BRPF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a bromodomain, PHD finger and chromo/Tudor-related Pro-Trp-Trp-Pro (PWWP) domain containing protein. The encoded protein is a component of the MOZ/MORF histone acetyltransferase complexes which function as a transcriptional regulators. This protein binds to the catalytic MYST domains of the MOZ and MORF proteins and may play a role in stimulating acetyltransferase and transcriptional activity of the complex. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of histone H3-K27 methylation (GO:0061085)7.96862104
2presynaptic membrane assembly (GO:0097105)7.71633659
3postsynaptic membrane organization (GO:0001941)7.02281282
4ribosomal small subunit biogenesis (GO:0042274)6.56087288
5viral transcription (GO:0019083)6.52830667
6presynaptic membrane organization (GO:0097090)6.21471399
7translational termination (GO:0006415)6.13971250
8interferon-gamma production (GO:0032609)5.59741368
9Golgi to endosome transport (GO:0006895)5.56218593
10negative regulation of erythrocyte differentiation (GO:0045647)5.52286690
11protein heterotetramerization (GO:0051290)5.34927664
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.30326851
13cotranslational protein targeting to membrane (GO:0006613)5.27760412
14generation of neurons (GO:0048699)5.25733294
15protein targeting to ER (GO:0045047)5.24849973
16mature B cell differentiation (GO:0002335)5.06917716
17establishment of protein localization to endoplasmic reticulum (GO:0072599)5.03033067
18protein localization to endoplasmic reticulum (GO:0070972)4.95567973
19regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)4.91341389
20ribosomal large subunit biogenesis (GO:0042273)4.90334482
21translational elongation (GO:0006414)4.69080775
22regulation of metalloenzyme activity (GO:0048552)4.68605981
23cellular protein complex disassembly (GO:0043624)4.53965810
24viral life cycle (GO:0019058)4.49154813
25nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.36489492
26histone H3-K36 demethylation (GO:0070544)4.34927116
27ribosomal small subunit assembly (GO:0000028)4.25310053
28regulation of NFAT protein import into nucleus (GO:0051532)4.04697412
29short-term memory (GO:0007614)4.03381712
30translational initiation (GO:0006413)4.03113213
31response to folic acid (GO:0051593)4.02713755
32nuclear pore complex assembly (GO:0051292)4.00556573
33positive regulation of dendritic spine development (GO:0060999)3.93888984
34positive regulation of gamma-delta T cell activation (GO:0046645)3.92970590
35protein complex disassembly (GO:0043241)3.86851698
36response to peptidoglycan (GO:0032494)3.77219284
37response to muramyl dipeptide (GO:0032495)3.74973849
38maturation of SSU-rRNA (GO:0030490)3.74547593
39lymphoid progenitor cell differentiation (GO:0002320)3.73837580
40mitotic chromosome condensation (GO:0007076)3.73325101
41regulation of stem cell maintenance (GO:2000036)3.69930436
42cranial nerve morphogenesis (GO:0021602)3.66162618
43neuron cell-cell adhesion (GO:0007158)3.61875013
44macromolecular complex disassembly (GO:0032984)3.60416636
45negative regulation of histone methylation (GO:0031061)3.60103448
46facial nerve structural organization (GO:0021612)3.59642135
47neurotransmitter-gated ion channel clustering (GO:0072578)3.56238498
48omega-hydroxylase P450 pathway (GO:0097267)3.55204489
49negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.53469560
50negative regulation of T-helper cell differentiation (GO:0045623)3.53469560
51spliceosomal tri-snRNP complex assembly (GO:0000244)3.53222883
52histone lysine demethylation (GO:0070076)3.45983643
53histone demethylation (GO:0016577)3.44096977
54regulation of pigment cell differentiation (GO:0050932)3.41517710
55regulation of RNA export from nucleus (GO:0046831)3.40797950
56protein targeting to membrane (GO:0006612)3.40544069
57positive regulation of neurotransmitter secretion (GO:0001956)3.39580111
58regulation of ruffle assembly (GO:1900027)3.39348055
59positive regulation of cellular amine metabolic process (GO:0033240)3.37815503
60pattern specification involved in kidney development (GO:0061004)3.33670242
61regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.33000045
62tRNA modification (GO:0006400)3.28591846
63positive regulation by symbiont of host defense response (GO:0052509)3.28460842
64modulation by symbiont of host defense response (GO:0052031)3.28460842
65modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.28460842
66modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.28460842
67positive regulation by organism of defense response of other organism involved in symbiotic interact3.28460842
68modulation by symbiont of host immune response (GO:0052553)3.28460842
69positive regulation of synaptic transmission, GABAergic (GO:0032230)3.28188385
70regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.27699997
71melanin metabolic process (GO:0006582)3.26887923
723-UTR-mediated mRNA stabilization (GO:0070935)3.25469900
73negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.24243383
74membrane assembly (GO:0071709)3.24023019
75positive regulation of B cell differentiation (GO:0045579)3.22695014
76DNA ligation (GO:0006266)3.19791672
77nuclear pore organization (GO:0006999)3.18685907
78cellular extravasation (GO:0045123)3.14793842
79telomere maintenance via semi-conservative replication (GO:0032201)3.12661424
80negative regulation of alpha-beta T cell differentiation (GO:0046639)3.12262174
81positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.10119939
82positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.06593283
83sphingoid metabolic process (GO:0046519)3.05770355
84positive regulation of systemic arterial blood pressure (GO:0003084)3.05648370
85protein dealkylation (GO:0008214)3.02526871
86protein demethylation (GO:0006482)3.02526871
87pore complex assembly (GO:0046931)3.01292231
88negative regulation of viral release from host cell (GO:1902187)3.01027710
89regulation of histone H3-K9 methylation (GO:0051570)2.99497488
90mRNA catabolic process (GO:0006402)2.99465932
91nuclear-transcribed mRNA catabolic process (GO:0000956)2.98671737
92embryonic process involved in female pregnancy (GO:0060136)2.98382052
93regulation of nucleobase-containing compound transport (GO:0032239)2.98345682
94negative regulation of metanephros development (GO:0072217)2.98020431
95mesonephros development (GO:0001823)2.96867449
96positive regulation of natural killer cell mediated immunity (GO:0002717)2.96671863
97positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.96671863
98negative regulation of inclusion body assembly (GO:0090084)2.96265741
99protein localization to synapse (GO:0035418)2.94919170
100positive regulation of protein kinase C signaling (GO:0090037)2.91004980
101developmental pigmentation (GO:0048066)2.90345383
102regulation of T-helper 2 cell differentiation (GO:0045628)2.88808981
103DNA damage response, detection of DNA damage (GO:0042769)2.88540584
104regulation of natural killer cell mediated immunity (GO:0002715)2.88511021
105regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.88511021
106mRNA stabilization (GO:0048255)2.87986132
107RNA stabilization (GO:0043489)2.87986132
108regulation of gamma-delta T cell activation (GO:0046643)2.87984353
109proteasome assembly (GO:0043248)2.87348674
110regulation of T-helper 1 cell differentiation (GO:0045625)2.86414444
111peptidyl-threonine dephosphorylation (GO:0035970)2.86359593
112response to laminar fluid shear stress (GO:0034616)2.84124719
113positive thymic T cell selection (GO:0045059)2.83484105
114DNA unwinding involved in DNA replication (GO:0006268)2.82781984
115regulation of chromatin binding (GO:0035561)2.81485527
116mannose metabolic process (GO:0006013)2.81382344
117dosage compensation (GO:0007549)2.79624177
118regulation of leukocyte degranulation (GO:0043300)2.78854522
119intracellular estrogen receptor signaling pathway (GO:0030520)2.78249473
120negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.77197103
121regulation of early endosome to late endosome transport (GO:2000641)2.76471853
122cellular response to exogenous dsRNA (GO:0071360)2.76028793
123regulation of mammary gland epithelial cell proliferation (GO:0033599)2.75905645
124positive regulation of dendritic spine morphogenesis (GO:0061003)2.75804712
125RNA catabolic process (GO:0006401)2.75069886
126DNA replication initiation (GO:0006270)2.74574415
127positive regulation of membrane potential (GO:0045838)2.72408514
128histone H3-K4 methylation (GO:0051568)2.72326852
129nephron tubule formation (GO:0072079)2.71884662
130adult heart development (GO:0007512)2.71678407
131histone H3-K9 demethylation (GO:0033169)2.71464125
132regulation of gamma-delta T cell differentiation (GO:0045586)2.70700445
133cranial nerve structural organization (GO:0021604)2.69146489
134neuronal action potential propagation (GO:0019227)2.68170700
135regulation of type I interferon-mediated signaling pathway (GO:0060338)2.67714864
136regulation of mast cell degranulation (GO:0043304)2.66827962
137thymic T cell selection (GO:0045061)2.66003965
138positive regulation of defense response to virus by host (GO:0002230)2.65952505
139positive regulation of synapse assembly (GO:0051965)2.65755928
140negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.65307346
141negative regulation of cell killing (GO:0031342)2.65307346
142interferon-gamma secretion (GO:0072643)2.64664808
143modulation by virus of host process (GO:0019054)2.64464257
144translation (GO:0006412)2.62969343
145regulation of B cell receptor signaling pathway (GO:0050855)2.60970835
146DNA synthesis involved in DNA repair (GO:0000731)2.60786181
147regulation of histone methylation (GO:0031060)2.60435882
148negative regulation of leukocyte chemotaxis (GO:0002689)2.59184523
149modulation by symbiont of host cellular process (GO:0044068)2.59110630
150respiratory chain complex IV assembly (GO:0008535)2.59093076
151mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.58928556
152protein K63-linked deubiquitination (GO:0070536)2.58500133
153regulation of respiratory system process (GO:0044065)2.58138699
154mitotic sister chromatid cohesion (GO:0007064)2.58124381
155poly(A)+ mRNA export from nucleus (GO:0016973)2.57110121
156mast cell activation (GO:0045576)2.56766045
157ribonucleoprotein complex biogenesis (GO:0022613)2.56483991
158macrophage activation involved in immune response (GO:0002281)2.55514697
159negative regulation of interleukin-12 production (GO:0032695)2.55046489
160negative regulation of execution phase of apoptosis (GO:1900118)2.55030611
161histone H3-K4 trimethylation (GO:0080182)2.54955975
162B cell receptor signaling pathway (GO:0050853)2.54936390
163metanephric nephron tubule development (GO:0072234)2.53976134
164metanephric tubule development (GO:0072170)2.53976134
165regulation of myeloid leukocyte mediated immunity (GO:0002886)2.53607886
166negative regulation of histone modification (GO:0031057)2.52723881
167pinocytosis (GO:0006907)2.52523885
168megakaryocyte development (GO:0035855)2.50061464
169neutrophil activation involved in immune response (GO:0002283)2.49089459
170regulation of interferon-beta biosynthetic process (GO:0045357)2.48002856
171lipopolysaccharide-mediated signaling pathway (GO:0031663)2.47877949
172corticosteroid receptor signaling pathway (GO:0031958)2.47579818
173leukocyte aggregation (GO:0070486)2.44749777
174T cell selection (GO:0045058)2.44735227
175regulation of histone H3-K4 methylation (GO:0051569)2.44654849
176immunoglobulin mediated immune response (GO:0016064)2.44162018
177positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.43801555
178apoptotic process involved in morphogenesis (GO:0060561)2.43144470
179negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.41795145
180regulation of B cell differentiation (GO:0045577)2.38678360
181response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.38202094
182response to host (GO:0075136)2.38202094
183response to host defenses (GO:0052200)2.38202094
184negative thymic T cell selection (GO:0045060)2.37723901
185glucocorticoid receptor signaling pathway (GO:0042921)2.35659165
186mitotic nuclear envelope disassembly (GO:0007077)2.34753866
187positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.33920893
188response to host immune response (GO:0052572)2.33426026
189response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.33426026
190NIK/NF-kappaB signaling (GO:0038061)2.33047387
191regulation of monocyte differentiation (GO:0045655)2.32337201
192regulation of mast cell activation involved in immune response (GO:0033006)2.31408875
193germinal center formation (GO:0002467)2.31280556
194membrane disassembly (GO:0030397)2.31273246
195nuclear envelope disassembly (GO:0051081)2.31273246
196positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.29451688
197activation of Rac GTPase activity (GO:0032863)2.29238144
198regulation of erythrocyte differentiation (GO:0045646)2.29186187
199negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.28308364

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.42292934
2EZH2_22144423_ChIP-Seq_EOC_Human5.07382826
3MYC_22102868_ChIP-Seq_BL_Human3.76495184
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.75486782
5IRF1_19129219_ChIP-ChIP_H3396_Human3.49262192
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.94859418
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.90550041
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.88684542
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.82453636
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.80085069
11KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.52735445
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.48063039
13TCF7_22412390_ChIP-Seq_EML_Mouse2.45487619
14TAF15_26573619_Chip-Seq_HEK293_Human2.45383110
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.41315982
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.41273088
17KDM2B_26808549_Chip-Seq_SUP-B15_Human2.37969393
18KDM2B_26808549_Chip-Seq_DND41_Human2.25530225
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.18917265
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.18031182
21IGF1R_20145208_ChIP-Seq_DFB_Human2.17196181
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16574840
23KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.13778472
24E2F7_22180533_ChIP-Seq_HELA_Human2.08559071
25WT1_19549856_ChIP-ChIP_CCG9911_Human2.02249336
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.99810852
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.97758084
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.95836608
29NFE2_27457419_Chip-Seq_LIVER_Mouse1.91268063
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89402812
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.87996484
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.86674754
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.84468805
34SCL_19346495_ChIP-Seq_HPC-7_Human1.83241837
35MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.81251518
36* RUNX1_22412390_ChIP-Seq_EML_Mouse1.80829339
37LXR_22292898_ChIP-Seq_THP-1_Human1.75186425
38DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.73765200
39MYC_18555785_ChIP-Seq_MESCs_Mouse1.71960305
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71688666
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.71448737
42* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71325447
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70077990
44MAF_26560356_Chip-Seq_TH1_Human1.67873962
45* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.67354615
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67299814
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.67099105
48EST1_17652178_ChIP-ChIP_JURKAT_Human1.65707130
49MYB_26560356_Chip-Seq_TH2_Human1.63242517
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.62162004
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.61966034
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61797098
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.61545462
54KDM2B_26808549_Chip-Seq_JURKAT_Human1.60990198
55* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.58611809
56* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.58244539
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.57979144
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57294584
59NCOR1_26117541_ChIP-Seq_K562_Human1.53673468
60STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.53140412
61RACK7_27058665_Chip-Seq_MCF-7_Human1.52689658
62STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52383440
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51866905
64RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.50823586
65HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50671369
66GBX2_23144817_ChIP-Seq_PC3_Human1.47645107
67GABP_17652178_ChIP-ChIP_JURKAT_Human1.46504644
68GATA1_22025678_ChIP-Seq_K562_Human1.45720852
69* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.44147941
70KDM2B_26808549_Chip-Seq_K562_Human1.44056423
71HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41138310
72MYC_18940864_ChIP-ChIP_HL60_Human1.40603384
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.40412517
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.40412517
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.40412517
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40378162
77EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.40278724
78STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.38824516
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.38285871
80TFEB_21752829_ChIP-Seq_HELA_Human1.35938199
81IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35916032
82FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.35905812
83P300_18555785_Chip-Seq_ESCs_Mouse1.34406346
84CIITA_25753668_ChIP-Seq_RAJI_Human1.33983841
85P53_22387025_ChIP-Seq_ESCs_Mouse1.33714309
86E2F4_17652178_ChIP-ChIP_JURKAT_Human1.33348517
87EZH2_27304074_Chip-Seq_ESCs_Mouse1.32433993
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31505081
89BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31085625
90CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30933842
91SUZ12_18555785_Chip-Seq_ESCs_Mouse1.30540555
92SPI1_23127762_ChIP-Seq_K562_Human1.30510132
93VDR_23849224_ChIP-Seq_CD4+_Human1.30257147
94RUNX1_27457419_Chip-Seq_LIVER_Mouse1.29715323
95NMYC_18555785_Chip-Seq_ESCs_Mouse1.29493505
96TTF2_22483619_ChIP-Seq_HELA_Human1.28896704
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28379833
98PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27916144
99BP1_19119308_ChIP-ChIP_Hs578T_Human1.27665174
100MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27558150
101* SPI1_23547873_ChIP-Seq_NB4_Human1.27542897
102ELK1_22589737_ChIP-Seq_MCF10A_Human1.27280768
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.26946335
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25191284
105GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24199040
106UTX_26944678_Chip-Seq_JUKART_Human1.23906610
107IRF8_22096565_ChIP-ChIP_GC-B_Human1.23822313
108CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23567521
109* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23350622
110THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23296922
111CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22227629
112P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21692323
113IRF8_27001747_Chip-Seq_BMDM_Mouse1.21600801
114KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21355806
115TP63_19390658_ChIP-ChIP_HaCaT_Human1.21129748
116EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20446522
117* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20362485
118TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19002105
119KDM5A_27292631_Chip-Seq_BREAST_Human1.18685269
120IRF8_21731497_ChIP-ChIP_J774_Mouse1.17729809
121MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17544933
122POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16754393
123KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.16012316
124MYB_26560356_Chip-Seq_TH1_Human1.15934554
125RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14652919
126PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13914582
127CMYC_18555785_Chip-Seq_ESCs_Mouse1.13530446
128STAT3_18555785_Chip-Seq_ESCs_Mouse1.12696122
129POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12598468
130E2F1_18555785_Chip-Seq_ESCs_Mouse1.12582726
131GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11704907
132GATA1_19941827_ChIP-Seq_MEL_Mouse1.10307616
133OCT4_18555785_Chip-Seq_ESCs_Mouse1.09970978
134* VDR_24763502_ChIP-Seq_THP-1_Human1.09734165
135* P68_20966046_ChIP-Seq_HELA_Human1.09354789
136CBX2_27304074_Chip-Seq_ESCs_Mouse1.08542028
137* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08095679
138PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07403879
139SOX2_18555785_Chip-Seq_ESCs_Mouse1.07279499
140GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06971779
141FOXP3_21729870_ChIP-Seq_TREG_Human1.06693007
142CRX_20693478_ChIP-Seq_RETINA_Mouse1.06399693
143ZFX_18555785_Chip-Seq_ESCs_Mouse1.05839395
144ATF3_27146783_Chip-Seq_COLON_Human1.05629504
145SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05447709
146RNF2_27304074_Chip-Seq_NSC_Mouse1.05193054
147RUNX_20019798_ChIP-Seq_JUKART_Human1.05013681
148PU_27001747_Chip-Seq_BMDM_Mouse1.04606915
149ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04006287
150* E2F1_21310950_ChIP-Seq_MCF-7_Human1.03715636
151PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02754971
152MYC_19079543_ChIP-ChIP_MESCs_Mouse1.02513493
153CREB1_26743006_Chip-Seq_LNCaP_Human1.02463429
154ESRRB_18555785_Chip-Seq_ESCs_Mouse1.02180920
155EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00779688
156VDR_21846776_ChIP-Seq_THP-1_Human1.00261981
157XRN2_22483619_ChIP-Seq_HELA_Human0.99085998
158GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98717830
159KLF4_18555785_Chip-Seq_ESCs_Mouse0.98589430
160EED_16625203_ChIP-ChIP_MESCs_Mouse0.97328718
161PU1_27457419_Chip-Seq_LIVER_Mouse0.97307008
162MAF_26560356_Chip-Seq_TH2_Human0.95846053
163* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95749565
164* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95196789
165* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94862368
166SA1_27219007_Chip-Seq_ERYTHROID_Human0.94635457
167SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94593015
168KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94352766
169ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94318199
170MYC_19030024_ChIP-ChIP_MESCs_Mouse0.93912864
171CTCF_18555785_Chip-Seq_ESCs_Mouse0.93847094
172SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.93715294
173SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.93132622
174SMAD1_18555785_Chip-Seq_ESCs_Mouse0.93069465

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.87746721
2MP0003880_abnormal_central_pattern5.46027322
3MP0003136_yellow_coat_color5.15803271
4MP0005409_darkened_coat_color4.36568060
5MP0004381_abnormal_hair_follicle4.20755441
6MP0001188_hyperpigmentation4.20232359
7MP0006292_abnormal_olfactory_placode3.95798362
8MP0005174_abnormal_tail_pigmentation3.42420942
9MP0002009_preneoplasia2.89199980
10MP0005451_abnormal_body_composition2.79331030
11MP0008057_abnormal_DNA_replication2.77077041
12MP0005076_abnormal_cell_differentiation2.71297803
13MP0009278_abnormal_bone_marrow2.62227504
14MP0000015_abnormal_ear_pigmentation2.56029396
15MP0005058_abnormal_lysosome_morphology2.42746818
16MP0004808_abnormal_hematopoietic_stem2.41415738
17MP0003705_abnormal_hypodermis_morpholog2.23245441
18MP0004185_abnormal_adipocyte_glucose2.10113951
19MP0003111_abnormal_nucleus_morphology2.09697298
20MP0003172_abnormal_lysosome_physiology1.95846009
21MP0003938_abnormal_ear_development1.92040519
22MP0005075_abnormal_melanosome_morpholog1.88341131
23MP0003724_increased_susceptibility_to1.87873615
24MP0006276_abnormal_autonomic_nervous1.81836748
25MP0003077_abnormal_cell_cycle1.79714521
26MP0002095_abnormal_skin_pigmentation1.77337847
27MP0003763_abnormal_thymus_physiology1.76364058
28MP0002877_abnormal_melanocyte_morpholog1.74494542
29MP0000372_irregular_coat_pigmentation1.74105926
30MP0004233_abnormal_muscle_weight1.73673500
31MP0005397_hematopoietic_system_phenotyp1.67617992
32MP0001545_abnormal_hematopoietic_system1.67617992
33MP0003693_abnormal_embryo_hatching1.67295471
34MP0010307_abnormal_tumor_latency1.64446132
35MP0003300_gastrointestinal_ulcer1.62517313
36MP0005671_abnormal_response_to1.60971526
37MP0004947_skin_inflammation1.58562751
38MP0002638_abnormal_pupillary_reflex1.58255945
39MP0003656_abnormal_erythrocyte_physiolo1.54989927
40MP0002177_abnormal_outer_ear1.53473000
41MP0003453_abnormal_keratinocyte_physiol1.51439893
42MP0001986_abnormal_taste_sensitivity1.51023827
43MP0000350_abnormal_cell_proliferation1.47264544
44MP0000490_abnormal_crypts_of1.46887215
45MP0008260_abnormal_autophagy1.46824321
46MP0003868_abnormal_feces_composition1.46676882
47MP0001730_embryonic_growth_arrest1.46304379
48MP0008007_abnormal_cellular_replicative1.42004600
49MP0009840_abnormal_foam_cell1.38714517
50MP0003866_abnormal_defecation1.35795063
51MP0000566_synostosis1.34437807
52MP0002751_abnormal_autonomic_nervous1.33125976
53MP0000681_abnormal_thyroid_gland1.31024516
54MP0000465_gastrointestinal_hemorrhage1.29870145
55MP0002166_altered_tumor_susceptibility1.29815227
56MP0005464_abnormal_platelet_physiology1.29320038
57MP0001800_abnormal_humoral_immune1.26970268
58MP0005000_abnormal_immune_tolerance1.26875212
59MP0003091_abnormal_cell_migration1.24283745
60MP0002420_abnormal_adaptive_immunity1.23845627
61MP0009785_altered_susceptibility_to1.22193683
62MP0003303_peritoneal_inflammation1.21941945
63MP0009333_abnormal_splenocyte_physiolog1.21656370
64MP0001819_abnormal_immune_cell1.21442845
65MP0002723_abnormal_immune_serum1.19721197
66MP0000049_abnormal_middle_ear1.18630085
67MP0005025_abnormal_response_to1.16339654
68MP0003566_abnormal_cell_adhesion1.15978998
69MP0002998_abnormal_bone_remodeling1.14361484
70MP0000313_abnormal_cell_death1.13294657
71MP0002249_abnormal_larynx_morphology1.11025378
72MP0002452_abnormal_antigen_presenting1.10478126
73MP0005621_abnormal_cell_physiology1.10366656
74MP0000678_abnormal_parathyroid_gland1.09430092
75MP0004142_abnormal_muscle_tone1.06877932
76MP0000858_altered_metastatic_potential1.06671840
77MP0002006_tumorigenesis1.06299378
78MP0005387_immune_system_phenotype1.06051814
79MP0001790_abnormal_immune_system1.06051814
80MP0000613_abnormal_salivary_gland1.04775719
81MP0002398_abnormal_bone_marrow1.04667844
82MP0002148_abnormal_hypersensitivity_rea1.03257049
83MP0003984_embryonic_growth_retardation1.03165819
84MP0005380_embryogenesis_phenotype1.02582853
85MP0001672_abnormal_embryogenesis/_devel1.02582853
86MP0001968_abnormal_touch/_nociception1.01958615
87MP0000733_abnormal_muscle_development1.01519668
88MP0008058_abnormal_DNA_repair1.00577942
89MP0000631_abnormal_neuroendocrine_gland0.99006371
90MP0003191_abnormal_cellular_cholesterol0.98540725
91MP0004957_abnormal_blastocyst_morpholog0.98241843
92MP0002277_abnormal_respiratory_mucosa0.97994801
93MP0003436_decreased_susceptibility_to0.97683097
94MP0000716_abnormal_immune_system0.97465884
95MP0002019_abnormal_tumor_incidence0.97144928
96MP0002088_abnormal_embryonic_growth/wei0.96785223
97MP0002080_prenatal_lethality0.96535774
98MP0002086_abnormal_extraembryonic_tissu0.95698123
99MP0002102_abnormal_ear_morphology0.95382518
100MP0000685_abnormal_immune_system0.94880361
101MP0001849_ear_inflammation0.93676220
102MP0004264_abnormal_extraembryonic_tissu0.93033576
103MP0003943_abnormal_hepatobiliary_system0.92756362
104MP0010352_gastrointestinal_tract_polyps0.92646255
105MP0000703_abnormal_thymus_morphology0.92323209
106MP0008569_lethality_at_weaning0.92267691
107MP0002796_impaired_skin_barrier0.92133722
108MP0001533_abnormal_skeleton_physiology0.91363059
109MP0005666_abnormal_adipose_tissue0.91179072
110MP0002419_abnormal_innate_immunity0.88636319
111MP0002396_abnormal_hematopoietic_system0.88175036
112MP0010234_abnormal_vibrissa_follicle0.86819625
113MP0002089_abnormal_postnatal_growth/wei0.85044511
114MP0002938_white_spotting0.84139299
115MP0005375_adipose_tissue_phenotype0.84037706
116MP0005310_abnormal_salivary_gland0.82557896
117MP0005384_cellular_phenotype0.81825094
118MP0001697_abnormal_embryo_size0.81823808
119MP0001915_intracranial_hemorrhage0.81037531
120MP0009931_abnormal_skin_appearance0.80436430
121MP0001663_abnormal_digestive_system0.80301029
122MP0002722_abnormal_immune_system0.78912948
123MP0001835_abnormal_antigen_presentation0.78470911
124MP0009672_abnormal_birth_weight0.78287712
125MP0002429_abnormal_blood_cell0.78039879
126MP0000689_abnormal_spleen_morphology0.76401738
127MP0008995_early_reproductive_senescence0.75010701
128MP0010630_abnormal_cardiac_muscle0.74882951
129MP0000003_abnormal_adipose_tissue0.74789887
130MP0001905_abnormal_dopamine_level0.73050174
131MP0003315_abnormal_perineum_morphology0.72920549
132MP0000026_abnormal_inner_ear0.72596257
133MP0002067_abnormal_sensory_capabilities0.72467008
134MP0005394_taste/olfaction_phenotype0.71839656
135MP0005499_abnormal_olfactory_system0.71839656
136MP0008789_abnormal_olfactory_epithelium0.70933890
137MP0004742_abnormal_vestibular_system0.68020236
138MP0002557_abnormal_social/conspecific_i0.67544850
139MP0001661_extended_life_span0.64747432
140MP0003879_abnormal_hair_cell0.64275062
141MP0003718_maternal_effect0.63334933
142MP0003011_delayed_dark_adaptation0.62916675
143MP0005381_digestive/alimentary_phenotyp0.61992948
144MP0001765_abnormal_ion_homeostasis0.61600552
145MP0005084_abnormal_gallbladder_morpholo0.61324610
146MP0010094_abnormal_chromosome_stability0.59252063
147MP0005379_endocrine/exocrine_gland_phen0.59135248
148MP0009745_abnormal_behavioral_response0.58901068
149MP0001340_abnormal_eyelid_morphology0.58373194
150MP0001919_abnormal_reproductive_system0.58108607
151MP0003828_pulmonary_edema0.57012459
152MP0010155_abnormal_intestine_physiology0.55728282
153MP0003646_muscle_fatigue0.55662388
154MP0002272_abnormal_nervous_system0.52843089
155MP0003786_premature_aging0.52749770
156MP0001963_abnormal_hearing_physiology0.52217627
157MP0002876_abnormal_thyroid_physiology0.50840419
158MP0001970_abnormal_pain_threshold0.49984766
159MP0002405_respiratory_system_inflammati0.49920504
160MP0001853_heart_inflammation0.48962824

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.45410913
2Reduced antithrombin III activity (HP:0001976)4.39625292
3Abnormality of cells of the erythroid lineage (HP:0012130)4.32158460
4Abnormal number of erythroid precursors (HP:0012131)4.27017925
5Abnormal hemoglobin (HP:0011902)4.26036886
6Nonprogressive disorder (HP:0003680)4.25215986
7Macrocytic anemia (HP:0001972)4.24456312
8Pseudobulbar signs (HP:0002200)4.19525752
9Hypothermia (HP:0002045)4.16964612
10Type I transferrin isoform profile (HP:0003642)3.97756405
11Decreased circulating renin level (HP:0003351)3.87141497
12Amelogenesis imperfecta (HP:0000705)3.74221610
13Abnormality of renin-angiotensin system (HP:0000847)3.58105110
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.54514727
15Pallor (HP:0000980)3.49721790
16Hyperactive renin-angiotensin system (HP:0000841)3.46923203
17Thyroid-stimulating hormone excess (HP:0002925)3.43036257
18Absent rod-and cone-mediated responses on ERG (HP:0007688)3.36237214
19Metabolic alkalosis (HP:0200114)3.31784252
20Abnormality of dental color (HP:0011073)3.31335599
21Abnormality of the axillary hair (HP:0100134)3.27859596
22Abnormality of secondary sexual hair (HP:0009888)3.27859596
23Hyponatremia (HP:0002902)3.12437209
24Eczematoid dermatitis (HP:0000976)3.10154564
25Recurrent bacterial skin infections (HP:0005406)3.02588782
26Abnormality of macrophages (HP:0004311)3.02367227
27Stomatitis (HP:0010280)3.01689260
28Recurrent abscess formation (HP:0002722)3.00556967
29Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.99804398
30Peripheral hypomyelination (HP:0007182)2.92667388
31Optic disc pallor (HP:0000543)2.90863974
32Chronic obstructive pulmonary disease (HP:0006510)2.85925422
33Obstructive lung disease (HP:0006536)2.85925422
34Abnormality of the fingertips (HP:0001211)2.85662169
35Aplasia/Hypoplasia of the sacrum (HP:0008517)2.82476533
36Abnormality of chloride homeostasis (HP:0011422)2.76951073
37Intellectual disability, progressive (HP:0006887)2.76923610
38Meningitis (HP:0001287)2.76506143
39Recurrent viral infections (HP:0004429)2.71183667
40Cellulitis (HP:0100658)2.67459056
41Thoracic kyphosis (HP:0002942)2.64064099
42Progressive inability to walk (HP:0002505)2.63693044
43Elevated erythrocyte sedimentation rate (HP:0003565)2.62217817
44Cone-rod dystrophy (HP:0000548)2.61482427
45Attenuation of retinal blood vessels (HP:0007843)2.59926570
46Abnormality of the thoracic spine (HP:0100711)2.54256584
47Obstructive sleep apnea (HP:0002870)2.53386310
48Progressive external ophthalmoplegia (HP:0000590)2.51216727
49Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.50509147
50Hyperacusis (HP:0010780)2.50448332
51Abnormal protein glycosylation (HP:0012346)2.50431637
52Abnormal glycosylation (HP:0012345)2.50431637
53Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.50431637
54Abnormal protein N-linked glycosylation (HP:0012347)2.50431637
55Concave nail (HP:0001598)2.46605188
56Chronic mucocutaneous candidiasis (HP:0002728)2.45664144
57Recurrent cutaneous fungal infections (HP:0011370)2.45664144
58Abnormality of sodium homeostasis (HP:0010931)2.44900840
59Colitis (HP:0002583)2.43931478
60Dysmetric saccades (HP:0000641)2.42004736
61Drooling (HP:0002307)2.38218399
62Excessive salivation (HP:0003781)2.38218399
63Increased hepatocellular lipid droplets (HP:0006565)2.37936466
64Ulnar claw (HP:0001178)2.37034087
65Triphalangeal thumb (HP:0001199)2.36581006
66Abnormal sex determination (HP:0012244)2.35550207
67Sex reversal (HP:0012245)2.35550207
68Spinal cord lesions (HP:0100561)2.33491721
69Syringomyelia (HP:0003396)2.33491721
70Broad distal phalanx of finger (HP:0009836)2.33040003
71Agammaglobulinemia (HP:0004432)2.30410455
72Severe visual impairment (HP:0001141)2.26006398
73Long eyelashes (HP:0000527)2.25142077
74Recurrent fungal infections (HP:0002841)2.24804252
75Flat occiput (HP:0005469)2.24280675
76Increased cerebral lipofuscin (HP:0011813)2.24204191
77Dry hair (HP:0011359)2.23234612
78Anhidrosis (HP:0000970)2.23163848
79Testicular atrophy (HP:0000029)2.23027593
80Viral hepatitis (HP:0006562)2.22429948
81Flat acetabular roof (HP:0003180)2.20012295
82Renal Fanconi syndrome (HP:0001994)2.18679570
83Fatigue (HP:0012378)2.18018519
84Renal cell carcinoma (HP:0005584)2.16845302
85Slow saccadic eye movements (HP:0000514)2.15698875
86Abnormality of liposaccharide metabolism (HP:0010968)2.15152524
87Abnormality of glycosphingolipid metabolism (HP:0004343)2.15152524
88Abnormality of glycolipid metabolism (HP:0010969)2.15152524
89Vacuolated lymphocytes (HP:0001922)2.14997757
90Microvesicular hepatic steatosis (HP:0001414)2.14935433
91Glomerulonephritis (HP:0000099)2.13878948
92Broad face (HP:0000283)2.11431877
93Persistence of primary teeth (HP:0006335)2.09552994
94Abnormal rod and cone electroretinograms (HP:0008323)2.08276536
95Increased IgE level (HP:0003212)2.03779940
96Recurrent skin infections (HP:0001581)2.02790305
97Pustule (HP:0200039)2.02610721
98Disproportionate tall stature (HP:0001519)2.02483020
99Progressive muscle weakness (HP:0003323)2.02074109
100Capillary hemangiomas (HP:0005306)2.01354531
101Microcytic anemia (HP:0001935)2.00391215
102Exertional dyspnea (HP:0002875)2.00027769
103Abnormality of the distal phalanx of the thumb (HP:0009617)1.99785945
104Gastrointestinal inflammation (HP:0004386)1.98087752
105Increased neuronal autofluorescent lipopigment (HP:0002074)1.96645318
106Hepatocellular necrosis (HP:0001404)1.96575630
107Long palpebral fissure (HP:0000637)1.95862605
1083-Methylglutaconic aciduria (HP:0003535)1.95705340
109Vertebral arch anomaly (HP:0008438)1.95134476
110Homocystinuria (HP:0002156)1.93666920
111Abnormality of homocysteine metabolism (HP:0010919)1.93666920
112Centrally nucleated skeletal muscle fibers (HP:0003687)1.93074033
113Abnormality of magnesium homeostasis (HP:0004921)1.92892567
114Absent/shortened dynein arms (HP:0200106)1.92743449
115Dynein arm defect of respiratory motile cilia (HP:0012255)1.92743449
116Cortical visual impairment (HP:0100704)1.91848651
117Deep palmar crease (HP:0006191)1.89579094
118Abnormal drinking behavior (HP:0030082)1.89483717
119Polydipsia (HP:0001959)1.89483717
120Abnormality of the prostate (HP:0008775)1.89027169
121Hyperaldosteronism (HP:0000859)1.88204079
122Loss of speech (HP:0002371)1.87824716
123Dislocated radial head (HP:0003083)1.87236799
124Abnormality of the columella (HP:0009929)1.86880199
125Sensory axonal neuropathy (HP:0003390)1.86523633
126Acute lymphatic leukemia (HP:0006721)1.85328187
127Abnormal ciliary motility (HP:0012262)1.84511814
128J-shaped sella turcica (HP:0002680)1.84205664
129Parakeratosis (HP:0001036)1.84108898
130Abnormal delayed hypersensitivity skin test (HP:0002963)1.83904113
131Abnormality of the distal phalanges of the toes (HP:0010182)1.83853318
132Restlessness (HP:0000711)1.83464675
133Ocular albinism (HP:0001107)1.82819707
134Increased serum ferritin (HP:0003281)1.82341119
135Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.81485364
136Microglossia (HP:0000171)1.81378900
137Lipid accumulation in hepatocytes (HP:0006561)1.81317937
138Deformed sella turcica (HP:0002681)1.81308078
139Ankyloglossia (HP:0010296)1.81151839
140Migraine (HP:0002076)1.80442138
141Aplastic anemia (HP:0001915)1.80364511
142Abnormality of the aortic arch (HP:0012303)1.80199172
143Increased connective tissue (HP:0009025)1.80092538
144Pancytopenia (HP:0001876)1.79523397
145Gingivitis (HP:0000230)1.79459268
146Abnormal respiratory motile cilium morphology (HP:0005938)1.79421953
147Abnormal respiratory epithelium morphology (HP:0012253)1.79421953
148Broad-based gait (HP:0002136)1.78785071
149Osteomyelitis (HP:0002754)1.78284859
150Abnormality of oral frenula (HP:0000190)1.76050931
151Upper motor neuron abnormality (HP:0002127)1.75879184
152Panhypogammaglobulinemia (HP:0003139)1.75296498
153Inflammation of the large intestine (HP:0002037)1.74991219
154Focal motor seizures (HP:0011153)1.74716184
155Mediastinal lymphadenopathy (HP:0100721)1.74648923
156Alkalosis (HP:0001948)1.74621873
157Cerebral aneurysm (HP:0004944)1.74594327
158Polygenic inheritance (HP:0010982)1.73134236
159Bowel incontinence (HP:0002607)1.72413231
160IgG deficiency (HP:0004315)1.72021052
161Pointed chin (HP:0000307)1.71746957
162Abnormal large intestine physiology (HP:0012700)1.71517155
163Thrombocytosis (HP:0001894)1.70744364
164IgM deficiency (HP:0002850)1.70625448
165Prominent nose (HP:0000448)1.70244709
166Spontaneous hematomas (HP:0007420)1.69936528
167Abnormality of the lumbar spine (HP:0100712)1.69257068
168Distal lower limb amyotrophy (HP:0008944)1.69043961
169Subacute progressive viral hepatitis (HP:0006572)1.68334993
170Septate vagina (HP:0001153)1.67136489
171Abnormality of the radial head (HP:0003995)1.67017405
172Dysostosis multiplex (HP:0000943)1.66369922
173Ulnar bowing (HP:0003031)1.65501128
174Bicuspid aortic valve (HP:0001647)1.65261365
175Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.64826371
176Abnormality of the phalanges of the hallux (HP:0010057)1.64183179
177Hypertensive crisis (HP:0100735)1.63519449
178Chromosomal breakage induced by crosslinking agents (HP:0003221)1.61700502
179Acute myeloid leukemia (HP:0004808)1.59880942
180Asymmetry of the thorax (HP:0001555)1.59508080
181Metaphyseal cupping (HP:0003021)1.56510160
182Myositis (HP:0100614)1.56220832
183Myocardial infarction (HP:0001658)1.56100334
184Heterotopia (HP:0002282)1.55733083
185High anterior hairline (HP:0009890)1.53825298
186Deep philtrum (HP:0002002)1.52859657
187Cafe-au-lait spot (HP:0000957)1.52024264

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.11025374
2TNIK4.78922502
3CDK124.31435847
4PRKD24.26097001
5TLK14.13762625
6TRIB33.83908838
7STK383.70365353
8NLK3.39251248
9MKNK23.04745042
10EEF2K2.93755109
11SMG12.92932077
12TSSK62.91446592
13NME22.70184449
14CLK12.61302344
15MAP2K32.60624543
16ICK2.43422270
17MAP3K102.40182357
18IRAK42.14093230
19MAPK151.98349019
20EIF2AK31.97130890
21MUSK1.97118491
22SRPK11.93724651
23MAP3K131.93038538
24SIK11.90497276
25ERN11.85393438
26IRAK31.76267029
27FES1.75367977
28TXK1.70166993
29BLK1.64262109
30FGR1.63005455
31MKNK11.57371903
32HIPK21.57161677
33STK111.57022529
34GRK61.54009534
35TYK21.52263491
36MST41.43197040
37YES11.42213018
38CAMK1G1.42031496
39KSR21.41060272
40GRK71.40833422
41STK161.39157971
42IRAK11.38991537
43CAMK1D1.36239534
44TEC1.34314711
45IRAK21.32802409
46UHMK11.30354760
47BRD41.29821530
48TAOK11.29034034
49VRK11.28111057
50MTOR1.24267939
51TTN1.23584912
52TAOK21.23539205
53CDK191.21606512
54EIF2AK21.17193560
55MAPKAPK51.11556084
56EIF2AK11.09137568
57MAP4K11.08685506
58CSF1R1.00632649
59MAP3K30.94480155
60MARK20.92619140
61RPS6KB20.92274099
62CDK60.91301508
63MAP3K80.90023848
64MAP3K60.87944076
65MAP3K10.87557154
66PKN20.87216538
67TGFBR20.84398476
68MAPK110.84395742
69RAF10.83993081
70BTK0.82883548
71CSNK1G10.79602903
72CDC42BPA0.78227555
73RIPK40.76945909
74KIT0.76052604
75BMX0.73909496
76CDK90.73721435
77CHEK10.73291107
78PIM10.72244218
79MAP2K70.71952635
80CDC70.70647495
81CAMK2B0.69115559
82PDPK10.67750426
83RET0.67091312
84PTK60.66418897
85DYRK30.65070040
86MARK30.64993218
87MAPK120.64698325
88TAOK30.64315443
89FGFR40.64258958
90IKBKE0.63191547
91MAP2K20.62979123
92STK390.62700428
93CSK0.62337470
94LYN0.60544648
95ADRBK20.59628810
96CDK30.59005324
97LCK0.58344305
98MAP3K110.54985633
99WEE10.54661281
100PRKD10.54633303
101ZAP700.53815446
102MAP3K70.53507425
103MELK0.53173013
104FGFR30.52112380
105RPS6KA20.51815742
106CHEK20.50724377
107PDK10.50434225
108TYRO30.50292419
109DYRK1B0.49805655
110CAMK10.49325474
111CHUK0.48419708
112RPS6KA10.48331634
113TESK20.47652022
114PIM20.47344514
115SYK0.47080933
116MAPK130.46639287
117STK40.45812327
118JAK20.45346555
119RIPK10.45064683
120RPS6KA60.44981516
121CDK20.43248056
122ATR0.43110559
123CAMKK20.42132215
124ARAF0.42045178
125MAP3K20.41061094
126PDGFRB0.40894931
127LRRK20.40471183
128IKBKB0.39160051
129TNK20.39001907
130BUB10.38999936
131KDR0.38873830
132PRPF4B0.37954179
133STK100.37147176
134DYRK1A0.34817005
135HCK0.31599347
136CDK70.31140324
137MAP3K140.30752896
138GRK50.29557701
139ITK0.28924916
140MAPK40.27942266
141TBK10.27856147
142CAMK2A0.27678476
143RPS6KA50.27559041
144GRK10.26758667
145CSNK1G30.24852026
146CDK40.23360101
147MAP3K120.23085622
148SIK20.23038752
149DYRK20.20820153
150BMPR20.20752157
151BMPR1B0.19099891
152NME10.18182643
153CSNK2A20.17340276
154ABL10.17058723
155CSNK2A10.15632293
156RPS6KL10.15123009
157RPS6KC10.15123009
158MOS0.15092557
159PRKG20.14567200
160JAK30.13847766
161WNK10.13760815
162PRKAA20.13299910
163PAK10.11180886

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.35618920
2DNA replication_Homo sapiens_hsa030302.87700415
3Thyroid cancer_Homo sapiens_hsa052162.82641518
4Protein export_Homo sapiens_hsa030602.44007380
5Chronic myeloid leukemia_Homo sapiens_hsa052202.34947903
6Spliceosome_Homo sapiens_hsa030402.19056767
7Primary immunodeficiency_Homo sapiens_hsa053402.01014309
8Homologous recombination_Homo sapiens_hsa034401.93947398
9Non-small cell lung cancer_Homo sapiens_hsa052231.93239821
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.91920028
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.84585200
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.82516740
13Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.81615779
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.80431841
15Antigen processing and presentation_Homo sapiens_hsa046121.79652208
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.75767449
17Graft-versus-host disease_Homo sapiens_hsa053321.74198201
18Other glycan degradation_Homo sapiens_hsa005111.72085684
19Ether lipid metabolism_Homo sapiens_hsa005651.70830737
20Fanconi anemia pathway_Homo sapiens_hsa034601.69537498
21Measles_Homo sapiens_hsa051621.68357099
22Pancreatic cancer_Homo sapiens_hsa052121.67296532
23Sphingolipid metabolism_Homo sapiens_hsa006001.67142831
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.67042921
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.61560244
26Acute myeloid leukemia_Homo sapiens_hsa052211.51662116
27VEGF signaling pathway_Homo sapiens_hsa043701.50998302
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.49602020
29RNA polymerase_Homo sapiens_hsa030201.49347912
30Renal cell carcinoma_Homo sapiens_hsa052111.39060098
31Notch signaling pathway_Homo sapiens_hsa043301.37575576
32Sulfur relay system_Homo sapiens_hsa041221.34520998
33mTOR signaling pathway_Homo sapiens_hsa041501.32875073
34Bladder cancer_Homo sapiens_hsa052191.32688036
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.32557556
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.32190584
37Pyrimidine metabolism_Homo sapiens_hsa002401.31540994
38Viral carcinogenesis_Homo sapiens_hsa052031.31042464
39Phototransduction_Homo sapiens_hsa047441.26936054
40Basal transcription factors_Homo sapiens_hsa030221.26242714
41TNF signaling pathway_Homo sapiens_hsa046681.26166497
42Cell cycle_Homo sapiens_hsa041101.23924509
43ErbB signaling pathway_Homo sapiens_hsa040121.21488673
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.18410382
45Toxoplasmosis_Homo sapiens_hsa051451.17778303
46NF-kappa B signaling pathway_Homo sapiens_hsa040641.16685540
47Prolactin signaling pathway_Homo sapiens_hsa049171.16248322
48Nicotine addiction_Homo sapiens_hsa050331.16091178
49Central carbon metabolism in cancer_Homo sapiens_hsa052301.15971165
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13382840
51Apoptosis_Homo sapiens_hsa042101.13141562
52Glioma_Homo sapiens_hsa052141.12426884
53Nucleotide excision repair_Homo sapiens_hsa034201.11562112
54Hepatitis C_Homo sapiens_hsa051601.10527965
55mRNA surveillance pathway_Homo sapiens_hsa030151.06428982
56Hematopoietic cell lineage_Homo sapiens_hsa046401.06276063
57Tuberculosis_Homo sapiens_hsa051521.06166209
58Small cell lung cancer_Homo sapiens_hsa052221.06005206
59HTLV-I infection_Homo sapiens_hsa051661.03868664
60MicroRNAs in cancer_Homo sapiens_hsa052061.03855448
61Mismatch repair_Homo sapiens_hsa034301.03742826
62Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03470246
63Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.03437812
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03259989
65Longevity regulating pathway - mammal_Homo sapiens_hsa042111.02091573
66Wnt signaling pathway_Homo sapiens_hsa043100.99959463
67Long-term depression_Homo sapiens_hsa047300.99274946
68Basal cell carcinoma_Homo sapiens_hsa052170.98424172
69T cell receptor signaling pathway_Homo sapiens_hsa046600.98086479
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97537826
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95984382
72FoxO signaling pathway_Homo sapiens_hsa040680.93110070
73Oxidative phosphorylation_Homo sapiens_hsa001900.92068336
74B cell receptor signaling pathway_Homo sapiens_hsa046620.91838451
75Dorso-ventral axis formation_Homo sapiens_hsa043200.90261036
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88519757
77Shigellosis_Homo sapiens_hsa051310.87811596
78Prostate cancer_Homo sapiens_hsa052150.87575415
79Estrogen signaling pathway_Homo sapiens_hsa049150.87104369
80Herpes simplex infection_Homo sapiens_hsa051680.83553634
81Insulin signaling pathway_Homo sapiens_hsa049100.82945479
82Base excision repair_Homo sapiens_hsa034100.80354275
83One carbon pool by folate_Homo sapiens_hsa006700.79962084
84Allograft rejection_Homo sapiens_hsa053300.78378454
85Lysosome_Homo sapiens_hsa041420.78070628
86Purine metabolism_Homo sapiens_hsa002300.77053185
87Colorectal cancer_Homo sapiens_hsa052100.75253634
88Melanogenesis_Homo sapiens_hsa049160.75246759
89Non-homologous end-joining_Homo sapiens_hsa034500.74881056
90Insulin resistance_Homo sapiens_hsa049310.74371847
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73578810
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73194149
93Lysine degradation_Homo sapiens_hsa003100.72931250
94Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.71838696
95HIF-1 signaling pathway_Homo sapiens_hsa040660.71281709
96Inositol phosphate metabolism_Homo sapiens_hsa005620.70932773
97Legionellosis_Homo sapiens_hsa051340.70660735
98GnRH signaling pathway_Homo sapiens_hsa049120.70261967
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.68489810
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68298348
101Viral myocarditis_Homo sapiens_hsa054160.67732995
102Arachidonic acid metabolism_Homo sapiens_hsa005900.67730554
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.65855184
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65358138
105Leishmaniasis_Homo sapiens_hsa051400.65337170
106RNA transport_Homo sapiens_hsa030130.63808389
107MAPK signaling pathway_Homo sapiens_hsa040100.63534385
108Prion diseases_Homo sapiens_hsa050200.63347037
109Morphine addiction_Homo sapiens_hsa050320.63242670
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62964223
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62376203
112Amoebiasis_Homo sapiens_hsa051460.61913885
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.61778912
114Proteoglycans in cancer_Homo sapiens_hsa052050.59591336
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58505392
116Osteoclast differentiation_Homo sapiens_hsa043800.58294930
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57772527
118Salmonella infection_Homo sapiens_hsa051320.57468970
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.55527482
120Type II diabetes mellitus_Homo sapiens_hsa049300.54887783
121Autoimmune thyroid disease_Homo sapiens_hsa053200.53388746
122Pentose phosphate pathway_Homo sapiens_hsa000300.53162313
123Huntingtons disease_Homo sapiens_hsa050160.52645534
124Choline metabolism in cancer_Homo sapiens_hsa052310.52331812
125AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52289668
126Adherens junction_Homo sapiens_hsa045200.51371967
127AMPK signaling pathway_Homo sapiens_hsa041520.51155964
128Epstein-Barr virus infection_Homo sapiens_hsa051690.50684539
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.50432893
130Taste transduction_Homo sapiens_hsa047420.50158275
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49173900
132Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48863636
133Asthma_Homo sapiens_hsa053100.48369940
134Alzheimers disease_Homo sapiens_hsa050100.48138329
135Serotonergic synapse_Homo sapiens_hsa047260.47956768
136Malaria_Homo sapiens_hsa051440.47357530
137Pertussis_Homo sapiens_hsa051330.44940699
138Parkinsons disease_Homo sapiens_hsa050120.44617573
139Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43436325
140Folate biosynthesis_Homo sapiens_hsa007900.43309995
141Chemokine signaling pathway_Homo sapiens_hsa040620.41735942
142Systemic lupus erythematosus_Homo sapiens_hsa053220.41621485
143RNA degradation_Homo sapiens_hsa030180.41416137
144Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39589222
145Hepatitis B_Homo sapiens_hsa051610.39367966
146Glutamatergic synapse_Homo sapiens_hsa047240.39320100
147Phospholipase D signaling pathway_Homo sapiens_hsa040720.39265928
148p53 signaling pathway_Homo sapiens_hsa041150.39085788
149Endometrial cancer_Homo sapiens_hsa052130.38556368
150Olfactory transduction_Homo sapiens_hsa047400.37187135
151Pancreatic secretion_Homo sapiens_hsa049720.35496309
152Pathways in cancer_Homo sapiens_hsa052000.34467492
153Calcium signaling pathway_Homo sapiens_hsa040200.32502349
154Platelet activation_Homo sapiens_hsa046110.32491187
155Influenza A_Homo sapiens_hsa051640.31601919
156Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30966801
157Axon guidance_Homo sapiens_hsa043600.30283981
158N-Glycan biosynthesis_Homo sapiens_hsa005100.29267564

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