BRMS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.45578718
2ribosomal small subunit assembly (GO:0000028)4.14988275
3formation of translation preinitiation complex (GO:0001731)4.12996287
4negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.03220504
5protein maturation by protein folding (GO:0022417)3.98971344
6DNA strand elongation involved in DNA replication (GO:0006271)3.90320660
7DNA strand elongation (GO:0022616)3.77437523
8proteasome assembly (GO:0043248)3.74013741
9telomere maintenance via semi-conservative replication (GO:0032201)3.70723554
10purine nucleobase biosynthetic process (GO:0009113)3.69258015
11nucleobase biosynthetic process (GO:0046112)3.63467623
12GDP-mannose metabolic process (GO:0019673)3.63169084
13ribosome biogenesis (GO:0042254)3.45668885
14nucleobase-containing small molecule interconversion (GO:0015949)3.44275603
15negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.43649718
16negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.42262549
17telomere maintenance via recombination (GO:0000722)3.39760026
18DNA replication checkpoint (GO:0000076)3.38139158
19mitotic metaphase plate congression (GO:0007080)3.37875525
20anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.32155469
21establishment of viral latency (GO:0019043)3.31818760
22regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.31651877
23pyrimidine nucleoside salvage (GO:0043097)3.30463690
24pyrimidine-containing compound salvage (GO:0008655)3.30463690
25maturation of SSU-rRNA (GO:0030490)3.29749100
26establishment of integrated proviral latency (GO:0075713)3.27856662
27positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.27111912
28DNA replication initiation (GO:0006270)3.22048920
29nucleoside salvage (GO:0043174)3.17398888
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.17398643
31negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.17350712
32negative regulation of ligase activity (GO:0051352)3.17350712
33ribonucleoprotein complex biogenesis (GO:0022613)3.14939837
34protein localization to kinetochore (GO:0034501)3.11931667
35DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.11183173
36pentose-phosphate shunt (GO:0006098)3.10755239
37protein localization to chromosome, centromeric region (GO:0071459)3.09575963
38antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.09229375
39intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.05687834
40signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.05687834
41signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.05068950
42signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.05068950
43signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.05068950
44mitotic nuclear envelope disassembly (GO:0007077)3.03163737
45mitotic recombination (GO:0006312)3.01443050
46ribosomal large subunit biogenesis (GO:0042273)3.00350085
47nuclear envelope reassembly (GO:0031468)2.98912664
48mitotic nuclear envelope reassembly (GO:0007084)2.98912664
49regulation of cellular amino acid metabolic process (GO:0006521)2.97983842
50NIK/NF-kappaB signaling (GO:0038061)2.97715308
51telomere maintenance via telomere lengthening (GO:0010833)2.97562957
52negative regulation of protein ubiquitination (GO:0031397)2.97418306
53signal transduction involved in DNA damage checkpoint (GO:0072422)2.97047677
54signal transduction involved in DNA integrity checkpoint (GO:0072401)2.97047677
55protein targeting to mitochondrion (GO:0006626)2.96874200
56maturation of 5.8S rRNA (GO:0000460)2.94724196
57regulation of cellular amine metabolic process (GO:0033238)2.94632864
58signal transduction involved in cell cycle checkpoint (GO:0072395)2.92511199
59NADPH regeneration (GO:0006740)2.91606467
60spliceosomal snRNP assembly (GO:0000387)2.91128242
61L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.91056910
62Golgi transport vesicle coating (GO:0048200)2.90610495
63COPI coating of Golgi vesicle (GO:0048205)2.90610495
64regulation of translation in response to stress (GO:0043555)2.90193787
65rRNA processing (GO:0006364)2.89569363
66negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.89488679
67positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.89453744
68nucleotide salvage (GO:0043173)2.89115204
69deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.88324368
70chaperone-mediated protein transport (GO:0072321)2.87888801
71translational initiation (GO:0006413)2.87092708
72rRNA modification (GO:0000154)2.86036120
73regulation of mitochondrial translation (GO:0070129)2.85361554
74viral transcription (GO:0019083)2.84458094
75establishment of protein localization to mitochondrial membrane (GO:0090151)2.83611632
76establishment of chromosome localization (GO:0051303)2.80988477
77regulation of translational termination (GO:0006449)2.80860938
78attachment of spindle microtubules to kinetochore (GO:0008608)2.80134444
79guanosine-containing compound biosynthetic process (GO:1901070)2.78118242
80translational termination (GO:0006415)2.77931200
81rRNA metabolic process (GO:0016072)2.77842803
82ribosomal small subunit biogenesis (GO:0042274)2.77802872
83positive regulation of ligase activity (GO:0051351)2.77323526
84regulation of superoxide anion generation (GO:0032928)2.76228380
85pentose metabolic process (GO:0019321)2.75978114
86pseudouridine synthesis (GO:0001522)2.75632368
87CENP-A containing nucleosome assembly (GO:0034080)2.75241278
88membrane disassembly (GO:0030397)2.74752401
89nuclear envelope disassembly (GO:0051081)2.74752401
90metaphase plate congression (GO:0051310)2.74712284
91termination of RNA polymerase III transcription (GO:0006386)2.74415880
92transcription elongation from RNA polymerase III promoter (GO:0006385)2.74415880
93nucleotide-excision repair, DNA gap filling (GO:0006297)2.73211990
94translational elongation (GO:0006414)2.72681216
95signal transduction in response to DNA damage (GO:0042770)2.71193254
96antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.71041823
97antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.71041823
98regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.70099165
99establishment of protein localization to mitochondrion (GO:0072655)2.68641854
100G1/S transition of mitotic cell cycle (GO:0000082)2.66970950
101cell cycle G1/S phase transition (GO:0044843)2.66970950
102chromatin remodeling at centromere (GO:0031055)2.66908297
103mitotic sister chromatid segregation (GO:0000070)2.65499831
104transcription-coupled nucleotide-excision repair (GO:0006283)2.64843506
105protein localization to mitochondrion (GO:0070585)2.64415347
106ribosome assembly (GO:0042255)2.64253728
107regulation of ubiquitin-protein transferase activity (GO:0051438)2.64130277
108metallo-sulfur cluster assembly (GO:0031163)2.63404231
109iron-sulfur cluster assembly (GO:0016226)2.63404231
110regulation of cell cycle arrest (GO:0071156)2.63346055
111antigen processing and presentation of endogenous antigen (GO:0019883)2.63339421
112glucose catabolic process (GO:0006007)2.63236264
113chaperone mediated protein folding requiring cofactor (GO:0051085)2.62280726
1147-methylguanosine mRNA capping (GO:0006370)2.60849206
115activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.60809973
116amino acid salvage (GO:0043102)2.60645262
117L-methionine salvage (GO:0071267)2.60645262
118L-methionine biosynthetic process (GO:0071265)2.60645262
119protein deneddylation (GO:0000338)2.58645499
120DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.57525717
121Arp2/3 complex-mediated actin nucleation (GO:0034314)2.57270528
122regulation of double-strand break repair via homologous recombination (GO:0010569)2.55790153
123regulation of ligase activity (GO:0051340)2.55025539
124SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.53175853
125positive regulation of cell cycle arrest (GO:0071158)2.52892915
126regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.52673483
127IMP biosynthetic process (GO:0006188)2.52583261
128GMP metabolic process (GO:0046037)2.51862051
129viral mRNA export from host cell nucleus (GO:0046784)2.51839782
1307-methylguanosine RNA capping (GO:0009452)2.51574346
131RNA capping (GO:0036260)2.51574346
132translation (GO:0006412)2.51088628
133DNA unwinding involved in DNA replication (GO:0006268)2.50412348
134regulation of spindle organization (GO:0090224)2.49243748
135negative regulation of cell cycle G1/S phase transition (GO:1902807)2.48975622
136negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.48975622
137purine nucleotide salvage (GO:0032261)2.46827794
138antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.46242948
139purine deoxyribonucleotide catabolic process (GO:0009155)2.46242925
140immunoglobulin mediated immune response (GO:0016064)2.45792550
141sequestering of actin monomers (GO:0042989)2.45722558
142cotranslational protein targeting to membrane (GO:0006613)2.41775422
143pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.40823430
144deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.40731436
145tRNA methylation (GO:0030488)2.39274701
146negative regulation of mitochondrion organization (GO:0010823)2.35479438
147pinocytosis (GO:0006907)2.34750732
148response to peptidoglycan (GO:0032494)2.31958636
149deoxyribose phosphate catabolic process (GO:0046386)2.30514762
150peptidyl-arginine omega-N-methylation (GO:0035247)2.30465972
151rRNA methylation (GO:0031167)2.30115965
152deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.29686609

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.72351179
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.65170151
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.33730273
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.99282965
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.91639034
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.90999057
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.89662723
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.86387002
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.84129472
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.79089529
11* ETS1_20019798_ChIP-Seq_JURKAT_Human2.71543990
12* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.58864167
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.54831103
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.49276720
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.44320003
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.28161058
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.26226276
18* ELF1_17652178_ChIP-ChIP_JURKAT_Human2.19770068
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.17890183
20VDR_23849224_ChIP-Seq_CD4+_Human2.15166262
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.11648211
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.10206019
23* XRN2_22483619_ChIP-Seq_HELA_Human2.08170702
24IRF8_21731497_ChIP-ChIP_J774_Mouse1.97502891
25DCP1A_22483619_ChIP-Seq_HELA_Human1.91143282
26NELFA_20434984_ChIP-Seq_ESCs_Mouse1.87145173
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.86314104
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.82633563
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.81756319
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81283615
31FOXP3_21729870_ChIP-Seq_TREG_Human1.80858104
32GABP_19822575_ChIP-Seq_HepG2_Human1.79593269
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.73924150
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.71850862
35MYC_22102868_ChIP-Seq_BL_Human1.71831056
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.71488015
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.65715615
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.60287929
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.59186306
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.55991283
41* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.55865066
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55533528
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55124542
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53968852
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.53470429
46TTF2_22483619_ChIP-Seq_HELA_Human1.47379503
47SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47288294
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47234590
49VDR_21846776_ChIP-Seq_THP-1_Human1.44712332
50SPI1_23547873_ChIP-Seq_NB4_Human1.44578623
51AR_21909140_ChIP-Seq_LNCAP_Human1.44333586
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.43868594
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.43738636
54* ELK3_25401928_ChIP-Seq_HUVEC_Human1.43163831
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42918115
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42738585
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39550231
58CIITA_25753668_ChIP-Seq_RAJI_Human1.39227640
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39061440
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37417883
61TP63_17297297_ChIP-ChIP_HaCaT_Human1.33356918
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.32282928
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32215911
64RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30565662
65ZNF263_19887448_ChIP-Seq_K562_Human1.28239207
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27290934
67* KDM5A_27292631_Chip-Seq_BREAST_Human1.26205489
68MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.24527755
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24078248
70ELK1_19687146_ChIP-ChIP_HELA_Human1.23732110
71MYB_21317192_ChIP-Seq_ERMYB_Mouse1.23110984
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21607631
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20974667
74* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19811620
75RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17135894
76* TET1_21451524_ChIP-Seq_MESCs_Mouse1.15782430
77STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14629447
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14595204
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13340517
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.11579643
81TFEB_21752829_ChIP-Seq_HELA_Human1.11231978
82SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10513665
83TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09878955
84LXR_22292898_ChIP-Seq_THP-1_Human1.09743639
85CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07453494
86RACK7_27058665_Chip-Seq_MCF-7_Human1.06732170
87SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06387594
88* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05866118
89NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04919468
90CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04064131
91* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03667341
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03463218
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03397859
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01911366
95MYB_26560356_Chip-Seq_TH2_Human1.01240026
96TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00829336
97ELF1_20517297_ChIP-Seq_JURKAT_Human1.00149659
98YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00010333
99RUNX1_22412390_ChIP-Seq_EML_Mouse0.99407792
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98652276
101KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97571954
102ATF3_27146783_Chip-Seq_COLON_Human0.96973482
103MYB_26560356_Chip-Seq_TH1_Human0.96733902
104* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96400298
105MAF_26560356_Chip-Seq_TH1_Human0.95892802
106* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95718626
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95291619
108* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95046006
109* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93307364
110MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93005071
111* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90305714
112MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.89109671
113UTX_26944678_Chip-Seq_JUKART_Human0.88835557
114GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88303038
115ELK1_22589737_ChIP-Seq_MCF10A_Human0.87108517
116MAF_26560356_Chip-Seq_TH2_Human0.87073652
117BRD4_27068464_Chip-Seq_AML-cells_Mouse0.86403268
118POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85021812

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.45214616
2MP0003111_abnormal_nucleus_morphology3.53300104
3MP0004957_abnormal_blastocyst_morpholog3.15661974
4MP0005451_abnormal_body_composition3.09518103
5MP0010094_abnormal_chromosome_stability3.08526263
6MP0003077_abnormal_cell_cycle3.01542834
7MP0001835_abnormal_antigen_presentation2.93902320
8MP0008058_abnormal_DNA_repair2.70530164
9MP0002396_abnormal_hematopoietic_system2.57992205
10MP0000685_abnormal_immune_system2.41191008
11MP0008057_abnormal_DNA_replication2.37741545
12MP0008007_abnormal_cellular_replicative2.29600375
13MP0009785_altered_susceptibility_to2.25322607
14MP0003191_abnormal_cellular_cholesterol2.16430558
15MP0005671_abnormal_response_to2.14835854
16MP0009333_abnormal_splenocyte_physiolog2.07827524
17MP0005397_hematopoietic_system_phenotyp2.01187494
18MP0001545_abnormal_hematopoietic_system2.01187494
19MP0003436_decreased_susceptibility_to1.89434310
20MP0002877_abnormal_melanocyte_morpholog1.87652301
21MP0010234_abnormal_vibrissa_follicle1.84760105
22MP0000490_abnormal_crypts_of1.81822816
23MP0002398_abnormal_bone_marrow1.81625160
24MP0005025_abnormal_response_to1.81157832
25MP0003763_abnormal_thymus_physiology1.79318108
26MP0001800_abnormal_humoral_immune1.78885651
27MP0002452_abnormal_antigen_presenting1.73423861
28MP0003806_abnormal_nucleotide_metabolis1.68771946
29MP0002148_abnormal_hypersensitivity_rea1.68182336
30MP0005410_abnormal_fertilization1.67698750
31MP0001853_heart_inflammation1.66963892
32MP0008932_abnormal_embryonic_tissue1.66672078
33MP0002723_abnormal_immune_serum1.64445994
34MP0001819_abnormal_immune_cell1.64333713
35MP0002420_abnormal_adaptive_immunity1.63418044
36MP0005000_abnormal_immune_tolerance1.62455638
37MP0003186_abnormal_redox_activity1.62429518
38MP0000689_abnormal_spleen_morphology1.62360040
39MP0002722_abnormal_immune_system1.61149114
40MP0003786_premature_aging1.60748927
41MP0000858_altered_metastatic_potential1.58430316
42MP0002653_abnormal_ependyma_morphology1.56224894
43MP0001730_embryonic_growth_arrest1.55561703
44MP0003656_abnormal_erythrocyte_physiolo1.55493270
45MP0001849_ear_inflammation1.54186811
46MP0000716_abnormal_immune_system1.53514338
47MP0002419_abnormal_innate_immunity1.53400275
48MP0008877_abnormal_DNA_methylation1.52645030
49MP0002405_respiratory_system_inflammati1.51906202
50MP0002429_abnormal_blood_cell1.51899222
51MP0002019_abnormal_tumor_incidence1.50028440
52MP0005501_abnormal_skin_physiology1.47758440
53MP0000350_abnormal_cell_proliferation1.46209519
54MP0004808_abnormal_hematopoietic_stem1.45132716
55MP0005464_abnormal_platelet_physiology1.43456669
56MP0003453_abnormal_keratinocyte_physiol1.43271080
57MP0005387_immune_system_phenotype1.42651045
58MP0001790_abnormal_immune_system1.42651045
59MP0002796_impaired_skin_barrier1.42041776
60MP0002254_reproductive_system_inflammat1.41845728
61MP0010307_abnormal_tumor_latency1.41185539
62MP0006035_abnormal_mitochondrial_morpho1.39874112
63MP0009840_abnormal_foam_cell1.38728878
64MP0000313_abnormal_cell_death1.37081968
65MP0001873_stomach_inflammation1.36515138
66MP0003075_altered_response_to1.27836466
67MP0000703_abnormal_thymus_morphology1.27738237
68MP0002132_abnormal_respiratory_system1.27485507
69MP0003718_maternal_effect1.27246251
70MP0006082_CNS_inflammation1.25168599
71MP0009764_decreased_sensitivity_to1.24110869
72MP0003303_peritoneal_inflammation1.23959147
73MP0010155_abnormal_intestine_physiology1.23060074
74MP0003172_abnormal_lysosome_physiology1.22165549
75MP0010352_gastrointestinal_tract_polyps1.21870358
76MP0001845_abnormal_inflammatory_respons1.19415697
77MP0001216_abnormal_epidermal_layer1.16712345
78MP0005075_abnormal_melanosome_morpholog1.16551102
79MP0001929_abnormal_gametogenesis1.14206014
80MP0005165_increased_susceptibility_to1.13302018
81MP0000465_gastrointestinal_hemorrhage1.09238781
82MP0003566_abnormal_cell_adhesion1.06639550
83MP0002080_prenatal_lethality1.06521052
84MP0003724_increased_susceptibility_to1.06462592
85MP0003705_abnormal_hypodermis_morpholog1.05226220
86MP0006054_spinal_hemorrhage1.04081035
87MP0008469_abnormal_protein_level1.03205227
88MP0001727_abnormal_embryo_implantation1.02308331
89MP0009278_abnormal_bone_marrow1.01104546
90MP0001697_abnormal_embryo_size1.00595746
91MP0002210_abnormal_sex_determination1.00055786
92MP0003866_abnormal_defecation0.99126390
93MP0005319_abnormal_enzyme/_coenzyme0.98501868
94MP0005380_embryogenesis_phenotype0.98296629
95MP0001672_abnormal_embryogenesis/_devel0.98296629
96MP0002166_altered_tumor_susceptibility0.95617301
97MP0005058_abnormal_lysosome_morphology0.95172422
98MP0001764_abnormal_homeostasis0.94757813
99MP0008789_abnormal_olfactory_epithelium0.94025800
100MP0002060_abnormal_skin_morphology0.92478951
101MP0003984_embryonic_growth_retardation0.91639151
102MP0003300_gastrointestinal_ulcer0.90842156
103MP0002006_tumorigenesis0.90060951
104MP0004947_skin_inflammation0.89673968
105MP0002088_abnormal_embryonic_growth/wei0.88666130
106MP0001533_abnormal_skeleton_physiology0.88555769
107MP0003448_altered_tumor_morphology0.88548387
108MP0005408_hypopigmentation0.87962259
109MP0004147_increased_porphyrin_level0.86920749
110MP0002160_abnormal_reproductive_system0.86442776
111MP0004381_abnormal_hair_follicle0.86093695
112MP0001145_abnormal_male_reproductive0.85937378
113MP0000358_abnormal_cell_content/0.85878425
114MP0000343_altered_response_to0.85101434
115MP0003950_abnormal_plasma_membrane0.84553773
116MP0001243_abnormal_dermal_layer0.82318336
117MP0005384_cellular_phenotype0.80903933
118MP0004233_abnormal_muscle_weight0.80359371
119MP0008260_abnormal_autophagy0.79939299
120MP0005621_abnormal_cell_physiology0.79549990
121MP0006036_abnormal_mitochondrial_physio0.78723131
122MP0000015_abnormal_ear_pigmentation0.78238149
123MP0005023_abnormal_wound_healing0.77604256
124MP0005584_abnormal_enzyme/coenzyme_acti0.76618449
125MP0000609_abnormal_liver_physiology0.76593214
126MP0002086_abnormal_extraembryonic_tissu0.72060589
127MP0005310_abnormal_salivary_gland0.70923005
128MP0000598_abnormal_liver_morphology0.68938188
129MP0000653_abnormal_sex_gland0.68358407
130MP0003698_abnormal_male_reproductive0.68281040
131MP0001542_abnormal_bone_strength0.66941066

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of anterior horn cells (HP:0002398)3.92879102
2Abnormality of the anterior horn cell (HP:0006802)3.92879102
3Abnormal number of erythroid precursors (HP:0012131)3.82476418
4Abnormality of cells of the erythroid lineage (HP:0012130)3.73350401
5Abnormality of glycolipid metabolism (HP:0010969)3.58111431
6Abnormality of liposaccharide metabolism (HP:0010968)3.58111431
7Abnormality of glycosphingolipid metabolism (HP:0004343)3.58111431
8Recurrent abscess formation (HP:0002722)3.50770535
9Thrombocytosis (HP:0001894)3.45557570
10Elevated erythrocyte sedimentation rate (HP:0003565)3.37594188
11Cerebral hypomyelination (HP:0006808)3.32171283
12Nasal polyposis (HP:0100582)3.31431969
13Abnormal mitochondria in muscle tissue (HP:0008316)3.31352864
14Microvesicular hepatic steatosis (HP:0001414)3.31077674
15Acute necrotizing encephalopathy (HP:0006965)3.24435632
16Oral leukoplakia (HP:0002745)3.22773441
17Aplastic anemia (HP:0001915)3.20382073
18Birth length less than 3rd percentile (HP:0003561)3.20112873
19Agnosia (HP:0010524)3.17210911
20Recurrent bacterial skin infections (HP:0005406)3.16388779
21Hepatocellular necrosis (HP:0001404)3.15883450
22Increased cerebral lipofuscin (HP:0011813)3.04268102
23Rough bone trabeculation (HP:0100670)3.01946350
24Petechiae (HP:0000967)3.00357995
25Mitochondrial inheritance (HP:0001427)3.00265256
26Increased CSF lactate (HP:0002490)2.95580533
27Tongue fasciculations (HP:0001308)2.84024049
28Reticulocytopenia (HP:0001896)2.82632483
29IgM deficiency (HP:0002850)2.82588019
30Acute encephalopathy (HP:0006846)2.82532800
31Increased neuronal autofluorescent lipopigment (HP:0002074)2.81816944
32Ragged-red muscle fibers (HP:0003200)2.79719607
33Abnormality of the nasal mucosa (HP:0000433)2.77995115
34Cholecystitis (HP:0001082)2.76318805
35Abnormal gallbladder physiology (HP:0012438)2.76318805
36Vacuolated lymphocytes (HP:0001922)2.76139021
37Carpal bone hypoplasia (HP:0001498)2.70867736
38Vertebral compression fractures (HP:0002953)2.70180915
39Multiple enchondromatosis (HP:0005701)2.68333594
40Hepatic necrosis (HP:0002605)2.63606721
41Personality changes (HP:0000751)2.61489374
42Pustule (HP:0200039)2.58978933
43Testicular atrophy (HP:0000029)2.58766649
44Loss of speech (HP:0002371)2.58318946
45Poor head control (HP:0002421)2.56009949
46Recurrent bronchitis (HP:0002837)2.55167257
47Chronic otitis media (HP:0000389)2.54176798
48Myositis (HP:0100614)2.53622402
49Hepatosplenomegaly (HP:0001433)2.53570777
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.52904967
51Hypokinesia (HP:0002375)2.52768717
52Muscle fibrillation (HP:0010546)2.52749065
53Eczematoid dermatitis (HP:0000976)2.51131272
54Breast hypoplasia (HP:0003187)2.46694414
55Abnormality of T cell physiology (HP:0011840)2.42317457
56Secondary amenorrhea (HP:0000869)2.42196461
57Progressive macrocephaly (HP:0004481)2.41677854
58Abnormal spermatogenesis (HP:0008669)2.38346730
59Lactic acidosis (HP:0003128)2.38181307
60Atrophy/Degeneration involving motor neurons (HP:0007373)2.37447278
61Hypertensive crisis (HP:0100735)2.36464628
62Microretrognathia (HP:0000308)2.35629857
63Increased intramyocellular lipid droplets (HP:0012240)2.35407103
64Premature ovarian failure (HP:0008209)2.35133081
65Trismus (HP:0000211)2.34486987
66Prolonged neonatal jaundice (HP:0006579)2.34319846
67Selective tooth agenesis (HP:0001592)2.33938581
68Increased serum lactate (HP:0002151)2.33702628
69Progressive muscle weakness (HP:0003323)2.28492069
70Spastic diplegia (HP:0001264)2.27874295
71Progressive neurologic deterioration (HP:0002344)2.27550606
72Abnormality of macrophages (HP:0004311)2.27406379
73Respiratory failure (HP:0002878)2.27140709
74Cerebral edema (HP:0002181)2.27119802
75Impulsivity (HP:0100710)2.24944491
76Bone marrow hypocellularity (HP:0005528)2.22022040
77Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.20894869
78Hypoplasia of the capital femoral epiphysis (HP:0003090)2.20353062
79Increased muscle lipid content (HP:0009058)2.19260568
80Premature graying of hair (HP:0002216)2.17827043
81Reduced antithrombin III activity (HP:0001976)2.17478632
82Lymphoma (HP:0002665)2.17414798
83Myelodysplasia (HP:0002863)2.16947020
84Muscle fiber atrophy (HP:0100295)2.16761257
85Progressive external ophthalmoplegia (HP:0000590)2.16660871
86Exercise intolerance (HP:0003546)2.15648905
87Exertional dyspnea (HP:0002875)2.15356408
88Increased serum ferritin (HP:0003281)2.15332828
89Cellular immunodeficiency (HP:0005374)2.14829110
90Type I transferrin isoform profile (HP:0003642)2.14491379
91Distal lower limb muscle weakness (HP:0009053)2.13647290
92Obstructive lung disease (HP:0006536)2.12838671
93Chronic obstructive pulmonary disease (HP:0006510)2.12838671
94Abnormality of T cells (HP:0002843)2.12288976
95Abnormal trabecular bone morphology (HP:0100671)2.11849464
96Cleft eyelid (HP:0000625)2.10542286
97Type 2 muscle fiber atrophy (HP:0003554)2.09384283
98Irregular epiphyses (HP:0010582)2.08943266
99Aplasia/Hypoplasia of the sacrum (HP:0008517)2.08303739
100Mediastinal lymphadenopathy (HP:0100721)2.06995834
101Pulmonary fibrosis (HP:0002206)2.04042705
102Amaurosis fugax (HP:0100576)2.03688166
103Respiratory difficulties (HP:0002880)2.03564175
104Poikiloderma (HP:0001029)2.03017280
10511 pairs of ribs (HP:0000878)2.02438638
106Reduced subcutaneous adipose tissue (HP:0003758)2.01933736
107Recurrent fungal infections (HP:0002841)2.01388849
108Recurrent viral infections (HP:0004429)2.01074868
109Patellar aplasia (HP:0006443)2.00755950
110Upper motor neuron abnormality (HP:0002127)2.00591199
111IgG deficiency (HP:0004315)2.00403390
112Recurrent gram-negative bacterial infections (HP:0005420)1.98004253
113Death in infancy (HP:0001522)1.97969514
114Macrocytic anemia (HP:0001972)1.96629297
115Abnormality of glycolysis (HP:0004366)1.96221245
116Pancytopenia (HP:0001876)1.95936876
117Entropion (HP:0000621)1.95644289
118Micronodular cirrhosis (HP:0001413)1.94688884
119Pallor (HP:0000980)1.94507211
120Increased hepatocellular lipid droplets (HP:0006565)1.94229079
121Bronchitis (HP:0012387)1.94175194
122Aplasia/Hypoplasia of the patella (HP:0006498)1.92651755
123Combined immunodeficiency (HP:0005387)1.91151941
124Abnormality of the umbilical cord (HP:0010881)1.90473194
125Aseptic necrosis (HP:0010885)1.88930148
126Renal Fanconi syndrome (HP:0001994)1.88433225
127Abnormalities of placenta or umbilical cord (HP:0001194)1.86575514
128Congenital ichthyosiform erythroderma (HP:0007431)1.85953671
129Increased serum pyruvate (HP:0003542)1.84908454
130Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.84182765
131Abnormal protein N-linked glycosylation (HP:0012347)1.84182765
132Abnormal protein glycosylation (HP:0012346)1.84182765
133Abnormal glycosylation (HP:0012345)1.84182765
134Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.83652251
135Absent epiphyses (HP:0010577)1.83652251
136Dysostosis multiplex (HP:0000943)1.83445607
137Lipid accumulation in hepatocytes (HP:0006561)1.81595419
138Recurrent skin infections (HP:0001581)1.81346805
139Orchitis (HP:0100796)1.80583369
140Squamous cell carcinoma (HP:0002860)1.80160708
141Abnormality of the preputium (HP:0100587)1.79940755
142Achilles tendon contracture (HP:0001771)1.79328973
143Autoimmune thrombocytopenia (HP:0001973)1.78577875
144Sparse eyelashes (HP:0000653)1.78143804
145Anorexia (HP:0002039)1.77958401
146Decreased activity of mitochondrial respiratory chain (HP:0008972)1.77933893
147Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.77933893
148Abnormality of the motor neurons (HP:0002450)1.77554517
149Abnormal neuron morphology (HP:0012757)1.77554517
150Fasciculations (HP:0002380)1.77511709
151Abnormality of the distal phalanges of the toes (HP:0010182)1.77118932
152Abnormality of pyrimidine metabolism (HP:0004353)1.77004528
153Retrobulbar optic neuritis (HP:0100654)1.75121337
154Optic neuritis (HP:0100653)1.75121337
155Gastrointestinal infarctions (HP:0005244)1.75092937
156Granulocytopenia (HP:0001913)1.73695991
157Nail dystrophy (HP:0008404)1.72928066
158Increased IgM level (HP:0003496)1.71882573
159Prostate neoplasm (HP:0100787)1.71834540
160Increased connective tissue (HP:0009025)1.71482587
161Spinal muscular atrophy (HP:0007269)1.71444877
162Abnormality of cells of the lymphoid lineage (HP:0012140)1.70919332
163Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.70620079
164Absent thumb (HP:0009777)1.69029776
165Meckel diverticulum (HP:0002245)1.68841742
166Meningitis (HP:0001287)1.68809373
167Opisthotonus (HP:0002179)1.68313738
168Generalized amyotrophy (HP:0003700)1.67257611
169Autoimmune hemolytic anemia (HP:0001890)1.64851629
170Amniotic constriction ring (HP:0009775)1.64006783
171Abnormality of placental membranes (HP:0011409)1.64006783

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.88467383
2VRK23.54165614
3EIF2AK13.36111207
4WEE12.79902835
5MAP4K12.61429091
6PIM22.60633274
7NME22.56326906
8NEK22.30212318
9SMG12.17344541
10TESK12.01614276
11BLK1.99570182
12TESK21.99535065
13STK161.99436824
14CDC71.92423583
15EIF2AK31.90035128
16PLK41.87715941
17CCNB11.69845143
18SRPK11.68786231
19MAP2K31.61539906
20TBK11.59566058
21NEK11.55335244
22IRAK41.52199775
23RPS6KA41.51667736
24TSSK61.49573602
25STK101.47633798
26TRIB31.46196069
27LIMK11.42823103
28BRSK21.41858595
29PLK11.41198094
30MST1R1.38907369
31TTK1.38097335
32IRAK31.35016309
33TXK1.34939782
34DYRK31.33596226
35ZAP701.32815772
36ABL21.32638615
37ACVR1B1.30306752
38PIM11.27077635
39VRK11.26961367
40JAK31.22051944
41MAP3K111.22026748
42BRSK11.20199550
43AURKB1.16936965
44PAK41.15636727
45TLK11.13527861
46RPS6KB21.10217025
47KIT1.09405809
48MAP3K121.07589651
49MAP3K81.07577154
50KDR1.07358020
51ATR1.04945181
52TYK21.00811232
53CDK71.00602490
54IKBKB0.99633631
55ARAF0.98989616
56AURKA0.97879645
57CDK40.96081148
58TRIM280.93878655
59BTK0.92968901
60PDK30.92789530
61PDK40.92789530
62EPHA20.91583438
63PRPF4B0.90955636
64EEF2K0.86734375
65SIK10.85980098
66IRAK20.85817305
67GRK60.84945174
68IKBKE0.82286560
69MAPKAPK30.80848075
70FLT30.80355736
71LRRK20.80318014
72ILK0.78406297
73MST40.77921283
74CSF1R0.77895933
75EIF2AK20.76539505
76PASK0.76377587
77BRAF0.75393498
78PLK30.75285621
79MAP3K10.73622219
80CHEK20.73291307
81TEC0.70638077
82MAP3K140.69949644
83ERN10.69105747
84MAP3K30.67846880
85CDK80.67463239
86BCKDK0.65916271
87SYK0.64416913
88PBK0.64128793
89PAK10.63987885
90MAP2K60.63476081
91CHEK10.63335742
92STK40.61310975
93SCYL20.60463715
94LMTK20.58289515
95MKNK10.56490221
96CSNK2A10.55092858
97PTK60.53829864
98SIK30.53249551
99MAP2K70.52375081
100LYN0.52368766
101CHUK0.52321567
102ZAK0.51353201
103MARK30.51086622
104PRKCI0.50563141
105PDK20.50434410
106TGFBR10.49509215
107TAOK20.49491150
108DAPK10.49092038
109TAOK10.48368864
110DAPK30.47050898
111CSNK2A20.46792703
112NME10.45098288
113EPHB10.44824458
114RAF10.41153990
115MAPKAPK20.40512630
116RIPK40.39078492
117MATK0.38035524
118STK240.37711611
119PRKD20.36210801
120CSNK1G30.36070526
121ICK0.36014329
122CDK60.35733946
123CDK90.35669139
124MOS0.35638569
125CSK0.31990808
126TGFBR20.31830115
127MAP3K50.31355251

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.16878040
2Proteasome_Homo sapiens_hsa030503.96424365
3Mismatch repair_Homo sapiens_hsa034303.33823511
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.02010513
5RNA polymerase_Homo sapiens_hsa030202.99751959
6Base excision repair_Homo sapiens_hsa034102.98637513
7Ribosome_Homo sapiens_hsa030102.96771129
8Spliceosome_Homo sapiens_hsa030402.53351247
9Homologous recombination_Homo sapiens_hsa034402.45547110
10RNA transport_Homo sapiens_hsa030132.43742449
11Pyrimidine metabolism_Homo sapiens_hsa002402.41654212
12Nucleotide excision repair_Homo sapiens_hsa034202.25048505
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.98518879
14Cell cycle_Homo sapiens_hsa041101.96251991
15Oxidative phosphorylation_Homo sapiens_hsa001901.78365804
16One carbon pool by folate_Homo sapiens_hsa006701.72398858
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.65277737
18Basal transcription factors_Homo sapiens_hsa030221.64265210
19Pentose phosphate pathway_Homo sapiens_hsa000301.60666826
20Antigen processing and presentation_Homo sapiens_hsa046121.59099716
21Sulfur metabolism_Homo sapiens_hsa009201.57084284
22Vitamin B6 metabolism_Homo sapiens_hsa007501.54772413
23Parkinsons disease_Homo sapiens_hsa050121.50381158
24p53 signaling pathway_Homo sapiens_hsa041151.48851844
25Non-homologous end-joining_Homo sapiens_hsa034501.48517111
26Sulfur relay system_Homo sapiens_hsa041221.44837383
27Fanconi anemia pathway_Homo sapiens_hsa034601.44524133
28RNA degradation_Homo sapiens_hsa030181.41244484
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.40975003
30Epstein-Barr virus infection_Homo sapiens_hsa051691.35749555
31Folate biosynthesis_Homo sapiens_hsa007901.32898218
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.32023261
33Purine metabolism_Homo sapiens_hsa002301.28487527
34Primary immunodeficiency_Homo sapiens_hsa053401.27952662
35Fatty acid elongation_Homo sapiens_hsa000621.24905758
36Legionellosis_Homo sapiens_hsa051341.21830980
37Herpes simplex infection_Homo sapiens_hsa051681.19250115
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14063715
39Vibrio cholerae infection_Homo sapiens_hsa051101.07655549
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.05438773
41Leishmaniasis_Homo sapiens_hsa051401.02531008
42Measles_Homo sapiens_hsa051621.01477979
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.00125437
44NF-kappa B signaling pathway_Homo sapiens_hsa040640.92684524
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90561797
46Biosynthesis of amino acids_Homo sapiens_hsa012300.89924114
47Shigellosis_Homo sapiens_hsa051310.88649666
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88493086
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86320542
50Apoptosis_Homo sapiens_hsa042100.86238007
51mRNA surveillance pathway_Homo sapiens_hsa030150.86163608
52Selenocompound metabolism_Homo sapiens_hsa004500.85376711
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84446157
54Alzheimers disease_Homo sapiens_hsa050100.84241084
55Salmonella infection_Homo sapiens_hsa051320.81370989
56Influenza A_Homo sapiens_hsa051640.78228069
57Bladder cancer_Homo sapiens_hsa052190.78193281
58Glutathione metabolism_Homo sapiens_hsa004800.77077960
59Fructose and mannose metabolism_Homo sapiens_hsa000510.76152718
60Viral carcinogenesis_Homo sapiens_hsa052030.74554163
61Allograft rejection_Homo sapiens_hsa053300.73128214
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69299380
63Protein export_Homo sapiens_hsa030600.67052696
64Other glycan degradation_Homo sapiens_hsa005110.66145475
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65193046
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61642236
67Caffeine metabolism_Homo sapiens_hsa002320.60998219
68Galactose metabolism_Homo sapiens_hsa000520.60207269
69Hematopoietic cell lineage_Homo sapiens_hsa046400.59269213
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59095126
71Carbon metabolism_Homo sapiens_hsa012000.59087993
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58339266
73HTLV-I infection_Homo sapiens_hsa051660.58046785
74N-Glycan biosynthesis_Homo sapiens_hsa005100.57344771
75Collecting duct acid secretion_Homo sapiens_hsa049660.56569470
76Phagosome_Homo sapiens_hsa041450.56532989
77Rheumatoid arthritis_Homo sapiens_hsa053230.55539363
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54219001
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54160856
80Graft-versus-host disease_Homo sapiens_hsa053320.53926520
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52275084
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51067401
83TNF signaling pathway_Homo sapiens_hsa046680.50818833
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49251379
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49152690
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48929138
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48233454
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.48175599
89Pertussis_Homo sapiens_hsa051330.48108370
90Hepatitis C_Homo sapiens_hsa051600.47955995
91Oocyte meiosis_Homo sapiens_hsa041140.47783683
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47047382
93Pyruvate metabolism_Homo sapiens_hsa006200.46866423
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45950132
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45345320
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45046840
97Asthma_Homo sapiens_hsa053100.44443135
98Tuberculosis_Homo sapiens_hsa051520.44420253
99B cell receptor signaling pathway_Homo sapiens_hsa046620.44318106
100Huntingtons disease_Homo sapiens_hsa050160.44131711
101Regulation of autophagy_Homo sapiens_hsa041400.42703232
102Systemic lupus erythematosus_Homo sapiens_hsa053220.42069731
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.41997653
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41914674
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41638381
106Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41428881
107Hepatitis B_Homo sapiens_hsa051610.41279411
108Lysosome_Homo sapiens_hsa041420.40104593
109Toxoplasmosis_Homo sapiens_hsa051450.37251235
110Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35518073
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35094437
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.33106891
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32362874
114Acute myeloid leukemia_Homo sapiens_hsa052210.31660642
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.31547192
116Metabolic pathways_Homo sapiens_hsa011000.31188008
117Staphylococcus aureus infection_Homo sapiens_hsa051500.29555015
118Osteoclast differentiation_Homo sapiens_hsa043800.29358633
119Thyroid cancer_Homo sapiens_hsa052160.26705906
120Notch signaling pathway_Homo sapiens_hsa043300.26128916
121Small cell lung cancer_Homo sapiens_hsa052220.25972518
122Renin-angiotensin system_Homo sapiens_hsa046140.25838995
123Vitamin digestion and absorption_Homo sapiens_hsa049770.25032815

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