BRI3BP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.46399537
2vocalization behavior (GO:0071625)5.43330767
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.25734287
4DNA replication checkpoint (GO:0000076)5.20637821
5synaptic vesicle exocytosis (GO:0016079)4.98830074
6DNA strand elongation involved in DNA replication (GO:0006271)4.98431089
7locomotory exploration behavior (GO:0035641)4.95079223
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.94144985
9synaptic vesicle maturation (GO:0016188)4.87325880
10DNA strand elongation (GO:0022616)4.79901714
11glutamate secretion (GO:0014047)4.73043068
12neuron cell-cell adhesion (GO:0007158)4.72391868
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.63907038
14regulation of glutamate receptor signaling pathway (GO:1900449)4.57316450
15protein localization to synapse (GO:0035418)4.45706118
16telomere maintenance via semi-conservative replication (GO:0032201)4.40149338
17positive regulation of synapse maturation (GO:0090129)4.38576963
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.32216965
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.31162332
20DNA replication initiation (GO:0006270)4.26991097
21meiotic chromosome segregation (GO:0045132)4.26806195
22neurotransmitter secretion (GO:0007269)4.22713478
23regulation of synaptic vesicle exocytosis (GO:2000300)4.22135982
24regulation of long-term neuronal synaptic plasticity (GO:0048169)4.19477885
25protein K6-linked ubiquitination (GO:0085020)4.17074735
26neurotransmitter-gated ion channel clustering (GO:0072578)4.11978307
27exploration behavior (GO:0035640)4.09907485
28gamma-aminobutyric acid transport (GO:0015812)4.04464012
29telomere maintenance via recombination (GO:0000722)3.94484632
30glutamate receptor signaling pathway (GO:0007215)3.93566714
31regulation of synaptic vesicle transport (GO:1902803)3.87837167
32nuclear pore complex assembly (GO:0051292)3.87738833
33synaptic transmission, glutamatergic (GO:0035249)3.86986132
34mitotic sister chromatid segregation (GO:0000070)3.85118065
35regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.83724027
36folic acid-containing compound biosynthetic process (GO:0009396)3.80868324
37mitotic recombination (GO:0006312)3.78787442
38mitotic chromosome condensation (GO:0007076)3.78197215
39neuron-neuron synaptic transmission (GO:0007270)3.74996075
40postsynaptic membrane organization (GO:0001941)3.73415483
41G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.71984984
42regulation of neuronal synaptic plasticity (GO:0048168)3.71046107
43neuronal action potential propagation (GO:0019227)3.67786201
44peptidyl-arginine omega-N-methylation (GO:0035247)3.67500690
45sister chromatid segregation (GO:0000819)3.65516207
46nuclear pore organization (GO:0006999)3.60868990
47gamma-aminobutyric acid signaling pathway (GO:0007214)3.60778143
48long-term memory (GO:0007616)3.60038052
49proline transport (GO:0015824)3.59004785
50positive regulation of membrane potential (GO:0045838)3.58147882
51somatic hypermutation of immunoglobulin genes (GO:0016446)3.52557464
52somatic diversification of immune receptors via somatic mutation (GO:0002566)3.52557464
53regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.52022408
54mitotic sister chromatid cohesion (GO:0007064)3.50915788
55ribosomal small subunit biogenesis (GO:0042274)3.39717500
56negative regulation of synaptic transmission, GABAergic (GO:0032229)3.37767487
57protein localization to chromosome, centromeric region (GO:0071459)3.37533643
58peptidyl-arginine methylation (GO:0018216)3.36506714
59peptidyl-arginine N-methylation (GO:0035246)3.36506714
60nucleotide-excision repair, DNA gap filling (GO:0006297)3.31882758
61regulation of excitatory postsynaptic membrane potential (GO:0060079)3.29863719
62response to histamine (GO:0034776)3.28994251
63regulation of DNA endoreduplication (GO:0032875)3.28916792
64neurotransmitter transport (GO:0006836)3.28240344
65regulation of centriole replication (GO:0046599)3.28093464
66positive regulation of dendritic spine morphogenesis (GO:0061003)3.27278003
67replication fork processing (GO:0031297)3.26170888
68maturation of SSU-rRNA (GO:0030490)3.25710367
69regulation of synapse maturation (GO:0090128)3.21735505
70regulation of translational fidelity (GO:0006450)3.21012943
71layer formation in cerebral cortex (GO:0021819)3.19495634
72regulation of centrosome cycle (GO:0046605)3.18920467
73regulation of synapse structural plasticity (GO:0051823)3.18351454
74L-fucose catabolic process (GO:0042355)3.18071772
75fucose catabolic process (GO:0019317)3.18071772
76L-fucose metabolic process (GO:0042354)3.18071772
77pseudouridine synthesis (GO:0001522)3.17203544
78maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.17164586
79negative regulation of microtubule polymerization (GO:0031115)3.15306248
80mitochondrial RNA metabolic process (GO:0000959)3.14190676
81cellular potassium ion homeostasis (GO:0030007)3.13010706
82membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.11856268
83behavioral defense response (GO:0002209)3.09389374
84behavioral fear response (GO:0001662)3.09389374
85regulation of postsynaptic membrane potential (GO:0060078)3.08136787
86regulation of synaptic plasticity (GO:0048167)3.07803365
87nucleobase biosynthetic process (GO:0046112)3.07473213
88pore complex assembly (GO:0046931)3.06766694
89regulation of neurotransmitter levels (GO:0001505)3.05238313
90presynaptic membrane assembly (GO:0097105)3.05027077
91telomere maintenance via telomere lengthening (GO:0010833)3.04727672
92positive regulation of neurotransmitter secretion (GO:0001956)3.04408955
93dendritic spine morphogenesis (GO:0060997)3.01989296
94G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.01798323
95neuron recognition (GO:0008038)3.01374580
96folic acid metabolic process (GO:0046655)2.99001486
97histone arginine methylation (GO:0034969)2.98966719
98DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.95804167
99protein localization to kinetochore (GO:0034501)2.95247689
100double-strand break repair via homologous recombination (GO:0000724)2.94800496
101long-term synaptic potentiation (GO:0060291)2.93519565
102ribosome biogenesis (GO:0042254)2.92917816
103regulation of dendritic spine morphogenesis (GO:0061001)2.92522021
104regulation of centrosome duplication (GO:0010824)2.92477033
105recombinational repair (GO:0000725)2.91553514
106regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.90866595
107positive regulation of neurotransmitter transport (GO:0051590)2.90182749
108sodium ion export (GO:0071436)2.89594878
109DNA replication-dependent nucleosome organization (GO:0034723)2.89437318
110DNA replication-dependent nucleosome assembly (GO:0006335)2.89437318
111positive regulation of mitotic sister chromatid separation (GO:1901970)2.89177734
112positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.89177734
113positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.89177734
114establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.86723523
115mitochondrion transport along microtubule (GO:0047497)2.86723523
116synaptic vesicle endocytosis (GO:0048488)2.86186696
117behavioral response to nicotine (GO:0035095)2.85862992
118transcription from mitochondrial promoter (GO:0006390)2.84848243
119neuromuscular process controlling posture (GO:0050884)2.83914924
120pteridine-containing compound biosynthetic process (GO:0042559)2.82714988
121tetrahydrofolate metabolic process (GO:0046653)2.82428776
122somatic recombination of immunoglobulin gene segments (GO:0016447)2.82076260
123positive regulation of dendritic spine development (GO:0060999)2.81833752
124ribonucleoprotein complex biogenesis (GO:0022613)2.80997432
125DNA duplex unwinding (GO:0032508)2.80954341
126positive regulation of synaptic transmission, GABAergic (GO:0032230)2.80590620
127telomere maintenance (GO:0000723)2.80453177
128water-soluble vitamin biosynthetic process (GO:0042364)2.80244224
129DNA geometric change (GO:0032392)2.80118552
130neuromuscular process controlling balance (GO:0050885)2.78525873
131purine nucleobase biosynthetic process (GO:0009113)2.78261088
132positive regulation of chromosome segregation (GO:0051984)2.77895314
133somatic diversification of immunoglobulins (GO:0016445)2.77786089
134telomere organization (GO:0032200)2.76225064
135transmission of nerve impulse (GO:0019226)2.76184541
136fear response (GO:0042596)2.75624703
137positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.75341278
138cerebellar granule cell differentiation (GO:0021707)2.75139288
139startle response (GO:0001964)2.74852797
140chromatin remodeling at centromere (GO:0031055)2.74776120
141DNA replication (GO:0006260)2.74335464
142histone-serine phosphorylation (GO:0035404)2.74279941
143learning (GO:0007612)2.74238504
144regulation of nuclear cell cycle DNA replication (GO:0033262)2.74142455
145RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.72374105
146regulation of synaptic transmission, glutamatergic (GO:0051966)2.71931833
147maturation of 5.8S rRNA (GO:0000460)2.71812377
148hepatocyte apoptotic process (GO:0097284)2.71609849
149regulation of neurotransmitter secretion (GO:0046928)2.71164529
150social behavior (GO:0035176)2.70845739
151intraspecies interaction between organisms (GO:0051703)2.70845739
152CENP-A containing nucleosome assembly (GO:0034080)2.70236851
153NADH metabolic process (GO:0006734)2.70181909
154cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.70156497
155positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.69835851
156translesion synthesis (GO:0019985)2.69468303
157rRNA processing (GO:0006364)2.68593447
158somatic cell DNA recombination (GO:0016444)2.68027824
159somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.68027824
160DNA deamination (GO:0045006)2.67881527
161activation of protein kinase A activity (GO:0034199)2.67333779
162rRNA metabolic process (GO:0016072)2.66549445
163DNA unwinding involved in DNA replication (GO:0006268)2.66128576
164somatic diversification of immune receptors (GO:0002200)2.66100070
165synapse assembly (GO:0007416)2.65766564
166replicative senescence (GO:0090399)2.65746006
167synaptic transmission (GO:0007268)2.65563959
168presynaptic membrane organization (GO:0097090)2.65288270
169positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.65099981
170mitotic nuclear envelope disassembly (GO:0007077)2.64739090
171auditory behavior (GO:0031223)2.64637594
172positive regulation of synapse assembly (GO:0051965)2.64598369
173V(D)J recombination (GO:0033151)2.64335411
174cerebellum development (GO:0021549)2.63820184
175neuromuscular process (GO:0050905)2.62049084
176regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.61877354
177establishment of mitochondrion localization (GO:0051654)2.61734065
178serotonin metabolic process (GO:0042428)2.59160537
179regulation of mitochondrial translation (GO:0070129)2.58126831
180regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.57823552
181mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.57754656
182somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.57700426
183isotype switching (GO:0045190)2.57700426
184somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.57700426
185DNA conformation change (GO:0071103)2.57659473
186chromosome condensation (GO:0030261)2.56126002
187viral mRNA export from host cell nucleus (GO:0046784)2.55523471
188regulation of translational elongation (GO:0006448)2.55267323
189histone phosphorylation (GO:0016572)2.54736089
190postreplication repair (GO:0006301)2.54211668
191DNA topological change (GO:0006265)2.54052562
192DNA-dependent DNA replication (GO:0006261)2.53466985
193positive regulation of histone H3-K4 methylation (GO:0051571)2.52501094
194DNA recombination (GO:0006310)2.52023753
195negative regulation of DNA-dependent DNA replication (GO:2000104)2.51542208
196folic acid-containing compound metabolic process (GO:0006760)2.49704984
197chromatin assembly (GO:0031497)2.49489409
198mRNA cleavage (GO:0006379)2.49150967
199kinetochore organization (GO:0051383)2.47753778

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.51385436
2E2F7_22180533_ChIP-Seq_HELA_Human4.95616378
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.47640743
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.21502098
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.16175651
6CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.66663644
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.65447876
8AR_21909140_ChIP-Seq_LNCAP_Human2.61942666
9REST_21632747_ChIP-Seq_MESCs_Mouse2.61783244
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.53039700
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.47079356
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.44319234
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.43248753
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.41107232
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.38173451
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.35286270
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.34381151
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.31422599
19GBX2_23144817_ChIP-Seq_PC3_Human2.21394170
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.15051935
21* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.13455825
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.12689654
23* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.11076572
24JARID2_20064375_ChIP-Seq_MESCs_Mouse2.01049026
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.98344265
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.97176584
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.96337666
28MYC_19030024_ChIP-ChIP_MESCs_Mouse1.95226106
29ZNF274_21170338_ChIP-Seq_K562_Hela1.85226507
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.82615391
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.80239927
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.79173295
33* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.77611704
34FOXM1_23109430_ChIP-Seq_U2OS_Human1.74879876
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.70819641
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.66862628
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57226566
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.56166634
39DROSHA_22980978_ChIP-Seq_HELA_Human1.55287218
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.54549869
41SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.51508006
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51081536
43XRN2_22483619_ChIP-Seq_HELA_Human1.50952346
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46591864
45SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.45284191
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.44094933
47ESR1_15608294_ChIP-ChIP_MCF-7_Human1.43332258
48GATA1_22025678_ChIP-Seq_K562_Human1.43159628
49MYC_22102868_ChIP-Seq_BL_Human1.42502397
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.42172678
51CREB1_15753290_ChIP-ChIP_HEK293T_Human1.40935344
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40066864
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39141945
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.39055205
55ELK1_19687146_ChIP-ChIP_HELA_Human1.38695473
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.36812676
57VDR_21846776_ChIP-Seq_THP-1_Human1.36642781
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36406228
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35871531
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35326065
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34457562
62JARID2_20075857_ChIP-Seq_MESCs_Mouse1.33402421
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30071055
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29939615
65TAF15_26573619_Chip-Seq_HEK293_Human1.29342092
66EST1_17652178_ChIP-ChIP_JURKAT_Human1.28951677
67RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.26577974
68RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26205836
69GABP_19822575_ChIP-Seq_HepG2_Human1.25703332
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24949954
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22703731
72SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.22665023
73MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21786777
74EZH2_18974828_ChIP-Seq_MESCs_Mouse1.21540794
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.21540794
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21470646
77TTF2_22483619_ChIP-Seq_HELA_Human1.21097754
78EZH2_27304074_Chip-Seq_ESCs_Mouse1.19424027
79MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17545644
80SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.17012141
81ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15917251
82SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13592917
83CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.13202638
84DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13141210
85IRF1_19129219_ChIP-ChIP_H3396_Human1.12357133
86CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12066175
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11432034
88VDR_22108803_ChIP-Seq_LS180_Human1.10351523
89ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10014145
90IRF8_22096565_ChIP-ChIP_GC-B_Human1.09216770
91POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08042330
92SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.07910007
93FOXP3_21729870_ChIP-Seq_TREG_Human1.07591573
94SRF_21415370_ChIP-Seq_HL-1_Mouse1.07170549
95DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05428511
96* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04879020
97VDR_23849224_ChIP-Seq_CD4+_Human1.04185331
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03010044
99GATA6_25053715_ChIP-Seq_YYC3_Human1.02719389
100RNF2_27304074_Chip-Seq_ESCs_Mouse1.01033468
101EWS_26573619_Chip-Seq_HEK293_Human1.00699314
102TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.00283491
103CIITA_25753668_ChIP-Seq_RAJI_Human1.00106365
104ER_23166858_ChIP-Seq_MCF-7_Human0.99827186
105SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99656466
106CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99578608
107EZH2_27294783_Chip-Seq_ESCs_Mouse0.98022582
108E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97958353
109SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94565842
110PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94415672
111KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.92804862
112ZNF263_19887448_ChIP-Seq_K562_Human0.91246543
113* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90825004
114AR_21572438_ChIP-Seq_LNCaP_Human0.90557966
115NELFA_20434984_ChIP-Seq_ESCs_Mouse0.90451665
116FUS_26573619_Chip-Seq_HEK293_Human0.90027348
117SUZ12_27294783_Chip-Seq_ESCs_Mouse0.89923835
118EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88973448
119SALL1_21062744_ChIP-ChIP_HESCs_Human0.88970511
120CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88928233
121CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88635924
122KDM5A_27292631_Chip-Seq_BREAST_Human0.88405544
123SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88311965
124GABP_17652178_ChIP-ChIP_JURKAT_Human0.88160826
125EGR1_23403033_ChIP-Seq_LIVER_Mouse0.87681743
126FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.87525502
127HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87519972
128ERG_21242973_ChIP-ChIP_JURKAT_Human0.86575954
129DCP1A_22483619_ChIP-Seq_HELA_Human0.85394751
130IGF1R_20145208_ChIP-Seq_DFB_Human0.85302865
131* MYC_18940864_ChIP-ChIP_HL60_Human0.85300710
132EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.83368917
133EED_16625203_ChIP-ChIP_MESCs_Mouse0.82839291
134TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.82435178
135TDRD3_21172665_ChIP-Seq_MCF-7_Human0.81430384
136* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.81405047
137TP63_19390658_ChIP-ChIP_HaCaT_Human0.80908148
138TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.80781827
139ELF5_23300383_ChIP-Seq_T47D_Human0.80699242
140* CHD1_26751641_Chip-Seq_LNCaP_Human0.79669861
141KAP1_22055183_ChIP-Seq_ESCs_Mouse0.79447384
142CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.77410651
143* HOXB7_26014856_ChIP-Seq_BT474_Human0.77193205
144SCL_19346495_ChIP-Seq_HPC-7_Human0.76010963
145CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.75710816
146BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.74102893
147FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.72803038
148FOXA1_25329375_ChIP-Seq_VCAP_Human0.72362142
149FOXA1_27270436_Chip-Seq_PROSTATE_Human0.72362142
150* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72156526
151BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.70556744
152ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.70113004
153P300_27268052_Chip-Seq_Bcells_Human0.68849914

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.31739555
2MP0003880_abnormal_central_pattern4.64868604
3MP0003635_abnormal_synaptic_transmissio4.11203996
4MP0002063_abnormal_learning/memory/cond3.34021708
5MP0009745_abnormal_behavioral_response3.30086172
6MP0009046_muscle_twitch3.25858033
7MP0001968_abnormal_touch/_nociception3.13854916
8MP0010234_abnormal_vibrissa_follicle3.07348926
9MP0002064_seizures3.04595369
10MP0002572_abnormal_emotion/affect_behav2.73807183
11MP0002736_abnormal_nociception_after2.65806765
12MP0002009_preneoplasia2.54930041
13MP0004270_analgesia2.44824523
14MP0002272_abnormal_nervous_system2.33605980
15MP0005423_abnormal_somatic_nervous2.32195993
16MP0001486_abnormal_startle_reflex2.30117627
17MP0003123_paternal_imprinting2.24630144
18MP0002734_abnormal_mechanical_nocicepti2.15983252
19MP0001873_stomach_inflammation2.08536949
20MP0001440_abnormal_grooming_behavior2.03498403
21MP0002735_abnormal_chemical_nociception1.97837410
22MP0009697_abnormal_copulation1.94946687
23MP0001188_hyperpigmentation1.91498197
24MP0002067_abnormal_sensory_capabilities1.91178539
25MP0001501_abnormal_sleep_pattern1.90912823
26MP0003806_abnormal_nucleotide_metabolis1.85069918
27MP0002822_catalepsy1.79676951
28MP0001529_abnormal_vocalization1.75092171
29MP0002160_abnormal_reproductive_system1.74454154
30MP0008569_lethality_at_weaning1.72853721
31MP0002184_abnormal_innervation1.72737821
32MP0002166_altered_tumor_susceptibility1.72512435
33MP0004811_abnormal_neuron_physiology1.70344147
34MP0000427_abnormal_hair_cycle1.67434826
35MP0001984_abnormal_olfaction1.66588395
36MP0001970_abnormal_pain_threshold1.66131798
37MP0003879_abnormal_hair_cell1.65768089
38MP0002733_abnormal_thermal_nociception1.64100532
39MP0004924_abnormal_behavior1.63345150
40MP0005386_behavior/neurological_phenoty1.63345150
41MP0004858_abnormal_nervous_system1.62402436
42MP0004142_abnormal_muscle_tone1.60548321
43MP0002557_abnormal_social/conspecific_i1.60154055
44MP0004264_abnormal_extraembryonic_tissu1.57348580
45MP0000569_abnormal_digit_pigmentation1.57300687
46MP0003111_abnormal_nucleus_morphology1.56428553
47MP0010678_abnormal_skin_adnexa1.55992101
48MP0010094_abnormal_chromosome_stability1.54705703
49MP0004381_abnormal_hair_follicle1.54204322
50MP0003122_maternal_imprinting1.52430523
51MP0003787_abnormal_imprinting1.50243214
52MP0003329_amyloid_beta_deposits1.45554491
53MP0008007_abnormal_cellular_replicative1.39221760
54MP0005360_urolithiasis1.35928683
55MP0004185_abnormal_adipocyte_glucose1.35431936
56MP0000490_abnormal_crypts_of1.34368780
57MP0002006_tumorigenesis1.34045830
58MP0005646_abnormal_pituitary_gland1.33611183
59MP0002066_abnormal_motor_capabilities/c1.33455989
60MP0003763_abnormal_thymus_physiology1.32195800
61MP0002098_abnormal_vibrissa_morphology1.31832456
62MP0003718_maternal_effect1.31781895
63MP0006276_abnormal_autonomic_nervous1.31698081
64MP0005645_abnormal_hypothalamus_physiol1.31383248
65MP0002163_abnormal_gland_morphology1.29662032
66MP0000778_abnormal_nervous_system1.29422327
67MP0003786_premature_aging1.28559393
68MP0005075_abnormal_melanosome_morpholog1.28354201
69MP0003121_genomic_imprinting1.27908718
70MP0002796_impaired_skin_barrier1.26681953
71MP0000383_abnormal_hair_follicle1.25935901
72MP0005389_reproductive_system_phenotype1.25809562
73MP0003646_muscle_fatigue1.25733250
74MP0005220_abnormal_exocrine_pancreas1.25725551
75MP0010307_abnormal_tumor_latency1.25443544
76MP0000955_abnormal_spinal_cord1.23942511
77MP0008872_abnormal_physiological_respon1.23193078
78MP0008877_abnormal_DNA_methylation1.21759740
79MP0001919_abnormal_reproductive_system1.21735424
80MP0006035_abnormal_mitochondrial_morpho1.20893598
81MP0003183_abnormal_peptide_metabolism1.20873677
82MP0002882_abnormal_neuron_morphology1.20261038
83MP0001664_abnormal_digestion1.19662999
84MP0003693_abnormal_embryo_hatching1.18782029
85MP0002152_abnormal_brain_morphology1.18630313
86MP0005499_abnormal_olfactory_system1.16872440
87MP0005394_taste/olfaction_phenotype1.16872440
88MP0001905_abnormal_dopamine_level1.15737036
89MP0001666_abnormal_nutrient_absorption1.14978276
90MP0000015_abnormal_ear_pigmentation1.13767127
91MP0000350_abnormal_cell_proliferation1.13719946
92MP0005501_abnormal_skin_physiology1.13424799
93MP0002876_abnormal_thyroid_physiology1.13321432
94MP0001986_abnormal_taste_sensitivity1.13165892
95MP0002693_abnormal_pancreas_physiology1.13160253
96MP0004957_abnormal_blastocyst_morpholog1.13122775
97MP0002877_abnormal_melanocyte_morpholog1.11799680
98MP0008875_abnormal_xenobiotic_pharmacok1.10535142
99MP0005379_endocrine/exocrine_gland_phen1.08838275
100MP0002396_abnormal_hematopoietic_system1.07028423
101MP0004782_abnormal_surfactant_physiolog1.06081120
102MP0008932_abnormal_embryonic_tissue1.05497426
103MP0003303_peritoneal_inflammation1.04814177
104MP0002909_abnormal_adrenal_gland1.03741938
105MP0004215_abnormal_myocardial_fiber1.01612658
106MP0000470_abnormal_stomach_morphology0.98520606
107MP0002102_abnormal_ear_morphology0.98131808
108MP0001765_abnormal_ion_homeostasis0.97530689
109MP0009379_abnormal_foot_pigmentation0.97086519
110MP0001944_abnormal_pancreas_morphology0.95189121
111MP0004233_abnormal_muscle_weight0.94417066
112MP0002019_abnormal_tumor_incidence0.94103516
113MP0003866_abnormal_defecation0.93867787
114MP0005332_abnormal_amino_acid0.93712321
115MP0001800_abnormal_humoral_immune0.93452106
116MP0004742_abnormal_vestibular_system0.93385198
117MP0005310_abnormal_salivary_gland0.91639852
118MP0006292_abnormal_olfactory_placode0.91302726
119MP0005174_abnormal_tail_pigmentation0.89546996
120MP0004147_increased_porphyrin_level0.88830783
121MP0000685_abnormal_immune_system0.87940730
122MP0001835_abnormal_antigen_presentation0.86845432
123MP0003077_abnormal_cell_cycle0.86102452
124MP0001346_abnormal_lacrimal_gland0.84848581
125MP0003943_abnormal_hepatobiliary_system0.84148334
126MP0000313_abnormal_cell_death0.84108211
127MP0000631_abnormal_neuroendocrine_gland0.84075285
128MP0000703_abnormal_thymus_morphology0.83728386
129MP0001929_abnormal_gametogenesis0.83124031
130MP0001661_extended_life_span0.82994694
131MP0002210_abnormal_sex_determination0.82946898
132MP0000751_myopathy0.82628458
133MP0003137_abnormal_impulse_conducting0.82341151
134MP0005409_darkened_coat_color0.82132529
135MP0005076_abnormal_cell_differentiation0.80237334
136MP0004043_abnormal_pH_regulation0.79492317
137MP0001730_embryonic_growth_arrest0.79407694
138MP0003861_abnormal_nervous_system0.79288787
139MP0002970_abnormal_white_adipose0.78211183
140MP0002398_abnormal_bone_marrow0.77931803
141MP0003315_abnormal_perineum_morphology0.77117982
142MP0002234_abnormal_pharynx_morphology0.76378351
143MP0008874_decreased_physiological_sensi0.76346798
144MP0001764_abnormal_homeostasis0.76326063
145MP0004808_abnormal_hematopoietic_stem0.76189890
146MP0000377_abnormal_hair_follicle0.75760095
147MP0004484_altered_response_of0.75497616
148MP0001697_abnormal_embryo_size0.75403929
149MP0008058_abnormal_DNA_repair0.73456697
150MP0001502_abnormal_circadian_rhythm0.72086340
151MP0001145_abnormal_male_reproductive0.72000923
152MP0000678_abnormal_parathyroid_gland0.71769733
153MP0008057_abnormal_DNA_replication0.71675821
154MP0002069_abnormal_eating/drinking_beha0.71150146
155MP0002095_abnormal_skin_pigmentation0.71111734
156MP0005085_abnormal_gallbladder_physiolo0.71101023
157MP0001881_abnormal_mammary_gland0.70651349
158MP0002089_abnormal_postnatal_growth/wei0.70541191
159MP0000689_abnormal_spleen_morphology0.70244729
160MP0003631_nervous_system_phenotype0.69938367
161MP0003633_abnormal_nervous_system0.69657832
162MP0001963_abnormal_hearing_physiology0.69651823
163MP0004885_abnormal_endolymph0.69572225
164MP0002229_neurodegeneration0.68218975
165MP0001485_abnormal_pinna_reflex0.67261963
166MP0010769_abnormal_survival0.67254580
167MP0003938_abnormal_ear_development0.66579919
168MP0010768_mortality/aging0.65767218
169MP0003119_abnormal_digestive_system0.63651895
170MP0002082_postnatal_lethality0.63563423
171MP0010770_preweaning_lethality0.63563423
172MP0006036_abnormal_mitochondrial_physio0.62521271
173MP0004085_abnormal_heartbeat0.59492417
174MP0003956_abnormal_body_size0.57032255
175MP0008789_abnormal_olfactory_epithelium0.56321026
176MP0002752_abnormal_somatic_nervous0.56078700

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.82170553
2Visual hallucinations (HP:0002367)5.01838032
3Myokymia (HP:0002411)5.01547979
4Focal seizures (HP:0007359)4.87760979
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.71981400
6Chromsome breakage (HP:0040012)4.53111883
7Epileptic encephalopathy (HP:0200134)4.49919498
8Atonic seizures (HP:0010819)4.48346190
9Febrile seizures (HP:0002373)4.42501035
10Absence seizures (HP:0002121)3.99769751
11Poor eye contact (HP:0000817)3.75952055
12Progressive cerebellar ataxia (HP:0002073)3.60876797
13Dialeptic seizures (HP:0011146)3.60295250
14Broad-based gait (HP:0002136)3.52010900
15Impaired social interactions (HP:0000735)3.35826544
16Abnormal social behavior (HP:0012433)3.35826544
17Abnormality of the preputium (HP:0100587)3.31161140
18Generalized tonic-clonic seizures (HP:0002069)3.25327037
19Aplasia/Hypoplasia of the uvula (HP:0010293)3.14317519
20Papilledema (HP:0001085)3.13972241
21Abnormality of chromosome stability (HP:0003220)3.11675714
22Hyperventilation (HP:0002883)3.09726079
23Impaired vibration sensation in the lower limbs (HP:0002166)2.84007888
24Mutism (HP:0002300)2.83152537
25Clubbing of toes (HP:0100760)2.80430447
26Meckel diverticulum (HP:0002245)2.79092929
27Depression (HP:0000716)2.78818524
28Impaired smooth pursuit (HP:0007772)2.78806861
29Abnormality of the labia minora (HP:0012880)2.75283962
30Abnormality of the ileum (HP:0001549)2.73936458
31Urinary urgency (HP:0000012)2.72536597
32B lymphocytopenia (HP:0010976)2.70657621
33Unsteady gait (HP:0002317)2.70577786
34Truncal ataxia (HP:0002078)2.69301378
35Dysdiadochokinesis (HP:0002075)2.69277205
36Progressive inability to walk (HP:0002505)2.67473984
37Amyotrophic lateral sclerosis (HP:0007354)2.67432197
38Gaze-evoked nystagmus (HP:0000640)2.66677446
39Abnormality of B cell number (HP:0010975)2.62936412
40Drooling (HP:0002307)2.61508592
41Excessive salivation (HP:0003781)2.61508592
42Inability to walk (HP:0002540)2.60867080
43Genetic anticipation (HP:0003743)2.59824493
44Limb hypertonia (HP:0002509)2.58198125
45Septate vagina (HP:0001153)2.57004724
46Abnormality of the carotid arteries (HP:0005344)2.52847205
47Absent thumb (HP:0009777)2.50928471
48Abnormal eating behavior (HP:0100738)2.49161656
49Urinary bladder sphincter dysfunction (HP:0002839)2.48885808
50Abnormality of the lower motor neuron (HP:0002366)2.48199672
51Poor suck (HP:0002033)2.45749392
52Patellar aplasia (HP:0006443)2.42676441
53Aplasia/Hypoplasia of the patella (HP:0006498)2.41268292
54Hypoplasia of the pons (HP:0012110)2.40957424
55Delusions (HP:0000746)2.39517088
56Diplopia (HP:0000651)2.39151772
57Abnormality of binocular vision (HP:0011514)2.39151772
58Type II lissencephaly (HP:0007260)2.37573384
59Abnormality of ocular smooth pursuit (HP:0000617)2.36822412
60Pili torti (HP:0003777)2.36352435
61Agammaglobulinemia (HP:0004432)2.35621021
62Epileptiform EEG discharges (HP:0011182)2.34779796
63Abnormal number of erythroid precursors (HP:0012131)2.31238489
64Status epilepticus (HP:0002133)2.29912735
65Abnormality of the pons (HP:0007361)2.28114042
66Abnormality of alanine metabolism (HP:0010916)2.26848918
67Hyperalaninemia (HP:0003348)2.26848918
68Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26848918
69Cerebral hypomyelination (HP:0006808)2.26226972
70Duodenal stenosis (HP:0100867)2.25945629
71Small intestinal stenosis (HP:0012848)2.25945629
72Duplicated collecting system (HP:0000081)2.25333336
73Abnormality of the renal collecting system (HP:0004742)2.24198959
74Pointed chin (HP:0000307)2.22852548
75EEG with generalized epileptiform discharges (HP:0011198)2.19622117
76Bradykinesia (HP:0002067)2.19325986
77Reticulocytopenia (HP:0001896)2.18194263
78Progressive microcephaly (HP:0000253)2.18032040
79Protruding tongue (HP:0010808)2.18011113
80Annular pancreas (HP:0001734)2.17350094
81Polyphagia (HP:0002591)2.17335905
82Abnormality of cells of the erythroid lineage (HP:0012130)2.16834622
83Action tremor (HP:0002345)2.13501813
84Acute lymphatic leukemia (HP:0006721)2.13036221
85Lipid accumulation in hepatocytes (HP:0006561)2.12374030
86Hypsarrhythmia (HP:0002521)2.11934735
87Conjunctival hamartoma (HP:0100780)2.11850915
88Ketoacidosis (HP:0001993)2.11529481
89Fetal akinesia sequence (HP:0001989)2.10317112
90Squamous cell carcinoma (HP:0002860)2.10107942
91Neoplasm of the peripheral nervous system (HP:0100007)2.09309280
92Poikiloderma (HP:0001029)2.08670466
93Asymmetry of the thorax (HP:0001555)2.08204305
94Anxiety (HP:0000739)2.06961301
95Insomnia (HP:0100785)2.06133529
96Birth length less than 3rd percentile (HP:0003561)2.05827138
97Dysmetria (HP:0001310)2.05510259
98Amblyopia (HP:0000646)2.04517965
99Scanning speech (HP:0002168)2.03531143
100Ankle clonus (HP:0011448)2.03136959
101Obstructive sleep apnea (HP:0002870)2.02166809
102Abnormality of DNA repair (HP:0003254)2.01435119
103Ragged-red muscle fibers (HP:0003200)2.00378091
104Dysmetric saccades (HP:0000641)2.00280633
105Inappropriate behavior (HP:0000719)2.00090143
106Microretrognathia (HP:0000308)1.98774552
107Microvesicular hepatic steatosis (HP:0001414)1.98652194
108Stereotypic behavior (HP:0000733)1.96139752
109Abnormal hair laboratory examination (HP:0003328)1.95956009
110Postural instability (HP:0002172)1.95803096
111Myelodysplasia (HP:0002863)1.94978102
112Hypothermia (HP:0002045)1.94276925
113Sleep apnea (HP:0010535)1.93222715
114Sloping forehead (HP:0000340)1.92600294
115Horizontal nystagmus (HP:0000666)1.92224062
116Abnormal hair whorl (HP:0010721)1.92052425
117Congenital stationary night blindness (HP:0007642)1.90903108
118Postnatal microcephaly (HP:0005484)1.90769925
119Cerebellar dysplasia (HP:0007033)1.90721841
120Pendular nystagmus (HP:0012043)1.88524722
121Severe global developmental delay (HP:0011344)1.87374843
122Hemiplegia (HP:0002301)1.87235117
123Decreased circulating renin level (HP:0003351)1.85439322
124Ketosis (HP:0001946)1.85323907
125Unilateral renal agenesis (HP:0000122)1.85286331
126Atrophy/Degeneration involving motor neurons (HP:0007373)1.85073810
127Panhypogammaglobulinemia (HP:0003139)1.84554762
128Congenital, generalized hypertrichosis (HP:0004540)1.84129238
129Spastic gait (HP:0002064)1.83858796
130Retinal dysplasia (HP:0007973)1.83851603
131Short thumb (HP:0009778)1.83522912
132Renal cortical cysts (HP:0000803)1.82978276
133Emotional lability (HP:0000712)1.82736578
134Generalized hypotonia (HP:0001290)1.80421347
135Impaired vibratory sensation (HP:0002495)1.80182983
136Cafe-au-lait spot (HP:0000957)1.79223862
137Generalized myoclonic seizures (HP:0002123)1.78981411
138Concave nail (HP:0001598)1.76946553
139Lissencephaly (HP:0001339)1.75800167
140Ventricular fibrillation (HP:0001663)1.75538147
141Deep palmar crease (HP:0006191)1.74109791
142Sacral dimple (HP:0000960)1.73769352
143Partial agenesis of the corpus callosum (HP:0001338)1.73193355
144Breast hypoplasia (HP:0003187)1.72736558
145Macrocytic anemia (HP:0001972)1.71931702
146Increased serum lactate (HP:0002151)1.71807853
147Supranuclear gaze palsy (HP:0000605)1.71384824
148Aplastic anemia (HP:0001915)1.69936639
149Abnormality of the duodenum (HP:0002246)1.69609287
150Abnormality of T cell physiology (HP:0011840)1.68120945
151Pallor (HP:0000980)1.67926619
152Increased hepatocellular lipid droplets (HP:0006565)1.67875540
15311 pairs of ribs (HP:0000878)1.67785884
154Megaloblastic anemia (HP:0001889)1.67039725
155CNS hypomyelination (HP:0003429)1.66627928
156Sensory axonal neuropathy (HP:0003390)1.66589291
157Prostate neoplasm (HP:0100787)1.65434177
158Hemiparesis (HP:0001269)1.64960452
159Aplasia/Hypoplasia of the sacrum (HP:0008517)1.64761423
160Oral leukoplakia (HP:0002745)1.63758547
161Iris hypopigmentation (HP:0007730)1.63563106
162Abnormality of the renal cortex (HP:0011035)1.63243192
163Increased serum pyruvate (HP:0003542)1.63184005
164Abnormality of glycolysis (HP:0004366)1.63184005
165Hyperglycinuria (HP:0003108)1.62093813
166Hamartoma of the eye (HP:0010568)1.61920316
167Alkalosis (HP:0001948)1.61707305
168Neoplasm of the adrenal cortex (HP:0100641)1.61093931
169Large for gestational age (HP:0001520)1.58827557
170Abnormality of vitamin B metabolism (HP:0004340)1.57034355
171Breast carcinoma (HP:0003002)1.54991774
172Lethargy (HP:0001254)1.54825389
173Abnormality of the vitamin B12 metabolism (HP:0004341)1.53781950
174Pancytopenia (HP:0001876)1.53135495
175Abnormality of chromosome segregation (HP:0002916)1.53081906
176Abnormality of cochlea (HP:0000375)1.52944037
177Metabolic alkalosis (HP:0200114)1.52690936
178Hypoglycemic coma (HP:0001325)1.51989853
179Tinnitus (HP:0000360)1.51407261
180Homocystinuria (HP:0002156)1.51277301
181Abnormality of homocysteine metabolism (HP:0010919)1.51277301
182Bone marrow hypocellularity (HP:0005528)1.50664931
183Hypobetalipoproteinemia (HP:0003563)1.50496459
184Villous atrophy (HP:0011473)1.50081458
185Abnormality of small intestinal villus morphology (HP:0011472)1.50081458
186Arteriovenous malformation (HP:0100026)1.49789960
187Clumsiness (HP:0002312)1.48576712
188Multiple enchondromatosis (HP:0005701)1.47366025
189Increased CSF lactate (HP:0002490)1.46800382
190Fibular aplasia (HP:0002990)1.45956473

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.68349760
2MARK13.28331902
3MINK12.80482006
4MAP3K122.76528256
5EPHA42.76463691
6MAP3K42.74371880
7MAP3K92.66890893
8FRK2.64402276
9RPS6KB22.59610690
10ZAK2.58453991
11MAP2K72.52645003
12CDK192.33721391
13CASK2.33269701
14DAPK12.32820763
15SCYL22.32745304
16ACVR1B2.17623861
17EIF2AK32.13889954
18SMG12.11300656
19STK391.98621721
20TAF11.95548766
21NTRK21.85191415
22FES1.82705241
23TSSK61.76231880
24TNIK1.76035840
25TTK1.72309849
26KSR11.71415528
27PAK61.70021082
28MAP3K101.68413790
29MST1R1.64296598
30BRSK21.63685365
31MAPK131.62500374
32NEK11.61432634
33TRIB31.59725618
34WEE11.59258564
35MAP2K41.58849035
36CDC71.54409961
37BUB11.54223772
38WNK41.51972413
39DAPK21.51390682
40OXSR11.43881629
41PLK21.42548290
42VRK21.41592231
43STK161.39967240
44ALK1.38845923
45CCNB11.38107373
46CAMKK11.37888195
47KSR21.32223527
48PRKD31.29936966
49RIPK41.29871520
50NUAK11.29033383
51BMPR1B1.24867259
52PNCK1.24844557
53RAF11.20592056
54MST41.18331376
55CDK121.17824619
56SIK21.16582009
57MAPKAPK51.15762416
58CDK41.15522089
59EIF2AK21.13498367
60NME11.13497270
61PRKCG1.11380907
62EIF2AK11.11176548
63CDK51.10030767
64LATS21.08613751
65CDK71.08162100
66AURKB1.06935303
67MAP2K21.05989217
68PRKCI1.05242655
69PASK1.03874499
70BMPR21.01422893
71MAPK110.99933615
72PLK40.97783026
73PIK3CA0.97745148
74CDK180.94093197
75EEF2K0.93739971
76UHMK10.93683942
77TAOK20.92856538
78CDK150.92132005
79GRK10.91349565
80CDK80.90962420
81PRPF4B0.89868569
82MAPKAPK30.89617882
83BRSK10.89558814
84TLK10.88142718
85CDK140.86472082
86PLK30.85980204
87MAP3K130.85335314
88MKNK20.84646365
89MELK0.83861291
90PKN20.83753291
91CDK11A0.83481186
92PBK0.81281720
93GRK50.79585882
94MAP3K60.79545422
95STK110.78410537
96CHEK10.77752303
97ATM0.75945205
98INSRR0.74349855
99MAP3K50.74153675
100AKT30.73918380
101VRK10.73715230
102GRK60.73224286
103NME20.72072034
104EPHA20.71687856
105NEK20.71202384
106RPS6KA40.71175266
107CAMK10.70326990
108BRAF0.69095376
109MAP3K140.68183768
110SYK0.65729743
111ADRBK20.64881322
112STK380.63286801
113ARAF0.63142795
114RPS6KA50.61131837
115CAMKK20.60405647
116PLK10.59667569
117CSF1R0.58985574
118CAMK2A0.58841128
119PIM20.58076445
120DAPK30.57021948
121SRPK10.56721385
122DYRK1A0.56639233
123PHKG20.54720947
124PHKG10.54720947
125MAP4K10.54572260
126CDK10.53882850
127AURKA0.53090258
128CSNK1G20.53030601
129RPS6KB10.52623424
130TESK20.51957218
131MKNK10.51709726
132MAP3K80.47428557
133PDK10.46396909
134CDK30.45584097
135PDK30.45192697
136PDK40.45192697
137STK30.44450872
138MAP2K10.44301678
139TAOK30.44274905
140PINK10.43098495
141PRKCQ0.42033918
142CSNK1E0.40921900
143ATR0.39659076
144BTK0.38799556
145CDK20.37440531
146RPS6KA30.37046221
147STK40.36801011
148CAMK2B0.36648196
149NTRK10.36373092
150BRD40.34978355
151AKT20.34251940
152MAP2K60.33629128
153TNK20.32394695
154TAOK10.32195966
155CHEK20.32152192
156RPS6KA20.29192843
157PRKCB0.28459400
158CSNK2A20.27486715

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.23283804
2Synaptic vesicle cycle_Homo sapiens_hsa047213.07197934
3Fanconi anemia pathway_Homo sapiens_hsa034602.82127486
4Long-term potentiation_Homo sapiens_hsa047202.74930891
5Olfactory transduction_Homo sapiens_hsa047402.59208076
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.52976649
7GABAergic synapse_Homo sapiens_hsa047272.48270086
8Circadian entrainment_Homo sapiens_hsa047132.40243948
9Morphine addiction_Homo sapiens_hsa050322.39339023
10Non-homologous end-joining_Homo sapiens_hsa034502.38730050
11Glutamatergic synapse_Homo sapiens_hsa047242.28828843
12DNA replication_Homo sapiens_hsa030302.20120211
13Amphetamine addiction_Homo sapiens_hsa050312.05679620
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.04972448
15Selenocompound metabolism_Homo sapiens_hsa004502.03384641
16Dopaminergic synapse_Homo sapiens_hsa047281.95944660
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.73794431
18Salivary secretion_Homo sapiens_hsa049701.68582469
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.64515192
20Systemic lupus erythematosus_Homo sapiens_hsa053221.60196453
21Long-term depression_Homo sapiens_hsa047301.55376686
22Oocyte meiosis_Homo sapiens_hsa041141.52977830
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.45117219
24Taste transduction_Homo sapiens_hsa047421.44053037
25Cholinergic synapse_Homo sapiens_hsa047251.42023393
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.38872009
27RNA degradation_Homo sapiens_hsa030181.38472659
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37676445
29Caffeine metabolism_Homo sapiens_hsa002321.36340948
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.35096141
31Calcium signaling pathway_Homo sapiens_hsa040201.34814415
32Insulin secretion_Homo sapiens_hsa049111.34599290
33Primary immunodeficiency_Homo sapiens_hsa053401.33206193
34RNA polymerase_Homo sapiens_hsa030201.32950115
35Mismatch repair_Homo sapiens_hsa034301.31343884
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.30502855
37Gastric acid secretion_Homo sapiens_hsa049711.30218164
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.28442827
39Glioma_Homo sapiens_hsa052141.26426310
40Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.26209057
41Vitamin digestion and absorption_Homo sapiens_hsa049771.24575283
42Basal transcription factors_Homo sapiens_hsa030221.23314275
43Serotonergic synapse_Homo sapiens_hsa047261.22385482
44RNA transport_Homo sapiens_hsa030131.22346037
45Gap junction_Homo sapiens_hsa045401.21375381
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18980088
47Ribosome_Homo sapiens_hsa030101.18581976
48Tryptophan metabolism_Homo sapiens_hsa003801.17911846
49Oxytocin signaling pathway_Homo sapiens_hsa049211.16847971
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15259089
51Pentose and glucuronate interconversions_Homo sapiens_hsa000401.12554519
52B cell receptor signaling pathway_Homo sapiens_hsa046621.12212500
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11640586
54Asthma_Homo sapiens_hsa053101.08959632
55GnRH signaling pathway_Homo sapiens_hsa049121.08302810
56Spliceosome_Homo sapiens_hsa030401.07908052
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07825145
58Base excision repair_Homo sapiens_hsa034101.04624496
59Drug metabolism - other enzymes_Homo sapiens_hsa009831.03914353
60Vitamin B6 metabolism_Homo sapiens_hsa007501.03517516
61Collecting duct acid secretion_Homo sapiens_hsa049661.03174238
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01312313
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01141239
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97853890
65Linoleic acid metabolism_Homo sapiens_hsa005910.97037047
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96215363
67Estrogen signaling pathway_Homo sapiens_hsa049150.95968259
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95465735
69Pyrimidine metabolism_Homo sapiens_hsa002400.95400002
70Cardiac muscle contraction_Homo sapiens_hsa042600.95362937
71Ether lipid metabolism_Homo sapiens_hsa005650.94882961
72Alcoholism_Homo sapiens_hsa050340.94500320
73Sulfur relay system_Homo sapiens_hsa041220.92528231
74Fat digestion and absorption_Homo sapiens_hsa049750.91582488
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91027907
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.90850021
77Nucleotide excision repair_Homo sapiens_hsa034200.89763059
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89679729
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87672060
80ErbB signaling pathway_Homo sapiens_hsa040120.87498189
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86859926
82Cocaine addiction_Homo sapiens_hsa050300.86660747
83cAMP signaling pathway_Homo sapiens_hsa040240.86283747
84Biosynthesis of amino acids_Homo sapiens_hsa012300.84283340
85Renin secretion_Homo sapiens_hsa049240.80414272
86Histidine metabolism_Homo sapiens_hsa003400.79938850
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.79139908
88Parkinsons disease_Homo sapiens_hsa050120.76778378
89mRNA surveillance pathway_Homo sapiens_hsa030150.76374674
90Melanogenesis_Homo sapiens_hsa049160.76333092
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76327468
92Phototransduction_Homo sapiens_hsa047440.76003835
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74726833
94Butanoate metabolism_Homo sapiens_hsa006500.72890008
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71828469
96Cell cycle_Homo sapiens_hsa041100.71611588
97Purine metabolism_Homo sapiens_hsa002300.70196431
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.69072635
99Non-small cell lung cancer_Homo sapiens_hsa052230.68966849
100Huntingtons disease_Homo sapiens_hsa050160.68521618
101Proteasome_Homo sapiens_hsa030500.68240979
102Nitrogen metabolism_Homo sapiens_hsa009100.68068416
103Oxidative phosphorylation_Homo sapiens_hsa001900.66944365
104Sulfur metabolism_Homo sapiens_hsa009200.66083321
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65755282
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.65674181
107Homologous recombination_Homo sapiens_hsa034400.64900095
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64364921
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64124225
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62800661
111Vibrio cholerae infection_Homo sapiens_hsa051100.62738075
112Alzheimers disease_Homo sapiens_hsa050100.60773680
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.60237348
114Endometrial cancer_Homo sapiens_hsa052130.60039848
115Sphingolipid metabolism_Homo sapiens_hsa006000.59747721
116Renin-angiotensin system_Homo sapiens_hsa046140.58764256
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57917853
118Type II diabetes mellitus_Homo sapiens_hsa049300.56360056
119One carbon pool by folate_Homo sapiens_hsa006700.55867256
120Colorectal cancer_Homo sapiens_hsa052100.54874986
121Protein export_Homo sapiens_hsa030600.54182455
122Cyanoamino acid metabolism_Homo sapiens_hsa004600.53937760
123Carbon metabolism_Homo sapiens_hsa012000.53090214
124Folate biosynthesis_Homo sapiens_hsa007900.51301355
125mTOR signaling pathway_Homo sapiens_hsa041500.51053150
126Mineral absorption_Homo sapiens_hsa049780.51051199
127Thyroid cancer_Homo sapiens_hsa052160.49809223
128Type I diabetes mellitus_Homo sapiens_hsa049400.48852387
129Phenylalanine metabolism_Homo sapiens_hsa003600.48407851
130ABC transporters_Homo sapiens_hsa020100.48233475
131Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47116432
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46421732
133p53 signaling pathway_Homo sapiens_hsa041150.46315176
134Arginine biosynthesis_Homo sapiens_hsa002200.46295857
135Glucagon signaling pathway_Homo sapiens_hsa049220.46130127
136Metabolic pathways_Homo sapiens_hsa011000.45281506
137Retinol metabolism_Homo sapiens_hsa008300.43359847
138Inositol phosphate metabolism_Homo sapiens_hsa005620.42692557
139Chemical carcinogenesis_Homo sapiens_hsa052040.41659544
140Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41157727
141Insulin signaling pathway_Homo sapiens_hsa049100.40537476
142Phospholipase D signaling pathway_Homo sapiens_hsa040720.40140527
143MAPK signaling pathway_Homo sapiens_hsa040100.38953088
144Axon guidance_Homo sapiens_hsa043600.38694699
145N-Glycan biosynthesis_Homo sapiens_hsa005100.38465391
146HIF-1 signaling pathway_Homo sapiens_hsa040660.38021967
147Lysine degradation_Homo sapiens_hsa003100.37344943
148Glycerolipid metabolism_Homo sapiens_hsa005610.37095650
149Choline metabolism in cancer_Homo sapiens_hsa052310.36413545
150Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35502517
151Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34260431
152Viral carcinogenesis_Homo sapiens_hsa052030.32653373
153Fatty acid biosynthesis_Homo sapiens_hsa000610.32413319
154Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30941712
155Pyruvate metabolism_Homo sapiens_hsa006200.27122526
156Epstein-Barr virus infection_Homo sapiens_hsa051690.26594453
157Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.24953279
158Allograft rejection_Homo sapiens_hsa053300.24007264
159Glycerophospholipid metabolism_Homo sapiens_hsa005640.23222842
160Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.22738811
161Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.21915889
162Autoimmune thyroid disease_Homo sapiens_hsa053200.21563816

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