BRWD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cornea development in camera-type eye (GO:0061303)5.19355067
2synapsis (GO:0007129)4.32152069
3regulation of timing of cell differentiation (GO:0048505)4.25990221
4nuclear pore complex assembly (GO:0051292)4.08473510
5regulation of development, heterochronic (GO:0040034)4.08288154
6histone H3-K4 trimethylation (GO:0080182)3.96475894
7hindbrain development (GO:0030902)3.79094041
8establishment of protein localization to Golgi (GO:0072600)3.76723151
9pyrimidine nucleobase catabolic process (GO:0006208)3.76061492
10neural tube formation (GO:0001841)3.73763392
11microtubule anchoring (GO:0034453)3.71290919
12histone H3-K36 demethylation (GO:0070544)3.63768601
13histone H3-K4 methylation (GO:0051568)3.53017672
14nuclear pore organization (GO:0006999)3.52657179
15mitotic sister chromatid cohesion (GO:0007064)3.49642300
16negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.35289025
17negative regulation of translation, ncRNA-mediated (GO:0040033)3.35289025
18regulation of translation, ncRNA-mediated (GO:0045974)3.35289025
19presynaptic membrane assembly (GO:0097105)3.32808762
20histone H3-K9 methylation (GO:0051567)3.31718664
21peptidyl-lysine trimethylation (GO:0018023)3.24937185
22resolution of meiotic recombination intermediates (GO:0000712)3.20784806
23retrograde transport, vesicle recycling within Golgi (GO:0000301)3.17709351
24pre-miRNA processing (GO:0031054)3.16774893
25histone lysine demethylation (GO:0070076)3.09062622
26cytoplasmic mRNA processing body assembly (GO:0033962)3.08176378
27nucleobase catabolic process (GO:0046113)3.07808647
28keratinocyte development (GO:0003334)3.05743177
29male meiosis I (GO:0007141)3.02632532
30presynaptic membrane organization (GO:0097090)3.02564218
31gastrulation with mouth forming second (GO:0001702)3.02551161
32histone demethylation (GO:0016577)3.02194665
33limb bud formation (GO:0060174)3.02041409
34DNA methylation involved in gamete generation (GO:0043046)3.01409854
35histone lysine methylation (GO:0034968)3.01215908
36protein K11-linked deubiquitination (GO:0035871)3.01012638
37cerebellar Purkinje cell differentiation (GO:0021702)2.95030616
38pore complex assembly (GO:0046931)2.94851128
39prostate gland growth (GO:0060736)2.93249910
40monoubiquitinated protein deubiquitination (GO:0035520)2.92552522
41regulation of RNA export from nucleus (GO:0046831)2.91402301
42chromosome organization involved in meiosis (GO:0070192)2.88725289
43reciprocal DNA recombination (GO:0035825)2.87291377
44reciprocal meiotic recombination (GO:0007131)2.87291377
45establishment of nucleus localization (GO:0040023)2.87258599
46Golgi to endosome transport (GO:0006895)2.82914485
47histone H3-K9 demethylation (GO:0033169)2.82879257
48embryonic camera-type eye morphogenesis (GO:0048596)2.79677203
49gamma-aminobutyric acid transport (GO:0015812)2.77755079
50male meiosis (GO:0007140)2.76640639
51embryonic foregut morphogenesis (GO:0048617)2.76293115
52histone H3-K9 modification (GO:0061647)2.74735386
53protein localization to Golgi apparatus (GO:0034067)2.72818279
54protein demethylation (GO:0006482)2.71973599
55protein dealkylation (GO:0008214)2.71973599
56stress granule assembly (GO:0034063)2.70507996
57photoreceptor cell development (GO:0042461)2.69649858
58insulin-like growth factor receptor signaling pathway (GO:0048009)2.69472379
59genitalia morphogenesis (GO:0035112)2.68457282
60nucleus localization (GO:0051647)2.68385406
61histone H2A acetylation (GO:0043968)2.67371204
62response to pheromone (GO:0019236)2.63473332
63negative regulation of histone methylation (GO:0031061)2.63259628
64eye photoreceptor cell development (GO:0042462)2.62848535
65negative regulation of dendrite development (GO:2000171)2.62070089
66regulation of sarcomere organization (GO:0060297)2.61201508
67paraxial mesoderm development (GO:0048339)2.61091068
68negative regulation of cytosolic calcium ion concentration (GO:0051481)2.58345390
69mRNA splice site selection (GO:0006376)2.53530588
70cerebral cortex radially oriented cell migration (GO:0021799)2.52719387
71regulation of nucleobase-containing compound transport (GO:0032239)2.51471276
72positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.51463712
73sister chromatid cohesion (GO:0007062)2.51097483
74regulation of meiosis I (GO:0060631)2.51085456
75positive regulation of dendritic spine morphogenesis (GO:0061003)2.50304463
76histone methylation (GO:0016571)2.49818624
77gene silencing by RNA (GO:0031047)2.49100002
78histone H4-K5 acetylation (GO:0043981)2.48381015
79histone H4-K8 acetylation (GO:0043982)2.48381015
80positive regulation of cell fate commitment (GO:0010455)2.48289549
81protein prenylation (GO:0018342)2.47375147
82prenylation (GO:0097354)2.47375147
83astrocyte differentiation (GO:0048708)2.46928343
84regulation of protein polyubiquitination (GO:1902914)2.46855256
85positive regulation of neuroblast proliferation (GO:0002052)2.46627123
86central nervous system projection neuron axonogenesis (GO:0021952)2.45952735
87histone H4-K12 acetylation (GO:0043983)2.45943887
88otic vesicle formation (GO:0030916)2.45768283
89regulation of short-term neuronal synaptic plasticity (GO:0048172)2.45679665
90artery development (GO:0060840)2.45326050
91sympathetic nervous system development (GO:0048485)2.45231782
92male sex determination (GO:0030238)2.43122850
93oocyte development (GO:0048599)2.42609581
94cilium morphogenesis (GO:0060271)2.41830316
95regulation of DNA endoreduplication (GO:0032875)2.41466306
96histone H4-K16 acetylation (GO:0043984)2.41176333
97olfactory bulb development (GO:0021772)2.39164835
98dosage compensation (GO:0007549)2.38634829
99regulation of pigment cell differentiation (GO:0050932)2.38348194
100membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.37653777
101DNA double-strand break processing (GO:0000729)2.37060669
102intraciliary transport (GO:0042073)2.36404422
103replication fork processing (GO:0031297)2.33844921
104centriole replication (GO:0007099)2.32336905
105regulation of establishment of cell polarity (GO:2000114)2.31347499
106peptidyl-lysine methylation (GO:0018022)2.31142177
107interkinetic nuclear migration (GO:0022027)2.30929898
108retinal cone cell development (GO:0046549)2.30910801
109pancreas development (GO:0031016)2.30577859
110regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.29698706
111positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.29698706
112microtubule nucleation (GO:0007020)2.29557607
113axonal fasciculation (GO:0007413)2.28802163
114replicative senescence (GO:0090399)2.27412617
115microtubule depolymerization (GO:0007019)2.26872461
116negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.26750171
117limb development (GO:0060173)2.25922037
118appendage development (GO:0048736)2.25922037
119histone H2A monoubiquitination (GO:0035518)2.23068480
120heart morphogenesis (GO:0003007)2.22781239
121layer formation in cerebral cortex (GO:0021819)2.22698294
122regulation of telomere maintenance (GO:0032204)2.20335743
123phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.17938036
124anatomical structure arrangement (GO:0048532)2.17321384
125regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.16289288
126DNA methylation (GO:0006306)2.15311732
127DNA alkylation (GO:0006305)2.15311732
128G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.13877538
129dendrite morphogenesis (GO:0048813)2.13556243
130positive regulation of cardiac muscle cell differentiation (GO:2000727)2.13369299
131piRNA metabolic process (GO:0034587)2.12569046
132embryonic body morphogenesis (GO:0010172)2.10572237
133protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.09953744
134head development (GO:0060322)2.08520204
135synaptic vesicle endocytosis (GO:0048488)2.08272867
136regulation of centriole replication (GO:0046599)2.07824513
137dorsal/ventral axis specification (GO:0009950)2.07610111
138spindle assembly involved in mitosis (GO:0090307)2.07279200
139positive regulation of mRNA processing (GO:0050685)2.07116799
140glial cell proliferation (GO:0014009)2.06903217
141female gonad development (GO:0008585)2.05364097
142regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.05226065
143somite development (GO:0061053)2.04823034
144negative regulation of hormone metabolic process (GO:0032351)2.01991833
145negative regulation of hormone biosynthetic process (GO:0032353)2.01991833
146positive regulation of neurological system process (GO:0031646)1.99641848
147inner ear receptor cell development (GO:0060119)1.99486252
148protein targeting to Golgi (GO:0000042)1.99308355
149snRNA transcription (GO:0009301)1.98945064
150histone deubiquitination (GO:0016578)1.98181271
151regulation of gene expression by genetic imprinting (GO:0006349)1.97785204
152negative regulation of keratinocyte proliferation (GO:0010839)1.96996748
153histone H4 acetylation (GO:0043967)1.96976639
154positive regulation of meiosis (GO:0045836)1.96903693
155neuron recognition (GO:0008038)1.96383470
156regulation of histone H3-K9 methylation (GO:0051570)1.96364169
157protein K48-linked deubiquitination (GO:0071108)1.96348275
158ionotropic glutamate receptor signaling pathway (GO:0035235)1.96215104
159central nervous system neuron axonogenesis (GO:0021955)1.96162989
160regulation of histone H3-K27 methylation (GO:0061085)1.96052163
161negative regulation of DNA repair (GO:0045738)1.96006295
162spinal cord motor neuron differentiation (GO:0021522)1.95981206
163peptidyl-threonine phosphorylation (GO:0018107)1.95670657
164glutamate receptor signaling pathway (GO:0007215)1.94449674
165histone mRNA catabolic process (GO:0071044)1.94280607

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.79021201
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.23935303
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.10091786
4EZH2_22144423_ChIP-Seq_EOC_Human3.06582200
5GBX2_23144817_ChIP-Seq_PC3_Human2.96539098
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.64798343
7SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.45806000
8ZNF274_21170338_ChIP-Seq_K562_Hela2.39916509
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.34629090
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.13290897
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05472278
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.96889152
13SMAD_19615063_ChIP-ChIP_OVARY_Human1.90929097
14AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.90292017
15FUS_26573619_Chip-Seq_HEK293_Human1.88719464
16VDR_22108803_ChIP-Seq_LS180_Human1.87978422
17HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.83612688
18TP53_16413492_ChIP-PET_HCT116_Human1.78364068
19STAT3_23295773_ChIP-Seq_U87_Human1.74860210
20ZNF217_24962896_ChIP-Seq_MCF-7_Human1.73977791
21TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.73724032
22SMAD4_21799915_ChIP-Seq_A2780_Human1.73281440
23TP63_19390658_ChIP-ChIP_HaCaT_Human1.69330931
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.66827758
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63217244
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63110232
27IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.62957371
28CBP_20019798_ChIP-Seq_JUKART_Human1.62957371
29EWS_26573619_Chip-Seq_HEK293_Human1.60011270
30* AHR_22903824_ChIP-Seq_MCF-7_Human1.57975108
31* ARNT_22903824_ChIP-Seq_MCF-7_Human1.57177978
32TCF4_23295773_ChIP-Seq_U87_Human1.56601149
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55988782
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53520459
35AR_21572438_ChIP-Seq_LNCaP_Human1.53310255
36P300_19829295_ChIP-Seq_ESCs_Human1.51445331
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.50412059
38POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.49013356
39TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49013356
40TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47886570
41DROSHA_22980978_ChIP-Seq_HELA_Human1.45572343
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44044753
43* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.44032537
44TAF15_26573619_Chip-Seq_HEK293_Human1.42784957
45IGF1R_20145208_ChIP-Seq_DFB_Human1.39730355
46* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37468187
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37017802
48NANOG_18555785_Chip-Seq_ESCs_Mouse1.36596129
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.36154566
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.36077354
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.35840259
52FLI1_21867929_ChIP-Seq_TH2_Mouse1.34909106
53TCF4_18268006_ChIP-ChIP_LS174T_Human1.34402342
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33085236
55RNF2_27304074_Chip-Seq_NSC_Mouse1.32338888
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32121581
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31670239
58FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.31207353
59FOXM1_26456572_ChIP-Seq_MCF-7_Human1.29872624
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29007942
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28910721
62YAP1_20516196_ChIP-Seq_MESCs_Mouse1.27868117
63E2F1_18555785_Chip-Seq_ESCs_Mouse1.27400640
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26198258
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25400666
66* AR_19668381_ChIP-Seq_PC3_Human1.24347629
67NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23932287
68RNF2_27304074_Chip-Seq_ESCs_Mouse1.22956217
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22313678
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.22113505
71CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21504527
72* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20367889
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20182429
74* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20125623
75RUNX2_22187159_ChIP-Seq_PCA_Human1.19934211
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19551174
77* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19358698
78AR_25329375_ChIP-Seq_VCAP_Human1.18619627
79EZH2_27304074_Chip-Seq_ESCs_Mouse1.18526610
80TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.18348302
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17822717
82SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.17550295
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17490496
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16835501
85ISL1_27105846_Chip-Seq_CPCs_Mouse1.16768529
86JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16705370
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15972891
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15773396
89IRF1_19129219_ChIP-ChIP_H3396_Human1.14935181
90PKCTHETA_26484144_Chip-Seq_BREAST_Human1.14706176
91SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.13586267
92EZH2_18974828_ChIP-Seq_MESCs_Mouse1.13056103
93RNF2_18974828_ChIP-Seq_MESCs_Mouse1.13056103
94CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12581189
95CTNNB1_20460455_ChIP-Seq_HCT116_Human1.12094118
96PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11955572
97PRDM14_20953172_ChIP-Seq_ESCs_Human1.11352779
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10319123
99SOX9_26525672_Chip-Seq_HEART_Mouse1.10073113
100CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.09850365
101BCAT_22108803_ChIP-Seq_LS180_Human1.08458840
102REST_21632747_ChIP-Seq_MESCs_Mouse1.08380579
103TCF4_22108803_ChIP-Seq_LS180_Human1.08338290
104SMAD4_21741376_ChIP-Seq_EPCs_Human1.07830989
105EED_16625203_ChIP-ChIP_MESCs_Mouse1.07510398
106TAL1_26923725_Chip-Seq_HPCs_Mouse1.07292289
107CBX2_27304074_Chip-Seq_ESCs_Mouse1.07048175
108NFE2_27457419_Chip-Seq_LIVER_Mouse1.06884946
109P53_22387025_ChIP-Seq_ESCs_Mouse1.06425898
110TBL1_22424771_ChIP-Seq_293T_Human1.06390415
111CMYC_18555785_Chip-Seq_ESCs_Mouse1.06192682
112TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06178172
113SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05896638
114TBX3_20139965_ChIP-Seq_MESCs_Mouse1.05577389
115KDM2B_26808549_Chip-Seq_REH_Human1.04347262
116BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03987948
117SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03613272
118TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03192887
119LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02870618
120VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02675851
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02398023
122JUN_21703547_ChIP-Seq_K562_Human1.02224734
123CRX_20693478_ChIP-Seq_RETINA_Mouse1.02150099
124UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01716128
125P300_18555785_Chip-Seq_ESCs_Mouse1.01696973
126STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01426513
127ER_23166858_ChIP-Seq_MCF-7_Human1.01060801
128TP53_22573176_ChIP-Seq_HFKS_Human1.00640085

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting4.80691297
2MP0000569_abnormal_digit_pigmentation4.30383936
3MP0002638_abnormal_pupillary_reflex3.37259302
4MP0003121_genomic_imprinting3.30732613
5MP0008877_abnormal_DNA_methylation3.01209812
6MP0000566_synostosis2.32548944
7MP0003122_maternal_imprinting2.32152251
8MP0003123_paternal_imprinting1.99883438
9MP0003890_abnormal_embryonic-extraembry1.94060377
10MP0000537_abnormal_urethra_morphology1.84814741
11MP0000778_abnormal_nervous_system1.82468778
12MP0004859_abnormal_synaptic_plasticity1.80217062
13MP0003937_abnormal_limbs/digits/tail_de1.70371698
14MP0005257_abnormal_intraocular_pressure1.69275228
15MP0008057_abnormal_DNA_replication1.59948950
16MP0006292_abnormal_olfactory_placode1.58578565
17MP0001984_abnormal_olfaction1.58029510
18MP0005646_abnormal_pituitary_gland1.47940474
19MP0002009_preneoplasia1.45358752
20MP0006276_abnormal_autonomic_nervous1.44435773
21MP0000516_abnormal_urinary_system1.41421000
22MP0005367_renal/urinary_system_phenotyp1.41421000
23MP0005171_absent_coat_pigmentation1.38125875
24MP0002234_abnormal_pharynx_morphology1.37781880
25MP0001299_abnormal_eye_distance/1.36342281
26MP0003755_abnormal_palate_morphology1.35096661
27MP0004270_analgesia1.29900724
28MP0009703_decreased_birth_body1.28488900
29MP0003880_abnormal_central_pattern1.28185997
30MP0001486_abnormal_startle_reflex1.28180684
31MP0003935_abnormal_craniofacial_develop1.28079512
32MP0009780_abnormal_chondrocyte_physiolo1.27532356
33MP0003635_abnormal_synaptic_transmissio1.26303780
34MP0003045_fibrosis1.26154725
35MP0002272_abnormal_nervous_system1.25367027
36MP0006072_abnormal_retinal_apoptosis1.25064071
37MP0001968_abnormal_touch/_nociception1.24547525
38MP0010030_abnormal_orbit_morphology1.23487800
39MP0001188_hyperpigmentation1.23472209
40MP0000631_abnormal_neuroendocrine_gland1.22389622
41MP0002751_abnormal_autonomic_nervous1.21709657
42MP0002102_abnormal_ear_morphology1.20181940
43MP0003385_abnormal_body_wall1.19789470
44MP0001177_atelectasis1.19229491
45MP0005499_abnormal_olfactory_system1.18217938
46MP0005394_taste/olfaction_phenotype1.18217938
47MP0003861_abnormal_nervous_system1.17130475
48MP0004145_abnormal_muscle_electrophysio1.16896435
49MP0003119_abnormal_digestive_system1.15060917
50MP0005645_abnormal_hypothalamus_physiol1.14610958
51MP0001293_anophthalmia1.12852426
52MP0002063_abnormal_learning/memory/cond1.12248174
53MP0003646_muscle_fatigue1.11181819
54MP0000428_abnormal_craniofacial_morphol1.10505201
55MP0005248_abnormal_Harderian_gland1.10001763
56MP0002735_abnormal_chemical_nociception1.08783746
57MP0003567_abnormal_fetal_cardiomyocyte1.08781694
58MP0005503_abnormal_tendon_morphology1.07799967
59* MP0002160_abnormal_reproductive_system1.07106697
60MP0005187_abnormal_penis_morphology1.06831792
61MP0008058_abnormal_DNA_repair1.06289221
62MP0004885_abnormal_endolymph1.05014601
63MP0002233_abnormal_nose_morphology1.04287772
64MP0002084_abnormal_developmental_patter1.04153449
65MP0000647_abnormal_sebaceous_gland1.04092600
66MP0002108_abnormal_muscle_morphology1.03945243
67MP0002064_seizures1.03477097
68MP0000372_irregular_coat_pigmentation1.02778121
69MP0000432_abnormal_head_morphology1.01104441
70MP0003115_abnormal_respiratory_system1.00708177
71* MP0001929_abnormal_gametogenesis1.00399033
72MP0000383_abnormal_hair_follicle0.99385261
73MP0010094_abnormal_chromosome_stability0.99184711
74MP0002736_abnormal_nociception_after0.98217144
75MP0009053_abnormal_anal_canal0.98192425
76MP0002184_abnormal_innervation0.97787538
77MP0008789_abnormal_olfactory_epithelium0.97644563
78MP0002067_abnormal_sensory_capabilities0.97027423
79MP0002116_abnormal_craniofacial_bone0.97009893
80MP0010678_abnormal_skin_adnexa0.96101560
81MP0000015_abnormal_ear_pigmentation0.95688023
82MP0009745_abnormal_behavioral_response0.94939636
83MP0002938_white_spotting0.93716791
84* MP0003698_abnormal_male_reproductive0.93028083
85MP0005551_abnormal_eye_electrophysiolog0.92925979
86MP0002557_abnormal_social/conspecific_i0.92899828
87MP0002572_abnormal_emotion/affect_behav0.91471985
88MP0002152_abnormal_brain_morphology0.91140688
89MP0009250_abnormal_appendicular_skeleto0.90485736
90MP0005253_abnormal_eye_physiology0.89681318
91MP0000955_abnormal_spinal_cord0.89091135
92MP0004147_increased_porphyrin_level0.88809075
93MP0008995_early_reproductive_senescence0.88374173
94MP0005423_abnormal_somatic_nervous0.87536381
95MP0005409_darkened_coat_color0.87182179
96MP0002085_abnormal_embryonic_tissue0.86728355
97MP0005386_behavior/neurological_phenoty0.86503103
98MP0004924_abnormal_behavior0.86503103
99MP0000427_abnormal_hair_cycle0.86498602
100MP0000653_abnormal_sex_gland0.86176077
101MP0003136_yellow_coat_color0.85972450
102MP0009046_muscle_twitch0.85519886
103MP0004197_abnormal_fetal_growth/weight/0.84841965
104MP0001324_abnormal_eye_pigmentation0.83264964
105MP0002837_dystrophic_cardiac_calcinosis0.82724344
106MP0005174_abnormal_tail_pigmentation0.82581148
107MP0004811_abnormal_neuron_physiology0.82288772
108MP0001145_abnormal_male_reproductive0.81945879
109MP0001986_abnormal_taste_sensitivity0.81560916
110MP0002752_abnormal_somatic_nervous0.80983350
111MP0002114_abnormal_axial_skeleton0.80652254
112MP0005380_embryogenesis_phenotype0.80365794
113MP0001672_abnormal_embryogenesis/_devel0.80365794
114MP0004142_abnormal_muscle_tone0.80338212
115MP0002177_abnormal_outer_ear0.79838676
116MP0009672_abnormal_birth_weight0.79585430
117MP0003111_abnormal_nucleus_morphology0.79582933
118MP0002882_abnormal_neuron_morphology0.79559370
119MP0002210_abnormal_sex_determination0.79548131
120MP0000613_abnormal_salivary_gland0.79269126
121MP0001502_abnormal_circadian_rhythm0.79107462
122MP0000462_abnormal_digestive_system0.78271024
123MP0002081_perinatal_lethality0.77014828
124MP0000534_abnormal_ureter_morphology0.75658532
125MP0005391_vision/eye_phenotype0.75338172
126MP0002109_abnormal_limb_morphology0.74930313
127MP0002734_abnormal_mechanical_nocicepti0.73726838
128MP0003315_abnormal_perineum_morphology0.73473659
129MP0005075_abnormal_melanosome_morpholog0.73387816
130MP0010234_abnormal_vibrissa_follicle0.73226564
131* MP0005389_reproductive_system_phenotype0.72491849
132MP0001286_abnormal_eye_development0.72210416
133MP0004215_abnormal_myocardial_fiber0.72118534
134MP0001485_abnormal_pinna_reflex0.71998797
135MP0003938_abnormal_ear_development0.69802531
136MP0002229_neurodegeneration0.68264420
137MP0004043_abnormal_pH_regulation0.68143756

Predicted human phenotypes

RankGene SetZ-score
1Hypoplasia of the fovea (HP:0007750)3.88614995
2Aplasia/Hypoplasia of the fovea (HP:0008060)3.88614995
3Hyperventilation (HP:0002883)3.47188527
4Papillary thyroid carcinoma (HP:0002895)3.29969747
5Abnormality of the fovea (HP:0000493)3.25192595
6Abnormality of the fingertips (HP:0001211)3.04205865
7Abnormality of the labia minora (HP:0012880)3.03298519
8Volvulus (HP:0002580)2.94547055
9Abnormality of the renal cortex (HP:0011035)2.83643176
10Lip pit (HP:0100267)2.75701422
11Abnormality of chromosome stability (HP:0003220)2.68590337
12Aplasia/Hypoplasia of the macula (HP:0008059)2.65379835
13Pancreatic cysts (HP:0001737)2.63558259
14Hip dysplasia (HP:0001385)2.61550026
15Nephronophthisis (HP:0000090)2.55431584
16Optic nerve hypoplasia (HP:0000609)2.51563262
17Renal cortical cysts (HP:0000803)2.49329974
18Abnormality of the renal medulla (HP:0100957)2.44866765
19Aplasia/Hypoplasia affecting the retina (HP:0008061)2.43972576
20Tubulointerstitial nephritis (HP:0001970)2.43682098
21Pancreatic fibrosis (HP:0100732)2.41986415
22Fair hair (HP:0002286)2.40167071
23Medial flaring of the eyebrow (HP:0010747)2.40014693
24Abnormality of the nasal septum (HP:0000419)2.39976963
25Gait imbalance (HP:0002141)2.34912579
26Midline defect of the nose (HP:0004122)2.33278242
27Aplasia/Hypoplasia of the uvula (HP:0010293)2.31544583
28Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.31460046
29Febrile seizures (HP:0002373)2.31388789
30True hermaphroditism (HP:0010459)2.28140603
31Ectopic kidney (HP:0000086)2.25764355
32Chromosomal breakage induced by crosslinking agents (HP:0003221)2.25295487
33Chronic hepatic failure (HP:0100626)2.24838212
34Anal stenosis (HP:0002025)2.22348126
35Protruding tongue (HP:0010808)2.20608939
36Abnormality of the astrocytes (HP:0100707)2.17980178
37Astrocytoma (HP:0009592)2.17980178
38Progressive inability to walk (HP:0002505)2.17639335
39Aplasia/Hypoplasia of the tibia (HP:0005772)2.16161535
40Aqueductal stenosis (HP:0002410)2.15930257
41Congenital primary aphakia (HP:0007707)2.15629378
42Genital tract atresia (HP:0001827)2.14719855
43Trigonocephaly (HP:0000243)2.13724796
44Poor coordination (HP:0002370)2.10336800
45Lissencephaly (HP:0001339)2.09592908
46Chromsome breakage (HP:0040012)2.08151861
47Shawl scrotum (HP:0000049)2.07862714
48Hypoplastic labia majora (HP:0000059)2.07070724
49Nephrogenic diabetes insipidus (HP:0009806)2.06873824
50Thyroiditis (HP:0100646)2.06709813
51Short 4th metacarpal (HP:0010044)2.06329782
52Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.06329782
53Vaginal atresia (HP:0000148)2.05104666
54Absent frontal sinuses (HP:0002688)2.02219199
55Narrow palate (HP:0000189)2.02046893
56Neoplasm of the oral cavity (HP:0100649)2.00236311
57Glioma (HP:0009733)2.00050123
58Difficulty running (HP:0009046)1.97359483
59Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.96776718
60Degeneration of the lateral corticospinal tracts (HP:0002314)1.96776718
61Generalized hypopigmentation of hair (HP:0011358)1.95734328
62Drooling (HP:0002307)1.95287105
63Excessive salivation (HP:0003781)1.95287105
64Truncal obesity (HP:0001956)1.95015446
65Deep philtrum (HP:0002002)1.93864474
66Long eyelashes (HP:0000527)1.92706507
67Medulloblastoma (HP:0002885)1.91682751
68Methylmalonic acidemia (HP:0002912)1.88943255
69Abnormality of the ileum (HP:0001549)1.87170322
70Heterotopia (HP:0002282)1.87057676
71Obsessive-compulsive behavior (HP:0000722)1.86904241
72Abnormality of DNA repair (HP:0003254)1.86384260
73Meckel diverticulum (HP:0002245)1.86268788
74Inability to walk (HP:0002540)1.86196771
75Macroorchidism (HP:0000053)1.86128601
76Abnormality of incisor morphology (HP:0011063)1.85665198
77Thyroid carcinoma (HP:0002890)1.85288732
78Abnormality of the labia majora (HP:0012881)1.85222233
79Clubbing of toes (HP:0100760)1.84733216
80Amyotrophic lateral sclerosis (HP:0007354)1.83796354
81Abnormality of the incisor (HP:0000676)1.83287502
82Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.82383211
83Optic nerve coloboma (HP:0000588)1.81561457
84Abnormal hair whorl (HP:0010721)1.81450895
85Cutaneous finger syndactyly (HP:0010554)1.80340770
86Rhabdomyosarcoma (HP:0002859)1.80108044
87Vertebral arch anomaly (HP:0008438)1.79726847
88Aplasia/Hypoplasia of the lens (HP:0008063)1.79521035
89Cutaneous syndactyly (HP:0012725)1.79477129
90Hepatoblastoma (HP:0002884)1.79444119
91Abnormality of the corticospinal tract (HP:0002492)1.79239431
92Oligodactyly (hands) (HP:0001180)1.79215726
93Astigmatism (HP:0000483)1.78620575
94Ependymoma (HP:0002888)1.78324451
95Type II lissencephaly (HP:0007260)1.77446780
96Neoplasm of the adrenal cortex (HP:0100641)1.76028609
97Impaired vibration sensation in the lower limbs (HP:0002166)1.75351400
98Urethral obstruction (HP:0000796)1.74856234
99Pachygyria (HP:0001302)1.73258209
100Specific learning disability (HP:0001328)1.72580983
101Gonadotropin excess (HP:0000837)1.72464765
102Epileptic encephalopathy (HP:0200134)1.72210376
103Bell-shaped thorax (HP:0001591)1.69595148
104Aplasia/Hypoplasia of the tongue (HP:0010295)1.69261416
105Sloping forehead (HP:0000340)1.68799571
106Atonic seizures (HP:0010819)1.67644450
107Cupped ear (HP:0000378)1.66521798
108Sandal gap (HP:0001852)1.65368004
109Widely spaced teeth (HP:0000687)1.65189303
110Abnormality of chromosome segregation (HP:0002916)1.64593941
111Labial hypoplasia (HP:0000066)1.64139361
112Short tibia (HP:0005736)1.63801712
113Hypoplasia of the maxilla (HP:0000327)1.63423831
114Biliary tract neoplasm (HP:0100574)1.62276579
115Aplasia/Hypoplasia of the sternum (HP:0006714)1.60022102
116Supernumerary ribs (HP:0005815)1.59163754
117Focal seizures (HP:0007359)1.57645293
118Absent speech (HP:0001344)1.57182919
119Decreased lacrimation (HP:0000633)1.56716805
120Intestinal atresia (HP:0011100)1.56517029
121Nephroblastoma (Wilms tumor) (HP:0002667)1.56059450
122Renovascular hypertension (HP:0100817)1.55451469
123Smooth philtrum (HP:0000319)1.55196597
124Absent eyebrow (HP:0002223)1.55127255
125Gaze-evoked nystagmus (HP:0000640)1.54825939
126Gastrointestinal atresia (HP:0002589)1.52395957
127Skull defect (HP:0001362)1.52383977
128Abnormality of midbrain morphology (HP:0002418)1.52187554
129Molar tooth sign on MRI (HP:0002419)1.52187554
130Highly arched eyebrow (HP:0002553)1.50949562
131Progressive cerebellar ataxia (HP:0002073)1.50828912
132Relative macrocephaly (HP:0004482)1.49787048
133Anteriorly placed anus (HP:0001545)1.49216470
134Embryonal renal neoplasm (HP:0011794)1.48781654
135Mask-like facies (HP:0000298)1.48587125
136Urinary bladder sphincter dysfunction (HP:0002839)1.48258881
137Vesicoureteral reflux (HP:0000076)1.47278165
138Blue irides (HP:0000635)1.47172458
139Stomach cancer (HP:0012126)1.46882302
140Limited hip movement (HP:0008800)1.46124678
141Abnormality of the diencephalon (HP:0010662)1.45743564
142Alacrima (HP:0000522)1.45545662
143Gastroesophageal reflux (HP:0002020)1.45460154
144Limited elbow extension (HP:0001377)1.45113277
145Elfin facies (HP:0004428)1.45083753
146Skin pits (HP:0100276)1.44947366
147Micropenis (HP:0000054)1.44812518
148Intestinal fistula (HP:0100819)1.44714136
149Broad-based gait (HP:0002136)1.44700684
150Genetic anticipation (HP:0003743)1.44604260
151Anophthalmia (HP:0000528)1.43954536
152Hypoplastic female external genitalia (HP:0012815)1.43551507
153Abnormality of the antihelix (HP:0009738)1.43283628
154Supernumerary bones of the axial skeleton (HP:0009144)1.42645034
155Subacute progressive viral hepatitis (HP:0006572)1.42504209
156Broad thumb (HP:0011304)1.41589683
157Tapered finger (HP:0001182)1.40909065
158Increased number of teeth (HP:0011069)1.40649004
159Esophageal atresia (HP:0002032)1.39616791
160Aplasia/Hypoplasia of the earlobes (HP:0009906)1.38980531
161Focal motor seizures (HP:0011153)1.38923549

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.63015935
2LATS13.49444828
3AKT33.19314894
4BMPR1B2.51795144
5INSRR2.48679762
6BRD42.44592600
7MAP3K42.35158748
8MAP4K22.26942315
9ZAK2.25553378
10ACVR1B2.19716478
11SGK22.18224866
12FGFR22.02802568
13NTRK31.99242311
14CAMK1D1.83008101
15NUAK11.79017517
16CAMK1G1.72445192
17SGK31.70132369
18PTK2B1.64715714
19MKNK21.63685833
20FRK1.59392810
21EPHA41.58324090
22STK38L1.57721806
23CDC71.55783737
24SGK2231.55489408
25SGK4941.55489408
26NEK61.52810024
27IRAK21.47801328
28CASK1.38902548
29MAP2K71.37918015
30MARK11.37908719
31TAOK31.35130361
32SRPK11.34880796
33TNIK1.32555279
34OXSR11.27260841
35PRPF4B1.25945127
36KSR11.22653296
37STK391.19976494
38CDK31.15436086
39IRAK11.14100296
40ERBB31.13320682
41NTRK21.09974677
42LATS21.09026846
43PINK11.08901792
44CDC42BPA1.05964357
45TRIM281.04754235
46BCR1.04555577
47PLK21.04528568
48WNK11.02871957
49PNCK1.00105028
50STK30.99969899
51PKN20.99230893
52WEE10.98339407
53DYRK1A0.98241097
54DMPK0.95828333
55SGK10.94393879
56ATM0.91756782
57PDGFRB0.90968858
58BRSK20.90578189
59CHEK10.89678054
60MAP3K60.89395584
61MKNK10.89032045
62STK380.88934910
63CSNK1A1L0.88092033
64CHEK20.86621429
65OBSCN0.84681316
66PAK30.84584614
67PLK30.83080927
68MAPK100.81869013
69PASK0.81199588
70ATR0.80656158
71RPS6KB20.78115325
72* MAPK130.75569787
73MELK0.75486541
74MTOR0.74304683
75YES10.74264151
76GSK3B0.74202726
77PIK3CA0.73649513
78MAPK140.71631240
79CSNK1D0.71297191
80WNK30.70359403
81CSNK1G30.69454351
82PAK60.68769137
83CDK10.68197588
84CAMKK20.68133302
85PDGFRA0.67726559
86SIK20.67457494
87EIF2AK30.67310551
88FGFR30.66263518
89DYRK20.66165282
90MARK20.66004557
91PRKDC0.65529330
92PRKAA10.64040704
93CDK20.63128937
94DDR20.62973442
95CDK90.62602180
96PRKCH0.61953552
97FLT30.61834049
98MAP3K90.61396455
99CCNB10.60672417
100FER0.59875922
101MAPK70.58717474
102TTK0.58495047
103EPHA30.58485266
104RPS6KB10.58063339
105MAPK80.57586160
106FGFR10.57030403
107TYRO30.56705077
108PLK40.56522994
109HIPK20.56222781
110GRK10.55935925
111CAMK40.54433836
112CDK50.53969100
113MINK10.52434630
114MAP2K40.52357902
115CSNK1E0.50274531
116SIK30.50067632
117CSNK1G20.49771510
118NLK0.49703401
119PRKCE0.49658393
120DAPK20.48359036
121VRK10.48331046
122RIPK10.48320349
123TEC0.47319810
124STK110.46908310
125RPS6KA30.46494804
126CDK190.45906036
127PRKCG0.44653739
128EPHA20.44191035
129MAP3K20.43984857
130PKN10.43015334
131CSNK1G10.42863003
132PRKCZ0.42387727
133PRKD30.42373798
134PLK10.39076626
135CAMK2A0.38568934
136ERBB20.38318819
137TLK10.37757163
138ADRBK20.36866251
139RET0.36101208
140MAP2K10.35034242
141RAF10.34986679
142PRKACB0.34907985

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050331.98356974
2Maturity onset diabetes of the young_Homo sapiens_hsa049501.95156365
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.67776234
4Circadian entrainment_Homo sapiens_hsa047131.62621562
5Long-term potentiation_Homo sapiens_hsa047201.60302780
6Lysine degradation_Homo sapiens_hsa003101.57288337
7Type II diabetes mellitus_Homo sapiens_hsa049301.55138938
8Circadian rhythm_Homo sapiens_hsa047101.53098463
9mRNA surveillance pathway_Homo sapiens_hsa030151.50925793
10Amphetamine addiction_Homo sapiens_hsa050311.50071255
11Insulin secretion_Homo sapiens_hsa049111.49436002
12Glutamatergic synapse_Homo sapiens_hsa047241.48070469
13Phosphatidylinositol signaling system_Homo sapiens_hsa040701.47292375
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.44237333
15Adherens junction_Homo sapiens_hsa045201.41382468
16Morphine addiction_Homo sapiens_hsa050321.41181291
17Olfactory transduction_Homo sapiens_hsa047401.39379924
18Phototransduction_Homo sapiens_hsa047441.38974367
19Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.36539835
20Taste transduction_Homo sapiens_hsa047421.36465541
21Axon guidance_Homo sapiens_hsa043601.34596587
22Fanconi anemia pathway_Homo sapiens_hsa034601.30973814
23Homologous recombination_Homo sapiens_hsa034401.30292184
24Wnt signaling pathway_Homo sapiens_hsa043101.29077743
25Basal cell carcinoma_Homo sapiens_hsa052171.28578613
26Dopaminergic synapse_Homo sapiens_hsa047281.24316615
27Dorso-ventral axis formation_Homo sapiens_hsa043201.23551882
28Thyroid hormone signaling pathway_Homo sapiens_hsa049191.23117610
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22247364
30GABAergic synapse_Homo sapiens_hsa047271.22160326
31Butanoate metabolism_Homo sapiens_hsa006501.22115666
32ErbB signaling pathway_Homo sapiens_hsa040121.20058979
33Propanoate metabolism_Homo sapiens_hsa006401.19953968
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.19463043
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.19361424
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19128198
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.18849881
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.18836829
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18718451
40Endometrial cancer_Homo sapiens_hsa052131.18516996
41Non-homologous end-joining_Homo sapiens_hsa034501.17808815
42MicroRNAs in cancer_Homo sapiens_hsa052061.17573765
43cAMP signaling pathway_Homo sapiens_hsa040241.16259334
44Regulation of autophagy_Homo sapiens_hsa041401.14655542
45Oxytocin signaling pathway_Homo sapiens_hsa049211.14435992
46Hedgehog signaling pathway_Homo sapiens_hsa043401.13183021
47Nitrogen metabolism_Homo sapiens_hsa009101.13129670
48Cholinergic synapse_Homo sapiens_hsa047251.12032586
49Salivary secretion_Homo sapiens_hsa049701.11707021
50Hippo signaling pathway_Homo sapiens_hsa043901.11667198
51Steroid biosynthesis_Homo sapiens_hsa001001.09840659
52cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08944144
53GnRH signaling pathway_Homo sapiens_hsa049121.06798061
54Dilated cardiomyopathy_Homo sapiens_hsa054141.06704678
55Renin secretion_Homo sapiens_hsa049241.06594215
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05102641
57ABC transporters_Homo sapiens_hsa020101.04985745
58Longevity regulating pathway - mammal_Homo sapiens_hsa042111.03450303
59Choline metabolism in cancer_Homo sapiens_hsa052311.02628703
60TGF-beta signaling pathway_Homo sapiens_hsa043501.02467094
61Prostate cancer_Homo sapiens_hsa052151.01456237
62Calcium signaling pathway_Homo sapiens_hsa040201.01006328
63Long-term depression_Homo sapiens_hsa047301.00785482
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.00329085
65mTOR signaling pathway_Homo sapiens_hsa041500.99351541
66Colorectal cancer_Homo sapiens_hsa052100.98997143
67Serotonergic synapse_Homo sapiens_hsa047260.98823642
68Inositol phosphate metabolism_Homo sapiens_hsa005620.98774220
69Cocaine addiction_Homo sapiens_hsa050300.98349635
70Linoleic acid metabolism_Homo sapiens_hsa005910.98193035
71FoxO signaling pathway_Homo sapiens_hsa040680.98063955
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.97832885
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.97442124
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96941611
75Oocyte meiosis_Homo sapiens_hsa041140.96844691
76Melanogenesis_Homo sapiens_hsa049160.94108358
77Ether lipid metabolism_Homo sapiens_hsa005650.93492594
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.92413388
79Gastric acid secretion_Homo sapiens_hsa049710.91972996
80Alcoholism_Homo sapiens_hsa050340.87013766
81Glioma_Homo sapiens_hsa052140.86212978
82MAPK signaling pathway_Homo sapiens_hsa040100.86109512
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86014612
84Estrogen signaling pathway_Homo sapiens_hsa049150.85855063
85RNA transport_Homo sapiens_hsa030130.85498904
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.84631531
87Basal transcription factors_Homo sapiens_hsa030220.84593443
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84330819
89Tight junction_Homo sapiens_hsa045300.81902946
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81217968
91Selenocompound metabolism_Homo sapiens_hsa004500.80787449
92Cell cycle_Homo sapiens_hsa041100.79529137
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79494572
94Rap1 signaling pathway_Homo sapiens_hsa040150.76800188
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.75974593
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75350899
97Synaptic vesicle cycle_Homo sapiens_hsa047210.74746671
98Focal adhesion_Homo sapiens_hsa045100.74665320
99Gap junction_Homo sapiens_hsa045400.74537271
100Fatty acid biosynthesis_Homo sapiens_hsa000610.74440757
101Ras signaling pathway_Homo sapiens_hsa040140.74350811
102Glucagon signaling pathway_Homo sapiens_hsa049220.74350481
103Proteoglycans in cancer_Homo sapiens_hsa052050.72178792
104RNA degradation_Homo sapiens_hsa030180.71126129
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69627196
106Melanoma_Homo sapiens_hsa052180.68843689
107Pathways in cancer_Homo sapiens_hsa052000.68610124
108Ovarian steroidogenesis_Homo sapiens_hsa049130.68259752
109Thyroid hormone synthesis_Homo sapiens_hsa049180.67146316
110ECM-receptor interaction_Homo sapiens_hsa045120.65980812
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65273339
112Non-small cell lung cancer_Homo sapiens_hsa052230.65081719
113Small cell lung cancer_Homo sapiens_hsa052220.64959878
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64702095
115Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63989913
116Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61973696
117Caffeine metabolism_Homo sapiens_hsa002320.59947578
118Nucleotide excision repair_Homo sapiens_hsa034200.59843079
119Pancreatic secretion_Homo sapiens_hsa049720.58974371
120Insulin resistance_Homo sapiens_hsa049310.58562035
121Prolactin signaling pathway_Homo sapiens_hsa049170.58142487
122Notch signaling pathway_Homo sapiens_hsa043300.58028150
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57983112
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56515193
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.56484693
126Insulin signaling pathway_Homo sapiens_hsa049100.56400612
127Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53752376
128Tryptophan metabolism_Homo sapiens_hsa003800.50491696
129AMPK signaling pathway_Homo sapiens_hsa041520.49446661
130Systemic lupus erythematosus_Homo sapiens_hsa053220.48806884
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47267212

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