ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein K11-linked deubiquitination (GO:0035871)	5.32889694
2	neural tube formation (GO:0001841)	4.70044195
3	synapsis (GO:0007129)	4.33031555
4	regulation of memory T cell differentiation (GO:0043380)	4.25650071
5	resolution of meiotic recombination intermediates (GO:0000712)	3.87993700
6	V(D)J recombination (GO:0033151)	3.87093586
7	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.75151829
8	sex differentiation (GO:0007548)	3.74243089
9	seminiferous tubule development (GO:0072520)	3.62983545
10	regulation of MHC class I biosynthetic process (GO:0045343)	3.55267346
11	piRNA metabolic process (GO:0034587)	3.53570064
12	negative regulation of thymocyte apoptotic process (GO:0070244)	3.51117358
13	negative regulation of mast cell activation (GO:0033004)	3.45189480
14	auditory receptor cell stereocilium organization (GO:0060088)	3.44106983
15	reciprocal meiotic recombination (GO:0007131)	3.42230498
16	reciprocal DNA recombination (GO:0035825)	3.42230498
17	regulation of establishment of cell polarity (GO:2000114)	3.41686799
18	male meiosis I (GO:0007141)	3.36099450
19	serotonin receptor signaling pathway (GO:0007210)	3.35904314
20	replication fork processing (GO:0031297)	3.35885443
21	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.35496646
22	cellular response to ethanol (GO:0071361)	3.32290626
23	mannosylation (GO:0097502)	3.29669634
24	cytoplasmic mRNA processing body assembly (GO:0033962)	3.28912141
25	indole-containing compound catabolic process (GO:0042436)	3.28557008
26	indolalkylamine catabolic process (GO:0046218)	3.28557008
27	tryptophan catabolic process (GO:0006569)	3.28557008
28	regulation of DNA endoreduplication (GO:0032875)	3.27245511
29	intra-S DNA damage checkpoint (GO:0031573)	3.27153765
30	protein-cofactor linkage (GO:0018065)	3.26052500
31	protein localization to cilium (GO:0061512)	3.23176928
32	somatic diversification of immune receptors (GO:0002200)	3.20179393
33	recombinational repair (GO:0000725)	3.17041043
34	cellular ketone body metabolic process (GO:0046950)	3.15042033
35	double-strand break repair via homologous recombination (GO:0000724)	3.13849495
36	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.13539357
37	regulation of thymocyte apoptotic process (GO:0070243)	3.13512372
38	DNA methylation involved in gamete generation (GO:0043046)	3.11887541
39	neuron fate determination (GO:0048664)	3.11376020
40	DNA double-strand break processing (GO:0000729)	3.09042812
41	kinetochore assembly (GO:0051382)	3.07678926
42	somite rostral/caudal axis specification (GO:0032525)	3.05270021
43	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	3.03494265
44	cytochrome complex assembly (GO:0017004)	3.00009811
45	acrosome assembly (GO:0001675)	2.99423552
46	negative regulation of multicellular organism growth (GO:0040015)	2.98904837
47	regulation of meiosis I (GO:0060631)	2.96999025
48	kynurenine metabolic process (GO:0070189)	2.95866576
49	respiratory chain complex IV assembly (GO:0008535)	2.93770145
50	chromosome organization involved in meiosis (GO:0070192)	2.91391954
51	establishment of protein localization to Golgi (GO:0072600)	2.88002446
52	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.84807289
53	kidney morphogenesis (GO:0060993)	2.83757030
54	detection of light stimulus involved in visual perception (GO:0050908)	2.82663306
55	detection of light stimulus involved in sensory perception (GO:0050962)	2.82663306
56	DNA demethylation (GO:0080111)	2.81475785
57	attachment of spindle microtubules to kinetochore (GO:0008608)	2.80798166
58	reflex (GO:0060004)	2.80275841
59	interferon-gamma production (GO:0032609)	2.79600805
60	platelet dense granule organization (GO:0060155)	2.79375136
61	preassembly of GPI anchor in ER membrane (GO:0016254)	2.79205218
62	ketone body metabolic process (GO:1902224)	2.77555423
63	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.77254768
64	L-fucose catabolic process (GO:0042355)	2.75517771
65	fucose catabolic process (GO:0019317)	2.75517771
66	L-fucose metabolic process (GO:0042354)	2.75517771
67	protein K63-linked deubiquitination (GO:0070536)	2.73840727
68	somatic diversification of immune receptors via germline recombination within a single locus (GO:000	2.73215053
69	somatic cell DNA recombination (GO:0016444)	2.73215053
70	keratinocyte development (GO:0003334)	2.70451990
71	regulation of mesoderm development (GO:2000380)	2.68998883
72	protein complex biogenesis (GO:0070271)	2.67941186
73	male meiosis (GO:0007140)	2.67015354
74	intraciliary transport (GO:0042073)	2.66372036
75	rRNA catabolic process (GO:0016075)	2.64395377
76	meiosis I (GO:0007127)	2.63466828
77	protein prenylation (GO:0018342)	2.62557280
78	prenylation (GO:0097354)	2.62557280
79	cilium morphogenesis (GO:0060271)	2.61563778
80	dopamine transport (GO:0015872)	2.60323978
81	response to pheromone (GO:0019236)	2.59824425
82	response to hydroperoxide (GO:0033194)	2.59274305
83	kinetochore organization (GO:0051383)	2.59027847
84	mitochondrial respiratory chain complex assembly (GO:0033108)	2.58854809
85	embryonic epithelial tube formation (GO:0001838)	2.57581699
86	ADP metabolic process (GO:0046031)	2.57337822
87	regulation of collateral sprouting (GO:0048670)	2.52739966
88	cysteine metabolic process (GO:0006534)	2.52323397
89	thyroid hormone metabolic process (GO:0042403)	2.51653790
90	T cell differentiation in thymus (GO:0033077)	2.51635535
91	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.49664128
92	sulfation (GO:0051923)	2.48626592
93	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.46277091
94	regulation of mitotic spindle checkpoint (GO:1903504)	2.46277091
95	indolalkylamine metabolic process (GO:0006586)	2.46093715
96	centrosome duplication (GO:0051298)	2.44592865
97	tryptophan metabolic process (GO:0006568)	2.43508450
98	response to X-ray (GO:0010165)	2.42312914
99	S-adenosylmethionine metabolic process (GO:0046500)	2.41736652
100	neuronal action potential propagation (GO:0019227)	2.41645349

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.48960924
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.29295976
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.18715800
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.81758559
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.73177525
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.72945893
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.67579807
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.66372270
9	EWS_26573619_Chip-Seq_HEK293_Human	2.50708455
10	FUS_26573619_Chip-Seq_HEK293_Human	2.42593692
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.40733534
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.37071766
13	ER_23166858_ChIP-Seq_MCF-7_Human	2.20558095
14	P300_19829295_ChIP-Seq_ESCs_Human	2.20481411
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.10792494
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.05454861
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.05345205
18	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.99309850
19	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.96909151
20	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.91261725
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.88080378
22	BCAT_22108803_ChIP-Seq_LS180_Human	1.83257287
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.74486476
24	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.72138051
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.70503275
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.68027375
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.61422937
28	STAT3_23295773_ChIP-Seq_U87_Human	1.59960665
29	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.58032464
30	AR_25329375_ChIP-Seq_VCAP_Human	1.57614856
31	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.53723385
32	SMAD4_21799915_ChIP-Seq_A2780_Human	1.53673279
33	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.53047483
34	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.51458779
35	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.50672165
36	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.49502446
37	CBP_20019798_ChIP-Seq_JUKART_Human	1.49502446
38	ELK1_19687146_ChIP-ChIP_HELA_Human	1.48638949
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.48318264
40	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.47917523
41	TCF4_23295773_ChIP-Seq_U87_Human	1.47227771
42	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.46765423
43	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.44558790
44	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.43010882
45	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.41519589
46	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.40247787
47	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.39395411
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.39184464
49	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.39025092
50	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.36721845
51	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.36635722
52	VDR_23849224_ChIP-Seq_CD4+_Human	1.36052991
53	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.35787256
54	TCF4_22108803_ChIP-Seq_LS180_Human	1.35489304
55	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.35488861
56	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.33024861
57	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.33024861
58	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.32616097
59	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.31534124
60	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.29248029
61	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.29248029
62	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.28669819
63	RUNX2_22187159_ChIP-Seq_PCA_Human	1.27402442
64	MYC_18940864_ChIP-ChIP_HL60_Human	1.27383259
65	TP53_22573176_ChIP-Seq_HFKS_Human	1.27296211
66	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.26399903
67	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.24391141
68	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.24333734
69	CDX2_22108803_ChIP-Seq_LS180_Human	1.23942183
70	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.22984509
71	NANOG_19829295_ChIP-Seq_ESCs_Human	1.22916369
72	SOX2_19829295_ChIP-Seq_ESCs_Human	1.22916369
73	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.21297851
74	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.21197187
75	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.20897397
76	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.19732389
77	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.19176714
78	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.18505189
79	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.13765721
80	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.13637480
81	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.10660872
82	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.10600749
83	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.08368584
84	P53_22387025_ChIP-Seq_ESCs_Mouse	1.07811802
85	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.07596148
86	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.07383139
87	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.05759947
88	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.05554762
89	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.04546288
90	AR_20517297_ChIP-Seq_VCAP_Human	1.03769440
91	NCOR_22424771_ChIP-Seq_293T_Human	1.02940038
92	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.02663420
93	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.01713322
94	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.00901128
95	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.00729903
96	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.00706748
97	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.00268490
98	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.99421150
99	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.99240337
100	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.98732243

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001986_abnormal_taste_sensitivity	3.22992114
2	MP0010094_abnormal_chromosome_stability	2.95305599
3	MP0008877_abnormal_DNA_methylation	2.91029931
4	MP0002876_abnormal_thyroid_physiology	2.59440543
5	MP0002102_abnormal_ear_morphology	2.57494628
6	MP0005084_abnormal_gallbladder_morpholo	2.43130303
7	MP0008058_abnormal_DNA_repair	2.37749001
8	MP0000569_abnormal_digit_pigmentation	2.15985011
9	MP0002837_dystrophic_cardiac_calcinosis	2.05959548
10	MP0001968_abnormal_touch/_nociception	2.04548336
11	MP0002736_abnormal_nociception_after	2.02579683
12	MP0006072_abnormal_retinal_apoptosis	2.00168204
13	MP0002234_abnormal_pharynx_morphology	1.98085438
14	MP0005253_abnormal_eye_physiology	1.92433618
15	MP0003252_abnormal_bile_duct	1.92111559
16	MP0003787_abnormal_imprinting	1.88584294
17	MP0003890_abnormal_embryonic-extraembry	1.88434965
18	MP0002138_abnormal_hepatobiliary_system	1.88244015
19	MP0003195_calcinosis	1.83587653
20	MP0005551_abnormal_eye_electrophysiolog	1.83351155
21	MP0003718_maternal_effect	1.82213841
22	MP0005174_abnormal_tail_pigmentation	1.77435969
23	MP0008875_abnormal_xenobiotic_pharmacok	1.76636671
24	MP0006292_abnormal_olfactory_placode	1.73751396
25	MP0002132_abnormal_respiratory_system	1.65994468
26	MP0002166_altered_tumor_susceptibility	1.65285029
27	MP0002006_tumorigenesis	1.62932212
28	MP0002095_abnormal_skin_pigmentation	1.60605266
29	MP0000427_abnormal_hair_cycle	1.58429677
30	MP0005647_abnormal_sex_gland	1.57097234
31	MP0001501_abnormal_sleep_pattern	1.56173702
32	MP0000383_abnormal_hair_follicle	1.52675784
33	MP0005645_abnormal_hypothalamus_physiol	1.50014276
34	MP0008057_abnormal_DNA_replication	1.48701845
35	MP0004133_heterotaxia	1.48505013
36	MP0002254_reproductive_system_inflammat	1.47383721
37	MP0008872_abnormal_physiological_respon	1.46907707
38	MP0000685_abnormal_immune_system	1.46548041
39	MP0003136_yellow_coat_color	1.46500724
40	MP0002928_abnormal_bile_duct	1.45583015
41	MP0004142_abnormal_muscle_tone	1.41544667
42	MP0004043_abnormal_pH_regulation	1.38768222
43	MP0001764_abnormal_homeostasis	1.27596390
44	MP0001879_abnormal_lymphatic_vessel	1.24167075
45	MP0000015_abnormal_ear_pigmentation	1.23515333
46	MP0005389_reproductive_system_phenotype	1.21352768
47	MP0001486_abnormal_startle_reflex	1.19637244
48	MP0002160_abnormal_reproductive_system	1.18024150
49	MP0009745_abnormal_behavioral_response	1.17728553
50	MP0008789_abnormal_olfactory_epithelium	1.15967511
51	MP0005671_abnormal_response_to	1.15777157
52	MP0001529_abnormal_vocalization	1.15416179
53	MP0002938_white_spotting	1.14999076
54	MP0004215_abnormal_myocardial_fiber	1.14894719
55	MP0002163_abnormal_gland_morphology	1.13775221
56	MP0005410_abnormal_fertilization	1.13042108
57	MP0003646_muscle_fatigue	1.12942856
58	MP0000372_irregular_coat_pigmentation	1.12008887
59	MP0000371_diluted_coat_color	1.10022281
60	MP0005075_abnormal_melanosome_morpholog	1.08223679
61	MP0005646_abnormal_pituitary_gland	1.05613161
62	MP0003880_abnormal_central_pattern	0.98001618
63	MP0001919_abnormal_reproductive_system	0.96027932
64	MP0002210_abnormal_sex_determination	0.94851537
65	MP0005499_abnormal_olfactory_system	0.92903901
66	MP0005394_taste/olfaction_phenotype	0.92903901
67	MP0002693_abnormal_pancreas_physiology	0.91565932
68	MP0000470_abnormal_stomach_morphology	0.91413698
69	MP0000653_abnormal_sex_gland	0.90627955
70	MP0003943_abnormal_hepatobiliary_system	0.90087519
71	MP0009785_altered_susceptibility_to	0.88050529
72	MP0005379_endocrine/exocrine_gland_phen	0.86461532
73	MP0010678_abnormal_skin_adnexa	0.85048934
74	MP0002075_abnormal_coat/hair_pigmentati	0.84091795
75	MP0001929_abnormal_gametogenesis	0.83895114
76	MP0001145_abnormal_male_reproductive	0.83413188
77	MP0003186_abnormal_redox_activity	0.83253100
78	MP0004134_abnormal_chest_morphology	0.82959982
79	MP0006276_abnormal_autonomic_nervous	0.82483826
80	MP0004147_increased_porphyrin_level	0.81256923
81	MP0003121_genomic_imprinting	0.80725254
82	MP0003698_abnormal_male_reproductive	0.79813190
83	MP0002272_abnormal_nervous_system	0.79328113
84	MP0005391_vision/eye_phenotype	0.78170664
85	MP0003011_delayed_dark_adaptation	0.78151562
86	MP0002638_abnormal_pupillary_reflex	0.77682452
87	MP0000631_abnormal_neuroendocrine_gland	0.77591052
88	MP0005387_immune_system_phenotype	0.76860267
89	MP0001790_abnormal_immune_system	0.76860267
90	MP0005395_other_phenotype	0.76020391
91	MP0004924_abnormal_behavior	0.75516806
92	MP0005386_behavior/neurological_phenoty	0.75516806
93	MP0000647_abnormal_sebaceous_gland	0.74093948
94	MP0009046_muscle_twitch	0.72736013
95	MP0005195_abnormal_posterior_eye	0.71582013
96	MP0005167_abnormal_blood-brain_barrier	0.71439058
97	MP0003137_abnormal_impulse_conducting	0.70232677
98	MP0001119_abnormal_female_reproductive	0.69780196
99	MP0006036_abnormal_mitochondrial_physio	0.69528431
100	MP0001944_abnormal_pancreas_morphology	0.69403724

Predicted human phenotypes

Rank	Gene Set	Z-score
1	B lymphocytopenia (HP:0010976)	5.61118150
2	Severe combined immunodeficiency (HP:0004430)	5.56103568
3	Thyroiditis (HP:0100646)	5.39719380
4	Abnormality of B cell number (HP:0010975)	5.25395181
5	Hypoproteinemia (HP:0003075)	4.56057717
6	Combined immunodeficiency (HP:0005387)	4.55644990
7	Panhypogammaglobulinemia (HP:0003139)	4.21670529
8	Hyperventilation (HP:0002883)	4.17054673
9	Hypoplasia of the thymus (HP:0000778)	4.11158050
10	Stomach cancer (HP:0012126)	3.03144226
11	Pancreatic cysts (HP:0001737)	3.01465159
12	Abnormality of midbrain morphology (HP:0002418)	2.99941034
13	Molar tooth sign on MRI (HP:0002419)	2.99941034
14	Intestinal atresia (HP:0011100)	2.95904331
15	Erythroderma (HP:0001019)	2.94796553
16	Gaze-evoked nystagmus (HP:0000640)	2.89949796
17	T lymphocytopenia (HP:0005403)	2.79906942
18	Eosinophilia (HP:0001880)	2.70697646
19	Absent speech (HP:0001344)	2.67898349
20	Prostate neoplasm (HP:0100787)	2.65303810
21	Chronic hepatic failure (HP:0100626)	2.64175164
22	Atonic seizures (HP:0010819)	2.59052675
23	Genetic anticipation (HP:0003743)	2.57365617
24	Type II lissencephaly (HP:0007260)	2.57036786
25	Abnormality of eosinophils (HP:0001879)	2.55459216
26	Progressive cerebellar ataxia (HP:0002073)	2.55182907
27	Severe visual impairment (HP:0001141)	2.50659201
28	Oligodactyly (hands) (HP:0001180)	2.50387809
29	Abnormality of T cell number (HP:0011839)	2.49894770
30	Pendular nystagmus (HP:0012043)	2.43347903
31	Absence seizures (HP:0002121)	2.36897103
32	Congenital stationary night blindness (HP:0007642)	2.34894824
33	Congenital sensorineural hearing impairment (HP:0008527)	2.33277978
34	Nephronophthisis (HP:0000090)	2.33030110
35	IgG deficiency (HP:0004315)	2.29634504
36	Pancreatic fibrosis (HP:0100732)	2.28500598
37	True hermaphroditism (HP:0010459)	2.27313234
38	Progressive inability to walk (HP:0002505)	2.22991923
39	Widely spaced teeth (HP:0000687)	2.22785200
40	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.14001173
41	Abnormality of the renal medulla (HP:0100957)	2.12879979
42	Abnormality of macular pigmentation (HP:0008002)	2.12541277
43	Dialeptic seizures (HP:0011146)	2.10247650
44	Hepatocellular necrosis (HP:0001404)	2.08514484
45	Abnormal drinking behavior (HP:0030082)	2.08333614
46	Polydipsia (HP:0001959)	2.08333614
47	Hypothermia (HP:0002045)	2.03559084
48	Hypomagnesemia (HP:0002917)	2.02225135
49	Colon cancer (HP:0003003)	2.01271643
50	Chronic diarrhea (HP:0002028)	1.97951010
51	Cupped ear (HP:0000378)	1.95847869
52	Granulocytopenia (HP:0001913)	1.94489780
53	Abnormality of the renal cortex (HP:0011035)	1.94063343
54	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.93707223
55	Tubulointerstitial nephritis (HP:0001970)	1.92873370
56	Inability to walk (HP:0002540)	1.92805827
57	Attenuation of retinal blood vessels (HP:0007843)	1.91317543
58	Cerebellar dysplasia (HP:0007033)	1.90412703
59	Abnormality of the labia minora (HP:0012880)	1.88497025
60	Alveolar cell carcinoma (HP:0006519)	1.87793133
61	Abnormality of chromosome stability (HP:0003220)	1.87417968
62	Neoplasm of the tracheobronchial system (HP:0100552)	1.86454440
63	Protruding tongue (HP:0010808)	1.86079662
64	Febrile seizures (HP:0002373)	1.84494863
65	Chronic sinusitis (HP:0011109)	1.83545147
66	Clubbing of toes (HP:0100760)	1.82809575
67	Retinal dysplasia (HP:0007973)	1.81079529
68	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.78293602
69	Esophageal atresia (HP:0002032)	1.78213870
70	Abnormality of the pons (HP:0007361)	1.77747819
71	Abnormal rod and cone electroretinograms (HP:0008323)	1.77462728
72	Hepatic necrosis (HP:0002605)	1.76741509
73	Breast carcinoma (HP:0003002)	1.76603573
74	Hypoplasia of the uterus (HP:0000013)	1.75787273
75	Hypoplasia of the pons (HP:0012110)	1.75526667
76	Anencephaly (HP:0002323)	1.73870813
77	Cystic liver disease (HP:0006706)	1.73686821
78	Double outlet right ventricle (HP:0001719)	1.73145768
79	Congenital malformation of the right heart (HP:0011723)	1.73145768
80	Aqueductal stenosis (HP:0002410)	1.73010072
81	Pigmentary retinal degeneration (HP:0001146)	1.71389809
82	Disproportionate short-trunk short stature (HP:0003521)	1.69960022
83	Bifid tongue (HP:0010297)	1.69794576
84	Abnormality of DNA repair (HP:0003254)	1.67830980
85	Aplasia/hypoplasia of the uterus (HP:0008684)	1.67641769
86	Gastrointestinal atresia (HP:0002589)	1.67398573
87	Abnormality of the prostate (HP:0008775)	1.66121459
88	Lissencephaly (HP:0001339)	1.65539607
89	Abnormality of T cells (HP:0002843)	1.65446862
90	Increased CSF lactate (HP:0002490)	1.64857661
91	Hypochromic microcytic anemia (HP:0004840)	1.64651713
92	Oculomotor apraxia (HP:0000657)	1.64274251
93	Aplasia/Hypoplasia of the thymus (HP:0010515)	1.64147333
94	Barrel-shaped chest (HP:0001552)	1.63530894
95	Mitochondrial inheritance (HP:0001427)	1.63446459
96	Abnormality of the ileum (HP:0001549)	1.62656430
97	Tetany (HP:0001281)	1.62502942
98	Abolished electroretinogram (ERG) (HP:0000550)	1.62116554
99	Meckel diverticulum (HP:0002245)	1.61506982
100	Tachypnea (HP:0002789)	1.61470663

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.63995759
2	WNK3	3.03336073
3	BMPR1B	3.01349313
4	TXK	2.47836832
5	CASK	2.45327272
6	EIF2AK3	2.32030600
7	PINK1	2.30644546
8	NUAK1	2.30463857
9	ACVR1B	2.29831657
10	OXSR1	2.21822798
11	GRK1	2.21192683
12	MAP4K2	1.99653857
13	TAF1	1.96732713
14	ADRBK2	1.93475768
15	MKNK2	1.84031967
16	MST4	1.78891534
17	ZAK	1.71898274
18	MAPK13	1.69019194
19	PRKD3	1.67389417
20	BRD4	1.60967528
21	VRK2	1.58085608
22	CDK19	1.57244194
23	MAP3K4	1.56794047
24	PNCK	1.51792964
25	TAOK3	1.50647801
26	MAP3K14	1.48845975
27	TRIM28	1.46398384
28	AKT3	1.23968629
29	PDK2	1.22140619
30	MKNK1	1.15607016
31	STK38L	1.13278265
32	STK39	1.01763996
33	PLK3	1.01112364
34	MAP3K7	0.95105096
35	STK16	0.94099358
36	TLK1	0.93908998
37	ERBB3	0.91305767
38	VRK1	0.91054857
39	FGFR2	0.90596483
40	DYRK2	0.89163350
41	PLK2	0.85701398
42	TGFBR1	0.85105960
43	ERBB4	0.84826163
44	TNIK	0.84809354
45	BRSK2	0.83658327
46	TIE1	0.80818111
47	EIF2AK2	0.77143147
48	MAP2K7	0.77101073
49	INSRR	0.76422073
50	YES1	0.76243595
51	BUB1	0.75718760
52	NLK	0.74993750
53	NEK1	0.73708507
54	PAK3	0.73023189
55	WNK4	0.72429126
56	TNK2	0.69689836
57	EIF2AK1	0.67955087
58	PLK4	0.66081769
59	MAPKAPK5	0.65283099
60	CSNK1G1	0.64679381
61	IKBKB	0.63564469
62	PRKCE	0.63451400
63	STK3	0.60937325
64	MARK3	0.59195690
65	PLK1	0.58413883
66	IKBKE	0.57650511
67	FLT3	0.57020561
68	IRAK1	0.54604444
69	TEC	0.52867395
70	TRPM7	0.52574792
71	TSSK6	0.52003087
72	MET	0.51629376
73	CSNK1G2	0.49661045
74	MAP3K6	0.49086843
75	PBK	0.48639324
76	PRKCQ	0.47889206
77	WEE1	0.47874496
78	MAP2K4	0.45859277
79	NME1	0.45547321
80	CLK1	0.42606201
81	ADRBK1	0.41701659
82	CDK3	0.41392990
83	PIK3CG	0.41326507
84	DYRK1A	0.41229453
85	CHUK	0.41087040
86	ABL1	0.41008221
87	STK11	0.37713751
88	MAP2K6	0.37066908
89	TGFBR2	0.36941383
90	CHEK2	0.36630685
91	NEK6	0.36606067
92	CSNK1A1L	0.36023242
93	CSF1R	0.35757902
94	ATM	0.35098457
95	MAP2K2	0.35015399
96	ERBB2	0.34871761
97	PKN1	0.34201661
98	PRKAA2	0.33922891
99	ATR	0.32178339
100	PRKG1	0.31712255

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Non-homologous end-joining_Homo sapiens_hsa03450	4.72823393
2	Homologous recombination_Homo sapiens_hsa03440	3.20540111
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.76318195
4	Fanconi anemia pathway_Homo sapiens_hsa03460	2.52743372
5	Propanoate metabolism_Homo sapiens_hsa00640	2.49551106
6	Butanoate metabolism_Homo sapiens_hsa00650	2.48237779
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.46778975
8	Phototransduction_Homo sapiens_hsa04744	2.44511229
9	Caffeine metabolism_Homo sapiens_hsa00232	2.27366308
10	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.19772827
11	Basal transcription factors_Homo sapiens_hsa03022	2.19305182
12	RNA polymerase_Homo sapiens_hsa03020	2.15869781
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.11645227
14	Primary immunodeficiency_Homo sapiens_hsa05340	2.08468709
15	Protein export_Homo sapiens_hsa03060	2.03089782
16	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.86948672
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.85607507
18	Selenocompound metabolism_Homo sapiens_hsa00450	1.82741050
19	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.79082124
20	Proteasome_Homo sapiens_hsa03050	1.78251890
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.60828922
22	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.60566717
23	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.55600349
24	RNA degradation_Homo sapiens_hsa03018	1.43500869
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.40917763
26	Ether lipid metabolism_Homo sapiens_hsa00565	1.39009406
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.36908268
28	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.34906748
29	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.28388594
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.23910955
31	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.22966710
32	Nicotine addiction_Homo sapiens_hsa05033	1.18023702
33	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.16933976
34	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.13161745
35	Salivary secretion_Homo sapiens_hsa04970	1.08377568
36	Oxidative phosphorylation_Homo sapiens_hsa00190	1.04218926
37	Mismatch repair_Homo sapiens_hsa03430	1.02341143
38	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.01753320
39	Taste transduction_Homo sapiens_hsa04742	1.00350619
40	Purine metabolism_Homo sapiens_hsa00230	1.00110327
41	Peroxisome_Homo sapiens_hsa04146	0.99083588
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.99064226
43	Nucleotide excision repair_Homo sapiens_hsa03420	0.97320635
44	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.95981960
45	Tryptophan metabolism_Homo sapiens_hsa00380	0.89822894
46	Olfactory transduction_Homo sapiens_hsa04740	0.89477544
47	Collecting duct acid secretion_Homo sapiens_hsa04966	0.88868958
48	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.88361207
49	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.86691945
50	One carbon pool by folate_Homo sapiens_hsa00670	0.83848602
51	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.82314403
52	RNA transport_Homo sapiens_hsa03013	0.81833452
53	Retinol metabolism_Homo sapiens_hsa00830	0.80853833
54	p53 signaling pathway_Homo sapiens_hsa04115	0.78898148
55	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.78107002
56	Regulation of autophagy_Homo sapiens_hsa04140	0.73591916
57	Parkinsons disease_Homo sapiens_hsa05012	0.70905767
58	Legionellosis_Homo sapiens_hsa05134	0.67597239
59	Sulfur metabolism_Homo sapiens_hsa00920	0.67216595
60	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.66594636
61	Asthma_Homo sapiens_hsa05310	0.65775528
62	beta-Alanine metabolism_Homo sapiens_hsa00410	0.63713082
63	Glycerolipid metabolism_Homo sapiens_hsa00561	0.63471930
64	Type I diabetes mellitus_Homo sapiens_hsa04940	0.61640751
65	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.59787957
66	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.59016047
67	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.58757641
68	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.57056072
69	Serotonergic synapse_Homo sapiens_hsa04726	0.53808535
70	Huntingtons disease_Homo sapiens_hsa05016	0.52892057
71	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.52669263
72	Chemical carcinogenesis_Homo sapiens_hsa05204	0.49467177
73	Calcium signaling pathway_Homo sapiens_hsa04020	0.48702792
74	Metabolic pathways_Homo sapiens_hsa01100	0.48447468
75	Base excision repair_Homo sapiens_hsa03410	0.47577070
76	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.45787869
77	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.45086373
78	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.44563166
79	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.44434923
80	Pyrimidine metabolism_Homo sapiens_hsa00240	0.43359159
81	Insulin secretion_Homo sapiens_hsa04911	0.42138293
82	ABC transporters_Homo sapiens_hsa02010	0.41986250
83	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.40014881
84	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.39908970
85	Mineral absorption_Homo sapiens_hsa04978	0.39646385
86	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.38982390
87	Morphine addiction_Homo sapiens_hsa05032	0.38795962
88	Glutathione metabolism_Homo sapiens_hsa00480	0.37561930
89	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.36122422
90	Fatty acid metabolism_Homo sapiens_hsa01212	0.34497914
91	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.32514854
92	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.32069524
93	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.31314918
94	Pyruvate metabolism_Homo sapiens_hsa00620	0.30887217
95	Fatty acid degradation_Homo sapiens_hsa00071	0.29248007
96	Allograft rejection_Homo sapiens_hsa05330	0.27708583
97	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.26955834
98	FoxO signaling pathway_Homo sapiens_hsa04068	0.26165641
99	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.25781757
100	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.25001187

BRI3BPP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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