BRPF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)7.22561622
2protoporphyrinogen IX biosynthetic process (GO:0006782)6.50333431
3porphyrin-containing compound biosynthetic process (GO:0006779)5.02126889
4heme biosynthetic process (GO:0006783)4.49726717
5tetrapyrrole biosynthetic process (GO:0033014)4.31635716
6heterochromatin organization (GO:0070828)4.10425442
7pre-miRNA processing (GO:0031054)4.10358902
8cell-cell junction maintenance (GO:0045217)4.08681436
9porphyrin-containing compound metabolic process (GO:0006778)3.94717537
10L-alpha-amino acid transmembrane transport (GO:1902475)3.83815181
11regulation of cholesterol homeostasis (GO:2000188)3.81225630
12hemoglobin metabolic process (GO:0020027)3.72922976
13erythrocyte maturation (GO:0043249)3.69313318
14regulation of NFAT protein import into nucleus (GO:0051532)3.66642197
15mitotic sister chromatid segregation (GO:0000070)3.41547970
16chromatin assembly (GO:0031497)3.39681102
17receptor recycling (GO:0001881)3.38618818
18regulation of early endosome to late endosome transport (GO:2000641)3.38109046
19positive regulation of histone deacetylation (GO:0031065)3.37432865
20very-low-density lipoprotein particle assembly (GO:0034379)3.35719070
21heme metabolic process (GO:0042168)3.35629566
22plasma lipoprotein particle assembly (GO:0034377)3.32643759
23sister chromatid segregation (GO:0000819)3.29508017
24DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.28934684
25cell junction maintenance (GO:0034331)3.28048886
26regulation of hippo signaling (GO:0035330)3.22920376
27adherens junction assembly (GO:0034333)3.20204479
28protein-lipid complex assembly (GO:0065005)3.14443699
29nuclear pore complex assembly (GO:0051292)3.14378885
30mRNA stabilization (GO:0048255)3.14163436
31RNA stabilization (GO:0043489)3.14163436
32insulin-like growth factor receptor signaling pathway (GO:0048009)3.12115485
33cytoskeletal anchoring at plasma membrane (GO:0007016)3.10814646
34trophectodermal cell differentiation (GO:0001829)3.06382173
35epithelial cell-cell adhesion (GO:0090136)3.05918568
36mitotic chromosome condensation (GO:0007076)3.03710332
37histone H4-K12 acetylation (GO:0043983)3.03559935
38focal adhesion assembly (GO:0048041)3.02370069
39cell-substrate adherens junction assembly (GO:0007045)3.02370069
40maternal placenta development (GO:0001893)3.02120569
41planar cell polarity pathway involved in neural tube closure (GO:0090179)3.01997243
42negative regulation of histone methylation (GO:0031061)2.99681987
43low-density lipoprotein particle clearance (GO:0034383)2.99605785
44nuclear pore organization (GO:0006999)2.99389476
45intracellular estrogen receptor signaling pathway (GO:0030520)2.98013648
46maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.97657094
47response to arsenic-containing substance (GO:0046685)2.97286664
48regulation of translational fidelity (GO:0006450)2.97005866
49intestinal cholesterol absorption (GO:0030299)2.96178583
50positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.95272687
51positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.95272687
52positive regulation of mitotic sister chromatid separation (GO:1901970)2.95272687
53sulfur amino acid catabolic process (GO:0000098)2.94557152
54atrioventricular valve morphogenesis (GO:0003181)2.93207411
55cysteine metabolic process (GO:0006534)2.92053020
56protein retention in ER lumen (GO:0006621)2.84815183
57protein localization to endosome (GO:0036010)2.84359828
58lysine catabolic process (GO:0006554)2.82256859
59lysine metabolic process (GO:0006553)2.82256859
60DNA damage response, signal transduction resulting in transcription (GO:0042772)2.80969294
61alpha-linolenic acid metabolic process (GO:0036109)2.80839797
62protein localization to kinetochore (GO:0034501)2.78459234
63response to methylmercury (GO:0051597)2.78456253
64regulation of RNA export from nucleus (GO:0046831)2.78097746
65regulation of histone H3-K27 methylation (GO:0061085)2.77512540
66cytoplasmic mRNA processing body assembly (GO:0033962)2.77398117
67regulation of sister chromatid cohesion (GO:0007063)2.77384795
68embryonic retina morphogenesis in camera-type eye (GO:0060059)2.77266184
69regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.77125555
70erythrocyte development (GO:0048821)2.77093795
71mitotic sister chromatid cohesion (GO:0007064)2.74675179
72intestinal absorption (GO:0050892)2.72459207
73protein localization to chromosome, centromeric region (GO:0071459)2.71624734
74regulation of response to osmotic stress (GO:0047484)2.68519453
75paraxial mesoderm development (GO:0048339)2.66997988
76triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.66714957
77regulation of fatty acid beta-oxidation (GO:0031998)2.66389382
78skin morphogenesis (GO:0043589)2.66322301
79regulation of histone H3-K9 methylation (GO:0051570)2.66301767
80positive regulation of p38MAPK cascade (GO:1900745)2.64430735
81negative regulation of fatty acid transport (GO:2000192)2.64350855
82regulation of gene silencing by RNA (GO:0060966)2.64332814
83regulation of posttranscriptional gene silencing (GO:0060147)2.64332814
84regulation of gene silencing by miRNA (GO:0060964)2.64332814
85dosage compensation (GO:0007549)2.64113971
86activation of Rac GTPase activity (GO:0032863)2.64079660
87mitotic G1 DNA damage checkpoint (GO:0031571)2.62631963
88NLS-bearing protein import into nucleus (GO:0006607)2.61310658
89basement membrane organization (GO:0071711)2.59444746
90anterior/posterior axis specification, embryo (GO:0008595)2.58887379
91regulation of ARF GTPase activity (GO:0032312)2.58049412
92embryonic process involved in female pregnancy (GO:0060136)2.57365871
93regulation of ARF protein signal transduction (GO:0032012)2.57215550
94histone H3-K36 demethylation (GO:0070544)2.55889438
95regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.55792797
96negative regulation of fatty acid biosynthetic process (GO:0045717)2.55492077
97urea cycle (GO:0000050)2.53370350
98urea metabolic process (GO:0019627)2.53370350
99endocardial cushion development (GO:0003197)2.51374386
100positive regulation of chromosome segregation (GO:0051984)2.51118828
101stress fiber assembly (GO:0043149)2.50410873
102positive regulation of fatty acid beta-oxidation (GO:0032000)2.49810179
103regulation of integrin activation (GO:0033623)2.49451002
104gene silencing by RNA (GO:0031047)2.48435704
105negative regulation of cell size (GO:0045792)2.48355230
106gene silencing (GO:0016458)2.47582523
107tetrapyrrole metabolic process (GO:0033013)2.47399569
108peptidyl-lysine dimethylation (GO:0018027)2.47129555
109negative regulation of cholesterol transport (GO:0032375)2.46725105
110negative regulation of sterol transport (GO:0032372)2.46725105
111regulation of cholesterol storage (GO:0010885)2.46289657
112regulation of nucleobase-containing compound transport (GO:0032239)2.46060787
113DNA packaging (GO:0006323)2.44651191
114erythrocyte differentiation (GO:0030218)2.44204833
115DNA replication-dependent nucleosome assembly (GO:0006335)2.44150692
116DNA replication-dependent nucleosome organization (GO:0034723)2.44150692
117sexual reproduction (GO:0019953)2.44125209
118histone H4-K5 acetylation (GO:0043981)2.43506009
119histone H4-K8 acetylation (GO:0043982)2.43506009
120notochord development (GO:0030903)2.42801767
121histone H3-K9 demethylation (GO:0033169)2.42340333
122negative regulation of fibrinolysis (GO:0051918)2.41251540
123negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.41222265
124mitotic nuclear envelope disassembly (GO:0007077)2.40639246
125semaphorin-plexin signaling pathway (GO:0071526)2.40435271
126positive regulation of triglyceride metabolic process (GO:0090208)2.40225678
127chromosome condensation (GO:0030261)2.39974686
128establishment of apical/basal cell polarity (GO:0035089)2.38286295
1293-UTR-mediated mRNA stabilization (GO:0070935)2.37207995
130cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.35950863
131chromatin silencing (GO:0006342)2.35593907
132cell-substrate junction assembly (GO:0007044)2.35076583
133positive regulation of synapse maturation (GO:0090129)2.33014428
134regulation of stem cell maintenance (GO:2000036)2.32999155
135epoxygenase P450 pathway (GO:0019373)2.32991197
136Golgi transport vesicle coating (GO:0048200)2.32647946
137COPI coating of Golgi vesicle (GO:0048205)2.32647946
138intestinal epithelial cell development (GO:0060576)2.32413339
139nucleosome disassembly (GO:0006337)2.32098741
140protein-DNA complex disassembly (GO:0032986)2.32098741
141glucocorticoid receptor signaling pathway (GO:0042921)2.31219874
142synaptic vesicle docking involved in exocytosis (GO:0016081)2.30239622
143retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.30106635
144desmosome organization (GO:0002934)2.29013349
145cellular response to epidermal growth factor stimulus (GO:0071364)2.27807053
146regulation of bile acid biosynthetic process (GO:0070857)2.27799067
147peptidyl-threonine phosphorylation (GO:0018107)2.27570295
148camera-type eye morphogenesis (GO:0048593)2.27363683
149regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.27255012
150positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.26948319
151regulation of glucose import in response to insulin stimulus (GO:2001273)2.26276340
152RNA localization (GO:0006403)2.26019445
153positive regulation of gene expression, epigenetic (GO:0045815)2.25636751
154negative regulation of glycogen biosynthetic process (GO:0045719)2.24319329
155embryonic foregut morphogenesis (GO:0048617)2.24258413
156hippo signaling (GO:0035329)2.23989461
157macroautophagy (GO:0016236)2.23316500
158response to laminar fluid shear stress (GO:0034616)2.22805460
159regulation of mammary gland epithelial cell proliferation (GO:0033599)2.21903977
160regulation of extracellular matrix disassembly (GO:0010715)2.21050026
161modulation by virus of host morphology or physiology (GO:0019048)2.19167995
162activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.18746813
163embryonic eye morphogenesis (GO:0048048)2.18592107
164apoptotic process involved in morphogenesis (GO:0060561)2.18586687
165response to epidermal growth factor (GO:0070849)2.18177634
166negative regulation of erythrocyte differentiation (GO:0045647)2.17841457
167peptidyl-threonine modification (GO:0018210)2.17163096
168positive regulation of Cdc42 GTPase activity (GO:0043089)2.15634395
169histone lysine demethylation (GO:0070076)2.15197749
170COPII vesicle coating (GO:0048208)2.14896896
171branching involved in mammary gland duct morphogenesis (GO:0060444)2.14649566
172trophoblast giant cell differentiation (GO:0060707)2.13245303
173epithelial cell fate commitment (GO:0072148)2.12974494
174eye morphogenesis (GO:0048592)2.12399764
175embryonic camera-type eye morphogenesis (GO:0048596)2.12317980
176histone demethylation (GO:0016577)2.07871162
177histone H3-K4 trimethylation (GO:0080182)2.07192592
178positive regulation of macroautophagy (GO:0016239)2.07190094
179sodium ion export (GO:0071436)2.07082859

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.73531099
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.58239368
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.10261831
4MYC_22102868_ChIP-Seq_BL_Human2.86744675
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.73692515
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.56607549
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.56147837
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.29103686
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.26303540
10TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.24421453
11GATA1_19941826_ChIP-Seq_K562_Human2.21056656
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.19297373
13* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.15990050
14SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.13768526
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.10470230
16WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.07202171
17TCF7_22412390_ChIP-Seq_EML_Mouse2.06227509
18ZNF263_19887448_ChIP-Seq_K562_Human2.04052410
19KDM2B_26808549_Chip-Seq_DND41_Human1.99123277
20* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.98101427
21KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.89465303
22KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.87347969
23VDR_21846776_ChIP-Seq_THP-1_Human1.87088854
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.80765038
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.78041765
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75844683
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75722461
28SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.74024552
29GATA1_19941827_ChIP-Seq_MEL_Mouse1.70177399
30* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.69742088
31TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.69216004
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69183209
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.66641038
34NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.65743439
35KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.65354857
36KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.65354857
37KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.65354857
38NCOR1_26117541_ChIP-Seq_K562_Human1.65010564
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.63505081
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.63434386
41* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.61936044
42LXR_22292898_ChIP-Seq_THP-1_Human1.61181976
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.60811896
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.59924175
45GATA1_22025678_ChIP-Seq_K562_Human1.57792033
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.56305192
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53235204
48ESR1_15608294_ChIP-ChIP_MCF-7_Human1.50576978
49KDM2B_26808549_Chip-Seq_K562_Human1.50006400
50RACK7_27058665_Chip-Seq_MCF-7_Human1.49320920
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.49259679
52ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.47981835
53UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.44562021
54NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.43329088
55* FOXA2_19822575_ChIP-Seq_HepG2_Human1.43324918
56KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.41586183
57SMC4_20622854_ChIP-Seq_HELA_Human1.39853199
58CLOCK_20551151_ChIP-Seq_293T_Human1.39546975
59ESR1_21235772_ChIP-Seq_MCF-7_Human1.38635371
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37985799
61ZFP281_27345836_Chip-Seq_ESCs_Mouse1.37519476
62SCL_19346495_ChIP-Seq_HPC-7_Human1.37033172
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36633098
64HIF1A_21447827_ChIP-Seq_MCF-7_Human1.36217212
65ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36135042
66FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.35935075
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.35462843
68TP63_17297297_ChIP-ChIP_HaCaT_Human1.34556950
69GATA6_25053715_ChIP-Seq_YYC3_Human1.33686068
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33120952
71ATF3_27146783_Chip-Seq_COLON_Human1.32207853
72P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31588211
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30718793
74SOX9_24532713_ChIP-Seq_HFSC_Mouse1.29853247
75* CREB1_26743006_Chip-Seq_LNCaP_Human1.29422207
76GATA2_19941826_ChIP-Seq_K562_Human1.28928316
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28318510
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28309411
79AR_21909140_ChIP-Seq_LNCAP_Human1.23986839
80UTX_26944678_Chip-Seq_JUKART_Human1.23101055
81SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.21893566
82MAF_26560356_Chip-Seq_TH1_Human1.21470963
83* KDM2B_26808549_Chip-Seq_JURKAT_Human1.20788264
84NANOG_21062744_ChIP-ChIP_HESCs_Human1.20288015
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19891286
86RARB_27405468_Chip-Seq_BRAIN_Mouse1.19344393
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19034908
88E2F1_21310950_ChIP-Seq_MCF-7_Human1.18923529
89THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17776520
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16323332
91TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15617063
92TET1_21490601_ChIP-Seq_MESCs_Mouse1.15593332
93GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.15264469
94TCF3_18692474_ChIP-Seq_MESCs_Mouse1.14694054
95SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14688393
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13731396
97SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13724668
98* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.13254205
99E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13152437
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.12723210
101DROSHA_22980978_ChIP-Seq_HELA_Human1.12400317
102CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11852844
103CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11837415
104POU5F1_16518401_ChIP-PET_MESCs_Mouse1.11604562
105* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10737742
106P68_20966046_ChIP-Seq_HELA_Human1.10415009
107BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10406594
108TBX20_22328084_ChIP-Seq_HEART_Mouse1.09170171
109TBX20_22080862_ChIP-Seq_HEART_Mouse1.09170171
110STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.08373526
111CTCF_27219007_Chip-Seq_Bcells_Human1.07968624
112CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06976515
113TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06830017
114* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.05861739
115FOXO3_23340844_ChIP-Seq_DLD1_Human1.05322140
116CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04517848
117SA1_27219007_Chip-Seq_ERYTHROID_Human1.04025404
118ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03420230
119ELF1_20517297_ChIP-Seq_JURKAT_Human1.03040101
120UBF1/2_26484160_Chip-Seq_HMECs_Human1.03018625
121GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01336517
122DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00732738
123* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00332175
124SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99030874
125RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98944859
126* TET1_21451524_ChIP-Seq_MESCs_Mouse0.98903259
127* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.98853146
128CHD1_26751641_Chip-Seq_LNCaP_Human0.98585999
129TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98402892
130NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.98353701
131TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97990176
132CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96851846
133TP53_22127205_ChIP-Seq_IMR90_Human0.96037967
134TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.95966233
135RUNX1_27514584_Chip-Seq_MCF-7_Human0.95690415
136ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94103815
137FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.92939990
138MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.92868821
139ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92061861
140TP53_23651856_ChIP-Seq_MEFs_Mouse0.91336595
141RING1B_27294783_Chip-Seq_NPCs_Mouse0.90664256
142PKCTHETA_26484144_Chip-Seq_BREAST_Human0.90292908

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo4.45212912
2MP0003705_abnormal_hypodermis_morpholog4.06060122
3MP0005360_urolithiasis3.61142099
4MP0002139_abnormal_hepatobiliary_system2.94823398
5MP0004147_increased_porphyrin_level2.91869772
6MP0005451_abnormal_body_composition2.86399558
7MP0010352_gastrointestinal_tract_polyps2.82217115
8MP0005076_abnormal_cell_differentiation2.72933585
9MP0004264_abnormal_extraembryonic_tissu2.60515080
10MP0005085_abnormal_gallbladder_physiolo2.49205251
11MP0005409_darkened_coat_color2.41852732
12MP0005365_abnormal_bile_salt2.41264563
13MP0004858_abnormal_nervous_system2.34988426
14MP0004233_abnormal_muscle_weight2.28863810
15MP0003111_abnormal_nucleus_morphology2.21073157
16MP0000678_abnormal_parathyroid_gland2.20689996
17MP0009278_abnormal_bone_marrow2.16148956
18MP0003252_abnormal_bile_duct2.14479298
19MP0005257_abnormal_intraocular_pressure2.13818132
20MP0005083_abnormal_biliary_tract2.08609754
21MP0004185_abnormal_adipocyte_glucose1.92447652
22MP0010307_abnormal_tumor_latency1.92382736
23MP0002249_abnormal_larynx_morphology1.91112941
24MP0003942_abnormal_urinary_system1.81588404
25MP0002089_abnormal_postnatal_growth/wei1.81331327
26MP0000534_abnormal_ureter_morphology1.80247706
27MP0005670_abnormal_white_adipose1.76990573
28MP0010329_abnormal_lipoprotein_level1.76684380
29MP0010368_abnormal_lymphatic_system1.73896374
30MP0001545_abnormal_hematopoietic_system1.71835095
31MP0005397_hematopoietic_system_phenotyp1.71835095
32MP0010234_abnormal_vibrissa_follicle1.71065846
33MP0002653_abnormal_ependyma_morphology1.70743906
34MP0003122_maternal_imprinting1.67384040
35MP0001849_ear_inflammation1.65158605
36MP0003300_gastrointestinal_ulcer1.65096462
37MP0008057_abnormal_DNA_replication1.64833683
38MP0003283_abnormal_digestive_organ1.64751175
39MP0000537_abnormal_urethra_morphology1.62620171
40MP0002086_abnormal_extraembryonic_tissu1.58561495
41MP0004197_abnormal_fetal_growth/weight/1.58282048
42MP0003879_abnormal_hair_cell1.57968123
43MP0000609_abnormal_liver_physiology1.56206930
44MP0004510_myositis1.52255275
45MP0005666_abnormal_adipose_tissue1.51463260
46MP0001348_abnormal_lacrimal_gland1.51052295
47MP0009840_abnormal_foam_cell1.49940499
48MP0008961_abnormal_basal_metabolism1.47493935
49MP0009053_abnormal_anal_canal1.47136426
50MP0001730_embryonic_growth_arrest1.46287141
51MP0003566_abnormal_cell_adhesion1.46249182
52MP0003077_abnormal_cell_cycle1.46063664
53MP0001666_abnormal_nutrient_absorption1.44213244
54MP0008875_abnormal_xenobiotic_pharmacok1.43563533
55MP0001672_abnormal_embryogenesis/_devel1.42929918
56MP0005380_embryogenesis_phenotype1.42929918
57MP0004957_abnormal_blastocyst_morpholog1.41961524
58MP0003172_abnormal_lysosome_physiology1.40160415
59MP0010094_abnormal_chromosome_stability1.38761130
60MP0003984_embryonic_growth_retardation1.38483724
61MP0002088_abnormal_embryonic_growth/wei1.37986974
62MP0000350_abnormal_cell_proliferation1.36445136
63MP0003329_amyloid_beta_deposits1.35789551
64MP0002877_abnormal_melanocyte_morpholog1.33323100
65MP0005058_abnormal_lysosome_morphology1.30465255
66MP0000566_synostosis1.28283229
67MP0002084_abnormal_developmental_patter1.25487749
68MP0005410_abnormal_fertilization1.22687715
69MP0003119_abnormal_digestive_system1.18650882
70MP0001697_abnormal_embryo_size1.18385645
71MP0005375_adipose_tissue_phenotype1.15757683
72MP0009780_abnormal_chondrocyte_physiolo1.15452827
73MP0004272_abnormal_basement_membrane1.15337518
74MP0009672_abnormal_birth_weight1.13308795
75MP0002896_abnormal_bone_mineralization1.12639452
76MP0005023_abnormal_wound_healing1.12049141
77MP0002085_abnormal_embryonic_tissue1.08344981
78MP0003453_abnormal_keratinocyte_physiol1.07541233
79MP0003115_abnormal_respiratory_system1.06203691
80MP0002080_prenatal_lethality1.05771814
81MP0008438_abnormal_cutaneous_collagen1.05488125
82MP0003191_abnormal_cellular_cholesterol1.05396029
83MP0000428_abnormal_craniofacial_morphol1.01640104
84MP0006138_congestive_heart_failure1.00859937
85MP0008260_abnormal_autophagy1.00533260
86MP0000598_abnormal_liver_morphology1.00493304
87MP0003806_abnormal_nucleotide_metabolis1.00108391
88MP0009384_cardiac_valve_regurgitation0.99976777
89MP0009703_decreased_birth_body0.99804835
90MP0005501_abnormal_skin_physiology0.96410310
91MP0003890_abnormal_embryonic-extraembry0.96303359
92MP0003868_abnormal_feces_composition0.96252496
93MP0000767_abnormal_smooth_muscle0.95938595
94MP0004859_abnormal_synaptic_plasticity0.93619580
95MP0008770_decreased_survivor_rate0.93354741
96MP0000003_abnormal_adipose_tissue0.93274743
97MP0003123_paternal_imprinting0.93188336
98MP0003693_abnormal_embryo_hatching0.90348155
99MP0005319_abnormal_enzyme/_coenzyme0.88627850
100MP0002118_abnormal_lipid_homeostasis0.85606281
101MP0002970_abnormal_white_adipose0.85526023
102MP0003303_peritoneal_inflammation0.84334659
103MP0003943_abnormal_hepatobiliary_system0.83850866
104MP0004087_abnormal_muscle_fiber0.83498461
105MP0002925_abnormal_cardiovascular_devel0.82758174
106MP0003828_pulmonary_edema0.82518427
107MP0009115_abnormal_fat_cell0.82422597
108MP0003861_abnormal_nervous_system0.80269119
109MP0002168_other_aberrant_phenotype0.79993148
110MP0010630_abnormal_cardiac_muscle0.79369913
111MP0000490_abnormal_crypts_of0.79290096
112MP0000477_abnormal_intestine_morphology0.78949839
113MP0009931_abnormal_skin_appearance0.78947978
114MP0000751_myopathy0.78809767
115MP0003045_fibrosis0.78437395
116MP0000266_abnormal_heart_morphology0.77863543
117MP0001614_abnormal_blood_vessel0.77195462
118MP0002019_abnormal_tumor_incidence0.75037001
119MP0002254_reproductive_system_inflammat0.74715407
120MP0003634_abnormal_glial_cell0.74432098
121MP0009643_abnormal_urine_homeostasis0.73675192
122MP0000313_abnormal_cell_death0.72780172
123MP0003385_abnormal_body_wall0.72039533
124MP0004270_analgesia0.71496788
125MP0000432_abnormal_head_morphology0.71342566
126MP0002998_abnormal_bone_remodeling0.70241637
127MP0003567_abnormal_fetal_cardiomyocyte0.70117263
128MP0008995_early_reproductive_senescence0.69450321
129MP0000733_abnormal_muscle_development0.68792142
130MP0000759_abnormal_skeletal_muscle0.68514943
131MP0002116_abnormal_craniofacial_bone0.68287754
132MP0002092_abnormal_eye_morphology0.67757279
133MP0008775_abnormal_heart_ventricle0.67553440
134MP0002060_abnormal_skin_morphology0.66915912
135MP0002796_impaired_skin_barrier0.66640256
136MP0002971_abnormal_brown_adipose0.65581471
137MP0005621_abnormal_cell_physiology0.65372768
138MP0000569_abnormal_digit_pigmentation0.64229030
139MP0001915_intracranial_hemorrhage0.62904793
140MP0005332_abnormal_amino_acid0.62631847
141MP0002697_abnormal_eye_size0.62421915
142MP0010030_abnormal_orbit_morphology0.62392287
143MP0001929_abnormal_gametogenesis0.61153415
144MP0003091_abnormal_cell_migration0.60133756
145MP0003878_abnormal_ear_physiology0.59989726
146MP0005377_hearing/vestibular/ear_phenot0.59989726
147MP0004019_abnormal_vitamin_homeostasis0.59778773

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)6.33974040
2Hypochromic microcytic anemia (HP:0004840)5.98070910
3Acanthocytosis (HP:0001927)4.91500883
4Reticulocytosis (HP:0001923)4.85665717
5Abnormality of the heme biosynthetic pathway (HP:0010472)4.52507381
6Obstructive sleep apnea (HP:0002870)3.48880757
7Cholelithiasis (HP:0001081)3.44330797
8Insomnia (HP:0100785)3.25795783
9Abnormal gallbladder morphology (HP:0012437)3.06411238
10Broad face (HP:0000283)3.04296972
11Abnormality of the lower motor neuron (HP:0002366)3.02243309
12Flat acetabular roof (HP:0003180)2.94992634
13Diaphragmatic weakness (HP:0009113)2.89141267
14Hypochromic anemia (HP:0001931)2.85452219
15Abnormality of the distal phalanx of the thumb (HP:0009617)2.80495591
16Ependymoma (HP:0002888)2.75498533
17Abnormality of reticulocytes (HP:0004312)2.74380941
18Hyperbilirubinemia (HP:0002904)2.73012148
19Polycythemia (HP:0001901)2.72779322
20Cerebral aneurysm (HP:0004944)2.68096455
21Heterotopia (HP:0002282)2.66696896
22Male infertility (HP:0003251)2.65766613
23Ileus (HP:0002595)2.62983328
24Deep venous thrombosis (HP:0002625)2.62099174
25Abnormality of the fingertips (HP:0001211)2.53129978
26Ulnar bowing (HP:0003031)2.49738449
27Pseudobulbar signs (HP:0002200)2.44670205
28Germ cell neoplasia (HP:0100728)2.39134703
29Abnormality of the aortic arch (HP:0012303)2.39033047
30Abnormality of monocarboxylic acid metabolism (HP:0010996)2.33719088
31Intrahepatic cholestasis (HP:0001406)2.31974555
32Asymmetry of the thorax (HP:0001555)2.29657808
33Hand muscle atrophy (HP:0009130)2.27963772
34Abnormality of the astrocytes (HP:0100707)2.26982657
35Astrocytoma (HP:0009592)2.26982657
36Osteomalacia (HP:0002749)2.25852126
37Macroorchidism (HP:0000053)2.25023420
38Abnormality of the gallbladder (HP:0005264)2.24501271
39Hyperacusis (HP:0010780)2.24165714
40Xanthomatosis (HP:0000991)2.21313805
41Global brain atrophy (HP:0002283)2.19222897
42Rectal prolapse (HP:0002035)2.18980182
43Back pain (HP:0003418)2.15617312
44Upper limb amyotrophy (HP:0009129)2.14713647
45Distal upper limb amyotrophy (HP:0007149)2.14713647
46Hepatocellular carcinoma (HP:0001402)2.13321043
47Thin bony cortex (HP:0002753)2.13210154
48Rib fusion (HP:0000902)2.07778665
49Disproportionate tall stature (HP:0001519)2.07746472
50Bronchomalacia (HP:0002780)2.07267186
51Abnormal ossification of hand bones (HP:0005921)2.06665607
52Neonatal short-limb short stature (HP:0008921)2.01430462
53Autoimmune thrombocytopenia (HP:0001973)1.99350226
54Pustule (HP:0200039)1.99336397
55Aneurysm (HP:0002617)1.97558452
56Turricephaly (HP:0000262)1.96851645
57Long palpebral fissure (HP:0000637)1.96077875
58Renovascular hypertension (HP:0100817)1.96038303
59Metaphyseal cupping (HP:0003021)1.95537792
60Arterial tortuosity (HP:0005116)1.94170978
61Abnormality of the phalanges of the hallux (HP:0010057)1.93955392
62Abnormal gallbladder physiology (HP:0012438)1.93762587
63Cholecystitis (HP:0001082)1.93762587
64Paralysis (HP:0003470)1.93576339
65Genu recurvatum (HP:0002816)1.92732844
66Abnormality of the nasal septum (HP:0000419)1.92351738
67Hypobetalipoproteinemia (HP:0003563)1.91813754
68Testicular neoplasm (HP:0010788)1.91779160
69Broad palm (HP:0001169)1.90049703
70Abnormality of carpal bone ossification (HP:0006257)1.87675451
71Achilles tendon contracture (HP:0001771)1.87496216
72Ankle contracture (HP:0006466)1.87358447
73Renal duplication (HP:0000075)1.87187235
74Abnormality of glutamine family amino acid metabolism (HP:0010902)1.86516894
75Dislocated radial head (HP:0003083)1.86261244
76Abnormality of the Achilles tendon (HP:0005109)1.85770236
77Premature rupture of membranes (HP:0001788)1.84751909
78Advanced eruption of teeth (HP:0006288)1.84437537
79Mitral valve prolapse (HP:0001634)1.84082777
80Abnormality of sulfur amino acid metabolism (HP:0004339)1.82867855
81Volvulus (HP:0002580)1.82556273
82Vertebral arch anomaly (HP:0008438)1.81892850
83Basal cell carcinoma (HP:0002671)1.81830003
84Vascular tortuosity (HP:0004948)1.81294702
85Shallow orbits (HP:0000586)1.79942092
86Short 5th finger (HP:0009237)1.79860269
87Arnold-Chiari malformation (HP:0002308)1.79853736
88Hyperparathyroidism (HP:0000843)1.79667274
89Increased connective tissue (HP:0009025)1.79578389
90Protrusio acetabuli (HP:0003179)1.78778197
91Cerebral inclusion bodies (HP:0100314)1.78534766
92Malnutrition (HP:0004395)1.77604651
93Cervical subluxation (HP:0003308)1.77286310
94Enlarged penis (HP:0000040)1.76216076
95Dysmetric saccades (HP:0000641)1.75922256
96Decreased motor nerve conduction velocity (HP:0003431)1.75602099
97Short nail (HP:0001799)1.75381952
98Urethral obstruction (HP:0000796)1.75218819
99Lymphangioma (HP:0100764)1.74878286
100Spastic diplegia (HP:0001264)1.74687752
101Precocious puberty (HP:0000826)1.74530375
102Increased nuchal translucency (HP:0010880)1.74143490
103Hemorrhage of the eye (HP:0011885)1.73815623
104Distal lower limb amyotrophy (HP:0008944)1.73710505
105Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.73282879
106Myocardial infarction (HP:0001658)1.73220436
107Limited elbow extension (HP:0001377)1.72659283
108Shawl scrotum (HP:0000049)1.72590260
109Neoplasm of striated muscle (HP:0009728)1.72042082
110Impulsivity (HP:0100710)1.71500941
111Increased mean platelet volume (HP:0011877)1.71321962
112Broad thumb (HP:0011304)1.70845088
113Flattened epiphyses (HP:0003071)1.70617920
114Abnormality of the radial head (HP:0003995)1.69733629
115High pitched voice (HP:0001620)1.69035175
116Hypolipoproteinemia (HP:0010981)1.68846998
117Long eyelashes (HP:0000527)1.68061958
118Hypoalphalipoproteinemia (HP:0003233)1.67103909
119Abnormal tarsal ossification (HP:0008369)1.66768751
120Sandal gap (HP:0001852)1.66155561
121Mitral regurgitation (HP:0001653)1.66146352
122Abnormal hand bone ossification (HP:0010660)1.65273715
123Bowel incontinence (HP:0002607)1.65055107
124Selective tooth agenesis (HP:0001592)1.65022550
125Joint laxity (HP:0001388)1.63818975
126Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.63741550
127Short 4th metacarpal (HP:0010044)1.63741550
128Right ventricular cardiomyopathy (HP:0011663)1.63669930
129Mildly elevated creatine phosphokinase (HP:0008180)1.63149158
130Patellar dislocation (HP:0002999)1.62406116
131Hyperkalemia (HP:0002153)1.62354741
132Abnormality of the 4th metacarpal (HP:0010012)1.61503606
133Abnormality of transition element cation homeostasis (HP:0011030)1.61428636
134Elfin facies (HP:0004428)1.61159383
135Deviation of the thumb (HP:0009603)1.60989646
136Vertebral compression fractures (HP:0002953)1.60154365
137Complement deficiency (HP:0004431)1.60051683
138Prominent nose (HP:0000448)1.60010479
139Glioma (HP:0009733)1.59832204
140Sparse lateral eyebrow (HP:0005338)1.58920304
141Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.58508965
142Deep palmar crease (HP:0006191)1.57906745
143Short phalanx of the thumb (HP:0009660)1.57244558
144Epidermoid cyst (HP:0200040)1.57015863
145Neurofibrillary tangles (HP:0002185)1.56900201
146Generalized hyperpigmentation (HP:0007440)1.56497490
147Hypercholesterolemia (HP:0003124)1.56250698
148Multiple enchondromatosis (HP:0005701)1.56047639
149Esophageal varix (HP:0002040)1.56024604
150Asymmetric septal hypertrophy (HP:0001670)1.55911410
151Broad metatarsal (HP:0001783)1.55550989
152Abnormality of the thoracic spine (HP:0100711)1.55383578
153Hepatoblastoma (HP:0002884)1.55329801
154Facial hemangioma (HP:0000329)1.54982973
155Blue sclerae (HP:0000592)1.53627349
156Hyperextensible skin (HP:0000974)1.51953924
157Neonatal death (HP:0003811)1.51881728
158Hypercortisolism (HP:0001578)1.51619147
159Truncal obesity (HP:0001956)1.51526009
160Onion bulb formation (HP:0003383)1.50572281
161Abnormal ventriculo-arterial connection (HP:0011563)1.48113145
162Transposition of the great arteries (HP:0001669)1.48113145
163Abnormal connection of the cardiac segments (HP:0011545)1.48113145
164Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.47749304
165Coxa vara (HP:0002812)1.47466057
166Segmental peripheral demyelination/remyelination (HP:0003481)1.47071733
167Abnormality of the acetabulum (HP:0003170)1.46388698
168Thin ribs (HP:0000883)1.46113977
169Obsessive-compulsive behavior (HP:0000722)1.45865635
170Termporal pattern (HP:0011008)1.45516273
171Insidious onset (HP:0003587)1.45516273
172Abnormal large intestine physiology (HP:0012700)1.44540913

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.75091963
2MAP3K103.66677267
3TRIB33.38948392
4PRPF4B3.28225462
5ICK2.88521793
6ERN12.64943463
7PKN22.56486819
8EEF2K2.52459154
9IRAK32.40887351
10SMG12.20940103
11LATS12.07935290
12NEK22.05055285
13MAP3K92.02824862
14RIPK11.93048174
15GRK61.71661953
16CDC71.69823512
17TYRO31.66679003
18BRD41.62445005
19CAMK1D1.61520013
20TAOK11.60069363
21CDK41.56994696
22STK101.54973731
23BMX1.54712350
24CDK61.54491532
25MTOR1.54047915
26PDGFRA1.54037823
27SIK11.52653814
28TAOK21.46085662
29PRKD31.45734655
30MARK21.41480025
31EPHB11.41069338
32STK41.40714980
33PTK61.39379044
34TTK1.33609183
35STK31.26795345
36CAMK1G1.24699018
37LATS21.17405998
38CDK71.13836178
39MAPK111.09749253
40DDR21.08705196
41PDPK11.07609404
42MAP3K81.06714315
43MST1R1.05236873
44DYRK1B1.04260420
45RPS6KA21.01054991
46MAP3K10.98711021
47FGFR30.96145677
48ALK0.94559903
49PIM10.90404911
50NEK10.90185019
51TESK10.89262097
52MAP3K20.89097150
53PTK20.88833653
54NTRK10.87656637
55PAK40.86897610
56CDK90.86065364
57RPS6KB20.86036493
58PRKAA10.85345163
59CHEK20.84946353
60MAP3K110.83369655
61AKT30.83306948
62SIK20.82196810
63CHEK10.81897171
64CDC42BPA0.81732237
65SGK2230.79573119
66SGK4940.79573119
67EPHA20.78084884
68PRKD20.77848150
69DMPK0.76786116
70LMTK20.74938867
71MET0.73475303
72HIPK20.73080987
73STK38L0.71643911
74SGK20.69982886
75ERBB20.69605295
76FGFR40.68554184
77MELK0.67423226
78KSR20.66679087
79PNCK0.66532264
80PDK10.65455108
81MAP3K70.65448350
82TTN0.63697104
83ATM0.63677161
84STK380.62892298
85CDK20.62342554
86RPS6KL10.62164494
87RPS6KC10.62164494
88AURKB0.61980720
89PAK20.59899579
90PLK10.59893370
91TAOK30.58028435
92NTRK30.57688894
93MAP2K30.56877390
94DYRK30.56678621
95CSK0.56359070
96JAK20.55986725
97MAPKAPK30.55864820
98LRRK20.54916027
99PRKAA20.53437784
100WNK10.53346537
101MAP4K10.52448534
102SGK30.52068162
103FLT30.51926916
104PDGFRB0.51796968
105CAMK40.50504032
106MAP3K130.50234965
107AKT20.49868321
108ATR0.48793920
109BRAF0.48504610
110MAP3K60.47406474
111TGFBR20.45685624
112FRK0.45392828
113MAPK100.44222318
114MAP2K20.43631273
115MAPK10.43181759
116SGK10.42491858
117IRAK20.41861799
118PTK2B0.41372275
119RPS6KA60.41103482
120CHUK0.41043331
121MAPK140.40926112
122PRKG20.40518638
123RPS6KA10.39992205
124KSR10.39530526
125CDK10.38870159
126BRSK10.38681537
127MAP3K30.38171001
128SCYL20.38022402
129GSK3A0.37732028
130EIF2AK10.37578306
131CAMKK10.37067406
132MATK0.36992691
133RET0.36525743
134TLK10.36514984
135AKT10.36241582
136FGFR10.34650970
137CSNK1D0.33947039
138GSK3B0.33244826
139NLK0.31337718
140SIK30.31269854
141MAPK80.31231178

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.85504724
2Lysine degradation_Homo sapiens_hsa003102.42034903
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.30181762
4Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.23606277
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.02872889
6Arginine biosynthesis_Homo sapiens_hsa002201.94908264
7Vitamin B6 metabolism_Homo sapiens_hsa007501.94179431
8Fat digestion and absorption_Homo sapiens_hsa049751.84353123
9Primary bile acid biosynthesis_Homo sapiens_hsa001201.72011657
10Bile secretion_Homo sapiens_hsa049761.67842613
11Tryptophan metabolism_Homo sapiens_hsa003801.67066190
12Selenocompound metabolism_Homo sapiens_hsa004501.64949255
13PPAR signaling pathway_Homo sapiens_hsa033201.60420322
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.51486386
15Renal cell carcinoma_Homo sapiens_hsa052111.49074818
16mTOR signaling pathway_Homo sapiens_hsa041501.44565848
17Prion diseases_Homo sapiens_hsa050201.43846733
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.42678861
19ErbB signaling pathway_Homo sapiens_hsa040121.42170686
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39656531
21Bladder cancer_Homo sapiens_hsa052191.39037448
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34781538
23Fatty acid biosynthesis_Homo sapiens_hsa000611.33144416
24Caffeine metabolism_Homo sapiens_hsa002321.31543411
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.29128561
26ABC transporters_Homo sapiens_hsa020101.29041114
27Fatty acid degradation_Homo sapiens_hsa000711.25474164
28Chronic myeloid leukemia_Homo sapiens_hsa052201.22093673
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20261126
30GnRH signaling pathway_Homo sapiens_hsa049121.20213822
31Dorso-ventral axis formation_Homo sapiens_hsa043201.19469371
32Neurotrophin signaling pathway_Homo sapiens_hsa047221.19242481
33Insulin resistance_Homo sapiens_hsa049311.19072063
34Estrogen signaling pathway_Homo sapiens_hsa049151.15956623
35AMPK signaling pathway_Homo sapiens_hsa041521.15385194
36Complement and coagulation cascades_Homo sapiens_hsa046101.15166727
37Biosynthesis of amino acids_Homo sapiens_hsa012301.15078680
38Systemic lupus erythematosus_Homo sapiens_hsa053221.14001628
39Long-term potentiation_Homo sapiens_hsa047201.09080016
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08737956
41Other glycan degradation_Homo sapiens_hsa005111.08592821
42Longevity regulating pathway - mammal_Homo sapiens_hsa042111.08316080
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.07052509
44Cell cycle_Homo sapiens_hsa041101.06050744
45Choline metabolism in cancer_Homo sapiens_hsa052311.03558590
46Inositol phosphate metabolism_Homo sapiens_hsa005621.03296284
47Small cell lung cancer_Homo sapiens_hsa052221.03136630
48Non-small cell lung cancer_Homo sapiens_hsa052231.02899830
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01996868
50Glycerolipid metabolism_Homo sapiens_hsa005611.01750776
51Fatty acid metabolism_Homo sapiens_hsa012121.01100551
52Phospholipase D signaling pathway_Homo sapiens_hsa040721.00991527
53Prolactin signaling pathway_Homo sapiens_hsa049171.00805623
54One carbon pool by folate_Homo sapiens_hsa006700.99851377
55mRNA surveillance pathway_Homo sapiens_hsa030150.97591683
56Adherens junction_Homo sapiens_hsa045200.96637849
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93068233
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92400105
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91946699
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91040215
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.90422301
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89168317
63Notch signaling pathway_Homo sapiens_hsa043300.88553046
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.88519951
65MicroRNAs in cancer_Homo sapiens_hsa052060.88449185
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87126658
67Amoebiasis_Homo sapiens_hsa051460.86808775
68Colorectal cancer_Homo sapiens_hsa052100.86174767
69Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86159968
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85647207
71Fructose and mannose metabolism_Homo sapiens_hsa000510.85130569
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85043795
73Carbon metabolism_Homo sapiens_hsa012000.83449968
74Sulfur relay system_Homo sapiens_hsa041220.81226715
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80956535
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77762929
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77754101
78Tight junction_Homo sapiens_hsa045300.76902167
79Pyruvate metabolism_Homo sapiens_hsa006200.76782404
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76332364
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.75935060
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74967302
83Endocytosis_Homo sapiens_hsa041440.74962371
84Glucagon signaling pathway_Homo sapiens_hsa049220.74489820
85Melanogenesis_Homo sapiens_hsa049160.74292061
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73852747
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73252370
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.72882975
89Hepatitis B_Homo sapiens_hsa051610.72791338
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72434316
91Starch and sucrose metabolism_Homo sapiens_hsa005000.71353374
92Folate biosynthesis_Homo sapiens_hsa007900.71307709
93Endometrial cancer_Homo sapiens_hsa052130.71149407
94Insulin signaling pathway_Homo sapiens_hsa049100.70563770
95Hepatitis C_Homo sapiens_hsa051600.70421181
96MAPK signaling pathway_Homo sapiens_hsa040100.69134954
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.68472127
98Pancreatic cancer_Homo sapiens_hsa052120.68315219
99Viral carcinogenesis_Homo sapiens_hsa052030.68232285
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68175940
101Type II diabetes mellitus_Homo sapiens_hsa049300.68134620
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67976266
103Acute myeloid leukemia_Homo sapiens_hsa052210.67768722
104p53 signaling pathway_Homo sapiens_hsa041150.67051815
105Thyroid hormone synthesis_Homo sapiens_hsa049180.66997400
106Sphingolipid metabolism_Homo sapiens_hsa006000.66601566
107Thyroid cancer_Homo sapiens_hsa052160.66089768
108Protein digestion and absorption_Homo sapiens_hsa049740.65133815
109Axon guidance_Homo sapiens_hsa043600.64661674
110B cell receptor signaling pathway_Homo sapiens_hsa046620.64560689
111Prostate cancer_Homo sapiens_hsa052150.64387136
112Hippo signaling pathway_Homo sapiens_hsa043900.63649571
113HIF-1 signaling pathway_Homo sapiens_hsa040660.63604357
114Proteoglycans in cancer_Homo sapiens_hsa052050.61637073
115Wnt signaling pathway_Homo sapiens_hsa043100.61484961
116Glioma_Homo sapiens_hsa052140.61182966
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61060866
118beta-Alanine metabolism_Homo sapiens_hsa004100.60649138
119TNF signaling pathway_Homo sapiens_hsa046680.60514379
120Glycosaminoglycan degradation_Homo sapiens_hsa005310.60189934
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60065930
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60060386
123RNA transport_Homo sapiens_hsa030130.59225154
124Galactose metabolism_Homo sapiens_hsa000520.58787264
125ECM-receptor interaction_Homo sapiens_hsa045120.58661064
126Vitamin digestion and absorption_Homo sapiens_hsa049770.58603014
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.58031375
128Rap1 signaling pathway_Homo sapiens_hsa040150.56546441
129Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56312315
130Basal cell carcinoma_Homo sapiens_hsa052170.55645382
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54558284
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54541972
133Gap junction_Homo sapiens_hsa045400.54512997
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.54267942
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.54043416
136cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53966197
137Mineral absorption_Homo sapiens_hsa049780.53064129
138Renin-angiotensin system_Homo sapiens_hsa046140.52724873
139Pentose phosphate pathway_Homo sapiens_hsa000300.52676130
140VEGF signaling pathway_Homo sapiens_hsa043700.52013681
141Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51441354
142Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50954360
143Dilated cardiomyopathy_Homo sapiens_hsa054140.50924454
144Cholinergic synapse_Homo sapiens_hsa047250.50325803
145TGF-beta signaling pathway_Homo sapiens_hsa043500.49702816
146Propanoate metabolism_Homo sapiens_hsa006400.49042192
147Phenylalanine metabolism_Homo sapiens_hsa003600.48652906
148Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48221198
149Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47739312
150FoxO signaling pathway_Homo sapiens_hsa040680.46680350
151Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46252470
152Staphylococcus aureus infection_Homo sapiens_hsa051500.45733772
153Focal adhesion_Homo sapiens_hsa045100.44718420
154Chemical carcinogenesis_Homo sapiens_hsa052040.44227709
155HTLV-I infection_Homo sapiens_hsa051660.42819266

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