BRICD5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to ATP (GO:0071318)7.59991172
2behavioral response to nicotine (GO:0035095)7.52233099
3daunorubicin metabolic process (GO:0044597)7.13722287
4polyketide metabolic process (GO:0030638)7.13722287
5doxorubicin metabolic process (GO:0044598)7.13722287
6axon ensheathment in central nervous system (GO:0032291)6.81958817
7central nervous system myelination (GO:0022010)6.81958817
8DNA strand renaturation (GO:0000733)5.82004059
9fatty acid elongation (GO:0030497)5.70663164
10regulation of synapse structural plasticity (GO:0051823)5.39948490
11presynaptic membrane assembly (GO:0097105)5.32567221
12meiotic chromosome segregation (GO:0045132)5.16070664
13adenosine receptor signaling pathway (GO:0001973)5.15383524
14negative regulation of cell aging (GO:0090344)5.02018040
15neuron cell-cell adhesion (GO:0007158)4.89086954
16negative regulation of epidermal cell differentiation (GO:0045605)4.86167720
17gonadal mesoderm development (GO:0007506)4.81759359
18purinergic nucleotide receptor signaling pathway (GO:0035590)4.79044450
19negative regulation of epidermis development (GO:0045683)4.76545471
20presynaptic membrane organization (GO:0097090)4.67766635
21regulation of nuclear cell cycle DNA replication (GO:0033262)4.66163251
22positive regulation of protein kinase C signaling (GO:0090037)4.65228916
23aminoglycoside antibiotic metabolic process (GO:0030647)4.53489545
24regulation of skeletal muscle contraction (GO:0014819)4.49125534
25response to dietary excess (GO:0002021)4.38933079
26maintenance of protein location in nucleus (GO:0051457)4.37661286
27detection of temperature stimulus (GO:0016048)4.34267338
28G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.28476041
29urinary tract smooth muscle contraction (GO:0014848)4.26071835
30cornea development in camera-type eye (GO:0061303)4.24990277
31sex determination (GO:0007530)4.19089187
32sensory perception of taste (GO:0050909)4.15914380
33regulation of response to osmotic stress (GO:0047484)4.09764485
34oligodendrocyte differentiation (GO:0048709)4.07662488
35myelination (GO:0042552)4.07022378
36axon ensheathment (GO:0008366)4.03795903
37ensheathment of neurons (GO:0007272)4.03795903
38DNA replication checkpoint (GO:0000076)3.99558551
39neuromuscular synaptic transmission (GO:0007274)3.96638385
40positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.96160481
41postsynaptic membrane organization (GO:0001941)3.84152590
42long-chain fatty acid biosynthetic process (GO:0042759)3.81633607
43regulation of pigment cell differentiation (GO:0050932)3.81240164
44iron coordination entity transport (GO:1901678)3.79343058
45melanin biosynthetic process (GO:0042438)3.75897096
46rRNA transcription (GO:0009303)3.73760299
47response to ATP (GO:0033198)3.69766133
48quinone metabolic process (GO:1901661)3.69618757
49negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.67634280
50nucleoside transmembrane transport (GO:1901642)3.63344206
51tRNA modification (GO:0006400)3.62154008
52sensory perception of smell (GO:0007608)3.60881867
53lens fiber cell differentiation (GO:0070306)3.59043909
54glycerophospholipid catabolic process (GO:0046475)3.56139902
55purinergic receptor signaling pathway (GO:0035587)3.54615063
56ventricular system development (GO:0021591)3.52862901
57water-soluble vitamin biosynthetic process (GO:0042364)3.51528028
58peristalsis (GO:0030432)3.47138642
59protein localization to cilium (GO:0061512)3.45993186
60forebrain neuron differentiation (GO:0021879)3.40561672
61negative regulation of cell cycle G2/M phase transition (GO:1902750)3.40553380
62pseudouridine synthesis (GO:0001522)3.40234672
63chaperone-mediated protein transport (GO:0072321)3.39228407
64secondary metabolite biosynthetic process (GO:0044550)3.38721478
65magnesium ion transport (GO:0015693)3.37149743
66regulation of action potential (GO:0098900)3.36100820
67cell migration in hindbrain (GO:0021535)3.34155192
68regulation of protein kinase A signaling (GO:0010738)3.34003138
69protein palmitoylation (GO:0018345)3.32893409
70melanin metabolic process (GO:0006582)3.32411864
71adenine nucleotide transport (GO:0051503)3.31311572
72negative regulation of telomere maintenance (GO:0032205)3.28540202
73synaptic transmission, cholinergic (GO:0007271)3.27487394
74urogenital system development (GO:0001655)3.24829090
75detection of light stimulus involved in visual perception (GO:0050908)3.21233400
76detection of light stimulus involved in sensory perception (GO:0050962)3.21233400
77phenol-containing compound catabolic process (GO:0019336)3.19281817
78calcium-mediated signaling using intracellular calcium source (GO:0035584)3.19135669
79DNA deamination (GO:0045006)3.18678256
80cell fate commitment involved in formation of primary germ layer (GO:0060795)3.16862123
81nucleotide transmembrane transport (GO:1901679)3.15910727
82purine ribonucleotide transport (GO:0015868)3.15466440
83protein insertion into membrane (GO:0051205)3.13999191
84mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.13886485
85regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.12866872
863-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.12523442
87purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.12523442
88response to pheromone (GO:0019236)3.11604180
89glycolipid biosynthetic process (GO:0009247)3.08976449
90rRNA methylation (GO:0031167)3.07254569
91regulation of MHC class I biosynthetic process (GO:0045343)3.06188185
92regulation of cilium movement (GO:0003352)3.04268483
93mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.03910838
94mitochondrial respiratory chain complex I assembly (GO:0032981)3.03910838
95NADH dehydrogenase complex assembly (GO:0010257)3.03910838
96base-excision repair, AP site formation (GO:0006285)3.03715879
97vocalization behavior (GO:0071625)3.03253865
98myelin maintenance (GO:0043217)3.01072528
99respiratory chain complex IV assembly (GO:0008535)2.99649932
100protein complex biogenesis (GO:0070271)2.99440779
101protein neddylation (GO:0045116)2.97557594
102startle response (GO:0001964)2.97356805
103negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.95677873
104establishment of protein localization to mitochondrial membrane (GO:0090151)2.94133252
105transmission of nerve impulse (GO:0019226)2.92827336
106ionotropic glutamate receptor signaling pathway (GO:0035235)2.91361029
107cardiovascular system development (GO:0072358)2.91232103
108sialylation (GO:0097503)2.90395475
109regulation of mammary gland epithelial cell proliferation (GO:0033599)2.88664143
110cerebral cortex radially oriented cell migration (GO:0021799)2.88361401
111GPI anchor biosynthetic process (GO:0006506)2.86597074
112negative regulation of macrophage differentiation (GO:0045650)2.85422189
113long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.84864904
114DNA damage response, detection of DNA damage (GO:0042769)2.84524717
115long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.84420194
116preassembly of GPI anchor in ER membrane (GO:0016254)2.82398214
117histone H2B ubiquitination (GO:0033523)2.82034070
118negative regulation of protein localization to cell surface (GO:2000009)2.81538667
119negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.81492802
120detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.81388971
121detection of temperature stimulus involved in sensory perception (GO:0050961)2.81388971
122positive regulation of TOR signaling (GO:0032008)2.80265101
123electron transport chain (GO:0022900)2.78931529
124mitochondrial respiratory chain complex assembly (GO:0033108)2.77231151
125GPI anchor metabolic process (GO:0006505)2.77076853
126cytochrome complex assembly (GO:0017004)2.75779603
127mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.75166038
128fucose catabolic process (GO:0019317)2.74909061
129L-fucose metabolic process (GO:0042354)2.74909061
130L-fucose catabolic process (GO:0042355)2.74909061
131cellular anion homeostasis (GO:0030002)2.74652967
132somite rostral/caudal axis specification (GO:0032525)2.73055963
133astrocyte development (GO:0014002)2.72957673
134tRNA processing (GO:0008033)2.72733199
135positive regulation of action potential (GO:0045760)2.72087247
136termination of RNA polymerase III transcription (GO:0006386)2.71122649
137transcription elongation from RNA polymerase III promoter (GO:0006385)2.71122649
138anatomical structure regression (GO:0060033)2.70260262
139ATP synthesis coupled proton transport (GO:0015986)2.69983397
140energy coupled proton transport, down electrochemical gradient (GO:0015985)2.69983397
141activation of adenylate cyclase activity (GO:0007190)2.69949895
142protein import into peroxisome matrix (GO:0016558)2.69922235
143negative regulation of neurotransmitter transport (GO:0051589)2.69609777
144positive regulation of synapse assembly (GO:0051965)2.69061232
145respiratory electron transport chain (GO:0022904)2.68595340
146substantia nigra development (GO:0021762)2.68088531
147rRNA modification (GO:0000154)2.67800394
148negative regulation of T cell differentiation in thymus (GO:0033085)2.67482995
149regulation of neuron projection regeneration (GO:0070570)2.67220019
150regulation of axon regeneration (GO:0048679)2.67220019
151cerebral cortex neuron differentiation (GO:0021895)2.67101835
152positive regulation of catecholamine secretion (GO:0033605)2.66468751
153membrane assembly (GO:0071709)2.65236860
154dendritic spine morphogenesis (GO:0060997)2.64541242
155phosphatidylserine acyl-chain remodeling (GO:0036150)2.63765965
156ribosomal small subunit biogenesis (GO:0042274)2.63637554
157activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.63621033
158mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.63538488
159coenzyme catabolic process (GO:0009109)2.62170659
160cullin deneddylation (GO:0010388)2.62168578
161phosphatidylglycerol biosynthetic process (GO:0006655)2.61480215
162G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.60795113
163iron-sulfur cluster assembly (GO:0016226)2.59915631
164metallo-sulfur cluster assembly (GO:0031163)2.59915631
165synaptic transmission, glutamatergic (GO:0035249)2.58638325
166negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.58512693
167spinal cord motor neuron differentiation (GO:0021522)2.55799224
168cranial nerve development (GO:0021545)2.54323585
169sex differentiation (GO:0007548)2.54123129
170isoprenoid biosynthetic process (GO:0008299)2.53455177
171cerebellar granule cell differentiation (GO:0021707)2.52656973
172nephron tubule morphogenesis (GO:0072078)2.52291361
173nephron epithelium morphogenesis (GO:0072088)2.52291361
174microtubule severing (GO:0051013)2.52184649
175arachidonic acid secretion (GO:0050482)2.51731323
176icosanoid secretion (GO:0032309)2.51731323
177reciprocal DNA recombination (GO:0035825)2.51680664
178reciprocal meiotic recombination (GO:0007131)2.51680664
179axoneme assembly (GO:0035082)2.51645176
180GDP-mannose metabolic process (GO:0019673)2.51628783
181regulation of respiratory gaseous exchange (GO:0043576)2.51603094
182neuron recognition (GO:0008038)2.51196712
183purine nucleotide transport (GO:0015865)2.50957179
184UV protection (GO:0009650)2.50757473
185regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.50741602
186lateral sprouting from an epithelium (GO:0060601)2.50658370
187regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.50124086
188positive regulation of heat generation (GO:0031652)2.49964894
189sphingoid metabolic process (GO:0046519)2.49023762

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.05368916
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.05368916
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.05368916
4EZH2_22144423_ChIP-Seq_EOC_Human3.96964301
5VDR_22108803_ChIP-Seq_LS180_Human3.29413017
6VDR_21846776_ChIP-Seq_THP-1_Human3.13383922
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.05510179
8CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human3.02068051
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.90705621
10IGF1R_20145208_ChIP-Seq_DFB_Human2.89481406
11P68_20966046_ChIP-Seq_HELA_Human2.77761480
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.60645259
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.60327547
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.52637298
15GBX2_23144817_ChIP-Seq_PC3_Human2.47096127
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46836761
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46836761
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.45809758
19CTCF_27219007_Chip-Seq_Bcells_Human2.44217874
20XRN2_22483619_ChIP-Seq_HELA_Human2.42195599
21BCL6_27268052_Chip-Seq_Bcells_Human2.38734831
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.34808922
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.32067148
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24177454
25LXR_22292898_ChIP-Seq_THP-1_Human2.23633710
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.23466502
27E2F1_20622854_ChIP-Seq_HELA_Human2.23326668
28BCOR_27268052_Chip-Seq_Bcells_Human2.19465160
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19353385
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.17531209
31JARID2_20075857_ChIP-Seq_MESCs_Mouse2.14288631
32BMI1_23680149_ChIP-Seq_NPCS_Mouse2.13941815
33PHF8_20622854_ChIP-Seq_HELA_Human2.11072886
34MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human2.10936838
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.04562386
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.02226743
37EED_16625203_ChIP-ChIP_MESCs_Mouse2.02023513
38RNF2_27304074_Chip-Seq_NSC_Mouse2.00732722
39TET1_21451524_ChIP-Seq_MESCs_Mouse1.95313457
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.94060492
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.92581102
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.91652217
43CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.91327216
44ERA_21632823_ChIP-Seq_H3396_Human1.90541638
45SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.88971823
46SRY_22984422_ChIP-ChIP_TESTIS_Rat1.87714005
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.86287139
48FOXP1_21924763_ChIP-Seq_HESCs_Human1.85520814
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.84551374
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.84406175
51MAF_26560356_Chip-Seq_TH2_Human1.82473086
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.79212713
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79136683
54RARB_24833708_ChIP-Seq_LIVER_Mouse1.77968935
55TAF15_26573619_Chip-Seq_HEK293_Human1.76750798
56NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.75077729
57RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.74774740
58SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.72413198
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.72309461
60EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.72236068
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69623563
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.68710639
63MTF2_20144788_ChIP-Seq_MESCs_Mouse1.66359008
64RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.64911645
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.64118398
66CTCF_20526341_ChIP-Seq_ESCs_Human1.63760133
67SMC4_20622854_ChIP-Seq_HELA_Human1.61278084
68ELF1_20517297_ChIP-Seq_JURKAT_Human1.60647699
69SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.59890389
70RING1B_27294783_Chip-Seq_NPCs_Mouse1.57435187
71SUZ12_27294783_Chip-Seq_ESCs_Mouse1.56864869
72SA1_27219007_Chip-Seq_ERYTHROID_Human1.55352491
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54599519
74SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.54334866
75RARA_24833708_ChIP-Seq_LIVER_Mouse1.53655747
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.51725903
77ETS1_20019798_ChIP-Seq_JURKAT_Human1.50591408
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48028291
79SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.47946383
80STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.47275600
81CTCF_27219007_Chip-Seq_ERYTHROID_Human1.44139062
82TP63_19390658_ChIP-ChIP_HaCaT_Human1.41308374
83IRF1_19129219_ChIP-ChIP_H3396_Human1.40956236
84SA1_27219007_Chip-Seq_Bcells_Human1.40366130
85FUS_26573619_Chip-Seq_HEK293_Human1.39648532
86OCT4_19829295_ChIP-Seq_ESCs_Human1.38194203
87THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36437146
88RXRA_24833708_ChIP-Seq_LIVER_Mouse1.35738725
89TAF2_19829295_ChIP-Seq_ESCs_Human1.35288557
90CTCF_21964334_Chip-Seq_Bcells_Human1.34154185
91NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.33740630
92TCF3_18692474_ChIP-Seq_MESCs_Mouse1.31835345
93P53_21459846_ChIP-Seq_SAOS-2_Human1.31557452
94ERG_21242973_ChIP-ChIP_JURKAT_Human1.31309303
95FLI1_27457419_Chip-Seq_LIVER_Mouse1.31304665
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30934664
97IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30467272
98CTCF_21964334_ChIP-Seq_BJAB-B_Human1.27201370
99CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27164419
100P300_27268052_Chip-Seq_Bcells_Human1.24545514
101MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24321442
102GABP_17652178_ChIP-ChIP_JURKAT_Human1.23931442
103REST_21632747_ChIP-Seq_MESCs_Mouse1.23321199
104ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23165904
105SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.23158387
106RACK7_27058665_Chip-Seq_MCF-7_Human1.21897237
107KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20677402
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20643875
109GABP_19822575_ChIP-Seq_HepG2_Human1.20396107
110VDR_24763502_ChIP-Seq_THP-1_Human1.20356877
111GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20233024
112RING1B_27294783_Chip-Seq_ESCs_Mouse1.20193833
113NANOG_20526341_ChIP-Seq_ESCs_Human1.19671559
114TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.18727080
115CTCF_26484167_Chip-Seq_Bcells_Mouse1.18420331
116EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18052431
117BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17924201
118PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17695712
119GATA1_26923725_Chip-Seq_HPCs_Mouse1.17414837
120CREB1_26743006_Chip-Seq_LNCaP_Human1.15905527
121FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14832635
122OCT4_20526341_ChIP-Seq_ESCs_Human1.14761225
123DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14229074
124SOX2_16153702_ChIP-ChIP_HESCs_Human1.14223278
125TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12374058
126CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11631488
127MAF_26560356_Chip-Seq_TH1_Human1.11062241
128TP53_22127205_ChIP-Seq_IMR90_Human1.10665235
129VDR_23849224_ChIP-Seq_CD4+_Human1.10162018
130DCP1A_22483619_ChIP-Seq_HELA_Human1.10115016
131RARB_27405468_Chip-Seq_BRAIN_Mouse1.09179705
132NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.09081740
133SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08996770
134PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08934900
135CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.08408735
136TP53_20018659_ChIP-ChIP_R1E_Mouse1.08027002
137TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07980658
138TDRD3_21172665_ChIP-Seq_MCF-7_Human1.07781695
139POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07124101
140TP53_22573176_ChIP-Seq_HFKS_Human1.06676430
141RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05432543
142SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04839469
143GATA3_21867929_ChIP-Seq_CD8_Mouse1.04622932
144KDM2B_26808549_Chip-Seq_DND41_Human1.04180474
145E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04015826
146PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02399560
147NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.02020613
148CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01248358
149ZNF274_21170338_ChIP-Seq_K562_Hela1.01072916
150TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.99543966
151CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99462714
152POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98953194
153REST_18959480_ChIP-ChIP_MESCs_Mouse0.97116963
154E2F1_17053090_ChIP-ChIP_MCF-7_Human0.95910651
155SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95636815
156KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94417955
157KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.92694898
158HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.90355819
159UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87295567
160PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.86950914
161STAT1_20625510_ChIP-Seq_HELA_Human0.86521106
162SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.86259214
163ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.85969285
164PIAS1_25552417_ChIP-Seq_VCAP_Human0.84854697
165CMYC_18555785_Chip-Seq_ESCs_Mouse0.84534599
166TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83759374
167POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83759374
168SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83518316
169SMAD3_21741376_ChIP-Seq_EPCs_Human0.83324253
170TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82559126
171GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.82297647
172MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.82218421
173PCGF2_27294783_Chip-Seq_ESCs_Mouse0.81170697
174TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.80486693
175PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.80415506
176HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.79344205
177SUZ12_18555785_Chip-Seq_ESCs_Mouse0.79152530
178YY1_22570637_ChIP-Seq_MALME-3M_Human0.77820800
179ETV2_25802403_ChIP-Seq_MESCs_Mouse0.77263936
180TAL1_26923725_Chip-Seq_HPCs_Mouse0.77103738
181POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.77007554
182P300_18555785_Chip-Seq_ESCs_Mouse0.75971420

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005174_abnormal_tail_pigmentation4.63734289
2MP0001188_hyperpigmentation3.93250647
3MP0003880_abnormal_central_pattern3.27866577
4MP0005394_taste/olfaction_phenotype3.09186183
5MP0005499_abnormal_olfactory_system3.09186183
6MP0001984_abnormal_olfaction2.97444122
7MP0003011_delayed_dark_adaptation2.82721782
8MP0006292_abnormal_olfactory_placode2.82058602
9MP0004858_abnormal_nervous_system2.70673917
10MP0002736_abnormal_nociception_after2.70502203
11MP0008057_abnormal_DNA_replication2.68878198
12MP0000920_abnormal_myelination2.63210952
13MP0002638_abnormal_pupillary_reflex2.60232922
14MP0004270_analgesia2.51138722
15MP0001529_abnormal_vocalization2.33302354
16MP0003122_maternal_imprinting2.25816625
17MP0002272_abnormal_nervous_system2.23596156
18MP0001968_abnormal_touch/_nociception2.22221545
19MP0008789_abnormal_olfactory_epithelium2.21126301
20MP0003938_abnormal_ear_development2.12587368
21MP0001486_abnormal_startle_reflex2.12507007
22MP0003136_yellow_coat_color2.06151657
23MP0005171_absent_coat_pigmentation2.02796959
24MP0009379_abnormal_foot_pigmentation2.01354265
25MP0001502_abnormal_circadian_rhythm1.99199154
26MP0004859_abnormal_synaptic_plasticity1.85910837
27MP0000778_abnormal_nervous_system1.84073108
28MP0002064_seizures1.81330478
29MP0001661_extended_life_span1.76082178
30MP0002734_abnormal_mechanical_nocicepti1.72425654
31MP0004142_abnormal_muscle_tone1.71965385
32MP0000015_abnormal_ear_pigmentation1.69494153
33MP0003123_paternal_imprinting1.67305846
34MP0005409_darkened_coat_color1.66895156
35MP0003635_abnormal_synaptic_transmissio1.64543783
36MP0005645_abnormal_hypothalamus_physiol1.62050287
37MP0001756_abnormal_urination1.61972877
38MP0002160_abnormal_reproductive_system1.61799887
39MP0000049_abnormal_middle_ear1.61194575
40MP0002277_abnormal_respiratory_mucosa1.61106920
41MP0002572_abnormal_emotion/affect_behav1.59207309
42MP0000538_abnormal_urinary_bladder1.58724094
43MP0005551_abnormal_eye_electrophysiolog1.58383623
44MP0002733_abnormal_thermal_nociception1.56380293
45MP0001986_abnormal_taste_sensitivity1.55748709
46MP0004742_abnormal_vestibular_system1.55285707
47MP0010386_abnormal_urinary_bladder1.55274755
48MP0005083_abnormal_biliary_tract1.52859115
49MP0009745_abnormal_behavioral_response1.52792190
50MP0002233_abnormal_nose_morphology1.47541134
51MP0005075_abnormal_melanosome_morpholog1.47172828
52MP0001905_abnormal_dopamine_level1.46245347
53MP0008875_abnormal_xenobiotic_pharmacok1.46102652
54MP0003890_abnormal_embryonic-extraembry1.41518589
55MP0005423_abnormal_somatic_nervous1.40319490
56MP0004133_heterotaxia1.39563271
57MP0002332_abnormal_exercise_endurance1.38410090
58MP0004381_abnormal_hair_follicle1.37908564
59MP0001970_abnormal_pain_threshold1.37780701
60MP0002735_abnormal_chemical_nociception1.36282271
61MP0001485_abnormal_pinna_reflex1.35254168
62MP0006276_abnormal_autonomic_nervous1.33916523
63MP0002752_abnormal_somatic_nervous1.33500669
64MP0002063_abnormal_learning/memory/cond1.32796008
65MP0002184_abnormal_innervation1.29587490
66MP0009046_muscle_twitch1.29544674
67MP0006072_abnormal_retinal_apoptosis1.29477644
68MP0001440_abnormal_grooming_behavior1.28684761
69MP0000678_abnormal_parathyroid_gland1.27090679
70MP0000762_abnormal_tongue_morphology1.26319994
71MP0003634_abnormal_glial_cell1.24323333
72MP0002132_abnormal_respiratory_system1.21966968
73MP0000631_abnormal_neuroendocrine_gland1.21953293
74MP0000955_abnormal_spinal_cord1.21916324
75MP0002882_abnormal_neuron_morphology1.21855988
76MP0002067_abnormal_sensory_capabilities1.19090668
77MP0008995_early_reproductive_senescence1.18041836
78MP0001963_abnormal_hearing_physiology1.17968824
79MP0000026_abnormal_inner_ear1.14627731
80MP0004130_abnormal_muscle_cell1.13419215
81MP0002653_abnormal_ependyma_morphology1.13395574
82MP0003755_abnormal_palate_morphology1.12968755
83MP0005084_abnormal_gallbladder_morpholo1.12520890
84MP0003941_abnormal_skin_development1.12016556
85MP0003787_abnormal_imprinting1.08132640
86MP0005389_reproductive_system_phenotype1.07895639
87MP0002751_abnormal_autonomic_nervous1.07537332
88MP0005408_hypopigmentation1.05376271
89MP0000750_abnormal_muscle_regeneration1.04764510
90MP0003690_abnormal_glial_cell1.04690054
91MP0005332_abnormal_amino_acid1.04344395
92MP0003878_abnormal_ear_physiology1.03661643
93MP0005377_hearing/vestibular/ear_phenot1.03661643
94MP0010030_abnormal_orbit_morphology1.03324429
95MP0005253_abnormal_eye_physiology1.02083488
96MP0004043_abnormal_pH_regulation1.01775457
97MP0002557_abnormal_social/conspecific_i1.00409321
98MP0003879_abnormal_hair_cell0.99181590
99MP0004019_abnormal_vitamin_homeostasis0.98737412
100MP0004272_abnormal_basement_membrane0.98082563
101MP0003693_abnormal_embryo_hatching0.98048872
102MP0002254_reproductive_system_inflammat0.97252744
103MP0005257_abnormal_intraocular_pressure0.97156321
104MP0009250_abnormal_appendicular_skeleto0.95902111
105MP0002249_abnormal_larynx_morphology0.95465454
106MP0005646_abnormal_pituitary_gland0.94818356
107MP0005195_abnormal_posterior_eye0.94689934
108MP0002066_abnormal_motor_capabilities/c0.93361506
109MP0001919_abnormal_reproductive_system0.92367235
110MP0003121_genomic_imprinting0.92121248
111MP0006035_abnormal_mitochondrial_morpho0.90304812
112MP0000013_abnormal_adipose_tissue0.89927987
113MP0008872_abnormal_physiological_respon0.88802658
114MP0002229_neurodegeneration0.88151954
115MP0005410_abnormal_fertilization0.87572436
116MP0008877_abnormal_DNA_methylation0.85423796
117MP0004885_abnormal_endolymph0.85335132
118MP0002909_abnormal_adrenal_gland0.84078736
119MP0008932_abnormal_embryonic_tissue0.84009466
120MP0002837_dystrophic_cardiac_calcinosis0.83295471
121MP0003861_abnormal_nervous_system0.81399900
122MP0003119_abnormal_digestive_system0.80411384
123MP0003806_abnormal_nucleotide_metabolis0.79447296
124MP0005391_vision/eye_phenotype0.78715374
125MP0002932_abnormal_joint_morphology0.78396385
126MP0001293_anophthalmia0.78333329
127MP0002152_abnormal_brain_morphology0.78219033
128MP0003315_abnormal_perineum_morphology0.78174914
129MP0002210_abnormal_sex_determination0.78147463
130MP0003137_abnormal_impulse_conducting0.77389079
131MP0000470_abnormal_stomach_morphology0.77273221
132MP0005266_abnormal_metabolism0.77173441
133MP0002098_abnormal_vibrissa_morphology0.77068669
134MP0003283_abnormal_digestive_organ0.77000137
135MP0002102_abnormal_ear_morphology0.76876203
136MP0002928_abnormal_bile_duct0.76824678
137MP0000647_abnormal_sebaceous_gland0.76260910
138MP0004924_abnormal_behavior0.75846498
139MP0005386_behavior/neurological_phenoty0.75846498
140MP0005365_abnormal_bile_salt0.75748730
141MP0001346_abnormal_lacrimal_gland0.75746375
142MP0001765_abnormal_ion_homeostasis0.75472595
143MP0003632_abnormal_nervous_system0.74497873
144MP0001501_abnormal_sleep_pattern0.71339982
145MP0001664_abnormal_digestion0.69677438
146MP0005167_abnormal_blood-brain_barrier0.67320811
147MP0009384_cardiac_valve_regurgitation0.66046562
148MP0003111_abnormal_nucleus_morphology0.63805961
149MP0000751_myopathy0.57171734

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)5.11763086
2Bilateral microphthalmos (HP:0007633)4.53763867
33-Methylglutaconic aciduria (HP:0003535)4.20384068
4Attenuation of retinal blood vessels (HP:0007843)4.17808798
5Partial duplication of thumb phalanx (HP:0009944)4.02259018
6Hypochromic microcytic anemia (HP:0004840)3.91470616
7Retinal dysplasia (HP:0007973)3.78112537
8Sensory axonal neuropathy (HP:0003390)3.66767955
9Turricephaly (HP:0000262)3.66007009
10Rib fusion (HP:0000902)3.57961970
11Akinesia (HP:0002304)3.52657567
12Patellar aplasia (HP:0006443)3.51296991
13Poikiloderma (HP:0001029)3.50386780
14Nasolacrimal duct obstruction (HP:0000579)3.49452058
15Annular pancreas (HP:0001734)3.47948064
16Hyperventilation (HP:0002883)3.42360661
17Bony spicule pigmentary retinopathy (HP:0007737)3.42101001
18Partial duplication of the phalanx of hand (HP:0009999)3.41230063
19Abnormal number of erythroid precursors (HP:0012131)3.41097173
20Aplasia/Hypoplasia of the patella (HP:0006498)3.41026995
21Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.25292259
22Coronal craniosynostosis (HP:0004440)3.13624179
23Chorioretinal atrophy (HP:0000533)3.10776138
24Anomalous pulmonary venous return (HP:0010772)3.09265214
25Polydipsia (HP:0001959)3.06594154
26Abnormal drinking behavior (HP:0030082)3.06594154
27Renal Fanconi syndrome (HP:0001994)3.01153582
28Abnormality of cells of the erythroid lineage (HP:0012130)2.99529658
29Focal motor seizures (HP:0011153)2.98057821
30Bifid tongue (HP:0010297)2.96527983
31Facial hemangioma (HP:0000329)2.93600060
32Birth length less than 3rd percentile (HP:0003561)2.93557005
33Absent thumb (HP:0009777)2.91329983
34Thin bony cortex (HP:0002753)2.90962658
35Mesangial abnormality (HP:0001966)2.85799535
36Abnormality of the pulmonary veins (HP:0011718)2.85569545
37Acute necrotizing encephalopathy (HP:0006965)2.84510039
38Abnormality of the lacrimal duct (HP:0011481)2.81745673
39Synostosis involving the elbow (HP:0003938)2.80752552
40Humeroradial synostosis (HP:0003041)2.80752552
41Periauricular skin pits (HP:0100277)2.79098693
42Preauricular pit (HP:0004467)2.79098693
43Pendular nystagmus (HP:0012043)2.72241057
44Squamous cell carcinoma (HP:0002860)2.71720926
45Generalized hypotonia (HP:0001290)2.70134464
46Fetal akinesia sequence (HP:0001989)2.69485679
47Short chin (HP:0000331)2.68827491
48Parakeratosis (HP:0001036)2.60884979
49Hypoalbuminemia (HP:0003073)2.58973966
50Abnormal albumin level (HP:0012116)2.58973966
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.58840043
52Hypoplasia of the pons (HP:0012110)2.57995841
53Abnormality of the nasolacrimal system (HP:0000614)2.57788744
54Rectovaginal fistula (HP:0000143)2.56135306
55Rectal fistula (HP:0100590)2.56135306
56Abnormal lung lobation (HP:0002101)2.55489637
57Testicular atrophy (HP:0000029)2.53641262
58Mitochondrial inheritance (HP:0001427)2.52978940
59Facial diplegia (HP:0001349)2.50378325
60Fused cervical vertebrae (HP:0002949)2.47795548
61Decreased central vision (HP:0007663)2.47644537
62Progressive macrocephaly (HP:0004481)2.46622167
63Homocystinuria (HP:0002156)2.46098967
64Abnormality of homocysteine metabolism (HP:0010919)2.46098967
65Symphalangism affecting the phalanges of the hand (HP:0009773)2.45952962
66Abnormality of the corticospinal tract (HP:0002492)2.45422067
67Atonic seizures (HP:0010819)2.44459248
68Ulnar bowing (HP:0003031)2.43829119
69Myokymia (HP:0002411)2.42432198
70Nephronophthisis (HP:0000090)2.41319445
71Polyuria (HP:0000103)2.40701087
72Hepatoblastoma (HP:0002884)2.40541590
73Aplasia of the musculature (HP:0100854)2.40089428
74Abnormality of the pons (HP:0007361)2.39701522
75Diastasis recti (HP:0001540)2.38992113
76Increased hepatocellular lipid droplets (HP:0006565)2.38345049
77Acute encephalopathy (HP:0006846)2.36283479
78Cerebral hypomyelination (HP:0006808)2.36023031
79Delayed epiphyseal ossification (HP:0002663)2.35423374
80Split foot (HP:0001839)2.34204660
81Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.33927755
82Vaginal fistula (HP:0004320)2.29341635
83Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.28464399
84Abnormal mitochondria in muscle tissue (HP:0008316)2.27761093
85Male pseudohermaphroditism (HP:0000037)2.26324403
86Dyschromatopsia (HP:0007641)2.26255395
87Nephroblastoma (Wilms tumor) (HP:0002667)2.26193284
88Male infertility (HP:0003251)2.26153017
89Decreased electroretinogram (ERG) amplitude (HP:0000654)2.25807561
90Abnormal pupillary function (HP:0007686)2.25634763
91Methylmalonic aciduria (HP:0012120)2.25393695
92Duplication of thumb phalanx (HP:0009942)2.25222717
93Decreased circulating renin level (HP:0003351)2.24832137
94Neurofibrillary tangles (HP:0002185)2.22527474
95Abnormality of the phalanges of the hallux (HP:0010057)2.21894241
96Abnormal hair whorl (HP:0010721)2.19604013
97Amblyopia (HP:0000646)2.18654494
98Popliteal pterygium (HP:0009756)2.18636695
99Confusion (HP:0001289)2.18223080
100Enlarged epiphyses (HP:0010580)2.17464863
101Concave nail (HP:0001598)2.17325387
102Hypoplasia of the radius (HP:0002984)2.16940200
103Tubular atrophy (HP:0000092)2.14550770
104Abnormality of midbrain morphology (HP:0002418)2.13723204
105Molar tooth sign on MRI (HP:0002419)2.13723204
106Chronic hepatic failure (HP:0100626)2.13636222
107Leukodystrophy (HP:0002415)2.09269424
108Absent septum pellucidum (HP:0001331)2.09020386
109True hermaphroditism (HP:0010459)2.08153776
110Horizontal nystagmus (HP:0000666)2.08109664
111Abnormality of the septum pellucidum (HP:0007375)2.04868877
112Increased intramyocellular lipid droplets (HP:0012240)2.03330389
113Short thumb (HP:0009778)2.03198026
114Embryonal renal neoplasm (HP:0011794)2.02785990
115Breast hypoplasia (HP:0003187)2.02761034
116Methylmalonic acidemia (HP:0002912)2.02503234
117Aplasia/Hypoplasia involving the musculature (HP:0001460)2.02445860
118Hyperinsulinemic hypoglycemia (HP:0000825)2.00283250
119Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.99823487
120Hypothermia (HP:0002045)1.99725650
121Abnormal urine output (HP:0012590)1.99443872
122Anteriorly placed anus (HP:0001545)1.98169407
123Abnormality of the fovea (HP:0000493)1.97263811
124Aplasia/hypoplasia of the uterus (HP:0008684)1.97219771
125Epileptic encephalopathy (HP:0200134)1.95912752
126Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.95700259
127Increased CSF lactate (HP:0002490)1.93982389
128Premature graying of hair (HP:0002216)1.93963509
129Abnormal hemoglobin (HP:0011902)1.93689366
130Dialeptic seizures (HP:0011146)1.93620034
131Abnormality of the salivary glands (HP:0010286)1.93392832
132Ectopic anus (HP:0004397)1.91321547
133Lipid accumulation in hepatocytes (HP:0006561)1.89934532
134Hepatocellular necrosis (HP:0001404)1.88898075
135Chin dimple (HP:0010751)1.87573865
136Increased muscle lipid content (HP:0009058)1.87342023
137Inability to walk (HP:0002540)1.87276671
138Flat occiput (HP:0005469)1.85550965
139Abnormality of placental membranes (HP:0011409)1.85531285
140Amniotic constriction ring (HP:0009775)1.85531285
141Aplasia/Hypoplasia of the fovea (HP:0008060)1.84800572
142Hypoplasia of the fovea (HP:0007750)1.84800572
143Degeneration of the lateral corticospinal tracts (HP:0002314)1.84524448
144Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.84524448
145Optic disc pallor (HP:0000543)1.83929214
146Skin pits (HP:0100276)1.83735241
147Bowed forearm bones (HP:0003956)1.83372898
148Bowing of the arm (HP:0006488)1.83372898
149Abnormality of renal resorption (HP:0011038)1.82771790
150Intestinal fistula (HP:0100819)1.82720050
151Hypoplastic pelvis (HP:0008839)1.82675729
152Hypochromic anemia (HP:0001931)1.82559200
153Abnormality of the renal medulla (HP:0100957)1.81809466
154Chromosomal breakage induced by crosslinking agents (HP:0003221)1.81532351
155Morphological abnormality of the middle ear (HP:0008609)1.80101864
156Type 2 muscle fiber atrophy (HP:0003554)1.78739718
157Tachypnea (HP:0002789)1.78650313
158Joint stiffness (HP:0001387)1.77891699
159Hypoplastic heart (HP:0001961)1.77591083
160Relative macrocephaly (HP:0004482)1.77029100
161Abnormality of the costochondral junction (HP:0000919)1.76690495
162Stenosis of the external auditory canal (HP:0000402)1.75129830
163Myotonia (HP:0002486)1.75052224
164Narrow nasal bridge (HP:0000446)1.75005415
165Pancreatic cysts (HP:0001737)1.74245378
166Abnormality of secondary sexual hair (HP:0009888)1.73782007
167Abnormality of the axillary hair (HP:0100134)1.73782007
168Hypophosphatemic rickets (HP:0004912)1.73031900
169Abnormal rod and cone electroretinograms (HP:0008323)1.72685635
170Increased number of teeth (HP:0011069)1.72537763
171Septo-optic dysplasia (HP:0100842)1.71660876
172Aplasia/Hypoplasia affecting the retina (HP:0008061)1.70483906
173Abnormal ciliary motility (HP:0012262)1.69268910
174Abnormality of the pupil (HP:0000615)1.69029876
175Broad foot (HP:0001769)1.67748924
176Peripheral hypomyelination (HP:0007182)1.66892430
177Abnormal auditory evoked potentials (HP:0006958)1.66891932
178Increased serum pyruvate (HP:0003542)1.63041840
179Abnormality of glycolysis (HP:0004366)1.63041840

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK195.94608880
2MAPK155.84538745
3GRK54.63004032
4ADRBK23.27901917
5ZAK3.27338920
6GRK63.18484447
7CASK3.01176268
8STK393.00979018
9CDK122.76795624
10GRK12.49390231
11GRK72.09346471
12OXSR12.02005197
13DAPK21.99965074
14TYRO31.95173563
15TNIK1.83936790
16EPHA41.81825430
17BLK1.81365415
18PINK11.80723719
19PDK21.80124939
20MUSK1.63349936
21TLK11.58380833
22BCR1.58373158
23TESK21.53941228
24NTRK31.48546218
25MAPKAPK51.39131739
26WNK11.38201782
27MST41.38175613
28CSNK1G31.34694132
29ACVR1B1.31020705
30WNK31.29424633
31PNCK1.26743878
32UHMK11.25923340
33CDK71.23725898
34MAP2K61.23443185
35ADRBK11.20765523
36CSF1R1.19096715
37MATK1.18509826
38STK111.18180855
39NEK61.15940815
40PAK31.15558149
41PRKD21.15102238
42NME11.13867689
43CSNK1A1L1.07074076
44FGFR21.06701834
45CAMKK11.06117890
46NTRK11.05834572
47MAPK71.05274046
48PHKG21.04027519
49PHKG11.04027519
50CSNK1G11.00179485
51NEK20.99653934
52FGR0.98684850
53RPS6KA60.95902167
54DYRK20.95517598
55VRK10.92381260
56ERN10.90409777
57FRK0.89957368
58RPS6KA20.89042821
59TGFBR20.88388481
60CSNK1G20.86633841
61DYRK1B0.84758521
62LIMK10.84455214
63NTRK20.83652712
64MAP3K100.83466697
65IRAK20.82710030
66INSRR0.82159825
67MOS0.81791473
68MET0.79786486
69TAOK30.79398632
70PDPK10.79175940
71PKN10.78402063
72YES10.78239478
73FES0.77987478
74DYRK1A0.77953776
75CAMK2B0.77398134
76CDK40.77164516
77MAPK130.77148607
78WNK40.75557653
79MARK10.73325433
80ERBB30.72032388
81CDK11A0.71466519
82BCKDK0.70958674
83STK160.69810842
84RPS6KA50.69699837
85RPS6KC10.69524195
86RPS6KL10.69524195
87PAK60.68809532
88SIK10.67749676
89PRKCI0.67015645
90MARK20.66716509
91TTK0.65780763
92MAP2K30.65647035
93EPHB10.65643513
94MAP3K90.65361381
95PBK0.65128627
96CAMK10.65075343
97PRKD10.63341805
98ERBB40.62581078
99CDK50.62484028
100EIF2AK30.61387824
101DYRK30.60880983
102CAMK40.60602289
103TNK20.58512789
104SGK2230.58131711
105SGK4940.58131711
106MAP3K110.54687141
107SRPK10.53577889
108RIPK40.52929597
109BUB10.52491248
110EPHA20.52339924
111MAP2K40.50933230
112BMPR1B0.50200481
113PRKACA0.49853386
114CDK140.49635834
115ATR0.49013905
116PRKCQ0.48739940
117PDGFRA0.48314417
118MAP4K10.47679557
119PRKCH0.47214021
120CDK180.46928059
121PLK20.45957564
122PRKD30.45931662
123CDK150.45770078
124PRKCG0.44993557
125TIE10.44960641
126CAMK2D0.44747714
127TGFBR10.44583336
128PRKCZ0.44565556
129CSNK1E0.44263209
130MAP2K70.43339258
131MAPK80.42868835
132IRAK10.42250482
133CAMK2A0.41895629
134CSNK1D0.41342994
135NUAK10.40183425
136MAP4K20.40068057
137MINK10.39198995
138IKBKB0.39096262
139TRIB30.38465743
140PRKACB0.38249759
141CSNK1A10.38087471
142TESK10.38012323
143EPHB20.37822209
144HIPK20.37575623
145SYK0.36707135
146CHEK20.36028792
147AURKA0.34207707
148PLK10.33818917
149PRKCE0.33781613
150CCNB10.33595130
151CAMK2G0.32275782
152MAP3K40.31924422
153ROCK20.31479148
154PRKAA10.31120313
155MAP2K20.31043485
156CDC70.30999329
157MAPK120.30006144
158SIK20.29251300

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006045.80781517
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.78513825
3Oxidative phosphorylation_Homo sapiens_hsa001903.67243090
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.45853704
5Vitamin B6 metabolism_Homo sapiens_hsa007502.89673017
6Ribosome_Homo sapiens_hsa030102.86442347
7Parkinsons disease_Homo sapiens_hsa050122.68539948
8Fatty acid elongation_Homo sapiens_hsa000622.67478256
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.48461282
10Alzheimers disease_Homo sapiens_hsa050102.47115442
11Ether lipid metabolism_Homo sapiens_hsa005652.45573328
12Glutamatergic synapse_Homo sapiens_hsa047242.16180478
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.11410083
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.08220387
15Linoleic acid metabolism_Homo sapiens_hsa005912.04281893
16Huntingtons disease_Homo sapiens_hsa050161.95610908
17Serotonergic synapse_Homo sapiens_hsa047261.94239991
18Nicotine addiction_Homo sapiens_hsa050331.93129897
19GABAergic synapse_Homo sapiens_hsa047271.84059827
20Arachidonic acid metabolism_Homo sapiens_hsa005901.83349406
21Cardiac muscle contraction_Homo sapiens_hsa042601.82772769
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.80452625
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.79011070
24Sphingolipid metabolism_Homo sapiens_hsa006001.77700548
25Taste transduction_Homo sapiens_hsa047421.69253735
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65152906
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.51111819
28Morphine addiction_Homo sapiens_hsa050321.49681216
29Long-term depression_Homo sapiens_hsa047301.48199634
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.46377178
31Vitamin digestion and absorption_Homo sapiens_hsa049771.37944715
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.37370382
33Histidine metabolism_Homo sapiens_hsa003401.36198049
34Olfactory transduction_Homo sapiens_hsa047401.34628507
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.32956636
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32584455
37Homologous recombination_Homo sapiens_hsa034401.30831833
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.29872363
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.27781115
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25477178
41Axon guidance_Homo sapiens_hsa043601.24136219
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23056637
43Protein export_Homo sapiens_hsa030601.20955642
44Steroid biosynthesis_Homo sapiens_hsa001001.19778753
45Collecting duct acid secretion_Homo sapiens_hsa049661.19267617
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15352775
47Hedgehog signaling pathway_Homo sapiens_hsa043401.13278322
48African trypanosomiasis_Homo sapiens_hsa051431.11867250
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09565026
50Circadian entrainment_Homo sapiens_hsa047131.07924352
51Phototransduction_Homo sapiens_hsa047440.97224884
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90864662
53Renin secretion_Homo sapiens_hsa049240.88696624
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85903665
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84733882
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80562050
57Insulin secretion_Homo sapiens_hsa049110.77926860
58Nitrogen metabolism_Homo sapiens_hsa009100.77261225
59Calcium signaling pathway_Homo sapiens_hsa040200.76712265
60Dopaminergic synapse_Homo sapiens_hsa047280.76594702
61Salivary secretion_Homo sapiens_hsa049700.74342593
62Proteasome_Homo sapiens_hsa030500.74001621
63Pyruvate metabolism_Homo sapiens_hsa006200.73969975
64Ovarian steroidogenesis_Homo sapiens_hsa049130.73057002
65Sulfur relay system_Homo sapiens_hsa041220.72328960
66Ras signaling pathway_Homo sapiens_hsa040140.72292677
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71421007
68Long-term potentiation_Homo sapiens_hsa047200.71269823
69Synaptic vesicle cycle_Homo sapiens_hsa047210.70556192
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.69101224
71RNA polymerase_Homo sapiens_hsa030200.68470228
72Basal cell carcinoma_Homo sapiens_hsa052170.68363643
73One carbon pool by folate_Homo sapiens_hsa006700.67543432
74Vibrio cholerae infection_Homo sapiens_hsa051100.66559369
75Circadian rhythm_Homo sapiens_hsa047100.66328740
76Gastric acid secretion_Homo sapiens_hsa049710.62759786
77Selenocompound metabolism_Homo sapiens_hsa004500.62591602
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.62258050
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.60790372
80Folate biosynthesis_Homo sapiens_hsa007900.60464136
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.59326338
82Gap junction_Homo sapiens_hsa045400.59150886
83Spliceosome_Homo sapiens_hsa030400.58592427
84Base excision repair_Homo sapiens_hsa034100.57723630
85Renin-angiotensin system_Homo sapiens_hsa046140.55981056
86Metabolic pathways_Homo sapiens_hsa011000.54891378
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52621258
88Cholinergic synapse_Homo sapiens_hsa047250.51043210
89Pyrimidine metabolism_Homo sapiens_hsa002400.50864296
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50672276
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50271620
92Melanogenesis_Homo sapiens_hsa049160.49293163
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49075594
94RNA degradation_Homo sapiens_hsa030180.48898151
95cAMP signaling pathway_Homo sapiens_hsa040240.48135109
96Amphetamine addiction_Homo sapiens_hsa050310.47627893
97GnRH signaling pathway_Homo sapiens_hsa049120.45841813
98Regulation of autophagy_Homo sapiens_hsa041400.45295079
99Wnt signaling pathway_Homo sapiens_hsa043100.43991834
100Purine metabolism_Homo sapiens_hsa002300.43873824
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42630319
102Chemical carcinogenesis_Homo sapiens_hsa052040.42511361
103Alcoholism_Homo sapiens_hsa050340.41969764
104Fanconi anemia pathway_Homo sapiens_hsa034600.41749746
105Basal transcription factors_Homo sapiens_hsa030220.41358328
106Choline metabolism in cancer_Homo sapiens_hsa052310.41275263
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40757844
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40335076
109Peroxisome_Homo sapiens_hsa041460.38752844
110Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38529015
111Hippo signaling pathway_Homo sapiens_hsa043900.38381159
112Mismatch repair_Homo sapiens_hsa034300.38361142
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38162245
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37779353
115Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36869789
116Fructose and mannose metabolism_Homo sapiens_hsa000510.36697085
117Arginine and proline metabolism_Homo sapiens_hsa003300.36678341
118Rap1 signaling pathway_Homo sapiens_hsa040150.36616422
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.36433458
120ABC transporters_Homo sapiens_hsa020100.35981954
121Tryptophan metabolism_Homo sapiens_hsa003800.32555169
122ErbB signaling pathway_Homo sapiens_hsa040120.31364889
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31282853
124Oxytocin signaling pathway_Homo sapiens_hsa049210.31069077
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30967499
126Sulfur metabolism_Homo sapiens_hsa009200.30751351
127Melanoma_Homo sapiens_hsa052180.30338332
128Fat digestion and absorption_Homo sapiens_hsa049750.29740448
129MAPK signaling pathway_Homo sapiens_hsa040100.29656826
130Pathways in cancer_Homo sapiens_hsa052000.28682124
131Primary immunodeficiency_Homo sapiens_hsa053400.28570149
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28000042
133Cocaine addiction_Homo sapiens_hsa050300.26903608
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26378514
135Mineral absorption_Homo sapiens_hsa049780.25101764
136Lysosome_Homo sapiens_hsa041420.24226705
137Glycerolipid metabolism_Homo sapiens_hsa005610.22976606
138Lysine degradation_Homo sapiens_hsa003100.22940185
139Cyanoamino acid metabolism_Homo sapiens_hsa004600.20694570
140Dorso-ventral axis formation_Homo sapiens_hsa043200.19483404
141Butanoate metabolism_Homo sapiens_hsa006500.16025808
142Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.14990090
143Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.13776292
144Steroid hormone biosynthesis_Homo sapiens_hsa001400.13179468

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