BRI3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)5.69031333
2translational termination (GO:0006415)5.30752293
3ribosomal small subunit biogenesis (GO:0042274)5.16616602
4regulation of mononuclear cell migration (GO:0071675)4.46942103
5negative regulation of interleukin-12 production (GO:0032695)4.43937080
6protein targeting to ER (GO:0045047)4.29025545
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.20888658
8amino sugar catabolic process (GO:0046348)4.20356023
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.18529576
10cotranslational protein targeting to membrane (GO:0006613)4.12266556
11establishment of protein localization to endoplasmic reticulum (GO:0072599)4.10327389
12viral life cycle (GO:0019058)4.05084136
13translational elongation (GO:0006414)4.03371416
14protein localization to endoplasmic reticulum (GO:0070972)3.94880921
15respiratory electron transport chain (GO:0022904)3.94408325
16virion attachment to host cell (GO:0019062)3.93644774
17adhesion of symbiont to host cell (GO:0044650)3.93644774
18electron transport chain (GO:0022900)3.82632555
19cellular protein complex disassembly (GO:0043624)3.73712022
20ATP synthesis coupled proton transport (GO:0015986)3.73028030
21energy coupled proton transport, down electrochemical gradient (GO:0015985)3.73028030
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.71733137
23glycosphingolipid catabolic process (GO:0046479)3.63429797
24negative regulation of cell killing (GO:0031342)3.61980812
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.61980812
26nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.57367341
27oligosaccharide catabolic process (GO:0009313)3.54447331
28regulation of mast cell degranulation (GO:0043304)3.42887620
29adhesion of symbiont to host (GO:0044406)3.38290875
30detection of molecule of bacterial origin (GO:0032490)3.33578424
31modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.33180535
32modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.33180535
33positive regulation by organism of defense response of other organism involved in symbiotic interact3.33180535
34modulation by symbiont of host immune response (GO:0052553)3.33180535
35positive regulation by symbiont of host defense response (GO:0052509)3.33180535
36modulation by symbiont of host defense response (GO:0052031)3.33180535
37translational initiation (GO:0006413)3.26190732
38detection of other organism (GO:0098543)3.25922540
39glycolipid catabolic process (GO:0019377)3.24742836
40N-acetylneuraminate metabolic process (GO:0006054)3.24445251
41positive regulation of lipid storage (GO:0010884)3.14047786
42phagosome maturation (GO:0090382)3.13298242
43positive regulation of mast cell activation (GO:0033005)3.10380176
44regulation of mast cell activation involved in immune response (GO:0033006)3.09104734
45detection of external biotic stimulus (GO:0098581)3.07899857
46positive regulation of mast cell activation involved in immune response (GO:0033008)3.07478315
47positive regulation of mast cell degranulation (GO:0043306)3.07478315
48neutrophil activation involved in immune response (GO:0002283)3.06029846
49detection of bacterium (GO:0016045)3.04718039
50positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.03398618
51cellular response to virus (GO:0098586)3.02104074
52protein complex disassembly (GO:0043241)3.01913660
53ribosomal large subunit biogenesis (GO:0042273)3.01495376
54cytidine metabolic process (GO:0046087)3.00891453
55cytidine catabolic process (GO:0006216)3.00891453
56cytidine deamination (GO:0009972)3.00891453
57hydrogen peroxide biosynthetic process (GO:0050665)3.00508357
58regulation of leukocyte degranulation (GO:0043300)2.96671523
59protein targeting to membrane (GO:0006612)2.96366004
60response to peptidoglycan (GO:0032494)2.94350723
61barbed-end actin filament capping (GO:0051016)2.94320323
62ceramide catabolic process (GO:0046514)2.93473131
63regulation of sequestering of triglyceride (GO:0010889)2.92114893
64regulation of myeloid leukocyte mediated immunity (GO:0002886)2.89036536
65T-helper 1 type immune response (GO:0042088)2.85151658
66cellular extravasation (GO:0045123)2.84741457
67regulation of early endosome to late endosome transport (GO:2000641)2.84650530
68regulation of interferon-beta biosynthetic process (GO:0045357)2.84132342
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.81496022
70regulation of mast cell activation (GO:0033003)2.81180436
71superoxide anion generation (GO:0042554)2.81006092
72negative regulation of interleukin-1 production (GO:0032692)2.80855275
73tooth mineralization (GO:0034505)2.80511052
74positive regulation of leukocyte degranulation (GO:0043302)2.79202737
75macromolecular complex disassembly (GO:0032984)2.76720664
76lipopolysaccharide-mediated signaling pathway (GO:0031663)2.74866010
77macrophage activation (GO:0042116)2.73630738
78positive regulation of chemokine biosynthetic process (GO:0045080)2.73461327
79respiratory burst (GO:0045730)2.71534921
80detection of biotic stimulus (GO:0009595)2.69703535
81negative regulation of tumor necrosis factor production (GO:0032720)2.69643341
82pattern specification involved in kidney development (GO:0061004)2.69343856
83immunoglobulin mediated immune response (GO:0016064)2.69076907
84sarcomere organization (GO:0045214)2.68547576
85negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.67648746
86response to host immune response (GO:0052572)2.67144246
87response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.67144246
88response to increased oxygen levels (GO:0036296)2.65417290
89response to hyperoxia (GO:0055093)2.65417290
90negative regulation of interleukin-6 production (GO:0032715)2.65313191
91negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.65172323
92maternal placenta development (GO:0001893)2.63641586
93protein neddylation (GO:0045116)2.63615340
94positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.63296514
95negative regulation of nitric oxide biosynthetic process (GO:0045019)2.63266888
96neutrophil activation (GO:0042119)2.62672757
97regulation of monocyte chemotaxis (GO:0090025)2.62063610
98antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.59909805
99regulation of antigen processing and presentation (GO:0002577)2.57904046
100cellular response to nicotine (GO:0071316)2.57305957
101regulation of dendritic cell antigen processing and presentation (GO:0002604)2.56935162
102negative regulation of cytokine production involved in immune response (GO:0002719)2.56746266
103low-density lipoprotein particle clearance (GO:0034383)2.55656113
104antigen processing and presentation of endogenous antigen (GO:0019883)2.53940322
105positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.53846661
106positive regulation of protein kinase C signaling (GO:0090037)2.53320984
107sphingolipid catabolic process (GO:0030149)2.51726160
108positive regulation of lymphocyte apoptotic process (GO:0070230)2.50701385
109regulation of cholesterol storage (GO:0010885)2.50600108
110membrane lipid catabolic process (GO:0046466)2.50513921
111response to muramyl dipeptide (GO:0032495)2.49670383
112protein localization to endosome (GO:0036010)2.49396323
113myeloid cell activation involved in immune response (GO:0002275)2.49303817
114eosinophil chemotaxis (GO:0048245)2.48855215
115regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.48695528
116response to host (GO:0075136)2.48187322
117response to host defenses (GO:0052200)2.48187322
118response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.48187322
119regulation of superoxide anion generation (GO:0032928)2.47698344
120negative regulation of interleukin-1 beta production (GO:0032691)2.47581790
121NIK/NF-kappaB signaling (GO:0038061)2.46514482
122sulfur amino acid catabolic process (GO:0000098)2.46440146
123regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.46261944
124positive regulation of cellular amide metabolic process (GO:0034250)2.46032430
125positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.45784982
126mannose metabolic process (GO:0006013)2.45338496
127response to acidic pH (GO:0010447)2.45227263
128leukocyte migration involved in inflammatory response (GO:0002523)2.45031725
129negative regulation of erythrocyte differentiation (GO:0045647)2.44017286
130growth hormone receptor signaling pathway (GO:0060396)2.42660184
131myeloid dendritic cell differentiation (GO:0043011)2.42188759
132regulation of regulated secretory pathway (GO:1903305)2.41139154
133negative regulation of innate immune response (GO:0045824)2.40506783
134regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.40249956
135positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.40087151
136antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.39499719
137positive regulation of gamma-delta T cell activation (GO:0046645)2.38230963
138reactive oxygen species biosynthetic process (GO:1903409)2.38152188
139monocyte chemotaxis (GO:0002548)2.37907943
140regulation of T-helper 1 cell differentiation (GO:0045625)2.36564232
141positive regulation of monocyte chemotaxis (GO:0090026)2.35574449
142macrophage activation involved in immune response (GO:0002281)2.34428053
143short-term memory (GO:0007614)2.34326998
144cardiac muscle cell development (GO:0055013)2.34039700
145negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.30638283
146bundle of His cell to Purkinje myocyte communication (GO:0086069)2.29697476
147positive regulation of interferon-alpha production (GO:0032727)2.29688555
148cellular response to thyroid hormone stimulus (GO:0097067)2.27427553
149aldehyde catabolic process (GO:0046185)2.27367024
150segment specification (GO:0007379)2.26193882
151regulation of p38MAPK cascade (GO:1900744)2.26047358
152negative regulation of macroautophagy (GO:0016242)2.25361313
153positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.24845494
154granulocyte activation (GO:0036230)2.22003435
155regulation of macrophage chemotaxis (GO:0010758)2.21102047
156regulation of interferon-alpha production (GO:0032647)2.19871919
157regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.19798221
158nitric oxide biosynthetic process (GO:0006809)2.18628883
159diol metabolic process (GO:0034311)2.18380384
160cardiac cell development (GO:0055006)2.17505305
161regulation of lipid storage (GO:0010883)2.17352421
162glyoxylate metabolic process (GO:0046487)2.16456010
163positive regulation of antigen processing and presentation (GO:0002579)2.14544443
164eosinophil migration (GO:0072677)2.13844995
165short-chain fatty acid metabolic process (GO:0046459)2.12659088
166L-phenylalanine metabolic process (GO:0006558)2.12379632
167erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.12379632
168plasma lipoprotein particle clearance (GO:0034381)2.11689762
169maturation of SSU-rRNA (GO:0030490)2.11007731
170response to thyroid hormone (GO:0097066)2.10907754
171cysteine metabolic process (GO:0006534)2.10907619
172regulation of integrin activation (GO:0033623)2.10135003
173cardiac myofibril assembly (GO:0055003)2.09861774
174myeloid cell homeostasis (GO:0002262)2.09002891

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.69938546
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.22067614
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.89747293
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.94553082
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.80277307
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.70301065
7* RXR_22158963_ChIP-Seq_LIVER_Mouse2.50299670
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.42376646
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.37090780
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.28373143
11CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.28273288
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.26647581
13* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.26053295
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.24502214
15CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.19792282
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.16013643
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.12689495
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.99851638
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.98593505
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97349432
21* LXR_22158963_ChIP-Seq_LIVER_Mouse1.89292288
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89232564
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88213410
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.85747963
25IRF8_27001747_Chip-Seq_BMDM_Mouse1.83194326
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.81559944
27FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.77007412
28CDX2_20551321_ChIP-Seq_CACO-2_Human1.73915880
29TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.73261518
30ZNF263_19887448_ChIP-Seq_K562_Human1.72535000
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.71139504
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67969987
33BCL6_27268052_Chip-Seq_Bcells_Human1.65323837
34NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64905815
35SPI1_23127762_ChIP-Seq_K562_Human1.63751696
36CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.61959659
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60724672
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.60715916
39KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.59933755
40KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.59933755
41KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.59933755
42VDR_21846776_ChIP-Seq_THP-1_Human1.58304780
43* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.56271994
44SRY_22984422_ChIP-ChIP_TESTIS_Rat1.51345814
45VDR_24763502_ChIP-Seq_THP-1_Human1.51008992
46* ELK3_25401928_ChIP-Seq_HUVEC_Human1.50687702
47RACK7_27058665_Chip-Seq_MCF-7_Human1.47748348
48* LXR_22292898_ChIP-Seq_THP-1_Human1.47386889
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.46348983
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.45410885
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44694009
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44229157
53P68_20966046_ChIP-Seq_HELA_Human1.43809232
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43569717
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43387835
56SPI1_23547873_ChIP-Seq_NB4_Human1.40858545
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.40045987
58KDM2B_26808549_Chip-Seq_K562_Human1.39150651
59TCF3_18692474_ChIP-Seq_MEFs_Mouse1.38847242
60PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37059311
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35587682
62ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.34864543
63GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.32051495
64SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31028763
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29980802
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28942578
67PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28433455
68STAT4_19710469_ChIP-ChIP_TH1__Mouse1.28379919
69NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.28331901
70LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27234878
71SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25947267
72PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.25305364
73STAT1_20625510_ChIP-Seq_HELA_Human1.23578783
74ATF3_27146783_Chip-Seq_COLON_Human1.22894465
75SOX2_18692474_ChIP-Seq_MEFs_Mouse1.22731878
76P63_26484246_Chip-Seq_KERATINOCYTES_Human1.22619035
77MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21625923
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18951487
79SMC1_22415368_ChIP-Seq_MEFs_Mouse1.18104072
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17644420
81CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17220741
82SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.16343811
83IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16096555
84ESR2_21235772_ChIP-Seq_MCF-7_Human1.15925653
85GATA1_19941827_ChIP-Seq_MEL_Mouse1.15656529
86CTCF_26484167_Chip-Seq_Bcells_Mouse1.15410395
87TP53_22127205_ChIP-Seq_IMR90_Human1.14766063
88CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14346878
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.14026104
90DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13922949
91VDR_24787735_ChIP-Seq_THP-1_Human1.13488248
92TP53_20018659_ChIP-ChIP_R1E_Mouse1.12376743
93SMC3_22415368_ChIP-Seq_MEFs_Mouse1.12078886
94* SOX2_20726797_ChIP-Seq_SW620_Human1.11699068
95CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11383805
96STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.09651105
97CTCF_20526341_ChIP-Seq_ESCs_Human1.09588074
98UTX_26944678_Chip-Seq_JUKART_Human1.09587677
99* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09460270
100FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09413108
101PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08947226
102ERG_21242973_ChIP-ChIP_JURKAT_Human1.08213340
103SMC4_20622854_ChIP-Seq_HELA_Human1.07125920
104NANOG_18692474_ChIP-Seq_MEFs_Mouse1.07017310
105HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06870574
106EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06797997
107OCT4_18692474_ChIP-Seq_MEFs_Mouse1.05756290
108CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04888861
109KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04712456
110STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.04423291
111E2F1_20622854_ChIP-Seq_HELA_Human1.03299833
112MAF_26560356_Chip-Seq_TH1_Human1.02547594
113PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02023694
114ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.01885590
115CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01671393
116SPI1_20517297_ChIP-Seq_HL60_Human1.01621785
117KDM2B_26808549_Chip-Seq_JURKAT_Human1.01199534
118FOXO3_23340844_ChIP-Seq_DLD1_Human1.00661939
119MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00586197
120CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99977247
121UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99356187
122CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98903931
123CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98721242
124CTCF_21964334_Chip-Seq_Bcells_Human0.98372379
125PHF8_20622854_ChIP-Seq_HELA_Human0.97383004
126GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97377749
127KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96020711
128CTCF_27219007_Chip-Seq_Bcells_Human0.95574201
129SA1_27219007_Chip-Seq_Bcells_Human0.95561661
130NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95175395
131MAF_26560356_Chip-Seq_TH2_Human0.93572355
132BCOR_27268052_Chip-Seq_Bcells_Human0.93135905
133STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93125095
134RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92257072
135TET1_21451524_ChIP-Seq_MESCs_Mouse0.91579624
136EGR1_19032775_ChIP-ChIP_M12_Human0.90884042
137TCF7_22412390_ChIP-Seq_EML_Mouse0.90754996
138SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89063569
139KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88866769
140NANOG_20526341_ChIP-Seq_ESCs_Human0.88441616
141SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88392406
142KDM2B_26808549_Chip-Seq_DND41_Human0.88292640
143GATA6_25053715_ChIP-Seq_YYC3_Human0.88222911
144CTCF_21964334_ChIP-Seq_BJAB-B_Human0.86448766
145ELK1_22589737_ChIP-Seq_MCF10A_Human0.86130434
146EGR1_23403033_ChIP-Seq_LIVER_Mouse0.85534031
147GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83542084

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.77210472
2MP0003646_muscle_fatigue3.61659894
3MP0003172_abnormal_lysosome_physiology2.99178926
4MP0002138_abnormal_hepatobiliary_system2.97848817
5MP0004185_abnormal_adipocyte_glucose2.66406031
6MP0009379_abnormal_foot_pigmentation2.65196630
7MP0003828_pulmonary_edema2.62991468
8MP0004510_myositis2.51479014
9MP0009840_abnormal_foam_cell2.31921037
10MP0005451_abnormal_body_composition2.30700973
11MP0005058_abnormal_lysosome_morphology2.24785183
12MP0003436_decreased_susceptibility_to2.20213656
13MP0006082_CNS_inflammation2.20015783
14MP0003724_increased_susceptibility_to2.04304497
15MP0000604_amyloidosis2.03671051
16MP0000750_abnormal_muscle_regeneration2.02584866
17MP0005257_abnormal_intraocular_pressure2.00412244
18MP0002837_dystrophic_cardiac_calcinosis1.99712752
19MP0005360_urolithiasis1.90149372
20MP0002277_abnormal_respiratory_mucosa1.89821185
21MP0004858_abnormal_nervous_system1.86810346
22MP0003136_yellow_coat_color1.83727398
23MP0002998_abnormal_bone_remodeling1.82437495
24MP0003806_abnormal_nucleotide_metabolis1.81734219
25MP0003011_delayed_dark_adaptation1.75690366
26MP0002148_abnormal_hypersensitivity_rea1.74969094
27MP0005666_abnormal_adipose_tissue1.73808415
28MP0005083_abnormal_biliary_tract1.72435513
29MP0001542_abnormal_bone_strength1.65827568
30MP0000343_altered_response_to1.62776444
31MP0002723_abnormal_immune_serum1.61757302
32MP0003279_aneurysm1.60093774
33MP0008875_abnormal_xenobiotic_pharmacok1.56393110
34MP0009785_altered_susceptibility_to1.49328638
35MP0009278_abnormal_bone_marrow1.48078261
36MP0005330_cardiomyopathy1.45060089
37MP0008438_abnormal_cutaneous_collagen1.41559906
38MP0002420_abnormal_adaptive_immunity1.40546646
39MP0003191_abnormal_cellular_cholesterol1.40327252
40MP0001819_abnormal_immune_cell1.40288343
41MP0001800_abnormal_humoral_immune1.39601893
42MP0005671_abnormal_response_to1.38742871
43MP0005464_abnormal_platelet_physiology1.38648693
44MP0005025_abnormal_response_to1.35928992
45MP0004130_abnormal_muscle_cell1.33987607
46MP0002139_abnormal_hepatobiliary_system1.33314557
47MP0003879_abnormal_hair_cell1.33147967
48MP0003186_abnormal_redox_activity1.32280086
49MP0003315_abnormal_perineum_morphology1.31483181
50MP0000685_abnormal_immune_system1.31416612
51MP0009053_abnormal_anal_canal1.30701783
52MP0003221_abnormal_cardiomyocyte_apopto1.30404462
53MP0005165_increased_susceptibility_to1.28147621
54MP0005000_abnormal_immune_tolerance1.26604333
55MP0001958_emphysema1.24442879
56MP0002419_abnormal_innate_immunity1.23984343
57MP0001790_abnormal_immune_system1.23463368
58MP0005387_immune_system_phenotype1.23463368
59MP0002332_abnormal_exercise_endurance1.22337043
60MP0008260_abnormal_autophagy1.21851638
61MP0002249_abnormal_larynx_morphology1.20931454
62MP0004019_abnormal_vitamin_homeostasis1.19286658
63MP0005085_abnormal_gallbladder_physiolo1.17801520
64MP0009333_abnormal_splenocyte_physiolog1.17783442
65MP0003453_abnormal_keratinocyte_physiol1.17454278
66MP0001835_abnormal_antigen_presentation1.16785590
67MP0009764_decreased_sensitivity_to1.13913207
68MP0003329_amyloid_beta_deposits1.11998061
69MP0004947_skin_inflammation1.10147925
70MP0002972_abnormal_cardiac_muscle1.09890687
71MP0003448_altered_tumor_morphology1.09264595
72MP0003195_calcinosis1.08820382
73MP0004084_abnormal_cardiac_muscle1.06705311
74MP0002796_impaired_skin_barrier1.05577656
75MP0005332_abnormal_amino_acid1.05467055
76MP0003183_abnormal_peptide_metabolism1.05181508
77MP0010368_abnormal_lymphatic_system1.05154150
78MP0001544_abnormal_cardiovascular_syste1.04624004
79MP0005385_cardiovascular_system_phenoty1.04624004
80MP0009250_abnormal_appendicular_skeleto1.03621959
81MP0005310_abnormal_salivary_gland1.03293762
82MP0000751_myopathy1.02742904
83MP0008469_abnormal_protein_level1.02205576
84MP0005166_decreased_susceptibility_to1.00752988
85MP0002282_abnormal_trachea_morphology1.00606552
86MP0002971_abnormal_brown_adipose0.98826496
87MP0001853_heart_inflammation0.97567275
88MP0003690_abnormal_glial_cell0.95117258
89MP0003137_abnormal_impulse_conducting0.95048247
90MP0005084_abnormal_gallbladder_morpholo0.94602174
91MP0009643_abnormal_urine_homeostasis0.94470093
92MP0005167_abnormal_blood-brain_barrier0.93433626
93MP0005595_abnormal_vascular_smooth0.93429222
94MP0004087_abnormal_muscle_fiber0.93211042
95MP0000767_abnormal_smooth_muscle0.92591348
96MP0005397_hematopoietic_system_phenotyp0.92551064
97MP0001545_abnormal_hematopoietic_system0.92551064
98MP0005023_abnormal_wound_healing0.92057062
99MP0001533_abnormal_skeleton_physiology0.91984935
100MP0000858_altered_metastatic_potential0.90697497
101MP0000049_abnormal_middle_ear0.89995330
102MP0008004_abnormal_stomach_pH0.89053018
103MP0004782_abnormal_surfactant_physiolog0.88979865
104MP0004883_abnormal_blood_vessel0.88481618
105MP0010630_abnormal_cardiac_muscle0.88334820
106MP0002452_abnormal_antigen_presenting0.88151695
107MP0001663_abnormal_digestive_system0.87136401
108MP0002102_abnormal_ear_morphology0.86754735
109MP0002405_respiratory_system_inflammati0.86201226
110MP0005381_digestive/alimentary_phenotyp0.85811006
111MP0004381_abnormal_hair_follicle0.85159578
112MP0003795_abnormal_bone_structure0.84922085
113MP0004484_altered_response_of0.84369748
114MP0000749_muscle_degeneration0.82983599
115MP0003075_altered_response_to0.82384531
116MP0005164_abnormal_response_to0.81544462
117MP0002132_abnormal_respiratory_system0.81300413
118MP0000490_abnormal_crypts_of0.81280408
119MP0000716_abnormal_immune_system0.81069603
120MP0008775_abnormal_heart_ventricle0.80174953
121MP0004215_abnormal_myocardial_fiber0.80168645
122MP0002653_abnormal_ependyma_morphology0.79543186
123MP0001845_abnormal_inflammatory_respons0.79222250
124MP0004036_abnormal_muscle_relaxation0.78724301
125MP0005365_abnormal_bile_salt0.78649091
126MP0003705_abnormal_hypodermis_morpholog0.77330590
127MP0006054_spinal_hemorrhage0.75644762
128MP0002106_abnormal_muscle_physiology0.75606607
129MP0005197_abnormal_uvea_morphology0.75500999
130MP0000613_abnormal_salivary_gland0.74852313
131MP0005390_skeleton_phenotype0.74797214
132MP0002254_reproductive_system_inflammat0.74107998
133MP0005319_abnormal_enzyme/_coenzyme0.73839553
134MP0003300_gastrointestinal_ulcer0.73772436
135MP0000249_abnormal_blood_vessel0.73354469
136MP0002933_joint_inflammation0.72447444
137MP0010155_abnormal_intestine_physiology0.71835361
138MP0000920_abnormal_myelination0.67020719
139MP0000371_diluted_coat_color0.66432610
140MP0003091_abnormal_cell_migration0.65862764
141MP0002896_abnormal_bone_mineralization0.65774815
142MP0000681_abnormal_thyroid_gland0.62800020

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)7.23162728
2Abnormality of glycosphingolipid metabolism (HP:0004343)7.23162728
3Abnormality of glycolipid metabolism (HP:0010969)7.23162728
4Increased cerebral lipofuscin (HP:0011813)4.98039507
5Concave nail (HP:0001598)4.49544577
6Increased neuronal autofluorescent lipopigment (HP:0002074)4.29781391
7Sudden death (HP:0001699)3.81008623
8Loss of speech (HP:0002371)3.80292688
9Abnormality of polysaccharide metabolism (HP:0011012)3.74475590
10Abnormality of glycosaminoglycan metabolism (HP:0004371)3.74475590
11Abnormality of mucopolysaccharide metabolism (HP:0011020)3.74475590
12Abnormal hemoglobin (HP:0011902)3.67848313
13Eczematoid dermatitis (HP:0000976)3.40926903
14Ventricular tachycardia (HP:0004756)3.38892587
15Axonal loss (HP:0003447)3.38750617
16Recurrent abscess formation (HP:0002722)3.34736850
17Myositis (HP:0100614)3.33160832
18Vacuolated lymphocytes (HP:0001922)3.30994849
19Acute necrotizing encephalopathy (HP:0006965)3.16946767
20Recurrent gram-negative bacterial infections (HP:0005420)3.16848943
21Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.14162246
22Systemic lupus erythematosus (HP:0002725)3.11577841
23Disinhibition (HP:0000734)3.10150701
24Acute encephalopathy (HP:0006846)3.08062678
25Vertebral compression fractures (HP:0002953)3.05782975
26Increased muscle lipid content (HP:0009058)3.03347378
27Abnormality of macrophages (HP:0004311)3.02907340
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.01834527
29Recurrent bacterial skin infections (HP:0005406)2.96172391
30Multiple enchondromatosis (HP:0005701)2.95334663
31Increased intramyocellular lipid droplets (HP:0012240)2.94494561
32Abnormal mitochondria in muscle tissue (HP:0008316)2.92055499
33Lipid accumulation in hepatocytes (HP:0006561)2.88635431
34Purpura (HP:0000979)2.87372101
35Mitochondrial inheritance (HP:0001427)2.86259012
36Glomerulonephritis (HP:0000099)2.85822427
37Exertional dyspnea (HP:0002875)2.83487403
38Increased hepatocellular lipid droplets (HP:0006565)2.81820985
39Mutism (HP:0002300)2.80009686
40Nuclear cataract (HP:0100018)2.79846424
41Mediastinal lymphadenopathy (HP:0100721)2.78220775
42Neurofibrillary tangles (HP:0002185)2.73851801
43Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.73686895
44Decreased activity of mitochondrial respiratory chain (HP:0008972)2.73686895
45Reticulocytopenia (HP:0001896)2.69737326
46Asymmetric septal hypertrophy (HP:0001670)2.69707724
47Prolonged neonatal jaundice (HP:0006579)2.62438958
48Abnormal cartilage morphology (HP:0002763)2.60135676
49Hepatic necrosis (HP:0002605)2.58683625
50Retrobulbar optic neuritis (HP:0100654)2.55364522
51Optic neuritis (HP:0100653)2.55364522
52Myocardial infarction (HP:0001658)2.55101430
53Aplasia/Hypoplasia of the sacrum (HP:0008517)2.54390910
54Renal Fanconi syndrome (HP:0001994)2.53769507
55Progressive neurologic deterioration (HP:0002344)2.53411943
56Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.52261501
57Hepatocellular necrosis (HP:0001404)2.50849070
58Right ventricular cardiomyopathy (HP:0011663)2.49266013
59Cerebral edema (HP:0002181)2.46855395
60Spontaneous hematomas (HP:0007420)2.45209817
61Progressive macrocephaly (HP:0004481)2.44425056
62Xanthomatosis (HP:0000991)2.41422191
63Respiratory failure (HP:0002878)2.40738993
64Nausea (HP:0002018)2.40604504
65Abnormality of aromatic amino acid family metabolism (HP:0004338)2.39592771
66Polycythemia (HP:0001901)2.39361837
67Dysostosis multiplex (HP:0000943)2.38860077
68Macrocytic anemia (HP:0001972)2.35817142
69Petechiae (HP:0000967)2.34354404
70Pallor (HP:0000980)2.33513265
71Lipoatrophy (HP:0100578)2.30638231
72Hyperphosphaturia (HP:0003109)2.30465814
73Abnormality of the nasal mucosa (HP:0000433)2.30437940
74Abnormality of the Achilles tendon (HP:0005109)2.28522952
75Esophageal neoplasm (HP:0100751)2.27222700
76Neoplasm of head and neck (HP:0012288)2.27222700
77Testicular atrophy (HP:0000029)2.27170864
78Achilles tendon contracture (HP:0001771)2.26911909
79Abnormality of cells of the erythroid lineage (HP:0012130)2.26690842
80Stomatitis (HP:0010280)2.25194977
81Malnutrition (HP:0004395)2.25001875
82Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.22920980
83Joint stiffness (HP:0001387)2.21330641
84Pathologic fracture (HP:0002756)2.16749379
85Increased CSF lactate (HP:0002490)2.14579143
86Hematochezia (HP:0002573)2.13888190
87Upper motor neuron abnormality (HP:0002127)2.13720305
88Abnormal urine phosphate concentration (HP:0012599)2.12535893
89Fragile nails (HP:0001808)2.10669325
90Abnormality of the vasculature of the conjunctiva (HP:0008054)2.09870189
91Abnormality of iron homeostasis (HP:0011031)2.09781519
92Progressive muscle weakness (HP:0003323)2.09405882
93Hyperglycinuria (HP:0003108)2.08995577
94Muscle hypertrophy of the lower extremities (HP:0008968)2.08816380
95Urticaria (HP:0001025)2.08333516
96Abnormality of complement system (HP:0005339)2.07816330
97Protrusio acetabuli (HP:0003179)2.07608173
98Chronic obstructive pulmonary disease (HP:0006510)2.05536610
99Obstructive lung disease (HP:0006536)2.05536610
100Diminished motivation (HP:0000745)2.05111143
101Orchitis (HP:0100796)2.04530989
102Nephritis (HP:0000123)2.04376170
103Amyloidosis (HP:0011034)2.04177363
104Cervical subluxation (HP:0003308)2.03971183
105Hepatosplenomegaly (HP:0001433)2.03568850
106Increased serum ferritin (HP:0003281)2.01817125
107Pulmonary infiltrates (HP:0002113)2.00662952
108Syncope (HP:0001279)2.00499559
109Abnormality of dicarboxylic acid metabolism (HP:0010995)2.00205195
110Dicarboxylic aciduria (HP:0003215)2.00205195
111Ovoid vertebral bodies (HP:0003300)1.99205550
112Calf muscle hypertrophy (HP:0008981)1.98496198
113Hyperglycinemia (HP:0002154)1.96699973
114Muscle fiber splitting (HP:0003555)1.93751243
115Glycosuria (HP:0003076)1.93143234
116Abnormality of urine glucose concentration (HP:0011016)1.93143234
117Peritonitis (HP:0002586)1.93115430
118Gastrointestinal infarctions (HP:0005244)1.92768562
119Abnormality of the phalanges of the hallux (HP:0010057)1.92432897
120Cardiomegaly (HP:0001640)1.91039562
121Hemoptysis (HP:0002105)1.89592296
122Abnormality of glutamine family amino acid metabolism (HP:0010902)1.89033719
123Lethargy (HP:0001254)1.88969126
124Elevated erythrocyte sedimentation rate (HP:0003565)1.88861361
125Recurrent skin infections (HP:0001581)1.88612432
126Cupped ribs (HP:0000887)1.88248350
127Complement deficiency (HP:0004431)1.86401294
128Ridged nail (HP:0001807)1.86266095
129Metaphyseal irregularity (HP:0003025)1.86217163
130Woolly hair (HP:0002224)1.85832302
131Cerebral inclusion bodies (HP:0100314)1.85705246
132Hyperlipoproteinemia (HP:0010980)1.85363229
133Apathy (HP:0000741)1.84324168
134Retinal atrophy (HP:0001105)1.83939624
135Neuronal loss in central nervous system (HP:0002529)1.83436167
136Supranuclear gaze palsy (HP:0000605)1.83246169
137Autoimmune thrombocytopenia (HP:0001973)1.83195892
138Acne (HP:0001061)1.83180752
139Subaortic stenosis (HP:0001682)1.82588820
140Abnormality of the left ventricular outflow tract (HP:0011103)1.82588820
141Dementia (HP:0000726)1.81902313
142Multiple lipomas (HP:0001012)1.80166859
143Bone pain (HP:0002653)1.80123633
144Abnormal number of erythroid precursors (HP:0012131)1.79771133
145Mucopolysacchariduria (HP:0008155)1.79685925
146Urinary glycosaminoglycan excretion (HP:0003541)1.79685925
147Gingivitis (HP:0000230)1.79427544
148Recurrent fungal infections (HP:0002841)1.79405514
149Thin bony cortex (HP:0002753)1.75563758
150Gout (HP:0001997)1.74907816
151Exercise intolerance (HP:0003546)1.74801626
152Thoracic kyphosis (HP:0002942)1.73987078
153Pustule (HP:0200039)1.73764085
154Abnormality of glycine metabolism (HP:0010895)1.73228264
155Hypophosphatemia (HP:0002148)1.71577380
156Segmental peripheral demyelination/remyelination (HP:0003481)1.71441339
157Episodic fever (HP:0001954)1.70681790
158J-shaped sella turcica (HP:0002680)1.70647733
159Vasculitis (HP:0002633)1.70209432
160Abnormality of transition element cation homeostasis (HP:0011030)1.69928836
161Premature loss of primary teeth (HP:0006323)1.69190442
162Emphysema (HP:0002097)1.65996923
163Bone cyst (HP:0012062)1.64661304
164Premature rupture of membranes (HP:0001788)1.64425562
165Hypertensive crisis (HP:0100735)1.61409697
166Restrictive lung disease (HP:0002091)1.60542497
167Genu recurvatum (HP:0002816)1.59186459

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.96480477
2TAOK34.02679641
3NME23.76647902
4EPHB23.14686257
5BLK2.63156667
6MAP2K32.48042047
7ABL22.39046412
8TRIB32.34037162
9TBK12.21152240
10ERN12.19812092
11RIPK42.18939394
12LATS21.99147931
13PIM21.95233853
14MST1R1.81853763
15DMPK1.72145701
16MAP3K111.70647427
17DAPK31.69116579
18SIK11.66075012
19TAOK21.62415009
20MAP4K11.61880593
21IRAK31.58408235
22MAP3K131.52970396
23MAP2K21.51326014
24ILK1.50623046
25CDC42BPA1.38107394
26KSR21.37884909
27MOS1.35443763
28PRPF4B1.34021280
29DYRK21.30486151
30BCKDK1.25743129
31LIMK11.22387664
32PBK1.19381884
33MARK21.18754690
34DYRK31.15929454
35TESK11.15794921
36IKBKB1.14354599
37PKN21.09325279
38TTN1.07070259
39MYLK1.06941783
40TNK21.05563057
41TYK21.05122627
42TGFBR21.05083804
43FGR1.04462893
44CSK1.04116686
45ADRBK21.03309639
46NME11.03148648
47PTK61.02658687
48ARAF1.01626219
49MAP3K61.00357732
50PDPK11.00235913
51NEK90.99737786
52MATK0.98535142
53STK38L0.96356121
54RPS6KA20.95362462
55LATS10.94253961
56IRAK40.93648573
57BRAF0.90137024
58PHKG10.90001987
59PHKG20.90001987
60MAP3K10.89445377
61IKBKE0.88990858
62STK160.87806529
63MAP3K140.87579643
64IRAK10.86951052
65NLK0.86461611
66CAMK1D0.85544968
67TESK20.84842481
68BMX0.83291202
69DYRK1B0.83129651
70JAK30.82721511
71RPS6KC10.82526125
72RPS6KL10.82526125
73MARK30.82469942
74PRKD20.81668207
75LRRK20.80974436
76MAP3K100.80931544
77GRK70.80550561
78MST40.79534998
79RPS6KA60.78813211
80EPHB10.77870953
81WNK40.77813527
82MUSK0.77536520
83CAMKK20.77469150
84IRAK20.76460676
85KIT0.73102313
86PRKD10.71671711
87MAP2K60.70356493
88SIK20.69500681
89PRKG20.68705444
90ACVR1B0.67126505
91SIK30.67065465
92CDK90.66668372
93HCK0.66083626
94PRKAA20.65718156
95ABL10.64283851
96LYN0.64280724
97TAOK10.62943818
98GRK60.61050662
99BTK0.60501493
100PTK2B0.59962122
101RPS6KA40.59210406
102CSF1R0.58806599
103MAPK120.57260303
104MAP3K50.57082024
105ZAP700.56848503
106PAK10.56328673
107PDK10.56328435
108LMTK20.56218628
109CDK80.55725649
110SYK0.55491095
111MAPK150.54650650
112PAK40.53880685
113STK240.53692470
114ADRBK10.53528197
115MAP2K40.53170989
116GSK3A0.53170293
117ICK0.52925711
118PRKD30.52117882
119CAMK2D0.52091220
120CHUK0.52061385
121STK30.48859765
122PKN10.48680049
123JAK20.47865321
124MAPK70.45065097
125PTK20.45012102
126DAPK20.44660896
127LCK0.43956424
128TXK0.43831501
129ERBB40.40826600
130DDR20.40588071
131RIPK10.40309992
132PAK20.40218218
133MAPK40.40150657
134TIE10.39647137
135STK390.39579911
136HIPK20.39557825
137PRKCD0.39496989
138MAP3K30.39453226
139PIK3CA0.38942555
140MAPK110.38310885
141CDK190.37234872
142STK380.36823374
143FES0.36203125
144PAK60.34318967

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.12486334
2Oxidative phosphorylation_Homo sapiens_hsa001903.96536235
3Sulfur relay system_Homo sapiens_hsa041223.64002047
4Parkinsons disease_Homo sapiens_hsa050123.20013592
5Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.99751067
6Alzheimers disease_Homo sapiens_hsa050102.49009751
7Huntingtons disease_Homo sapiens_hsa050162.30363007
8Staphylococcus aureus infection_Homo sapiens_hsa051502.28975118
9Cardiac muscle contraction_Homo sapiens_hsa042602.16915401
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.13750806
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.02322911
12Pentose and glucuronate interconversions_Homo sapiens_hsa000401.99105646
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.79228177
14Leishmaniasis_Homo sapiens_hsa051401.70960317
15Collecting duct acid secretion_Homo sapiens_hsa049661.68907650
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47494455
17Other glycan degradation_Homo sapiens_hsa005111.43091302
18Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41030936
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.40873007
20Autoimmune thyroid disease_Homo sapiens_hsa053201.40308562
21Malaria_Homo sapiens_hsa051441.40237936
22Fatty acid degradation_Homo sapiens_hsa000711.37046027
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.35676195
24Pertussis_Homo sapiens_hsa051331.34821996
25Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.31921943
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.26400429
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26006185
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.21996146
29Sulfur metabolism_Homo sapiens_hsa009201.21751449
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19080283
31Lysosome_Homo sapiens_hsa041421.17664364
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.16846680
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16752377
34Arachidonic acid metabolism_Homo sapiens_hsa005901.15998377
35Complement and coagulation cascades_Homo sapiens_hsa046101.13895014
36PPAR signaling pathway_Homo sapiens_hsa033201.13382971
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.11077221
38Osteoclast differentiation_Homo sapiens_hsa043801.11038171
39Arginine biosynthesis_Homo sapiens_hsa002201.10965283
40Tuberculosis_Homo sapiens_hsa051521.08239337
41Folate biosynthesis_Homo sapiens_hsa007901.07789883
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07224977
43Linoleic acid metabolism_Homo sapiens_hsa005911.07039424
44Chemokine signaling pathway_Homo sapiens_hsa040621.05621138
45Histidine metabolism_Homo sapiens_hsa003401.04181658
46Primary bile acid biosynthesis_Homo sapiens_hsa001201.03953442
47Vibrio cholerae infection_Homo sapiens_hsa051101.03483750
48Type I diabetes mellitus_Homo sapiens_hsa049401.02259960
49Notch signaling pathway_Homo sapiens_hsa043301.01831924
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00064938
51Antigen processing and presentation_Homo sapiens_hsa046120.99608447
52Hematopoietic cell lineage_Homo sapiens_hsa046400.98896941
53Mineral absorption_Homo sapiens_hsa049780.96654930
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95204183
55Bladder cancer_Homo sapiens_hsa052190.94883206
56Propanoate metabolism_Homo sapiens_hsa006400.94199848
57Tryptophan metabolism_Homo sapiens_hsa003800.92226636
58Chemical carcinogenesis_Homo sapiens_hsa052040.88226582
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87372433
60Peroxisome_Homo sapiens_hsa041460.85922654
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84230657
62Fat digestion and absorption_Homo sapiens_hsa049750.84069431
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83647302
64Rheumatoid arthritis_Homo sapiens_hsa053230.83031261
65Salmonella infection_Homo sapiens_hsa051320.82028665
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81510451
67Arginine and proline metabolism_Homo sapiens_hsa003300.80625812
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77890536
69beta-Alanine metabolism_Homo sapiens_hsa004100.77306884
70African trypanosomiasis_Homo sapiens_hsa051430.76938568
71Glutathione metabolism_Homo sapiens_hsa004800.74663846
72Endocytosis_Homo sapiens_hsa041440.71928304
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71762984
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69732870
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68874847
76Legionellosis_Homo sapiens_hsa051340.68705106
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.68434811
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.67829581
79Graft-versus-host disease_Homo sapiens_hsa053320.67122393
80Renal cell carcinoma_Homo sapiens_hsa052110.65987371
81VEGF signaling pathway_Homo sapiens_hsa043700.65739787
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65538202
83Acute myeloid leukemia_Homo sapiens_hsa052210.63530988
84Carbon metabolism_Homo sapiens_hsa012000.62825220
85Phagosome_Homo sapiens_hsa041450.62254279
86TNF signaling pathway_Homo sapiens_hsa046680.61160689
87Pentose phosphate pathway_Homo sapiens_hsa000300.60606952
88Butanoate metabolism_Homo sapiens_hsa006500.59881049
89Starch and sucrose metabolism_Homo sapiens_hsa005000.59263712
90Retinol metabolism_Homo sapiens_hsa008300.58953336
91Ether lipid metabolism_Homo sapiens_hsa005650.58681786
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57843977
93Viral myocarditis_Homo sapiens_hsa054160.56871000
94Synaptic vesicle cycle_Homo sapiens_hsa047210.56046578
95B cell receptor signaling pathway_Homo sapiens_hsa046620.55189910
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54264463
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.53258353
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.52544453
99Toxoplasmosis_Homo sapiens_hsa051450.51933546
100Shigellosis_Homo sapiens_hsa051310.51242702
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50637124
102Amoebiasis_Homo sapiens_hsa051460.50549256
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50158079
104Allograft rejection_Homo sapiens_hsa053300.49206374
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48678046
106Asthma_Homo sapiens_hsa053100.48666518
107Jak-STAT signaling pathway_Homo sapiens_hsa046300.47344414
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47177898
109Apoptosis_Homo sapiens_hsa042100.46188434
110Prion diseases_Homo sapiens_hsa050200.45375930
111Galactose metabolism_Homo sapiens_hsa000520.43049532
112HIF-1 signaling pathway_Homo sapiens_hsa040660.42879615
113Measles_Homo sapiens_hsa051620.42700766
114Fatty acid metabolism_Homo sapiens_hsa012120.41824687
115Influenza A_Homo sapiens_hsa051640.41768169
116Hepatitis B_Homo sapiens_hsa051610.41230356
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40856381
118Herpes simplex infection_Homo sapiens_hsa051680.40787050
119Sphingolipid metabolism_Homo sapiens_hsa006000.40689263
120Fructose and mannose metabolism_Homo sapiens_hsa000510.40378593
121Steroid hormone biosynthesis_Homo sapiens_hsa001400.39996672
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.39729728
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.36321433
124Phenylalanine metabolism_Homo sapiens_hsa003600.36094298
125Dilated cardiomyopathy_Homo sapiens_hsa054140.35968328
126RNA polymerase_Homo sapiens_hsa030200.35804522
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34334109
128GnRH signaling pathway_Homo sapiens_hsa049120.33858789
129Hepatitis C_Homo sapiens_hsa051600.33845820
130Renin-angiotensin system_Homo sapiens_hsa046140.33027192
131Insulin resistance_Homo sapiens_hsa049310.30138389
132MAPK signaling pathway_Homo sapiens_hsa040100.29945131
133Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29586305
134Drug metabolism - other enzymes_Homo sapiens_hsa009830.29490355
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28222321
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.27874971
137Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24891005
138Prolactin signaling pathway_Homo sapiens_hsa049170.24775693
139T cell receptor signaling pathway_Homo sapiens_hsa046600.24587336
140Platelet activation_Homo sapiens_hsa046110.23988476
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.22407171

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