BRMS1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene shows sequence similarity to the human breast carcinoma metastasis suppressor (BRMS1) protein and the mammalian Sds3 (suppressor of defective silencing 3) proteins. This protein is a component of the mSin3a family of histone deacetylase complexes (HDAC). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.36496399
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.34911081
3synaptic vesicle maturation (GO:0016188)4.96304933
4synaptic vesicle docking involved in exocytosis (GO:0016081)4.95757261
5vocalization behavior (GO:0071625)4.82358778
6regulation of synaptic vesicle exocytosis (GO:2000300)4.79647754
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.77557580
8protein localization to synapse (GO:0035418)4.68906771
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.65985032
10glutamate secretion (GO:0014047)4.65007089
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.51957701
12locomotory exploration behavior (GO:0035641)4.46149366
13neuronal action potential propagation (GO:0019227)4.35828682
14regulation of synaptic vesicle transport (GO:1902803)4.24438480
15neuron cell-cell adhesion (GO:0007158)4.11063504
16regulation of glutamate receptor signaling pathway (GO:1900449)4.10659467
17neurotransmitter secretion (GO:0007269)4.00417214
18positive regulation of synapse maturation (GO:0090129)3.86555916
19exploration behavior (GO:0035640)3.84575810
20regulation of long-term neuronal synaptic plasticity (GO:0048169)3.83211996
21regulation of neuronal synaptic plasticity (GO:0048168)3.76771891
22neurotransmitter-gated ion channel clustering (GO:0072578)3.74426020
23ionotropic glutamate receptor signaling pathway (GO:0035235)3.74026717
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.72861039
25membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.69170521
26regulation of synapse structural plasticity (GO:0051823)3.61889281
27neuron-neuron synaptic transmission (GO:0007270)3.58853241
28synaptic transmission, glutamatergic (GO:0035249)3.57898792
29glutamate receptor signaling pathway (GO:0007215)3.52311816
30chromatin remodeling at centromere (GO:0031055)3.51170916
31cerebellar granule cell differentiation (GO:0021707)3.49141915
32CENP-A containing nucleosome assembly (GO:0034080)3.39624119
33positive regulation of membrane potential (GO:0045838)3.38808753
34regulation of excitatory postsynaptic membrane potential (GO:0060079)3.36773896
35DNA damage response, detection of DNA damage (GO:0042769)3.35829256
36layer formation in cerebral cortex (GO:0021819)3.34109522
37neuron recognition (GO:0008038)3.31671310
38regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.31451790
39long-term synaptic potentiation (GO:0060291)3.31444521
40positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.30419227
41gamma-aminobutyric acid signaling pathway (GO:0007214)3.28382406
42negative regulation of synaptic transmission, GABAergic (GO:0032229)3.24897622
43kinetochore assembly (GO:0051382)3.24809167
44regulation of postsynaptic membrane potential (GO:0060078)3.21059139
45presynaptic membrane assembly (GO:0097105)3.20064431
46axonal fasciculation (GO:0007413)3.18519907
47kinetochore organization (GO:0051383)3.18182892
48neurotransmitter transport (GO:0006836)3.17981973
49regulation of synaptic transmission, glutamatergic (GO:0051966)3.17109789
50cullin deneddylation (GO:0010388)3.16698962
51regulation of synaptic plasticity (GO:0048167)3.15591229
52auditory behavior (GO:0031223)3.15562370
53innervation (GO:0060384)3.14968196
54regulation of dendritic spine morphogenesis (GO:0061001)3.14353363
55long-term memory (GO:0007616)3.12742607
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.11670345
57proline transport (GO:0015824)3.11089146
58regulation of neurotransmitter secretion (GO:0046928)3.10933315
59postsynaptic membrane organization (GO:0001941)3.09345061
60positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.09332822
61cell migration in hindbrain (GO:0021535)3.07160234
62synaptic vesicle endocytosis (GO:0048488)3.06135117
63behavioral defense response (GO:0002209)3.05155312
64behavioral fear response (GO:0001662)3.05155312
65dendritic spine morphogenesis (GO:0060997)3.02444984
66presynaptic membrane organization (GO:0097090)2.99940854
67replication fork processing (GO:0031297)2.99919405
68mechanosensory behavior (GO:0007638)2.99345306
69pyrimidine nucleobase catabolic process (GO:0006208)2.99236532
70cellular potassium ion homeostasis (GO:0030007)2.98836166
71histone exchange (GO:0043486)2.98773842
72membrane depolarization during action potential (GO:0086010)2.98577217
73transmission of nerve impulse (GO:0019226)2.94807794
74neuromuscular process controlling posture (GO:0050884)2.94644654
75negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.94472712
76DNA replication-independent nucleosome assembly (GO:0006336)2.92578732
77DNA replication-independent nucleosome organization (GO:0034724)2.92578732
78regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.92221705
79neuromuscular process controlling balance (GO:0050885)2.92111170
80regulation of neurotransmitter transport (GO:0051588)2.91132529
81negative regulation of microtubule polymerization (GO:0031115)2.90807977
82negative regulation of DNA-dependent DNA replication (GO:2000104)2.90195763
83G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.89565199
84proteasome assembly (GO:0043248)2.88807090
85regulation of neurotransmitter levels (GO:0001505)2.88453666
86positive regulation of dendritic spine morphogenesis (GO:0061003)2.87286546
87activation of protein kinase A activity (GO:0034199)2.87077586
88regulation of vesicle fusion (GO:0031338)2.86821003
89negative regulation of dendrite morphogenesis (GO:0050774)2.86632201
90positive regulation of neurotransmitter transport (GO:0051590)2.86302180
91cerebellar Purkinje cell differentiation (GO:0021702)2.86002488
92mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.84759068
93fear response (GO:0042596)2.84411508
94regulation of synapse maturation (GO:0090128)2.84040067
95membrane depolarization (GO:0051899)2.83474747
96mitotic metaphase plate congression (GO:0007080)2.83208109
97learning (GO:0007612)2.81317536
98protein deneddylation (GO:0000338)2.80921690
99regulation of nuclear cell cycle DNA replication (GO:0033262)2.80919213
100positive regulation of synaptic transmission (GO:0050806)2.80284913
101neuromuscular process (GO:0050905)2.79759427
102regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.79127628
103positive regulation of synapse assembly (GO:0051965)2.78862932
104vesicle transport along microtubule (GO:0047496)2.78328184
105DNA double-strand break processing (GO:0000729)2.77590370
106striatum development (GO:0021756)2.77424569
107positive regulation of neurotransmitter secretion (GO:0001956)2.77248741
108protein localization to kinetochore (GO:0034501)2.75076923
109synapse assembly (GO:0007416)2.74757360
110synaptic transmission (GO:0007268)2.73958556
111limb bud formation (GO:0060174)2.73543886
112regulation of voltage-gated calcium channel activity (GO:1901385)2.71960956
113regulation of synaptic transmission (GO:0050804)2.69430406
114establishment of protein localization to mitochondrial membrane (GO:0090151)2.69313001
115positive regulation of synaptic transmission, GABAergic (GO:0032230)2.69136644
116histone H2A acetylation (GO:0043968)2.68453926
117startle response (GO:0001964)2.68293044
118membrane hyperpolarization (GO:0060081)2.67697498
119synapse organization (GO:0050808)2.67611157
120DNA replication checkpoint (GO:0000076)2.67565417
121positive regulation of potassium ion transmembrane transport (GO:1901381)2.66339803
122maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.66240366
123ubiquinone metabolic process (GO:0006743)2.65230113
124nonmotile primary cilium assembly (GO:0035058)2.64865067
125regulation of protein kinase A signaling (GO:0010738)2.64843163
126response to auditory stimulus (GO:0010996)2.63266768
127protein-cofactor linkage (GO:0018065)2.61452389
128postreplication repair (GO:0006301)2.59259233
129somatic diversification of immune receptors via somatic mutation (GO:0002566)2.54760226
130somatic hypermutation of immunoglobulin genes (GO:0016446)2.54760226
131respiratory chain complex IV assembly (GO:0008535)2.54681561
132spindle checkpoint (GO:0031577)2.53668592
133chaperone-mediated protein transport (GO:0072321)2.49764552
134response to pheromone (GO:0019236)2.49147240
135ubiquinone biosynthetic process (GO:0006744)2.47057688
136establishment of integrated proviral latency (GO:0075713)2.46651508
137metaphase plate congression (GO:0051310)2.45239425
138regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.44173040
139regulation of mitotic spindle checkpoint (GO:1903504)2.44173040
140regulation of hexokinase activity (GO:1903299)2.42943871
141regulation of glucokinase activity (GO:0033131)2.42943871
142telomere maintenance via telomerase (GO:0007004)2.42232685
143regulation of mitochondrial translation (GO:0070129)2.39686136
144exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.39512474
145nucleotide-excision repair, DNA gap filling (GO:0006297)2.38942075
146mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.38419140
147regulation of helicase activity (GO:0051095)2.37892850
148L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.37219989
149protein localization to chromosome, centromeric region (GO:0071459)2.36057423
150mitotic spindle checkpoint (GO:0071174)2.35474887
151substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.35090679
152substrate-independent telencephalic tangential migration (GO:0021826)2.35090679
153cornea development in camera-type eye (GO:0061303)2.34573531
154nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.33847860
155C4-dicarboxylate transport (GO:0015740)2.33112145
156water-soluble vitamin biosynthetic process (GO:0042364)2.31105011
157single strand break repair (GO:0000012)2.29731917
158protein complex biogenesis (GO:0070271)2.29043440
159regulation of meiosis I (GO:0060631)2.27036799
160protein K6-linked ubiquitination (GO:0085020)2.26911842
161nucleobase catabolic process (GO:0046113)2.26319277
162mitochondrial respiratory chain complex assembly (GO:0033108)2.25544813
163sterol biosynthetic process (GO:0016126)2.25254111
164cholesterol biosynthetic process (GO:0006695)2.24594018
165negative regulation of mitotic sister chromatid separation (GO:2000816)2.22272948
166negative regulation of sister chromatid segregation (GO:0033046)2.22272948
167negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.22272948
168negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.22272948
169negative regulation of mitotic sister chromatid segregation (GO:0033048)2.22272948
170DNA replication-dependent nucleosome assembly (GO:0006335)2.22171280
171DNA replication-dependent nucleosome organization (GO:0034723)2.22171280
172mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.20780474
173mitotic sister chromatid segregation (GO:0000070)2.20525046
174acrosome assembly (GO:0001675)2.20043016
175protein localization to chromosome (GO:0034502)2.18321970
176negative regulation of chromosome segregation (GO:0051985)2.18203546
177organelle disassembly (GO:1903008)2.17978872
178regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.17608201
179resolution of meiotic recombination intermediates (GO:0000712)2.17186950
180olfactory bulb development (GO:0021772)2.17154894
181mitochondrial respiratory chain complex I assembly (GO:0032981)2.16487879
182NADH dehydrogenase complex assembly (GO:0010257)2.16487879
183mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.16487879
184regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.15979084
185regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.15782381
186regulation of mitotic metaphase/anaphase transition (GO:0030071)2.15782381
187protein neddylation (GO:0045116)2.15246258
188attachment of spindle microtubules to kinetochore (GO:0008608)2.14981761
189DNA ligation (GO:0006266)2.13858670
190branched-chain amino acid catabolic process (GO:0009083)2.13101106
191aspartate family amino acid catabolic process (GO:0009068)2.11731250
192sister chromatid segregation (GO:0000819)2.11560397
193regulation of chromosome segregation (GO:0051983)2.11540969

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.78263397
2GBX2_23144817_ChIP-Seq_PC3_Human3.73104478
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.20586625
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00673954
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.96866623
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.94837986
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.88079952
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.61055542
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.57299689
10REST_21632747_ChIP-Seq_MESCs_Mouse2.57086543
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.55464391
12* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.55464391
13RARB_27405468_Chip-Seq_BRAIN_Mouse2.49669973
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.48488712
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.46346418
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44001024
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.40556595
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.33865314
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.32468099
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.31296383
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.30821017
22E2F7_22180533_ChIP-Seq_HELA_Human2.30695162
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.28720249
24TAF15_26573619_Chip-Seq_HEK293_Human2.27616105
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.21830324
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20618142
27REST_18959480_ChIP-ChIP_MESCs_Mouse2.18490964
28VDR_22108803_ChIP-Seq_LS180_Human2.15754151
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15695375
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.15620321
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.11411592
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.07940005
33RNF2_27304074_Chip-Seq_ESCs_Mouse2.07564765
34CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01215176
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.98359585
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.90785034
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86715843
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.83261187
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83006918
40ZNF274_21170338_ChIP-Seq_K562_Hela1.79641143
41DROSHA_22980978_ChIP-Seq_HELA_Human1.78765030
42ELK1_19687146_ChIP-ChIP_HELA_Human1.78647365
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77936358
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77553707
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77394251
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.74938984
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74346791
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.73614534
49KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.68179688
50SMAD4_21799915_ChIP-Seq_A2780_Human1.66774250
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.64820537
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62685762
53* FUS_26573619_Chip-Seq_HEK293_Human1.60569115
54P300_19829295_ChIP-Seq_ESCs_Human1.60074374
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56622403
56AR_21572438_ChIP-Seq_LNCaP_Human1.54987179
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.52809265
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51133545
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51005972
60AR_21909140_ChIP-Seq_LNCAP_Human1.50406997
61* ETS1_20019798_ChIP-Seq_JURKAT_Human1.46111619
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45013592
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43421940
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43089185
65JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.42569345
66SMAD_19615063_ChIP-ChIP_OVARY_Human1.42143440
67MYC_18555785_ChIP-Seq_MESCs_Mouse1.41314582
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.40912004
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40512956
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.39275825
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38447470
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37827698
73IGF1R_20145208_ChIP-Seq_DFB_Human1.36997232
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36825041
75THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36392573
76MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36133196
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35533830
78* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35454014
79RNF2_27304074_Chip-Seq_NSC_Mouse1.32442030
80POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31600164
81EWS_26573619_Chip-Seq_HEK293_Human1.31483198
82* SMAD3_21741376_ChIP-Seq_EPCs_Human1.28143750
83EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27653864
84STAT3_23295773_ChIP-Seq_U87_Human1.27649787
85TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.26579057
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26069461
87* VDR_23849224_ChIP-Seq_CD4+_Human1.25276063
88AR_25329375_ChIP-Seq_VCAP_Human1.25230037
89MYC_18940864_ChIP-ChIP_HL60_Human1.22651876
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22099267
91JUN_21703547_ChIP-Seq_K562_Human1.19991219
92YAP1_20516196_ChIP-Seq_MESCs_Mouse1.19580484
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17407501
94RING1B_27294783_Chip-Seq_ESCs_Mouse1.16214017
95* AR_19668381_ChIP-Seq_PC3_Human1.15733659
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.15442892
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15210106
98WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14495422
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14060393
100HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13990641
101NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13839888
102SOX9_26525672_Chip-Seq_HEART_Mouse1.13226691
103* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12429421
104DCP1A_22483619_ChIP-Seq_HELA_Human1.11827721
105* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.11010523
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10446564
107ERG_21242973_ChIP-ChIP_JURKAT_Human1.10097115
108* ER_23166858_ChIP-Seq_MCF-7_Human1.10030838
109P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09716416
110SOX2_16153702_ChIP-ChIP_HESCs_Human1.09361968
111TCF4_23295773_ChIP-Seq_U87_Human1.08447850
112EZH2_27294783_Chip-Seq_NPCs_Mouse1.07904214
113* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07501445
114MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07371930
115TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07064253
116MYC_19030024_ChIP-ChIP_MESCs_Mouse1.06279720
117SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05703708
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05101457
119ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04843247
120KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04510673
121* RUNX2_22187159_ChIP-Seq_PCA_Human1.03218782
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03097682
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03097682
124NANOG_18555785_Chip-Seq_ESCs_Mouse1.02913158
125NANOG_16153702_ChIP-ChIP_HESCs_Human1.02646725
126CBP_20019798_ChIP-Seq_JUKART_Human1.02571982
127IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02571982
128KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01571189
129TTF2_22483619_ChIP-Seq_HELA_Human1.00818341
130TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00481728
131RING1B_27294783_Chip-Seq_NPCs_Mouse1.00002113
132GABP_19822575_ChIP-Seq_HepG2_Human0.99815270
133* E2F1_21310950_ChIP-Seq_MCF-7_Human0.99591731
134SMAD3_21741376_ChIP-Seq_ESCs_Human0.99527008
135UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98827072
136FOXP3_21729870_ChIP-Seq_TREG_Human0.98180087
137CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97895569
138SRF_21415370_ChIP-Seq_HL-1_Mouse0.96011693
139IRF1_19129219_ChIP-ChIP_H3396_Human0.95035695
140NFE2_27457419_Chip-Seq_LIVER_Mouse0.94520666
141PRDM14_20953172_ChIP-Seq_ESCs_Human0.93976839
142ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93141178
143CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93054693
144PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93003665
145TBX3_20139965_ChIP-Seq_ESCs_Mouse0.92885475
146FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92705951
147TBX3_20139965_ChIP-Seq_MESCs_Mouse0.92637365
148NELFA_20434984_ChIP-Seq_ESCs_Mouse0.92489798
149PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92160033
150DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92113388
151TP53_22573176_ChIP-Seq_HFKS_Human0.92108554
152MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91233323
153WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88961670
154TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88435599
155SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.87477614
156MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.85378730
157HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.85357619
158CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84495283
159NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84435483
160DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.81727481
161POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.79881377

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.28279108
2MP0003880_abnormal_central_pattern4.44674673
3MP0003635_abnormal_synaptic_transmissio3.59841715
4MP0004270_analgesia3.54961377
5MP0002063_abnormal_learning/memory/cond2.85772205
6MP0001968_abnormal_touch/_nociception2.82705289
7MP0002064_seizures2.80051578
8MP0009046_muscle_twitch2.79436334
9MP0009745_abnormal_behavioral_response2.78856238
10MP0002734_abnormal_mechanical_nocicepti2.61967015
11MP0002736_abnormal_nociception_after2.38562376
12MP0002572_abnormal_emotion/affect_behav2.38510904
13MP0003122_maternal_imprinting2.37075836
14MP0002735_abnormal_chemical_nociception2.35995600
15MP0002272_abnormal_nervous_system2.35862575
16MP0003787_abnormal_imprinting2.25021480
17MP0008058_abnormal_DNA_repair2.24996971
18MP0002822_catalepsy2.21346996
19MP0001486_abnormal_startle_reflex2.11525177
20MP0003123_paternal_imprinting2.07450423
21MP0003890_abnormal_embryonic-extraembry2.02376251
22MP0010094_abnormal_chromosome_stability2.01065137
23MP0006276_abnormal_autonomic_nervous1.96013295
24MP0002067_abnormal_sensory_capabilities1.89837074
25MP0002733_abnormal_thermal_nociception1.89819755
26MP0001970_abnormal_pain_threshold1.89582391
27MP0002184_abnormal_innervation1.86716857
28MP0006292_abnormal_olfactory_placode1.84678007
29MP0003693_abnormal_embryo_hatching1.81655431
30MP0001440_abnormal_grooming_behavior1.80124905
31MP0000778_abnormal_nervous_system1.77427997
32MP0005423_abnormal_somatic_nervous1.75575377
33MP0004858_abnormal_nervous_system1.74195015
34MP0006072_abnormal_retinal_apoptosis1.68678576
35MP0001501_abnormal_sleep_pattern1.68127422
36MP0008569_lethality_at_weaning1.64103309
37MP0004811_abnormal_neuron_physiology1.61570129
38MP0003111_abnormal_nucleus_morphology1.61346496
39MP0003121_genomic_imprinting1.60469989
40MP0003941_abnormal_skin_development1.58211972
41MP0008057_abnormal_DNA_replication1.57157871
42MP0001529_abnormal_vocalization1.54020099
43MP0002557_abnormal_social/conspecific_i1.53737101
44MP0008932_abnormal_embryonic_tissue1.53592612
45MP0001188_hyperpigmentation1.53275075
46MP0004924_abnormal_behavior1.52305193
47MP0005386_behavior/neurological_phenoty1.52305193
48MP0009780_abnormal_chondrocyte_physiolo1.50955685
49MP0000955_abnormal_spinal_cord1.50024696
50MP0002102_abnormal_ear_morphology1.50018915
51MP0003329_amyloid_beta_deposits1.49368652
52MP0001293_anophthalmia1.43496580
53MP0004145_abnormal_muscle_electrophysio1.40810151
54MP0009697_abnormal_copulation1.40151162
55MP0000751_myopathy1.38740781
56MP0002882_abnormal_neuron_morphology1.35942460
57MP0002938_white_spotting1.33128287
58MP0002066_abnormal_motor_capabilities/c1.30258451
59MP0004957_abnormal_blastocyst_morpholog1.27891546
60MP0005646_abnormal_pituitary_gland1.26410616
61MP0005253_abnormal_eye_physiology1.25830714
62MP0004233_abnormal_muscle_weight1.23292667
63MP0003077_abnormal_cell_cycle1.23241109
64MP0003937_abnormal_limbs/digits/tail_de1.21915914
65MP0006035_abnormal_mitochondrial_morpho1.21662253
66MP0004142_abnormal_muscle_tone1.19732656
67MP0001984_abnormal_olfaction1.19357468
68MP0003718_maternal_effect1.19260310
69MP0002233_abnormal_nose_morphology1.19003082
70MP0004215_abnormal_myocardial_fiber1.16631875
71MP0002909_abnormal_adrenal_gland1.14451337
72MP0001905_abnormal_dopamine_level1.14445031
73MP0002152_abnormal_brain_morphology1.14194533
74MP0000013_abnormal_adipose_tissue1.13432858
75MP0003567_abnormal_fetal_cardiomyocyte1.12859437
76MP0002090_abnormal_vision1.11446570
77MP0004133_heterotaxia1.11259191
78MP0000647_abnormal_sebaceous_gland1.11225159
79MP0003136_yellow_coat_color1.09345727
80MP0004885_abnormal_endolymph1.08749476
81MP0003119_abnormal_digestive_system1.05588983
82MP0003879_abnormal_hair_cell1.05219207
83MP0003755_abnormal_palate_morphology1.04506130
84MP0000372_irregular_coat_pigmentation1.04395080
85MP0004742_abnormal_vestibular_system1.03810827
86MP0003633_abnormal_nervous_system1.02218856
87MP0006036_abnormal_mitochondrial_physio1.00243684
88MP0008789_abnormal_olfactory_epithelium0.99759012
89MP0005171_absent_coat_pigmentation0.98776340
90MP0000049_abnormal_middle_ear0.98650828
91MP0001286_abnormal_eye_development0.97882165
92MP0002697_abnormal_eye_size0.96252681
93MP0001177_atelectasis0.95989289
94MP0003631_nervous_system_phenotype0.95729498
95MP0005645_abnormal_hypothalamus_physiol0.92548086
96MP0000631_abnormal_neuroendocrine_gland0.91670222
97MP0001299_abnormal_eye_distance/0.91583763
98MP0004085_abnormal_heartbeat0.90916977
99MP0002229_neurodegeneration0.87771126
100MP0005623_abnormal_meninges_morphology0.86071966
101MP0005391_vision/eye_phenotype0.85861531
102MP0003137_abnormal_impulse_conducting0.84940518
103MP0008877_abnormal_DNA_methylation0.84650478
104MP0004036_abnormal_muscle_relaxation0.84569031
105MP0010386_abnormal_urinary_bladder0.83484248
106MP0004147_increased_porphyrin_level0.82453560
107MP0002837_dystrophic_cardiac_calcinosis0.81764112
108MP0005195_abnormal_posterior_eye0.81548294
109MP0002752_abnormal_somatic_nervous0.81157629
110MP0005389_reproductive_system_phenotype0.80924749
111MP0002210_abnormal_sex_determination0.79895718
112MP0005551_abnormal_eye_electrophysiolog0.79701911
113MP0003861_abnormal_nervous_system0.78881817
114MP0003186_abnormal_redox_activity0.78751291
115MP0001485_abnormal_pinna_reflex0.78147515
116MP0005084_abnormal_gallbladder_morpholo0.78147079
117MP0003634_abnormal_glial_cell0.78084112
118MP0002160_abnormal_reproductive_system0.77581938
119MP0009250_abnormal_appendicular_skeleto0.77156801
120MP0004084_abnormal_cardiac_muscle0.76975882
121MP0002638_abnormal_pupillary_reflex0.76684239
122MP0003632_abnormal_nervous_system0.76669270
123MP0000747_muscle_weakness0.76428348
124MP0002069_abnormal_eating/drinking_beha0.74519520
125MP0001502_abnormal_circadian_rhythm0.74257312
126MP0005187_abnormal_penis_morphology0.73297989
127MP0001963_abnormal_hearing_physiology0.73239950
128MP0000534_abnormal_ureter_morphology0.71698387
129MP0005499_abnormal_olfactory_system0.70322065
130MP0005394_taste/olfaction_phenotype0.70322065
131MP0003385_abnormal_body_wall0.69757759
132MP0000749_muscle_degeneration0.67989297
133MP0002751_abnormal_autonomic_nervous0.67971265
134MP0004484_altered_response_of0.67161032
135MP0000569_abnormal_digit_pigmentation0.66123332
136MP0002653_abnormal_ependyma_morphology0.66112285
137MP0001943_abnormal_respiration0.65029436
138MP0003283_abnormal_digestive_organ0.61729880
139MP0002163_abnormal_gland_morphology0.59864594
140MP0010769_abnormal_survival0.59493162
141MP0010770_preweaning_lethality0.58410175
142MP0002082_postnatal_lethality0.58410175
143MP0002234_abnormal_pharynx_morphology0.56584080

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.51131842
2Myokymia (HP:0002411)5.19943258
3Atonic seizures (HP:0010819)4.86147862
4Focal seizures (HP:0007359)4.65320067
5Epileptic encephalopathy (HP:0200134)4.31675608
6Visual hallucinations (HP:0002367)4.26866399
7Febrile seizures (HP:0002373)3.72226340
8Absence seizures (HP:0002121)3.67578396
9Progressive cerebellar ataxia (HP:0002073)3.52860167
10Dialeptic seizures (HP:0011146)3.42300939
11Truncal ataxia (HP:0002078)3.26008786
12Ankle clonus (HP:0011448)3.08755927
13Action tremor (HP:0002345)3.01680820
14Abnormality of the labia minora (HP:0012880)2.93864942
15Generalized tonic-clonic seizures (HP:0002069)2.89606552
16Broad-based gait (HP:0002136)2.89134388
17Impaired vibration sensation in the lower limbs (HP:0002166)2.89133721
18Gaze-evoked nystagmus (HP:0000640)2.74706923
19Acute necrotizing encephalopathy (HP:0006965)2.73591864
20Hyperglycinemia (HP:0002154)2.69923358
21Pheochromocytoma (HP:0002666)2.69503961
22Volvulus (HP:0002580)2.69393573
23Limb dystonia (HP:0002451)2.62087779
24Scanning speech (HP:0002168)2.60462850
25Depression (HP:0000716)2.58604572
26Acute encephalopathy (HP:0006846)2.57070082
27Hyperventilation (HP:0002883)2.53454164
28Meckel diverticulum (HP:0002245)2.49274092
29Neuroendocrine neoplasm (HP:0100634)2.48535513
30Poor eye contact (HP:0000817)2.41707997
31Urinary bladder sphincter dysfunction (HP:0002839)2.40326658
32Impaired smooth pursuit (HP:0007772)2.39045422
33Abnormal mitochondria in muscle tissue (HP:0008316)2.37236503
34Abnormality of the ileum (HP:0001549)2.35151903
35Insidious onset (HP:0003587)2.34998944
36Termporal pattern (HP:0011008)2.34998944
37Abnormality of chromosome stability (HP:0003220)2.34667710
38Papilledema (HP:0001085)2.32512469
39Abnormal lung lobation (HP:0002101)2.32342207
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.32146190
41Dysdiadochokinesis (HP:0002075)2.32091229
42Anxiety (HP:0000739)2.31527681
43Pancreatic fibrosis (HP:0100732)2.30721642
44Progressive macrocephaly (HP:0004481)2.29917667
45Gait imbalance (HP:0002141)2.25999654
46Excessive salivation (HP:0003781)2.23723043
47Drooling (HP:0002307)2.23723043
48Abnormal eating behavior (HP:0100738)2.23219903
49Increased serum pyruvate (HP:0003542)2.23154638
50Supranuclear gaze palsy (HP:0000605)2.23070724
51Dysmetria (HP:0001310)2.21988306
52Colon cancer (HP:0003003)2.20888426
53Abnormal social behavior (HP:0012433)2.13083799
54Impaired social interactions (HP:0000735)2.13083799
55Genetic anticipation (HP:0003743)2.13079466
56Megalencephaly (HP:0001355)2.12887976
57Abnormality of midbrain morphology (HP:0002418)2.12521241
58Molar tooth sign on MRI (HP:0002419)2.12521241
59Urinary urgency (HP:0000012)2.10916931
60Abnormality of ocular smooth pursuit (HP:0000617)2.05611348
61Neoplasm of the peripheral nervous system (HP:0100007)2.05131092
62Amblyopia (HP:0000646)2.05069779
63Abnormality of glycolysis (HP:0004366)2.04221486
64Dysmetric saccades (HP:0000641)2.03818061
65Poor suck (HP:0002033)2.03684539
66Abnormality of the preputium (HP:0100587)2.01839782
67Aplasia/Hypoplasia of the tibia (HP:0005772)2.01755702
68Congenital primary aphakia (HP:0007707)2.01545230
69Increased CSF lactate (HP:0002490)2.00782930
70Bradykinesia (HP:0002067)2.00067214
71Abnormal hair whorl (HP:0010721)1.99397205
72Short tibia (HP:0005736)1.99201314
73Abnormality of the lower motor neuron (HP:0002366)1.98719215
74Methylmalonic acidemia (HP:0002912)1.97846896
75Delusions (HP:0000746)1.97428406
76Unsteady gait (HP:0002317)1.96062064
77Mitochondrial inheritance (HP:0001427)1.95686018
78Epileptiform EEG discharges (HP:0011182)1.95682893
79Ependymoma (HP:0002888)1.95446270
80Cortical dysplasia (HP:0002539)1.94438707
81True hermaphroditism (HP:0010459)1.93993885
82Nephronophthisis (HP:0000090)1.93478416
83Abnormality of pain sensation (HP:0010832)1.90505553
84Impaired pain sensation (HP:0007328)1.90505553
85Astrocytoma (HP:0009592)1.90137745
86Abnormality of the astrocytes (HP:0100707)1.90137745
87Spastic gait (HP:0002064)1.90088416
88Chromsome breakage (HP:0040012)1.89716916
893-Methylglutaconic aciduria (HP:0003535)1.89607573
90Chromosomal breakage induced by crosslinking agents (HP:0003221)1.87199829
91Intestinal atresia (HP:0011100)1.87178977
92Hemiparesis (HP:0001269)1.87110267
93Impaired vibratory sensation (HP:0002495)1.87077821
94Resting tremor (HP:0002322)1.86455986
95Specific learning disability (HP:0001328)1.85622173
96Progressive inability to walk (HP:0002505)1.85353338
97Retinal dysplasia (HP:0007973)1.84184825
98Supernumerary spleens (HP:0009799)1.84007253
99Pendular nystagmus (HP:0012043)1.83857518
100Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.83645467
101Scrotal hypoplasia (HP:0000046)1.83401012
102Abnormality of serine family amino acid metabolism (HP:0010894)1.83074880
103Abnormality of glycine metabolism (HP:0010895)1.83074880
104Pancreatic cysts (HP:0001737)1.82771414
105Postaxial hand polydactyly (HP:0001162)1.82351871
106Median cleft lip (HP:0000161)1.81906208
107Dandy-Walker malformation (HP:0001305)1.81769777
108Stereotypic behavior (HP:0000733)1.81550244
109Abnormality of the corticospinal tract (HP:0002492)1.81345807
110Nephrogenic diabetes insipidus (HP:0009806)1.81277450
111Cerebral edema (HP:0002181)1.81244470
112Medial flaring of the eyebrow (HP:0010747)1.80730649
113Facial cleft (HP:0002006)1.80622092
114Mutism (HP:0002300)1.80554696
115Shoulder girdle muscle weakness (HP:0003547)1.79314806
116EEG with generalized epileptiform discharges (HP:0011198)1.78600743
117Vaginal atresia (HP:0000148)1.78495300
118Annular pancreas (HP:0001734)1.78435554
119Genital tract atresia (HP:0001827)1.78044860
120Hypoventilation (HP:0002791)1.77611025
121Preaxial hand polydactyly (HP:0001177)1.77573910
122Generalized hypotonia (HP:0001290)1.77280938
123Glioma (HP:0009733)1.77248473
124Spinal canal stenosis (HP:0003416)1.76761456
125Pointed chin (HP:0000307)1.75522595
126Aqueductal stenosis (HP:0002410)1.75370489
127Type II lissencephaly (HP:0007260)1.75303761
128Delayed gross motor development (HP:0002194)1.75105105
129Postural instability (HP:0002172)1.74420799
130Amyotrophic lateral sclerosis (HP:0007354)1.71418853
131Patellar aplasia (HP:0006443)1.71158774
132Hypsarrhythmia (HP:0002521)1.70322293
133Absent speech (HP:0001344)1.70313155
134Sloping forehead (HP:0000340)1.70195594
135Protruding tongue (HP:0010808)1.69451632
136Polyphagia (HP:0002591)1.69260606
137Cerebral hypomyelination (HP:0006808)1.69022525
138Hyperglycinuria (HP:0003108)1.68947404
139Abnormality of binocular vision (HP:0011514)1.68679633
140Diplopia (HP:0000651)1.68679633
141Triphalangeal thumb (HP:0001199)1.68559302
142Hepatocellular necrosis (HP:0001404)1.68085379
143Lissencephaly (HP:0001339)1.67701395
144Birth length less than 3rd percentile (HP:0003561)1.67660769
145Hepatoblastoma (HP:0002884)1.66864125
146Bifid tongue (HP:0010297)1.66716341
147Failure to thrive in infancy (HP:0001531)1.64973864
148Incomplete penetrance (HP:0003829)1.64830463
149Aplasia/Hypoplasia of the brainstem (HP:0007362)1.64650641
150Hypoplasia of the brainstem (HP:0002365)1.64650641
151Fetal akinesia sequence (HP:0001989)1.64213966
152Renal hypoplasia (HP:0000089)1.63972535
153Sclerocornea (HP:0000647)1.63611892
154Aplasia/Hypoplasia of the tongue (HP:0010295)1.62793102
155Postaxial foot polydactyly (HP:0001830)1.61994915
156Decreased testicular size (HP:0008734)1.60703723
157Hemiplegia (HP:0002301)1.60698398
158Abnormality of the duodenum (HP:0002246)1.60375304
159Menstrual irregularities (HP:0000858)1.59969647
160Poor coordination (HP:0002370)1.59916592
161Medulloblastoma (HP:0002885)1.59311989
162Hepatic necrosis (HP:0002605)1.59099837
163Generalized myoclonic seizures (HP:0002123)1.58919560
164Small intestinal stenosis (HP:0012848)1.57813027
165Duodenal stenosis (HP:0100867)1.57813027
166Anophthalmia (HP:0000528)1.57414064
167Aplasia/Hypoplasia of the patella (HP:0006498)1.57151898
168Aplasia/Hypoplasia of the sternum (HP:0006714)1.57110574
169Rimmed vacuoles (HP:0003805)1.57046107
170Abnormality of serum amino acid levels (HP:0003112)1.56504953
171Optic nerve hypoplasia (HP:0000609)1.56404412
172Pachygyria (HP:0001302)1.56387360
173Increased hepatocellular lipid droplets (HP:0006565)1.56244921
174Increased serum lactate (HP:0002151)1.55527337
175Deep palmar crease (HP:0006191)1.55477425

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.74488175
2EPHA43.41130237
3CASK3.30105356
4MAP3K43.11074805
5MAP3K93.06570906
6TRIM282.96203113
7MAP2K72.70649648
8MKNK22.65439383
9MINK12.61703122
10MAP3K122.51026737
11SRPK12.49069576
12MARK12.35154632
13EIF2AK12.25692696
14PLK22.21885860
15WEE12.12586658
16NTRK12.06093462
17CDK192.03041611
18AKT32.03007351
19KSR11.94605485
20KSR21.93331995
21PRKD31.86656348
22MAPK131.83498611
23PAK61.83333284
24TAF11.83118725
25MKNK11.80540355
26TTK1.67496131
27DAPK21.66125123
28VRK21.66017740
29DAPK11.64596975
30MAP2K41.61685421
31ERBB31.58021564
32MAP4K21.57635366
33NUAK11.56771166
34EIF2AK31.53516321
35BRSK21.50646051
36PNCK1.50399446
37DYRK21.42290901
38PBK1.41983169
39STK161.41954628
40CAMKK21.38542303
41CSNK1G11.38405660
42NTRK21.37909243
43DYRK31.35006870
44LATS21.32805302
45FRK1.32484830
46ARAF1.31084022
47CDK51.29631541
48CAMKK11.28357872
49PLK11.27841943
50NEK11.26229775
51TSSK61.24826560
52TNIK1.21662657
53GRK51.19649313
54UHMK11.17536631
55PRKCG1.17164511
56PLK41.13919985
57SGK4941.12416425
58SGK2231.12416425
59VRK11.12180047
60BMPR1B1.12129151
61CDK181.11783890
62CDK141.11531940
63PRPF4B1.08920948
64OXSR11.07321917
65CDK151.05799567
66INSRR1.02466132
67SGK21.02301119
68BRAF1.02016587
69ZAK1.01662045
70BRSK11.01396800
71PTK2B1.01186166
72MUSK1.00119317
73CCNB11.00105150
74PHKG10.96434811
75PHKG20.96434811
76CDK11A0.93065714
77BCR0.92172048
78CAMK2A0.90310288
79SCYL20.89262565
80RIPK40.89262437
81STK38L0.87746407
82CSNK1G20.87701572
83CAMK2B0.86145021
84CDC70.82979192
85STK380.80187597
86PLK30.78955582
87RAF10.75848298
88STK390.74963837
89WNK30.69869320
90CAMK10.69407416
91PAK30.67795573
92SGK30.67585201
93SIK30.67402873
94CHEK20.66373105
95LIMK10.66181195
96PRKCH0.64999357
97RET0.64509320
98OBSCN0.64438352
99ACVR1B0.64092620
100CDK30.63117780
101ERBB40.63051410
102ATM0.62337507
103WNK40.61573901
104MST40.59163642
105ATR0.58893664
106DYRK1A0.58718454
107PDK30.58467251
108PDK40.58467251
109EIF2AK20.57715656
110RPS6KA40.57115157
111WNK10.56357376
112PIK3CA0.56190166
113AURKB0.54617318
114CSNK1G30.54192948
115PRKCE0.53905211
116BUB10.53406225
117CSNK1E0.53190498
118CSNK1A1L0.52321355
119FER0.49935313
120ROCK20.48829551
121TYRO30.48063573
122NEK20.47852396
123MAP3K20.47632150
124PKN10.47210113
125GRK10.46523538
126SGK10.46246818
127MAPK100.45561272
128MAP2K10.44389410
129BCKDK0.44049830
130DDR20.43500371
131CAMK2D0.43440711
132AURKA0.43017180
133CHEK10.42270395
134SIK20.42210831
135STK110.41941174
136CDK80.41846029
137ADRBK10.41763894
138CSNK1D0.41756997
139PRKDC0.41240980
140BMPR20.41060102
141RPS6KA30.40100890
142NME10.39597292
143CAMK2G0.39459355
144CDK10.38680707
145CDC42BPA0.38238264
146ALK0.35547352
147CAMK40.35231956
148PDGFRA0.30278858
149PINK10.30266118
150LMTK20.29590351
151FGFR20.29423121

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.47873449
2Synaptic vesicle cycle_Homo sapiens_hsa047213.43086611
3Long-term potentiation_Homo sapiens_hsa047202.62243468
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.59396780
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.54109846
6GABAergic synapse_Homo sapiens_hsa047272.50790865
7Circadian entrainment_Homo sapiens_hsa047132.49593594
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.48534367
9Protein export_Homo sapiens_hsa030602.47159440
10Olfactory transduction_Homo sapiens_hsa047402.41678782
11Proteasome_Homo sapiens_hsa030502.35999801
12Morphine addiction_Homo sapiens_hsa050322.31592127
13Non-homologous end-joining_Homo sapiens_hsa034502.30936797
14Glutamatergic synapse_Homo sapiens_hsa047242.25150386
15Steroid biosynthesis_Homo sapiens_hsa001002.18824494
16Mismatch repair_Homo sapiens_hsa034302.17067551
17Amphetamine addiction_Homo sapiens_hsa050312.14945991
18Dopaminergic synapse_Homo sapiens_hsa047282.14328413
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.99128300
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.97743020
21Fanconi anemia pathway_Homo sapiens_hsa034601.89046522
22Propanoate metabolism_Homo sapiens_hsa006401.87779031
23Collecting duct acid secretion_Homo sapiens_hsa049661.83740882
24RNA polymerase_Homo sapiens_hsa030201.80755761
25Long-term depression_Homo sapiens_hsa047301.79961154
26DNA replication_Homo sapiens_hsa030301.79734333
27Basal transcription factors_Homo sapiens_hsa030221.76790249
28Insulin secretion_Homo sapiens_hsa049111.76714863
29Salivary secretion_Homo sapiens_hsa049701.76360133
30Cholinergic synapse_Homo sapiens_hsa047251.75365002
31Homologous recombination_Homo sapiens_hsa034401.74305633
32Taste transduction_Homo sapiens_hsa047421.70734580
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.68058753
34Butanoate metabolism_Homo sapiens_hsa006501.67609177
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67233290
36Serotonergic synapse_Homo sapiens_hsa047261.62406402
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60919481
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.58420526
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57167708
40Gastric acid secretion_Homo sapiens_hsa049711.56869325
41Oxytocin signaling pathway_Homo sapiens_hsa049211.56102027
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54755894
43Oocyte meiosis_Homo sapiens_hsa041141.53354732
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.50951523
45Renin secretion_Homo sapiens_hsa049241.49474698
46Folate biosynthesis_Homo sapiens_hsa007901.48893615
47Spliceosome_Homo sapiens_hsa030401.47576409
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.45189129
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43514552
50RNA degradation_Homo sapiens_hsa030181.43056779
51Calcium signaling pathway_Homo sapiens_hsa040201.42869835
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42756800
53Base excision repair_Homo sapiens_hsa034101.42751728
54Nucleotide excision repair_Homo sapiens_hsa034201.41498114
55Gap junction_Homo sapiens_hsa045401.36926661
56RNA transport_Homo sapiens_hsa030131.36861576
57Pyruvate metabolism_Homo sapiens_hsa006201.33755683
58Vitamin B6 metabolism_Homo sapiens_hsa007501.29325997
59GnRH signaling pathway_Homo sapiens_hsa049121.28292203
60Cocaine addiction_Homo sapiens_hsa050301.27382013
61Cysteine and methionine metabolism_Homo sapiens_hsa002701.21952258
62Fatty acid elongation_Homo sapiens_hsa000621.21489730
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20990894
64Glioma_Homo sapiens_hsa052141.20965454
65Vibrio cholerae infection_Homo sapiens_hsa051101.19465577
66Cardiac muscle contraction_Homo sapiens_hsa042601.13106228
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10982685
68One carbon pool by folate_Homo sapiens_hsa006701.09066282
69Axon guidance_Homo sapiens_hsa043601.08379690
70cAMP signaling pathway_Homo sapiens_hsa040241.08102365
71Melanogenesis_Homo sapiens_hsa049161.06867623
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06670627
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03561947
74Estrogen signaling pathway_Homo sapiens_hsa049151.01897010
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01792870
76Pyrimidine metabolism_Homo sapiens_hsa002401.00340969
77Fatty acid metabolism_Homo sapiens_hsa012120.99857252
78ErbB signaling pathway_Homo sapiens_hsa040120.99062562
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99001302
80Selenocompound metabolism_Homo sapiens_hsa004500.98425263
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97074663
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95999230
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95373677
84Phototransduction_Homo sapiens_hsa047440.94282069
85mRNA surveillance pathway_Homo sapiens_hsa030150.91766318
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91580027
87Dilated cardiomyopathy_Homo sapiens_hsa054140.91536413
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.88127835
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87904089
90Alcoholism_Homo sapiens_hsa050340.87175602
91Purine metabolism_Homo sapiens_hsa002300.85160303
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82913560
93Peroxisome_Homo sapiens_hsa041460.82412520
94Type II diabetes mellitus_Homo sapiens_hsa049300.79705190
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79021455
96Renal cell carcinoma_Homo sapiens_hsa052110.74622180
97Fatty acid degradation_Homo sapiens_hsa000710.73699329
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.71619996
99MAPK signaling pathway_Homo sapiens_hsa040100.71288560
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70559976
101Carbon metabolism_Homo sapiens_hsa012000.69951548
102Rap1 signaling pathway_Homo sapiens_hsa040150.69336887
103Oxidative phosphorylation_Homo sapiens_hsa001900.69237221
104Wnt signaling pathway_Homo sapiens_hsa043100.68363726
105Metabolic pathways_Homo sapiens_hsa011000.67520836
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67198447
107Arginine and proline metabolism_Homo sapiens_hsa003300.67017408
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.66926288
109Alzheimers disease_Homo sapiens_hsa050100.65931637
110beta-Alanine metabolism_Homo sapiens_hsa004100.64841346
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.64585333
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64506153
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.64492511
114Ras signaling pathway_Homo sapiens_hsa040140.64486439
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63031187
116Circadian rhythm_Homo sapiens_hsa047100.62919431
117Dorso-ventral axis formation_Homo sapiens_hsa043200.61708517
118Biosynthesis of amino acids_Homo sapiens_hsa012300.61649187
119Parkinsons disease_Homo sapiens_hsa050120.61099559
120Colorectal cancer_Homo sapiens_hsa052100.60179411
121Thyroid hormone synthesis_Homo sapiens_hsa049180.59682787
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59573531
123Choline metabolism in cancer_Homo sapiens_hsa052310.58815788
124Glutathione metabolism_Homo sapiens_hsa004800.58477074
125Endocytosis_Homo sapiens_hsa041440.57946598
126Endometrial cancer_Homo sapiens_hsa052130.57795695
127Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57146175
128mTOR signaling pathway_Homo sapiens_hsa041500.56149958
129Sulfur relay system_Homo sapiens_hsa041220.54735052
130Caffeine metabolism_Homo sapiens_hsa002320.54445780
131Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54171061
132Glucagon signaling pathway_Homo sapiens_hsa049220.53728096
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53706625
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53586096
135Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53268539
136Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53080222
137Tryptophan metabolism_Homo sapiens_hsa003800.52499216
138Non-small cell lung cancer_Homo sapiens_hsa052230.51887282
139Huntingtons disease_Homo sapiens_hsa050160.49561383
140Hippo signaling pathway_Homo sapiens_hsa043900.49442332
141VEGF signaling pathway_Homo sapiens_hsa043700.49081791
142N-Glycan biosynthesis_Homo sapiens_hsa005100.48980469
143Melanoma_Homo sapiens_hsa052180.48950592
144Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48359982
145Pancreatic secretion_Homo sapiens_hsa049720.46983160
146p53 signaling pathway_Homo sapiens_hsa041150.46681042
147Basal cell carcinoma_Homo sapiens_hsa052170.46201543
148Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45776487
149Hedgehog signaling pathway_Homo sapiens_hsa043400.44887473
150Sphingolipid signaling pathway_Homo sapiens_hsa040710.44309470
151Tight junction_Homo sapiens_hsa045300.43640567
152Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43133699
153Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43092503
154Cell cycle_Homo sapiens_hsa041100.41982191
155Nitrogen metabolism_Homo sapiens_hsa009100.41510293
156Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41435344
157TGF-beta signaling pathway_Homo sapiens_hsa043500.41369722
158Inositol phosphate metabolism_Homo sapiens_hsa005620.40737367
159Insulin signaling pathway_Homo sapiens_hsa049100.40495497
160Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40303283
161Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39065599
162Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37742334
163Ovarian steroidogenesis_Homo sapiens_hsa049130.37302609
164Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37147759

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