BRSK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)7.03636038
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.61003204
3locomotory exploration behavior (GO:0035641)6.58592388
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.06843232
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.87088136
6vocalization behavior (GO:0071625)5.62125646
7synaptic vesicle docking involved in exocytosis (GO:0016081)5.56118535
8glutamate secretion (GO:0014047)5.49441969
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.43371212
10synaptic vesicle exocytosis (GO:0016079)5.41146689
11regulation of synaptic vesicle exocytosis (GO:2000300)5.31980238
12regulation of glutamate receptor signaling pathway (GO:1900449)5.12550152
13layer formation in cerebral cortex (GO:0021819)5.08428899
14exploration behavior (GO:0035640)4.89234352
15regulation of neuronal synaptic plasticity (GO:0048168)4.88855943
16regulation of synapse structural plasticity (GO:0051823)4.85040641
17regulation of long-term neuronal synaptic plasticity (GO:0048169)4.82867392
18cerebellar granule cell differentiation (GO:0021707)4.77363960
19regulation of synaptic vesicle transport (GO:1902803)4.73037829
20protein localization to synapse (GO:0035418)4.71597999
21dendritic spine morphogenesis (GO:0060997)4.70913178
22* neurotransmitter secretion (GO:0007269)4.53387513
23ionotropic glutamate receptor signaling pathway (GO:0035235)4.49400614
24neuronal action potential propagation (GO:0019227)4.32913568
25gamma-aminobutyric acid transport (GO:0015812)4.28862393
26amino acid import (GO:0043090)4.26874498
27neurotransmitter-gated ion channel clustering (GO:0072578)4.22815652
28central nervous system myelination (GO:0022010)4.22205249
29axon ensheathment in central nervous system (GO:0032291)4.22205249
30proline transport (GO:0015824)4.17406181
31sodium ion export (GO:0071436)4.11651579
32synaptic transmission, glutamatergic (GO:0035249)4.08939656
33potassium ion homeostasis (GO:0055075)4.05054883
34neuron cell-cell adhesion (GO:0007158)4.03786956
35cellular potassium ion homeostasis (GO:0030007)4.03607202
36long-term memory (GO:0007616)4.00985085
37neuromuscular process controlling balance (GO:0050885)4.00684983
38positive regulation of membrane potential (GO:0045838)3.98398020
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.94044466
40negative regulation of synaptic transmission, GABAergic (GO:0032229)3.92016139
41regulation of dendritic spine morphogenesis (GO:0061001)3.89199761
42activation of protein kinase A activity (GO:0034199)3.87859849
43glycine transport (GO:0015816)3.86609101
44regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.82880609
45glutamate receptor signaling pathway (GO:0007215)3.79560798
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.76224618
47neuron-neuron synaptic transmission (GO:0007270)3.74800001
48regulation of synapse maturation (GO:0090128)3.72467217
49auditory behavior (GO:0031223)3.70816448
50regulation of synaptic plasticity (GO:0048167)3.68438526
51positive regulation of synapse maturation (GO:0090129)3.67673750
52negative regulation of dendrite morphogenesis (GO:0050774)3.66318869
53* neurotransmitter transport (GO:0006836)3.58005994
54dendrite morphogenesis (GO:0048813)3.55757438
55positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.54975451
56prepulse inhibition (GO:0060134)3.54555920
57regulation of postsynaptic membrane potential (GO:0060078)3.53655036
58regulation of neurotransmitter secretion (GO:0046928)3.50034543
59positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.49533378
60response to auditory stimulus (GO:0010996)3.49335091
61regulation of ARF protein signal transduction (GO:0032012)3.48556592
62positive regulation of synaptic transmission, GABAergic (GO:0032230)3.47528964
63cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.46812446
64G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.44488269
65cell communication by electrical coupling (GO:0010644)3.43231886
66cellular sodium ion homeostasis (GO:0006883)3.41504504
67synaptic vesicle endocytosis (GO:0048488)3.40339760
68transmission of nerve impulse (GO:0019226)3.40257343
69dendritic spine organization (GO:0097061)3.38782578
70cytoskeletal anchoring at plasma membrane (GO:0007016)3.36911524
71neuronal ion channel clustering (GO:0045161)3.34620755
72L-amino acid import (GO:0043092)3.34147705
73positive regulation of neurotransmitter secretion (GO:0001956)3.33388482
74positive regulation of neurotransmitter transport (GO:0051590)3.32988003
75neuron recognition (GO:0008038)3.31380743
76* regulation of neurotransmitter levels (GO:0001505)3.31144963
77neuromuscular process controlling posture (GO:0050884)3.30006522
78regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.27779808
79cerebellar Purkinje cell differentiation (GO:0021702)3.27703286
80establishment of mitochondrion localization (GO:0051654)3.27032242
81presynaptic membrane organization (GO:0097090)3.26682286
82regulation of neurotransmitter transport (GO:0051588)3.25449821
83positive regulation of dendritic spine development (GO:0060999)3.23759883
84neuromuscular synaptic transmission (GO:0007274)3.22062664
85vesicle transport along microtubule (GO:0047496)3.21945521
86regulation of synaptic transmission, glutamatergic (GO:0051966)3.21881336
87regulation of dendritic spine development (GO:0060998)3.19710595
88cell differentiation in hindbrain (GO:0021533)3.16703370
89long-term synaptic potentiation (GO:0060291)3.16211312
90axonal fasciculation (GO:0007413)3.15441473
91presynaptic membrane assembly (GO:0097105)3.15066777
92gamma-aminobutyric acid signaling pathway (GO:0007214)3.13156230
93neuromuscular process (GO:0050905)3.11714891
94regulation of vesicle fusion (GO:0031338)3.11000824
95postsynaptic membrane organization (GO:0001941)3.10444158
96acidic amino acid transport (GO:0015800)3.09242565
97cerebellar Purkinje cell layer development (GO:0021680)3.08099142
98cell migration in hindbrain (GO:0021535)3.07959431
99positive regulation of dendrite development (GO:1900006)3.06349063
100positive regulation of dendritic spine morphogenesis (GO:0061003)3.05900540
101membrane depolarization during action potential (GO:0086010)3.05823059
102membrane depolarization (GO:0051899)3.05180118
103membrane hyperpolarization (GO:0060081)3.03323173
104regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.01095030
105learning (GO:0007612)3.00812350
106social behavior (GO:0035176)2.99542881
107intraspecies interaction between organisms (GO:0051703)2.99542881
108potassium ion import (GO:0010107)2.98508858
109positive regulation of synaptic transmission (GO:0050806)2.98407553
110establishment of synaptic vesicle localization (GO:0097480)2.98183319
111synaptic vesicle transport (GO:0048489)2.98183319
112regulation of synaptic transmission (GO:0050804)2.98054196
113vesicle docking involved in exocytosis (GO:0006904)2.97198926
114organelle transport along microtubule (GO:0072384)2.89820678
115regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.89705634
116positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.88309185
117innervation (GO:0060384)2.88073133
118establishment of nucleus localization (GO:0040023)2.85991412
119synapse assembly (GO:0007416)2.85962704
120regulation of voltage-gated calcium channel activity (GO:1901385)2.85306753
121axon cargo transport (GO:0008088)2.84177109

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.75463344
2RARB_27405468_Chip-Seq_BRAIN_Mouse3.08284374
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.01112450
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97176045
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.92294735
6DROSHA_22980978_ChIP-Seq_HELA_Human2.89619011
7REST_21632747_ChIP-Seq_MESCs_Mouse2.87967600
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.76304759
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.76304759
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.64287710
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64023470
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.58652365
13GBX2_23144817_ChIP-Seq_PC3_Human2.58219133
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.55967175
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.51352529
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44872565
17REST_18959480_ChIP-ChIP_MESCs_Mouse2.40126183
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.39262362
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38518116
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36928442
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.36856547
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.35274659
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.26127451
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.23604420
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.11099275
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.03892280
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.98438565
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.88808270
29* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87977227
30AR_21572438_ChIP-Seq_LNCaP_Human1.74871537
31KDM2B_26808549_Chip-Seq_K562_Human1.61681466
32ZFP281_18757296_ChIP-ChIP_E14_Mouse1.61038114
33DNAJC2_21179169_ChIP-ChIP_NT2_Human1.58238001
34RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.57566487
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54360227
36RING1B_27294783_Chip-Seq_ESCs_Mouse1.47003282
37* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43614665
38* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41924115
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40019801
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34101501
41WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32298074
42SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31123276
43ZFP281_27345836_Chip-Seq_ESCs_Mouse1.29492040
44SMAD4_21799915_ChIP-Seq_A2780_Human1.27567647
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26255287
46RING1B_27294783_Chip-Seq_NPCs_Mouse1.25638190
47GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25184379
48* AR_19668381_ChIP-Seq_PC3_Human1.21854308
49SOX2_21211035_ChIP-Seq_LN229_Gbm1.21567808
50CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18477961
51GATA1_26923725_Chip-Seq_HPCs_Mouse1.17774485
52ZNF274_21170338_ChIP-Seq_K562_Hela1.16051335
53* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14906082
54ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14131735
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14111086
56RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13794140
57EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12715951
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11616158
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11011949
60TP53_20018659_ChIP-ChIP_R1E_Mouse1.08801676
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07298542
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07217368
63P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06386734
64SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06319004
65RNF2_27304074_Chip-Seq_NSC_Mouse1.04953168
66TET1_21490601_ChIP-Seq_MESCs_Mouse1.04589051
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03391108
68CTCF_27219007_Chip-Seq_Bcells_Human1.02395195
69ESR2_21235772_ChIP-Seq_MCF-7_Human1.01597339
70DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01540752
71STAT3_23295773_ChIP-Seq_U87_Human1.01458031
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01405044
73SMAD_19615063_ChIP-ChIP_OVARY_Human0.99279785
74ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98966984
75SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98544930
76YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97940998
77DPY_21335234_ChIP-Seq_ESCs_Mouse0.97175372
78SMAD3_21741376_ChIP-Seq_EPCs_Human0.97124542
79SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96775386
80CREB1_26743006_Chip-Seq_LNCaP_Human0.96676556
81AR_25329375_ChIP-Seq_VCAP_Human0.96583145
82* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93881444
83SMAD3_21741376_ChIP-Seq_ESCs_Human0.93753631
84MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93641807
85SMAD4_21741376_ChIP-Seq_HESCs_Human0.93514592
86SMAD3_21741376_ChIP-Seq_HESCs_Human0.93512697
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91783884
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91486638
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90242181
90KDM2B_26808549_Chip-Seq_JURKAT_Human0.90121157
91ARNT_22903824_ChIP-Seq_MCF-7_Human0.88462153
92KLF4_19829295_ChIP-Seq_ESCs_Human0.88367976
93AHR_22903824_ChIP-Seq_MCF-7_Human0.88007432
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87695858
95LXR_22292898_ChIP-Seq_THP-1_Human0.87630285
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87451805
97P68_20966046_ChIP-Seq_HELA_Human0.87440943
98TCF4_23295773_ChIP-Seq_U87_Human0.87289138
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87146742
100KDM2B_26808549_Chip-Seq_DND41_Human0.86930257
101SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86831807
102SMC4_20622854_ChIP-Seq_HELA_Human0.86751798
103PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86720162
104OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86313729
105* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86192680
106RUNX1_26923725_Chip-Seq_HPCs_Mouse0.85233080
107TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.84029763
108RXR_22108803_ChIP-Seq_LS180_Human0.82912435
109OCT4_19829295_ChIP-Seq_ESCs_Human0.81823234
110MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.80502587
111CBX2_27304074_Chip-Seq_ESCs_Mouse0.80412071
112SMAD4_21741376_ChIP-Seq_ESCs_Human0.80012600
113CDX2_19796622_ChIP-Seq_MESCs_Mouse0.79380757
114CTNNB1_20460455_ChIP-Seq_HCT116_Human0.79279979
115OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79204236
116TOP2B_26459242_ChIP-Seq_MCF-7_Human0.79026099
117TP53_23651856_ChIP-Seq_MEFs_Mouse0.78847681
118NR3C1_21868756_ChIP-Seq_MCF10A_Human0.77337132
119P300_19829295_ChIP-Seq_ESCs_Human0.76805544
120ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.76802068
121TRIM28_21343339_ChIP-Seq_HEK293_Human0.76298267
122* TET1_21451524_ChIP-Seq_MESCs_Mouse0.73971379
123CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.73695158
124SOX3_22085726_ChIP-Seq_NPCs_Mouse0.72497477
125SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.72063693
126NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.71831178
127MYC_19915707_ChIP-ChIP_AK7_Human0.71155952
128PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.70957512

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.52680475
2MP0003635_abnormal_synaptic_transmissio4.40543421
3MP0003880_abnormal_central_pattern4.35402676
4MP0004270_analgesia4.02435065
5MP0002063_abnormal_learning/memory/cond3.50790529
6MP0009745_abnormal_behavioral_response3.45638562
7MP0002822_catalepsy3.34304561
8MP0002064_seizures3.18153007
9MP0005423_abnormal_somatic_nervous3.13137476
10MP0009046_muscle_twitch3.03337290
11MP0001968_abnormal_touch/_nociception2.81439370
12MP0002572_abnormal_emotion/affect_behav2.73692486
13MP0001486_abnormal_startle_reflex2.66355685
14* MP0002734_abnormal_mechanical_nocicepti2.48965647
15MP0002272_abnormal_nervous_system2.48922787
16MP0009780_abnormal_chondrocyte_physiolo2.30881060
17MP0004858_abnormal_nervous_system2.16276553
18MP0001501_abnormal_sleep_pattern2.12494397
19MP0008569_lethality_at_weaning2.11662793
20MP0004811_abnormal_neuron_physiology2.04643022
21MP0002733_abnormal_thermal_nociception2.03628293
22MP0003329_amyloid_beta_deposits2.02099357
23MP0002736_abnormal_nociception_after1.97872930
24MP0002909_abnormal_adrenal_gland1.96236696
25MP0001440_abnormal_grooming_behavior1.95905718
26MP0002735_abnormal_chemical_nociception1.87584020
27* MP0001970_abnormal_pain_threshold1.83913572
28MP0004885_abnormal_endolymph1.82901984
29MP0000778_abnormal_nervous_system1.82317481
30MP0003123_paternal_imprinting1.81642978
31MP0002067_abnormal_sensory_capabilities1.77278968
32MP0002557_abnormal_social/conspecific_i1.74209487
33MP0002184_abnormal_innervation1.72146820
34MP0000955_abnormal_spinal_cord1.71573735
35MP0005386_behavior/neurological_phenoty1.66078500
36MP0004924_abnormal_behavior1.66078500
37MP0003879_abnormal_hair_cell1.60268415
38MP0003633_abnormal_nervous_system1.50334697
39MP0005646_abnormal_pituitary_gland1.47687402
40* MP0002066_abnormal_motor_capabilities/c1.43688645
41* MP0002882_abnormal_neuron_morphology1.43571152
42MP0000569_abnormal_digit_pigmentation1.41170916
43MP0003787_abnormal_imprinting1.36252724
44MP0003283_abnormal_digestive_organ1.32572380
45MP0001984_abnormal_olfaction1.27167103
46MP0003631_nervous_system_phenotype1.24437965
47MP0003075_altered_response_to1.23779854
48MP0008961_abnormal_basal_metabolism1.19345334
49* MP0002152_abnormal_brain_morphology1.16659097
50MP0001502_abnormal_circadian_rhythm1.12374148
51MP0001177_atelectasis1.09026588
52MP0005645_abnormal_hypothalamus_physiol1.08068745
53MP0003690_abnormal_glial_cell1.07444687
54MP0004142_abnormal_muscle_tone1.05118614
55MP0001346_abnormal_lacrimal_gland1.02819178
56MP0005167_abnormal_blood-brain_barrier1.01823974
57MP0006276_abnormal_autonomic_nervous1.01629787
58MP0008872_abnormal_physiological_respon1.00141079
59MP0008874_decreased_physiological_sensi0.95485554
60MP0002069_abnormal_eating/drinking_beha0.95097770
61MP0000920_abnormal_myelination0.93245217
62MP0003634_abnormal_glial_cell0.93219056
63MP0001905_abnormal_dopamine_level0.92862539
64MP0002229_neurodegeneration0.90473076
65MP0000604_amyloidosis0.90410019
66MP0003632_abnormal_nervous_system0.89981548
67MP0000751_myopathy0.88710973
68MP0002638_abnormal_pupillary_reflex0.88678782
69MP0001529_abnormal_vocalization0.88569204
70MP0005623_abnormal_meninges_morphology0.87483918
71MP0000013_abnormal_adipose_tissue0.86362239
72MP0005499_abnormal_olfactory_system0.84059106
73MP0005394_taste/olfaction_phenotype0.84059106
74MP0010234_abnormal_vibrissa_follicle0.83082450
75MP0003122_maternal_imprinting0.82286712
76MP0003121_genomic_imprinting0.82128750
77MP0003172_abnormal_lysosome_physiology0.78602811
78MP0004085_abnormal_heartbeat0.77695642
79MP0002090_abnormal_vision0.76967681
80MP0005535_abnormal_body_temperature0.75380248
81MP0004145_abnormal_muscle_electrophysio0.74274371
82MP0000579_abnormal_nail_morphology0.74013515
83MP0004742_abnormal_vestibular_system0.69959221
84MP0004233_abnormal_muscle_weight0.67960584
85MP0003137_abnormal_impulse_conducting0.67641327
86MP0000631_abnormal_neuroendocrine_gland0.67302185
87MP0001963_abnormal_hearing_physiology0.66936845
88MP0005409_darkened_coat_color0.65753249
89MP0002752_abnormal_somatic_nervous0.64630854
90MP0002249_abnormal_larynx_morphology0.64578025
91MP0000566_synostosis0.63465134
92MP0003938_abnormal_ear_development0.63445302
93MP0004510_myositis0.63285234
94MP0005551_abnormal_eye_electrophysiolog0.63101371
95* MP0003861_abnormal_nervous_system0.62789974
96MP0001348_abnormal_lacrimal_gland0.60551921
97MP0001299_abnormal_eye_distance/0.60261498
98MP0001485_abnormal_pinna_reflex0.59840739
99MP0005187_abnormal_penis_morphology0.59129173
100MP0002089_abnormal_postnatal_growth/wei0.58968420
101MP0000026_abnormal_inner_ear0.58192139
102MP0008877_abnormal_DNA_methylation0.57376012
103MP0010769_abnormal_survival0.56911973
104MP0004130_abnormal_muscle_cell0.56022387
105MP0002653_abnormal_ependyma_morphology0.55814880
106MP0004147_increased_porphyrin_level0.55814114
107MP0001943_abnormal_respiration0.54043697
108MP0010768_mortality/aging0.52837856
109MP0010770_preweaning_lethality0.52347138
110MP0002082_postnatal_lethality0.52347138
111MP0010386_abnormal_urinary_bladder0.51445267
112MP0003956_abnormal_body_size0.51427004
113MP0001188_hyperpigmentation0.50893527

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.50774656
2Focal motor seizures (HP:0011153)6.52467247
3Focal seizures (HP:0007359)5.30276245
4Visual hallucinations (HP:0002367)5.28705026
5Action tremor (HP:0002345)4.25969677
6Epileptic encephalopathy (HP:0200134)4.13223898
7Ankle clonus (HP:0011448)4.11829693
8Supranuclear gaze palsy (HP:0000605)4.07730248
9Progressive cerebellar ataxia (HP:0002073)4.00636995
10Papilledema (HP:0001085)3.78494318
11Atonic seizures (HP:0010819)3.65660518
12Febrile seizures (HP:0002373)3.63877286
13Poor eye contact (HP:0000817)3.53592830
14Mutism (HP:0002300)3.53446219
15Impaired vibration sensation in the lower limbs (HP:0002166)3.53062999
16Generalized tonic-clonic seizures (HP:0002069)3.48256873
17Depression (HP:0000716)3.47355826
18Absence seizures (HP:0002121)3.45717638
19Abnormality of the lower motor neuron (HP:0002366)3.41165353
20Urinary bladder sphincter dysfunction (HP:0002839)3.39971007
21Postural instability (HP:0002172)3.26315054
22Impaired social interactions (HP:0000735)3.19350491
23Abnormal social behavior (HP:0012433)3.19350491
24Broad-based gait (HP:0002136)3.18089768
25Dysdiadochokinesis (HP:0002075)3.13691895
26Cerebral hypomyelination (HP:0006808)3.13682410
27Dialeptic seizures (HP:0011146)3.10972506
28Torticollis (HP:0000473)3.09097197
29Urinary urgency (HP:0000012)3.07701664
30Gaze-evoked nystagmus (HP:0000640)3.04958882
31Dysmetria (HP:0001310)2.97696991
32Anxiety (HP:0000739)2.95309118
33Annular pancreas (HP:0001734)2.92696411
34Abnormal eating behavior (HP:0100738)2.90813424
35Intention tremor (HP:0002080)2.86902220
36Insomnia (HP:0100785)2.86534901
37Megalencephaly (HP:0001355)2.86533891
38Genetic anticipation (HP:0003743)2.84858061
39Focal dystonia (HP:0004373)2.80175387
40Ventricular fibrillation (HP:0001663)2.79833470
41Spastic gait (HP:0002064)2.76822390
42Sleep apnea (HP:0010535)2.76274152
43Akinesia (HP:0002304)2.75655316
44Hemiplegia (HP:0002301)2.75641004
45Impaired smooth pursuit (HP:0007772)2.72206252
46Truncal ataxia (HP:0002078)2.72080883
47Pointed chin (HP:0000307)2.66889120
48Peripheral hypomyelination (HP:0007182)2.66768055
49Hemiparesis (HP:0001269)2.66456935
50Delusions (HP:0000746)2.64644356
51Neurofibrillary tangles (HP:0002185)2.63982909
52Amblyopia (HP:0000646)2.62040460
53Stereotypic behavior (HP:0000733)2.56103437
54Bradykinesia (HP:0002067)2.54834398
55Craniofacial dystonia (HP:0012179)2.51639985
56Cerebral inclusion bodies (HP:0100314)2.51345472
57Termporal pattern (HP:0011008)2.46713264
58Insidious onset (HP:0003587)2.46713264
59Bundle branch block (HP:0011710)2.46175299
60Diplopia (HP:0000651)2.45504029
61Abnormality of binocular vision (HP:0011514)2.45504029
62Amyotrophic lateral sclerosis (HP:0007354)2.41547672
63Abnormality of ocular smooth pursuit (HP:0000617)2.40757344
64Lower limb muscle weakness (HP:0007340)2.36881046
65Obstructive sleep apnea (HP:0002870)2.35905688
66Impaired vibratory sensation (HP:0002495)2.35216984
67Progressive inability to walk (HP:0002505)2.34352445
68Scanning speech (HP:0002168)2.31837214
69Dysmetric saccades (HP:0000641)2.31353289
70Drooling (HP:0002307)2.30653707
71Excessive salivation (HP:0003781)2.30653707
72Spastic tetraparesis (HP:0001285)2.30234968
73Abnormality of the corticospinal tract (HP:0002492)2.28680341
74Aplasia involving bones of the extremities (HP:0009825)2.28057550
75Aplasia involving bones of the upper limbs (HP:0009823)2.28057550
76Clonus (HP:0002169)2.26225199
77Turricephaly (HP:0000262)2.22636626
78Apathy (HP:0000741)2.17437363
79Ankyloglossia (HP:0010296)2.16640387
80Fetal akinesia sequence (HP:0001989)2.14766344
81Limb dystonia (HP:0002451)2.11097597
82Polyphagia (HP:0002591)2.11009413
83Resting tremor (HP:0002322)2.10061727
84Status epilepticus (HP:0002133)2.09433450
85Lower limb amyotrophy (HP:0007210)2.08921823
86Hyperacusis (HP:0010780)2.07628950
87EEG with generalized epileptiform discharges (HP:0011198)2.06448396
88Epileptiform EEG discharges (HP:0011182)2.06059160
89Hypsarrhythmia (HP:0002521)2.04853994
90Hyperventilation (HP:0002883)2.03855949
91Bronchomalacia (HP:0002780)2.00485895
92Spinal canal stenosis (HP:0003416)1.98889413
93Choreoathetosis (HP:0001266)1.98417819
94CNS hypomyelination (HP:0003429)1.98387387
95Morphological abnormality of the pyramidal tract (HP:0002062)1.98065220
96Neuronal loss in central nervous system (HP:0002529)1.97086638
97Agitation (HP:0000713)1.95868990
98Inappropriate behavior (HP:0000719)1.94016389
99Hand muscle atrophy (HP:0009130)1.93791612
100Lower limb asymmetry (HP:0100559)1.90597243
101Diminished motivation (HP:0000745)1.90440177
102Elfin facies (HP:0004428)1.89277380
103Incomplete penetrance (HP:0003829)1.88826828
104Upper limb amyotrophy (HP:0009129)1.88774461
105Distal upper limb amyotrophy (HP:0007149)1.88774461
106Generalized myoclonic seizures (HP:0002123)1.88034431
107Abnormality of saccadic eye movements (HP:0000570)1.87170382
108Abnormal EKG (HP:0003115)1.86093764
109Rapidly progressive (HP:0003678)1.85124945
110Tetraplegia (HP:0002445)1.84629310
111Pheochromocytoma (HP:0002666)1.84621288
112Rigidity (HP:0002063)1.83968411
113Gait ataxia (HP:0002066)1.82924318
114Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.82588243
115Degeneration of the lateral corticospinal tracts (HP:0002314)1.82588243
116Intellectual disability, profound (HP:0002187)1.82101214
117Abnormality of the periventricular white matter (HP:0002518)1.81764940
118Absent speech (HP:0001344)1.81666584
119Overriding aorta (HP:0002623)1.76979488
120Split foot (HP:0001839)1.74107433
121Aplasia of the phalanges of the hand (HP:0009802)1.71134322
122Hammertoe (HP:0001765)1.68698172

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.39747158
2MAP3K94.33437409
3NTRK33.94086430
4MARK13.77646501
5PRKD33.07523770
6DAPK22.92827643
7MINK12.83586457
8PAK62.65194955
9MAP3K42.64326622
10KSR22.37735452
11NTRK22.19922725
12NTRK12.02852074
13MAP2K71.98150105
14STK381.69117926
15CDK51.65311374
16TYRO31.62831172
17MAP2K41.62270669
18KSR11.60519985
19TAOK11.53879595
20DAPK11.51379048
21SIK21.42014333
22RIPK41.37554977
23MAP3K21.34100157
24LATS21.32137470
25UHMK11.27329680
26ALK1.24467858
27PRPF4B1.24232477
28* CAMKK11.21920896
29PHKG21.19923324
30PHKG11.19923324
31GRK51.18975550
32MAPK131.13441509
33CDK191.13434022
34PRKCG1.13394930
35FES1.09514406
36RIPK11.09077811
37TNIK1.08660700
38PLK21.07835657
39MAP3K121.07177723
40PRKCH1.06292930
41PINK11.02288001
42RET0.99182615
43CDK150.99012349
44ARAF0.99010214
45CDK180.97381610
46CAMK10.97271372
47LMTK20.96529667
48MAP3K130.94578325
49CAMKK20.92565002
50CDK140.92028961
51CDK11A0.87178468
52NEK10.84079729
53SGK4940.83761637
54SGK2230.83761637
55MARK20.82136016
56PKN10.81702997
57MAPK120.80877513
58PNCK0.78800385
59SCYL20.77955120
60PAK30.77517704
61RAF10.75224260
62BRAF0.75194175
63SGK30.74684711
64PDK10.74505568
65CAMK2A0.70867218
66LIMK10.70559694
67* STK110.68455053
68MAP3K110.67646427
69PDPK10.67138490
70SGK10.63926045
71CSNK1G20.63253484
72TRIB30.63238395
73ICK0.62428366
74DYRK1A0.60354174
75SGK20.60049174
76PRKCZ0.59598294
77CDC42BPA0.59593654
78MAP3K10.57160339
79TNK20.55761818
80ROCK20.55449097
81RPS6KA30.54785857
82PTK2B0.53280167
83FYN0.51761111
84DDR20.50875306
85CAMK2B0.50661566
86MAP3K70.50293099
87MAPK100.50218230
88DAPK30.49808543
89WNK10.49761381
90CAMK1G0.48570787
91CAMK40.48278630
92NEK60.48004036
93TESK10.45986932
94ERBB20.45138068
95PDGFRA0.45062310
96CAMK1D0.42409012
97DMPK0.41643157
98CAMK2D0.41002635
99DYRK20.39610507
100RPS6KA20.39212177
101OXSR10.39050344
102BMX0.37140076
103ROCK10.36783894
104MAP2K10.35395563
105FGFR20.33442302
106ERBB30.32284412
107MAP2K60.31611660
108MAPK80.30624225
109PRKCB0.30613714
110CAMK2G0.30413227
111EEF2K0.29736138
112CASK0.29698279
113PRKCA0.29165888
114BMPR20.28617206
115PRKG20.28582104
116CSNK1E0.28526015
117GSK3B0.28455797
118SRC0.28127102

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.18958510
2Nicotine addiction_Homo sapiens_hsa050333.07760883
3Olfactory transduction_Homo sapiens_hsa047402.92684177
4Circadian entrainment_Homo sapiens_hsa047132.61528039
5GABAergic synapse_Homo sapiens_hsa047272.57401662
6Long-term potentiation_Homo sapiens_hsa047202.53483505
7Glutamatergic synapse_Homo sapiens_hsa047242.49639244
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.35815447
9Morphine addiction_Homo sapiens_hsa050322.35617891
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.33549617
11Amphetamine addiction_Homo sapiens_hsa050312.30590035
12Dopaminergic synapse_Homo sapiens_hsa047282.10617399
13Salivary secretion_Homo sapiens_hsa049702.09580979
14Insulin secretion_Homo sapiens_hsa049111.97779695
15Gastric acid secretion_Homo sapiens_hsa049711.96739389
16Cholinergic synapse_Homo sapiens_hsa047251.96023414
17Nitrogen metabolism_Homo sapiens_hsa009101.95557150
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.88562860
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.78876273
20Oxytocin signaling pathway_Homo sapiens_hsa049211.65549250
21Cocaine addiction_Homo sapiens_hsa050301.62217641
22Vitamin B6 metabolism_Homo sapiens_hsa007501.57254726
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.55577608
24Renin secretion_Homo sapiens_hsa049241.54537548
25Long-term depression_Homo sapiens_hsa047301.52230525
26GnRH signaling pathway_Homo sapiens_hsa049121.50713335
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48821661
28Calcium signaling pathway_Homo sapiens_hsa040201.43089599
29Gap junction_Homo sapiens_hsa045401.40675745
30Taste transduction_Homo sapiens_hsa047421.39188043
31Glioma_Homo sapiens_hsa052141.33574913
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31589589
33Serotonergic synapse_Homo sapiens_hsa047261.31571467
34Type II diabetes mellitus_Homo sapiens_hsa049301.31311008
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30174101
36cAMP signaling pathway_Homo sapiens_hsa040241.26761423
37Estrogen signaling pathway_Homo sapiens_hsa049151.26176372
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16079407
39Axon guidance_Homo sapiens_hsa043601.13854060
40ErbB signaling pathway_Homo sapiens_hsa040121.12276997
41Melanogenesis_Homo sapiens_hsa049161.07241172
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07214881
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01539448
44Oocyte meiosis_Homo sapiens_hsa041140.99804704
45Dorso-ventral axis formation_Homo sapiens_hsa043200.98983058
46Phospholipase D signaling pathway_Homo sapiens_hsa040720.98159891
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92053523
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.86034324
49Neurotrophin signaling pathway_Homo sapiens_hsa047220.83961627
50Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81479536
51Thyroid hormone synthesis_Homo sapiens_hsa049180.81285513
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80828323
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80520284
54VEGF signaling pathway_Homo sapiens_hsa043700.78938606
55Pancreatic secretion_Homo sapiens_hsa049720.78632976
56Collecting duct acid secretion_Homo sapiens_hsa049660.78099675
57mTOR signaling pathway_Homo sapiens_hsa041500.76078122
58Choline metabolism in cancer_Homo sapiens_hsa052310.75696833
59Dilated cardiomyopathy_Homo sapiens_hsa054140.73730562
60MAPK signaling pathway_Homo sapiens_hsa040100.73334028
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72595778
62Endometrial cancer_Homo sapiens_hsa052130.71604290
63Endocytosis_Homo sapiens_hsa041440.69299510
64Cardiac muscle contraction_Homo sapiens_hsa042600.66321477
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65370309
66Bile secretion_Homo sapiens_hsa049760.64877701
67Rap1 signaling pathway_Homo sapiens_hsa040150.64833168
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64243692
69Non-small cell lung cancer_Homo sapiens_hsa052230.64051463
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.62307623
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62263100
72Glucagon signaling pathway_Homo sapiens_hsa049220.59644770
73Ras signaling pathway_Homo sapiens_hsa040140.58382221
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56653421
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55334497
76Alcoholism_Homo sapiens_hsa050340.54970839
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54552340
78Renal cell carcinoma_Homo sapiens_hsa052110.54013347
79Vibrio cholerae infection_Homo sapiens_hsa051100.53495147
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52337913
81Phototransduction_Homo sapiens_hsa047440.51345702
82Insulin signaling pathway_Homo sapiens_hsa049100.51128436
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49977099
84Inositol phosphate metabolism_Homo sapiens_hsa005620.49791453
85Type I diabetes mellitus_Homo sapiens_hsa049400.49430277
86Prion diseases_Homo sapiens_hsa050200.48702927
87Hippo signaling pathway_Homo sapiens_hsa043900.45265092
88Chemokine signaling pathway_Homo sapiens_hsa040620.44812066
89Wnt signaling pathway_Homo sapiens_hsa043100.44502250
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43437902
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43392766
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41663958
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41231179
94Colorectal cancer_Homo sapiens_hsa052100.41056107
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39843435
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38258625
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.37082602
98Arginine and proline metabolism_Homo sapiens_hsa003300.36144738
99Circadian rhythm_Homo sapiens_hsa047100.35367704
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34764803
101Ovarian steroidogenesis_Homo sapiens_hsa049130.33297854
102Prolactin signaling pathway_Homo sapiens_hsa049170.32967279
103AMPK signaling pathway_Homo sapiens_hsa041520.32892729
104Tight junction_Homo sapiens_hsa045300.32535475
105Platelet activation_Homo sapiens_hsa046110.30782328
106Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30170597
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29656305
108Arginine biosynthesis_Homo sapiens_hsa002200.28248996
109HIF-1 signaling pathway_Homo sapiens_hsa040660.24516691

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