BRSK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.14810944
2synaptic vesicle maturation (GO:0016188)5.91985801
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.58252035
4locomotory exploration behavior (GO:0035641)5.58229967
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.53916118
6vocalization behavior (GO:0071625)5.45114172
7synaptic vesicle exocytosis (GO:0016079)5.32333008
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.27803266
9glutamate secretion (GO:0014047)5.06439516
10regulation of synaptic vesicle exocytosis (GO:2000300)5.01393722
11protein localization to synapse (GO:0035418)4.91217839
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.85288968
13regulation of glutamate receptor signaling pathway (GO:1900449)4.82047571
14neuron cell-cell adhesion (GO:0007158)4.79741385
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.60014887
16layer formation in cerebral cortex (GO:0021819)4.59244030
17neuronal action potential propagation (GO:0019227)4.57650938
18axon ensheathment in central nervous system (GO:0032291)4.48077017
19central nervous system myelination (GO:0022010)4.48077017
20regulation of synaptic vesicle transport (GO:1902803)4.43859890
21neurotransmitter secretion (GO:0007269)4.41085225
22regulation of neuronal synaptic plasticity (GO:0048168)4.39586853
23exploration behavior (GO:0035640)4.39585293
24dendritic spine morphogenesis (GO:0060997)4.30878110
25regulation of long-term neuronal synaptic plasticity (GO:0048169)4.29819670
26synaptic transmission, glutamatergic (GO:0035249)4.21300606
27glutamate receptor signaling pathway (GO:0007215)4.13913318
28regulation of synapse structural plasticity (GO:0051823)4.07356093
29neurotransmitter-gated ion channel clustering (GO:0072578)4.02973836
30gamma-aminobutyric acid transport (GO:0015812)3.96973138
31neuron-neuron synaptic transmission (GO:0007270)3.95337001
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.90246794
33neuron recognition (GO:0008038)3.87153754
34long-term memory (GO:0007616)3.81190894
35positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.79932032
36positive regulation of membrane potential (GO:0045838)3.76621014
37regulation of excitatory postsynaptic membrane potential (GO:0060079)3.76003745
38establishment of mitochondrion localization (GO:0051654)3.73397241
39cellular potassium ion homeostasis (GO:0030007)3.70278077
40regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.70068018
41positive regulation of synapse maturation (GO:0090129)3.69932742
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.66475929
43transmission of nerve impulse (GO:0019226)3.65488422
44proline transport (GO:0015824)3.65466337
45cerebellar Purkinje cell differentiation (GO:0021702)3.65213804
46neurotransmitter transport (GO:0006836)3.64447566
47axonal fasciculation (GO:0007413)3.62746528
48positive regulation of dendritic spine morphogenesis (GO:0061003)3.62092319
49regulation of postsynaptic membrane potential (GO:0060078)3.60214385
50synaptic vesicle endocytosis (GO:0048488)3.59054389
51dendrite morphogenesis (GO:0048813)3.52811093
52regulation of dendritic spine morphogenesis (GO:0061001)3.51217803
53regulation of neurotransmitter secretion (GO:0046928)3.49590270
54pyrimidine nucleobase catabolic process (GO:0006208)3.47932053
55regulation of synaptic plasticity (GO:0048167)3.47114266
56potassium ion homeostasis (GO:0055075)3.46424049
57neuromuscular synaptic transmission (GO:0007274)3.45799209
58neuromuscular process controlling balance (GO:0050885)3.45084201
59auditory behavior (GO:0031223)3.44395297
60postsynaptic membrane organization (GO:0001941)3.43146426
61cell differentiation in hindbrain (GO:0021533)3.41752246
62cell migration in hindbrain (GO:0021535)3.38896081
63sodium ion export (GO:0071436)3.38881648
64regulation of voltage-gated calcium channel activity (GO:1901385)3.36515672
65regulation of neurotransmitter levels (GO:0001505)3.32138088
66activation of protein kinase A activity (GO:0034199)3.31980599
67glycine transport (GO:0015816)3.31686618
68establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.31423109
69mitochondrion transport along microtubule (GO:0047497)3.31423109
70potassium ion import (GO:0010107)3.29619195
71regulation of synaptic transmission, glutamatergic (GO:0051966)3.29443246
72gamma-aminobutyric acid signaling pathway (GO:0007214)3.29435312
73positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.27793973
74amino acid import (GO:0043090)3.27096333
75cerebellar granule cell differentiation (GO:0021707)3.26240532
76G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.25223295
77positive regulation of synaptic transmission, GABAergic (GO:0032230)3.25219496
78long-term synaptic potentiation (GO:0060291)3.24964173
79presynaptic membrane assembly (GO:0097105)3.23793382
80response to auditory stimulus (GO:0010996)3.23467270
81positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.22734036
82neuronal ion channel clustering (GO:0045161)3.22638384
83regulation of vesicle fusion (GO:0031338)3.21866661
84presynaptic membrane organization (GO:0097090)3.21741828
85membrane hyperpolarization (GO:0060081)3.21634410
86regulation of neurotransmitter transport (GO:0051588)3.21419770
87membrane depolarization during action potential (GO:0086010)3.20405864
88regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.18464846
89membrane depolarization (GO:0051899)3.17704721
90neuromuscular process controlling posture (GO:0050884)3.17650925
91mechanosensory behavior (GO:0007638)3.17435834
92prepulse inhibition (GO:0060134)3.16026176
93negative regulation of synaptic transmission, GABAergic (GO:0032229)3.16012120
94positive regulation of neurotransmitter secretion (GO:0001956)3.15160438
95L-amino acid import (GO:0043092)3.12379944
96synapse assembly (GO:0007416)3.09894326
97adult walking behavior (GO:0007628)3.09846150
98positive regulation of neurotransmitter transport (GO:0051590)3.08841941
99learning (GO:0007612)3.05486644
100innervation (GO:0060384)3.05419851
101cerebellar Purkinje cell layer development (GO:0021680)3.04710735
102dendritic spine organization (GO:0097061)3.04079729
103positive regulation of synapse assembly (GO:0051965)3.03251697
104central nervous system projection neuron axonogenesis (GO:0021952)3.02071419
105cell communication by electrical coupling (GO:0010644)2.99784717
106cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.99531794
107cellular sodium ion homeostasis (GO:0006883)2.99210112
108regulation of ARF protein signal transduction (GO:0032012)2.98683477
109positive regulation of dendritic spine development (GO:0060999)2.98382884
110negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.97010116
111regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.96852880
112mating behavior (GO:0007617)2.95638118
113intraspecies interaction between organisms (GO:0051703)2.95347597
114social behavior (GO:0035176)2.95347597
115regulation of dendritic spine development (GO:0060998)2.95265744
116behavioral response to nicotine (GO:0035095)2.94566932
117regulation of synaptic transmission (GO:0050804)2.94495419
118neuromuscular process (GO:0050905)2.93586570
119vesicle transport along microtubule (GO:0047496)2.92927735
120regulation of synapse maturation (GO:0090128)2.92703401

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.11901196
2GBX2_23144817_ChIP-Seq_PC3_Human3.34482269
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.04251980
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.03143808
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.98512585
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.80272053
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70916641
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70916641
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62181078
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.55945839
11DROSHA_22980978_ChIP-Seq_HELA_Human2.54554937
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.54015031
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49341509
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49200564
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.48142803
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46191933
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39052764
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.34495901
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.32186158
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.25914683
21* REST_18959480_ChIP-ChIP_MESCs_Mouse2.25634114
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.23487823
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.22627122
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.07240701
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06323973
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.97330146
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96204098
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93092473
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.91086928
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.88462977
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.86933475
32AR_21572438_ChIP-Seq_LNCaP_Human1.76972310
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72995662
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60563254
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.58836974
36SMAD4_21799915_ChIP-Seq_A2780_Human1.54637739
37TAF15_26573619_Chip-Seq_HEK293_Human1.54025531
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53934620
39ZFP281_27345836_Chip-Seq_ESCs_Mouse1.50440333
40ZNF274_21170338_ChIP-Seq_K562_Hela1.45467121
41* CTCF_27219007_Chip-Seq_Bcells_Human1.43941739
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40865600
43RING1B_27294783_Chip-Seq_ESCs_Mouse1.37984056
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.36755883
45GATA1_26923725_Chip-Seq_HPCs_Mouse1.36409489
46RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.35855712
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34810788
48* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.34650799
49TP53_20018659_ChIP-ChIP_R1E_Mouse1.34572273
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32302975
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30305152
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30007951
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.26991280
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.25106215
55P300_19829295_ChIP-Seq_ESCs_Human1.24933253
56SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.23427543
57AR_19668381_ChIP-Seq_PC3_Human1.22237523
58RING1B_27294783_Chip-Seq_NPCs_Mouse1.19999445
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19741113
60RNF2_27304074_Chip-Seq_NSC_Mouse1.19075897
61* STAT3_23295773_ChIP-Seq_U87_Human1.18888230
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17084105
63AR_25329375_ChIP-Seq_VCAP_Human1.16068448
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15574269
65WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15279289
66KDM2B_26808549_Chip-Seq_K562_Human1.14194979
67EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13907743
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13566751
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13536372
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13218242
71P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12289890
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12097679
73ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11910435
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08878054
75* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08188784
76IGF1R_20145208_ChIP-Seq_DFB_Human1.07633719
77TCF4_23295773_ChIP-Seq_U87_Human1.06483044
78MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06069392
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05257371
80ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03830785
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.03614495
82YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02695915
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.02334124
84* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01236207
85WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01069069
86AHR_22903824_ChIP-Seq_MCF-7_Human1.00630002
87ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00627370
88RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99391539
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99264980
90SMAD_19615063_ChIP-ChIP_OVARY_Human0.98192739
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98192226
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98192226
93SMAD3_21741376_ChIP-Seq_ESCs_Human0.97170075
94CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95853224
95SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94673505
96* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93837560
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93738175
98OCT4_19829295_ChIP-Seq_ESCs_Human0.93695903
99RUNX2_22187159_ChIP-Seq_PCA_Human0.93648911
100NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92078142
101PRDM14_20953172_ChIP-Seq_ESCs_Human0.91623483
102* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91262429
103SMAD4_21741376_ChIP-Seq_HESCs_Human0.91095300
104TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90902035
105POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89944971
106LXR_22292898_ChIP-Seq_THP-1_Human0.89448837
107CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88028460
108OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86882131
109TET1_21490601_ChIP-Seq_MESCs_Mouse0.86124712
110KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85520745
111GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85419138
112VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.85341313
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85106859
114DPY_21335234_ChIP-Seq_ESCs_Mouse0.85089049
115UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84567757
116SMAD3_21741376_ChIP-Seq_HESCs_Human0.84081095
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83785604
118SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81294661
119RUNX1_26923725_Chip-Seq_HPCs_Mouse0.80518683
120SRY_22984422_ChIP-ChIP_TESTIS_Rat0.80263380
121SMC4_20622854_ChIP-Seq_HELA_Human0.77892059
122* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.76869702
123* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76611069
124NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.76479002
125* KLF4_19829295_ChIP-Seq_ESCs_Human0.75742789
126* CREB1_26743006_Chip-Seq_LNCaP_Human0.74492437
127ISL1_27105846_Chip-Seq_CPCs_Mouse0.73352948
128SOX3_22085726_ChIP-Seq_NPCs_Mouse0.72620110
129* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.71734201
130SMAD4_21741376_ChIP-Seq_ESCs_Human0.71570661
131SOX9_26525672_Chip-Seq_HEART_Mouse0.70843885
132POU5F1_16518401_ChIP-PET_MESCs_Mouse0.69756470
133* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.69435718
134P68_20966046_ChIP-Seq_HELA_Human0.69063298

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.31412287
2MP0003880_abnormal_central_pattern4.85629542
3MP0003635_abnormal_synaptic_transmissio4.07292451
4MP0004270_analgesia3.84945880
5MP0009745_abnormal_behavioral_response3.28057726
6MP0002063_abnormal_learning/memory/cond3.25471642
7MP0005423_abnormal_somatic_nervous3.21448923
8MP0009046_muscle_twitch3.16868474
9MP0002064_seizures3.10750285
10MP0001968_abnormal_touch/_nociception2.92501399
11MP0002734_abnormal_mechanical_nocicepti2.77559795
12MP0002572_abnormal_emotion/affect_behav2.73721883
13MP0001486_abnormal_startle_reflex2.72028302
14MP0002272_abnormal_nervous_system2.63884300
15MP0002822_catalepsy2.32347770
16MP0002736_abnormal_nociception_after2.20028629
17MP0002735_abnormal_chemical_nociception2.17021819
18MP0000778_abnormal_nervous_system2.15677230
19MP0001440_abnormal_grooming_behavior2.09231644
20MP0001501_abnormal_sleep_pattern2.05603625
21MP0002067_abnormal_sensory_capabilities2.04000179
22MP0002733_abnormal_thermal_nociception2.02593274
23MP0008569_lethality_at_weaning2.00969548
24MP0002184_abnormal_innervation1.96373240
25MP0001970_abnormal_pain_threshold1.95792617
26MP0003123_paternal_imprinting1.87605564
27MP0004811_abnormal_neuron_physiology1.84805276
28MP0009780_abnormal_chondrocyte_physiolo1.82873598
29MP0002557_abnormal_social/conspecific_i1.80490875
30MP0003329_amyloid_beta_deposits1.78449618
31MP0004858_abnormal_nervous_system1.75500017
32MP0004924_abnormal_behavior1.74107392
33MP0005386_behavior/neurological_phenoty1.74107392
34MP0006276_abnormal_autonomic_nervous1.73861112
35MP0000955_abnormal_spinal_cord1.72130335
36MP0004885_abnormal_endolymph1.70091100
37MP0001984_abnormal_olfaction1.68089498
38MP0002882_abnormal_neuron_morphology1.59396617
39MP0002909_abnormal_adrenal_gland1.59102911
40MP0005646_abnormal_pituitary_gland1.56260518
41MP0002066_abnormal_motor_capabilities/c1.47682777
42MP0003787_abnormal_imprinting1.47468152
43MP0003879_abnormal_hair_cell1.42729345
44MP0004142_abnormal_muscle_tone1.36934708
45MP0003633_abnormal_nervous_system1.31404557
46MP0005551_abnormal_eye_electrophysiolog1.31336539
47MP0001529_abnormal_vocalization1.30877221
48MP0005645_abnormal_hypothalamus_physiol1.30837234
49MP0001502_abnormal_circadian_rhythm1.30804600
50MP0000566_synostosis1.28657649
51MP0003121_genomic_imprinting1.25318888
52MP0001905_abnormal_dopamine_level1.24668541
53MP0002152_abnormal_brain_morphology1.24010691
54MP0000569_abnormal_digit_pigmentation1.22165053
55MP0004742_abnormal_vestibular_system1.19743494
56MP0003631_nervous_system_phenotype1.17037860
57MP0002229_neurodegeneration1.16395987
58MP0003122_maternal_imprinting1.07508159
59MP0000920_abnormal_myelination1.04319503
60MP0005394_taste/olfaction_phenotype1.03171844
61MP0005499_abnormal_olfactory_system1.03171844
62MP0009379_abnormal_foot_pigmentation1.01688524
63MP0001346_abnormal_lacrimal_gland1.01214282
64MP0003634_abnormal_glial_cell1.00718414
65MP0004145_abnormal_muscle_electrophysio0.99638394
66MP0002752_abnormal_somatic_nervous0.97059990
67MP0003632_abnormal_nervous_system0.95010301
68MP0002069_abnormal_eating/drinking_beha0.93592548
69MP0001177_atelectasis0.93019712
70MP0001188_hyperpigmentation0.92218090
71MP0000751_myopathy0.90963829
72MP0003690_abnormal_glial_cell0.90510403
73MP0003938_abnormal_ear_development0.90446506
74MP0001963_abnormal_hearing_physiology0.90337602
75MP0000631_abnormal_neuroendocrine_gland0.90071190
76MP0002249_abnormal_larynx_morphology0.89430761
77MP0008877_abnormal_DNA_methylation0.88557182
78MP0006292_abnormal_olfactory_placode0.85641745
79MP0008872_abnormal_physiological_respon0.85578375
80MP0004133_heterotaxia0.83873955
81MP0006072_abnormal_retinal_apoptosis0.83759305
82MP0001485_abnormal_pinna_reflex0.83669518
83MP0003283_abnormal_digestive_organ0.81679697
84MP0010386_abnormal_urinary_bladder0.77977961
85MP0004085_abnormal_heartbeat0.76589864
86MP0003861_abnormal_nervous_system0.76301929
87MP0002638_abnormal_pupillary_reflex0.74585983
88MP0008961_abnormal_basal_metabolism0.73289890
89MP0008874_decreased_physiological_sensi0.73147117
90MP0002090_abnormal_vision0.72256626
91MP0001348_abnormal_lacrimal_gland0.71546972
92MP0002653_abnormal_ependyma_morphology0.71082369
93MP0000579_abnormal_nail_morphology0.70960825
94MP0005535_abnormal_body_temperature0.70288369
95MP0000604_amyloidosis0.69076572
96MP0005253_abnormal_eye_physiology0.68641430
97MP0003136_yellow_coat_color0.68589442
98MP0003137_abnormal_impulse_conducting0.68423876
99MP0003119_abnormal_digestive_system0.66605881
100MP0001299_abnormal_eye_distance/0.66516488
101MP0001986_abnormal_taste_sensitivity0.65303408
102MP0000013_abnormal_adipose_tissue0.65207182
103MP0002081_perinatal_lethality0.64437812
104MP0005409_darkened_coat_color0.63196618
105MP0005623_abnormal_meninges_morphology0.61912801
106MP0004130_abnormal_muscle_cell0.60909156
107MP0000026_abnormal_inner_ear0.59556330
108MP0004233_abnormal_muscle_weight0.59351064
109MP0010769_abnormal_survival0.59293238
110MP0001943_abnormal_respiration0.59080935
111MP0003075_altered_response_to0.58532785
112MP0010770_preweaning_lethality0.57363841
113MP0002082_postnatal_lethality0.57363841
114MP0005187_abnormal_penis_morphology0.57243895
115MP0000537_abnormal_urethra_morphology0.56291076
116MP0010768_mortality/aging0.55937612
117MP0005410_abnormal_fertilization0.55603385
118MP0004215_abnormal_myocardial_fiber0.53102957

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.90372143
2Myokymia (HP:0002411)6.74535833
3Focal seizures (HP:0007359)5.51367398
4Visual hallucinations (HP:0002367)5.02276632
5Epileptic encephalopathy (HP:0200134)4.60203722
6Progressive cerebellar ataxia (HP:0002073)4.40493172
7Atonic seizures (HP:0010819)4.27559560
8Action tremor (HP:0002345)4.23022586
9Febrile seizures (HP:0002373)4.17447066
10Supranuclear gaze palsy (HP:0000605)3.81758504
11Absence seizures (HP:0002121)3.80352531
12Broad-based gait (HP:0002136)3.63221777
13Ankle clonus (HP:0011448)3.63144611
14Generalized tonic-clonic seizures (HP:0002069)3.56223756
15Dialeptic seizures (HP:0011146)3.52637740
16Gaze-evoked nystagmus (HP:0000640)3.42572291
17Poor eye contact (HP:0000817)3.25802153
18Impaired vibration sensation in the lower limbs (HP:0002166)3.22766873
19Dysdiadochokinesis (HP:0002075)3.21950975
20Urinary bladder sphincter dysfunction (HP:0002839)3.15861760
21Mutism (HP:0002300)3.08219193
22Depression (HP:0000716)3.08054219
23Dysmetria (HP:0001310)3.07006435
24Truncal ataxia (HP:0002078)3.05081701
25Abnormal social behavior (HP:0012433)2.94129596
26Impaired social interactions (HP:0000735)2.94129596
27Hyperventilation (HP:0002883)2.89871496
28Genetic anticipation (HP:0003743)2.86807095
29Spastic gait (HP:0002064)2.86128668
30Amblyopia (HP:0000646)2.85285685
31Anxiety (HP:0000739)2.83784990
32Abnormality of the corticospinal tract (HP:0002492)2.81419017
33Abnormal eating behavior (HP:0100738)2.79907450
34Urinary urgency (HP:0000012)2.79102802
35Insidious onset (HP:0003587)2.75940472
36Termporal pattern (HP:0011008)2.75940472
37Abnormality of the lower motor neuron (HP:0002366)2.75783073
38Hemiparesis (HP:0001269)2.75272846
39Sleep apnea (HP:0010535)2.74509736
40Postural instability (HP:0002172)2.73587376
41Impaired smooth pursuit (HP:0007772)2.72136245
42Cerebral hypomyelination (HP:0006808)2.70779193
43Drooling (HP:0002307)2.70695202
44Excessive salivation (HP:0003781)2.70695202
45Intention tremor (HP:0002080)2.67996819
46Papilledema (HP:0001085)2.63691194
47Neurofibrillary tangles (HP:0002185)2.62510364
48Scanning speech (HP:0002168)2.60907824
49Megalencephaly (HP:0001355)2.50453391
50Cerebral inclusion bodies (HP:0100314)2.50189493
51Torticollis (HP:0000473)2.45050010
52Limb dystonia (HP:0002451)2.44655337
53Progressive inability to walk (HP:0002505)2.44250796
54Abnormality of ocular smooth pursuit (HP:0000617)2.42108711
55Epileptiform EEG discharges (HP:0011182)2.39857848
56Akinesia (HP:0002304)2.38762762
57Abnormality of binocular vision (HP:0011514)2.37018466
58Diplopia (HP:0000651)2.37018466
59Stereotypic behavior (HP:0000733)2.35771851
60Hemiplegia (HP:0002301)2.34992749
61EEG with generalized epileptiform discharges (HP:0011198)2.34513915
62Focal dystonia (HP:0004373)2.28281602
63Lower limb muscle weakness (HP:0007340)2.26342908
64Bradykinesia (HP:0002067)2.25538112
65Hypsarrhythmia (HP:0002521)2.25399343
66Absent speech (HP:0001344)2.23957556
67Fetal akinesia sequence (HP:0001989)2.23101591
68Pheochromocytoma (HP:0002666)2.22745217
69Amyotrophic lateral sclerosis (HP:0007354)2.20989185
70Ventricular fibrillation (HP:0001663)2.20838745
71Insomnia (HP:0100785)2.19244377
72Impaired vibratory sensation (HP:0002495)2.15228027
73Agitation (HP:0000713)2.13396377
74Spastic tetraparesis (HP:0001285)2.13146715
75Aplasia involving bones of the upper limbs (HP:0009823)2.10607438
76Aplasia of the phalanges of the hand (HP:0009802)2.10607438
77Aplasia involving bones of the extremities (HP:0009825)2.10607438
78Tetraplegia (HP:0002445)2.08231298
79Degeneration of the lateral corticospinal tracts (HP:0002314)2.07206809
80Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.07206809
81Dysmetric saccades (HP:0000641)2.06808436
82Turricephaly (HP:0000262)2.05727303
83Polyphagia (HP:0002591)2.03725074
84Craniofacial dystonia (HP:0012179)2.00916563
85Clonus (HP:0002169)2.00040020
86Status epilepticus (HP:0002133)1.96316243
87Gait ataxia (HP:0002066)1.96198873
88Generalized myoclonic seizures (HP:0002123)1.96074928
89Pointed chin (HP:0000307)1.93539814
90Annular pancreas (HP:0001734)1.91954282
91Specific learning disability (HP:0001328)1.90493458
92Inability to walk (HP:0002540)1.89369600
93Neuronal loss in central nervous system (HP:0002529)1.89364742
94Incomplete penetrance (HP:0003829)1.88626466
95Abnormality of saccadic eye movements (HP:0000570)1.87019298
96Hypoplasia of the brainstem (HP:0002365)1.84981468
97Aplasia/Hypoplasia of the brainstem (HP:0007362)1.84981468
98CNS hypomyelination (HP:0003429)1.84168274
99Bronchomalacia (HP:0002780)1.83830117
100Inappropriate behavior (HP:0000719)1.83732659
101Central scotoma (HP:0000603)1.83067678
102Neuroendocrine neoplasm (HP:0100634)1.81769534
103Gait imbalance (HP:0002141)1.81335832
104Spastic tetraplegia (HP:0002510)1.80708331
105Obstructive sleep apnea (HP:0002870)1.80537263
106Abnormality of salivation (HP:0100755)1.79917618
107Apathy (HP:0000741)1.79454981
108Hypoplasia of the corpus callosum (HP:0002079)1.78293547
109Peripheral hypomyelination (HP:0007182)1.76954332
110Morphological abnormality of the pyramidal tract (HP:0002062)1.76516656
111Overriding aorta (HP:0002623)1.75926515
112Blue irides (HP:0000635)1.75772541
113Delusions (HP:0000746)1.75573116
114Aqueductal stenosis (HP:0002410)1.75177026
115Abnormality of the labia minora (HP:0012880)1.74669883
116Choreoathetosis (HP:0001266)1.74334117
117Hepatoblastoma (HP:0002884)1.73084023
118Split foot (HP:0001839)1.72503515
119Hyperacusis (HP:0010780)1.66315940
120Elfin facies (HP:0004428)1.64045151
121Abnormality of the aortic arch (HP:0012303)1.62083025
122Retinal dysplasia (HP:0007973)1.61665901

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.04427455
2EPHA43.83312492
3MARK13.74614305
4MAP3K93.68247217
5MAP3K43.00419035
6MINK12.74186759
7DAPK22.56514785
8MAP2K72.48578038
9PAK62.43135710
10NTRK22.28065939
11PRKD32.21036817
12CASK1.84483166
13KSR21.82512484
14CAMKK11.82345144
15NTRK11.78540483
16MAP2K41.77841968
17TNIK1.71416528
18PNCK1.67316909
19MAPK131.64169105
20KSR11.63226962
21MAP3K121.60118563
22CDK51.60079399
23SIK21.57294822
24RIPK41.49426704
25PRPF4B1.47232558
26CDK191.45400860
27UHMK11.45260271
28TYRO31.38986482
29PLK21.35495370
30STK381.33043059
31GRK51.31717519
32DAPK11.29142224
33PHKG21.18240628
34PHKG11.18240628
35PRKCG1.16431081
36SGK4941.09083394
37SGK2231.09083394
38FES1.02549353
39MAP3K21.01143439
40CAMK1D1.00620141
41OXSR10.99797420
42CAMKK20.98494726
43CDK180.98189216
44CDK150.96665770
45CAMK2A0.92909681
46CDK140.91824669
47ARAF0.90840020
48LATS20.88818977
49PRKCH0.86752911
50CSNK1G20.85920406
51CAMK10.84791247
52CDK11A0.84526283
53DYRK1A0.83893311
54MARK20.81027853
55RET0.80356748
56TAOK10.79896213
57PINK10.78358908
58CAMK2B0.77626090
59SGK20.76808851
60PAK30.76193141
61BRSK10.76049187
62MAP3K130.69423687
63WNK10.66618712
64ALK0.66157357
65* STK110.65070057
66SGK30.65007275
67MAP3K110.64884574
68SGK10.64391869
69CAMK1G0.64224468
70TNK20.63312639
71LMTK20.60504772
72PTK2B0.60225104
73EPHB20.57994201
74MAPK120.57863791
75BMPR20.57276490
76ICK0.56621174
77PRKCZ0.55001751
78STK390.54652706
79MAPK150.53818455
80PDK10.53756405
81RAF10.53196817
82NEK60.52969900
83DYRK1B0.52876258
84PDPK10.52679395
85PKN10.52580453
86FGFR20.52206494
87CDC42BPA0.52046435
88BCR0.51777967
89BRAF0.51542550
90ERBB20.50559146
91RPS6KA30.50036243
92MAPK100.47614367
93FYN0.46604588
94RPS6KA20.45843133
95DAPK30.45459298
96CAMK40.45431847
97ERBB30.44638090
98CAMK2D0.44493247
99CSNK1E0.44316545
100RIPK10.44072383
101PRKCE0.43532214
102FGR0.43407090
103CAMK2G0.42232149
104WNK30.41397754
105ROCK20.40958899
106MAPK80.40136522
107CSNK1G30.37977476
108CCNB10.37108442
109MAP3K10.37106496
110GSK3B0.35379465
111DYRK20.34493099
112LIMK10.34341728
113CSNK1D0.33791876
114PRKCB0.33047479
115WNK40.32872834
116MAPKAPK50.32244942
117PRKAA10.30773914
118PRKDC0.29044540
119PRKG10.28952469
120* PRKACA0.28158060
121PRKCA0.27014964
122TRIB30.25534148

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.62904023
2Synaptic vesicle cycle_Homo sapiens_hsa047213.31776929
3Olfactory transduction_Homo sapiens_hsa047402.75078114
4GABAergic synapse_Homo sapiens_hsa047272.70529662
5Circadian entrainment_Homo sapiens_hsa047132.66250189
6Glutamatergic synapse_Homo sapiens_hsa047242.65872598
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.63773902
8Long-term potentiation_Homo sapiens_hsa047202.58524895
9Morphine addiction_Homo sapiens_hsa050322.46600006
10Amphetamine addiction_Homo sapiens_hsa050312.35767678
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.21505336
12Dopaminergic synapse_Homo sapiens_hsa047282.20322001
13Salivary secretion_Homo sapiens_hsa049702.08732341
14Insulin secretion_Homo sapiens_hsa049112.01646722
15Cholinergic synapse_Homo sapiens_hsa047251.94108088
16Gastric acid secretion_Homo sapiens_hsa049711.86951401
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79626314
18Taste transduction_Homo sapiens_hsa047421.79357342
19Long-term depression_Homo sapiens_hsa047301.74490234
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68975702
21Serotonergic synapse_Homo sapiens_hsa047261.64729170
22Cocaine addiction_Homo sapiens_hsa050301.64506502
23Oxytocin signaling pathway_Homo sapiens_hsa049211.61535683
24Renin secretion_Homo sapiens_hsa049241.60589781
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.55754857
26Calcium signaling pathway_Homo sapiens_hsa040201.49159415
27GnRH signaling pathway_Homo sapiens_hsa049121.44289367
28Phototransduction_Homo sapiens_hsa047441.42271404
29Gap junction_Homo sapiens_hsa045401.38994825
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37068201
31Axon guidance_Homo sapiens_hsa043601.36188284
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33004476
33Collecting duct acid secretion_Homo sapiens_hsa049661.27940436
34cAMP signaling pathway_Homo sapiens_hsa040241.24512822
35Type II diabetes mellitus_Homo sapiens_hsa049301.23373639
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19826589
37Estrogen signaling pathway_Homo sapiens_hsa049151.16461173
38Glioma_Homo sapiens_hsa052141.15365123
39Vitamin B6 metabolism_Homo sapiens_hsa007501.11962430
40ErbB signaling pathway_Homo sapiens_hsa040121.11512969
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09151218
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06652734
43Melanogenesis_Homo sapiens_hsa049161.02391132
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00384041
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97555285
46Cardiac muscle contraction_Homo sapiens_hsa042600.96713369
47Nitrogen metabolism_Homo sapiens_hsa009100.96275400
48Pancreatic secretion_Homo sapiens_hsa049720.92266013
49Oocyte meiosis_Homo sapiens_hsa041140.91229374
50Dorso-ventral axis formation_Homo sapiens_hsa043200.89614534
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.89142820
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.88668901
53Vibrio cholerae infection_Homo sapiens_hsa051100.82491530
54Choline metabolism in cancer_Homo sapiens_hsa052310.76203350
55MAPK signaling pathway_Homo sapiens_hsa040100.74322028
56Thyroid hormone synthesis_Homo sapiens_hsa049180.72945184
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71991430
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71911772
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70092608
60Hippo signaling pathway_Homo sapiens_hsa043900.68509641
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67897498
62VEGF signaling pathway_Homo sapiens_hsa043700.65601479
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.65303477
64Dilated cardiomyopathy_Homo sapiens_hsa054140.64811091
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62065976
66Notch signaling pathway_Homo sapiens_hsa043300.61747289
67Ras signaling pathway_Homo sapiens_hsa040140.61703783
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61637758
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60942823
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.60203597
71Alcoholism_Homo sapiens_hsa050340.58628496
72Endometrial cancer_Homo sapiens_hsa052130.58252331
73Basal cell carcinoma_Homo sapiens_hsa052170.57982727
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56948522
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56839590
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56142202
77Hedgehog signaling pathway_Homo sapiens_hsa043400.55083993
78Renal cell carcinoma_Homo sapiens_hsa052110.54580597
79Inositol phosphate metabolism_Homo sapiens_hsa005620.54435382
80mTOR signaling pathway_Homo sapiens_hsa041500.54375667
81Endocytosis_Homo sapiens_hsa041440.54173314
82Rap1 signaling pathway_Homo sapiens_hsa040150.52990889
83Oxidative phosphorylation_Homo sapiens_hsa001900.52502575
84Circadian rhythm_Homo sapiens_hsa047100.51132867
85Glucagon signaling pathway_Homo sapiens_hsa049220.50417974
86Parkinsons disease_Homo sapiens_hsa050120.49270882
87Wnt signaling pathway_Homo sapiens_hsa043100.49254288
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45328268
89Non-small cell lung cancer_Homo sapiens_hsa052230.45137236
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44445656
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43230433
92Fatty acid biosynthesis_Homo sapiens_hsa000610.43079215
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41435056
94Type I diabetes mellitus_Homo sapiens_hsa049400.40468149
95Bile secretion_Homo sapiens_hsa049760.40335212
96Tight junction_Homo sapiens_hsa045300.40297049
97Insulin signaling pathway_Homo sapiens_hsa049100.39163666
98Arginine and proline metabolism_Homo sapiens_hsa003300.37854753
99Ovarian steroidogenesis_Homo sapiens_hsa049130.37533749
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36364284
101Prion diseases_Homo sapiens_hsa050200.34875704
102Colorectal cancer_Homo sapiens_hsa052100.34545426
103AMPK signaling pathway_Homo sapiens_hsa041520.34505865
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33841682
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32932568
106Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32116195
107Chemokine signaling pathway_Homo sapiens_hsa040620.31919728
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30373726
109Huntingtons disease_Homo sapiens_hsa050160.29954588
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28984666
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.28867974
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28538115
113Alzheimers disease_Homo sapiens_hsa050100.27817460
114Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.27441261

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