BRK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.49486541
2translational termination (GO:0006415)6.24563383
3protein targeting to ER (GO:0045047)6.11307622
4establishment of protein localization to endoplasmic reticulum (GO:0072599)5.88409318
5establishment of protein localization to mitochondrial membrane (GO:0090151)5.88138011
6protein localization to endoplasmic reticulum (GO:0070972)5.85174927
7translational elongation (GO:0006414)5.34531521
8viral life cycle (GO:0019058)5.02830499
9cellular protein complex disassembly (GO:0043624)4.86862611
10ribosomal small subunit biogenesis (GO:0042274)4.66957134
11translational initiation (GO:0006413)4.60592393
12nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.59888088
13hydrogen ion transmembrane transport (GO:1902600)4.50101140
14ribosomal large subunit biogenesis (GO:0042273)4.49821992
15ATP biosynthetic process (GO:0006754)4.44930952
16neutrophil activation involved in immune response (GO:0002283)4.42134350
17mitochondrial respiratory chain complex assembly (GO:0033108)4.35635137
18translation (GO:0006412)4.29520885
19protein targeting to membrane (GO:0006612)4.17311262
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.17076716
21mitochondrial respiratory chain complex I assembly (GO:0032981)4.17076716
22NADH dehydrogenase complex assembly (GO:0010257)4.17076716
23purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.13195833
24purine nucleoside triphosphate biosynthetic process (GO:0009145)4.12788408
25antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)4.11707651
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.09165608
27maturation of SSU-rRNA (GO:0030490)4.08481763
28protein complex disassembly (GO:0043241)4.07976264
29ribosomal small subunit assembly (GO:0000028)4.06172832
30proton transport (GO:0015992)4.01629817
31hydrogen transport (GO:0006818)3.93627313
32macromolecular complex disassembly (GO:0032984)3.91777454
33Arp2/3 complex-mediated actin nucleation (GO:0034314)3.84628099
34regulation of mitochondrial translation (GO:0070129)3.73920046
35oxidative phosphorylation (GO:0006119)3.73117797
36negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.66429603
37ribonucleoside triphosphate biosynthetic process (GO:0009201)3.64227283
38platelet dense granule organization (GO:0060155)3.61578409
39protein localization to mitochondrion (GO:0070585)3.56999703
40rRNA modification (GO:0000154)3.50410340
41cullin deneddylation (GO:0010388)3.48956970
42phagosome maturation (GO:0090382)3.46469049
43protein deneddylation (GO:0000338)3.45905390
44regulation of cellular amino acid metabolic process (GO:0006521)3.44665932
45inner mitochondrial membrane organization (GO:0007007)3.43792115
46nucleoside triphosphate biosynthetic process (GO:0009142)3.41587646
47DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.38300659
48positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.37156948
49sequestering of actin monomers (GO:0042989)3.35249589
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.32679919
51respiratory burst (GO:0045730)3.31905899
52proteasome assembly (GO:0043248)3.30253703
53mitochondrial transport (GO:0006839)3.29114292
54intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.28511082
55signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.28511082
56antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.28080037
57signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.25573372
58signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.25573372
59signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.25573372
60DNA deamination (GO:0045006)3.24865440
61negative regulation of ligase activity (GO:0051352)3.24820327
62negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.24820327
63regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.21248571
64protein neddylation (GO:0045116)3.19402772
65establishment of protein localization to membrane (GO:0090150)3.18078761
66cytochrome complex assembly (GO:0017004)3.16961705
67nuclear-transcribed mRNA catabolic process (GO:0000956)3.15764487
68RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.14012045
69tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.14012045
70mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.13806233
71GTP biosynthetic process (GO:0006183)3.12701289
72aldehyde catabolic process (GO:0046185)3.11509578
73signal transduction involved in DNA integrity checkpoint (GO:0072401)3.11378478
74signal transduction involved in DNA damage checkpoint (GO:0072422)3.11378478
75signal peptide processing (GO:0006465)3.11348473
76cellular component biogenesis (GO:0044085)3.11348330
77regulation of T-helper 1 cell differentiation (GO:0045625)3.08088204
78purine nucleoside monophosphate biosynthetic process (GO:0009127)3.07487194
79purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.07487194
80regulation of B cell receptor signaling pathway (GO:0050855)3.06701134
81signal transduction involved in cell cycle checkpoint (GO:0072395)3.04853025
82protein targeting (GO:0006605)3.04643639
83intracellular protein transmembrane import (GO:0044743)3.02528946
84aerobic respiration (GO:0009060)3.02147959
85anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.01059141
86ATP synthesis coupled proton transport (GO:0015986)2.98459965
87energy coupled proton transport, down electrochemical gradient (GO:0015985)2.98459965
88establishment of integrated proviral latency (GO:0075713)2.97885182
89transferrin transport (GO:0033572)2.97392691
90mRNA catabolic process (GO:0006402)2.95533657
91mast cell activation (GO:0045576)2.94037364
92actin nucleation (GO:0045010)2.93781904
93positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.93021055
94cellular response to interferon-beta (GO:0035458)2.91245494
95neutrophil activation (GO:0042119)2.90353285
96guanosine-containing compound biosynthetic process (GO:1901070)2.89960832
97regulation of oxidative phosphorylation (GO:0002082)2.89489145
98cellular response to zinc ion (GO:0071294)2.87916867
99negative regulation of myeloid cell apoptotic process (GO:0033033)2.86337257
100eosinophil chemotaxis (GO:0048245)2.85505527
101immunoglobulin mediated immune response (GO:0016064)2.84464828
102negative regulation of interleukin-17 production (GO:0032700)2.84447267
103granulocyte activation (GO:0036230)2.83761490
104ATP hydrolysis coupled proton transport (GO:0015991)2.82179689
105energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.82179689
106respiratory chain complex IV assembly (GO:0008535)2.81675773
107positive regulation of ligase activity (GO:0051351)2.81589759
108response to peptidoglycan (GO:0032494)2.73007298
109transcription elongation from RNA polymerase III promoter (GO:0006385)2.71137931
110termination of RNA polymerase III transcription (GO:0006386)2.71137931
111response to interferon-beta (GO:0035456)2.66214379
112leukocyte degranulation (GO:0043299)2.65456150
113positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.63747458
114L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.63273412
115protein complex biogenesis (GO:0070271)2.62051595
116myeloid cell activation involved in immune response (GO:0002275)2.62001803
117chaperone-mediated protein transport (GO:0072321)2.61212474
118trivalent inorganic cation transport (GO:0072512)2.60003119
119ferric iron transport (GO:0015682)2.60003119
120regulation of cellular amine metabolic process (GO:0033238)2.58303662
121positive regulation of cell cycle arrest (GO:0071158)2.58053830
122myeloid dendritic cell activation (GO:0001773)2.56892473
123positive regulation of antigen processing and presentation (GO:0002579)2.56436062
124endosome to melanosome transport (GO:0035646)2.55091170
125endosome to pigment granule transport (GO:0043485)2.55091170
126nucleobase-containing small molecule interconversion (GO:0015949)2.54961185
127protein maturation by protein folding (GO:0022417)2.54476973
128eosinophil migration (GO:0072677)2.52062661
129NIK/NF-kappaB signaling (GO:0038061)2.51698061
130leukocyte mediated cytotoxicity (GO:0001909)2.51321243
131positive regulation of mitochondrial fission (GO:0090141)2.51248676
132myeloid dendritic cell differentiation (GO:0043011)2.49113222
133negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.48507382
134deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.47783001
135respiratory electron transport chain (GO:0022904)2.47018791
136B cell mediated immunity (GO:0019724)2.45846117
137protein targeting to mitochondrion (GO:0006626)2.45271347
138electron transport chain (GO:0022900)2.41766393
139mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.41124353
140regulation of ubiquitin-protein transferase activity (GO:0051438)2.40810960
141SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.36978003
142positive regulation of monocyte chemotaxis (GO:0090026)2.36768671
143mast cell activation involved in immune response (GO:0002279)2.35393482
144mast cell degranulation (GO:0043303)2.35393482
145interferon-gamma-mediated signaling pathway (GO:0060333)2.34658990
146regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.34497190
147cotranslational protein targeting to membrane (GO:0006613)2.34325580
148negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.34104294
149establishment of protein localization to mitochondrion (GO:0072655)2.34021750
1502-deoxyribonucleotide biosynthetic process (GO:0009265)2.33915444
151deoxyribose phosphate biosynthetic process (GO:0046385)2.33915444
152regulation of ligase activity (GO:0051340)2.33567883
1537-methylguanosine mRNA capping (GO:0006370)2.33183223

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse4.62936498
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.08589093
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.90379804
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.84833310
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.68632351
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.37736840
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.36259552
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.34452403
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.26874578
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.88390200
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.87004197
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.78786722
13FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.64930186
14SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.63904354
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.54889173
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.51848936
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.50457761
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32993370
19VDR_23849224_ChIP-Seq_CD4+_Human2.32342092
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.31474626
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.31116155
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.28024992
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.26285851
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.26234049
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.16774699
26* SPI1_23547873_ChIP-Seq_NB4_Human2.16647988
27MYC_18555785_ChIP-Seq_MESCs_Mouse2.14377304
28STAT4_19710469_ChIP-ChIP_TH1__Mouse2.09799296
29IRF8_27001747_Chip-Seq_BMDM_Mouse2.05778429
30DCP1A_22483619_ChIP-Seq_HELA_Human2.03949917
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.99737357
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.97942922
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95139577
34ELK1_19687146_ChIP-ChIP_HELA_Human1.93353515
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.88842958
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.86977598
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.85260039
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.83751735
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.83380129
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.81216432
41* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.80045584
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.79208674
43CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.78934309
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.77420074
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.76959657
46NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73356702
47ERG_20887958_ChIP-Seq_HPC-7_Mouse1.72987712
48XRN2_22483619_ChIP-Seq_HELA_Human1.60280715
49FOXP3_21729870_ChIP-Seq_TREG_Human1.58935450
50GABP_19822575_ChIP-Seq_HepG2_Human1.58788531
51MYC_18940864_ChIP-ChIP_HL60_Human1.58544941
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58469362
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.56293406
54MYC_19030024_ChIP-ChIP_MESCs_Mouse1.50337764
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.49534223
56ELK1_22589737_ChIP-Seq_MCF10A_Human1.48317253
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47789985
58ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.43298009
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43101637
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42485104
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37955538
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36562384
63HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35966138
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34049748
65NELFA_20434984_ChIP-Seq_ESCs_Mouse1.30087403
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30049405
67GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.27441677
68TTF2_22483619_ChIP-Seq_HELA_Human1.26749709
69MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25524059
70EGR1_19374776_ChIP-ChIP_THP-1_Human1.25186886
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24776279
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.23587828
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22814277
74HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21061933
75E2F7_22180533_ChIP-Seq_HELA_Human1.21006504
76HTT_18923047_ChIP-ChIP_STHdh_Human1.19685742
77CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.19369350
78RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.18219715
79MYB_26560356_Chip-Seq_TH2_Human1.17777179
80TFEB_21752829_ChIP-Seq_HELA_Human1.17342590
81STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.16562501
82LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14416759
83FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13770038
84CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13201061
85PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12949299
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12916701
87CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11677073
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09717402
89SOX2_16153702_ChIP-ChIP_HESCs_Human1.09066337
90VDR_22108803_ChIP-Seq_LS180_Human1.08729907
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08193643
92RUNX1_22412390_ChIP-Seq_EML_Mouse1.08166266
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07751584
94FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.06656364
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06434200
96DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06249274
97PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.05777430
98MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05213371
99YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04644082
100CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03839081
101STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03456147
102VDR_24763502_ChIP-Seq_THP-1_Human1.03018469
103ERG_20517297_ChIP-Seq_VCAP_Human1.02574736
104CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01104094
105PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00306945
106SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98328243
107SPI1_23127762_ChIP-Seq_K562_Human0.97205045
108Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96174958
109GATA3_26560356_Chip-Seq_TH2_Human0.95323947
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94798948
111NANOG_16153702_ChIP-ChIP_HESCs_Human0.94432555
112EZH2_22144423_ChIP-Seq_EOC_Human0.93473673
113SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93228613
114KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93211127
115* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.92528221
116NANOG_18555785_ChIP-Seq_MESCs_Mouse0.92082415
117SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91752617
118SOX17_20123909_ChIP-Seq_XEN_Mouse0.91171256
119PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91152137
120SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90331346
121MAF_26560356_Chip-Seq_TH1_Human0.90175042
122PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.87888070
123POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87815820
124OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87654631
125ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86402285
126CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86292377
127SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85834942
128* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.85373278
129GATA2_22383799_ChIP-Seq_G1ME_Mouse0.85201810
130ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.85184564
131TP53_22573176_ChIP-Seq_HFKS_Human0.84343800
132POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.84183653
133VDR_21846776_ChIP-Seq_THP-1_Human0.84125830
134KDM5A_27292631_Chip-Seq_BREAST_Human0.83570165
135MYCN_18555785_ChIP-Seq_MESCs_Mouse0.82946865
136EWS_26573619_Chip-Seq_HEK293_Human0.82838686
137ZNF274_21170338_ChIP-Seq_K562_Hela0.82673690
138SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82229231
139AR_20517297_ChIP-Seq_VCAP_Human0.81941168
140FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.80810385
141NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.79565917
142CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.75925541
143ELF5_23300383_ChIP-Seq_T47D_Human0.75607682
144MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.72737099
145BMI1_23680149_ChIP-Seq_NPCS_Mouse0.72235615
146FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.72065439
147RBPJ_22232070_ChIP-Seq_NCS_Mouse0.71088836
148FOXA1_27270436_Chip-Seq_PROSTATE_Human0.69509112
149FOXA1_25329375_ChIP-Seq_VCAP_Human0.69509112

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.17206626
2MP0002148_abnormal_hypersensitivity_rea3.61912697
3MP0003011_delayed_dark_adaptation3.40612694
4MP0009785_altered_susceptibility_to3.38696629
5MP0005671_abnormal_response_to2.91358466
6MP0003436_decreased_susceptibility_to2.86376404
7MP0003806_abnormal_nucleotide_metabolis2.83804957
8MP0005000_abnormal_immune_tolerance2.74323472
9MP0005058_abnormal_lysosome_morphology2.67861974
10MP0002419_abnormal_innate_immunity2.47326570
11MP0000685_abnormal_immune_system2.42478927
12MP0005025_abnormal_response_to2.38212687
13MP0003136_yellow_coat_color2.33843332
14MP0004510_myositis2.33713450
15MP0002452_abnormal_antigen_presenting2.28578263
16MP0002938_white_spotting2.28181297
17MP0001819_abnormal_immune_cell2.23407356
18MP0009333_abnormal_splenocyte_physiolog2.22450960
19MP0002420_abnormal_adaptive_immunity2.21176056
20MP0002723_abnormal_immune_serum2.20502642
21MP0001790_abnormal_immune_system2.15967377
22MP0005387_immune_system_phenotype2.15967377
23MP0003724_increased_susceptibility_to2.14333436
24MP0001800_abnormal_humoral_immune2.06944921
25MP0006082_CNS_inflammation2.05715408
26MP0003880_abnormal_central_pattern1.99091880
27MP0002102_abnormal_ear_morphology1.94688308
28MP0002736_abnormal_nociception_after1.87095599
29MP0008789_abnormal_olfactory_epithelium1.86602558
30MP0002163_abnormal_gland_morphology1.85269077
31MP0002822_catalepsy1.84477973
32MP0010030_abnormal_orbit_morphology1.84441122
33MP0005408_hypopigmentation1.83008523
34MP0008260_abnormal_autophagy1.82097971
35MP0004142_abnormal_muscle_tone1.80620485
36MP0005310_abnormal_salivary_gland1.77985566
37MP0001968_abnormal_touch/_nociception1.76253799
38MP0003186_abnormal_redox_activity1.76226483
39MP0006276_abnormal_autonomic_nervous1.73988158
40MP0002398_abnormal_bone_marrow1.72359894
41MP0002653_abnormal_ependyma_morphology1.67958249
42MP0006035_abnormal_mitochondrial_morpho1.67556128
43MP0000716_abnormal_immune_system1.67278359
44MP0001533_abnormal_skeleton_physiology1.65337620
45MP0001853_heart_inflammation1.61160736
46MP0005464_abnormal_platelet_physiology1.59962017
47MP0002909_abnormal_adrenal_gland1.59891379
48MP0004859_abnormal_synaptic_plasticity1.57784832
49MP0006292_abnormal_olfactory_placode1.55415943
50MP0006072_abnormal_retinal_apoptosis1.53581439
51MP0003303_peritoneal_inflammation1.52085870
52MP0002006_tumorigenesis1.50554958
53MP0001905_abnormal_dopamine_level1.46586601
54MP0002876_abnormal_thyroid_physiology1.45808340
55MP0002405_respiratory_system_inflammati1.45655586
56MP0002429_abnormal_blood_cell1.42352589
57MP0000015_abnormal_ear_pigmentation1.39144702
58MP0000343_altered_response_to1.39112906
59MP0001845_abnormal_inflammatory_respons1.38584507
60MP0003122_maternal_imprinting1.35809556
61MP0008995_early_reproductive_senescence1.33881472
62MP0005646_abnormal_pituitary_gland1.33743725
63MP0002277_abnormal_respiratory_mucosa1.33463392
64MP0001984_abnormal_olfaction1.31403042
65MP0000689_abnormal_spleen_morphology1.31127218
66MP0002166_altered_tumor_susceptibility1.31075281
67MP0005499_abnormal_olfactory_system1.28935083
68MP0005394_taste/olfaction_phenotype1.28935083
69MP0003763_abnormal_thymus_physiology1.28135882
70MP0003075_altered_response_to1.26816381
71MP0002090_abnormal_vision1.26364294
72MP0003718_maternal_effect1.24905604
73MP0002722_abnormal_immune_system1.24547640
74MP0003638_abnormal_response/metabolism_1.21719874
75MP0002295_abnormal_pulmonary_circulatio1.20905125
76MP0008058_abnormal_DNA_repair1.20001451
77MP0000858_altered_metastatic_potential1.19050920
78MP0001756_abnormal_urination1.18472299
79MP0002751_abnormal_autonomic_nervous1.15583194
80MP0003938_abnormal_ear_development1.15169903
81MP0003183_abnormal_peptide_metabolism1.14008335
82MP0000516_abnormal_urinary_system1.13209588
83MP0005367_renal/urinary_system_phenotyp1.13209588
84MP0008469_abnormal_protein_level1.12996633
85MP0002064_seizures1.12470339
86MP0005397_hematopoietic_system_phenotyp1.12363417
87MP0001545_abnormal_hematopoietic_system1.12363417
88MP0005174_abnormal_tail_pigmentation1.10417467
89MP0008932_abnormal_embryonic_tissue1.10308952
90MP0010155_abnormal_intestine_physiology1.09501049
91MP0004147_increased_porphyrin_level1.09372684
92MP0002095_abnormal_skin_pigmentation1.08637411
93MP0003693_abnormal_embryo_hatching1.08468987
94MP0005410_abnormal_fertilization1.08463345
95MP0002735_abnormal_chemical_nociception1.08447719
96MP0001986_abnormal_taste_sensitivity1.06449957
97MP0003786_premature_aging1.03569773
98MP0005253_abnormal_eye_physiology1.03214121
99MP0005379_endocrine/exocrine_gland_phen1.03193959
100MP0004019_abnormal_vitamin_homeostasis1.02559749
101MP0001529_abnormal_vocalization1.01738903
102MP0009745_abnormal_behavioral_response0.99908871
103MP0009764_decreased_sensitivity_to0.96534765
104MP0003635_abnormal_synaptic_transmissio0.96295204
105MP0003448_altered_tumor_morphology0.95849843
106MP0001970_abnormal_pain_threshold0.94891348
107MP0004957_abnormal_blastocyst_morpholog0.94788190
108MP0000681_abnormal_thyroid_gland0.94639717
109MP0010386_abnormal_urinary_bladder0.94315950
110MP0005551_abnormal_eye_electrophysiolog0.93892502
111MP0002734_abnormal_mechanical_nocicepti0.93434472
112MP0003172_abnormal_lysosome_physiology0.93299388
113MP0002396_abnormal_hematopoietic_system0.93264733
114MP0003191_abnormal_cellular_cholesterol0.92792232
115MP0003866_abnormal_defecation0.91507055
116MP0009379_abnormal_foot_pigmentation0.88574380
117MP0002132_abnormal_respiratory_system0.88490979
118MP0008875_abnormal_xenobiotic_pharmacok0.88295353
119MP0003879_abnormal_hair_cell0.88142981
120MP0002557_abnormal_social/conspecific_i0.87525228
121MP0002063_abnormal_learning/memory/cond0.87187731
122MP0001542_abnormal_bone_strength0.87065726
123MP0006036_abnormal_mitochondrial_physio0.86596964
124MP0005171_absent_coat_pigmentation0.86416037
125MP0002638_abnormal_pupillary_reflex0.86055219
126MP0002733_abnormal_thermal_nociception0.85385743
127MP0004808_abnormal_hematopoietic_stem0.85256221
128MP0002933_joint_inflammation0.85080273
129MP0005332_abnormal_amino_acid0.85046631
130MP0002272_abnormal_nervous_system0.85028046
131MP0001293_anophthalmia0.84958644
132MP0005423_abnormal_somatic_nervous0.84606739
133MP0009697_abnormal_copulation0.84199514
134MP0000631_abnormal_neuroendocrine_gland0.83758503
135MP0001879_abnormal_lymphatic_vessel0.83392544
136MP0000026_abnormal_inner_ear0.83022550
137MP0008872_abnormal_physiological_respon0.82756140
138MP0000490_abnormal_crypts_of0.82424107
139MP0008007_abnormal_cellular_replicative0.82028424
140MP0002998_abnormal_bone_remodeling0.81938789
141MP0003283_abnormal_digestive_organ0.81336650
142MP0000358_abnormal_cell_content/0.80953622
143MP0005636_abnormal_mineral_homeostasis0.80890277
144MP0001348_abnormal_lacrimal_gland0.80476860
145MP0005075_abnormal_melanosome_morpholog0.79509932
146MP0005166_decreased_susceptibility_to0.79505155
147MP0008004_abnormal_stomach_pH0.79329595
148MP0004782_abnormal_surfactant_physiolog0.78706120
149MP0001501_abnormal_sleep_pattern0.78662257
150MP0000049_abnormal_middle_ear0.78475605
151MP0005164_abnormal_response_to0.77578528
152MP0000372_irregular_coat_pigmentation0.76687788
153MP0005645_abnormal_hypothalamus_physiol0.76423020
154MP0004947_skin_inflammation0.75777934
155MP0002837_dystrophic_cardiac_calcinosis0.75344151
156MP0000703_abnormal_thymus_morphology0.74574835
157MP0004133_heterotaxia0.72894999
158MP0009046_muscle_twitch0.72625997
159MP0001188_hyperpigmentation0.72226711
160MP0002572_abnormal_emotion/affect_behav0.72000847
161MP0008438_abnormal_cutaneous_collagen0.69962953
162MP0001485_abnormal_pinna_reflex0.69691242
163MP0002184_abnormal_innervation0.69370029
164MP0005084_abnormal_gallbladder_morpholo0.69220967
165MP0005503_abnormal_tendon_morphology0.69174022
166MP0004883_abnormal_blood_vessel0.69025456
167MP0005083_abnormal_biliary_tract0.68285176
168MP0001764_abnormal_homeostasis0.67986071
169MP0003315_abnormal_perineum_morphology0.63297702
170MP0002233_abnormal_nose_morphology0.62944479
171MP0002752_abnormal_somatic_nervous0.62245674
172MP0004742_abnormal_vestibular_system0.61523395
173MP0000647_abnormal_sebaceous_gland0.61491443
174MP0001324_abnormal_eye_pigmentation0.61385900

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.94668854
2Recurrent bacterial skin infections (HP:0005406)4.25187833
3Cerebral edema (HP:0002181)4.00008634
4Eczematoid dermatitis (HP:0000976)3.93213191
5Macrocytic anemia (HP:0001972)3.88560028
6Acute necrotizing encephalopathy (HP:0006965)3.82832456
7Hepatocellular necrosis (HP:0001404)3.77911278
8Mitochondrial inheritance (HP:0001427)3.73126991
9Abnormal mitochondria in muscle tissue (HP:0008316)3.70369669
10Abnormality of macrophages (HP:0004311)3.69918631
11Elevated erythrocyte sedimentation rate (HP:0003565)3.45670351
12Generalized aminoaciduria (HP:0002909)3.34671508
13Hepatic necrosis (HP:0002605)3.29448271
14Abnormality of renal resorption (HP:0011038)3.28845907
15Increased muscle lipid content (HP:0009058)3.28485718
16Vacuolated lymphocytes (HP:0001922)3.22859439
17Mediastinal lymphadenopathy (HP:0100721)3.22595096
18Increased CSF lactate (HP:0002490)3.21517480
19Increased IgM level (HP:0003496)3.19264504
20Agnosia (HP:0010524)3.11914173
21Progressive macrocephaly (HP:0004481)3.08908700
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.08713896
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.08713896
24Increased neuronal autofluorescent lipopigment (HP:0002074)3.07792252
25Abnormality of the anterior horn cell (HP:0006802)2.98155115
26Degeneration of anterior horn cells (HP:0002398)2.98155115
27Poor head control (HP:0002421)2.97817318
28Obstructive lung disease (HP:0006536)2.97390980
29Chronic obstructive pulmonary disease (HP:0006510)2.97390980
30Optic disc pallor (HP:0000543)2.91826766
31Leukodystrophy (HP:0002415)2.85514512
32Increased cerebral lipofuscin (HP:0011813)2.84246207
33Petechiae (HP:0000967)2.80758082
34Aplastic anemia (HP:0001915)2.78695877
35Myositis (HP:0100614)2.78572069
36Thrombocytosis (HP:0001894)2.77260343
37Acute encephalopathy (HP:0006846)2.76607650
38Type I transferrin isoform profile (HP:0003642)2.76422334
39Basal ganglia calcification (HP:0002135)2.67042301
40Focal motor seizures (HP:0011153)2.66483552
41Exertional dyspnea (HP:0002875)2.65167267
42Glycosuria (HP:0003076)2.65090460
43Abnormality of urine glucose concentration (HP:0011016)2.65090460
44Congenital, generalized hypertrichosis (HP:0004540)2.65040668
45Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.61519603
46Stomatitis (HP:0010280)2.61380365
47Neuroendocrine neoplasm (HP:0100634)2.59565089
48Recurrent skin infections (HP:0001581)2.58760812
49Abnormality of glycolipid metabolism (HP:0010969)2.57860756
50Abnormality of liposaccharide metabolism (HP:0010968)2.57860756
51Abnormality of glycosphingolipid metabolism (HP:0004343)2.57860756
52Recurrent fungal infections (HP:0002841)2.55536286
53Lethargy (HP:0001254)2.52930278
54Hyperphosphaturia (HP:0003109)2.51908597
55Recurrent gram-negative bacterial infections (HP:0005420)2.49305224
56Respiratory failure (HP:0002878)2.48807547
57Prolonged neonatal jaundice (HP:0006579)2.45480365
58Pallor (HP:0000980)2.41486838
59X-linked dominant inheritance (HP:0001423)2.40803183
60Increased hepatocellular lipid droplets (HP:0006565)2.40493541
61Abnormality of aromatic amino acid family metabolism (HP:0004338)2.37533749
62Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.32205113
63Hypergammaglobulinemia (HP:0010702)2.30322371
64Dysostosis multiplex (HP:0000943)2.27294572
65Medial flaring of the eyebrow (HP:0010747)2.25691781
66Increased serum lactate (HP:0002151)2.23712898
67Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.22914188
68Systemic lupus erythematosus (HP:0002725)2.22630346
69Chronic otitis media (HP:0000389)2.20853972
70Abnormal glycosylation (HP:0012345)2.20120474
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.20120474
72Abnormal protein N-linked glycosylation (HP:0012347)2.20120474
73Abnormal protein glycosylation (HP:0012346)2.20120474
74Recurrent viral infections (HP:0004429)2.19576354
75Autoimmune thrombocytopenia (HP:0001973)2.18098219
76Nausea (HP:0002018)2.17579204
77Meningitis (HP:0001287)2.17475072
78Retrobulbar optic neuritis (HP:0100654)2.17175285
79Optic neuritis (HP:0100653)2.17175285
80Abnormal number of erythroid precursors (HP:0012131)2.16202985
81IgG deficiency (HP:0004315)2.16166888
82Abnormality of cells of the erythroid lineage (HP:0012130)2.16007269
83Exercise intolerance (HP:0003546)2.15736482
84Vertebral compression fractures (HP:0002953)2.15366636
85Interstitial pulmonary disease (HP:0006530)2.14819502
86Hypothermia (HP:0002045)2.13564779
87Abnormal pupillary function (HP:0007686)2.13445552
88CNS demyelination (HP:0007305)2.12005867
89Orchitis (HP:0100796)2.11223404
90Polyphagia (HP:0002591)2.10017135
91Abnormality of placental membranes (HP:0011409)2.08965294
92Amniotic constriction ring (HP:0009775)2.08965294
93Pheochromocytoma (HP:0002666)2.08733106
94Birth length less than 3rd percentile (HP:0003561)2.06893134
95Abnormal hair whorl (HP:0010721)2.06109136
96Aplasia/Hypoplasia of the sacrum (HP:0008517)2.05657400
97Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.05636123
98Increased intramyocellular lipid droplets (HP:0012240)2.05338058
99Lactic acidosis (HP:0003128)2.04858132
100Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.04803525
101Renal Fanconi syndrome (HP:0001994)2.04338182
102Cellulitis (HP:0100658)2.04247087
103Vasculitis (HP:0002633)2.03774929
104Hypoglycemic coma (HP:0001325)2.02934340
105Reduced antithrombin III activity (HP:0001976)2.02142464
106Neutropenia (HP:0001875)2.01787686
107Gingivitis (HP:0000230)2.01477186
108Methylmalonic acidemia (HP:0002912)2.00695579
109Abnormal ciliary motility (HP:0012262)1.98702690
110Eosinophilia (HP:0001880)1.98580662
111Reticulocytopenia (HP:0001896)1.97181180
112Lipid accumulation in hepatocytes (HP:0006561)1.96695362
113IgM deficiency (HP:0002850)1.95892463
114Abnormal respiratory motile cilium physiology (HP:0012261)1.95151805
115Cerebral hypomyelination (HP:0006808)1.94703289
116Methylmalonic aciduria (HP:0012120)1.92677302
117Purpura (HP:0000979)1.92419846
118Myokymia (HP:0002411)1.91214959
119Hepatosplenomegaly (HP:0001433)1.88762532
120Recurrent pneumonia (HP:0006532)1.88692780
121Pulmonary infiltrates (HP:0002113)1.88361014
122Renal tubular dysfunction (HP:0000124)1.88300168
123Abnormality of dicarboxylic acid metabolism (HP:0010995)1.87817164
124Dicarboxylic aciduria (HP:0003215)1.87817164
125Pulmonary fibrosis (HP:0002206)1.87778230
126Congenital ichthyosiform erythroderma (HP:0007431)1.86213025
127Blindness (HP:0000618)1.86043201
128Increased serum pyruvate (HP:0003542)1.84048683
129Abnormality of glycolysis (HP:0004366)1.84048683
130Heterochromia iridis (HP:0001100)1.83893213
131Stenosis of the external auditory canal (HP:0000402)1.83430636
132Epileptic encephalopathy (HP:0200134)1.82281445
133Pancreatic fibrosis (HP:0100732)1.82037227
134Pancreatic cysts (HP:0001737)1.79374773
135Abnormal respiratory epithelium morphology (HP:0012253)1.79278087
136Abnormal respiratory motile cilium morphology (HP:0005938)1.79278087
137Poor suck (HP:0002033)1.78561140
138Respiratory difficulties (HP:0002880)1.77923204
139Gait imbalance (HP:0002141)1.77867180
140Cholecystitis (HP:0001082)1.77832632
141Abnormal gallbladder physiology (HP:0012438)1.77832632
142Congenital primary aphakia (HP:0007707)1.77828756
143True hermaphroditism (HP:0010459)1.77804273
1443-Methylglutaconic aciduria (HP:0003535)1.77595867
145Granulocytopenia (HP:0001913)1.76807759
146Emotional lability (HP:0000712)1.76291319
147Abnormal urine phosphate concentration (HP:0012599)1.75922658
148Abnormality of methionine metabolism (HP:0010901)1.70418545
149Limb dystonia (HP:0002451)1.69351480
150Oral leukoplakia (HP:0002745)1.67791905
151Concave nail (HP:0001598)1.62045604
152Microvesicular hepatic steatosis (HP:0001414)1.61880680
153Abnormal hemoglobin (HP:0011902)1.60931479
154Nephrogenic diabetes insipidus (HP:0009806)1.59236301
155Abnormality of aspartate family amino acid metabolism (HP:0010899)1.59052977
156Vomiting (HP:0002013)1.58338499
157Retinal dysplasia (HP:0007973)1.57679997
158Septo-optic dysplasia (HP:0100842)1.56890886

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.59819484
2MAP3K124.10128924
3RIPK43.92216870
4ARAF3.39587016
5NME23.18244468
6PIM22.54970159
7MAP3K142.37269448
8STK162.20902387
9CDK192.08459196
10BMPR22.04629023
11BLK2.01003291
12DAPK11.92492400
13DYRK21.90570810
14PRPF4B1.85795551
15TRIM281.83340787
16BUB11.82357507
17BCKDK1.81490740
18EIF2AK11.75177320
19TESK21.74374268
20MST41.72813309
21MAP2K71.70595063
22EIF2AK31.70586760
23MYLK1.66476498
24TESK11.64994216
25EPHB21.64848955
26NME11.61293660
27SIK31.60392424
28TBK11.59893720
29BRAF1.59235670
30KIT1.50631712
31SYK1.50330246
32TXK1.50076469
33ZAK1.48774056
34MAP3K131.45749439
35TSSK61.43044853
36MAP4K11.40897218
37IKBKB1.39853953
38IRAK41.38359295
39SCYL21.37366086
40CASK1.36489595
41ZAP701.36177336
42LRRK21.35446286
43CCNB11.32107115
44WNK31.31651067
45TYK21.28360655
46PBK1.26184304
47RAF11.24758240
48JAK31.23938930
49PLK31.22209404
50PDK21.20409612
51PLK21.19424650
52PASK1.15151061
53CAMKK21.12538026
54WEE11.09021881
55VRK11.06660466
56ADRBK21.06339167
57CSNK1G31.06111584
58ACVR1B1.04955574
59ABL21.03763991
60GRK10.99988925
61IKBKE0.97095064
62EPHA40.96584168
63DYRK30.96473154
64KSR20.95496561
65PAK30.94311381
66TLK10.93356248
67BCR0.93083554
68DAPK30.92543048
69ILK0.91933908
70CSNK1G20.91558719
71INSRR0.90557145
72MAP4K20.89792910
73KDR0.85595073
74LIMK10.82940329
75DAPK20.82589407
76MAPK150.81258941
77MAP3K110.81034082
78TIE10.79206844
79LYN0.78568964
80MINK10.77615927
81CSNK1G10.75564379
82PINK10.73871127
83FES0.73325826
84GRK60.71229783
85TEC0.70888525
86MARK10.69877931
87BMPR1B0.69855268
88NEK90.68380546
89BTK0.67298434
90PRKCD0.67237645
91IRAK30.66775754
92ADRBK10.66739766
93PNCK0.63037457
94CSNK2A20.63002323
95MAP2K30.62192884
96CSNK1A1L0.60767038
97MOS0.60267018
98GRK70.59884792
99TGFBR10.59873001
100GRK50.59710850
101CSF1R0.59160763
102CSNK2A10.57388373
103NUAK10.57080084
104TAF10.56792211
105MAPKAPK30.55549463
106NTRK30.54769049
107STK240.53949809
108AURKA0.51981462
109PRKCE0.51180501
110LCK0.51071621
111PTK2B0.50956517
112CLK10.48909926
113CAMK2G0.47622409
114MAP3K90.46757375
115CDC70.45808080
116KSR10.43625067
117PAK10.42348619
118PLK10.41573560
119CDK140.41318933
120PIM10.41048826
121JAK10.40838489
122PAK40.40103830
123PAK20.39697613
124CAMK2D0.39586812
125CDK180.38853479
126ROCK20.38034911
127BRSK10.37777871
128MAP3K40.37161122
129PRKCG0.36710063
130EIF2AK20.36587899
131OXSR10.36193515
132RPS6KA50.35837993
133CDK80.35743359
134PHKG20.35194755
135PHKG10.35194755
136PLK40.35150917
137MUSK0.34789012
138MAPKAPK20.34261096
139NEK10.32886871
140CAMK2A0.32644498
141MAP3K10.31113143
142TNIK0.30564180
143CHUK0.29980121
144CDK150.29267172
145RPS6KA40.28816231
146SRPK10.28594060
147CDK11A0.27348610

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.43640978
2Oxidative phosphorylation_Homo sapiens_hsa001902.82276095
3Ribosome_Homo sapiens_hsa030102.54649565
4Collecting duct acid secretion_Homo sapiens_hsa049662.43007536
5Parkinsons disease_Homo sapiens_hsa050122.33413154
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.25295153
7Protein export_Homo sapiens_hsa030602.16902871
8Fatty acid elongation_Homo sapiens_hsa000622.13488551
9Graft-versus-host disease_Homo sapiens_hsa053322.05329603
10RNA polymerase_Homo sapiens_hsa030202.02964179
11Rheumatoid arthritis_Homo sapiens_hsa053232.01492643
12Allograft rejection_Homo sapiens_hsa053302.00389554
13Vibrio cholerae infection_Homo sapiens_hsa051101.93560524
14Synaptic vesicle cycle_Homo sapiens_hsa047211.76085788
15Leishmaniasis_Homo sapiens_hsa051401.73258771
16Type I diabetes mellitus_Homo sapiens_hsa049401.70759720
17DNA replication_Homo sapiens_hsa030301.70030893
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.69289438
19Alzheimers disease_Homo sapiens_hsa050101.67782158
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65051612
21Shigellosis_Homo sapiens_hsa051311.62412231
22Legionellosis_Homo sapiens_hsa051341.62034469
23Huntingtons disease_Homo sapiens_hsa050161.58213303
24Glutathione metabolism_Homo sapiens_hsa004801.55932494
25Phagosome_Homo sapiens_hsa041451.53548829
26Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.47931824
27Sulfur metabolism_Homo sapiens_hsa009201.46185527
28Folate biosynthesis_Homo sapiens_hsa007901.46132588
29Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.40908273
30Lysosome_Homo sapiens_hsa041421.39179350
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.37749200
32Pertussis_Homo sapiens_hsa051331.35979919
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.31861820
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.30639101
35Tuberculosis_Homo sapiens_hsa051521.29709817
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.26961261
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25565463
38Pyrimidine metabolism_Homo sapiens_hsa002401.25263740
39Salmonella infection_Homo sapiens_hsa051321.24590210
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22798098
41Antigen processing and presentation_Homo sapiens_hsa046121.20367437
42Other glycan degradation_Homo sapiens_hsa005111.18411735
43Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16170467
44Mismatch repair_Homo sapiens_hsa034301.16170338
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09867636
46Primary immunodeficiency_Homo sapiens_hsa053401.09591582
47Regulation of autophagy_Homo sapiens_hsa041401.09449785
48Nucleotide excision repair_Homo sapiens_hsa034201.05513182
49Propanoate metabolism_Homo sapiens_hsa006401.05406146
50Asthma_Homo sapiens_hsa053101.04436816
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03452041
52Base excision repair_Homo sapiens_hsa034101.03170519
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02470170
54Autoimmune thyroid disease_Homo sapiens_hsa053201.01542389
55Butanoate metabolism_Homo sapiens_hsa006501.00935865
56Measles_Homo sapiens_hsa051620.97720963
57Osteoclast differentiation_Homo sapiens_hsa043800.96752443
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96650090
59Epstein-Barr virus infection_Homo sapiens_hsa051690.95788308
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.94896072
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94015354
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93889512
63Peroxisome_Homo sapiens_hsa041460.93397851
64Pyruvate metabolism_Homo sapiens_hsa006200.91818825
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91811226
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.88081210
67Sulfur relay system_Homo sapiens_hsa041220.88016052
68Metabolic pathways_Homo sapiens_hsa011000.85229268
69Homologous recombination_Homo sapiens_hsa034400.84592039
70B cell receptor signaling pathway_Homo sapiens_hsa046620.83499686
71Chemokine signaling pathway_Homo sapiens_hsa040620.80246499
72Steroid biosynthesis_Homo sapiens_hsa001000.78417174
73African trypanosomiasis_Homo sapiens_hsa051430.77469895
74Apoptosis_Homo sapiens_hsa042100.76581846
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76217710
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75909555
77Influenza A_Homo sapiens_hsa051640.75822861
78Purine metabolism_Homo sapiens_hsa002300.75355100
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.75335583
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75184297
81Carbon metabolism_Homo sapiens_hsa012000.74998339
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74321532
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73043899
84Herpes simplex infection_Homo sapiens_hsa051680.71482953
85Hematopoietic cell lineage_Homo sapiens_hsa046400.70453109
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70053023
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69631884
88Olfactory transduction_Homo sapiens_hsa047400.69595646
89Long-term potentiation_Homo sapiens_hsa047200.68192870
90TNF signaling pathway_Homo sapiens_hsa046680.66498836
91Malaria_Homo sapiens_hsa051440.66479296
92One carbon pool by folate_Homo sapiens_hsa006700.63942387
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63538364
94RNA degradation_Homo sapiens_hsa030180.63527459
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62494656
96Spliceosome_Homo sapiens_hsa030400.61988245
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.59291134
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58561375
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58396870
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58261200
101Chemical carcinogenesis_Homo sapiens_hsa052040.57732504
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57583573
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57556539
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.56275003
105Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56212143
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56049731
107Hepatitis B_Homo sapiens_hsa051610.55133956
108Tyrosine metabolism_Homo sapiens_hsa003500.53762725
109beta-Alanine metabolism_Homo sapiens_hsa004100.53126571
110Toxoplasmosis_Homo sapiens_hsa051450.52948622
111Phototransduction_Homo sapiens_hsa047440.52746479
112Morphine addiction_Homo sapiens_hsa050320.52306827
113Biosynthesis of amino acids_Homo sapiens_hsa012300.51262499
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50196770
115Cardiac muscle contraction_Homo sapiens_hsa042600.48037524
116Nicotine addiction_Homo sapiens_hsa050330.47596101
117Amphetamine addiction_Homo sapiens_hsa050310.47341739
118Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46893198
119Nitrogen metabolism_Homo sapiens_hsa009100.45831009
120Viral myocarditis_Homo sapiens_hsa054160.45824771
121Tryptophan metabolism_Homo sapiens_hsa003800.45799481
122Basal transcription factors_Homo sapiens_hsa030220.44617212
123Cysteine and methionine metabolism_Homo sapiens_hsa002700.44474979
124Serotonergic synapse_Homo sapiens_hsa047260.44223508
125T cell receptor signaling pathway_Homo sapiens_hsa046600.40137301
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.38746553
127Arachidonic acid metabolism_Homo sapiens_hsa005900.36888349
128Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36871888
129Pentose phosphate pathway_Homo sapiens_hsa000300.35555688
130Dopaminergic synapse_Homo sapiens_hsa047280.35527300
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.35375278
132Circadian entrainment_Homo sapiens_hsa047130.35332015
133Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34053767
134Fatty acid metabolism_Homo sapiens_hsa012120.33657443
135Fructose and mannose metabolism_Homo sapiens_hsa000510.33378268
136RNA transport_Homo sapiens_hsa030130.33359755
137Galactose metabolism_Homo sapiens_hsa000520.32929794
138Endocytosis_Homo sapiens_hsa041440.32874456
139Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32618808
140Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31874226
141Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31564860
142Fatty acid degradation_Homo sapiens_hsa000710.31385179
143GABAergic synapse_Homo sapiens_hsa047270.31232918
144Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.31128746
145Mineral absorption_Homo sapiens_hsa049780.30627412
146N-Glycan biosynthesis_Homo sapiens_hsa005100.30562373
147Arginine and proline metabolism_Homo sapiens_hsa003300.29671731
148Fat digestion and absorption_Homo sapiens_hsa049750.29367324
149p53 signaling pathway_Homo sapiens_hsa041150.26458111
150Drug metabolism - other enzymes_Homo sapiens_hsa009830.22367676
151Fanconi anemia pathway_Homo sapiens_hsa034600.21871355
152Retinol metabolism_Homo sapiens_hsa008300.21865254
153Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.18894145
154Selenocompound metabolism_Homo sapiens_hsa004500.18817731
155Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18361063
156Phenylalanine metabolism_Homo sapiens_hsa003600.17155629
157Vitamin B6 metabolism_Homo sapiens_hsa007500.12845144

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