BROX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of DNA endoreduplication (GO:0032875)5.53305030
2regulation of interleukin-12 biosynthetic process (GO:0045075)5.50820082
3pyrimidine nucleoside salvage (GO:0043097)4.91527873
4pyrimidine-containing compound salvage (GO:0008655)4.91527873
5positive regulation of protein autophosphorylation (GO:0031954)4.80335707
6mitochondrial DNA replication (GO:0006264)4.59354816
7water-soluble vitamin biosynthetic process (GO:0042364)4.54379295
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.42481650
9response to pheromone (GO:0019236)4.37356342
10macroautophagy (GO:0016236)4.34649402
11nerve growth factor signaling pathway (GO:0038180)4.27864975
12negative regulation of protein oligomerization (GO:0032460)4.20894512
13DNA double-strand break processing (GO:0000729)4.16118780
14negative regulation of interleukin-17 production (GO:0032700)4.15885407
15DNA deamination (GO:0045006)4.11093269
16regulation of interferon-beta biosynthetic process (GO:0045357)3.95595820
17respiratory chain complex IV assembly (GO:0008535)3.90697353
18I-kappaB phosphorylation (GO:0007252)3.89969161
19neuron remodeling (GO:0016322)3.88365285
20negative regulation of DNA-dependent DNA replication (GO:2000104)3.84438734
21regulation of type B pancreatic cell apoptotic process (GO:2000674)3.82559762
22sulfation (GO:0051923)3.78329811
23positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.77120182
24deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.76912685
25positive regulation of protein sumoylation (GO:0033235)3.73284304
26mitochondrial DNA metabolic process (GO:0032042)3.70844601
27positive regulation of T cell chemotaxis (GO:0010820)3.70478130
28regulation of T cell chemotaxis (GO:0010819)3.70478130
29cellular response to nerve growth factor stimulus (GO:1990090)3.65492502
30response to nerve growth factor (GO:1990089)3.65492502
31lactate metabolic process (GO:0006089)3.62936865
32magnesium ion transport (GO:0015693)3.56984600
33protein prenylation (GO:0018342)3.54464827
34prenylation (GO:0097354)3.54464827
35positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.52581722
36proteasome assembly (GO:0043248)3.49664710
37prostate gland growth (GO:0060736)3.47335162
38regulation of glucokinase activity (GO:0033131)3.45010238
39regulation of hexokinase activity (GO:1903299)3.45010238
40keratinocyte development (GO:0003334)3.44988029
41positive regulation of macrophage cytokine production (GO:0060907)3.41724390
42protein complex biogenesis (GO:0070271)3.40590902
43cytochrome complex assembly (GO:0017004)3.38286204
44signal peptide processing (GO:0006465)3.37645624
45phosphatidylinositol dephosphorylation (GO:0046856)3.37560241
46regulation of protein autophosphorylation (GO:0031952)3.33609221
47negative regulation of dendrite development (GO:2000171)3.33238594
48replication fork processing (GO:0031297)3.31303479
49cullin deneddylation (GO:0010388)3.30212425
50nucleoside salvage (GO:0043174)3.29190372
51inositol phosphate catabolic process (GO:0071545)3.24300216
52synapsis (GO:0007129)3.21545474
53mitochondrial respiratory chain complex assembly (GO:0033108)3.19354863
54mitochondrial respiratory chain complex I assembly (GO:0032981)3.19333457
55NADH dehydrogenase complex assembly (GO:0010257)3.19333457
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.19333457
57negative regulation of membrane potential (GO:0045837)3.17221225
58phospholipid dephosphorylation (GO:0046839)3.14920177
59platelet dense granule organization (GO:0060155)3.13830184
60dorsal/ventral axis specification (GO:0009950)3.08395975
61striatum development (GO:0021756)3.07548908
62modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.05277434
63positive regulation by organism of defense response of other organism involved in symbiotic interact3.05277434
64modulation by symbiont of host immune response (GO:0052553)3.05277434
65positive regulation by symbiont of host defense response (GO:0052509)3.05277434
66modulation by symbiont of host defense response (GO:0052031)3.05277434
67modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.05277434
68protein K11-linked deubiquitination (GO:0035871)3.03179352
69protein K6-linked ubiquitination (GO:0085020)3.02922144
70somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.02663265
71isotype switching (GO:0045190)3.02663265
72somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.02663265
73positive regulation of interferon-alpha production (GO:0032727)3.02520004
74regulation of protein homooligomerization (GO:0032462)3.00813152
75protein deneddylation (GO:0000338)3.00547090
76phosphorylated carbohydrate dephosphorylation (GO:0046838)2.97346528
77inositol phosphate dephosphorylation (GO:0046855)2.97346528
78positive regulation of glycolytic process (GO:0045821)2.97166881
79dentate gyrus development (GO:0021542)2.92066962
80RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.91661085
81positive regulation of glycoprotein biosynthetic process (GO:0010560)2.88766716
82purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.86776725
833-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.86776725
84regulation of axon regeneration (GO:0048679)2.86505542
85regulation of neuron projection regeneration (GO:0070570)2.86505542
86regulation of meiosis I (GO:0060631)2.85238771
87ketone body metabolic process (GO:1902224)2.83998068
88regulation of interferon-alpha production (GO:0032647)2.82362973
89preassembly of GPI anchor in ER membrane (GO:0016254)2.81528951
90production of molecular mediator involved in inflammatory response (GO:0002532)2.81469079
91protein localization to endosome (GO:0036010)2.78463106
92regulation of lymphocyte chemotaxis (GO:1901623)2.78073031
93parental behavior (GO:0060746)2.74428020
94regulation of protein glycosylation (GO:0060049)2.74256160
95regulation of collateral sprouting (GO:0048670)2.74240443
96positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.72935004
97regulation of interleukin-8 biosynthetic process (GO:0045414)2.72879707
98polyol catabolic process (GO:0046174)2.72694915
99maturation of 5.8S rRNA (GO:0000460)2.71951865
100negative regulation of neurological system process (GO:0031645)2.68759608
101zinc ion transport (GO:0006829)2.65609687
102cellular response to fluid shear stress (GO:0071498)2.64174180
103glandular epithelial cell development (GO:0002068)2.63529765
104double-strand break repair via homologous recombination (GO:0000724)2.62846682
105positive regulation of chemokine biosynthetic process (GO:0045080)2.62420505
106COPI coating of Golgi vesicle (GO:0048205)2.62317523
107Golgi transport vesicle coating (GO:0048200)2.62317523
108recombinational repair (GO:0000725)2.61911265
109synaptic vesicle maturation (GO:0016188)2.61348722
110response to nitrosative stress (GO:0051409)2.59016332
111righting reflex (GO:0060013)2.58076699
112positive regulation of vesicle fusion (GO:0031340)2.57243282
113establishment of endothelial barrier (GO:0061028)2.55670966
114reflex (GO:0060004)2.54777764
115exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.54716019
116clathrin coat assembly (GO:0048268)2.53978881
117nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.51624230
118regulation of mesoderm development (GO:2000380)2.50306702
119histone H3-K4 trimethylation (GO:0080182)2.50030208
120macrophage activation involved in immune response (GO:0002281)2.49749768
121tryptophan catabolic process (GO:0006569)2.48603315
122indole-containing compound catabolic process (GO:0042436)2.48603315
123indolalkylamine catabolic process (GO:0046218)2.48603315
124dendrite morphogenesis (GO:0048813)2.48367497
125regulation of macrophage cytokine production (GO:0010935)2.47860617
126regulation of glomerulus development (GO:0090192)2.47550047
127mannosylation (GO:0097502)2.47243889
128positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.46887020
129exploration behavior (GO:0035640)2.46306285
130detection of molecule of bacterial origin (GO:0032490)2.46243037
131fucose catabolic process (GO:0019317)2.45920445
132L-fucose metabolic process (GO:0042354)2.45920445
133L-fucose catabolic process (GO:0042355)2.45920445
134rRNA methylation (GO:0031167)2.45630350
135signal transduction involved in regulation of gene expression (GO:0023019)2.45594467
136regulation of protein sumoylation (GO:0033233)2.45191998
137positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.45128281
138positive regulation of protein deacetylation (GO:0090312)2.44749834
139detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.44470861
140regulation of vitamin D biosynthetic process (GO:0060556)2.43966809
141piRNA metabolic process (GO:0034587)2.42654838
142negative regulation of JUN kinase activity (GO:0043508)2.41734147
143positive regulation of mitotic sister chromatid separation (GO:1901970)2.40918596
144positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.40918596
145positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.40918596
146heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.40703890
147histone H2A ubiquitination (GO:0033522)2.39870692
148nitric oxide mediated signal transduction (GO:0007263)2.39776720
149DNA catabolic process, exonucleolytic (GO:0000738)2.39724922
150negative regulation of acute inflammatory response (GO:0002674)2.39137325
151detection of light stimulus involved in sensory perception (GO:0050962)2.38365087
152detection of light stimulus involved in visual perception (GO:0050908)2.38365087
153protein neddylation (GO:0045116)2.37883500
154indolalkylamine metabolic process (GO:0006586)2.37323505
155regulation of B cell apoptotic process (GO:0002902)2.36528972
156dopamine transport (GO:0015872)2.36415459
157cytoplasmic mRNA processing body assembly (GO:0033962)2.35668320
158regulation of synaptic vesicle exocytosis (GO:2000300)2.34970736
159N-acetylglucosamine metabolic process (GO:0006044)2.34659497
160negative regulation of protein autophosphorylation (GO:0031953)2.34510439
161regulation of MHC class II biosynthetic process (GO:0045346)2.33269558
162embryonic viscerocranium morphogenesis (GO:0048703)2.32966810
163immunoglobulin mediated immune response (GO:0016064)2.32710686
164behavioral response to nicotine (GO:0035095)2.32032783
165positive regulation of NF-kappaB import into nucleus (GO:0042346)2.31493235
166regulation of neurotransmitter uptake (GO:0051580)2.31237772
167xenobiotic catabolic process (GO:0042178)2.30844560
168growth hormone receptor signaling pathway (GO:0060396)2.30564472
169neutrophil activation involved in immune response (GO:0002283)2.30251788
170insulin secretion (GO:0030073)2.30245406
171regulation of gamma-delta T cell differentiation (GO:0045586)2.30188359
172regulation of germinal center formation (GO:0002634)2.30160022
173negative regulation of axon extension involved in axon guidance (GO:0048843)2.29719771
174C-terminal protein lipidation (GO:0006501)2.28918798
175regulation of protein oligomerization (GO:0032459)2.26461805
176regulation of interleukin-17 production (GO:0032660)2.24858215
177regulation of heat generation (GO:0031650)2.24691561
178regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.24659507
179pyrimidine nucleobase metabolic process (GO:0006206)2.23148533
180cell adhesion mediated by integrin (GO:0033627)2.21691224
181striated muscle atrophy (GO:0014891)2.19572843
182proline transport (GO:0015824)2.16833568
183positive regulation of interferon-beta production (GO:0032728)2.16704432
184negative regulation of axon extension (GO:0030517)2.16347392
185response to host immune response (GO:0052572)2.13030944
186response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.13030944
187positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.10937812
188response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.10808533
189response to host (GO:0075136)2.10808533
190response to host defenses (GO:0052200)2.10808533
191negative regulation of chondrocyte differentiation (GO:0032331)2.10801081
192phagocytosis, engulfment (GO:0006911)2.09228304
193snRNA processing (GO:0016180)2.08876664
194regulation of gamma-delta T cell activation (GO:0046643)2.08690871
195cellular response to ethanol (GO:0071361)2.07851791
196cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.07299274
197regulation of sarcomere organization (GO:0060297)2.06855020
198barbed-end actin filament capping (GO:0051016)2.06685294

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.78306547
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.57641459
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.45821874
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.91811142
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.73527048
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.68407126
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.61891587
8VDR_22108803_ChIP-Seq_LS180_Human2.48267852
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.47703184
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.43491088
11ZNF274_21170338_ChIP-Seq_K562_Hela2.42495082
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.42160158
13EWS_26573619_Chip-Seq_HEK293_Human2.40229627
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.37814937
15ELK1_19687146_ChIP-ChIP_HELA_Human2.23837124
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.23519396
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.23332504
18FUS_26573619_Chip-Seq_HEK293_Human2.22800712
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.20095703
20P300_19829295_ChIP-Seq_ESCs_Human2.17773195
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.08922770
22IGF1R_20145208_ChIP-Seq_DFB_Human2.07720329
23SMAD_19615063_ChIP-ChIP_OVARY_Human2.07677360
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.02866752
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.98323888
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.95306429
27TAF15_26573619_Chip-Seq_HEK293_Human1.94174663
28RUNX_20019798_ChIP-Seq_JUKART_Human1.91142775
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88233949
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86091969
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.85167527
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84884891
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.80858585
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.73161055
35EZH2_27294783_Chip-Seq_NPCs_Mouse1.71485221
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68531477
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.68443806
38SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67676397
39ER_23166858_ChIP-Seq_MCF-7_Human1.67403722
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66184958
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.66163784
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.65659080
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.60748775
44SPI1_23127762_ChIP-Seq_K562_Human1.59302724
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57422963
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.57373897
47CJUN_26792858_Chip-Seq_BT549_Human1.57090077
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55679405
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54679513
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53207583
51NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.51664469
52BCAT_22108803_ChIP-Seq_LS180_Human1.51479073
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48386881
54MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47829732
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47332792
56CBP_20019798_ChIP-Seq_JUKART_Human1.47332792
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47140274
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.46422479
59RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.45707942
60NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45694779
61CLOCK_20551151_ChIP-Seq_293T_Human1.45294819
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.44285090
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.43714081
64GBX2_23144817_ChIP-Seq_PC3_Human1.42588379
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41662588
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39521035
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38618813
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38289469
69VDR_24787735_ChIP-Seq_THP-1_Human1.38088558
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.38064883
71P53_22387025_ChIP-Seq_ESCs_Mouse1.38048824
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.37843034
73PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36564888
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36134575
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.36121433
76CDX2_22108803_ChIP-Seq_LS180_Human1.35552867
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.34769082
78KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34563601
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31802277
80SOX2_19829295_ChIP-Seq_ESCs_Human1.31759372
81NANOG_19829295_ChIP-Seq_ESCs_Human1.31759372
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30952594
83VDR_23849224_ChIP-Seq_CD4+_Human1.30950592
84BP1_19119308_ChIP-ChIP_Hs578T_Human1.30867080
85STAT3_23295773_ChIP-Seq_U87_Human1.30674652
86NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30571708
87ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28836240
88FOXO3_23340844_ChIP-Seq_DLD1_Human1.28640888
89VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26376636
90KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26342067
91PU_27001747_Chip-Seq_BMDM_Mouse1.25982235
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25581732
93RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24934086
94TRIM28_21343339_ChIP-Seq_HEK293_Human1.23970769
95CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23841375
96TP53_16413492_ChIP-PET_HCT116_Human1.23529901
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22620779
98* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.22418075
99PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22245180
100NOTCH1_21737748_ChIP-Seq_TLL_Human1.22193133
101E2F1_18555785_Chip-Seq_ESCs_Mouse1.22183784
102TCF4_22108803_ChIP-Seq_LS180_Human1.22176164
103SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22071999
104TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22016618
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21814898
106KDM2B_26808549_Chip-Seq_DND41_Human1.21572870
107MYC_18940864_ChIP-ChIP_HL60_Human1.21417848
108CMYC_18555785_Chip-Seq_ESCs_Mouse1.21233054
109EGR1_23403033_ChIP-Seq_LIVER_Mouse1.21218283
110FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20955197
111GATA1_22025678_ChIP-Seq_K562_Human1.20318141
112TCF4_23295773_ChIP-Seq_U87_Human1.19833178
113P300_18555785_Chip-Seq_ESCs_Mouse1.19233273
114SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.18229009
115NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18200559
116ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17536891
117STAT3_18555785_Chip-Seq_ESCs_Mouse1.17305589
118GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17089502
119POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16192925
120TCF4_18268006_ChIP-ChIP_LS174T_Human1.15837076
121ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13835194
122EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13746766
123OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13668126
124SOX2_18555785_Chip-Seq_ESCs_Mouse1.13417263
125WT1_19549856_ChIP-ChIP_CCG9911_Human1.12221423
126E2F4_17652178_ChIP-ChIP_JURKAT_Human1.12059098
127PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11254161
128SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10915203
129AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10901497
130FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10004183
131SMAD4_21741376_ChIP-Seq_EPCs_Human1.09985661
132CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09876272
133ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09528946
134TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09154431
135KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08860662
136P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08073775
137ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07548628
138DROSHA_22980978_ChIP-Seq_HELA_Human1.07420406
139EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07351750
140E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06687880
141SRF_21415370_ChIP-Seq_HL-1_Mouse1.06550095
142OCT4_18555785_Chip-Seq_ESCs_Mouse1.05974476
143FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04468799
144FLI1_21867929_ChIP-Seq_TH2_Mouse1.04463594
145KDM2B_26808549_Chip-Seq_K562_Human1.04402189
146POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04315103
147FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04282385
148FOXA1_25329375_ChIP-Seq_VCAP_Human1.04282385
149MYC_22102868_ChIP-Seq_BL_Human1.03905940
150BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02620470
151EP300_21415370_ChIP-Seq_HL-1_Mouse1.01937593
152PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01757043
153WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00681233
154AR_25329375_ChIP-Seq_VCAP_Human0.98868231
155BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98421282
156AHR_22903824_ChIP-Seq_MCF-7_Human0.98247345
157NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96992901
158NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96992901
159EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96542312
160ARNT_22903824_ChIP-Seq_MCF-7_Human0.96327390
161FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95720521
162EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95132044
163RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.94891456
164TP53_18474530_ChIP-ChIP_U2OS_Human0.94588368
165SCL_19346495_ChIP-Seq_HPC-7_Human0.94309479
166SMAD4_21799915_ChIP-Seq_A2780_Human0.93512952
167GATA2_19941826_ChIP-Seq_K562_Human0.93480112
168CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93464460
169NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92347399
170IKZF1_21737484_ChIP-ChIP_HCT116_Human0.91570456
171PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91468945
172SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90405311
173SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90405311
174GATA3_27048872_Chip-Seq_THYMUS_Human0.89706000
175TCF7_22412390_ChIP-Seq_EML_Mouse0.88272742
176P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88232904
177SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.88068700
178ELK4_26923725_Chip-Seq_MESODERM_Mouse0.87733150
179TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87686375
180SOX2_20726797_ChIP-Seq_SW620_Human0.86798206
181JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86246620
182ESR1_21235772_ChIP-Seq_MCF-7_Human0.85473265
183KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84521455
184YAP1_20516196_ChIP-Seq_MESCs_Mouse0.84127655
185CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83853267
186AR_21572438_ChIP-Seq_LNCaP_Human0.83667582
187ZNF263_19887448_ChIP-Seq_K562_Human0.83327139
188GATA1_19941827_ChIP-Seq_MEL_Mouse0.83195456

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.77853178
2MP0003300_gastrointestinal_ulcer3.63194756
3MP0000372_irregular_coat_pigmentation3.51924901
4MP0002102_abnormal_ear_morphology3.44995632
5MP0010234_abnormal_vibrissa_follicle3.19982988
6MP0002837_dystrophic_cardiac_calcinosis3.11735923
7MP0005058_abnormal_lysosome_morphology2.98865390
8MP0005248_abnormal_Harderian_gland2.84789108
9MP0003303_peritoneal_inflammation2.74786894
10MP0005671_abnormal_response_to2.64637049
11MP0006072_abnormal_retinal_apoptosis2.49231403
12MP0001835_abnormal_antigen_presentation2.43335309
13MP0003172_abnormal_lysosome_physiology2.35564472
14MP0005075_abnormal_melanosome_morpholog2.19635751
15MP0003436_decreased_susceptibility_to2.18136008
16MP0004510_myositis2.15326969
17MP0000604_amyloidosis2.09403010
18MP0000569_abnormal_digit_pigmentation2.08651524
19MP0006082_CNS_inflammation2.08161422
20MP0003252_abnormal_bile_duct2.00015759
21MP0005171_absent_coat_pigmentation1.99889083
22MP0004130_abnormal_muscle_cell1.99764233
23MP0004859_abnormal_synaptic_plasticity1.98079640
24MP0002938_white_spotting1.94826501
25MP0005646_abnormal_pituitary_gland1.93519231
26MP0010386_abnormal_urinary_bladder1.92376366
27MP0002163_abnormal_gland_morphology1.88874227
28MP0000427_abnormal_hair_cycle1.88529483
29MP0005253_abnormal_eye_physiology1.85937593
30MP0002160_abnormal_reproductive_system1.85851406
31MP0003632_abnormal_nervous_system1.82951217
32MP0004885_abnormal_endolymph1.81508691
33MP0002909_abnormal_adrenal_gland1.79320014
34MP0003329_amyloid_beta_deposits1.76440426
35MP0008058_abnormal_DNA_repair1.72799147
36MP0005379_endocrine/exocrine_gland_phen1.72488345
37MP0003690_abnormal_glial_cell1.70765614
38MP0005389_reproductive_system_phenotype1.70429891
39MP0003806_abnormal_nucleotide_metabolis1.68475302
40MP0009785_altered_susceptibility_to1.68164062
41MP0003566_abnormal_cell_adhesion1.67964224
42MP0003786_premature_aging1.66640542
43MP0001485_abnormal_pinna_reflex1.66129122
44MP0005174_abnormal_tail_pigmentation1.65905455
45MP0010678_abnormal_skin_adnexa1.64516964
46MP0002877_abnormal_melanocyte_morpholog1.64326646
47MP0004134_abnormal_chest_morphology1.63828089
48MP0000613_abnormal_salivary_gland1.61212478
49MP0005084_abnormal_gallbladder_morpholo1.56520343
50MP0005551_abnormal_eye_electrophysiolog1.56429393
51MP0003075_altered_response_to1.56084061
52MP0002876_abnormal_thyroid_physiology1.55305299
53MP0002419_abnormal_innate_immunity1.53780325
54MP0005408_hypopigmentation1.53731665
55MP0003724_increased_susceptibility_to1.52115982
56MP0005000_abnormal_immune_tolerance1.51189760
57MP0010307_abnormal_tumor_latency1.50785668
58MP0003183_abnormal_peptide_metabolism1.49888706
59MP0006054_spinal_hemorrhage1.48116274
60MP0003631_nervous_system_phenotype1.45689837
61MP0002928_abnormal_bile_duct1.44672834
62MP0004215_abnormal_myocardial_fiber1.44533442
63MP0003718_maternal_effect1.43586219
64MP0010030_abnormal_orbit_morphology1.43459382
65MP0003091_abnormal_cell_migration1.42283947
66MP0008872_abnormal_physiological_respon1.42135598
67MP0003633_abnormal_nervous_system1.39943137
68MP0003045_fibrosis1.39238716
69MP0005220_abnormal_exocrine_pancreas1.37857676
70MP0000516_abnormal_urinary_system1.37457338
71MP0005367_renal/urinary_system_phenotyp1.37457338
72MP0001533_abnormal_skeleton_physiology1.37013189
73MP0005166_decreased_susceptibility_to1.36897136
74MP0004858_abnormal_nervous_system1.36833190
75MP0000015_abnormal_ear_pigmentation1.31339416
76MP0000631_abnormal_neuroendocrine_gland1.28880589
77MP0008057_abnormal_DNA_replication1.26965852
78MP0003448_altered_tumor_morphology1.25366095
79MP0004147_increased_porphyrin_level1.25001438
80MP0000383_abnormal_hair_follicle1.24607237
81MP0006036_abnormal_mitochondrial_physio1.24044418
82MP0005387_immune_system_phenotype1.24027709
83MP0001790_abnormal_immune_system1.24027709
84MP0002138_abnormal_hepatobiliary_system1.23742972
85MP0003656_abnormal_erythrocyte_physiolo1.22836706
86MP0000013_abnormal_adipose_tissue1.22748983
87MP0002736_abnormal_nociception_after1.21209673
88MP0002452_abnormal_antigen_presenting1.19599650
89MP0008007_abnormal_cellular_replicative1.15991259
90MP0005535_abnormal_body_temperature1.14980142
91MP0002148_abnormal_hypersensitivity_rea1.14320980
92MP0004270_analgesia1.13946971
93MP0005464_abnormal_platelet_physiology1.12675393
94MP0000647_abnormal_sebaceous_gland1.12469334
95MP0005332_abnormal_amino_acid1.11725688
96MP0002254_reproductive_system_inflammat1.11568750
97MP0002734_abnormal_mechanical_nocicepti1.10558914
98MP0008775_abnormal_heart_ventricle1.10359220
99MP0004883_abnormal_blood_vessel1.10232188
100MP0003011_delayed_dark_adaptation1.09460305
101MP0002090_abnormal_vision1.08159958
102MP0002063_abnormal_learning/memory/cond1.07612028
103MP0003705_abnormal_hypodermis_morpholog1.06831868
104MP0010094_abnormal_chromosome_stability1.05978751
105MP0008438_abnormal_cutaneous_collagen1.05537197
106MP0003283_abnormal_digestive_organ1.04716142
107MP0002638_abnormal_pupillary_reflex1.04405902
108MP0002095_abnormal_skin_pigmentation1.03329903
109MP0002166_altered_tumor_susceptibility1.03100788
110MP0003121_genomic_imprinting1.02666537
111MP0002998_abnormal_bone_remodeling1.01298476
112MP0009780_abnormal_chondrocyte_physiolo1.01222405
113MP0002733_abnormal_thermal_nociception1.00693372
114MP0002971_abnormal_brown_adipose1.00453366
115MP0005636_abnormal_mineral_homeostasis1.00164184
116MP0001800_abnormal_humoral_immune0.99433314
117MP0001919_abnormal_reproductive_system0.98954386
118MP0009333_abnormal_splenocyte_physiolog0.98754595
119MP0005025_abnormal_response_to0.97159058
120MP0002272_abnormal_nervous_system0.96790472
121MP0001324_abnormal_eye_pigmentation0.96448028
122MP0001819_abnormal_immune_cell0.95969716
123MP0003635_abnormal_synaptic_transmissio0.95617332
124MP0005623_abnormal_meninges_morphology0.95537342
125MP0003136_yellow_coat_color0.95253005
126MP0001984_abnormal_olfaction0.95175698
127MP0000955_abnormal_spinal_cord0.94125983
128MP0002420_abnormal_adaptive_immunity0.93892577
129MP0005197_abnormal_uvea_morphology0.93424018
130MP0005645_abnormal_hypothalamus_physiol0.91417301
131MP0000371_diluted_coat_color0.90734920
132MP0001845_abnormal_inflammatory_respons0.90299185
133MP0009046_muscle_twitch0.90255485
134MP0004264_abnormal_extraembryonic_tissu0.90197365
135MP0001756_abnormal_urination0.89955566
136MP0005310_abnormal_salivary_gland0.89901662
137MP0004381_abnormal_hair_follicle0.89148590
138MP0005187_abnormal_penis_morphology0.88985591
139MP0003195_calcinosis0.88695656
140MP0002723_abnormal_immune_serum0.88474764
141MP0009764_decreased_sensitivity_to0.88354710
142MP0008877_abnormal_DNA_methylation0.88345950
143MP0002693_abnormal_pancreas_physiology0.88318115
144MP0001881_abnormal_mammary_gland0.88209458
145MP0001968_abnormal_touch/_nociception0.87749415
146MP0002006_tumorigenesis0.87611993
147MP0004811_abnormal_neuron_physiology0.87022177
148MP0001944_abnormal_pancreas_morphology0.86758179
149MP0003828_pulmonary_edema0.86701834
150MP0010352_gastrointestinal_tract_polyps0.86144526
151MP0003186_abnormal_redox_activity0.85612842
152MP0002933_joint_inflammation0.85472009
153MP0004947_skin_inflammation0.85419712
154MP0002751_abnormal_autonomic_nervous0.83700209
155MP0001970_abnormal_pain_threshold0.81995974
156MP0000534_abnormal_ureter_morphology0.81980428
157MP0003634_abnormal_glial_cell0.81735594
158MP0009697_abnormal_copulation0.81723047
159MP0002896_abnormal_bone_mineralization0.81449704
160MP0010155_abnormal_intestine_physiology0.80982453
161MP0004043_abnormal_pH_regulation0.80681746
162MP0005164_abnormal_response_to0.78834079
163MP0000465_gastrointestinal_hemorrhage0.78704312
164MP0001661_extended_life_span0.78573277
165MP0001764_abnormal_homeostasis0.77460420
166MP0004133_heterotaxia0.76515810
167MP0000653_abnormal_sex_gland0.76248468
168MP0009745_abnormal_behavioral_response0.76113399
169MP0005076_abnormal_cell_differentiation0.75740452
170MP0006035_abnormal_mitochondrial_morpho0.74690865
171MP0003137_abnormal_impulse_conducting0.74122006
172MP0010630_abnormal_cardiac_muscle0.73002287
173MP0001929_abnormal_gametogenesis0.72455731
174MP0003937_abnormal_limbs/digits/tail_de0.72320116
175MP0000230_abnormal_systemic_arterial0.71760150
176MP0005395_other_phenotype0.70325009
177MP0001486_abnormal_startle_reflex0.68944267
178MP0010329_abnormal_lipoprotein_level0.68193280
179MP0002277_abnormal_respiratory_mucosa0.67677773
180MP0001765_abnormal_ion_homeostasis0.66678483
181MP0004484_altered_response_of0.66241636

Predicted human phenotypes

RankGene SetZ-score
1Facial diplegia (HP:0001349)8.21823837
2Progressive inability to walk (HP:0002505)7.77955036
3Conjunctival hamartoma (HP:0100780)5.05929809
4Ragged-red muscle fibers (HP:0003200)4.51341900
5Hamartoma of the eye (HP:0010568)4.19563502
6Increased cerebral lipofuscin (HP:0011813)3.89849001
7Inability to walk (HP:0002540)3.75913265
8Failure to thrive in infancy (HP:0001531)3.58910776
9Increased neuronal autofluorescent lipopigment (HP:0002074)3.42945111
10Pancreatic cysts (HP:0001737)3.40023741
11Volvulus (HP:0002580)3.39567870
12EMG: myopathic abnormalities (HP:0003458)3.28979903
13Methylmalonic acidemia (HP:0002912)3.28165819
14Abnormality of the heme biosynthetic pathway (HP:0010472)3.20885819
15Absent frontal sinuses (HP:0002688)3.16486210
16Neoplasm of the adrenal cortex (HP:0100641)3.13636128
17Pancreatic fibrosis (HP:0100732)3.08753212
18Hypothermia (HP:0002045)3.05748079
19Delayed gross motor development (HP:0002194)3.05578816
20Furrowed tongue (HP:0000221)3.03901007
21Meningioma (HP:0002858)3.03299133
22Abnormal pancreas size (HP:0012094)3.02095441
23Optic neuritis (HP:0100653)2.95426696
24Retrobulbar optic neuritis (HP:0100654)2.95426696
25Obsessive-compulsive behavior (HP:0000722)2.83360613
26Abolished electroretinogram (ERG) (HP:0000550)2.82173080
27Open mouth (HP:0000194)2.81808699
28True hermaphroditism (HP:0010459)2.78000763
29Stereotypic behavior (HP:0000733)2.75921822
30Hyperinsulinemic hypoglycemia (HP:0000825)2.74088233
31Generalized amyotrophy (HP:0003700)2.72984118
32Orchitis (HP:0100796)2.71953414
33Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.70300668
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.67321482
35Decreased activity of mitochondrial respiratory chain (HP:0008972)2.67321482
36Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.66542481
37Periodontitis (HP:0000704)2.62553390
38Urinary glycosaminoglycan excretion (HP:0003541)2.61733444
39Mucopolysacchariduria (HP:0008155)2.61733444
40Aplasia/Hypoplasia of the fovea (HP:0008060)2.58732486
41Hypoplasia of the fovea (HP:0007750)2.58732486
42Gowers sign (HP:0003391)2.56943182
43Hypoglycemic seizures (HP:0002173)2.55398178
44Adenoma sebaceum (HP:0009720)2.54527936
45Angiofibromas (HP:0010615)2.54527936
46Bone cyst (HP:0012062)2.52879218
47Progressive macrocephaly (HP:0004481)2.51936059
48Disinhibition (HP:0000734)2.51503216
49Annular pancreas (HP:0001734)2.51319564
50Inappropriate behavior (HP:0000719)2.50713410
51Neoplasm of the adrenal gland (HP:0100631)2.50269067
52Abnormality of vitamin B metabolism (HP:0004340)2.50261393
53Thyroiditis (HP:0100646)2.49165372
54Febrile seizures (HP:0002373)2.48136810
55Myositis (HP:0100614)2.47924435
56Congenital sensorineural hearing impairment (HP:0008527)2.46108757
57Hypochromic microcytic anemia (HP:0004840)2.44105534
58Abnormality of mucopolysaccharide metabolism (HP:0011020)2.44062107
59Abnormality of polysaccharide metabolism (HP:0011012)2.44062107
60Abnormality of glycosaminoglycan metabolism (HP:0004371)2.44062107
61Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.43875727
62Methylmalonic aciduria (HP:0012120)2.43744366
63Intellectual disability, progressive (HP:0006887)2.43380283
64Skin nodule (HP:0200036)2.43359532
65Nephronophthisis (HP:0000090)2.42792037
66Pendular nystagmus (HP:0012043)2.41992018
67Hypoglycemic coma (HP:0001325)2.41691405
68Abnormality of midbrain morphology (HP:0002418)2.38275735
69Molar tooth sign on MRI (HP:0002419)2.38275735
70Ketoacidosis (HP:0001993)2.38251139
71Short tibia (HP:0005736)2.35508109
72Intestinal atresia (HP:0011100)2.35131560
73Congenital stationary night blindness (HP:0007642)2.33747037
74Supranuclear gaze palsy (HP:0000605)2.32825807
75Dysostosis multiplex (HP:0000943)2.32767844
76Abnormality of the periventricular white matter (HP:0002518)2.30386634
77Aplasia/Hypoplasia of the tibia (HP:0005772)2.28979476
78Adrenal hypoplasia (HP:0000835)2.28882265
79Hematochezia (HP:0002573)2.28520128
80Abnormality of chromosome stability (HP:0003220)2.28439235
81Tongue fasciculations (HP:0001308)2.27868391
82Increased CSF lactate (HP:0002490)2.26941533
83Congenital, generalized hypertrichosis (HP:0004540)2.25611451
84Gaze-evoked nystagmus (HP:0000640)2.24067185
85Mitochondrial inheritance (HP:0001427)2.21603190
86Hepatic necrosis (HP:0002605)2.21388970
87Abnormality of the renal cortex (HP:0011035)2.20917172
88Abnormality of aspartate family amino acid metabolism (HP:0010899)2.20610460
89Abnormality of the frontal sinuses (HP:0002687)2.20233377
90Goiter (HP:0000853)2.19996382
91Decreased central vision (HP:0007663)2.18636631
92Vacuolated lymphocytes (HP:0001922)2.18574692
93Osteomalacia (HP:0002749)2.13613778
94Recurrent bacterial skin infections (HP:0005406)2.13074788
95Hypomagnesemia (HP:0002917)2.13035342
96Subacute progressive viral hepatitis (HP:0006572)2.12542493
97Abnormality of the vitamin B12 metabolism (HP:0004341)2.12170314
98Abnormality of methionine metabolism (HP:0010901)2.12167147
99Abnormality of liposaccharide metabolism (HP:0010968)2.11429897
100Abnormality of glycosphingolipid metabolism (HP:0004343)2.11429897
101Abnormality of glycolipid metabolism (HP:0010969)2.11429897
102Acute necrotizing encephalopathy (HP:0006965)2.11011958
103Abnormality of the fovea (HP:0000493)2.10180961
104Cortical dysplasia (HP:0002539)2.09532135
105Hepatocellular necrosis (HP:0001404)2.06443306
106Weak cry (HP:0001612)2.05532554
107Abnormality of the renal medulla (HP:0100957)2.04941111
108Gingivitis (HP:0000230)2.04836585
109Pathologic fracture (HP:0002756)2.04827418
110Recurrent abscess formation (HP:0002722)2.04071057
111Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.03983656
112Eczematoid dermatitis (HP:0000976)2.03683784
113Cerebral aneurysm (HP:0004944)2.03377527
114Large for gestational age (HP:0001520)2.02264167
115Decreased electroretinogram (ERG) amplitude (HP:0000654)2.01542039
116Aplasia/hypoplasia of the uterus (HP:0008684)2.00943325
117Loss of speech (HP:0002371)2.00906022
118Buphthalmos (HP:0000557)2.00795152
119Hyperglycemia (HP:0003074)2.00511928
120Aplasia/Hypoplasia of the uvula (HP:0010293)2.00202579
121Attenuation of retinal blood vessels (HP:0007843)1.99566764
122Spondylolisthesis (HP:0003302)1.97823021
123Abnormal rod and cone electroretinograms (HP:0008323)1.97407370
124Abnormality of proline metabolism (HP:0010907)1.97367700
125Hydroxyprolinuria (HP:0003080)1.97367700
126Acute encephalopathy (HP:0006846)1.97230464
127Symptomatic seizures (HP:0011145)1.96955170
128Increased corneal curvature (HP:0100692)1.96624766
129Keratoconus (HP:0000563)1.96624766
130Action tremor (HP:0002345)1.95855189
131Arterial thrombosis (HP:0004420)1.95536395
132Melanoma (HP:0002861)1.94999746
133Asplenia (HP:0001746)1.94560020
134Increased circulating renin level (HP:0000848)1.94068106
135Hypoplastic pelvis (HP:0008839)1.92998494
136Abnormality of calcium-phosphate metabolism (HP:0100530)1.92840828
137Abnormality of endocrine pancreas physiology (HP:0012093)1.92482271
138Abnormality of the pancreatic islet cells (HP:0006476)1.92482271
139Severe visual impairment (HP:0001141)1.91104227
140Patchy hypopigmentation of hair (HP:0011365)1.91053584
141Focal seizures (HP:0007359)1.90705706
142Medial flaring of the eyebrow (HP:0010747)1.90678444
143Small hand (HP:0200055)1.89555562
144Agitation (HP:0000713)1.89323314
145Striae distensae (HP:0001065)1.88333438
146Aplasia/Hypoplasia of the spleen (HP:0010451)1.87830797
147Cutaneous melanoma (HP:0012056)1.87292027
148Meckel diverticulum (HP:0002245)1.85905526
149Abnormality of the ileum (HP:0001549)1.85897491
150Papilledema (HP:0001085)1.85756129
151Recurrent gram-negative bacterial infections (HP:0005420)1.85345638
152Macroorchidism (HP:0000053)1.84816716
153Breast carcinoma (HP:0003002)1.83021946
154Short 1st metacarpal (HP:0010034)1.82977454
155Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.82977454
156Tetraparesis (HP:0002273)1.82902724
157Systemic lupus erythematosus (HP:0002725)1.82675060
158Muscle fibrillation (HP:0010546)1.81556064
159Hypoplasia of the uterus (HP:0000013)1.80505175
160Hemiparesis (HP:0001269)1.80349705
161Disproportionate short-trunk short stature (HP:0003521)1.80093489
162Pancreatic islet-cell hyperplasia (HP:0004510)1.79615769
163Aplasia/Hypoplasia of the tongue (HP:0010295)1.79480213
164Abnormal drinking behavior (HP:0030082)1.79340229
165Polydipsia (HP:0001959)1.79340229
166Cavernous hemangioma (HP:0001048)1.77177885
167Abnormality of dentin (HP:0010299)1.76970801
168Metaphyseal dysplasia (HP:0100255)1.75277665
169Palpitations (HP:0001962)1.74881930
170Abnormality of the proximal phalanges of the hand (HP:0009834)1.74694296
171Mitral stenosis (HP:0001718)1.73659226
172Intestinal polyposis (HP:0200008)1.73624096
173Aplasia/Hypoplasia of the macula (HP:0008059)1.72585397
174Apathy (HP:0000741)1.72242862
175Albinism (HP:0001022)1.71751730
176Renal cortical cysts (HP:0000803)1.71082379
177Abnormality of the basal ganglia (HP:0002134)1.70917631
178Peritonitis (HP:0002586)1.70209277
179Abnormality of the preputium (HP:0100587)1.70112127
180Arterial tortuosity (HP:0005116)1.69367932
181Irritability (HP:0000737)1.68705409
182Autoimmune thrombocytopenia (HP:0001973)1.68254308
183Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.68040245
184Smooth philtrum (HP:0000319)1.67665386
185Hypercholesterolemia (HP:0003124)1.66623679
186Protruding tongue (HP:0010808)1.65638787
187Interstitial pulmonary disease (HP:0006530)1.64848269
188Exotropia (HP:0000577)1.62400000
189Mutism (HP:0002300)1.61151844
190Diminished motivation (HP:0000745)1.59860485
191Glomerulopathy (HP:0100820)1.59709457
192Long toe (HP:0010511)1.59584340
193Pulmonary infiltrates (HP:0002113)1.59317869
194Upper motor neuron abnormality (HP:0002127)1.59300918
195Vasculitis (HP:0002633)1.57943203
196Hyperparathyroidism (HP:0000843)1.56435114
197Akinesia (HP:0002304)1.56131376
198Lower limb amyotrophy (HP:0007210)1.55946741

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.88458779
2MST43.56708070
3FGFR33.27577402
4TRIM283.22782047
5EIF2AK32.86672565
6ACVR1B2.77505712
7MAP3K122.76142626
8PIK3CA2.66177230
9BMPR1B2.48334385
10MKNK22.27835101
11SCYL22.17740884
12MARK12.08967635
13GRK12.08945782
14SIK12.08467073
15PKN22.06353785
16EIF2AK12.00173313
17FGFR21.98358125
18MAP4K21.94972729
19TNIK1.88162058
20MAP3K91.87344655
21RIPK41.81927736
22STK391.79121739
23MAP3K141.78117668
24ADRBK21.75641222
25JAK11.74204086
26TRIB31.73314994
27DMPK1.71954440
28SGK31.66865613
29PLK31.66097935
30DYRK1A1.65550708
31DYRK1B1.61577988
32CAMKK21.61335033
33NUAK11.60327131
34TBK11.53743907
35TYK21.51565717
36ERBB31.49688856
37OXSR11.49408882
38BUB11.49386370
39KSR21.47156806
40BRSK21.46477634
41TAF11.40437868
42BCR1.36362950
43STK38L1.35528884
44NTRK11.35212806
45SIK31.33370518
46MKNK11.32768985
47PLK21.30834447
48RET1.30206334
49CSNK1G11.29689704
50MAP3K71.26391924
51TTN1.26388432
52PRKCH1.26193313
53WNK31.25566379
54CAMKK11.25286130
55WEE11.25033766
56STK31.23635893
57CSF1R1.22235194
58ZAK1.22166583
59PTK61.21591179
60PDGFRA1.17114498
61RIPK11.14072787
62PDK11.12581729
63CASK1.12046354
64LMTK21.11369560
65STK161.11264751
66NLK1.10561421
67CDK61.09907480
68BLK1.09362051
69RAF11.07443957
70PDGFRB1.06546631
71SGK21.06218863
72SIK21.05344450
73PINK11.01533209
74SGK2230.99810992
75SGK4940.99810992
76IKBKE0.99792187
77PDPK10.99317231
78JAK30.96728808
79MAPK130.93484784
80PRKCE0.92429785
81NTRK30.90820664
82MINK10.90559032
83UHMK10.90533732
84EEF2K0.88961473
85ILK0.88502081
86INSRR0.87442242
87TRPM70.86919423
88PAK60.85724711
89EIF2AK20.85588514
90SYK0.84202401
91TSSK60.83826327
92MAP3K20.83671376
93MAP2K10.82606501
94JAK20.81139897
95FLT30.80696747
96VRK20.79941854
97FES0.79224155
98BMPR20.78934599
99AKT30.77896550
100VRK10.76047710
101TGFBR20.75456927
102HIPK20.74580135
103EPHA30.74263879
104PHKG20.72421077
105PHKG10.72421077
106NEK90.71982534
107PTK2B0.71243361
108PLK40.70912386
109CSNK1G20.70696189
110GRK50.70489718
111HCK0.69993247
112STK380.69186833
113MAP4K10.69064149
114MAP3K40.68930610
115ADRBK10.68723676
116NEK10.68712165
117EPHB20.68524932
118CDK50.66679850
119FYN0.64311997
120PLK10.63481739
121GRK70.61719863
122PDK20.61519543
123LATS20.61300965
124EGFR0.60147628
125PRKD10.59809247
126MOS0.59163376
127TEC0.58392876
128TAOK10.57985476
129CHUK0.57438713
130KSR10.56553940
131PRKCG0.54908136
132WNK40.54491152
133PTK20.53989242
134PAK40.53618206
135FER0.52477675
136TIE10.52300014
137RPS6KA20.51475909
138MAPK120.51358993
139ZAP700.50848329
140MAP2K40.50584138
141CSNK1A1L0.49719973
142TAOK30.49626128
143FGR0.49368380
144EPHB10.49198537
145KIT0.48000843
146PRKD30.47726104
147PAK30.47352708
148CSK0.46671580
149TGFBR10.42699546
150CSNK1G30.42272601
151PRKCI0.42083422
152IKBKB0.41664989
153PRKAA10.40647776
154STK100.39779072
155PRKCQ0.39772899
156ABL10.39326078
157LRRK20.38837990
158SGK10.38605218
159GSK3A0.38027379
160ATM0.37789415
161CSNK1A10.37753654
162TXK0.37720412
163DAPK20.36518992
164MAPKAPK50.34807485
165NME20.34610292
166MAP2K60.32734447
167STK240.32508175
168BRSK10.31293158
169TLK10.30058285
170IGF1R0.29925195
171CSNK1D0.29274504
172ATR0.29039632
173MELK0.28963696
174SRPK10.28082631
175CAMK2A0.26962404
176MYLK0.26409194
177STK40.26211147
178ERBB40.25193962

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.05215900
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.98347370
3Proteasome_Homo sapiens_hsa030502.91458766
4Sulfur metabolism_Homo sapiens_hsa009202.68110717
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.47277957
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.38408753
7Leishmaniasis_Homo sapiens_hsa051402.18032999
8Propanoate metabolism_Homo sapiens_hsa006402.17501559
9Non-homologous end-joining_Homo sapiens_hsa034502.13973607
10Homologous recombination_Homo sapiens_hsa034402.07807311
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.02391812
12Vitamin B6 metabolism_Homo sapiens_hsa007501.96528727
13Butanoate metabolism_Homo sapiens_hsa006501.92859670
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.81836252
15Fatty acid elongation_Homo sapiens_hsa000621.79437198
16Fanconi anemia pathway_Homo sapiens_hsa034601.79084316
17Basal transcription factors_Homo sapiens_hsa030221.75516760
18Oxidative phosphorylation_Homo sapiens_hsa001901.74294612
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.72818090
20Phagosome_Homo sapiens_hsa041451.71984501
21Lysosome_Homo sapiens_hsa041421.68867811
22Nitrogen metabolism_Homo sapiens_hsa009101.68249137
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65966990
24Phototransduction_Homo sapiens_hsa047441.65825032
25Type I diabetes mellitus_Homo sapiens_hsa049401.63358041
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.62525192
27Osteoclast differentiation_Homo sapiens_hsa043801.61388711
28Synaptic vesicle cycle_Homo sapiens_hsa047211.57110574
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56761564
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54674224
31Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.54251026
32Rheumatoid arthritis_Homo sapiens_hsa053231.52768520
33Graft-versus-host disease_Homo sapiens_hsa053321.51905112
34RNA degradation_Homo sapiens_hsa030181.51413871
35Tryptophan metabolism_Homo sapiens_hsa003801.44204631
36Salmonella infection_Homo sapiens_hsa051321.40373267
37RNA polymerase_Homo sapiens_hsa030201.39339987
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.36296721
39Tuberculosis_Homo sapiens_hsa051521.33215785
40Toxoplasmosis_Homo sapiens_hsa051451.32149771
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.30895816
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29845147
43Collecting duct acid secretion_Homo sapiens_hsa049661.29468861
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29456503
45Selenocompound metabolism_Homo sapiens_hsa004501.28317154
46Non-small cell lung cancer_Homo sapiens_hsa052231.26262029
47Peroxisome_Homo sapiens_hsa041461.24290213
48Parkinsons disease_Homo sapiens_hsa050121.21503224
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21346388
50Regulation of autophagy_Homo sapiens_hsa041401.21245951
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.20932511
52Chronic myeloid leukemia_Homo sapiens_hsa052201.20414096
53Endometrial cancer_Homo sapiens_hsa052131.19444074
54NF-kappa B signaling pathway_Homo sapiens_hsa040641.19235114
55Neurotrophin signaling pathway_Homo sapiens_hsa047221.18072196
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16275777
57Amoebiasis_Homo sapiens_hsa051461.14943973
58Primary bile acid biosynthesis_Homo sapiens_hsa001201.11958920
59Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11748924
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11661948
61Pertussis_Homo sapiens_hsa051331.10521152
62Ether lipid metabolism_Homo sapiens_hsa005651.10454088
63Vibrio cholerae infection_Homo sapiens_hsa051101.10383352
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09666002
65Legionellosis_Homo sapiens_hsa051341.09366495
66Staphylococcus aureus infection_Homo sapiens_hsa051501.08616404
67Malaria_Homo sapiens_hsa051441.08506025
68Chemical carcinogenesis_Homo sapiens_hsa052041.08273824
69Retinol metabolism_Homo sapiens_hsa008301.08238935
70Caffeine metabolism_Homo sapiens_hsa002321.08192700
71Cholinergic synapse_Homo sapiens_hsa047251.07426928
72Type II diabetes mellitus_Homo sapiens_hsa049301.07389988
73Measles_Homo sapiens_hsa051621.06480616
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04749787
75Chemokine signaling pathway_Homo sapiens_hsa040621.04354898
76B cell receptor signaling pathway_Homo sapiens_hsa046621.03655976
77Glutathione metabolism_Homo sapiens_hsa004801.02608849
78mTOR signaling pathway_Homo sapiens_hsa041501.02462123
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.02232669
80Mismatch repair_Homo sapiens_hsa034301.00244280
81Viral myocarditis_Homo sapiens_hsa054160.98682314
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.97939115
83Pancreatic cancer_Homo sapiens_hsa052120.97794584
84TNF signaling pathway_Homo sapiens_hsa046680.96397185
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96185541
86Prolactin signaling pathway_Homo sapiens_hsa049170.95916480
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95489298
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94506004
89Linoleic acid metabolism_Homo sapiens_hsa005910.93063205
90Insulin resistance_Homo sapiens_hsa049310.91572424
91beta-Alanine metabolism_Homo sapiens_hsa004100.91075765
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90502311
93p53 signaling pathway_Homo sapiens_hsa041150.89637858
94Inositol phosphate metabolism_Homo sapiens_hsa005620.87657721
95Influenza A_Homo sapiens_hsa051640.85868285
96Antigen processing and presentation_Homo sapiens_hsa046120.85834876
97Allograft rejection_Homo sapiens_hsa053300.85050849
98Circadian rhythm_Homo sapiens_hsa047100.83952780
99Oocyte meiosis_Homo sapiens_hsa041140.83702027
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83504806
101One carbon pool by folate_Homo sapiens_hsa006700.83284582
102Steroid biosynthesis_Homo sapiens_hsa001000.83112453
103Glioma_Homo sapiens_hsa052140.83028338
104Platelet activation_Homo sapiens_hsa046110.82587259
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80177731
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80147973
107Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79399276
108African trypanosomiasis_Homo sapiens_hsa051430.79127231
109Endocytosis_Homo sapiens_hsa041440.79051763
110RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78107139
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.77730239
112Shigellosis_Homo sapiens_hsa051310.77701739
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77576411
114Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77247464
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76584462
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75057185
117RNA transport_Homo sapiens_hsa030130.73996059
118Drug metabolism - other enzymes_Homo sapiens_hsa009830.73938327
119ErbB signaling pathway_Homo sapiens_hsa040120.73658420
120Cysteine and methionine metabolism_Homo sapiens_hsa002700.73188496
121Olfactory transduction_Homo sapiens_hsa047400.73154772
122Intestinal immune network for IgA production_Homo sapiens_hsa046720.72949419
123Proteoglycans in cancer_Homo sapiens_hsa052050.72235997
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71142582
125Nucleotide excision repair_Homo sapiens_hsa034200.70723291
126Purine metabolism_Homo sapiens_hsa002300.70719627
127T cell receptor signaling pathway_Homo sapiens_hsa046600.69740619
128Alzheimers disease_Homo sapiens_hsa050100.69328474
129Mineral absorption_Homo sapiens_hsa049780.68600055
130Taste transduction_Homo sapiens_hsa047420.68573853
131Steroid hormone biosynthesis_Homo sapiens_hsa001400.68518192
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68126053
133Morphine addiction_Homo sapiens_hsa050320.67594910
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67028357
135Renal cell carcinoma_Homo sapiens_hsa052110.65357305
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65249131
137Colorectal cancer_Homo sapiens_hsa052100.65119247
138Insulin signaling pathway_Homo sapiens_hsa049100.64955935
139Prion diseases_Homo sapiens_hsa050200.64479061
140Dorso-ventral axis formation_Homo sapiens_hsa043200.64077694
141Fatty acid degradation_Homo sapiens_hsa000710.64017682
142Circadian entrainment_Homo sapiens_hsa047130.63708738
143Apoptosis_Homo sapiens_hsa042100.63015481
144Hepatitis B_Homo sapiens_hsa051610.62438707
145Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61774699
146Long-term potentiation_Homo sapiens_hsa047200.61715120
147Insulin secretion_Homo sapiens_hsa049110.61503979
148Adherens junction_Homo sapiens_hsa045200.61222110
149Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61037719
150Metabolic pathways_Homo sapiens_hsa011000.59452245
151Renin secretion_Homo sapiens_hsa049240.59408149
152Melanoma_Homo sapiens_hsa052180.59157162
153VEGF signaling pathway_Homo sapiens_hsa043700.57465729
154Focal adhesion_Homo sapiens_hsa045100.57395821
155GABAergic synapse_Homo sapiens_hsa047270.57320080
156Vitamin digestion and absorption_Homo sapiens_hsa049770.57043512
157Choline metabolism in cancer_Homo sapiens_hsa052310.56764990
158MAPK signaling pathway_Homo sapiens_hsa040100.56029137
159Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55856640
160Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55721149
161Serotonergic synapse_Homo sapiens_hsa047260.55603472
162Hepatitis C_Homo sapiens_hsa051600.55572747
163Estrogen signaling pathway_Homo sapiens_hsa049150.55313843
164Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54964738
165Huntingtons disease_Homo sapiens_hsa050160.54901546
166Dopaminergic synapse_Homo sapiens_hsa047280.54134800
167Fatty acid metabolism_Homo sapiens_hsa012120.53858922
168Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53522759
169Cocaine addiction_Homo sapiens_hsa050300.53340185
170Adipocytokine signaling pathway_Homo sapiens_hsa049200.51798196
171Acute myeloid leukemia_Homo sapiens_hsa052210.51328774
172TGF-beta signaling pathway_Homo sapiens_hsa043500.50201374
173Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49096663
174Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48680651
175Folate biosynthesis_Homo sapiens_hsa007900.48166955
176Glycerolipid metabolism_Homo sapiens_hsa005610.46653714
177N-Glycan biosynthesis_Homo sapiens_hsa005100.45102386
178Pyruvate metabolism_Homo sapiens_hsa006200.44279508
179Pyrimidine metabolism_Homo sapiens_hsa002400.43909566
180Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43767372
181Nicotine addiction_Homo sapiens_hsa050330.43231596
182Starch and sucrose metabolism_Homo sapiens_hsa005000.39739279
183ABC transporters_Homo sapiens_hsa020100.39588816
184Arachidonic acid metabolism_Homo sapiens_hsa005900.38056834
185Hedgehog signaling pathway_Homo sapiens_hsa043400.35188778
186Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34667187

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