

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | viral transcription (GO:0019083) | 6.49486541 |
| 2 | translational termination (GO:0006415) | 6.24563383 |
| 3 | protein targeting to ER (GO:0045047) | 6.11307622 |
| 4 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 5.88409318 |
| 5 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.88138011 |
| 6 | protein localization to endoplasmic reticulum (GO:0070972) | 5.85174927 |
| 7 | translational elongation (GO:0006414) | 5.34531521 |
| 8 | viral life cycle (GO:0019058) | 5.02830499 |
| 9 | cellular protein complex disassembly (GO:0043624) | 4.86862611 |
| 10 | ribosomal small subunit biogenesis (GO:0042274) | 4.66957134 |
| 11 | translational initiation (GO:0006413) | 4.60592393 |
| 12 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.59888088 |
| 13 | hydrogen ion transmembrane transport (GO:1902600) | 4.50101140 |
| 14 | ribosomal large subunit biogenesis (GO:0042273) | 4.49821992 |
| 15 | ATP biosynthetic process (GO:0006754) | 4.44930952 |
| 16 | neutrophil activation involved in immune response (GO:0002283) | 4.42134350 |
| 17 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.35635137 |
| 18 | translation (GO:0006412) | 4.29520885 |
| 19 | protein targeting to membrane (GO:0006612) | 4.17311262 |
| 20 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.17076716 |
| 21 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.17076716 |
| 22 | NADH dehydrogenase complex assembly (GO:0010257) | 4.17076716 |
| 23 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 4.13195833 |
| 24 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 4.12788408 |
| 25 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 4.11707651 |
| 26 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 4.09165608 |
| 27 | maturation of SSU-rRNA (GO:0030490) | 4.08481763 |
| 28 | protein complex disassembly (GO:0043241) | 4.07976264 |
| 29 | ribosomal small subunit assembly (GO:0000028) | 4.06172832 |
| 30 | proton transport (GO:0015992) | 4.01629817 |
| 31 | hydrogen transport (GO:0006818) | 3.93627313 |
| 32 | macromolecular complex disassembly (GO:0032984) | 3.91777454 |
| 33 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.84628099 |
| 34 | regulation of mitochondrial translation (GO:0070129) | 3.73920046 |
| 35 | oxidative phosphorylation (GO:0006119) | 3.73117797 |
| 36 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.66429603 |
| 37 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.64227283 |
| 38 | platelet dense granule organization (GO:0060155) | 3.61578409 |
| 39 | protein localization to mitochondrion (GO:0070585) | 3.56999703 |
| 40 | rRNA modification (GO:0000154) | 3.50410340 |
| 41 | cullin deneddylation (GO:0010388) | 3.48956970 |
| 42 | phagosome maturation (GO:0090382) | 3.46469049 |
| 43 | protein deneddylation (GO:0000338) | 3.45905390 |
| 44 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.44665932 |
| 45 | inner mitochondrial membrane organization (GO:0007007) | 3.43792115 |
| 46 | nucleoside triphosphate biosynthetic process (GO:0009142) | 3.41587646 |
| 47 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.38300659 |
| 48 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.37156948 |
| 49 | sequestering of actin monomers (GO:0042989) | 3.35249589 |
| 50 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 3.32679919 |
| 51 | respiratory burst (GO:0045730) | 3.31905899 |
| 52 | proteasome assembly (GO:0043248) | 3.30253703 |
| 53 | mitochondrial transport (GO:0006839) | 3.29114292 |
| 54 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.28511082 |
| 55 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.28511082 |
| 56 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 3.28080037 |
| 57 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.25573372 |
| 58 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.25573372 |
| 59 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.25573372 |
| 60 | DNA deamination (GO:0045006) | 3.24865440 |
| 61 | negative regulation of ligase activity (GO:0051352) | 3.24820327 |
| 62 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.24820327 |
| 63 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.21248571 |
| 64 | protein neddylation (GO:0045116) | 3.19402772 |
| 65 | establishment of protein localization to membrane (GO:0090150) | 3.18078761 |
| 66 | cytochrome complex assembly (GO:0017004) | 3.16961705 |
| 67 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.15764487 |
| 68 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.14012045 |
| 69 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.14012045 |
| 70 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.13806233 |
| 71 | GTP biosynthetic process (GO:0006183) | 3.12701289 |
| 72 | aldehyde catabolic process (GO:0046185) | 3.11509578 |
| 73 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.11378478 |
| 74 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.11378478 |
| 75 | signal peptide processing (GO:0006465) | 3.11348473 |
| 76 | cellular component biogenesis (GO:0044085) | 3.11348330 |
| 77 | regulation of T-helper 1 cell differentiation (GO:0045625) | 3.08088204 |
| 78 | purine nucleoside monophosphate biosynthetic process (GO:0009127) | 3.07487194 |
| 79 | purine ribonucleoside monophosphate biosynthetic process (GO:0009168) | 3.07487194 |
| 80 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.06701134 |
| 81 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.04853025 |
| 82 | protein targeting (GO:0006605) | 3.04643639 |
| 83 | intracellular protein transmembrane import (GO:0044743) | 3.02528946 |
| 84 | aerobic respiration (GO:0009060) | 3.02147959 |
| 85 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.01059141 |
| 86 | ATP synthesis coupled proton transport (GO:0015986) | 2.98459965 |
| 87 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 2.98459965 |
| 88 | establishment of integrated proviral latency (GO:0075713) | 2.97885182 |
| 89 | transferrin transport (GO:0033572) | 2.97392691 |
| 90 | mRNA catabolic process (GO:0006402) | 2.95533657 |
| 91 | mast cell activation (GO:0045576) | 2.94037364 |
| 92 | actin nucleation (GO:0045010) | 2.93781904 |
| 93 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.93021055 |
| 94 | cellular response to interferon-beta (GO:0035458) | 2.91245494 |
| 95 | neutrophil activation (GO:0042119) | 2.90353285 |
| 96 | guanosine-containing compound biosynthetic process (GO:1901070) | 2.89960832 |
| 97 | regulation of oxidative phosphorylation (GO:0002082) | 2.89489145 |
| 98 | cellular response to zinc ion (GO:0071294) | 2.87916867 |
| 99 | negative regulation of myeloid cell apoptotic process (GO:0033033) | 2.86337257 |
| 100 | eosinophil chemotaxis (GO:0048245) | 2.85505527 |
| 101 | immunoglobulin mediated immune response (GO:0016064) | 2.84464828 |
| 102 | negative regulation of interleukin-17 production (GO:0032700) | 2.84447267 |
| 103 | granulocyte activation (GO:0036230) | 2.83761490 |
| 104 | ATP hydrolysis coupled proton transport (GO:0015991) | 2.82179689 |
| 105 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 2.82179689 |
| 106 | respiratory chain complex IV assembly (GO:0008535) | 2.81675773 |
| 107 | positive regulation of ligase activity (GO:0051351) | 2.81589759 |
| 108 | response to peptidoglycan (GO:0032494) | 2.73007298 |
| 109 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.71137931 |
| 110 | termination of RNA polymerase III transcription (GO:0006386) | 2.71137931 |
| 111 | response to interferon-beta (GO:0035456) | 2.66214379 |
| 112 | leukocyte degranulation (GO:0043299) | 2.65456150 |
| 113 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 2.63747458 |
| 114 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.63273412 |
| 115 | protein complex biogenesis (GO:0070271) | 2.62051595 |
| 116 | myeloid cell activation involved in immune response (GO:0002275) | 2.62001803 |
| 117 | chaperone-mediated protein transport (GO:0072321) | 2.61212474 |
| 118 | trivalent inorganic cation transport (GO:0072512) | 2.60003119 |
| 119 | ferric iron transport (GO:0015682) | 2.60003119 |
| 120 | regulation of cellular amine metabolic process (GO:0033238) | 2.58303662 |
| 121 | positive regulation of cell cycle arrest (GO:0071158) | 2.58053830 |
| 122 | myeloid dendritic cell activation (GO:0001773) | 2.56892473 |
| 123 | positive regulation of antigen processing and presentation (GO:0002579) | 2.56436062 |
| 124 | endosome to melanosome transport (GO:0035646) | 2.55091170 |
| 125 | endosome to pigment granule transport (GO:0043485) | 2.55091170 |
| 126 | nucleobase-containing small molecule interconversion (GO:0015949) | 2.54961185 |
| 127 | protein maturation by protein folding (GO:0022417) | 2.54476973 |
| 128 | eosinophil migration (GO:0072677) | 2.52062661 |
| 129 | NIK/NF-kappaB signaling (GO:0038061) | 2.51698061 |
| 130 | leukocyte mediated cytotoxicity (GO:0001909) | 2.51321243 |
| 131 | positive regulation of mitochondrial fission (GO:0090141) | 2.51248676 |
| 132 | myeloid dendritic cell differentiation (GO:0043011) | 2.49113222 |
| 133 | negative regulation of inflammatory response to antigenic stimulus (GO:0002862) | 2.48507382 |
| 134 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.47783001 |
| 135 | respiratory electron transport chain (GO:0022904) | 2.47018791 |
| 136 | B cell mediated immunity (GO:0019724) | 2.45846117 |
| 137 | protein targeting to mitochondrion (GO:0006626) | 2.45271347 |
| 138 | electron transport chain (GO:0022900) | 2.41766393 |
| 139 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.41124353 |
| 140 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.40810960 |
| 141 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 2.36978003 |
| 142 | positive regulation of monocyte chemotaxis (GO:0090026) | 2.36768671 |
| 143 | mast cell activation involved in immune response (GO:0002279) | 2.35393482 |
| 144 | mast cell degranulation (GO:0043303) | 2.35393482 |
| 145 | interferon-gamma-mediated signaling pathway (GO:0060333) | 2.34658990 |
| 146 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 2.34497190 |
| 147 | cotranslational protein targeting to membrane (GO:0006613) | 2.34325580 |
| 148 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 2.34104294 |
| 149 | establishment of protein localization to mitochondrion (GO:0072655) | 2.34021750 |
| 150 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 2.33915444 |
| 151 | deoxyribose phosphate biosynthetic process (GO:0046385) | 2.33915444 |
| 152 | regulation of ligase activity (GO:0051340) | 2.33567883 |
| 153 | 7-methylguanosine mRNA capping (GO:0006370) | 2.33183223 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 4.62936498 |
| 2 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 4.08589093 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.90379804 |
| 4 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.84833310 |
| 5 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.68632351 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.37736840 |
| 7 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.36259552 |
| 8 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.34452403 |
| 9 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.26874578 |
| 10 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.88390200 |
| 11 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.87004197 |
| 12 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.78786722 |
| 13 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 2.64930186 |
| 14 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.63904354 |
| 15 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.54889173 |
| 16 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.51848936 |
| 17 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.50457761 |
| 18 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.32993370 |
| 19 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.32342092 |
| 20 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.31474626 |
| 21 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.31116155 |
| 22 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.28024992 |
| 23 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.26285851 |
| 24 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.26234049 |
| 25 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.16774699 |
| 26 | * SPI1_23547873_ChIP-Seq_NB4_Human | 2.16647988 |
| 27 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.14377304 |
| 28 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.09799296 |
| 29 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.05778429 |
| 30 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.03949917 |
| 31 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.99737357 |
| 32 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.97942922 |
| 33 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.95139577 |
| 34 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.93353515 |
| 35 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.88842958 |
| 36 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.86977598 |
| 37 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.85260039 |
| 38 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.83751735 |
| 39 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.83380129 |
| 40 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.81216432 |
| 41 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.80045584 |
| 42 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.79208674 |
| 43 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.78934309 |
| 44 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.77420074 |
| 45 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.76959657 |
| 46 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.73356702 |
| 47 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.72987712 |
| 48 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.60280715 |
| 49 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.58935450 |
| 50 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.58788531 |
| 51 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.58544941 |
| 52 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.58469362 |
| 53 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.56293406 |
| 54 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.50337764 |
| 55 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.49534223 |
| 56 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.48317253 |
| 57 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.47789985 |
| 58 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.43298009 |
| 59 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.43101637 |
| 60 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.42485104 |
| 61 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.37955538 |
| 62 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.36562384 |
| 63 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.35966138 |
| 64 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.34049748 |
| 65 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.30087403 |
| 66 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.30049405 |
| 67 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.27441677 |
| 68 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.26749709 |
| 69 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.25524059 |
| 70 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.25186886 |
| 71 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.24776279 |
| 72 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.23587828 |
| 73 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.22814277 |
| 74 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.21061933 |
| 75 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.21006504 |
| 76 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.19685742 |
| 77 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.19369350 |
| 78 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.18219715 |
| 79 | MYB_26560356_Chip-Seq_TH2_Human | 1.17777179 |
| 80 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.17342590 |
| 81 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.16562501 |
| 82 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.14416759 |
| 83 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.13770038 |
| 84 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.13201061 |
| 85 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.12949299 |
| 86 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.12916701 |
| 87 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.11677073 |
| 88 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.09717402 |
| 89 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.09066337 |
| 90 | VDR_22108803_ChIP-Seq_LS180_Human | 1.08729907 |
| 91 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.08193643 |
| 92 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.08166266 |
| 93 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.07751584 |
| 94 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.06656364 |
| 95 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.06434200 |
| 96 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.06249274 |
| 97 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.05777430 |
| 98 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.05213371 |
| 99 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.04644082 |
| 100 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.03839081 |
| 101 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.03456147 |
| 102 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.03018469 |
| 103 | ERG_20517297_ChIP-Seq_VCAP_Human | 1.02574736 |
| 104 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.01104094 |
| 105 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.00306945 |
| 106 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.98328243 |
| 107 | SPI1_23127762_ChIP-Seq_K562_Human | 0.97205045 |
| 108 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.96174958 |
| 109 | GATA3_26560356_Chip-Seq_TH2_Human | 0.95323947 |
| 110 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.94798948 |
| 111 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.94432555 |
| 112 | EZH2_22144423_ChIP-Seq_EOC_Human | 0.93473673 |
| 113 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.93228613 |
| 114 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.93211127 |
| 115 | * EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.92528221 |
| 116 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.92082415 |
| 117 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.91752617 |
| 118 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.91171256 |
| 119 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.91152137 |
| 120 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.90331346 |
| 121 | MAF_26560356_Chip-Seq_TH1_Human | 0.90175042 |
| 122 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.87888070 |
| 123 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.87815820 |
| 124 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.87654631 |
| 125 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.86402285 |
| 126 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.86292377 |
| 127 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.85834942 |
| 128 | * RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.85373278 |
| 129 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 0.85201810 |
| 130 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.85184564 |
| 131 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.84343800 |
| 132 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.84183653 |
| 133 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.84125830 |
| 134 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.83570165 |
| 135 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.82946865 |
| 136 | EWS_26573619_Chip-Seq_HEK293_Human | 0.82838686 |
| 137 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.82673690 |
| 138 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.82229231 |
| 139 | AR_20517297_ChIP-Seq_VCAP_Human | 0.81941168 |
| 140 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 0.80810385 |
| 141 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.79565917 |
| 142 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.75925541 |
| 143 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.75607682 |
| 144 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.72737099 |
| 145 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.72235615 |
| 146 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.72065439 |
| 147 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.71088836 |
| 148 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.69509112 |
| 149 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.69509112 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001835_abnormal_antigen_presentation | 4.17206626 |
| 2 | MP0002148_abnormal_hypersensitivity_rea | 3.61912697 |
| 3 | MP0003011_delayed_dark_adaptation | 3.40612694 |
| 4 | MP0009785_altered_susceptibility_to | 3.38696629 |
| 5 | MP0005671_abnormal_response_to | 2.91358466 |
| 6 | MP0003436_decreased_susceptibility_to | 2.86376404 |
| 7 | MP0003806_abnormal_nucleotide_metabolis | 2.83804957 |
| 8 | MP0005000_abnormal_immune_tolerance | 2.74323472 |
| 9 | MP0005058_abnormal_lysosome_morphology | 2.67861974 |
| 10 | MP0002419_abnormal_innate_immunity | 2.47326570 |
| 11 | MP0000685_abnormal_immune_system | 2.42478927 |
| 12 | MP0005025_abnormal_response_to | 2.38212687 |
| 13 | MP0003136_yellow_coat_color | 2.33843332 |
| 14 | MP0004510_myositis | 2.33713450 |
| 15 | MP0002452_abnormal_antigen_presenting | 2.28578263 |
| 16 | MP0002938_white_spotting | 2.28181297 |
| 17 | MP0001819_abnormal_immune_cell | 2.23407356 |
| 18 | MP0009333_abnormal_splenocyte_physiolog | 2.22450960 |
| 19 | MP0002420_abnormal_adaptive_immunity | 2.21176056 |
| 20 | MP0002723_abnormal_immune_serum | 2.20502642 |
| 21 | MP0001790_abnormal_immune_system | 2.15967377 |
| 22 | MP0005387_immune_system_phenotype | 2.15967377 |
| 23 | MP0003724_increased_susceptibility_to | 2.14333436 |
| 24 | MP0001800_abnormal_humoral_immune | 2.06944921 |
| 25 | MP0006082_CNS_inflammation | 2.05715408 |
| 26 | MP0003880_abnormal_central_pattern | 1.99091880 |
| 27 | MP0002102_abnormal_ear_morphology | 1.94688308 |
| 28 | MP0002736_abnormal_nociception_after | 1.87095599 |
| 29 | MP0008789_abnormal_olfactory_epithelium | 1.86602558 |
| 30 | MP0002163_abnormal_gland_morphology | 1.85269077 |
| 31 | MP0002822_catalepsy | 1.84477973 |
| 32 | MP0010030_abnormal_orbit_morphology | 1.84441122 |
| 33 | MP0005408_hypopigmentation | 1.83008523 |
| 34 | MP0008260_abnormal_autophagy | 1.82097971 |
| 35 | MP0004142_abnormal_muscle_tone | 1.80620485 |
| 36 | MP0005310_abnormal_salivary_gland | 1.77985566 |
| 37 | MP0001968_abnormal_touch/_nociception | 1.76253799 |
| 38 | MP0003186_abnormal_redox_activity | 1.76226483 |
| 39 | MP0006276_abnormal_autonomic_nervous | 1.73988158 |
| 40 | MP0002398_abnormal_bone_marrow | 1.72359894 |
| 41 | MP0002653_abnormal_ependyma_morphology | 1.67958249 |
| 42 | MP0006035_abnormal_mitochondrial_morpho | 1.67556128 |
| 43 | MP0000716_abnormal_immune_system | 1.67278359 |
| 44 | MP0001533_abnormal_skeleton_physiology | 1.65337620 |
| 45 | MP0001853_heart_inflammation | 1.61160736 |
| 46 | MP0005464_abnormal_platelet_physiology | 1.59962017 |
| 47 | MP0002909_abnormal_adrenal_gland | 1.59891379 |
| 48 | MP0004859_abnormal_synaptic_plasticity | 1.57784832 |
| 49 | MP0006292_abnormal_olfactory_placode | 1.55415943 |
| 50 | MP0006072_abnormal_retinal_apoptosis | 1.53581439 |
| 51 | MP0003303_peritoneal_inflammation | 1.52085870 |
| 52 | MP0002006_tumorigenesis | 1.50554958 |
| 53 | MP0001905_abnormal_dopamine_level | 1.46586601 |
| 54 | MP0002876_abnormal_thyroid_physiology | 1.45808340 |
| 55 | MP0002405_respiratory_system_inflammati | 1.45655586 |
| 56 | MP0002429_abnormal_blood_cell | 1.42352589 |
| 57 | MP0000015_abnormal_ear_pigmentation | 1.39144702 |
| 58 | MP0000343_altered_response_to | 1.39112906 |
| 59 | MP0001845_abnormal_inflammatory_respons | 1.38584507 |
| 60 | MP0003122_maternal_imprinting | 1.35809556 |
| 61 | MP0008995_early_reproductive_senescence | 1.33881472 |
| 62 | MP0005646_abnormal_pituitary_gland | 1.33743725 |
| 63 | MP0002277_abnormal_respiratory_mucosa | 1.33463392 |
| 64 | MP0001984_abnormal_olfaction | 1.31403042 |
| 65 | MP0000689_abnormal_spleen_morphology | 1.31127218 |
| 66 | MP0002166_altered_tumor_susceptibility | 1.31075281 |
| 67 | MP0005499_abnormal_olfactory_system | 1.28935083 |
| 68 | MP0005394_taste/olfaction_phenotype | 1.28935083 |
| 69 | MP0003763_abnormal_thymus_physiology | 1.28135882 |
| 70 | MP0003075_altered_response_to | 1.26816381 |
| 71 | MP0002090_abnormal_vision | 1.26364294 |
| 72 | MP0003718_maternal_effect | 1.24905604 |
| 73 | MP0002722_abnormal_immune_system | 1.24547640 |
| 74 | MP0003638_abnormal_response/metabolism_ | 1.21719874 |
| 75 | MP0002295_abnormal_pulmonary_circulatio | 1.20905125 |
| 76 | MP0008058_abnormal_DNA_repair | 1.20001451 |
| 77 | MP0000858_altered_metastatic_potential | 1.19050920 |
| 78 | MP0001756_abnormal_urination | 1.18472299 |
| 79 | MP0002751_abnormal_autonomic_nervous | 1.15583194 |
| 80 | MP0003938_abnormal_ear_development | 1.15169903 |
| 81 | MP0003183_abnormal_peptide_metabolism | 1.14008335 |
| 82 | MP0000516_abnormal_urinary_system | 1.13209588 |
| 83 | MP0005367_renal/urinary_system_phenotyp | 1.13209588 |
| 84 | MP0008469_abnormal_protein_level | 1.12996633 |
| 85 | MP0002064_seizures | 1.12470339 |
| 86 | MP0005397_hematopoietic_system_phenotyp | 1.12363417 |
| 87 | MP0001545_abnormal_hematopoietic_system | 1.12363417 |
| 88 | MP0005174_abnormal_tail_pigmentation | 1.10417467 |
| 89 | MP0008932_abnormal_embryonic_tissue | 1.10308952 |
| 90 | MP0010155_abnormal_intestine_physiology | 1.09501049 |
| 91 | MP0004147_increased_porphyrin_level | 1.09372684 |
| 92 | MP0002095_abnormal_skin_pigmentation | 1.08637411 |
| 93 | MP0003693_abnormal_embryo_hatching | 1.08468987 |
| 94 | MP0005410_abnormal_fertilization | 1.08463345 |
| 95 | MP0002735_abnormal_chemical_nociception | 1.08447719 |
| 96 | MP0001986_abnormal_taste_sensitivity | 1.06449957 |
| 97 | MP0003786_premature_aging | 1.03569773 |
| 98 | MP0005253_abnormal_eye_physiology | 1.03214121 |
| 99 | MP0005379_endocrine/exocrine_gland_phen | 1.03193959 |
| 100 | MP0004019_abnormal_vitamin_homeostasis | 1.02559749 |
| 101 | MP0001529_abnormal_vocalization | 1.01738903 |
| 102 | MP0009745_abnormal_behavioral_response | 0.99908871 |
| 103 | MP0009764_decreased_sensitivity_to | 0.96534765 |
| 104 | MP0003635_abnormal_synaptic_transmissio | 0.96295204 |
| 105 | MP0003448_altered_tumor_morphology | 0.95849843 |
| 106 | MP0001970_abnormal_pain_threshold | 0.94891348 |
| 107 | MP0004957_abnormal_blastocyst_morpholog | 0.94788190 |
| 108 | MP0000681_abnormal_thyroid_gland | 0.94639717 |
| 109 | MP0010386_abnormal_urinary_bladder | 0.94315950 |
| 110 | MP0005551_abnormal_eye_electrophysiolog | 0.93892502 |
| 111 | MP0002734_abnormal_mechanical_nocicepti | 0.93434472 |
| 112 | MP0003172_abnormal_lysosome_physiology | 0.93299388 |
| 113 | MP0002396_abnormal_hematopoietic_system | 0.93264733 |
| 114 | MP0003191_abnormal_cellular_cholesterol | 0.92792232 |
| 115 | MP0003866_abnormal_defecation | 0.91507055 |
| 116 | MP0009379_abnormal_foot_pigmentation | 0.88574380 |
| 117 | MP0002132_abnormal_respiratory_system | 0.88490979 |
| 118 | MP0008875_abnormal_xenobiotic_pharmacok | 0.88295353 |
| 119 | MP0003879_abnormal_hair_cell | 0.88142981 |
| 120 | MP0002557_abnormal_social/conspecific_i | 0.87525228 |
| 121 | MP0002063_abnormal_learning/memory/cond | 0.87187731 |
| 122 | MP0001542_abnormal_bone_strength | 0.87065726 |
| 123 | MP0006036_abnormal_mitochondrial_physio | 0.86596964 |
| 124 | MP0005171_absent_coat_pigmentation | 0.86416037 |
| 125 | MP0002638_abnormal_pupillary_reflex | 0.86055219 |
| 126 | MP0002733_abnormal_thermal_nociception | 0.85385743 |
| 127 | MP0004808_abnormal_hematopoietic_stem | 0.85256221 |
| 128 | MP0002933_joint_inflammation | 0.85080273 |
| 129 | MP0005332_abnormal_amino_acid | 0.85046631 |
| 130 | MP0002272_abnormal_nervous_system | 0.85028046 |
| 131 | MP0001293_anophthalmia | 0.84958644 |
| 132 | MP0005423_abnormal_somatic_nervous | 0.84606739 |
| 133 | MP0009697_abnormal_copulation | 0.84199514 |
| 134 | MP0000631_abnormal_neuroendocrine_gland | 0.83758503 |
| 135 | MP0001879_abnormal_lymphatic_vessel | 0.83392544 |
| 136 | MP0000026_abnormal_inner_ear | 0.83022550 |
| 137 | MP0008872_abnormal_physiological_respon | 0.82756140 |
| 138 | MP0000490_abnormal_crypts_of | 0.82424107 |
| 139 | MP0008007_abnormal_cellular_replicative | 0.82028424 |
| 140 | MP0002998_abnormal_bone_remodeling | 0.81938789 |
| 141 | MP0003283_abnormal_digestive_organ | 0.81336650 |
| 142 | MP0000358_abnormal_cell_content/ | 0.80953622 |
| 143 | MP0005636_abnormal_mineral_homeostasis | 0.80890277 |
| 144 | MP0001348_abnormal_lacrimal_gland | 0.80476860 |
| 145 | MP0005075_abnormal_melanosome_morpholog | 0.79509932 |
| 146 | MP0005166_decreased_susceptibility_to | 0.79505155 |
| 147 | MP0008004_abnormal_stomach_pH | 0.79329595 |
| 148 | MP0004782_abnormal_surfactant_physiolog | 0.78706120 |
| 149 | MP0001501_abnormal_sleep_pattern | 0.78662257 |
| 150 | MP0000049_abnormal_middle_ear | 0.78475605 |
| 151 | MP0005164_abnormal_response_to | 0.77578528 |
| 152 | MP0000372_irregular_coat_pigmentation | 0.76687788 |
| 153 | MP0005645_abnormal_hypothalamus_physiol | 0.76423020 |
| 154 | MP0004947_skin_inflammation | 0.75777934 |
| 155 | MP0002837_dystrophic_cardiac_calcinosis | 0.75344151 |
| 156 | MP0000703_abnormal_thymus_morphology | 0.74574835 |
| 157 | MP0004133_heterotaxia | 0.72894999 |
| 158 | MP0009046_muscle_twitch | 0.72625997 |
| 159 | MP0001188_hyperpigmentation | 0.72226711 |
| 160 | MP0002572_abnormal_emotion/affect_behav | 0.72000847 |
| 161 | MP0008438_abnormal_cutaneous_collagen | 0.69962953 |
| 162 | MP0001485_abnormal_pinna_reflex | 0.69691242 |
| 163 | MP0002184_abnormal_innervation | 0.69370029 |
| 164 | MP0005084_abnormal_gallbladder_morpholo | 0.69220967 |
| 165 | MP0005503_abnormal_tendon_morphology | 0.69174022 |
| 166 | MP0004883_abnormal_blood_vessel | 0.69025456 |
| 167 | MP0005083_abnormal_biliary_tract | 0.68285176 |
| 168 | MP0001764_abnormal_homeostasis | 0.67986071 |
| 169 | MP0003315_abnormal_perineum_morphology | 0.63297702 |
| 170 | MP0002233_abnormal_nose_morphology | 0.62944479 |
| 171 | MP0002752_abnormal_somatic_nervous | 0.62245674 |
| 172 | MP0004742_abnormal_vestibular_system | 0.61523395 |
| 173 | MP0000647_abnormal_sebaceous_gland | 0.61491443 |
| 174 | MP0001324_abnormal_eye_pigmentation | 0.61385900 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Recurrent abscess formation (HP:0002722) | 4.94668854 |
| 2 | Recurrent bacterial skin infections (HP:0005406) | 4.25187833 |
| 3 | Cerebral edema (HP:0002181) | 4.00008634 |
| 4 | Eczematoid dermatitis (HP:0000976) | 3.93213191 |
| 5 | Macrocytic anemia (HP:0001972) | 3.88560028 |
| 6 | Acute necrotizing encephalopathy (HP:0006965) | 3.82832456 |
| 7 | Hepatocellular necrosis (HP:0001404) | 3.77911278 |
| 8 | Mitochondrial inheritance (HP:0001427) | 3.73126991 |
| 9 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.70369669 |
| 10 | Abnormality of macrophages (HP:0004311) | 3.69918631 |
| 11 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.45670351 |
| 12 | Generalized aminoaciduria (HP:0002909) | 3.34671508 |
| 13 | Hepatic necrosis (HP:0002605) | 3.29448271 |
| 14 | Abnormality of renal resorption (HP:0011038) | 3.28845907 |
| 15 | Increased muscle lipid content (HP:0009058) | 3.28485718 |
| 16 | Vacuolated lymphocytes (HP:0001922) | 3.22859439 |
| 17 | Mediastinal lymphadenopathy (HP:0100721) | 3.22595096 |
| 18 | Increased CSF lactate (HP:0002490) | 3.21517480 |
| 19 | Increased IgM level (HP:0003496) | 3.19264504 |
| 20 | Agnosia (HP:0010524) | 3.11914173 |
| 21 | Progressive macrocephaly (HP:0004481) | 3.08908700 |
| 22 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.08713896 |
| 23 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.08713896 |
| 24 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 3.07792252 |
| 25 | Abnormality of the anterior horn cell (HP:0006802) | 2.98155115 |
| 26 | Degeneration of anterior horn cells (HP:0002398) | 2.98155115 |
| 27 | Poor head control (HP:0002421) | 2.97817318 |
| 28 | Obstructive lung disease (HP:0006536) | 2.97390980 |
| 29 | Chronic obstructive pulmonary disease (HP:0006510) | 2.97390980 |
| 30 | Optic disc pallor (HP:0000543) | 2.91826766 |
| 31 | Leukodystrophy (HP:0002415) | 2.85514512 |
| 32 | Increased cerebral lipofuscin (HP:0011813) | 2.84246207 |
| 33 | Petechiae (HP:0000967) | 2.80758082 |
| 34 | Aplastic anemia (HP:0001915) | 2.78695877 |
| 35 | Myositis (HP:0100614) | 2.78572069 |
| 36 | Thrombocytosis (HP:0001894) | 2.77260343 |
| 37 | Acute encephalopathy (HP:0006846) | 2.76607650 |
| 38 | Type I transferrin isoform profile (HP:0003642) | 2.76422334 |
| 39 | Basal ganglia calcification (HP:0002135) | 2.67042301 |
| 40 | Focal motor seizures (HP:0011153) | 2.66483552 |
| 41 | Exertional dyspnea (HP:0002875) | 2.65167267 |
| 42 | Glycosuria (HP:0003076) | 2.65090460 |
| 43 | Abnormality of urine glucose concentration (HP:0011016) | 2.65090460 |
| 44 | Congenital, generalized hypertrichosis (HP:0004540) | 2.65040668 |
| 45 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 2.61519603 |
| 46 | Stomatitis (HP:0010280) | 2.61380365 |
| 47 | Neuroendocrine neoplasm (HP:0100634) | 2.59565089 |
| 48 | Recurrent skin infections (HP:0001581) | 2.58760812 |
| 49 | Abnormality of glycolipid metabolism (HP:0010969) | 2.57860756 |
| 50 | Abnormality of liposaccharide metabolism (HP:0010968) | 2.57860756 |
| 51 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 2.57860756 |
| 52 | Recurrent fungal infections (HP:0002841) | 2.55536286 |
| 53 | Lethargy (HP:0001254) | 2.52930278 |
| 54 | Hyperphosphaturia (HP:0003109) | 2.51908597 |
| 55 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.49305224 |
| 56 | Respiratory failure (HP:0002878) | 2.48807547 |
| 57 | Prolonged neonatal jaundice (HP:0006579) | 2.45480365 |
| 58 | Pallor (HP:0000980) | 2.41486838 |
| 59 | X-linked dominant inheritance (HP:0001423) | 2.40803183 |
| 60 | Increased hepatocellular lipid droplets (HP:0006565) | 2.40493541 |
| 61 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 2.37533749 |
| 62 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.32205113 |
| 63 | Hypergammaglobulinemia (HP:0010702) | 2.30322371 |
| 64 | Dysostosis multiplex (HP:0000943) | 2.27294572 |
| 65 | Medial flaring of the eyebrow (HP:0010747) | 2.25691781 |
| 66 | Increased serum lactate (HP:0002151) | 2.23712898 |
| 67 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.22914188 |
| 68 | Systemic lupus erythematosus (HP:0002725) | 2.22630346 |
| 69 | Chronic otitis media (HP:0000389) | 2.20853972 |
| 70 | Abnormal glycosylation (HP:0012345) | 2.20120474 |
| 71 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.20120474 |
| 72 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.20120474 |
| 73 | Abnormal protein glycosylation (HP:0012346) | 2.20120474 |
| 74 | Recurrent viral infections (HP:0004429) | 2.19576354 |
| 75 | Autoimmune thrombocytopenia (HP:0001973) | 2.18098219 |
| 76 | Nausea (HP:0002018) | 2.17579204 |
| 77 | Meningitis (HP:0001287) | 2.17475072 |
| 78 | Retrobulbar optic neuritis (HP:0100654) | 2.17175285 |
| 79 | Optic neuritis (HP:0100653) | 2.17175285 |
| 80 | Abnormal number of erythroid precursors (HP:0012131) | 2.16202985 |
| 81 | IgG deficiency (HP:0004315) | 2.16166888 |
| 82 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.16007269 |
| 83 | Exercise intolerance (HP:0003546) | 2.15736482 |
| 84 | Vertebral compression fractures (HP:0002953) | 2.15366636 |
| 85 | Interstitial pulmonary disease (HP:0006530) | 2.14819502 |
| 86 | Hypothermia (HP:0002045) | 2.13564779 |
| 87 | Abnormal pupillary function (HP:0007686) | 2.13445552 |
| 88 | CNS demyelination (HP:0007305) | 2.12005867 |
| 89 | Orchitis (HP:0100796) | 2.11223404 |
| 90 | Polyphagia (HP:0002591) | 2.10017135 |
| 91 | Abnormality of placental membranes (HP:0011409) | 2.08965294 |
| 92 | Amniotic constriction ring (HP:0009775) | 2.08965294 |
| 93 | Pheochromocytoma (HP:0002666) | 2.08733106 |
| 94 | Birth length less than 3rd percentile (HP:0003561) | 2.06893134 |
| 95 | Abnormal hair whorl (HP:0010721) | 2.06109136 |
| 96 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.05657400 |
| 97 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.05636123 |
| 98 | Increased intramyocellular lipid droplets (HP:0012240) | 2.05338058 |
| 99 | Lactic acidosis (HP:0003128) | 2.04858132 |
| 100 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 2.04803525 |
| 101 | Renal Fanconi syndrome (HP:0001994) | 2.04338182 |
| 102 | Cellulitis (HP:0100658) | 2.04247087 |
| 103 | Vasculitis (HP:0002633) | 2.03774929 |
| 104 | Hypoglycemic coma (HP:0001325) | 2.02934340 |
| 105 | Reduced antithrombin III activity (HP:0001976) | 2.02142464 |
| 106 | Neutropenia (HP:0001875) | 2.01787686 |
| 107 | Gingivitis (HP:0000230) | 2.01477186 |
| 108 | Methylmalonic acidemia (HP:0002912) | 2.00695579 |
| 109 | Abnormal ciliary motility (HP:0012262) | 1.98702690 |
| 110 | Eosinophilia (HP:0001880) | 1.98580662 |
| 111 | Reticulocytopenia (HP:0001896) | 1.97181180 |
| 112 | Lipid accumulation in hepatocytes (HP:0006561) | 1.96695362 |
| 113 | IgM deficiency (HP:0002850) | 1.95892463 |
| 114 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.95151805 |
| 115 | Cerebral hypomyelination (HP:0006808) | 1.94703289 |
| 116 | Methylmalonic aciduria (HP:0012120) | 1.92677302 |
| 117 | Purpura (HP:0000979) | 1.92419846 |
| 118 | Myokymia (HP:0002411) | 1.91214959 |
| 119 | Hepatosplenomegaly (HP:0001433) | 1.88762532 |
| 120 | Recurrent pneumonia (HP:0006532) | 1.88692780 |
| 121 | Pulmonary infiltrates (HP:0002113) | 1.88361014 |
| 122 | Renal tubular dysfunction (HP:0000124) | 1.88300168 |
| 123 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.87817164 |
| 124 | Dicarboxylic aciduria (HP:0003215) | 1.87817164 |
| 125 | Pulmonary fibrosis (HP:0002206) | 1.87778230 |
| 126 | Congenital ichthyosiform erythroderma (HP:0007431) | 1.86213025 |
| 127 | Blindness (HP:0000618) | 1.86043201 |
| 128 | Increased serum pyruvate (HP:0003542) | 1.84048683 |
| 129 | Abnormality of glycolysis (HP:0004366) | 1.84048683 |
| 130 | Heterochromia iridis (HP:0001100) | 1.83893213 |
| 131 | Stenosis of the external auditory canal (HP:0000402) | 1.83430636 |
| 132 | Epileptic encephalopathy (HP:0200134) | 1.82281445 |
| 133 | Pancreatic fibrosis (HP:0100732) | 1.82037227 |
| 134 | Pancreatic cysts (HP:0001737) | 1.79374773 |
| 135 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.79278087 |
| 136 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.79278087 |
| 137 | Poor suck (HP:0002033) | 1.78561140 |
| 138 | Respiratory difficulties (HP:0002880) | 1.77923204 |
| 139 | Gait imbalance (HP:0002141) | 1.77867180 |
| 140 | Cholecystitis (HP:0001082) | 1.77832632 |
| 141 | Abnormal gallbladder physiology (HP:0012438) | 1.77832632 |
| 142 | Congenital primary aphakia (HP:0007707) | 1.77828756 |
| 143 | True hermaphroditism (HP:0010459) | 1.77804273 |
| 144 | 3-Methylglutaconic aciduria (HP:0003535) | 1.77595867 |
| 145 | Granulocytopenia (HP:0001913) | 1.76807759 |
| 146 | Emotional lability (HP:0000712) | 1.76291319 |
| 147 | Abnormal urine phosphate concentration (HP:0012599) | 1.75922658 |
| 148 | Abnormality of methionine metabolism (HP:0010901) | 1.70418545 |
| 149 | Limb dystonia (HP:0002451) | 1.69351480 |
| 150 | Oral leukoplakia (HP:0002745) | 1.67791905 |
| 151 | Concave nail (HP:0001598) | 1.62045604 |
| 152 | Microvesicular hepatic steatosis (HP:0001414) | 1.61880680 |
| 153 | Abnormal hemoglobin (HP:0011902) | 1.60931479 |
| 154 | Nephrogenic diabetes insipidus (HP:0009806) | 1.59236301 |
| 155 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.59052977 |
| 156 | Vomiting (HP:0002013) | 1.58338499 |
| 157 | Retinal dysplasia (HP:0007973) | 1.57679997 |
| 158 | Septo-optic dysplasia (HP:0100842) | 1.56890886 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 4.59819484 |
| 2 | MAP3K12 | 4.10128924 |
| 3 | RIPK4 | 3.92216870 |
| 4 | ARAF | 3.39587016 |
| 5 | NME2 | 3.18244468 |
| 6 | PIM2 | 2.54970159 |
| 7 | MAP3K14 | 2.37269448 |
| 8 | STK16 | 2.20902387 |
| 9 | CDK19 | 2.08459196 |
| 10 | BMPR2 | 2.04629023 |
| 11 | BLK | 2.01003291 |
| 12 | DAPK1 | 1.92492400 |
| 13 | DYRK2 | 1.90570810 |
| 14 | PRPF4B | 1.85795551 |
| 15 | TRIM28 | 1.83340787 |
| 16 | BUB1 | 1.82357507 |
| 17 | BCKDK | 1.81490740 |
| 18 | EIF2AK1 | 1.75177320 |
| 19 | TESK2 | 1.74374268 |
| 20 | MST4 | 1.72813309 |
| 21 | MAP2K7 | 1.70595063 |
| 22 | EIF2AK3 | 1.70586760 |
| 23 | MYLK | 1.66476498 |
| 24 | TESK1 | 1.64994216 |
| 25 | EPHB2 | 1.64848955 |
| 26 | NME1 | 1.61293660 |
| 27 | SIK3 | 1.60392424 |
| 28 | TBK1 | 1.59893720 |
| 29 | BRAF | 1.59235670 |
| 30 | KIT | 1.50631712 |
| 31 | SYK | 1.50330246 |
| 32 | TXK | 1.50076469 |
| 33 | ZAK | 1.48774056 |
| 34 | MAP3K13 | 1.45749439 |
| 35 | TSSK6 | 1.43044853 |
| 36 | MAP4K1 | 1.40897218 |
| 37 | IKBKB | 1.39853953 |
| 38 | IRAK4 | 1.38359295 |
| 39 | SCYL2 | 1.37366086 |
| 40 | CASK | 1.36489595 |
| 41 | ZAP70 | 1.36177336 |
| 42 | LRRK2 | 1.35446286 |
| 43 | CCNB1 | 1.32107115 |
| 44 | WNK3 | 1.31651067 |
| 45 | TYK2 | 1.28360655 |
| 46 | PBK | 1.26184304 |
| 47 | RAF1 | 1.24758240 |
| 48 | JAK3 | 1.23938930 |
| 49 | PLK3 | 1.22209404 |
| 50 | PDK2 | 1.20409612 |
| 51 | PLK2 | 1.19424650 |
| 52 | PASK | 1.15151061 |
| 53 | CAMKK2 | 1.12538026 |
| 54 | WEE1 | 1.09021881 |
| 55 | VRK1 | 1.06660466 |
| 56 | ADRBK2 | 1.06339167 |
| 57 | CSNK1G3 | 1.06111584 |
| 58 | ACVR1B | 1.04955574 |
| 59 | ABL2 | 1.03763991 |
| 60 | GRK1 | 0.99988925 |
| 61 | IKBKE | 0.97095064 |
| 62 | EPHA4 | 0.96584168 |
| 63 | DYRK3 | 0.96473154 |
| 64 | KSR2 | 0.95496561 |
| 65 | PAK3 | 0.94311381 |
| 66 | TLK1 | 0.93356248 |
| 67 | BCR | 0.93083554 |
| 68 | DAPK3 | 0.92543048 |
| 69 | ILK | 0.91933908 |
| 70 | CSNK1G2 | 0.91558719 |
| 71 | INSRR | 0.90557145 |
| 72 | MAP4K2 | 0.89792910 |
| 73 | KDR | 0.85595073 |
| 74 | LIMK1 | 0.82940329 |
| 75 | DAPK2 | 0.82589407 |
| 76 | MAPK15 | 0.81258941 |
| 77 | MAP3K11 | 0.81034082 |
| 78 | TIE1 | 0.79206844 |
| 79 | LYN | 0.78568964 |
| 80 | MINK1 | 0.77615927 |
| 81 | CSNK1G1 | 0.75564379 |
| 82 | PINK1 | 0.73871127 |
| 83 | FES | 0.73325826 |
| 84 | GRK6 | 0.71229783 |
| 85 | TEC | 0.70888525 |
| 86 | MARK1 | 0.69877931 |
| 87 | BMPR1B | 0.69855268 |
| 88 | NEK9 | 0.68380546 |
| 89 | BTK | 0.67298434 |
| 90 | PRKCD | 0.67237645 |
| 91 | IRAK3 | 0.66775754 |
| 92 | ADRBK1 | 0.66739766 |
| 93 | PNCK | 0.63037457 |
| 94 | CSNK2A2 | 0.63002323 |
| 95 | MAP2K3 | 0.62192884 |
| 96 | CSNK1A1L | 0.60767038 |
| 97 | MOS | 0.60267018 |
| 98 | GRK7 | 0.59884792 |
| 99 | TGFBR1 | 0.59873001 |
| 100 | GRK5 | 0.59710850 |
| 101 | CSF1R | 0.59160763 |
| 102 | CSNK2A1 | 0.57388373 |
| 103 | NUAK1 | 0.57080084 |
| 104 | TAF1 | 0.56792211 |
| 105 | MAPKAPK3 | 0.55549463 |
| 106 | NTRK3 | 0.54769049 |
| 107 | STK24 | 0.53949809 |
| 108 | AURKA | 0.51981462 |
| 109 | PRKCE | 0.51180501 |
| 110 | LCK | 0.51071621 |
| 111 | PTK2B | 0.50956517 |
| 112 | CLK1 | 0.48909926 |
| 113 | CAMK2G | 0.47622409 |
| 114 | MAP3K9 | 0.46757375 |
| 115 | CDC7 | 0.45808080 |
| 116 | KSR1 | 0.43625067 |
| 117 | PAK1 | 0.42348619 |
| 118 | PLK1 | 0.41573560 |
| 119 | CDK14 | 0.41318933 |
| 120 | PIM1 | 0.41048826 |
| 121 | JAK1 | 0.40838489 |
| 122 | PAK4 | 0.40103830 |
| 123 | PAK2 | 0.39697613 |
| 124 | CAMK2D | 0.39586812 |
| 125 | CDK18 | 0.38853479 |
| 126 | ROCK2 | 0.38034911 |
| 127 | BRSK1 | 0.37777871 |
| 128 | MAP3K4 | 0.37161122 |
| 129 | PRKCG | 0.36710063 |
| 130 | EIF2AK2 | 0.36587899 |
| 131 | OXSR1 | 0.36193515 |
| 132 | RPS6KA5 | 0.35837993 |
| 133 | CDK8 | 0.35743359 |
| 134 | PHKG2 | 0.35194755 |
| 135 | PHKG1 | 0.35194755 |
| 136 | PLK4 | 0.35150917 |
| 137 | MUSK | 0.34789012 |
| 138 | MAPKAPK2 | 0.34261096 |
| 139 | NEK1 | 0.32886871 |
| 140 | CAMK2A | 0.32644498 |
| 141 | MAP3K1 | 0.31113143 |
| 142 | TNIK | 0.30564180 |
| 143 | CHUK | 0.29980121 |
| 144 | CDK15 | 0.29267172 |
| 145 | RPS6KA4 | 0.28816231 |
| 146 | SRPK1 | 0.28594060 |
| 147 | CDK11A | 0.27348610 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.43640978 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.82276095 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 2.54649565 |
| 4 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.43007536 |
| 5 | Parkinsons disease_Homo sapiens_hsa05012 | 2.33413154 |
| 6 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.25295153 |
| 7 | Protein export_Homo sapiens_hsa03060 | 2.16902871 |
| 8 | Fatty acid elongation_Homo sapiens_hsa00062 | 2.13488551 |
| 9 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.05329603 |
| 10 | RNA polymerase_Homo sapiens_hsa03020 | 2.02964179 |
| 11 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 2.01492643 |
| 12 | Allograft rejection_Homo sapiens_hsa05330 | 2.00389554 |
| 13 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.93560524 |
| 14 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.76085788 |
| 15 | Leishmaniasis_Homo sapiens_hsa05140 | 1.73258771 |
| 16 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.70759720 |
| 17 | DNA replication_Homo sapiens_hsa03030 | 1.70030893 |
| 18 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.69289438 |
| 19 | Alzheimers disease_Homo sapiens_hsa05010 | 1.67782158 |
| 20 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.65051612 |
| 21 | Shigellosis_Homo sapiens_hsa05131 | 1.62412231 |
| 22 | Legionellosis_Homo sapiens_hsa05134 | 1.62034469 |
| 23 | Huntingtons disease_Homo sapiens_hsa05016 | 1.58213303 |
| 24 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.55932494 |
| 25 | Phagosome_Homo sapiens_hsa04145 | 1.53548829 |
| 26 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.47931824 |
| 27 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.46185527 |
| 28 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.46132588 |
| 29 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 1.40908273 |
| 30 | Lysosome_Homo sapiens_hsa04142 | 1.39179350 |
| 31 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.37749200 |
| 32 | Pertussis_Homo sapiens_hsa05133 | 1.35979919 |
| 33 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.31861820 |
| 34 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.30639101 |
| 35 | Tuberculosis_Homo sapiens_hsa05152 | 1.29709817 |
| 36 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.26961261 |
| 37 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.25565463 |
| 38 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.25263740 |
| 39 | Salmonella infection_Homo sapiens_hsa05132 | 1.24590210 |
| 40 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.22798098 |
| 41 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.20367437 |
| 42 | Other glycan degradation_Homo sapiens_hsa00511 | 1.18411735 |
| 43 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.16170467 |
| 44 | Mismatch repair_Homo sapiens_hsa03430 | 1.16170338 |
| 45 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.09867636 |
| 46 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.09591582 |
| 47 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.09449785 |
| 48 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.05513182 |
| 49 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.05406146 |
| 50 | Asthma_Homo sapiens_hsa05310 | 1.04436816 |
| 51 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.03452041 |
| 52 | Base excision repair_Homo sapiens_hsa03410 | 1.03170519 |
| 53 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.02470170 |
| 54 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.01542389 |
| 55 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.00935865 |
| 56 | Measles_Homo sapiens_hsa05162 | 0.97720963 |
| 57 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.96752443 |
| 58 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.96650090 |
| 59 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.95788308 |
| 60 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.94896072 |
| 61 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.94015354 |
| 62 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.93889512 |
| 63 | Peroxisome_Homo sapiens_hsa04146 | 0.93397851 |
| 64 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.91818825 |
| 65 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.91811226 |
| 66 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.88081210 |
| 67 | Sulfur relay system_Homo sapiens_hsa04122 | 0.88016052 |
| 68 | Metabolic pathways_Homo sapiens_hsa01100 | 0.85229268 |
| 69 | Homologous recombination_Homo sapiens_hsa03440 | 0.84592039 |
| 70 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.83499686 |
| 71 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.80246499 |
| 72 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.78417174 |
| 73 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.77469895 |
| 74 | Apoptosis_Homo sapiens_hsa04210 | 0.76581846 |
| 75 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.76217710 |
| 76 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.75909555 |
| 77 | Influenza A_Homo sapiens_hsa05164 | 0.75822861 |
| 78 | Purine metabolism_Homo sapiens_hsa00230 | 0.75355100 |
| 79 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.75335583 |
| 80 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.75184297 |
| 81 | Carbon metabolism_Homo sapiens_hsa01200 | 0.74998339 |
| 82 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.74321532 |
| 83 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.73043899 |
| 84 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.71482953 |
| 85 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.70453109 |
| 86 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.70053023 |
| 87 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.69631884 |
| 88 | Olfactory transduction_Homo sapiens_hsa04740 | 0.69595646 |
| 89 | Long-term potentiation_Homo sapiens_hsa04720 | 0.68192870 |
| 90 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.66498836 |
| 91 | Malaria_Homo sapiens_hsa05144 | 0.66479296 |
| 92 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.63942387 |
| 93 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.63538364 |
| 94 | RNA degradation_Homo sapiens_hsa03018 | 0.63527459 |
| 95 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.62494656 |
| 96 | Spliceosome_Homo sapiens_hsa03040 | 0.61988245 |
| 97 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.59291134 |
| 98 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.58561375 |
| 99 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.58396870 |
| 100 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.58261200 |
| 101 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.57732504 |
| 102 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.57583573 |
| 103 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.57556539 |
| 104 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.56275003 |
| 105 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.56212143 |
| 106 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.56049731 |
| 107 | Hepatitis B_Homo sapiens_hsa05161 | 0.55133956 |
| 108 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.53762725 |
| 109 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.53126571 |
| 110 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.52948622 |
| 111 | Phototransduction_Homo sapiens_hsa04744 | 0.52746479 |
| 112 | Morphine addiction_Homo sapiens_hsa05032 | 0.52306827 |
| 113 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.51262499 |
| 114 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.50196770 |
| 115 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.48037524 |
| 116 | Nicotine addiction_Homo sapiens_hsa05033 | 0.47596101 |
| 117 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.47341739 |
| 118 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.46893198 |
| 119 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.45831009 |
| 120 | Viral myocarditis_Homo sapiens_hsa05416 | 0.45824771 |
| 121 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.45799481 |
| 122 | Basal transcription factors_Homo sapiens_hsa03022 | 0.44617212 |
| 123 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.44474979 |
| 124 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.44223508 |
| 125 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.40137301 |
| 126 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.38746553 |
| 127 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.36888349 |
| 128 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.36871888 |
| 129 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.35555688 |
| 130 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.35527300 |
| 131 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.35375278 |
| 132 | Circadian entrainment_Homo sapiens_hsa04713 | 0.35332015 |
| 133 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.34053767 |
| 134 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.33657443 |
| 135 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.33378268 |
| 136 | RNA transport_Homo sapiens_hsa03013 | 0.33359755 |
| 137 | Galactose metabolism_Homo sapiens_hsa00052 | 0.32929794 |
| 138 | Endocytosis_Homo sapiens_hsa04144 | 0.32874456 |
| 139 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.32618808 |
| 140 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.31874226 |
| 141 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.31564860 |
| 142 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.31385179 |
| 143 | GABAergic synapse_Homo sapiens_hsa04727 | 0.31232918 |
| 144 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.31128746 |
| 145 | Mineral absorption_Homo sapiens_hsa04978 | 0.30627412 |
| 146 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.30562373 |
| 147 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.29671731 |
| 148 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.29367324 |
| 149 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.26458111 |
| 150 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.22367676 |
| 151 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.21871355 |
| 152 | Retinol metabolism_Homo sapiens_hsa00830 | 0.21865254 |
| 153 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.18894145 |
| 154 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.18817731 |
| 155 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.18361063 |
| 156 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.17155629 |
| 157 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.12845144 |

