BRI3P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.58690707
2pyrimidine deoxyribonucleotide catabolic process (GO:0009223)6.80953252
3base-excision repair, AP site formation (GO:0006285)6.42329692
4sequestering of actin monomers (GO:0042989)6.31754368
5pyrimidine nucleobase catabolic process (GO:0006208)6.14972089
6DNA integration (GO:0015074)6.06699249
7pyrimidine nucleotide catabolic process (GO:0006244)5.72061028
8epithelial cilium movement (GO:0003351)4.85590934
9nucleobase catabolic process (GO:0046113)4.82211654
10platelet dense granule organization (GO:0060155)4.77346984
11protein neddylation (GO:0045116)4.68406670
12protein polyglutamylation (GO:0018095)4.54574299
13regulation of development, heterochronic (GO:0040034)4.49903474
14pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.48498077
15protein targeting to peroxisome (GO:0006625)4.39096467
16establishment of protein localization to peroxisome (GO:0072663)4.39096467
17protein localization to peroxisome (GO:0072662)4.39096467
18G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.29827396
19monoubiquitinated protein deubiquitination (GO:0035520)4.26505108
20water-soluble vitamin biosynthetic process (GO:0042364)4.24461442
21regulation of timing of cell differentiation (GO:0048505)4.18003049
22peroxisomal transport (GO:0043574)4.08432508
23deoxyribonucleotide catabolic process (GO:0009264)4.07747448
24postsynaptic membrane organization (GO:0001941)3.98137702
25positive regulation of male gonad development (GO:2000020)3.96053524
26cilium movement (GO:0003341)3.94943783
27auditory behavior (GO:0031223)3.86336468
28aggressive behavior (GO:0002118)3.85551608
29axonemal dynein complex assembly (GO:0070286)3.85483529
30substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.81998787
31substrate-independent telencephalic tangential migration (GO:0021826)3.81998787
32forebrain neuron differentiation (GO:0021879)3.81623493
33establishment of tissue polarity (GO:0007164)3.74171545
34establishment of planar polarity (GO:0001736)3.74171545
35deoxyribose phosphate catabolic process (GO:0046386)3.71381321
36spliceosomal complex assembly (GO:0000245)3.70100793
37presynaptic membrane assembly (GO:0097105)3.68061140
38cilium or flagellum-dependent cell motility (GO:0001539)3.60139711
39peroxisome organization (GO:0007031)3.60086193
40regulation of cilium movement (GO:0003352)3.59123611
41cerebral cortex neuron differentiation (GO:0021895)3.55612207
42negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.53721665
43pyrimidine dimer repair (GO:0006290)3.45690732
44negative regulation of oligodendrocyte differentiation (GO:0048715)3.45582458
45negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.41238484
46olfactory bulb development (GO:0021772)3.39283136
47intraciliary transport (GO:0042073)3.33210433
48behavioral response to nicotine (GO:0035095)3.31053829
49calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.26857177
50ubiquinone metabolic process (GO:0006743)3.24324292
51anterograde synaptic vesicle transport (GO:0048490)3.22152713
52protein import into peroxisome matrix (GO:0016558)3.21276369
53synapse assembly (GO:0007416)3.18595798
54chaperone-mediated protein transport (GO:0072321)3.16071727
55ubiquinone biosynthetic process (GO:0006744)3.13910383
56axoneme assembly (GO:0035082)3.13383576
57glial cell proliferation (GO:0014009)3.12027009
58tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.11433072
59RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.11433072
60mitochondrial calcium ion transport (GO:0006851)3.11380290
61cholesterol biosynthetic process (GO:0006695)3.11104644
62dentate gyrus development (GO:0021542)3.10131376
63regulation of microtubule-based movement (GO:0060632)3.08617060
64melanosome transport (GO:0032402)3.07929404
65regulation of male gonad development (GO:2000018)3.04902154
66regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.04255890
67retinal rod cell development (GO:0046548)3.04080285
68negative regulation of astrocyte differentiation (GO:0048712)3.02666231
69neuron cell-cell adhesion (GO:0007158)3.02613833
70neuron fate determination (GO:0048664)3.02109021
71establishment of melanosome localization (GO:0032401)3.00318533
72synaptic vesicle exocytosis (GO:0016079)2.99994953
73pigment granule transport (GO:0051904)2.96115160
74mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.95817828
75positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.95817828
76response to auditory stimulus (GO:0010996)2.95259755
77pyrimidine-containing compound catabolic process (GO:0072529)2.93453008
78neural tube formation (GO:0001841)2.90379555
79establishment of pigment granule localization (GO:0051905)2.89348859
80iron-sulfur cluster assembly (GO:0016226)2.89140862
81metallo-sulfur cluster assembly (GO:0031163)2.89140862
82regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.89024219
83secretory granule organization (GO:0033363)2.88805406
84cilium morphogenesis (GO:0060271)2.88263949
85layer formation in cerebral cortex (GO:0021819)2.85352679
86presynaptic membrane organization (GO:0097090)2.83787841
87regulation of mitochondrial translation (GO:0070129)2.83200477
88isoprenoid biosynthetic process (GO:0008299)2.83075269
89sterol biosynthetic process (GO:0016126)2.82943848
90cell proliferation in forebrain (GO:0021846)2.82739396
91melanosome localization (GO:0032400)2.81375605
92spinal cord association neuron differentiation (GO:0021527)2.78606454
93prostate gland growth (GO:0060736)2.74012614
94pigment granule localization (GO:0051875)2.72041222
95male sex determination (GO:0030238)2.67140772
96positive regulation of mitochondrial fission (GO:0090141)2.66718311
97negative regulation of DNA-templated transcription, elongation (GO:0032785)2.65116429
98regulation of respiratory system process (GO:0044065)2.64579709
99peptidyl-arginine N-methylation (GO:0035246)2.64106264
100peptidyl-arginine methylation (GO:0018216)2.64106264

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human4.94406141
2ZNF274_21170338_ChIP-Seq_K562_Hela3.91926991
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.34227985
4IRF1_19129219_ChIP-ChIP_H3396_Human3.22596998
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.75604379
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.69891590
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.44789952
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.41495011
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.32175115
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.27572699
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23958675
12TAF15_26573619_Chip-Seq_HEK293_Human2.17720341
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14870941
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.12545446
15VDR_23849224_ChIP-Seq_CD4+_Human2.09757552
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.06343306
17SOX2_18555785_ChIP-Seq_MESCs_Mouse1.96900145
18SOX2_16153702_ChIP-ChIP_HESCs_Human1.93549405
19CIITA_25753668_ChIP-Seq_RAJI_Human1.91764016
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86618357
21GATA1_26923725_Chip-Seq_HPCs_Mouse1.77760734
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77729224
23VDR_22108803_ChIP-Seq_LS180_Human1.77174897
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.76673288
25EWS_26573619_Chip-Seq_HEK293_Human1.76404088
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.76320221
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.74728376
28MYC_18940864_ChIP-ChIP_HL60_Human1.72464985
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70951756
30POU5F1_16153702_ChIP-ChIP_HESCs_Human1.70357934
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.68747658
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.66094800
33EZH2_22144423_ChIP-Seq_EOC_Human1.60751895
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.60003511
35GABP_19822575_ChIP-Seq_HepG2_Human1.55258614
36ELK1_19687146_ChIP-ChIP_HELA_Human1.53296066
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.53020828
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52755502
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49254385
40RNF2_27304074_Chip-Seq_NSC_Mouse1.46958298
41POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.46605041
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45834300
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44715762
44DCP1A_22483619_ChIP-Seq_HELA_Human1.37255590
45PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.35672252
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33653939
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.33262264
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.32557160
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27175590
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26478907
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25924330
52FOXP3_21729870_ChIP-Seq_TREG_Human1.25270243
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21892052
54P300_19829295_ChIP-Seq_ESCs_Human1.18156776
55TP53_22573176_ChIP-Seq_HFKS_Human1.17714414
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17637217
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16564456
58CBP_20019798_ChIP-Seq_JUKART_Human1.16564456
59GBX2_23144817_ChIP-Seq_PC3_Human1.15561208
60DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15050623
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14707495
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14147854
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13903190
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13207524
65ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13062557
66XRN2_22483619_ChIP-Seq_HELA_Human1.08400328
67REST_18959480_ChIP-ChIP_MESCs_Mouse1.08054974
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07922943
69SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07400631
70AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06362606
71AR_20517297_ChIP-Seq_VCAP_Human1.06247742
72CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05754942
73SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05517063
74TAL1_26923725_Chip-Seq_HPCs_Mouse1.05042204
75KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04635772
76SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.04590637
77CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.04232815
78CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02408492
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.02036410
80CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01414524
81REST_21632747_ChIP-Seq_MESCs_Mouse1.00467746
82EED_16625203_ChIP-ChIP_MESCs_Mouse1.00164335
83SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98648595
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97111243
85FUS_26573619_Chip-Seq_HEK293_Human0.96595736
86WDR5_24793694_ChIP-Seq_LNCAP_Human0.96091336
87ELF1_20517297_ChIP-Seq_JURKAT_Human0.95990933
88JARID2_20064375_ChIP-Seq_MESCs_Mouse0.95808128
89TAF2_19829295_ChIP-Seq_ESCs_Human0.95234162
90NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93669314
91ELK4_26923725_Chip-Seq_MESODERM_Mouse0.92871827
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91410826
93ERA_21632823_ChIP-Seq_H3396_Human0.90144857
94KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88676666
95SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88575007
96TTF2_22483619_ChIP-Seq_HELA_Human0.88556511
97P53_21459846_ChIP-Seq_SAOS-2_Human0.87360190
98EZH2_27304074_Chip-Seq_ESCs_Mouse0.87155918
99ETV2_25802403_ChIP-Seq_MESCs_Mouse0.87151439
100RBPJ_22232070_ChIP-Seq_NCS_Mouse0.86153212

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization5.23083579
2MP0008789_abnormal_olfactory_epithelium3.77528917
3MP0003122_maternal_imprinting3.35703538
4MP0005645_abnormal_hypothalamus_physiol3.12251790
5MP0005394_taste/olfaction_phenotype2.97733086
6MP0005499_abnormal_olfactory_system2.97733086
7MP0002653_abnormal_ependyma_morphology2.92738589
8MP0006072_abnormal_retinal_apoptosis2.72237440
9MP0006292_abnormal_olfactory_placode2.71247487
10MP0000778_abnormal_nervous_system2.62472005
11MP0001502_abnormal_circadian_rhythm2.61261804
12MP0002009_preneoplasia2.39727391
13MP0000049_abnormal_middle_ear2.32047995
14MP0001984_abnormal_olfaction2.22375044
15MP0000569_abnormal_digit_pigmentation2.20451529
16MP0005253_abnormal_eye_physiology1.98576802
17MP0000566_synostosis1.89437063
18MP0000026_abnormal_inner_ear1.86307264
19MP0003121_genomic_imprinting1.78284517
20MP0000631_abnormal_neuroendocrine_gland1.76746988
21MP0004742_abnormal_vestibular_system1.64090939
22MP0000015_abnormal_ear_pigmentation1.64023882
23MP0003221_abnormal_cardiomyocyte_apopto1.63277751
24MP0004142_abnormal_muscle_tone1.61167507
25MP0001324_abnormal_eye_pigmentation1.61078837
26MP0004133_heterotaxia1.59969341
27MP0001905_abnormal_dopamine_level1.56938887
28MP0003646_muscle_fatigue1.53081235
29MP0005551_abnormal_eye_electrophysiolog1.49929246
30MP0000343_altered_response_to1.48891602
31MP0001299_abnormal_eye_distance/1.47027745
32MP0010234_abnormal_vibrissa_follicle1.45423006
33MP0001485_abnormal_pinna_reflex1.45100437
34MP0003787_abnormal_imprinting1.39463628
35MP0008995_early_reproductive_senescence1.39347440
36MP0002572_abnormal_emotion/affect_behav1.35331283
37MP0004924_abnormal_behavior1.33800904
38MP0005386_behavior/neurological_phenoty1.33800904
39MP0006276_abnormal_autonomic_nervous1.33459086
40MP0002638_abnormal_pupillary_reflex1.33318582
41MP0001270_distended_abdomen1.30670182
42MP0005423_abnormal_somatic_nervous1.29259555
43MP0002234_abnormal_pharynx_morphology1.27813995
44MP0003567_abnormal_fetal_cardiomyocyte1.26042659
45MP0001727_abnormal_embryo_implantation1.23617724
46MP0001486_abnormal_startle_reflex1.22816478
47MP0009046_muscle_twitch1.21872210
48MP0010030_abnormal_orbit_morphology1.21329583
49MP0001963_abnormal_hearing_physiology1.21249618
50MP0005195_abnormal_posterior_eye1.21138269
51MP0002102_abnormal_ear_morphology1.20268188
52MP0004270_analgesia1.19581952
53MP0002557_abnormal_social/conspecific_i1.19059467
54MP0002752_abnormal_somatic_nervous1.17050773
55MP0005248_abnormal_Harderian_gland1.14708071
56MP0002733_abnormal_thermal_nociception1.14166341
57MP0003938_abnormal_ear_development1.13905756
58MP0002090_abnormal_vision1.13852151
59MP0008058_abnormal_DNA_repair1.12503137
60MP0003137_abnormal_impulse_conducting1.11600307
61MP0002909_abnormal_adrenal_gland1.10929189
62MP0002177_abnormal_outer_ear1.09182923
63MP0001293_anophthalmia1.08338486
64MP0002882_abnormal_neuron_morphology1.07379900
65MP0005623_abnormal_meninges_morphology1.04563508
66MP0005646_abnormal_pituitary_gland1.04297722
67MP0002095_abnormal_skin_pigmentation1.02896806
68MP0002166_altered_tumor_susceptibility1.00562594
69MP0004043_abnormal_pH_regulation0.99930721
70MP0003635_abnormal_synaptic_transmissio0.98031575
71MP0002928_abnormal_bile_duct0.97877183
72MP0003755_abnormal_palate_morphology0.96882889
73MP0002152_abnormal_brain_morphology0.96533846
74MP0005391_vision/eye_phenotype0.95585065
75MP0002063_abnormal_learning/memory/cond0.94453869
76MP0009384_cardiac_valve_regurgitation0.93531655
77MP0000537_abnormal_urethra_morphology0.92992050
78MP0001340_abnormal_eyelid_morphology0.92888791
79MP0001968_abnormal_touch/_nociception0.92399711
80MP0005647_abnormal_sex_gland0.92234572
81MP0002184_abnormal_innervation0.92190962
82MP0001970_abnormal_pain_threshold0.89450014
83MP0002006_tumorigenesis0.88266020
84MP0003937_abnormal_limbs/digits/tail_de0.86771957
85MP0002233_abnormal_nose_morphology0.86475605
86MP0002064_seizures0.86462366
87MP0001835_abnormal_antigen_presentation0.86297950
88MP0000955_abnormal_spinal_cord0.85833702
89MP0009745_abnormal_behavioral_response0.84537491
90MP0003880_abnormal_central_pattern0.83944641
91MP0001188_hyperpigmentation0.83031257
92MP0003861_abnormal_nervous_system0.82646074
93MP0004859_abnormal_synaptic_plasticity0.82256006
94MP0002067_abnormal_sensory_capabilities0.81990858
95MP0009764_decreased_sensitivity_to0.78939134
96MP0002751_abnormal_autonomic_nervous0.78555116
97MP0002272_abnormal_nervous_system0.78281117
98MP0005671_abnormal_response_to0.74414360
99MP0000647_abnormal_sebaceous_gland0.73333644
100MP0000427_abnormal_hair_cycle0.73023504

Predicted human phenotypes

RankGene SetZ-score
1Nuclear cataract (HP:0100018)7.73318267
2True hermaphroditism (HP:0010459)4.20563069
3Abnormal respiratory motile cilium morphology (HP:0005938)3.66865278
4Abnormal respiratory epithelium morphology (HP:0012253)3.66865278
5Molar tooth sign on MRI (HP:0002419)3.45105696
6Abnormality of midbrain morphology (HP:0002418)3.45105696
7Broad alveolar ridges (HP:0000187)3.40587170
8Pancreatic fibrosis (HP:0100732)3.38981700
9Chronic bronchitis (HP:0004469)3.31579092
10Degeneration of the lateral corticospinal tracts (HP:0002314)3.31254567
11Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.31254567
12Colon cancer (HP:0003003)3.15263332
13Hyperglycinemia (HP:0002154)3.13200983
14Degeneration of anterior horn cells (HP:0002398)3.11265422
15Abnormality of the anterior horn cell (HP:0006802)3.11265422
16Pancreatic cysts (HP:0001737)3.08547142
17Drooling (HP:0002307)3.01991475
18Zonular cataract (HP:0010920)2.95765131
19Cerebellar dysplasia (HP:0007033)2.87757613
20Excessive salivation (HP:0003781)2.85486496
21Thyroid-stimulating hormone excess (HP:0002925)2.85414824
22Back pain (HP:0003418)2.81017467
23Cortical dysplasia (HP:0002539)2.80740668
24Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.75460427
25Abnormality of the corticospinal tract (HP:0002492)2.74787548
26Cutaneous melanoma (HP:0012056)2.74218304
27Abnormal respiratory motile cilium physiology (HP:0012261)2.70981392
28Brushfield spots (HP:0001088)2.65123412
29Gait imbalance (HP:0002141)2.60833440
30Recurrent sinusitis (HP:0011108)2.60655640
31Exercise-induced muscle cramps (HP:0003710)2.58417295
32Split foot (HP:0001839)2.58347915
33Sex reversal (HP:0012245)2.58169583
34Abnormal sex determination (HP:0012244)2.58169583
35Cone-rod dystrophy (HP:0000548)2.57550521
36Posterior subcapsular cataract (HP:0007787)2.55710466
37Nephronophthisis (HP:0000090)2.54436877
38Type II lissencephaly (HP:0007260)2.52792712
39Bronchiectasis (HP:0002110)2.52588516
403-Methylglutaconic aciduria (HP:0003535)2.52281027
41Nephrogenic diabetes insipidus (HP:0009806)2.48966510
42Cystic liver disease (HP:0006706)2.48820915
43Decreased circulating renin level (HP:0003351)2.48438848
44Congenital primary aphakia (HP:0007707)2.45864835
45Supernumerary spleens (HP:0009799)2.40601925
46Facial hemangioma (HP:0000329)2.38783087
47Median cleft lip (HP:0000161)2.37253803
48Medial flaring of the eyebrow (HP:0010747)2.36219951
49Abnormality of alanine metabolism (HP:0010916)2.34372859
50Hyperalaninemia (HP:0003348)2.34372859
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.34372859
52Abnormal ciliary motility (HP:0012262)2.33099539
53Oligodactyly (HP:0012165)2.29109065
54Abnormality of the diencephalon (HP:0010662)2.22825117
55Postaxial hand polydactyly (HP:0001162)2.20491951
56Postaxial foot polydactyly (HP:0001830)2.19491806
57Oligodactyly (hands) (HP:0001180)2.15228690
58Myoglobinuria (HP:0002913)2.14852672
59Atrophy/Degeneration involving motor neurons (HP:0007373)2.13049871
60Lissencephaly (HP:0001339)2.12669062
61Abnormality of serine family amino acid metabolism (HP:0010894)2.10598193
62Abnormality of glycine metabolism (HP:0010895)2.10598193
63Bronchitis (HP:0012387)2.09148894
64Chronic sinusitis (HP:0011109)2.08977564
65Failure to thrive in infancy (HP:0001531)2.07511660
66Neonatal respiratory distress (HP:0002643)2.05868322
67Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.03380280
68Decreased activity of mitochondrial respiratory chain (HP:0008972)2.03380280
69Abnormality of the metopic suture (HP:0005556)2.01011925
70Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.99704175
71Lipid accumulation in hepatocytes (HP:0006561)1.99193735
72Abnormal biliary tract physiology (HP:0012439)1.97575149
73Bile duct proliferation (HP:0001408)1.97575149
74Rhinitis (HP:0012384)1.95701678
75Abnormality of the alveolar ridges (HP:0006477)1.95670145
76Specific learning disability (HP:0001328)1.94961432
77Thickened nuchal skin fold (HP:0000474)1.94432806
78Acute necrotizing encephalopathy (HP:0006965)1.94067188
79Hyperactive renin-angiotensin system (HP:0000841)1.90814389
80Microretrognathia (HP:0000308)1.90102841
81Progressive microcephaly (HP:0000253)1.89594778
82Preaxial hand polydactyly (HP:0001177)1.85443229
83Retinal dysplasia (HP:0007973)1.85364897
84Hypoplasia of the brainstem (HP:0002365)1.84821863
85Aplasia/Hypoplasia of the brainstem (HP:0007362)1.84821863
86Broad palm (HP:0001169)1.84516958
87Meningocele (HP:0002435)1.83652469
88Hemiparesis (HP:0001269)1.83369803
89Increased hepatocellular lipid droplets (HP:0006565)1.83182264
90Deep palmar crease (HP:0006191)1.82191787
91Chronic hepatic failure (HP:0100626)1.79597779
92Abnormality of the renal medulla (HP:0100957)1.78429212
93Abnormality of serum amino acid levels (HP:0003112)1.78414845
94Aplasia/hypoplasia of the uterus (HP:0008684)1.78240628
95Urinary urgency (HP:0000012)1.77423046
96Abnormal mitochondria in muscle tissue (HP:0008316)1.76529425
97Methylmalonic acidemia (HP:0002912)1.75571308
98Genital tract atresia (HP:0001827)1.74468910
99Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.73566571
100Pachygyria (HP:0001302)1.73482539

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K25.83386691
2DYRK34.63937564
3WNK33.52665860
4CASK3.12994806
5BCKDK3.07319500
6MAP2K73.06375266
7MST42.48369325
8TAOK32.47983258
9TLK12.40605520
10BCR2.07612217
11MARK12.02624686
12CAMKK21.98443579
13MAP3K41.95086105
14AKT31.93190814
15ARAF1.85227245
16PIM21.75581677
17MKNK11.72922183
18CDK191.64528732
19ZAK1.62183115
20PIK3CG1.58623144
21VRK11.57020493
22BRAF1.55763806
23MAPKAPK31.48333600
24ERBB31.36757685
25MAPK131.33679890
26BRSK21.33008413
27RPS6KA41.29573600
28CSNK1G31.26672867
29CSNK1A1L1.24369509
30BRD41.23886718
31NEK91.21451063
32DYRK21.21392745
33MKNK21.14173140
34PLK41.08495650
35CSNK1G21.07585038
36PAK31.05368106
37MAP3K131.02488166
38RPS6KA50.98363866
39RAF10.96329885
40MAPK150.96112535
41MAP2K40.95969581
42DYRK1B0.86629402
43STK160.85254807
44PAK60.82520140
45DAPK30.80815682
46CSNK1G10.79699156
47ABL20.79282542
48TAOK10.79240578
49BMPR1B0.76882005
50LIMK10.73266770
51SGK2230.70837961
52SGK4940.70837961
53TRIM280.69826497
54ADRBK20.69323293
55FRK0.69285800
56KSR10.68568758
57CCNB10.62038429
58ERBB20.61400997
59ACVR1B0.60606574
60SGK20.60075114
61AURKA0.54200799
62UHMK10.53458070
63MOS0.53387522
64KSR20.52242955
65PDK20.51381542
66OXSR10.49624813
67NEK10.49207824
68DYRK1A0.48780148
69NTRK20.47119807
70BLK0.46612283
71AKT20.45307369
72EPHB20.44075251
73LMTK20.42474784
74NUAK10.41517119
75FLT30.41137491
76PKN10.40230204
77RPS6KA20.34289500
78IKBKB0.33278976
79SGK30.32309445
80EPHA40.32164473
81TESK10.31118913
82CSF1R0.30397458
83ATR0.29776722
84RPS6KA60.28881957
85MARK20.27766388
86CSNK1A10.27748742
87WNK40.27643160
88GRK10.27346950
89CAMK40.27189707
90RPS6KC10.26688397
91RPS6KL10.26688397
92ROCK20.25181209
93CAMK2B0.25069220
94SIK20.23777465
95PRKCE0.23377867
96MAPK70.23209976
97ABL10.21741514
98CAMK2A0.21343594
99CDK50.19820307
100ADRBK10.19311980

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053224.67664582
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.93826368
3Protein export_Homo sapiens_hsa030603.66380270
4Alcoholism_Homo sapiens_hsa050343.49192125
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.32072630
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.99145692
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.89092430
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.74247719
9Oxidative phosphorylation_Homo sapiens_hsa001902.55997280
10Peroxisome_Homo sapiens_hsa041462.48906657
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.00596060
12Nicotine addiction_Homo sapiens_hsa050332.00207753
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.98838736
14Asthma_Homo sapiens_hsa053101.95995991
15Steroid biosynthesis_Homo sapiens_hsa001001.90152539
16Parkinsons disease_Homo sapiens_hsa050121.87053118
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.82578684
18Proteasome_Homo sapiens_hsa030501.77829382
19Butanoate metabolism_Homo sapiens_hsa006501.60312329
20Huntingtons disease_Homo sapiens_hsa050161.56476517
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34649699
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33758707
23Spliceosome_Homo sapiens_hsa030401.29167132
24Basal cell carcinoma_Homo sapiens_hsa052171.25973575
25Nitrogen metabolism_Homo sapiens_hsa009101.16090674
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15724010
27Collecting duct acid secretion_Homo sapiens_hsa049661.13915022
28Pentose phosphate pathway_Homo sapiens_hsa000301.12495361
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11730383
30Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10037240
31Propanoate metabolism_Homo sapiens_hsa006401.09492968
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.09325401
33Biosynthesis of amino acids_Homo sapiens_hsa012301.07972407
34Regulation of autophagy_Homo sapiens_hsa041401.06517557
35Allograft rejection_Homo sapiens_hsa053301.06189929
36GABAergic synapse_Homo sapiens_hsa047271.05231553
37Alzheimers disease_Homo sapiens_hsa050101.03289173
38Carbon metabolism_Homo sapiens_hsa012000.97562409
39Autoimmune thyroid disease_Homo sapiens_hsa053200.96442432
40beta-Alanine metabolism_Homo sapiens_hsa004100.96398550
41Arginine and proline metabolism_Homo sapiens_hsa003300.94557909
42Cardiac muscle contraction_Homo sapiens_hsa042600.90301992
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86210639
44Base excision repair_Homo sapiens_hsa034100.85453675
45Axon guidance_Homo sapiens_hsa043600.79697132
46Basal transcription factors_Homo sapiens_hsa030220.79448232
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78539218
48p53 signaling pathway_Homo sapiens_hsa041150.74022014
49Graft-versus-host disease_Homo sapiens_hsa053320.73605401
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73475905
51Tryptophan metabolism_Homo sapiens_hsa003800.70856448
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67881363
53Viral myocarditis_Homo sapiens_hsa054160.66963693
54Hedgehog signaling pathway_Homo sapiens_hsa043400.66515386
55Viral carcinogenesis_Homo sapiens_hsa052030.65781319
56Pyruvate metabolism_Homo sapiens_hsa006200.64495163
57Type I diabetes mellitus_Homo sapiens_hsa049400.64377774
58Phagosome_Homo sapiens_hsa041450.64146004
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62196498
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62029677
61RNA degradation_Homo sapiens_hsa030180.62002701
62ABC transporters_Homo sapiens_hsa020100.61809477
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61213749
64Rheumatoid arthritis_Homo sapiens_hsa053230.61005885
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59981204
66Morphine addiction_Homo sapiens_hsa050320.58096282
67Antigen processing and presentation_Homo sapiens_hsa046120.55508140
68Phototransduction_Homo sapiens_hsa047440.53514673
69Epstein-Barr virus infection_Homo sapiens_hsa051690.53035473
70Primary immunodeficiency_Homo sapiens_hsa053400.52853390
71Vibrio cholerae infection_Homo sapiens_hsa051100.52617328
72Synaptic vesicle cycle_Homo sapiens_hsa047210.51717150
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49045250
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48381257
75RNA polymerase_Homo sapiens_hsa030200.48362986
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48259095
77Ether lipid metabolism_Homo sapiens_hsa005650.48082920
78Olfactory transduction_Homo sapiens_hsa047400.47934678
79Metabolic pathways_Homo sapiens_hsa011000.45600254
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44925308
81Linoleic acid metabolism_Homo sapiens_hsa005910.42926844
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42126301
83Fanconi anemia pathway_Homo sapiens_hsa034600.41741023
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.40977402
85Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40454147
86Arginine biosynthesis_Homo sapiens_hsa002200.36040353
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35043863
88Homologous recombination_Homo sapiens_hsa034400.32738730
89Fatty acid metabolism_Homo sapiens_hsa012120.32024644
90Hippo signaling pathway_Homo sapiens_hsa043900.29967734
91Arachidonic acid metabolism_Homo sapiens_hsa005900.27716249
92Fatty acid degradation_Homo sapiens_hsa000710.27648957
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26782968
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25318643
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.25240792
96Pyrimidine metabolism_Homo sapiens_hsa002400.24918843
97Sulfur relay system_Homo sapiens_hsa041220.24873290
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23743175
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23371277
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.22011477

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