BRINP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.19139515
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act6.03298874
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.89821102
4vocalization behavior (GO:0071625)5.89618290
5synaptic vesicle docking involved in exocytosis (GO:0016081)5.83595848
6glutamate secretion (GO:0014047)5.69593036
7synaptic vesicle exocytosis (GO:0016079)5.57998393
8locomotory exploration behavior (GO:0035641)5.40145587
9regulation of glutamate receptor signaling pathway (GO:1900449)5.39594020
10protein localization to synapse (GO:0035418)5.34146210
11synaptic vesicle maturation (GO:0016188)5.31836282
12neuron cell-cell adhesion (GO:0007158)5.20439250
13ionotropic glutamate receptor signaling pathway (GO:0035235)5.15135119
14regulation of synaptic vesicle exocytosis (GO:2000300)5.10932531
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.08672226
16neurotransmitter-gated ion channel clustering (GO:0072578)5.05062334
17neuronal action potential propagation (GO:0019227)4.81820395
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.80210683
19glutamate receptor signaling pathway (GO:0007215)4.77735151
20synaptic transmission, glutamatergic (GO:0035249)4.66724074
21presynaptic membrane assembly (GO:0097105)4.57155636
22regulation of synaptic vesicle transport (GO:1902803)4.53899398
23positive regulation of synapse maturation (GO:0090129)4.53102577
24regulation of long-term neuronal synaptic plasticity (GO:0048169)4.50308973
25neuron-neuron synaptic transmission (GO:0007270)4.49670725
26regulation of neuronal synaptic plasticity (GO:0048168)4.42716977
27exploration behavior (GO:0035640)4.40871070
28sodium ion export (GO:0071436)4.35120825
29neurotransmitter secretion (GO:0007269)4.33417988
30regulation of excitatory postsynaptic membrane potential (GO:0060079)4.29749758
31presynaptic membrane organization (GO:0097090)4.28783046
32postsynaptic membrane organization (GO:0001941)4.28196896
33gamma-aminobutyric acid signaling pathway (GO:0007214)4.23725735
34long-term synaptic potentiation (GO:0060291)4.12239101
35regulation of postsynaptic membrane potential (GO:0060078)4.09377717
36L-amino acid import (GO:0043092)4.05726387
37negative regulation of synaptic transmission, GABAergic (GO:0032229)4.04239061
38long-term memory (GO:0007616)3.97653671
39positive regulation of membrane potential (GO:0045838)3.97305941
40cerebellar granule cell differentiation (GO:0021707)3.96076542
41regulation of synaptic plasticity (GO:0048167)3.95583737
42positive regulation of neurotransmitter secretion (GO:0001956)3.89059936
43response to histamine (GO:0034776)3.87914452
44neuron recognition (GO:0008038)3.85626129
45neuronal ion channel clustering (GO:0045161)3.81761949
46regulation of synapse structural plasticity (GO:0051823)3.81513973
47regulation of synaptic transmission, glutamatergic (GO:0051966)3.76420843
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.74031636
49regulation of dendritic spine morphogenesis (GO:0061001)3.71559537
50G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.69038989
51amino acid import (GO:0043090)3.64338889
52potassium ion homeostasis (GO:0055075)3.63896180
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.60433203
54dendritic spine morphogenesis (GO:0060997)3.59955688
55regulation of synapse maturation (GO:0090128)3.59377918
56regulation of neurotransmitter secretion (GO:0046928)3.58834299
57positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.58500007
58cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.55569800
59axonal fasciculation (GO:0007413)3.54152179
60proline transport (GO:0015824)3.53115307
61gamma-aminobutyric acid transport (GO:0015812)3.52623821
62behavioral fear response (GO:0001662)3.52311530
63behavioral defense response (GO:0002209)3.52311530
64cellular potassium ion homeostasis (GO:0030007)3.51492146
65neurotransmitter transport (GO:0006836)3.49051434
66auditory behavior (GO:0031223)3.48097187
67positive regulation of neurotransmitter transport (GO:0051590)3.46830155
68layer formation in cerebral cortex (GO:0021819)3.44936755
69potassium ion import (GO:0010107)3.42491824
70cerebellar Purkinje cell differentiation (GO:0021702)3.41498954
71fear response (GO:0042596)3.39909514
72G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.38672017
73pyrimidine nucleobase catabolic process (GO:0006208)3.37314204
74membrane depolarization (GO:0051899)3.34891813
75transmission of nerve impulse (GO:0019226)3.34759440
76synaptic vesicle endocytosis (GO:0048488)3.34037976
77cell communication by electrical coupling (GO:0010644)3.33201505
78regulation of glutamate secretion (GO:0014048)3.32990785
79regulation of vesicle fusion (GO:0031338)3.32965017
80negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.32774657
81regulation of dendritic spine development (GO:0060998)3.30873311
82activation of protein kinase A activity (GO:0034199)3.28261442
83mechanosensory behavior (GO:0007638)3.26593407
84acidic amino acid transport (GO:0015800)3.25399065
85positive regulation of synaptic transmission (GO:0050806)3.25048997
86regulation of neurotransmitter transport (GO:0051588)3.24893477
87behavioral response to cocaine (GO:0048148)3.24646241
88nucleobase catabolic process (GO:0046113)3.23953648
89regulation of neurotransmitter levels (GO:0001505)3.23487973
90learning (GO:0007612)3.23181555
91neurotransmitter uptake (GO:0001504)3.23122526
92neuromuscular synaptic transmission (GO:0007274)3.21347051
93establishment of mitochondrion localization (GO:0051654)3.21267029
94cell migration in hindbrain (GO:0021535)3.20781955
95startle response (GO:0001964)3.20183234
96serotonin metabolic process (GO:0042428)3.19166136
97regulation of synaptic transmission (GO:0050804)3.18132594
98neurofilament cytoskeleton organization (GO:0060052)3.16810818
99central nervous system myelination (GO:0022010)3.16419996
100axon ensheathment in central nervous system (GO:0032291)3.16419996
101neuromuscular process controlling balance (GO:0050885)3.13885092
102adult walking behavior (GO:0007628)3.13632072
103response to auditory stimulus (GO:0010996)3.12065348
104positive regulation of synapse assembly (GO:0051965)3.11224830
105synaptic transmission (GO:0007268)3.10902734
106negative regulation of amino acid transport (GO:0051956)3.10220791
107cochlea development (GO:0090102)3.09731094
108positive regulation of dendritic spine morphogenesis (GO:0061003)3.08716772
109neuromuscular process controlling posture (GO:0050884)3.08417223
110cellular sodium ion homeostasis (GO:0006883)3.08185266
111cell differentiation in hindbrain (GO:0021533)3.07842340
112long term synaptic depression (GO:0060292)3.06179682
113regulation of voltage-gated calcium channel activity (GO:1901385)3.04452711
114membrane hyperpolarization (GO:0060081)3.04281385
115negative regulation of dendrite morphogenesis (GO:0050774)3.02108402
116innervation (GO:0060384)3.01578149
117synapse assembly (GO:0007416)3.01346435
118regulation of female receptivity (GO:0045924)2.99723106
119dendritic spine organization (GO:0097061)2.98701762
120positive regulation of synaptic transmission, GABAergic (GO:0032230)2.98679343
121membrane depolarization during action potential (GO:0086010)2.98381184
122regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.96765081
123positive regulation of dendritic spine development (GO:0060999)2.96618454
124regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.95972130
125positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.95146277

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.06297331
2GBX2_23144817_ChIP-Seq_PC3_Human4.22069124
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.27850249
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.21574569
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.16371293
6SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.77831808
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.75455743
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.75455743
9REST_21632747_ChIP-Seq_MESCs_Mouse2.72360869
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64664347
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.64348633
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.56975924
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.56538189
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.55144119
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.50609260
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47804592
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.44682629
18DROSHA_22980978_ChIP-Seq_HELA_Human2.31092410
19TAF15_26573619_Chip-Seq_HEK293_Human2.26714215
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.20563665
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20311055
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.19606938
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.17167371
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14143887
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.03389726
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.03336221
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98469318
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96160259
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92752577
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.88930971
31RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.83609007
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.80041909
33SMAD4_21799915_ChIP-Seq_A2780_Human1.79082477
34AR_21572438_ChIP-Seq_LNCaP_Human1.78987442
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78109554
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77924779
37P300_19829295_ChIP-Seq_ESCs_Human1.62327795
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51015712
39GATA1_26923725_Chip-Seq_HPCs_Mouse1.48940639
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.48654010
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.47337394
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46649886
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45290735
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44211625
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44099656
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.41560216
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.41427008
48ZNF274_21170338_ChIP-Seq_K562_Hela1.38265891
49AR_25329375_ChIP-Seq_VCAP_Human1.38122249
50SOX2_21211035_ChIP-Seq_LN229_Gbm1.35942912
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35828723
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35251634
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35085645
54FUS_26573619_Chip-Seq_HEK293_Human1.34785527
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.31618727
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31533812
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31380434
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29552467
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29303671
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28949299
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24053952
62STAT3_23295773_ChIP-Seq_U87_Human1.23815881
63TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23524136
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.22910080
65ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18795350
66RNF2_27304074_Chip-Seq_NSC_Mouse1.17962726
67AR_19668381_ChIP-Seq_PC3_Human1.17653939
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.15950305
69TCF4_23295773_ChIP-Seq_U87_Human1.15443014
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15312730
71RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13663340
72VDR_22108803_ChIP-Seq_LS180_Human1.12069001
73PRDM14_20953172_ChIP-Seq_ESCs_Human1.07665687
74DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06550275
75AHR_22903824_ChIP-Seq_MCF-7_Human1.06202353
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06025060
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05971702
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04750643
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03916186
80LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03853183
81TP53_16413492_ChIP-PET_HCT116_Human1.03570747
82RING1B_27294783_Chip-Seq_NPCs_Mouse1.03099179
83TP53_18474530_ChIP-ChIP_U2OS_Human1.02657876
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02459695
85WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01901304
86RUNX2_22187159_ChIP-Seq_PCA_Human1.01593806
87ER_23166858_ChIP-Seq_MCF-7_Human1.01163652
88JUN_21703547_ChIP-Seq_K562_Human1.00791219
89SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98593275
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97078244
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95446347
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95446347
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95323862
94OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94945099
95NANOG_18555785_Chip-Seq_ESCs_Mouse0.94682599
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93947508
97ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93636856
98IGF1R_20145208_ChIP-Seq_DFB_Human0.93561934
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93088096
100NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93034016
101CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92541506
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91725821
103TET1_21490601_ChIP-Seq_MESCs_Mouse0.91060676
104KDM2B_26808549_Chip-Seq_REH_Human0.90507370
105SMAD3_21741376_ChIP-Seq_ESCs_Human0.90351020
106RXR_22108803_ChIP-Seq_LS180_Human0.90202330
107SOX9_26525672_Chip-Seq_HEART_Mouse0.89571185
108WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89275532
109SMAD3_21741376_ChIP-Seq_HESCs_Human0.88671287
110CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88528250
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87902934
112STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87202594
113ZFP281_27345836_Chip-Seq_ESCs_Mouse0.84859163
114KDM2B_26808549_Chip-Seq_K562_Human0.83068585
115KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.82637974
116TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.80980032
117SMAD4_21741376_ChIP-Seq_HESCs_Human0.80955760
118TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.80451849

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.65199827
2MP0003880_abnormal_central_pattern5.94013810
3MP0003635_abnormal_synaptic_transmissio4.32629072
4MP0009745_abnormal_behavioral_response3.68124676
5MP0004270_analgesia3.60575810
6MP0002063_abnormal_learning/memory/cond3.55213272
7MP0001968_abnormal_touch/_nociception3.31803119
8MP0002064_seizures3.31230210
9MP0009046_muscle_twitch3.17648809
10MP0002572_abnormal_emotion/affect_behav3.00376724
11MP0002736_abnormal_nociception_after2.77282374
12MP0002272_abnormal_nervous_system2.64181329
13MP0002822_catalepsy2.62342589
14MP0001486_abnormal_startle_reflex2.53015862
15MP0002734_abnormal_mechanical_nocicepti2.49819293
16MP0001501_abnormal_sleep_pattern2.45650878
17MP0005423_abnormal_somatic_nervous2.43092360
18MP0002735_abnormal_chemical_nociception2.42650884
19MP0001440_abnormal_grooming_behavior2.27365790
20MP0009780_abnormal_chondrocyte_physiolo2.25427374
21MP0002067_abnormal_sensory_capabilities2.09545563
22MP0003879_abnormal_hair_cell1.93514937
23MP0002733_abnormal_thermal_nociception1.93039492
24MP0001970_abnormal_pain_threshold1.87988895
25MP0003329_amyloid_beta_deposits1.81871227
26MP0000778_abnormal_nervous_system1.76548522
27MP0002557_abnormal_social/conspecific_i1.75765005
28MP0002184_abnormal_innervation1.74552057
29MP0008569_lethality_at_weaning1.73831559
30MP0004924_abnormal_behavior1.71385689
31MP0005386_behavior/neurological_phenoty1.71385689
32MP0005646_abnormal_pituitary_gland1.69369654
33MP0003787_abnormal_imprinting1.68284248
34MP0004811_abnormal_neuron_physiology1.64666122
35MP0003121_genomic_imprinting1.54650101
36MP0006276_abnormal_autonomic_nervous1.51787139
37MP0004858_abnormal_nervous_system1.46855163
38MP0002909_abnormal_adrenal_gland1.42941215
39MP0002066_abnormal_motor_capabilities/c1.40032210
40MP0001188_hyperpigmentation1.37152722
41MP0000955_abnormal_spinal_cord1.36967501
42MP0008877_abnormal_DNA_methylation1.36752989
43MP0001984_abnormal_olfaction1.35895450
44MP0003633_abnormal_nervous_system1.33941161
45MP0001529_abnormal_vocalization1.33420042
46MP0002882_abnormal_neuron_morphology1.32968384
47MP0001502_abnormal_circadian_rhythm1.32159913
48MP0001905_abnormal_dopamine_level1.27081547
49MP0003122_maternal_imprinting1.17747167
50MP0001986_abnormal_taste_sensitivity1.15108180
51MP0004142_abnormal_muscle_tone1.13877079
52MP0005645_abnormal_hypothalamus_physiol1.13033651
53MP0003631_nervous_system_phenotype1.13023428
54MP0000751_myopathy1.11412302
55MP0004885_abnormal_endolymph1.10741584
56MP0004145_abnormal_muscle_electrophysio1.09120335
57MP0002152_abnormal_brain_morphology1.04735089
58MP0002837_dystrophic_cardiac_calcinosis1.04408395
59MP0002638_abnormal_pupillary_reflex1.02823690
60MP0008872_abnormal_physiological_respon1.01720665
61MP0004742_abnormal_vestibular_system0.99908607
62MP0002102_abnormal_ear_morphology0.99256272
63MP0002876_abnormal_thyroid_physiology0.98289826
64MP0004133_heterotaxia0.93514503
65MP0008874_decreased_physiological_sensi0.93213177
66MP0002069_abnormal_eating/drinking_beha0.92393826
67MP0010386_abnormal_urinary_bladder0.89869273
68MP0001963_abnormal_hearing_physiology0.89565992
69MP0004085_abnormal_heartbeat0.84986975
70MP0005551_abnormal_eye_electrophysiolog0.83364585
71MP0002229_neurodegeneration0.82623175
72MP0000013_abnormal_adipose_tissue0.81725644
73MP0000604_amyloidosis0.80990916
74MP0005187_abnormal_penis_morphology0.77691920
75MP0005535_abnormal_body_temperature0.77469214
76MP0003075_altered_response_to0.77461186
77MP0004484_altered_response_of0.77414891
78MP0001177_atelectasis0.76326289
79MP0002653_abnormal_ependyma_morphology0.76012602
80MP0004215_abnormal_myocardial_fiber0.75959387
81MP0001299_abnormal_eye_distance/0.74643907
82MP0003632_abnormal_nervous_system0.72734929
83MP0003890_abnormal_embryonic-extraembry0.72687470
84MP0005171_absent_coat_pigmentation0.71951508
85MP0001664_abnormal_digestion0.71580081
86MP0000631_abnormal_neuroendocrine_gland0.70714708
87MP0002752_abnormal_somatic_nervous0.67247915
88MP0001485_abnormal_pinna_reflex0.66982493
89MP0000579_abnormal_nail_morphology0.65506430
90MP0000569_abnormal_digit_pigmentation0.65257036
91MP0005409_darkened_coat_color0.64945862
92MP0003690_abnormal_glial_cell0.62633451
93MP0004233_abnormal_muscle_weight0.62113270
94MP0003119_abnormal_digestive_system0.61719178
95MP0003634_abnormal_glial_cell0.61305900
96MP0004510_myositis0.61251495
97MP0005499_abnormal_olfactory_system0.58643288
98MP0005394_taste/olfaction_phenotype0.58643288
99MP0010768_mortality/aging0.57663690
100MP0000920_abnormal_myelination0.56315340
101MP0003938_abnormal_ear_development0.56253698
102MP0003283_abnormal_digestive_organ0.56038392
103MP0001943_abnormal_respiration0.55834172
104MP0004147_increased_porphyrin_level0.55097841
105MP0005623_abnormal_meninges_morphology0.53916152
106MP0003123_paternal_imprinting0.53820203
107MP0000026_abnormal_inner_ear0.53180209
108MP0003137_abnormal_impulse_conducting0.53076637
109MP0000566_synostosis0.52205565
110MP0002090_abnormal_vision0.51143650
111MP0006292_abnormal_olfactory_placode0.50764072
112MP0010769_abnormal_survival0.50733641
113MP0002081_perinatal_lethality0.50681121
114MP0002082_postnatal_lethality0.50658033
115MP0010770_preweaning_lethality0.50658033
116MP0003861_abnormal_nervous_system0.49447144
117MP0004043_abnormal_pH_regulation0.49005753
118MP0003183_abnormal_peptide_metabolism0.48555151
119MP0003956_abnormal_body_size0.48280336

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.14237644
2Myokymia (HP:0002411)6.28936099
3Focal seizures (HP:0007359)6.22418859
4Epileptic encephalopathy (HP:0200134)6.18034162
5Atonic seizures (HP:0010819)5.68273823
6Visual hallucinations (HP:0002367)5.18017960
7Hyperventilation (HP:0002883)5.13392426
8Febrile seizures (HP:0002373)4.98620878
9Absence seizures (HP:0002121)4.75376950
10Dialeptic seizures (HP:0011146)4.46446388
11Broad-based gait (HP:0002136)4.43786746
12Progressive cerebellar ataxia (HP:0002073)4.35713769
13Generalized tonic-clonic seizures (HP:0002069)4.09557658
14Gaze-evoked nystagmus (HP:0000640)3.84088796
15Poor eye contact (HP:0000817)3.76875802
16Amblyopia (HP:0000646)3.43894865
17Action tremor (HP:0002345)3.36126610
18Dysdiadochokinesis (HP:0002075)3.31999052
19Impaired social interactions (HP:0000735)3.29094038
20Abnormal social behavior (HP:0012433)3.29094038
21Impaired vibration sensation in the lower limbs (HP:0002166)3.28498069
22Drooling (HP:0002307)3.18095075
23Excessive salivation (HP:0003781)3.18095075
24Cerebral hypomyelination (HP:0006808)3.05523410
25Truncal ataxia (HP:0002078)3.05023459
26Abnormal eating behavior (HP:0100738)3.04642024
27Dysmetria (HP:0001310)3.04074975
28Urinary bladder sphincter dysfunction (HP:0002839)2.94853507
29Depression (HP:0000716)2.93013591
30Epileptiform EEG discharges (HP:0011182)2.92636044
31Abnormality of the lower motor neuron (HP:0002366)2.91678074
32Impaired smooth pursuit (HP:0007772)2.91301351
33Peripheral hypomyelination (HP:0007182)2.90102549
34Dysmetric saccades (HP:0000641)2.88217846
35Supranuclear gaze palsy (HP:0000605)2.84108196
36Protruding tongue (HP:0010808)2.81333007
37Anxiety (HP:0000739)2.78714112
38Sleep apnea (HP:0010535)2.77468692
39Scanning speech (HP:0002168)2.75315210
40Genetic anticipation (HP:0003743)2.73611397
41Absent speech (HP:0001344)2.73246671
42Stereotypic behavior (HP:0000733)2.68843230
43Postural instability (HP:0002172)2.61210595
44Ankle clonus (HP:0011448)2.60605826
45Inability to walk (HP:0002540)2.59494606
46EEG with generalized epileptiform discharges (HP:0011198)2.56733739
47Mutism (HP:0002300)2.50702664
48Cerebral inclusion bodies (HP:0100314)2.49914351
49Fetal akinesia sequence (HP:0001989)2.48297616
50Urinary urgency (HP:0000012)2.44436494
51Abnormality of ocular smooth pursuit (HP:0000617)2.43506658
52Hemiparesis (HP:0001269)2.41607059
53Status epilepticus (HP:0002133)2.41601893
54Abnormality of binocular vision (HP:0011514)2.41468156
55Diplopia (HP:0000651)2.41468156
56Insidious onset (HP:0003587)2.41355289
57Termporal pattern (HP:0011008)2.41355289
58Hypsarrhythmia (HP:0002521)2.35084571
59Impaired vibratory sensation (HP:0002495)2.35069089
60Torticollis (HP:0000473)2.34817584
61Bradykinesia (HP:0002067)2.33779631
62Spastic gait (HP:0002064)2.31537927
63Polyphagia (HP:0002591)2.30097424
64Blue irides (HP:0000635)2.26596936
65Abnormality of the corticospinal tract (HP:0002492)2.25808834
66Progressive inability to walk (HP:0002505)2.24882534
67Focal dystonia (HP:0004373)2.24662784
68Generalized myoclonic seizures (HP:0002123)2.22414144
69Abnormality of the labia minora (HP:0012880)2.20265046
70Neurofibrillary tangles (HP:0002185)2.18902886
71Abnormality of salivation (HP:0100755)2.13892421
72Failure to thrive in infancy (HP:0001531)2.13247049
73Clonus (HP:0002169)2.13007953
74Hemiplegia (HP:0002301)2.12287457
75Apathy (HP:0000741)2.11550201
76Morphological abnormality of the pyramidal tract (HP:0002062)2.10687217
77CNS hypomyelination (HP:0003429)2.10204888
78Incomplete penetrance (HP:0003829)2.07794042
79Spastic tetraplegia (HP:0002510)2.05633232
80Spastic tetraparesis (HP:0001285)2.03650666
81Delusions (HP:0000746)2.03399433
82Intention tremor (HP:0002080)2.03295534
83Gait ataxia (HP:0002066)2.00119025
84Papilledema (HP:0001085)1.99720304
85Neuronal loss in central nervous system (HP:0002529)1.99464877
86Lower limb muscle weakness (HP:0007340)1.98340181
87Annular pancreas (HP:0001734)1.96825834
88Craniofacial dystonia (HP:0012179)1.96675991
89Tetraplegia (HP:0002445)1.96125886
90Split foot (HP:0001839)1.95558900
91Gait imbalance (HP:0002141)1.93028384
92Limb dystonia (HP:0002451)1.92337585
93Thickened helices (HP:0000391)1.91635287
94Diminished motivation (HP:0000745)1.89919921
95Hyperthyroidism (HP:0000836)1.87905008
96Inappropriate behavior (HP:0000719)1.86594196
97Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.86581299
98Degeneration of the lateral corticospinal tracts (HP:0002314)1.86581299
99Amyotrophic lateral sclerosis (HP:0007354)1.85874779
100Lower limb amyotrophy (HP:0007210)1.84454277
101Cortical dysplasia (HP:0002539)1.83539973
102Generalized hypopigmentation of hair (HP:0011358)1.82538954
103Pheochromocytoma (HP:0002666)1.80381809
104Abnormality of saccadic eye movements (HP:0000570)1.77053912
105Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.76558438
106Hypoventilation (HP:0002791)1.76220045
107Specific learning disability (HP:0001328)1.75876754
108Fair hair (HP:0002286)1.75854192
109Psychosis (HP:0000709)1.74745171
110Obstructive sleep apnea (HP:0002870)1.74204660
111Esotropia (HP:0000565)1.73881844
112Hypoplasia of the corpus callosum (HP:0002079)1.73038575
113Megalencephaly (HP:0001355)1.72859855
114Ventricular fibrillation (HP:0001663)1.70754190
115Abnormal hair whorl (HP:0010721)1.69462566
116Akinesia (HP:0002304)1.69399306
117Resting tremor (HP:0002322)1.68372201
118Septo-optic dysplasia (HP:0100842)1.67604599
119Aplasia/Hypoplasia of the brainstem (HP:0007362)1.67251846
120Retinal dysplasia (HP:0007973)1.67094668
121Intellectual disability, severe (HP:0010864)1.67019735

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.24697225
2CASK4.57375055
3NTRK34.33033163
4MAP3K93.31481628
5DAPK23.19335317
6MAP3K42.90596471
7MAP2K72.70374635
8MARK12.34223960
9MAP3K122.32347014
10MINK12.21260920
11DAPK12.18027716
12CDK192.17645445
13RIPK42.13798609
14PLK22.08953963
15MAP2K41.85264434
16PAK61.84278933
17CCNB11.80888628
18NTRK21.77838732
19KSR21.77468720
20KSR11.69221168
21PRPF4B1.59035858
22CAMKK11.53298599
23TNIK1.45657972
24ARAF1.40438924
25CDK51.39542589
26CAMKK21.36787894
27GRK51.31930106
28AKT31.31907421
29MAPK131.30173038
30NTRK11.28762484
31MAP3K131.23299600
32PRKCG1.22664650
33SIK21.21013418
34PNCK1.19297971
35OXSR11.16024462
36DYRK21.15763599
37FES1.13611266
38PTK2B1.13548709
39PRKD31.11480591
40CAMK2A1.10218374
41CAMK2B1.03039133
42BMPR20.96020165
43STK380.91993565
44RAF10.89173546
45CAMK10.88362366
46CDK180.87409736
47SGK4940.85618528
48SGK2230.85618528
49ALK0.85056851
50MAP3K20.84318051
51CDK150.83467548
52SGK20.80493798
53CDK140.79147287
54TYRO30.74648794
55UHMK10.74124883
56BRAF0.73845667
57STK110.73697955
58WNK30.72714218
59NME10.72409152
60CDK11A0.72005052
61SGK10.68054815
62SIK30.67674170
63PKN10.67075050
64DAPK30.63478733
65DYRK1A0.62205200
66TAOK10.61262378
67FGR0.60232543
68CAMK1G0.59988359
69LATS20.59937595
70CSNK1G30.59832835
71PRKCH0.58165783
72MARK20.57381875
73SGK30.57170060
74PDK10.57081383
75CSNK1A1L0.56633583
76PHKG20.56581478
77PHKG10.56581478
78PDPK10.55429921
79GRK70.55080431
80PRKCE0.54772375
81RET0.54196898
82CAMK1D0.52639597
83TRIM280.52116887
84CSNK1G20.51853517
85MAP3K110.50218248
86PAK30.50072667
87RIPK10.49789415
88MAPK120.48888114
89CSNK1G10.48461016
90CAMK2D0.47898245
91BRSK10.45855691
92FER0.45718746
93CAMK2G0.45547341
94TSSK60.45189546
95MAP4K20.44183307
96MAPK70.43756650
97PINK10.43444219
98MAP3K10.43238730
99CAMK40.42176326
100CSNK1E0.40762956
101MAP2K10.40616712
102RPS6KA30.38511519
103PRKCZ0.38188037
104PRKG10.37942067
105TNK20.37042673
106MAP3K60.37000021
107FYN0.36674079
108LIMK10.36230521
109INSRR0.35580367
110MUSK0.34704651
111NEK60.34200035
112CSNK1D0.33882319
113MAP3K70.33123343
114ADRBK10.31837681
115CSNK1A10.31354306
116FGFR20.31256092
117MAP3K50.30695706
118CDK30.29715126
119WNK10.29354143
120BCR0.27843711
121MAPK100.27843385
122GSK3B0.27737718
123PRKACA0.27732120
124PRKCA0.27705370
125ROCK20.27690765
126PDK30.27364157

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.29434239
2Synaptic vesicle cycle_Homo sapiens_hsa047213.53064841
3Long-term potentiation_Homo sapiens_hsa047202.95756551
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.94402132
5Circadian entrainment_Homo sapiens_hsa047132.85388284
6Amphetamine addiction_Homo sapiens_hsa050312.72405264
7Glutamatergic synapse_Homo sapiens_hsa047242.67832219
8Olfactory transduction_Homo sapiens_hsa047402.66435638
9Morphine addiction_Homo sapiens_hsa050322.64280223
10GABAergic synapse_Homo sapiens_hsa047272.63127181
11Salivary secretion_Homo sapiens_hsa049702.28902634
12Dopaminergic synapse_Homo sapiens_hsa047282.20828640
13Collecting duct acid secretion_Homo sapiens_hsa049662.03496628
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.99911702
15Insulin secretion_Homo sapiens_hsa049111.98096363
16Taste transduction_Homo sapiens_hsa047421.94562410
17Long-term depression_Homo sapiens_hsa047301.87930701
18Gastric acid secretion_Homo sapiens_hsa049711.87168698
19Cholinergic synapse_Homo sapiens_hsa047251.83080281
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79586601
21Renin secretion_Homo sapiens_hsa049241.78836212
22Oxytocin signaling pathway_Homo sapiens_hsa049211.78082586
23Serotonergic synapse_Homo sapiens_hsa047261.75114254
24Calcium signaling pathway_Homo sapiens_hsa040201.72918001
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59534767
26Cocaine addiction_Homo sapiens_hsa050301.55092444
27GnRH signaling pathway_Homo sapiens_hsa049121.42797602
28Gap junction_Homo sapiens_hsa045401.31623997
29cAMP signaling pathway_Homo sapiens_hsa040241.31604834
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29785063
31Vibrio cholerae infection_Homo sapiens_hsa051101.24933927
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24156370
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22802892
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.17565193
35Axon guidance_Homo sapiens_hsa043601.15457091
36Estrogen signaling pathway_Homo sapiens_hsa049151.09740549
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09689519
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07543226
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06247978
40Glioma_Homo sapiens_hsa052141.06094641
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00937357
42Type II diabetes mellitus_Homo sapiens_hsa049300.99720722
43Melanogenesis_Homo sapiens_hsa049160.99510500
44Cardiac muscle contraction_Homo sapiens_hsa042600.98093024
45ErbB signaling pathway_Homo sapiens_hsa040120.97515054
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97240058
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.95097085
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94278734
49Vitamin B6 metabolism_Homo sapiens_hsa007500.90017260
50Phototransduction_Homo sapiens_hsa047440.85265622
51Oocyte meiosis_Homo sapiens_hsa041140.83464327
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83317824
53Pancreatic secretion_Homo sapiens_hsa049720.83268999
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79959176
55Dilated cardiomyopathy_Homo sapiens_hsa054140.74867816
56Fatty acid biosynthesis_Homo sapiens_hsa000610.72893150
57MAPK signaling pathway_Homo sapiens_hsa040100.72486385
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.70612462
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69768572
60Thyroid hormone synthesis_Homo sapiens_hsa049180.67617199
61Choline metabolism in cancer_Homo sapiens_hsa052310.64010481
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61306586
63Dorso-ventral axis formation_Homo sapiens_hsa043200.60771119
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59177587
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58555199
66Ras signaling pathway_Homo sapiens_hsa040140.56593911
67Alzheimers disease_Homo sapiens_hsa050100.56511493
68Circadian rhythm_Homo sapiens_hsa047100.55765705
69Glucagon signaling pathway_Homo sapiens_hsa049220.54636726
70Rap1 signaling pathway_Homo sapiens_hsa040150.54141109
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52833773
72VEGF signaling pathway_Homo sapiens_hsa043700.52281200
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.51034891
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49948161
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46368276
76Oxidative phosphorylation_Homo sapiens_hsa001900.46174981
77African trypanosomiasis_Homo sapiens_hsa051430.45652904
78Alcoholism_Homo sapiens_hsa050340.44465697
79Inositol phosphate metabolism_Homo sapiens_hsa005620.44320991
80Parkinsons disease_Homo sapiens_hsa050120.44319056
81Rheumatoid arthritis_Homo sapiens_hsa053230.43442897
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43431239
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40592967
84Hippo signaling pathway_Homo sapiens_hsa043900.40332073
85Wnt signaling pathway_Homo sapiens_hsa043100.39619837
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.39601834
87Tight junction_Homo sapiens_hsa045300.38235612
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37822553
89Type I diabetes mellitus_Homo sapiens_hsa049400.36987618
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36660346
91Prion diseases_Homo sapiens_hsa050200.36371127
92Arginine and proline metabolism_Homo sapiens_hsa003300.35821247
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34665650
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33629149
95mTOR signaling pathway_Homo sapiens_hsa041500.32951050
96Bile secretion_Homo sapiens_hsa049760.32839871
97Ovarian steroidogenesis_Homo sapiens_hsa049130.31256192
98Renal cell carcinoma_Homo sapiens_hsa052110.30464397
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29566975
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29497715
101Non-small cell lung cancer_Homo sapiens_hsa052230.29088379
102Endocytosis_Homo sapiens_hsa041440.28927538
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25806583
104Insulin signaling pathway_Homo sapiens_hsa049100.25766742
105Huntingtons disease_Homo sapiens_hsa050160.25026294
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24428567
107Chemokine signaling pathway_Homo sapiens_hsa040620.23755660
108Endometrial cancer_Homo sapiens_hsa052130.23369577
109Phagosome_Homo sapiens_hsa041450.20429170
110Histidine metabolism_Homo sapiens_hsa003400.19800484
111Butanoate metabolism_Homo sapiens_hsa006500.19520840
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.19485272
113AMPK signaling pathway_Homo sapiens_hsa041520.18383558
114beta-Alanine metabolism_Homo sapiens_hsa004100.17919126
115Hedgehog signaling pathway_Homo sapiens_hsa043400.15930762

Most similar genes based on co-expression Upload to Enrichr

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