination_Homo sapiens_hsa034401.84769002
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.78933099
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.75438683
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70248918
18Huntingtons disease_Homo sapiens_hsa050161.70203364
19Alzheimers disease_Homo sapiens_hsa050101.64861510
20Non-homologous end-joining_Homo sapiens_hsa034501.62124110
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60976199
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59916393
23Spliceosome_Homo sapiens_hsa030401.57227580
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.44901474
25Fatty acid elongation_Homo sapiens_hsa000621.44119763
26Folate biosynthesis_Homo sapiens_hsa007901.43754987
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.42241738
28Vibrio cholerae infection_Homo sapiens_hsa051101.40990292
29Collecting duct acid secretion_Homo sapiens_hsa049661.38254502
30Pentose phosphate pathway_Homo sapiens_hsa000301.34560793
31Purine metabolism_Homo sapiens_hsa002301.30116812
32Fructose and mannose metabolism_Homo sapiens_hsa000511.27193789
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26634324
34Autoimmune thyroid disease_Homo sapiens_hsa053201.22622951
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21564776
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.19859660
37Antigen processing and presentation_Homo sapiens_hsa046121.19595743
38One carbon pool by folate_Homo sapiens_hsa006701.16754867
39Staphylococcus aureus infection_Homo sapiens_hsa051501.13522491
40RNA degradation_Homo sapiens_hsa030181.12635101
41Glutathione metabolism_Homo sapiens_hsa004801.10491914
42Pyruvate metabolism_Homo sapiens_hsa006201.05414112
43Tryptophan metabolism_Homo sapiens_hsa003801.05198279
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05040512
45N-Glycan biosynthesis_Homo sapiens_hsa005101.04412088
46Butanoate metabolism_Homo sapiens_hsa006501.04298909
47Carbon metabolism_Homo sapiens_hsa012001.02391823
48Asthma_Homo sapiens_hsa053101.01571230
49Primary immunodeficiency_Homo sapiens_hsa053401.00881476
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00550631
51Legionellosis_Homo sapiens_hsa051340.99896704
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.99782663
53Other glycan degradation_Homo sapiens_hsa005110.98791125
54RNA transport_Homo sapiens_hsa030130.98588443
55Rheumatoid arthritis_Homo sapiens_hsa053230.98061742
56Basal transcription factors_Homo sapiens_hsa030220.97461940
57Fatty acid degradation_Homo sapiens_hsa000710.97291272
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.94689583
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94636802
60Regulation of autophagy_Homo sapiens_hsa041400.92650242
61Circadian rhythm_Homo sapiens_hsa047100.91995648
62Fatty acid metabolism_Homo sapiens_hsa012120.91295881
63Sulfur relay system_Homo sapiens_hsa041220.84930842
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.83347815
65Galactose metabolism_Homo sapiens_hsa000520.82055716
66Phagosome_Homo sapiens_hsa041450.81818630
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.81423419
68Arachidonic acid metabolism_Homo sapiens_hsa005900.78745782
69Propanoate metabolism_Homo sapiens_hsa006400.77888251
70Complement and coagulation cascades_Homo sapiens_hsa046100.75790137
71Metabolic pathways_Homo sapiens_hsa011000.74695407
72Cell cycle_Homo sapiens_hsa041100.73851048
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72112172
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71406668
75Lysosome_Homo sapiens_hsa041420.69091684
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.68086724
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.67024108
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66535207
79Malaria_Homo sapiens_hsa051440.66441568
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.64518276
81Biosynthesis of amino acids_Homo sapiens_hsa012300.64354295
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63691010
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63565367
84Sulfur metabolism_Homo sapiens_hsa009200.63374740
85Epstein-Barr virus infection_Homo sapiens_hsa051690.63242873
86beta-Alanine metabolism_Homo sapiens_hsa004100.62426671
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60528267
88Peroxisome_Homo sapiens_hsa041460.60009543
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59465097
90Ovarian steroidogenesis_Homo sapiens_hsa049130.59360862
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58617778
92Hematopoietic cell lineage_Homo sapiens_hsa046400.58222638
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56194037
94Graft-versus-host disease_Homo sapiens_hsa053320.55073688
95Selenocompound metabolism_Homo sapiens_hsa004500.53330462
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52480263
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52447493
98Pertussis_Homo sapiens_hsa051330.51767040
99Mineral absorption_Homo sapiens_hsa049780.51154798
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50695449
101African trypanosomiasis_Homo sapiens_hsa051430.50647854
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50447550
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.50329625
104Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50242482
105Cardiac muscle contraction_Homo sapiens_hsa042600.48402024
106Chemical carcinogenesis_Homo sapiens_hsa052040.46985415
107Type I diabetes mellitus_Homo sapiens_hsa049400.46670414
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45252355
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44549002
110Shigellosis_Homo sapiens_hsa051310.44029004
111Salmonella infection_Homo sapiens_hsa051320.43492196
112Cyanoamino acid metabolism_Homo sapiens_hsa004600.42944438
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42356451
114Histidine metabolism_Homo sapiens_hsa003400.39957913
115Leishmaniasis_Homo sapiens_hsa051400.39084913
116Fanconi anemia pathway_Homo sapiens_hsa034600.38283998
117Measles_Homo sapiens_hsa051620.38073488
118Renin-angiotensin system_Homo sapiens_hsa046140.37687718
119Allograft rejection_Homo sapiens_hsa053300.37424683
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36900784
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35166021
122Herpes simplex infection_Homo sapiens_hsa051680.33825376
123Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30634212
124Steroid biosynthesis_Homo sapiens_hsa001000.28508257
125NF-kappa B signaling pathway_Homo sapiens_hsa040640.25560288
126Influenza A_Homo sapiens_hsa051640.23734119
127Apoptosis_Homo sapiens_hsa042100.23408728
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23060871
129Sphingolipid metabolism_Homo sapiens_hsa006000.22633049
130Synaptic vesicle cycle_Homo sapiens_hsa047210.21189712
131Tuberculosis_Homo sapiens_hsa051520.20375967

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