| 1 | Birth length less than 3rd percentile (HP:0003561) | 6.10514833 |
| 2 | Breast hypoplasia (HP:0003187) | 5.00193537 |
| 3 | Acute necrotizing encephalopathy (HP:0006965) | 3.94812469 |
| 4 | Carpal bone hypoplasia (HP:0001498) | 3.88723603 |
| 5 | Patellar aplasia (HP:0006443) | 3.78422123 |
| 6 | Acute encephalopathy (HP:0006846) | 3.76631905 |
| 7 | Chromsome breakage (HP:0040012) | 3.76319595 |
| 8 | Cerebral hypomyelination (HP:0006808) | 3.73793939 |
| 9 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.71677943 |
| 10 | Reticulocytopenia (HP:0001896) | 3.70571404 |
| 11 | Oral leukoplakia (HP:0002745) | 3.60812329 |
| 12 | Rough bone trabeculation (HP:0100670) | 3.60073569 |
| 13 | Increased CSF lactate (HP:0002490) | 3.58355545 |
| 14 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.57693716 |
| 15 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.54609905 |
| 16 | Mitochondrial inheritance (HP:0001427) | 3.44236545 |
| 17 | Increased hepatocellular lipid droplets (HP:0006565) | 3.39534429 |
| 18 | Hepatocellular necrosis (HP:0001404) | 3.31795881 |
| 19 | Abnormality of the anterior horn cell (HP:0006802) | 3.30470590 |
| 20 | Degeneration of anterior horn cells (HP:0002398) | 3.30470590 |
| 21 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.29016424 |
| 22 | Progressive macrocephaly (HP:0004481) | 3.19867956 |
| 23 | Meckel diverticulum (HP:0002245) | 3.17862532 |
| 24 | Abnormality of the preputium (HP:0100587) | 3.17524606 |
| 25 | Absent radius (HP:0003974) | 3.16891233 |
| 26 | Abnormal number of erythroid precursors (HP:0012131) | 3.12436858 |
| 27 | Lipid accumulation in hepatocytes (HP:0006561) | 3.10899341 |
| 28 | Cerebral edema (HP:0002181) | 3.09527164 |
| 29 | Abnormality of chromosome stability (HP:0003220) | 3.08170530 |
| 30 | Impulsivity (HP:0100710) | 2.98862208 |
| 31 | Abnormality of the ileum (HP:0001549) | 2.97612770 |
| 32 | Abnormality of the labia minora (HP:0012880) | 2.97548132 |
| 33 | Absent forearm bone (HP:0003953) | 2.95779767 |
| 34 | Aplasia involving forearm bones (HP:0009822) | 2.95779767 |
| 35 | Hepatic necrosis (HP:0002605) | 2.95215159 |
| 36 | Aplastic anemia (HP:0001915) | 2.80263613 |
| 37 | Colon cancer (HP:0003003) | 2.78846054 |
| 38 | Macrocytic anemia (HP:0001972) | 2.75901242 |
| 39 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.70901332 |
| 40 | Supernumerary spleens (HP:0009799) | 2.70679768 |
| 41 | Abnormal trabecular bone morphology (HP:0100671) | 2.70564842 |
| 42 | Secondary amenorrhea (HP:0000869) | 2.65940424 |
| 43 | Selective tooth agenesis (HP:0001592) | 2.64486018 |
| 44 | Volvulus (HP:0002580) | 2.64174589 |
| 45 | Premature graying of hair (HP:0002216) | 2.63711799 |
| 46 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.62379081 |
| 47 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.62139853 |
| 48 | Abnormality of alanine metabolism (HP:0010916) | 2.62139853 |
| 49 | Hyperalaninemia (HP:0003348) | 2.62139853 |
| 50 | Multiple enchondromatosis (HP:0005701) | 2.62067781 |
| 51 | Horseshoe kidney (HP:0000085) | 2.61796204 |
| 52 | Absent thumb (HP:0009777) | 2.61544680 |
| 53 | Premature ovarian failure (HP:0008209) | 2.57636851 |
| 54 | Trismus (HP:0000211) | 2.53378736 |
| 55 | Irregular epiphyses (HP:0010582) | 2.51700815 |
| 56 | Abnormality of methionine metabolism (HP:0010901) | 2.51263690 |
| 57 | Small intestinal stenosis (HP:0012848) | 2.51168465 |
| 58 | Duodenal stenosis (HP:0100867) | 2.51168465 |
| 59 | Abnormal lung lobation (HP:0002101) | 2.50710042 |
| 60 | Microvesicular hepatic steatosis (HP:0001414) | 2.47646855 |
| 61 | Microretrognathia (HP:0000308) | 2.44743988 |
| 62 | Myelodysplasia (HP:0002863) | 2.43216187 |
| 63 | Bone marrow hypocellularity (HP:0005528) | 2.42819131 |
| 64 | Lactic acidosis (HP:0003128) | 2.42747530 |
| 65 | Abnormality of the pons (HP:0007361) | 2.41765422 |
| 66 | Medulloblastoma (HP:0002885) | 2.39653885 |
| 67 | Abnormal spermatogenesis (HP:0008669) | 2.37179832 |
| 68 | Cleft eyelid (HP:0000625) | 2.35240437 |
| 69 | Hypoplasia of the pons (HP:0012110) | 2.34920150 |
| 70 | Muscle fiber atrophy (HP:0100295) | 2.33856739 |
| 71 | Type 2 muscle fiber atrophy (HP:0003554) | 2.31122606 |
| 72 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 2.28001450 |
| 73 | Increased intramyocellular lipid droplets (HP:0012240) | 2.24728306 |
| 74 | Pallor (HP:0000980) | 2.24718614 |
| 75 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.23472680 |
| 76 | Abnormality of the carotid arteries (HP:0005344) | 2.22955930 |
| 77 | Clubbing of toes (HP:0100760) | 2.22944351 |
| 78 | Renal Fanconi syndrome (HP:0001994) | 2.22647842 |
| 79 | Sparse eyelashes (HP:0000653) | 2.22571662 |
| 80 | Triphalangeal thumb (HP:0001199) | 2.22015746 |
| 81 | Abnormality of serum amino acid levels (HP:0003112) | 2.20418324 |
| 82 | CNS hypomyelination (HP:0003429) | 2.17634169 |
| 83 | Embryonal renal neoplasm (HP:0011794) | 2.16588711 |
| 84 | Sloping forehead (HP:0000340) | 2.16199312 |
| 85 | Neoplasm of the pancreas (HP:0002894) | 2.15913074 |
| 86 | Exercise intolerance (HP:0003546) | 2.14189981 |
| 87 | Cellular immunodeficiency (HP:0005374) | 2.10990393 |
| 88 | Respiratory failure (HP:0002878) | 2.10751534 |
| 89 | 11 pairs of ribs (HP:0000878) | 2.10525772 |
| 90 | Agnosia (HP:0010524) | 2.10426390 |
| 91 | 3-Methylglutaconic aciduria (HP:0003535) | 2.09648377 |
| 92 | Atresia of the external auditory canal (HP:0000413) | 2.09007075 |
| 93 | Ectopic kidney (HP:0000086) | 2.08247936 |
| 94 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.06875606 |
| 95 | Leukodystrophy (HP:0002415) | 2.06331566 |
| 96 | Short thumb (HP:0009778) | 2.05672979 |
| 97 | Abnormality of the duodenum (HP:0002246) | 2.04728540 |
| 98 | Hypoplasia of the radius (HP:0002984) | 2.04614867 |
| 99 | Rhabdomyosarcoma (HP:0002859) | 2.03777568 |
| 100 | Glossoptosis (HP:0000162) | 2.01932986 |
| 101 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.00271701 |
| 102 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.00271701 |
| 103 | Abnormal protein glycosylation (HP:0012346) | 2.00271701 |
| 104 | Abnormal glycosylation (HP:0012345) | 2.00271701 |
| 105 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.00014912 |
| 106 | Type I transferrin isoform profile (HP:0003642) | 1.99956937 |
| 107 | Tracheoesophageal fistula (HP:0002575) | 1.99704125 |
| 108 | Methylmalonic acidemia (HP:0002912) | 1.99625517 |
| 109 | Ureteral duplication (HP:0000073) | 1.99519705 |
| 110 | Respiratory difficulties (HP:0002880) | 1.98376812 |
| 111 | Abnormality of the renal collecting system (HP:0004742) | 1.96386951 |
| 112 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.96132340 |
| 113 | Lethargy (HP:0001254) | 1.95669275 |
| 114 | Ependymoma (HP:0002888) | 1.95239785 |
| 115 | Squamous cell carcinoma (HP:0002860) | 1.93224017 |
| 116 | Duplicated collecting system (HP:0000081) | 1.92803257 |
| 117 | Reduced antithrombin III activity (HP:0001976) | 1.90864109 |
| 118 | Increased nuchal translucency (HP:0010880) | 1.90680845 |
| 119 | Megaloblastic anemia (HP:0001889) | 1.90587778 |
| 120 | Pancytopenia (HP:0001876) | 1.90473131 |
| 121 | Congenital, generalized hypertrichosis (HP:0004540) | 1.90342465 |
| 122 | Facial hemangioma (HP:0000329) | 1.90282301 |
| 123 | Abnormality of the umbilical cord (HP:0010881) | 1.89130344 |
| 124 | Neoplasm of the colon (HP:0100273) | 1.87299408 |
| 125 | Stenosis of the external auditory canal (HP:0000402) | 1.87168748 |
| 126 | Breast aplasia (HP:0100783) | 1.86801809 |
| 127 | Abnormality of glycolysis (HP:0004366) | 1.83548311 |
| 128 | Increased serum pyruvate (HP:0003542) | 1.83548311 |
| 129 | Hyperglycinemia (HP:0002154) | 1.83298040 |
| 130 | Facial cleft (HP:0002006) | 1.82698140 |
| 131 | CNS demyelination (HP:0007305) | 1.82620773 |
| 132 | Increased serum lactate (HP:0002151) | 1.82577605 |
| 133 | Entropion (HP:0000621) | 1.81753272 |
| 134 | Aplasia/Hypoplasia of the breasts (HP:0010311) | 1.80607709 |
| 135 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.77736860 |
| 136 | Progressive muscle weakness (HP:0003323) | 1.77732656 |
| 137 | Median cleft lip (HP:0000161) | 1.77490264 |
| 138 | Short tibia (HP:0005736) | 1.76731104 |
| 139 | Capillary hemangiomas (HP:0005306) | 1.76572184 |
| 140 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.75902803 |
| 141 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.75902803 |
| 142 | Abnormal number of incisors (HP:0011064) | 1.74987199 |
| 143 | Abnormality of homocysteine metabolism (HP:0010919) | 1.74968683 |
| 144 | Homocystinuria (HP:0002156) | 1.74968683 |
| 145 | Sensory axonal neuropathy (HP:0003390) | 1.74269513 |
| 146 | Absent epiphyses (HP:0010577) | 1.73483497 |
| 147 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 1.73483497 |
| 148 | Aplasia/hypoplasia of the humerus (HP:0006507) | 1.73186146 |
| 149 | Increased muscle lipid content (HP:0009058) | 1.71783260 |
| 150 | Slender long bone (HP:0003100) | 1.71687672 |
| 151 | Stillbirth (HP:0003826) | 1.71423741 |
| 152 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.71031446 |
| 153 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.70676211 |
BRIX1 
