BRINP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.83431138
2vocalization behavior (GO:0071625)5.74492736
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.65217281
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.54936021
5synaptic vesicle exocytosis (GO:0016079)5.41874577
6synaptic vesicle maturation (GO:0016188)5.39952924
7glutamate secretion (GO:0014047)5.33965403
8neuron cell-cell adhesion (GO:0007158)5.31019448
9locomotory exploration behavior (GO:0035641)5.25156154
10protein localization to synapse (GO:0035418)5.21291719
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.13437813
12regulation of glutamate receptor signaling pathway (GO:1900449)5.10448835
13synaptic vesicle docking involved in exocytosis (GO:0016081)5.02900551
14regulation of synaptic vesicle exocytosis (GO:2000300)5.02185775
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.74515661
16pyrimidine nucleobase catabolic process (GO:0006208)4.65827419
17exploration behavior (GO:0035640)4.43334037
18regulation of synaptic vesicle transport (GO:1902803)4.43060044
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.41483153
20neuronal action potential propagation (GO:0019227)4.38284222
21synaptic transmission, glutamatergic (GO:0035249)4.37539015
22glutamate receptor signaling pathway (GO:0007215)4.32626413
23amino acid import (GO:0043090)4.29188426
24neurotransmitter-gated ion channel clustering (GO:0072578)4.29047354
25neurotransmitter secretion (GO:0007269)4.27785942
26regulation of long-term neuronal synaptic plasticity (GO:0048169)4.25340587
27regulation of neuronal synaptic plasticity (GO:0048168)4.22398033
28regulation of synapse structural plasticity (GO:0051823)4.16402879
29layer formation in cerebral cortex (GO:0021819)4.12531645
30L-amino acid import (GO:0043092)4.11296387
31neuron-neuron synaptic transmission (GO:0007270)4.11071400
32dendritic spine morphogenesis (GO:0060997)4.04744406
33neuronal ion channel clustering (GO:0045161)4.03421113
34postsynaptic membrane organization (GO:0001941)4.00604508
35sodium ion export (GO:0071436)3.93371113
36nucleobase catabolic process (GO:0046113)3.93363856
37proline transport (GO:0015824)3.91209781
38establishment of mitochondrion localization (GO:0051654)3.90344589
39neuron recognition (GO:0008038)3.88568707
40gamma-aminobutyric acid transport (GO:0015812)3.83409667
41regulation of excitatory postsynaptic membrane potential (GO:0060079)3.81909493
42positive regulation of membrane potential (GO:0045838)3.77958466
43presynaptic membrane assembly (GO:0097105)3.77698050
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.77134206
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.76016048
46regulation of postsynaptic membrane potential (GO:0060078)3.70041464
47axonal fasciculation (GO:0007413)3.67751415
48positive regulation of synapse maturation (GO:0090129)3.65573619
49regulation of neurotransmitter secretion (GO:0046928)3.64738729
50negative regulation of synaptic transmission, GABAergic (GO:0032229)3.64362926
51acidic amino acid transport (GO:0015800)3.63606181
52long-term memory (GO:0007616)3.62601035
53central nervous system myelination (GO:0022010)3.52618582
54axon ensheathment in central nervous system (GO:0032291)3.52618582
55regulation of synaptic transmission, glutamatergic (GO:0051966)3.52596544
56regulation of dendritic spine morphogenesis (GO:0061001)3.52586037
57regulation of synaptic plasticity (GO:0048167)3.51208412
58regulation of voltage-gated calcium channel activity (GO:1901385)3.50130660
59positive regulation of neurotransmitter secretion (GO:0001956)3.49540423
60gamma-aminobutyric acid signaling pathway (GO:0007214)3.47377705
61positive regulation of synaptic transmission, GABAergic (GO:0032230)3.47286780
62neurotransmitter transport (GO:0006836)3.46983497
63response to auditory stimulus (GO:0010996)3.46849090
64auditory behavior (GO:0031223)3.45377237
65positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.44803663
66G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.44297080
67presynaptic membrane organization (GO:0097090)3.43456767
68long-term synaptic potentiation (GO:0060291)3.40739576
69synaptic vesicle endocytosis (GO:0048488)3.40638153
70cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.39842489
71positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.37091266
72transmission of nerve impulse (GO:0019226)3.34522941
73regulation of neurotransmitter transport (GO:0051588)3.34521225
74regulation of vesicle fusion (GO:0031338)3.34337701
75positive regulation of neurotransmitter transport (GO:0051590)3.34118196
76cerebellar Purkinje cell differentiation (GO:0021702)3.31341155
77regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.29574848
78G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.29174173
79cellular potassium ion homeostasis (GO:0030007)3.27725119
80dendrite morphogenesis (GO:0048813)3.24681821
81innervation (GO:0060384)3.22775743
82cell communication by electrical coupling (GO:0010644)3.21159626
83cell migration in hindbrain (GO:0021535)3.20149863
84synapse assembly (GO:0007416)3.20134119
85regulation of neurotransmitter levels (GO:0001505)3.18937471
86membrane depolarization (GO:0051899)3.17792267
87neuromuscular synaptic transmission (GO:0007274)3.16958705
88activation of protein kinase A activity (GO:0034199)3.14932019
89membrane hyperpolarization (GO:0060081)3.14854178
90negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.14641652
91regulation of dendritic spine development (GO:0060998)3.10650682
92learning (GO:0007612)3.10140240
93neuromuscular process controlling balance (GO:0050885)3.06945464
94membrane depolarization during action potential (GO:0086010)3.06720055
95L-glutamate transport (GO:0015813)3.05032490
96C4-dicarboxylate transport (GO:0015740)3.03321378
97glycosphingolipid biosynthetic process (GO:0006688)3.03092581
98potassium ion import (GO:0010107)3.02604232
99regulation of synaptic transmission (GO:0050804)3.02582868
100establishment of synaptic vesicle localization (GO:0097480)3.02479602
101synaptic vesicle transport (GO:0048489)3.02479602
102positive regulation of synaptic transmission (GO:0050806)3.01998563
103synaptic transmission (GO:0007268)3.01965847
104mechanosensory behavior (GO:0007638)3.01736810
105regulation of synapse maturation (GO:0090128)3.01645772
106adult walking behavior (GO:0007628)3.01505840
107potassium ion homeostasis (GO:0055075)3.01139199
108response to histamine (GO:0034776)3.00714822
109positive regulation of dendritic spine development (GO:0060999)3.00347017
110dendritic spine organization (GO:0097061)3.00063070
111positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.99378996
112central nervous system projection neuron axonogenesis (GO:0021952)2.98058222
113regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.98032100
114regulation of respiratory system process (GO:0044065)2.96814142
115positive regulation of synapse assembly (GO:0051965)2.90528714
116cerebellar granule cell differentiation (GO:0021707)2.90163809
117positive regulation of dendritic spine morphogenesis (GO:0061003)2.89889827
118negative regulation of dendrite development (GO:2000171)2.89413442
119synapse organization (GO:0050808)2.86559673
120regulation of synaptic transmission, GABAergic (GO:0032228)2.86213209
121social behavior (GO:0035176)2.84812122
122intraspecies interaction between organisms (GO:0051703)2.84812122
123startle response (GO:0001964)2.84369597

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.38497228
2GBX2_23144817_ChIP-Seq_PC3_Human3.88846182
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.21764359
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.19626937
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08645147
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.75838751
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.75838751
8REST_21632747_ChIP-Seq_MESCs_Mouse2.73408839
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.73101585
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.71953952
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.69429206
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.66702443
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53940414
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47913957
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.46355133
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.44916173
17DROSHA_22980978_ChIP-Seq_HELA_Human2.31028695
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.30736449
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.30242971
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.28632987
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.24464102
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20432119
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.16445511
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.07028629
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.01226772
26TAF15_26573619_Chip-Seq_HEK293_Human2.00908431
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.90264592
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88648446
29AR_21572438_ChIP-Seq_LNCaP_Human1.80799818
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76721172
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74626118
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72843168
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70808325
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.70737813
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66120198
36SMAD4_21799915_ChIP-Seq_A2780_Human1.65869999
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57886985
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57142015
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55527842
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.54450071
41P300_19829295_ChIP-Seq_ESCs_Human1.53397498
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.50084475
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43995580
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43430050
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42067477
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40230112
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.37083390
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36447486
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.34734239
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34199454
51ZNF274_21170338_ChIP-Seq_K562_Hela1.33889353
52RING1B_27294783_Chip-Seq_ESCs_Mouse1.32910617
53ZFP281_18757296_ChIP-ChIP_E14_Mouse1.31570587
54RNF2_27304074_Chip-Seq_NSC_Mouse1.30616206
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29476795
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.28969234
57AR_25329375_ChIP-Seq_VCAP_Human1.28816320
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23157222
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22815767
60RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20202072
61STAT3_23295773_ChIP-Seq_U87_Human1.20028312
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.19872044
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17959388
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16029045
65CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15204506
66GATA1_26923725_Chip-Seq_HPCs_Mouse1.14040470
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13724295
68IGF1R_20145208_ChIP-Seq_DFB_Human1.13060430
69P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12801427
70AR_19668381_ChIP-Seq_PC3_Human1.12535096
71RING1B_27294783_Chip-Seq_NPCs_Mouse1.12247522
72OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09060550
73TCF4_23295773_ChIP-Seq_U87_Human1.08628110
74FUS_26573619_Chip-Seq_HEK293_Human1.06408829
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05365425
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05365425
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.05354284
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03569515
79RUNX2_22187159_ChIP-Seq_PCA_Human1.03505666
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03387632
81TET1_21490601_ChIP-Seq_MESCs_Mouse1.02673651
82MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02432506
83* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02333628
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02316698
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.02140484
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02097587
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00991697
88ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99987438
89CTCF_27219007_Chip-Seq_Bcells_Human0.99229826
90HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98757787
91NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97490850
92DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97381822
93JUN_21703547_ChIP-Seq_K562_Human0.96358174
94AHR_22903824_ChIP-Seq_MCF-7_Human0.95907244
95SMAD3_21741376_ChIP-Seq_ESCs_Human0.95795766
96KDM2B_26808549_Chip-Seq_K562_Human0.95540992
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95368951
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94042888
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93982043
100RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93334805
101EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92984605
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92695568
103NANOG_18555785_Chip-Seq_ESCs_Mouse0.92535236
104VDR_22108803_ChIP-Seq_LS180_Human0.92150683
105SMAD4_21741376_ChIP-Seq_HESCs_Human0.90650573
106SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90014136
107ER_23166858_ChIP-Seq_MCF-7_Human0.89657683
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88422893
109LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87731016
110ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87107033
111TP53_18474530_ChIP-ChIP_U2OS_Human0.86761713
112SMAD3_21741376_ChIP-Seq_HESCs_Human0.86506709
113ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86146288
114TP53_16413492_ChIP-PET_HCT116_Human0.83123246
115TP53_20018659_ChIP-ChIP_R1E_Mouse0.82146583
116KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.82017282
117E2F1_18555785_Chip-Seq_ESCs_Mouse0.81761153
118WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.81645314
119SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.78983112
120SOX9_26525672_Chip-Seq_HEART_Mouse0.75234820
121EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.75171581

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.16809061
2MP0003880_abnormal_central_pattern4.68497355
3MP0003635_abnormal_synaptic_transmissio4.08723688
4MP0004270_analgesia3.86455124
5MP0009745_abnormal_behavioral_response3.43975667
6MP0002063_abnormal_learning/memory/cond3.33316045
7MP0001968_abnormal_touch/_nociception3.22656468
8MP0002064_seizures3.09901786
9MP0009046_muscle_twitch2.94700330
10MP0005423_abnormal_somatic_nervous2.93046668
11MP0002572_abnormal_emotion/affect_behav2.85289700
12MP0002734_abnormal_mechanical_nocicepti2.79600734
13MP0002736_abnormal_nociception_after2.70078600
14MP0001486_abnormal_startle_reflex2.57725183
15MP0002272_abnormal_nervous_system2.56278078
16MP0002822_catalepsy2.52137281
17MP0002735_abnormal_chemical_nociception2.51174105
18MP0001440_abnormal_grooming_behavior2.22142103
19MP0002733_abnormal_thermal_nociception2.18487407
20MP0000778_abnormal_nervous_system2.16226452
21MP0001501_abnormal_sleep_pattern2.11343305
22MP0004858_abnormal_nervous_system2.08518065
23MP0001970_abnormal_pain_threshold2.08198685
24MP0001984_abnormal_olfaction2.02802873
25MP0002067_abnormal_sensory_capabilities2.01364072
26MP0002184_abnormal_innervation1.98513637
27MP0006276_abnormal_autonomic_nervous1.93132664
28MP0002557_abnormal_social/conspecific_i1.90029242
29MP0009780_abnormal_chondrocyte_physiolo1.80654120
30MP0003879_abnormal_hair_cell1.75084298
31MP0004811_abnormal_neuron_physiology1.74870394
32MP0005646_abnormal_pituitary_gland1.74302046
33MP0005645_abnormal_hypothalamus_physiol1.74167434
34MP0008569_lethality_at_weaning1.73203137
35MP0005386_behavior/neurological_phenoty1.71018447
36MP0004924_abnormal_behavior1.71018447
37MP0001529_abnormal_vocalization1.57327341
38MP0000955_abnormal_spinal_cord1.56948848
39MP0003329_amyloid_beta_deposits1.52792959
40MP0003787_abnormal_imprinting1.50170129
41MP0002882_abnormal_neuron_morphology1.47084032
42MP0001905_abnormal_dopamine_level1.42079488
43MP0002066_abnormal_motor_capabilities/c1.39399867
44MP0002909_abnormal_adrenal_gland1.37970489
45MP0001188_hyperpigmentation1.36356319
46MP0004885_abnormal_endolymph1.33970462
47MP0001502_abnormal_circadian_rhythm1.32447945
48MP0003633_abnormal_nervous_system1.24990185
49MP0004142_abnormal_muscle_tone1.23101142
50MP0010386_abnormal_urinary_bladder1.22362962
51MP0002152_abnormal_brain_morphology1.16130072
52MP0003122_maternal_imprinting1.14359450
53MP0004742_abnormal_vestibular_system1.11839300
54MP0003631_nervous_system_phenotype1.05305975
55MP0005394_taste/olfaction_phenotype1.04203594
56MP0005499_abnormal_olfactory_system1.04203594
57MP0000631_abnormal_neuroendocrine_gland1.01396349
58MP0001963_abnormal_hearing_physiology0.98237994
59MP0003123_paternal_imprinting0.94524751
60MP0008872_abnormal_physiological_respon0.94053408
61MP0002069_abnormal_eating/drinking_beha0.93525538
62MP0002638_abnormal_pupillary_reflex0.93392430
63MP0002876_abnormal_thyroid_physiology0.91077113
64MP0001485_abnormal_pinna_reflex0.90928479
65MP0002229_neurodegeneration0.90439245
66MP0003121_genomic_imprinting0.89726711
67MP0005551_abnormal_eye_electrophysiolog0.88991095
68MP0002752_abnormal_somatic_nervous0.86541919
69MP0000569_abnormal_digit_pigmentation0.84781786
70MP0003938_abnormal_ear_development0.82997756
71MP0006292_abnormal_olfactory_placode0.82382559
72MP0008874_decreased_physiological_sensi0.82263798
73MP0003634_abnormal_glial_cell0.81759039
74MP0001177_atelectasis0.79273452
75MP0000751_myopathy0.78645725
76MP0005623_abnormal_meninges_morphology0.78543963
77MP0004130_abnormal_muscle_cell0.77388360
78MP0004147_increased_porphyrin_level0.77189275
79MP0004085_abnormal_heartbeat0.76082276
80MP0005409_darkened_coat_color0.75642659
81MP0008877_abnormal_DNA_methylation0.74881346
82MP0005535_abnormal_body_temperature0.71601343
83MP0001664_abnormal_digestion0.71178324
84MP0004145_abnormal_muscle_electrophysio0.68468710
85MP0005167_abnormal_blood-brain_barrier0.68304586
86MP0000026_abnormal_inner_ear0.67968317
87MP0003632_abnormal_nervous_system0.67309746
88MP0003861_abnormal_nervous_system0.66552575
89MP0000920_abnormal_myelination0.66140395
90MP0000566_synostosis0.65726259
91MP0002751_abnormal_autonomic_nervous0.63060462
92MP0003137_abnormal_impulse_conducting0.62761573
93MP0005171_absent_coat_pigmentation0.62226564
94MP0002102_abnormal_ear_morphology0.60980824
95MP0001299_abnormal_eye_distance/0.59276369
96MP0002249_abnormal_larynx_morphology0.59104845
97MP0002090_abnormal_vision0.58304221
98MP0003075_altered_response_to0.58090393
99MP0001943_abnormal_respiration0.57448132
100MP0005253_abnormal_eye_physiology0.57337129
101MP0003690_abnormal_glial_cell0.56625935
102MP0002837_dystrophic_cardiac_calcinosis0.56444208
103MP0004215_abnormal_myocardial_fiber0.56330302
104MP0000639_abnormal_adrenal_gland0.55939768
105MP0000013_abnormal_adipose_tissue0.55242211
106MP0008961_abnormal_basal_metabolism0.54868402
107MP0003183_abnormal_peptide_metabolism0.54597069
108MP0001986_abnormal_taste_sensitivity0.54484774
109MP0010769_abnormal_survival0.53825694
110MP0002082_postnatal_lethality0.53817206
111MP0008789_abnormal_olfactory_epithelium0.53607156
112MP0004484_altered_response_of0.53418507
113MP0002653_abnormal_ependyma_morphology0.53400857
114MP0000604_amyloidosis0.53323604
115MP0010770_preweaning_lethality0.53072435
116MP0005187_abnormal_penis_morphology0.52359868
117MP0010768_mortality/aging0.51907397

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.13688103
2Myokymia (HP:0002411)6.78884863
3Focal seizures (HP:0007359)6.02265035
4Visual hallucinations (HP:0002367)5.26987818
5Epileptic encephalopathy (HP:0200134)5.22254030
6Febrile seizures (HP:0002373)4.79608591
7Atonic seizures (HP:0010819)4.72850941
8Absence seizures (HP:0002121)4.41767251
9Progressive cerebellar ataxia (HP:0002073)4.33583264
10Dialeptic seizures (HP:0011146)4.04164401
11Generalized tonic-clonic seizures (HP:0002069)3.97725706
12Hyperventilation (HP:0002883)3.72111727
13Broad-based gait (HP:0002136)3.61641443
14Action tremor (HP:0002345)3.45100190
15Ankle clonus (HP:0011448)3.36496291
16Split foot (HP:0001839)3.36001554
17Peripheral hypomyelination (HP:0007182)3.35408599
18Poor eye contact (HP:0000817)3.32910027
19Gaze-evoked nystagmus (HP:0000640)3.31099688
20Supranuclear gaze palsy (HP:0000605)3.22350694
21Amblyopia (HP:0000646)3.21835640
22Impaired vibration sensation in the lower limbs (HP:0002166)3.19949816
23Urinary bladder sphincter dysfunction (HP:0002839)3.05535209
24Abnormal eating behavior (HP:0100738)2.97561032
25Truncal ataxia (HP:0002078)2.92253589
26Depression (HP:0000716)2.91461763
27Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.89866114
28Degeneration of the lateral corticospinal tracts (HP:0002314)2.89866114
29Mutism (HP:0002300)2.87237556
30Abnormal social behavior (HP:0012433)2.85718191
31Impaired social interactions (HP:0000735)2.85718191
32Drooling (HP:0002307)2.84637190
33Excessive salivation (HP:0003781)2.84637190
34Limb dystonia (HP:0002451)2.79874212
35Dysdiadochokinesis (HP:0002075)2.79275009
36Anxiety (HP:0000739)2.78888305
37Dysmetria (HP:0001310)2.71744169
38Fetal akinesia sequence (HP:0001989)2.65695766
39Progressive inability to walk (HP:0002505)2.63050209
40Hemiparesis (HP:0001269)2.62987085
41Cerebral hypomyelination (HP:0006808)2.59724752
42Inability to walk (HP:0002540)2.59106740
43Genetic anticipation (HP:0003743)2.58859784
44Epileptiform EEG discharges (HP:0011182)2.58765305
45Polyphagia (HP:0002591)2.57283638
46Urinary urgency (HP:0000012)2.55315666
47Abnormality of binocular vision (HP:0011514)2.52907334
48Diplopia (HP:0000651)2.52907334
49Absent speech (HP:0001344)2.48011912
50Postural instability (HP:0002172)2.46458025
51Spastic tetraplegia (HP:0002510)2.45842638
52Spastic gait (HP:0002064)2.45664500
53Impaired smooth pursuit (HP:0007772)2.45504385
54Clonus (HP:0002169)2.43928074
55EEG with generalized epileptiform discharges (HP:0011198)2.43548365
56Abnormality of the corticospinal tract (HP:0002492)2.38533575
57Morphological abnormality of the pyramidal tract (HP:0002062)2.36543640
58Stereotypic behavior (HP:0000733)2.36510596
59Torticollis (HP:0000473)2.36033041
60Pheochromocytoma (HP:0002666)2.35522936
61Termporal pattern (HP:0011008)2.29763553
62Insidious onset (HP:0003587)2.29763553
63Hypsarrhythmia (HP:0002521)2.28931321
64Neuronal loss in central nervous system (HP:0002529)2.27205351
65Focal dystonia (HP:0004373)2.26635841
66Hypoplasia of the corpus callosum (HP:0002079)2.26525301
67Papilledema (HP:0001085)2.26110399
68Impaired vibratory sensation (HP:0002495)2.24252134
69Abnormality of the lower motor neuron (HP:0002366)2.22679096
70Megalencephaly (HP:0001355)2.22438679
71Bradykinesia (HP:0002067)2.20702897
72Lower limb muscle weakness (HP:0007340)2.19926959
73Scanning speech (HP:0002168)2.19533375
74Apathy (HP:0000741)2.17368690
75Cortical dysplasia (HP:0002539)2.15803052
76Neurofibrillary tangles (HP:0002185)2.14447917
77Cerebral inclusion bodies (HP:0100314)2.14357901
78Gait imbalance (HP:0002141)2.13718801
79Abnormality of ocular smooth pursuit (HP:0000617)2.13063196
80Generalized myoclonic seizures (HP:0002123)2.10730200
81Diminished motivation (HP:0000745)2.09686742
82Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.08810457
83Neuroendocrine neoplasm (HP:0100634)2.07708045
84Tetraplegia (HP:0002445)2.07361447
85Protruding tongue (HP:0010808)2.06397353
86Blue irides (HP:0000635)2.05434853
87Specific learning disability (HP:0001328)2.03580888
88Retinal dysplasia (HP:0007973)2.02476080
89Hemiplegia (HP:0002301)2.02145572
90Agitation (HP:0000713)2.01138230
91Abnormality of salivation (HP:0100755)2.00246360
92Akinesia (HP:0002304)1.99047224
93Incomplete penetrance (HP:0003829)1.98418990
94Insomnia (HP:0100785)1.95961759
95Craniofacial dystonia (HP:0012179)1.95157847
96Intention tremor (HP:0002080)1.95071078
97Status epilepticus (HP:0002133)1.94305285
98CNS hypomyelination (HP:0003429)1.93945497
99Intellectual disability, severe (HP:0010864)1.91774239
100Paraplegia (HP:0010550)1.88454292
101Sleep apnea (HP:0010535)1.86770298
102Aplasia/Hypoplasia of the brainstem (HP:0007362)1.85928480
103Hypoplasia of the brainstem (HP:0002365)1.85928480
104Obstructive sleep apnea (HP:0002870)1.83595542
105Hyperthyroidism (HP:0000836)1.83572280
106Dynein arm defect of respiratory motile cilia (HP:0012255)1.83149848
107Absent/shortened dynein arms (HP:0200106)1.83149848
108Amyotrophic lateral sclerosis (HP:0007354)1.82745920
109Failure to thrive in infancy (HP:0001531)1.82641255
110Choreoathetosis (HP:0001266)1.81354468
111Muscular hypotonia of the trunk (HP:0008936)1.79777577
112Abnormal hair whorl (HP:0010721)1.79618175
113Spastic tetraparesis (HP:0001285)1.78243474
114Gait ataxia (HP:0002066)1.76193778
115Delusions (HP:0000746)1.75967152
116Dysmetric saccades (HP:0000641)1.75741083
117Psychosis (HP:0000709)1.75311073
118Lower limb amyotrophy (HP:0007210)1.74389631
119Autism (HP:0000717)1.73583373
120Esotropia (HP:0000565)1.73368277
121Lissencephaly (HP:0001339)1.69429364
122Annular pancreas (HP:0001734)1.68824109

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.20298191
2NTRK34.15342048
3MARK13.77299016
4MAP3K93.48739521
5CASK3.17195173
6MAP3K42.86545457
7DAPK22.77964524
8MAP2K72.75871637
9MINK12.57529531
10MAP3K122.46298028
11NTRK22.36288063
12PAK62.06956020
13TNIK1.82506869
14PRPF4B1.81683849
15MAPK131.81345949
16MAP2K41.77567116
17DAPK11.74011231
18NTRK11.71511390
19RIPK41.67263861
20PLK21.64604732
21SIK21.63767140
22KSR11.63147810
23KSR21.62135344
24GRK51.58932492
25CDK51.54099461
26CDK191.52733490
27CAMKK11.46183894
28PRKD31.35762020
29ARAF1.24448232
30PHKG21.23494333
31PHKG11.23494333
32PRKCG1.23346066
33PNCK1.17149513
34SIK31.15956723
35UHMK11.12725466
36CSNK1A1L1.09821940
37TYRO31.00518803
38CAMK2A1.00411615
39FES0.98746996
40CDK180.94941387
41TRIM280.94493507
42LIMK10.94333112
43STK380.93682188
44SGK2230.92628500
45SGK4940.92628500
46EPHA30.90304419
47CAMKK20.90044172
48CDK150.89953901
49CDK140.88263373
50MAP3K20.87820203
51CSNK1G10.84821126
52LATS20.83533335
53CAMK2B0.83002212
54DYRK1A0.82736218
55BMPR20.82664636
56CAMK10.82096858
57OXSR10.81215973
58CSNK1G20.80459612
59CDK11A0.79897420
60CCNB10.78338004
61SGK20.78279001
62STK110.73706019
63TAOK10.70102154
64PAK30.69598934
65RET0.67419214
66MARK20.66283787
67TESK10.65622990
68PTK2B0.63959087
69RAF10.63803260
70SGK10.63453231
71MAP3K130.61352701
72MAP3K110.60433567
73PRKCE0.60264509
74IRAK20.56948534
75FGR0.54763842
76WNK30.54412130
77LMTK20.53957038
78PINK10.53848251
79BCR0.52887305
80PRKCH0.52845893
81NME10.51508574
82SGK30.51012488
83AKT30.50706408
84MAPK100.50145130
85RIPK10.48499345
86PRKCZ0.48119924
87ALK0.44403453
88NEK60.44399904
89GRK70.44233681
90TNK20.44042255
91DYRK20.44025366
92DYRK1B0.42564985
93FGFR20.41102073
94FYN0.41033368
95CAMK2D0.40907750
96CSNK1D0.40433694
97CAMK2G0.39789778
98FER0.39780222
99MAP3K10.39623854
100MAP3K60.39327809
101PDK10.38623273
102MAPK120.38539188
103RPS6KA30.38368912
104MAP2K10.38297376
105CAMK40.38247325
106CDC42BPA0.38171547
107RPS6KA20.37809431
108PDPK10.37708258
109BRAF0.37312817
110CSNK1A10.37230899
111DAPK30.37114369
112PRKACA0.36936562
113ERBB20.36314401
114ERBB30.36266657
115PKN10.35851907
116CSNK1G30.35787465
117ADRBK20.35692744
118ROCK20.34848307
119PRKCA0.31551674
120BRSK10.29022558
121PRKG10.27064983
122PRKD10.25298334

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.92443939
2Synaptic vesicle cycle_Homo sapiens_hsa047213.43797515
3Olfactory transduction_Homo sapiens_hsa047403.03526638
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.75832996
5Circadian entrainment_Homo sapiens_hsa047132.74519652
6GABAergic synapse_Homo sapiens_hsa047272.67018779
7Glutamatergic synapse_Homo sapiens_hsa047242.66377586
8Morphine addiction_Homo sapiens_hsa050322.59390747
9Long-term potentiation_Homo sapiens_hsa047202.51633494
10Amphetamine addiction_Homo sapiens_hsa050312.43051018
11Dopaminergic synapse_Homo sapiens_hsa047282.19472183
12Salivary secretion_Homo sapiens_hsa049702.16713173
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.04819719
14Insulin secretion_Homo sapiens_hsa049112.02872583
15Taste transduction_Homo sapiens_hsa047421.94679366
16Cholinergic synapse_Homo sapiens_hsa047251.94592556
17Serotonergic synapse_Homo sapiens_hsa047261.82245362
18Gastric acid secretion_Homo sapiens_hsa049711.81271603
19Collecting duct acid secretion_Homo sapiens_hsa049661.77162513
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.72990695
21Long-term depression_Homo sapiens_hsa047301.70803359
22Renin secretion_Homo sapiens_hsa049241.70727216
23Cocaine addiction_Homo sapiens_hsa050301.67362684
24Oxytocin signaling pathway_Homo sapiens_hsa049211.64212193
25Calcium signaling pathway_Homo sapiens_hsa040201.63026103
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59096495
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.55240387
28GnRH signaling pathway_Homo sapiens_hsa049121.41435150
29Axon guidance_Homo sapiens_hsa043601.37143362
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34259088
31Gap junction_Homo sapiens_hsa045401.33986100
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28733330
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.27076325
34cAMP signaling pathway_Homo sapiens_hsa040241.26059948
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20222081
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.16280897
37Vibrio cholerae infection_Homo sapiens_hsa051101.12066289
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09288769
39Estrogen signaling pathway_Homo sapiens_hsa049151.08745319
40Glioma_Homo sapiens_hsa052141.07226412
41Phototransduction_Homo sapiens_hsa047441.06510585
42ErbB signaling pathway_Homo sapiens_hsa040121.05974746
43Type II diabetes mellitus_Homo sapiens_hsa049301.04600003
44Melanogenesis_Homo sapiens_hsa049161.03463427
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00935854
46Cardiac muscle contraction_Homo sapiens_hsa042600.98979683
47Vitamin B6 metabolism_Homo sapiens_hsa007500.95572908
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91827291
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.88563986
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86452618
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.79548311
52Pancreatic secretion_Homo sapiens_hsa049720.79405582
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78049517
54Oocyte meiosis_Homo sapiens_hsa041140.76916130
55MAPK signaling pathway_Homo sapiens_hsa040100.71120472
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70801381
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70488455
58Choline metabolism in cancer_Homo sapiens_hsa052310.70148457
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68182814
60Dorso-ventral axis formation_Homo sapiens_hsa043200.68140665
61Butanoate metabolism_Homo sapiens_hsa006500.66544977
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66059362
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65568691
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64982763
65Thyroid hormone synthesis_Homo sapiens_hsa049180.64512260
66Ras signaling pathway_Homo sapiens_hsa040140.64417641
67Dilated cardiomyopathy_Homo sapiens_hsa054140.63942746
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63094721
69beta-Alanine metabolism_Homo sapiens_hsa004100.61086224
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60178679
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.58837038
72VEGF signaling pathway_Homo sapiens_hsa043700.57147678
73Alzheimers disease_Homo sapiens_hsa050100.56968994
74Regulation of autophagy_Homo sapiens_hsa041400.56176675
75Rap1 signaling pathway_Homo sapiens_hsa040150.54939728
76Alcoholism_Homo sapiens_hsa050340.54423470
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.52840832
78Type I diabetes mellitus_Homo sapiens_hsa049400.51210258
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50590957
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49263000
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49101579
82Wnt signaling pathway_Homo sapiens_hsa043100.48641169
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47815315
84Endometrial cancer_Homo sapiens_hsa052130.46692322
85Glucagon signaling pathway_Homo sapiens_hsa049220.46658358
86Oxidative phosphorylation_Homo sapiens_hsa001900.45890263
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45569633
88Circadian rhythm_Homo sapiens_hsa047100.44103375
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41840472
90Inositol phosphate metabolism_Homo sapiens_hsa005620.41606736
91AMPK signaling pathway_Homo sapiens_hsa041520.41258131
92Ovarian steroidogenesis_Homo sapiens_hsa049130.40631452
93Hippo signaling pathway_Homo sapiens_hsa043900.39713834
94Endocytosis_Homo sapiens_hsa041440.39573626
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39104359
96Arginine and proline metabolism_Homo sapiens_hsa003300.38254855
97African trypanosomiasis_Homo sapiens_hsa051430.37474536
98Histidine metabolism_Homo sapiens_hsa003400.37148948
99Prion diseases_Homo sapiens_hsa050200.35393701
100Insulin signaling pathway_Homo sapiens_hsa049100.33179244
101mTOR signaling pathway_Homo sapiens_hsa041500.33142934
102Non-small cell lung cancer_Homo sapiens_hsa052230.32855582
103Rheumatoid arthritis_Homo sapiens_hsa053230.32733387
104Chemokine signaling pathway_Homo sapiens_hsa040620.32694063
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30685325
106Colorectal cancer_Homo sapiens_hsa052100.30555802
107Parkinsons disease_Homo sapiens_hsa050120.30539073
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29654434
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29295878
110Renal cell carcinoma_Homo sapiens_hsa052110.29266574
111Bile secretion_Homo sapiens_hsa049760.28887883
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28118447
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28106428
114Tight junction_Homo sapiens_hsa045300.27539018
115Arginine biosynthesis_Homo sapiens_hsa002200.24126376
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.22682771

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