BRIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1telomere maintenance via semi-conservative replication (GO:0032201)5.21137413
2kinetochore organization (GO:0051383)5.14827748
3CENP-A containing nucleosome assembly (GO:0034080)5.12502716
4DNA strand elongation involved in DNA replication (GO:0006271)5.10199563
5telomere maintenance via recombination (GO:0000722)5.04426706
6chromatin remodeling at centromere (GO:0031055)4.99564255
7DNA replication initiation (GO:0006270)4.97208190
8DNA strand elongation (GO:0022616)4.90703965
9mitotic recombination (GO:0006312)4.88903148
10DNA replication checkpoint (GO:0000076)4.84989908
11regulation of centrosome duplication (GO:0010824)4.75641084
12meiotic chromosome segregation (GO:0045132)4.73519325
13protein localization to kinetochore (GO:0034501)4.61765804
14kinetochore assembly (GO:0051382)4.52859459
15DNA unwinding involved in DNA replication (GO:0006268)4.44319913
16nucleotide-excision repair, DNA gap filling (GO:0006297)4.40934059
17DNA replication-independent nucleosome organization (GO:0034724)4.40388664
18DNA replication-independent nucleosome assembly (GO:0006336)4.40388664
19mitotic chromosome condensation (GO:0007076)4.23574809
20attachment of spindle microtubules to kinetochore (GO:0008608)4.23311164
21DNA synthesis involved in DNA repair (GO:0000731)4.22781066
22mitotic metaphase plate congression (GO:0007080)4.20847250
23telomere maintenance via telomere lengthening (GO:0010833)4.15641887
24histone exchange (GO:0043486)4.06357232
25protein localization to chromosome, centromeric region (GO:0071459)4.02181918
26regulation of nuclear cell cycle DNA replication (GO:0033262)3.96170165
27nuclear pore organization (GO:0006999)3.93453569
28nuclear pore complex assembly (GO:0051292)3.91712313
29regulation of double-strand break repair via homologous recombination (GO:0010569)3.91238576
30metaphase plate congression (GO:0051310)3.90983347
31establishment of chromosome localization (GO:0051303)3.82114757
32regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.79603270
33mismatch repair (GO:0006298)3.77632352
34mitotic sister chromatid segregation (GO:0000070)3.75733259
35DNA topological change (GO:0006265)3.72978257
36protein K6-linked ubiquitination (GO:0085020)3.67998937
37negative regulation of DNA-dependent DNA replication (GO:2000104)3.56963113
38sister chromatid segregation (GO:0000819)3.56812562
39maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.56566283
40telomere maintenance (GO:0000723)3.49634365
41viral mRNA export from host cell nucleus (GO:0046784)3.48726347
42mitotic nuclear envelope disassembly (GO:0007077)3.48193227
43* DNA duplex unwinding (GO:0032508)3.47183133
44pore complex assembly (GO:0046931)3.46522822
45telomere organization (GO:0032200)3.44980818
46double-strand break repair via nonhomologous end joining (GO:0006303)3.44843350
47non-recombinational repair (GO:0000726)3.44843350
48chromosome condensation (GO:0030261)3.44010483
49DNA replication-dependent nucleosome assembly (GO:0006335)3.43663776
50DNA replication-dependent nucleosome organization (GO:0034723)3.43663776
51regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.41205186
52regulation of mitotic spindle checkpoint (GO:1903504)3.41205186
53sister chromatid cohesion (GO:0007062)3.38813561
54mitotic sister chromatid cohesion (GO:0007064)3.35790872
55DNA ligation (GO:0006266)3.35501589
56chromosome segregation (GO:0007059)3.34307892
57regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.33602268
58double-strand break repair via homologous recombination (GO:0000724)3.33371401
59recombinational repair (GO:0000725)3.33281966
60postreplication repair (GO:0006301)3.32022668
61regulation of spindle organization (GO:0090224)3.31961015
62centriole replication (GO:0007099)3.30675153
63spindle checkpoint (GO:0031577)3.29017875
64deoxyribonucleotide biosynthetic process (GO:0009263)3.28155787
65regulation of centriole replication (GO:0046599)3.27159391
66replication fork processing (GO:0031297)3.24495838
67DNA strand renaturation (GO:0000733)3.24369030
68positive regulation of mitotic sister chromatid separation (GO:1901970)3.23564748
69positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.23564748
70positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.23564748
71microtubule depolymerization (GO:0007019)3.21741562
72regulation of centrosome cycle (GO:0046605)3.21570281
73* DNA conformation change (GO:0071103)3.21226844
74chromatin assembly or disassembly (GO:0006333)3.21004132
75folic acid-containing compound biosynthetic process (GO:0009396)3.19682988
76regulation of mitotic metaphase/anaphase transition (GO:0030071)3.17740855
77translesion synthesis (GO:0019985)3.17225018
78positive regulation of chromosome segregation (GO:0051984)3.16415325
79regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.13811714
80membrane disassembly (GO:0030397)3.13010087
81nuclear envelope disassembly (GO:0051081)3.13010087
82DNA replication (GO:0006260)3.11772024
83DNA-dependent DNA replication (GO:0006261)3.11321467
84somatic hypermutation of immunoglobulin genes (GO:0016446)3.09602284
85somatic diversification of immune receptors via somatic mutation (GO:0002566)3.09602284
86somatic recombination of immunoglobulin gene segments (GO:0016447)3.09299092
87DNA packaging (GO:0006323)3.09178158
88intra-S DNA damage checkpoint (GO:0031573)3.09002357
89regulation of chromosome segregation (GO:0051983)3.08351796
90spindle assembly checkpoint (GO:0071173)3.08296093
91DNA double-strand break processing (GO:0000729)3.07215308
92regulation of DNA endoreduplication (GO:0032875)3.07205384
93negative regulation of DNA repair (GO:0045738)3.06450508
94positive regulation of DNA-dependent DNA replication (GO:2000105)3.03679324
95ATP-dependent chromatin remodeling (GO:0043044)3.03552110
96negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.03528802
97negative regulation of sister chromatid segregation (GO:0033046)3.03528802
98negative regulation of mitotic sister chromatid separation (GO:2000816)3.03528802
99negative regulation of mitotic sister chromatid segregation (GO:0033048)3.03528802
100regulation of sister chromatid segregation (GO:0033045)3.02648896
101regulation of mitotic sister chromatid separation (GO:0010965)3.02648896
102regulation of mitotic sister chromatid segregation (GO:0033047)3.02648896
103negative regulation of chromosome segregation (GO:0051985)3.02465029
104heterochromatin organization (GO:0070828)3.02429916
105protein localization to chromosome (GO:0034502)3.02429280
106regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.01768839
107negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.98862033
108deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.96120339
109mitotic spindle assembly checkpoint (GO:0007094)2.94059270
110transcription-coupled nucleotide-excision repair (GO:0006283)2.91032446
111mitotic spindle checkpoint (GO:0071174)2.90935003
112mitotic G2/M transition checkpoint (GO:0044818)2.90839108
113* double-strand break repair (GO:0006302)2.90203161
114regulation of double-strand break repair (GO:2000779)2.88896095
115mitotic cell cycle (GO:0000278)2.88885041
116somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.85835559
117somatic cell DNA recombination (GO:0016444)2.85835559
118DNA catabolic process, exonucleolytic (GO:0000738)2.85440879
119somatic diversification of immunoglobulins (GO:0016445)2.85051275
120DNA biosynthetic process (GO:0071897)2.84781586
121* DNA geometric change (GO:0032392)2.84565611
122resolution of meiotic recombination intermediates (GO:0000712)2.84405333
123regulation of sister chromatid cohesion (GO:0007063)2.82366131

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human5.08648548
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.96674770
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.77501388
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.28945447
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.99061217
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.82549516
7E2F1_21310950_ChIP-Seq_MCF-7_Human2.52479078
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.45330633
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.37190076
10AR_21909140_ChIP-Seq_LNCAP_Human2.36239245
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.20673412
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.19529185
13KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.15576577
14* ESR1_15608294_ChIP-ChIP_MCF-7_Human2.11654342
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.09376454
16MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.09073130
17VDR_23849224_ChIP-Seq_CD4+_Human2.03195934
18E2F7_22180533_ChIP-Seq_HELA_Human12.5638301
19* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.94120819
20TP63_19390658_ChIP-ChIP_HaCaT_Human1.93142320
21CREB1_15753290_ChIP-ChIP_HEK293T_Human1.91967355
22MYC_19079543_ChIP-ChIP_MESCs_Mouse1.90807408
23* ELK1_19687146_ChIP-ChIP_HELA_Human1.90411321
24* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.88746204
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.87915582
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.86033707
27FOXP3_21729870_ChIP-Seq_TREG_Human1.84691127
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.83715892
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.83257843
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.82792671
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.76310536
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73641771
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72123730
34HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71099767
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70360689
36* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70207169
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.69543280
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68567764
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66887407
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.59224360
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59014038
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.53277771
43CIITA_25753668_ChIP-Seq_RAJI_Human1.50421742
44XRN2_22483619_ChIP-Seq_HELA_Human1.49359081
45ER_23166858_ChIP-Seq_MCF-7_Human1.47721188
46TTF2_22483619_ChIP-Seq_HELA_Human1.44194391
47DCP1A_22483619_ChIP-Seq_HELA_Human1.43635553
48* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43140130
49IRF8_21731497_ChIP-ChIP_J774_Mouse1.41035382
50SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39656605
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.38035722
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35150835
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34130545
54* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34119456
55* SRF_21415370_ChIP-Seq_HL-1_Mouse1.32724487
56THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27473052
57IRF8_22096565_ChIP-ChIP_GC-B_Human1.27320920
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.25588906
59GABP_19822575_ChIP-Seq_HepG2_Human1.23702762
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23364315
61FUS_26573619_Chip-Seq_HEK293_Human1.23352547
62* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.21580026
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20171832
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.19589035
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19561219
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18972315
67MYC_18940864_ChIP-ChIP_HL60_Human1.18292139
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.14310184
69ZNF274_21170338_ChIP-Seq_K562_Hela1.10804994
70SPI1_23547873_ChIP-Seq_NB4_Human1.08826019
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08062176
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07307279
73KDM5A_27292631_Chip-Seq_BREAST_Human1.06762437
74* NOTCH1_21737748_ChIP-Seq_TLL_Human1.06290816
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05985243
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03708019
77* SOX2_16153702_ChIP-ChIP_HESCs_Human1.03412398
78TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02687339
79NANOG_16153702_ChIP-ChIP_HESCs_Human1.01368858
80FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00320456
81RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99887875
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99632935
83BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98649165
84BP1_19119308_ChIP-ChIP_Hs578T_Human0.96931717
85ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95280821
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95075995
87FLI1_27457419_Chip-Seq_LIVER_Mouse0.95002317
88SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94092513
89* EWS_26573619_Chip-Seq_HEK293_Human0.89010401
90SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88822547
91PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88683945
92FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.87113148
93* TDRD3_21172665_ChIP-Seq_MCF-7_Human0.85053972
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83525466
95ZFX_18555785_ChIP-Seq_MESCs_Mouse0.83513412
96FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.82784056
97MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.82010166
98PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.80218484
99STAT4_19710469_ChIP-ChIP_TH1__Mouse0.80128885
100PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.80086372
101CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.80033820
102CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.78494312
103* IRF1_19129219_ChIP-ChIP_H3396_Human0.77595652
104HIF1A_21447827_ChIP-Seq_MCF-7_Human0.76929212
105SOX17_20123909_ChIP-Seq_XEN_Mouse0.76534048
106POU3F2_20337985_ChIP-ChIP_501MEL_Human0.75106790
107TFEB_21752829_ChIP-Seq_HELA_Human0.74932120
108ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.74659128
109CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.74354675
110GATA3_24758297_ChIP-Seq_MCF-7_Human0.74052273
111E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.72844618
112NFE2_27457419_Chip-Seq_LIVER_Mouse0.72294221
113STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.71516156
114FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.71020990
115POU5F1_16153702_ChIP-ChIP_HESCs_Human0.69103183
116CHD1_26751641_Chip-Seq_LNCaP_Human0.68470129
117MYB_26560356_Chip-Seq_TH1_Human0.67912790
118ZNF217_24962896_ChIP-Seq_MCF-7_Human0.67566493
119MYC_22102868_ChIP-Seq_BL_Human0.67142078
120KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.66435884
121KAP1_22055183_ChIP-Seq_ESCs_Mouse0.66264342
122AHR_22903824_ChIP-Seq_MCF-7_Human0.65870351
123IGF1R_20145208_ChIP-Seq_DFB_Human0.65165345
124PCGF2_27294783_Chip-Seq_NPCs_Mouse0.64614837
125MYB_21317192_ChIP-Seq_ERMYB_Mouse0.64544921
126CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.63547750
127KLF4_18555785_ChIP-Seq_MESCs_Mouse0.63512573
128HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.63223412
129RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.61849831
130HOXB7_26014856_ChIP-Seq_BT474_Human0.60315503

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.22501622
2MP0008057_abnormal_DNA_replication4.65734431
3MP0003693_abnormal_embryo_hatching4.63817525
4MP0003111_abnormal_nucleus_morphology4.13348981
5MP0008058_abnormal_DNA_repair3.84289996
6MP0003077_abnormal_cell_cycle3.68820773
7MP0004957_abnormal_blastocyst_morpholog2.92686019
8MP0002396_abnormal_hematopoietic_system2.84116288
9MP0008877_abnormal_DNA_methylation2.76119945
10MP0008007_abnormal_cellular_replicative2.70234980
11MP0000569_abnormal_digit_pigmentation2.57216618
12MP0008932_abnormal_embryonic_tissue2.26185737
13MP0003786_premature_aging2.01417832
14MP0010307_abnormal_tumor_latency1.87916206
15MP0000015_abnormal_ear_pigmentation1.82201687
16MP0003718_maternal_effect1.79048430
17MP0004808_abnormal_hematopoietic_stem1.77144196
18MP0000490_abnormal_crypts_of1.70600976
19MP0000350_abnormal_cell_proliferation1.68841711
20MP0000383_abnormal_hair_follicle1.68307910
21MP0000427_abnormal_hair_cycle1.65570777
22MP0006292_abnormal_olfactory_placode1.60929640
23MP0001835_abnormal_antigen_presentation1.58623181
24MP0005174_abnormal_tail_pigmentation1.55375428
25MP0003121_genomic_imprinting1.55326988
26MP0003787_abnormal_imprinting1.52724478
27MP0009697_abnormal_copulation1.52593842
28MP0005076_abnormal_cell_differentiation1.48522356
29MP0009672_abnormal_birth_weight1.47014948
30MP0002210_abnormal_sex_determination1.45180778
31MP0002160_abnormal_reproductive_system1.45093971
32MP0001188_hyperpigmentation1.44530144
33MP0001119_abnormal_female_reproductive1.42279574
34MP0003763_abnormal_thymus_physiology1.42270974
35MP0010678_abnormal_skin_adnexa1.38360316
36MP0002697_abnormal_eye_size1.34856163
37MP0002751_abnormal_autonomic_nervous1.34413847
38MP0002095_abnormal_skin_pigmentation1.32802821
39MP0005075_abnormal_melanosome_morpholog1.31888524
40MP0000313_abnormal_cell_death1.31119573
41MP0002019_abnormal_tumor_incidence1.31024839
42MP0006072_abnormal_retinal_apoptosis1.28079910
43MP0002102_abnormal_ear_morphology1.27439017
44MP0002398_abnormal_bone_marrow1.27420086
45MP0004264_abnormal_extraembryonic_tissu1.22603731
46MP0005389_reproductive_system_phenotype1.21823332
47MP0001730_embryonic_growth_arrest1.20090298
48MP0000703_abnormal_thymus_morphology1.19966148
49MP0001545_abnormal_hematopoietic_system1.19236623
50MP0005397_hematopoietic_system_phenotyp1.19236623
51MP0004233_abnormal_muscle_weight1.18485426
52MP0000566_synostosis1.16029503
53MP0001286_abnormal_eye_development1.15609046
54MP0001672_abnormal_embryogenesis/_devel1.14567334
55MP0005380_embryogenesis_phenotype1.14567334
56MP0001929_abnormal_gametogenesis1.13781277
57MP0000689_abnormal_spleen_morphology1.12949811
58MP0009703_decreased_birth_body1.11285975
59MP0000537_abnormal_urethra_morphology1.10228991
60MP0001145_abnormal_male_reproductive1.08291075
61MP0000653_abnormal_sex_gland1.07478663
62MP0001800_abnormal_humoral_immune1.07338512
63MP0002722_abnormal_immune_system1.06757402
64MP0003123_paternal_imprinting1.06176232
65MP0002452_abnormal_antigen_presenting1.03742996
66MP0000627_abnormal_mammary_gland1.01696564
67MP0005646_abnormal_pituitary_gland1.01492068
68MP0003936_abnormal_reproductive_system1.01355703
69MP0002277_abnormal_respiratory_mucosa1.01289602
70MP0002006_tumorigenesis1.01062836
71MP0001697_abnormal_embryo_size0.98643019
72MP0002420_abnormal_adaptive_immunity0.98014400
73MP0001819_abnormal_immune_cell0.97650575
74MP0003943_abnormal_hepatobiliary_system0.97174249
75MP0005671_abnormal_response_to0.96789026
76MP0009780_abnormal_chondrocyte_physiolo0.96544228
77MP0010352_gastrointestinal_tract_polyps0.96212880
78MP0001919_abnormal_reproductive_system0.96105460
79MP0003984_embryonic_growth_retardation0.96087256
80MP0002877_abnormal_melanocyte_morpholog0.95965155
81MP0002092_abnormal_eye_morphology0.95412920
82MP0001293_anophthalmia0.94922032
83MP0009785_altered_susceptibility_to0.94344703
84MP0002075_abnormal_coat/hair_pigmentati0.94297211
85MP0000716_abnormal_immune_system0.94148228
86MP0002098_abnormal_vibrissa_morphology0.94033717
87MP0009278_abnormal_bone_marrow0.92784122
88MP0001186_pigmentation_phenotype0.92596666
89MP0003315_abnormal_perineum_morphology0.92578413
90MP0002088_abnormal_embryonic_growth/wei0.92412186
91MP0002132_abnormal_respiratory_system0.92220496
92MP0002429_abnormal_blood_cell0.92179326
93MP0002085_abnormal_embryonic_tissue0.91494522
94MP0003890_abnormal_embryonic-extraembry0.91439581
95MP0003705_abnormal_hypodermis_morpholog0.89972947
96MP0009333_abnormal_splenocyte_physiolog0.88574067
97MP0002938_white_spotting0.87706863
98MP0000371_diluted_coat_color0.87334174
99MP0002723_abnormal_immune_serum0.86382078
100MP0003941_abnormal_skin_development0.86071384
101MP0002080_prenatal_lethality0.85929661
102MP0000428_abnormal_craniofacial_morphol0.85622031
103MP0002111_abnormal_tail_morphology0.85014860
104MP0005083_abnormal_biliary_tract0.84839226
105MP0002419_abnormal_innate_immunity0.83892366
106MP0000647_abnormal_sebaceous_gland0.83176934
107MP0003942_abnormal_urinary_system0.82625648
108MP0005408_hypopigmentation0.82463868
109MP0002148_abnormal_hypersensitivity_rea0.82431931
110MP0001727_abnormal_embryo_implantation0.82160923
111MP0005000_abnormal_immune_tolerance0.81082299
112MP0000858_altered_metastatic_potential0.81049277
113MP0005171_absent_coat_pigmentation0.80859122
114MP0001529_abnormal_vocalization0.80794388
115MP0003567_abnormal_fetal_cardiomyocyte0.79913379
116MP0000579_abnormal_nail_morphology0.79255891
117MP0008260_abnormal_autophagy0.79165165
118MP0003861_abnormal_nervous_system0.79080337
119MP0000358_abnormal_cell_content/0.78775573
120MP0004185_abnormal_adipocyte_glucose0.78689932
121MP0005391_vision/eye_phenotype0.78052553
122MP0003699_abnormal_female_reproductive0.77809442
123MP0002405_respiratory_system_inflammati0.76847080
124MP0008995_early_reproductive_senescence0.76167428
125MP0002086_abnormal_extraembryonic_tissu0.76064500
126MP0003698_abnormal_male_reproductive0.75912459
127MP0005025_abnormal_response_to0.75225803
128MP0004197_abnormal_fetal_growth/weight/0.74935565
129MP0002009_preneoplasia0.74840612
130MP0001873_stomach_inflammation0.74237772
131MP0003937_abnormal_limbs/digits/tail_de0.73922888
132MP0003935_abnormal_craniofacial_develop0.73808996
133MP0009053_abnormal_anal_canal0.71975724
134MP0003755_abnormal_palate_morphology0.71354548
135MP0001853_heart_inflammation0.70810775
136MP0005501_abnormal_skin_physiology0.67927797
137MP0000372_irregular_coat_pigmentation0.67578397
138MP0004147_increased_porphyrin_level0.67183579
139MP0002084_abnormal_developmental_patter0.66990329
140MP0003436_decreased_susceptibility_to0.66655713
141MP0002233_abnormal_nose_morphology0.66448753
142MP0002184_abnormal_innervation0.65940955
143MP0000377_abnormal_hair_follicle0.65638865
144MP0000631_abnormal_neuroendocrine_gland0.64329744
145MP0005187_abnormal_penis_morphology0.64040459

Predicted human phenotypes

RankGene SetZ-score
1* Chromosomal breakage induced by crosslinking agents (HP:0003221)6.51520008
2* Chromsome breakage (HP:0040012)6.50714032
3Birth length less than 3rd percentile (HP:0003561)4.93866318
4* Abnormality of chromosome stability (HP:0003220)4.14172878
5Duplicated collecting system (HP:0000081)3.74085471
6* Meckel diverticulum (HP:0002245)3.72302493
7Ectopic kidney (HP:0000086)3.67749231
8* Aplasia/Hypoplasia of the uvula (HP:0010293)3.63125633
9* Abnormality of the preputium (HP:0100587)3.62047430
10Abnormality of the renal collecting system (HP:0004742)3.60118764
11* Abnormality of the ileum (HP:0001549)3.53097047
12Asymmetry of the thorax (HP:0001555)3.31977004
13* Clubbing of toes (HP:0100760)3.27055336
14Patellar aplasia (HP:0006443)3.20074269
15Breast hypoplasia (HP:0003187)3.13275352
16Microglossia (HP:0000171)3.09744880
17Reticulocytopenia (HP:0001896)3.05872210
18Aplasia/Hypoplasia of the patella (HP:0006498)2.94721680
19* Duodenal stenosis (HP:0100867)2.94122009
20* Small intestinal stenosis (HP:0012848)2.94122009
21* Myelodysplasia (HP:0002863)2.83046030
22Abnormality of DNA repair (HP:0003254)2.76461231
23Prostate neoplasm (HP:0100787)2.73674479
24* Bone marrow hypocellularity (HP:0005528)2.72474163
25Impulsivity (HP:0100710)2.68139188
26Agnosia (HP:0010524)2.63527830
27* Abnormality of the carotid arteries (HP:0005344)2.60057420
28Medulloblastoma (HP:0002885)2.57138586
29Absent radius (HP:0003974)2.56626712
30* Sloping forehead (HP:0000340)2.51746960
31Volvulus (HP:0002580)2.44759306
32Absent frontal sinuses (HP:0002688)2.43891549
33Septate vagina (HP:0001153)2.43882911
34Nephroblastoma (Wilms tumor) (HP:0002667)2.43230653
35Absent thumb (HP:0009777)2.39165165
36Absent forearm bone (HP:0003953)2.37956187
37Aplasia involving forearm bones (HP:0009822)2.37956187
38Aplasia/Hypoplasia of the sacrum (HP:0008517)2.35864125
39Abnormality of the prostate (HP:0008775)2.35494153
40Aplastic anemia (HP:0001915)2.34169162
41* Arteriovenous malformation (HP:0100026)2.33825283
42Glioma (HP:0009733)2.32916916
43* Abnormality of the duodenum (HP:0002246)2.32607979
44Abnormal lung lobation (HP:0002101)2.32478939
45Embryonal neoplasm (HP:0002898)2.32101671
46Abnormality of the fingertips (HP:0001211)2.27718538
47Selective tooth agenesis (HP:0001592)2.25003736
48Embryonal renal neoplasm (HP:0011794)2.23608784
49* Cafe-au-lait spot (HP:0000957)2.23252657
50Hypoplasia of the capital femoral epiphysis (HP:0003090)2.21584300
51Aplasia/Hypoplasia of the earlobes (HP:0009906)2.18612858
52Neoplasm of the adrenal cortex (HP:0100641)2.16099575
53Colon cancer (HP:0003003)2.15644949
54* Short thumb (HP:0009778)2.14751108
55Acute myeloid leukemia (HP:0004808)2.14458112
56Oral leukoplakia (HP:0002745)2.13365224
57Abnormality of the pons (HP:0007361)2.11173219
58Hypopigmentation of the fundus (HP:0007894)2.10437943
59Premature graying of hair (HP:0002216)2.07976685
60Abnormality of the labia minora (HP:0012880)2.07969006
61Lymphoma (HP:0002665)2.06492365
62Hypoplasia of the pons (HP:0012110)2.06295578
63Ependymoma (HP:0002888)2.04425915
64Recurrent abscess formation (HP:0002722)2.04180476
65Abnormal number of incisors (HP:0011064)2.02067939
66Thyroid carcinoma (HP:0002890)2.01468800
67Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.99071664
68Cutaneous melanoma (HP:0012056)1.98609947
69Abnormality of the anterior horn cell (HP:0006802)1.97951359
70Degeneration of anterior horn cells (HP:0002398)1.97951359
71Abnormal spermatogenesis (HP:0008669)1.97381615
72Carpal bone hypoplasia (HP:0001498)1.97209328
73* Triphalangeal thumb (HP:0001199)1.96411140
74Optic nerve coloboma (HP:0000588)1.94883728
75Optic neuritis (HP:0100653)1.93060684
76Retrobulbar optic neuritis (HP:0100654)1.93060684
77* Tracheoesophageal fistula (HP:0002575)1.92341689
78Acute lymphatic leukemia (HP:0006721)1.91241325
79Abnormality of pyrimidine metabolism (HP:0004353)1.91086121
80Granulocytopenia (HP:0001913)1.91056876
81Horseshoe kidney (HP:0000085)1.91011358
82Type I transferrin isoform profile (HP:0003642)1.90082873
83* Choanal atresia (HP:0000453)1.89870228
84Bifid tongue (HP:0010297)1.88032359
85Prominent nose (HP:0000448)1.86867724
86J-shaped sella turcica (HP:0002680)1.85169081
87Cortical dysplasia (HP:0002539)1.84947270
88* Leukopenia (HP:0001882)1.84922616
89* Astigmatism (HP:0000483)1.84480476
90Combined immunodeficiency (HP:0005387)1.84377048
91* Breast carcinoma (HP:0003002)1.84229267
92Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.84145104
93High anterior hairline (HP:0009890)1.83756045
94Bilateral microphthalmos (HP:0007633)1.83308171
95Hypergonadotropic hypogonadism (HP:0000815)1.82378747
96IgM deficiency (HP:0002850)1.82220258
97Papillary thyroid carcinoma (HP:0002895)1.81868449
98Aplasia/Hypoplasia of the tongue (HP:0010295)1.81653364
99Cellular immunodeficiency (HP:0005374)1.80670538
100Pulmonary fibrosis (HP:0002206)1.80619702
101Severe combined immunodeficiency (HP:0004430)1.80112845
102Sandal gap (HP:0001852)1.79839589
103Aplasia/Hypoplasia of the sternum (HP:0006714)1.78763323
104Deep philtrum (HP:0002002)1.78253180
105Meningioma (HP:0002858)1.76472038
106High pitched voice (HP:0001620)1.76382541
107Abnormality of the astrocytes (HP:0100707)1.75468851
108Astrocytoma (HP:0009592)1.75468851
109Myositis (HP:0100614)1.74980549
110Cerebellar dysplasia (HP:0007033)1.73895165
111Midline defect of the nose (HP:0004122)1.73504443
112Pancytopenia (HP:0001876)1.73466605
113Abnormality of cochlea (HP:0000375)1.73376013
114Rhabdomyosarcoma (HP:0002859)1.73299826
115Type 2 muscle fiber atrophy (HP:0003554)1.71980728
116Partial agenesis of the corpus callosum (HP:0001338)1.71442363
117Duplication of thumb phalanx (HP:0009942)1.69548011
118Supernumerary spleens (HP:0009799)1.69365534
119Amaurosis fugax (HP:0100576)1.69350573
120Abnormal umbilical cord blood vessels (HP:0011403)1.69002159
121Single umbilical artery (HP:0001195)1.69002159
122Abnormality of the fetal cardiovascular system (HP:0010948)1.69002159
123Microretrognathia (HP:0000308)1.68896794
124Recurrent bacterial skin infections (HP:0005406)1.68513945
125Increased nuchal translucency (HP:0010880)1.68246879
126Eosinophilia (HP:0001880)1.68210349
127B lymphocytopenia (HP:0010976)1.68209231
128Abnormality of B cell number (HP:0010975)1.68209231
129Recurrent pneumonia (HP:0006532)1.67900659
130Cleft eyelid (HP:0000625)1.67766238
131Mediastinal lymphadenopathy (HP:0100721)1.67161589
132Abnormality of chromosome segregation (HP:0002916)1.64360711
133Gastrointestinal carcinoma (HP:0002672)1.64202723
134Malignant gastrointestinal tract tumors (HP:0006749)1.64202723
135Absent epiphyses (HP:0010577)1.63677897
136Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.63677897
137Abnormality of the incisor (HP:0000676)1.63649462
138Neoplasm of the pancreas (HP:0002894)1.63601770
139Rough bone trabeculation (HP:0100670)1.63056473
140Facial cleft (HP:0002006)1.62253436
141Proximal placement of thumb (HP:0009623)1.61850161
142Neoplasm of striated muscle (HP:0009728)1.61172702
143Thyroiditis (HP:0100646)1.61023896
14411 pairs of ribs (HP:0000878)1.60132813
145Abnormality of the proximal phalanges of the hand (HP:0009834)1.60093426
146Microtia (HP:0008551)1.59706076
147Bicornuate uterus (HP:0000813)1.59317130
148Dandy-Walker malformation (HP:0001305)1.56435782
149Abnormality of the frontal sinuses (HP:0002687)1.56144967
150* Oligohydramnios (HP:0001562)1.54815583
151Leiomyosarcoma (HP:0100243)1.54729522
152Uterine leiomyosarcoma (HP:0002891)1.54729522
153Microvesicular hepatic steatosis (HP:0001414)1.54438211
154Deviation of the thumb (HP:0009603)1.54211352
155Concave nail (HP:0001598)1.52517600

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.40989974
2PLK44.08662992
3SRPK13.42735608
4SCYL23.23873700
5ZAK3.19334977
6WEE12.91830456
7TTK2.71476427
8BUB12.67732620
9EIF2AK12.44078478
10BRSK22.37546711
11PIK3CA2.19025167
12NEK22.16973265
13VRK12.16021152
14IRAK42.12034694
15PLK12.09907725
16TAF12.09163007
17ATR2.06976528
18STK42.00404067
19IRAK32.00186854
20ACVR1B1.99843418
21MKNK11.92604924
22TLK11.88909825
23CHEK21.83307515
24EIF2AK31.81519041
25MKNK21.81388095
26CCNB11.75436017
27PLK31.75148633
28AURKB1.72216356
29VRK21.65668256
30EIF2AK21.59808359
31STK161.59694537
32PKN21.48757262
33CDK71.47607858
34FRK1.42358466
35PNCK1.39061765
36PASK1.36247200
37TRIM281.30981316
38BRSK11.30260155
39NEK91.27441032
40CDK121.26825350
41TXK1.23866117
42EEF2K1.21240810
43TSSK61.20346477
44YES11.19816813
45SMG11.15389917
46CHEK11.12837804
47MAP3K141.10266081
48AURKA1.09322195
49TEC1.08449515
50ATM1.06076843
51CDK81.05040251
52CLK11.04507698
53STK101.03902787
54RPS6KA41.02038749
55CDK41.01419657
56PIM10.95773940
57TRIB30.93579525
58MAP3K100.93122569
59DYRK30.85353469
60ERBB30.85120977
61MAPKAPK30.84526275
62BRD40.80942884
63MAP3K80.80331221
64STK38L0.77869145
65NEK60.76885176
66CDK20.75933615
67STK390.74906858
68NEK10.73794746
69BRAF0.72053611
70BTK0.71780594
71STK30.71432765
72CDK90.70602788
73BMPR1B0.70260218
74MAP3K120.69905477
75MELK0.69533867
76CDK60.69323273
77MUSK0.69259200
78CDK10.68715392
79AKT30.66956130
80CAMK1G0.66392041
81PLK20.65629120
82RPS6KB20.64940445
83BMPR20.64362900
84TGFBR10.63608907
85CDK30.61448314
86CHUK0.61139618
87MAP4K20.60964016
88MAP3K60.60947628
89PBK0.59639745
90RPS6KA50.59629124
91KIT0.59525533
92MST40.59386275
93FGFR20.57580519
94JAK30.56047883
95NUAK10.55894589
96SIK30.55841336
97MAP4K10.55430751
98CSNK2A10.54508248
99MAP2K20.54059239
100CAMK1D0.52171634
101IKBKB0.51442629
102TAOK30.48650228
103WNK30.47424957
104PRKCI0.46817380
105TRPM70.45886136
106EPHA20.41609752
107LYN0.41252377
108INSRR0.39679009
109CSNK1D0.39553901
110SGK20.39464487
111NME20.38752304
112CSNK2A20.38046974
113BCR0.37542716
114WNK40.37518006
115AKT20.37473726
116CSNK1E0.37196384
117IRAK10.36109062
118MAPK140.36052585
119MTOR0.35471309
120EPHA30.35374294
121SIK10.34855655
122FGFR10.34410641
123NLK0.30773424
124CSNK1G10.30541789
125PRKDC0.28601546
126ADRBK20.28314473
127AKT10.26835903
128IKBKE0.26747996
129GSK3B0.25234735
130RPS6KB10.25050098
131TYK20.23303661
132PAK40.22682842
133CSF1R0.20447628
134TNIK0.20370235
135LATS10.19878818

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.25584662
2Mismatch repair_Homo sapiens_hsa034304.71110061
3Homologous recombination_Homo sapiens_hsa034403.66187048
4Base excision repair_Homo sapiens_hsa034103.41378510
5* Fanconi anemia pathway_Homo sapiens_hsa034603.39413285
6Cell cycle_Homo sapiens_hsa041103.15533948
7Non-homologous end-joining_Homo sapiens_hsa034502.86059106
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.85209844
9Nucleotide excision repair_Homo sapiens_hsa034202.81268503
10Spliceosome_Homo sapiens_hsa030402.59232338
11One carbon pool by folate_Homo sapiens_hsa006702.41542760
12RNA transport_Homo sapiens_hsa030132.34985937
13RNA polymerase_Homo sapiens_hsa030202.34293289
14Pyrimidine metabolism_Homo sapiens_hsa002402.21425958
15RNA degradation_Homo sapiens_hsa030181.98046284
16Proteasome_Homo sapiens_hsa030501.97044284
17Basal transcription factors_Homo sapiens_hsa030221.94452026
18p53 signaling pathway_Homo sapiens_hsa041151.88310126
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.64876635
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.62719293
21Systemic lupus erythematosus_Homo sapiens_hsa053221.55717804
22mRNA surveillance pathway_Homo sapiens_hsa030151.52793435
23Ribosome_Homo sapiens_hsa030101.41504308
24Herpes simplex infection_Homo sapiens_hsa051681.35719782
25Purine metabolism_Homo sapiens_hsa002301.24261796
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16136009
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.13604483
28Epstein-Barr virus infection_Homo sapiens_hsa051691.12636297
29Primary immunodeficiency_Homo sapiens_hsa053401.10310365
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09370184
31Viral carcinogenesis_Homo sapiens_hsa052031.03481038
32Measles_Homo sapiens_hsa051621.02366652
33Steroid biosynthesis_Homo sapiens_hsa001001.01915911
34Intestinal immune network for IgA production_Homo sapiens_hsa046720.85224654
35Hippo signaling pathway_Homo sapiens_hsa043900.83211885
36Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82006412
37NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80742292
38HTLV-I infection_Homo sapiens_hsa051660.80667179
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77920713
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76574662
41MicroRNAs in cancer_Homo sapiens_hsa052060.75833432
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75373167
43Legionellosis_Homo sapiens_hsa051340.73819244
44Folate biosynthesis_Homo sapiens_hsa007900.73424242
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72598875
46Hematopoietic cell lineage_Homo sapiens_hsa046400.71940893
47Oocyte meiosis_Homo sapiens_hsa041140.71492687
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71116488
49Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70790336
50Antigen processing and presentation_Homo sapiens_hsa046120.70269513
51Allograft rejection_Homo sapiens_hsa053300.68175396
52Influenza A_Homo sapiens_hsa051640.67831398
53Propanoate metabolism_Homo sapiens_hsa006400.67522925
54Leishmaniasis_Homo sapiens_hsa051400.66645226
55Small cell lung cancer_Homo sapiens_hsa052220.65593805
56Hepatitis B_Homo sapiens_hsa051610.63770758
57Graft-versus-host disease_Homo sapiens_hsa053320.61741521
58Autoimmune thyroid disease_Homo sapiens_hsa053200.61538453
59Apoptosis_Homo sapiens_hsa042100.60996911
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60838825
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58320836
62Bladder cancer_Homo sapiens_hsa052190.56693008
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56646864
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56264757
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.56124632
66Biosynthesis of amino acids_Homo sapiens_hsa012300.55792076
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53726267
68Alcoholism_Homo sapiens_hsa050340.53199762
69Asthma_Homo sapiens_hsa053100.51975432
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48255294
71Caffeine metabolism_Homo sapiens_hsa002320.46613754
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45201273
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.45080422
74Pyruvate metabolism_Homo sapiens_hsa006200.44840184
75Non-small cell lung cancer_Homo sapiens_hsa052230.44728220
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.42169918
77Arachidonic acid metabolism_Homo sapiens_hsa005900.41592831
78Fatty acid elongation_Homo sapiens_hsa000620.41531899
79Endometrial cancer_Homo sapiens_hsa052130.40787161
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40726137
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40373350
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40274808
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40242504
84Shigellosis_Homo sapiens_hsa051310.39862587
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39592858
86Pancreatic cancer_Homo sapiens_hsa052120.39160671
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38214433
88Protein export_Homo sapiens_hsa030600.38098938
89N-Glycan biosynthesis_Homo sapiens_hsa005100.38033077
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.37779536
91Glioma_Homo sapiens_hsa052140.37163935
92Wnt signaling pathway_Homo sapiens_hsa043100.36979397
93Vitamin B6 metabolism_Homo sapiens_hsa007500.35970561
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35766665
95Hedgehog signaling pathway_Homo sapiens_hsa043400.35714925
96Colorectal cancer_Homo sapiens_hsa052100.35618551
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35196962
98TNF signaling pathway_Homo sapiens_hsa046680.35023605
99Tight junction_Homo sapiens_hsa045300.34830514
100mTOR signaling pathway_Homo sapiens_hsa041500.34201158
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33730661
102Nitrogen metabolism_Homo sapiens_hsa009100.33590868
103TGF-beta signaling pathway_Homo sapiens_hsa043500.33422698
104Selenocompound metabolism_Homo sapiens_hsa004500.33084065
105Phototransduction_Homo sapiens_hsa047440.33027804
106FoxO signaling pathway_Homo sapiens_hsa040680.30612746
107Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30204326
108AMPK signaling pathway_Homo sapiens_hsa041520.27961463
109Chronic myeloid leukemia_Homo sapiens_hsa052200.27632541
110Butanoate metabolism_Homo sapiens_hsa006500.27619754
111Prostate cancer_Homo sapiens_hsa052150.26882574
112Notch signaling pathway_Homo sapiens_hsa043300.26409387
113Metabolic pathways_Homo sapiens_hsa011000.26239760
114Pathways in cancer_Homo sapiens_hsa052000.25471354
115ErbB signaling pathway_Homo sapiens_hsa040120.25441132
116Basal cell carcinoma_Homo sapiens_hsa052170.25084030
117Viral myocarditis_Homo sapiens_hsa054160.24616660
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23408519
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23178112
120Inositol phosphate metabolism_Homo sapiens_hsa005620.22893293
121Pentose phosphate pathway_Homo sapiens_hsa000300.22676723
122Lysine degradation_Homo sapiens_hsa003100.21983941
123Tuberculosis_Homo sapiens_hsa051520.21854456
124Type I diabetes mellitus_Homo sapiens_hsa049400.21716299
125Malaria_Homo sapiens_hsa051440.20918862
126Pertussis_Homo sapiens_hsa051330.20848726
127Thyroid cancer_Homo sapiens_hsa052160.20601339
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19984988
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.19370619
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19347951
131Other glycan degradation_Homo sapiens_hsa005110.18679934
132Toxoplasmosis_Homo sapiens_hsa051450.18618742
133B cell receptor signaling pathway_Homo sapiens_hsa046620.18511794
134Huntingtons disease_Homo sapiens_hsa050160.18275177
135Melanoma_Homo sapiens_hsa052180.18220270
136Carbon metabolism_Homo sapiens_hsa012000.17742440
137Tryptophan metabolism_Homo sapiens_hsa003800.17248434
138Cysteine and methionine metabolism_Homo sapiens_hsa002700.16829249
139Osteoclast differentiation_Homo sapiens_hsa043800.16470405
140Adherens junction_Homo sapiens_hsa045200.16004113
141Sulfur relay system_Homo sapiens_hsa041220.15474992
142Glutathione metabolism_Homo sapiens_hsa004800.15400348
143Maturity onset diabetes of the young_Homo sapiens_hsa049500.14989452
144Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.14371736
145Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.13429407

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