BRWD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a bromodomain and several WD repeats. It is thought to have a chromatin-modifying function, and may thus play a role in transcription. Mutations in this gene cause mental retardation X-linked type 93, which is also referred to as mental retardation X-linked with macrocephaly. This gene is also associated with translocations in patients with B-cell chronic lymphocytic leukemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)6.85901163
2nuclear pore complex assembly (GO:0051292)5.71772199
3nuclear pore organization (GO:0006999)5.57090172
4pre-miRNA processing (GO:0031054)5.18768837
5regulation of RNA export from nucleus (GO:0046831)5.11066798
6mitotic chromosome condensation (GO:0007076)4.93229015
7histone H3-K36 demethylation (GO:0070544)4.90555415
8phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.46224629
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.37552223
10positive regulation of gamma-delta T cell activation (GO:0046645)4.36670106
11negative regulation of histone methylation (GO:0031061)4.35877807
12regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.22462931
13pore complex assembly (GO:0046931)4.18111587
14sister chromatid segregation (GO:0000819)4.16674521
15protein localization to kinetochore (GO:0034501)4.15793046
16positive regulation of mitotic sister chromatid separation (GO:1901970)4.14108058
17positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.14108058
18positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.14108058
19kinetochore organization (GO:0051383)4.13170604
20positive regulation by symbiont of host defense response (GO:0052509)4.12730827
21modulation by symbiont of host defense response (GO:0052031)4.12730827
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.12730827
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.12730827
24positive regulation by organism of defense response of other organism involved in symbiotic interact4.12730827
25modulation by symbiont of host immune response (GO:0052553)4.12730827
26cytoplasmic mRNA processing body assembly (GO:0033962)4.12721601
27regulation of sister chromatid cohesion (GO:0007063)4.11424206
28mitotic metaphase plate congression (GO:0007080)4.04955258
29regulation of nucleobase-containing compound transport (GO:0032239)4.03311621
30positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.96217753
31detection of molecule of bacterial origin (GO:0032490)3.89164204
32positive regulation of chromosome segregation (GO:0051984)3.87337433
33regulation of B cell receptor signaling pathway (GO:0050855)3.85665817
34regulation of histone H3-K9 methylation (GO:0051570)3.85553742
35metaphase plate congression (GO:0051310)3.83164859
36monoubiquitinated protein deubiquitination (GO:0035520)3.82621192
37regulation of spindle organization (GO:0090224)3.81598221
38regulation of DNA endoreduplication (GO:0032875)3.81380566
39histone H3-K4 trimethylation (GO:0080182)3.80564432
40sister chromatid cohesion (GO:0007062)3.77194421
41protein localization to chromosome, centromeric region (GO:0071459)3.72782172
42neutrophil mediated immunity (GO:0002446)3.68175478
43negative regulation of translation, ncRNA-mediated (GO:0040033)3.66482303
44regulation of translation, ncRNA-mediated (GO:0045974)3.66482303
45negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.66482303
46mitotic sister chromatid segregation (GO:0000070)3.66184456
47regulation of mitotic spindle organization (GO:0060236)3.53018977
48regulation of centriole replication (GO:0046599)3.48886582
49attachment of spindle microtubules to kinetochore (GO:0008608)3.43640190
50kinetochore assembly (GO:0051382)3.39890999
51mitotic nuclear envelope disassembly (GO:0007077)3.33656467
52microglial cell activation (GO:0001774)3.32640647
53histone H3-K9 methylation (GO:0051567)3.31455970
54cellular extravasation (GO:0045123)3.31252368
55paraxial mesoderm development (GO:0048339)3.28759739
56meiotic chromosome segregation (GO:0045132)3.23128800
57protein localization to chromosome (GO:0034502)3.21813299
58membrane disassembly (GO:0030397)3.21246630
59nuclear envelope disassembly (GO:0051081)3.21246630
60histone H3-K9 demethylation (GO:0033169)3.19818525
61histone H2A monoubiquitination (GO:0035518)3.19383894
62DNA unwinding involved in DNA replication (GO:0006268)3.19102759
63negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.17574716
64negative regulation of cell killing (GO:0031342)3.17574716
65myeloid leukocyte mediated immunity (GO:0002444)3.16099334
66regulation of transforming growth factor beta2 production (GO:0032909)3.14848358
67establishment of chromosome localization (GO:0051303)3.13328713
68chromosome segregation (GO:0007059)3.11692564
69protein K6-linked ubiquitination (GO:0085020)3.11129888
70DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.10491606
71regulation of gamma-delta T cell activation (GO:0046643)3.07375745
72macrophage activation involved in immune response (GO:0002281)3.07061866
73response to host immune response (GO:0052572)3.06223780
74response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.06223780
75negative regulation of DNA repair (GO:0045738)3.05490953
76regulation of centrosome cycle (GO:0046605)3.04885444
77chromatin assembly (GO:0031497)3.04829558
78NLS-bearing protein import into nucleus (GO:0006607)3.04368643
79histone lysine demethylation (GO:0070076)3.04211545
80regulation of chromosome segregation (GO:0051983)3.02283417
81chromatin assembly or disassembly (GO:0006333)3.01756209
82spindle checkpoint (GO:0031577)3.00714606
83hippo signaling (GO:0035329)3.00583645
84DNA geometric change (GO:0032392)3.00107719
85chromosome condensation (GO:0030261)2.99811239
86DNA duplex unwinding (GO:0032508)2.98920176
87negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.98597826
88negative regulation of B cell proliferation (GO:0030889)2.98365539
89negative regulation of fibroblast apoptotic process (GO:2000270)2.96027343
90response to host defenses (GO:0052200)2.96013660
91response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.96013660
92response to host (GO:0075136)2.96013660
93centrosome localization (GO:0051642)2.95097212
94histone mRNA catabolic process (GO:0071044)2.94415253
95histone H3-K9 modification (GO:0061647)2.94404170
96glucocorticoid receptor signaling pathway (GO:0042921)2.93956463
97positive regulation of interferon-alpha production (GO:0032727)2.93589180
98DNA replication-independent nucleosome organization (GO:0034724)2.92635079
99DNA replication-independent nucleosome assembly (GO:0006336)2.92635079
100regulation of protein polyubiquitination (GO:1902914)2.91838253
101DNA damage response, signal transduction resulting in transcription (GO:0042772)2.91332871
102DNA topological change (GO:0006265)2.90712726
103histone demethylation (GO:0016577)2.90298262
104dosage compensation (GO:0007549)2.90076344
105determination of adult lifespan (GO:0008340)2.89782893
106peptidyl-threonine phosphorylation (GO:0018107)2.89155678
107protein dealkylation (GO:0008214)2.87838706
108protein demethylation (GO:0006482)2.87838706
109regulation of interferon-beta biosynthetic process (GO:0045357)2.86533557
110regulation of gamma-delta T cell differentiation (GO:0045586)2.85358167
111regulation of mitotic metaphase/anaphase transition (GO:0030071)2.85157341
112neural tube formation (GO:0001841)2.84309746
113DNA packaging (GO:0006323)2.82138309
114hepatocyte apoptotic process (GO:0097284)2.81422557
115negative regulation of histone modification (GO:0031057)2.81359112
116interkinetic nuclear migration (GO:0022027)2.80712909
117positive regulation of granulocyte differentiation (GO:0030854)2.80654263
118regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.80112191
119corticosteroid receptor signaling pathway (GO:0031958)2.78993505
120regulation of centrosome duplication (GO:0010824)2.77456739
121embryonic process involved in female pregnancy (GO:0060136)2.77414436
122negative regulation of DNA-dependent DNA replication (GO:2000104)2.75554389
123regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.74900116
124positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.74900116
125N-terminal protein amino acid acetylation (GO:0006474)2.74272492
126detection of external biotic stimulus (GO:0098581)2.74109357
127negative regulation of neurotransmitter secretion (GO:0046929)2.74092171
128regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.73253734
129B cell receptor signaling pathway (GO:0050853)2.71865914
130negative regulation of chromatin modification (GO:1903309)2.71506126
131regulation of histone methylation (GO:0031060)2.70696169
132DNA conformation change (GO:0071103)2.70013429
133positive regulation of cell cycle checkpoint (GO:1901978)2.69341390
134heterochromatin organization (GO:0070828)2.69326076
135neutrophil activation involved in immune response (GO:0002283)2.68648482
136microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.67763997
137DNA replication-dependent nucleosome assembly (GO:0006335)2.67655204
138DNA replication-dependent nucleosome organization (GO:0034723)2.67655204
139spindle assembly checkpoint (GO:0071173)2.67276579
140peptidyl-lysine trimethylation (GO:0018023)2.66967136
141peptidyl-threonine modification (GO:0018210)2.66964844
142histone H3-K4 methylation (GO:0051568)2.66467928
143regulation of sister chromatid segregation (GO:0033045)2.66009476
144regulation of mitotic sister chromatid separation (GO:0010965)2.66009476
145regulation of mitotic sister chromatid segregation (GO:0033047)2.66009476
146regulation of interferon-alpha production (GO:0032647)2.65515205
147histone exchange (GO:0043486)2.64966278
148nuclear envelope organization (GO:0006998)2.64889512
149chromatin remodeling at centromere (GO:0031055)2.64839252
150mitotic spindle checkpoint (GO:0071174)2.64069557
151cellular response to ethanol (GO:0071361)2.62150217
152early endosome to late endosome transport (GO:0045022)2.62106461
153detection of other organism (GO:0098543)2.60786723
154protein K48-linked deubiquitination (GO:0071108)2.59330154
155regulation of histone H3-K27 methylation (GO:0061085)2.59059270
156macrophage activation (GO:0042116)2.58378985
157positive regulation of mRNA catabolic process (GO:0061014)2.57413372
158antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.56143319
159detection of biotic stimulus (GO:0009595)2.53427828
160regulation of mRNA catabolic process (GO:0061013)2.52264500
161definitive hemopoiesis (GO:0060216)2.50484919
162regulation of DNA methylation (GO:0044030)2.49804456
163regulation of fibroblast apoptotic process (GO:2000269)2.48529382
164regulation of pigment cell differentiation (GO:0050932)2.48453944
165regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.47709773
166response to interleukin-15 (GO:0070672)2.47257085
167positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.45396078
168regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.45173669
169regulation of NFAT protein import into nucleus (GO:0051532)2.43959064
170positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.41380831
171establishment of protein localization to Golgi (GO:0072600)2.40435339
172positive regulation of interferon-beta production (GO:0032728)2.38694886
173negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.37847278
174negative regulation of T-helper cell differentiation (GO:0045623)2.37847278
175neutrophil activation (GO:0042119)2.36521833
176negative regulation of T cell mediated immunity (GO:0002710)2.36455098
177regulation of chromatin silencing (GO:0031935)2.34879861

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.43554746
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.93714526
3SALL1_21062744_ChIP-ChIP_HESCs_Human5.31581067
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.92637168
5KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.62313551
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.54490055
7TP63_19390658_ChIP-ChIP_HaCaT_Human3.37411073
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.02591175
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.00426091
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.68268203
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.63823084
12AR_21909140_ChIP-Seq_LNCAP_Human2.52457559
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.47171728
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.36711950
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.32621359
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.29147361
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.16246975
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.10455347
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.06700407
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.02934625
21SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.02270294
22GATA1_22025678_ChIP-Seq_K562_Human1.99970130
23RUNX_20019798_ChIP-Seq_JUKART_Human1.88358966
24IRF8_27001747_Chip-Seq_BMDM_Mouse1.86502913
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.83448971
26TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.83116266
27* FUS_26573619_Chip-Seq_HEK293_Human1.81981446
28SCL_19346495_ChIP-Seq_HPC-7_Human1.81472597
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.80652839
30HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.78939703
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78923238
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.75973796
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75788167
34PKCTHETA_26484144_Chip-Seq_BREAST_Human1.70364649
35SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.66565795
36IRF8_21731497_ChIP-ChIP_J774_Mouse1.65568829
37FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.62487077
38* EWS_26573619_Chip-Seq_HEK293_Human1.61629955
39FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.60912995
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60749194
41ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.58647500
42KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.58492444
43KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.58492444
44KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.58492444
45PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.55776663
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.48576457
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47557438
48TAF15_26573619_Chip-Seq_HEK293_Human1.42613386
49* MYB_26560356_Chip-Seq_TH2_Human1.39924638
50VDR_24787735_ChIP-Seq_THP-1_Human1.38647477
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35965086
52RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.29097311
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27289532
54TCF3_18692474_ChIP-Seq_MESCs_Mouse1.26658237
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23355828
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22482320
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22474083
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22030031
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21193671
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21147147
61MYB_26560356_Chip-Seq_TH1_Human1.20935615
62NANOG_21062744_ChIP-ChIP_HESCs_Human1.20514554
63PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20280881
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.20069826
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19739030
66CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19267471
67FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18843424
68NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18601919
69TCF4_18268006_ChIP-ChIP_LS174T_Human1.18501329
70PU_27001747_Chip-Seq_BMDM_Mouse1.15817645
71NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.15601696
72MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15524237
73SALL4_18804426_ChIP-ChIP_XEN_Mouse1.13798951
74NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.12550347
75IGF1R_20145208_ChIP-Seq_DFB_Human1.11203040
76POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.10942829
77ISL1_27105846_Chip-Seq_CPCs_Mouse1.10736518
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08592686
79KDM5A_27292631_Chip-Seq_BREAST_Human1.08391553
80IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07979658
81CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07142318
82SPI1_23127762_ChIP-Seq_K562_Human1.05736090
83FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04964886
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04355775
85P300_19829295_ChIP-Seq_ESCs_Human1.03837275
86CHD1_26751641_Chip-Seq_LNCaP_Human1.03704518
87TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03658821
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03098670
89FOXO3_23340844_ChIP-Seq_DLD1_Human1.02446294
90BRD4_25478319_ChIP-Seq_HGPS_Human1.01703934
91TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01653342
92GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01557188
93TP53_16413492_ChIP-PET_HCT116_Human1.01283606
94AR_21572438_ChIP-Seq_LNCaP_Human1.00539114
95* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00413562
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00317425
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99978557
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99405081
99TCF7_22412390_ChIP-Seq_EML_Mouse0.99086230
100IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.98975361
101SPI1_23547873_ChIP-Seq_NB4_Human0.98921452
102GATA3_27048872_Chip-Seq_THYMUS_Human0.98514248
103SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98459536
104CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96658193
105SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96252823
106DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95740710
107* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95583085
108SMAD4_21799915_ChIP-Seq_A2780_Human0.95580790
109GATA1_19941827_ChIP-Seq_MEL86_Mouse0.95447979
110TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.95203411
111NANOG_18555785_Chip-Seq_ESCs_Mouse0.95133439
112FOXA2_19822575_ChIP-Seq_HepG2_Human0.94355970
113E2F1_18555785_Chip-Seq_ESCs_Mouse0.94254917
114TCF4_23295773_ChIP-Seq_U87_Human0.93775751
115PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93497681
116TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93461883
117SMAD_19615063_ChIP-ChIP_OVARY_Human0.93242573
118YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93228702
119GATA2_19941826_ChIP-Seq_K562_Human0.93048737
120SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.92899212
121POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91955182
122PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91858551
123PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91090281
124GBX2_23144817_ChIP-Seq_PC3_Human0.90735532
125CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90559858
126TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90421835
127SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89616781
128NANOG_18555785_ChIP-Seq_MESCs_Mouse0.88452799
129WT1_19549856_ChIP-ChIP_CCG9911_Human0.88311905
130POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87649053
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87649053
132ELK1_19687146_ChIP-ChIP_HELA_Human0.86461372
133ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84692824
134FOXM1_26456572_ChIP-Seq_MCF-7_Human0.83195813
135HIF1A_21447827_ChIP-Seq_MCF-7_Human0.82179692
136FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.82085192
137SOX2_16153702_ChIP-ChIP_HESCs_Human0.81190899
138ESR1_15608294_ChIP-ChIP_MCF-7_Human0.80771402
139MYC_22102868_ChIP-Seq_BL_Human0.80434442
140ZNF217_24962896_ChIP-Seq_MCF-7_Human0.80373995
141CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.79429948
142MYC_19030024_ChIP-ChIP_MESCs_Mouse0.77971291
143TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.77683715
144STAT6_21828071_ChIP-Seq_BEAS2B_Human0.77105304
145SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.76276202
146CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.76155317
147GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74834660
148STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.74285965
149EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.73838955
150GATA6_25053715_ChIP-Seq_YYC3_Human0.72047205
151MYC_18555785_ChIP-Seq_MESCs_Mouse0.71735129
152STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.71343642
153KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.68860544
154STAT3_23295773_ChIP-Seq_U87_Human0.68674001
155KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.68311710

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability2.94174400
2MP0003121_genomic_imprinting2.78167734
3MP0003111_abnormal_nucleus_morphology2.69520973
4MP0003724_increased_susceptibility_to2.69145498
5MP0005409_darkened_coat_color2.61848032
6MP0008057_abnormal_DNA_replication2.57754378
7MP0003123_paternal_imprinting2.52225183
8MP0003077_abnormal_cell_cycle2.50167348
9MP0003890_abnormal_embryonic-extraembry2.48477652
10MP0003693_abnormal_embryo_hatching2.43823323
11MP0010307_abnormal_tumor_latency2.42137871
12MP0002009_preneoplasia2.35334881
13MP0005076_abnormal_cell_differentiation2.31064954
14MP0003303_peritoneal_inflammation2.29189163
15MP0010352_gastrointestinal_tract_polyps2.27728440
16MP0004957_abnormal_blastocyst_morpholog2.21410488
17MP0003656_abnormal_erythrocyte_physiolo2.21043416
18MP0010030_abnormal_orbit_morphology2.20231933
19MP0003787_abnormal_imprinting2.15397900
20MP0000569_abnormal_digit_pigmentation2.14598292
21MP0005187_abnormal_penis_morphology2.14393444
22MP0003828_pulmonary_edema2.05447157
23MP0003763_abnormal_thymus_physiology2.03712848
24MP0002084_abnormal_developmental_patter1.96419145
25MP0001730_embryonic_growth_arrest1.96037997
26MP0003315_abnormal_perineum_morphology1.94279239
27MP0004381_abnormal_hair_follicle1.93779310
28MP0008877_abnormal_DNA_methylation1.93368940
29MP0005174_abnormal_tail_pigmentation1.89292325
30MP0001835_abnormal_antigen_presentation1.87580354
31MP0000350_abnormal_cell_proliferation1.87234795
32* MP0001672_abnormal_embryogenesis/_devel1.85853739
33* MP0005380_embryogenesis_phenotype1.85853739
34MP0004264_abnormal_extraembryonic_tissu1.79040512
35* MP0003984_embryonic_growth_retardation1.78362854
36MP0000383_abnormal_hair_follicle1.77737386
37* MP0003937_abnormal_limbs/digits/tail_de1.76881340
38MP0010678_abnormal_skin_adnexa1.76731817
39* MP0002088_abnormal_embryonic_growth/wei1.76432110
40MP0003300_gastrointestinal_ulcer1.75841121
41MP0003567_abnormal_fetal_cardiomyocyte1.74661116
42MP0001188_hyperpigmentation1.74573020
43MP0005464_abnormal_platelet_physiology1.73314592
44MP0008007_abnormal_cellular_replicative1.71785398
45MP0002085_abnormal_embryonic_tissue1.71380425
46MP0001697_abnormal_embryo_size1.71000105
47MP0002086_abnormal_extraembryonic_tissu1.69844779
48MP0000537_abnormal_urethra_morphology1.69099657
49MP0004197_abnormal_fetal_growth/weight/1.68693451
50MP0009053_abnormal_anal_canal1.67630553
51MP0003221_abnormal_cardiomyocyte_apopto1.66817917
52MP0010234_abnormal_vibrissa_follicle1.66391660
53MP0001293_anophthalmia1.65103654
54MP0000015_abnormal_ear_pigmentation1.59767346
55MP0003705_abnormal_hypodermis_morpholog1.59648260
56MP0001346_abnormal_lacrimal_gland1.54738212
57MP0003935_abnormal_craniofacial_develop1.53343131
58MP0001800_abnormal_humoral_immune1.53239763
59MP0005248_abnormal_Harderian_gland1.52910718
60MP0008260_abnormal_autophagy1.48545470
61MP0000703_abnormal_thymus_morphology1.45571487
62MP0003941_abnormal_skin_development1.44776910
63MP0003950_abnormal_plasma_membrane1.42351552
64MP0009703_decreased_birth_body1.42148351
65MP0002398_abnormal_bone_marrow1.40920829
66MP0003755_abnormal_palate_morphology1.40123062
67* MP0000432_abnormal_head_morphology1.38338731
68MP0008058_abnormal_DNA_repair1.33223395
69MP0001851_eye_inflammation1.32989630
70MP0008932_abnormal_embryonic_tissue1.31663625
71MP0000733_abnormal_muscle_development1.31374244
72MP0000428_abnormal_craniofacial_morphol1.29148324
73MP0002092_abnormal_eye_morphology1.27336653
74MP0000647_abnormal_sebaceous_gland1.26929384
75MP0002254_reproductive_system_inflammat1.25450887
76MP0004883_abnormal_blood_vessel1.21121436
77MP0004185_abnormal_adipocyte_glucose1.20811166
78MP0000689_abnormal_spleen_morphology1.20774033
79MP0003453_abnormal_keratinocyte_physiol1.19852025
80MP0002722_abnormal_immune_system1.19798229
81MP0005310_abnormal_salivary_gland1.18857852
82MP0003943_abnormal_hepatobiliary_system1.18224937
83MP0001849_ear_inflammation1.17304300
84MP0002080_prenatal_lethality1.15911469
85MP0003183_abnormal_peptide_metabolism1.15851017
86MP0008004_abnormal_stomach_pH1.15787961
87MP0004947_skin_inflammation1.14561276
88MP0002419_abnormal_innate_immunity1.14414731
89MP0002405_respiratory_system_inflammati1.14337353
90MP0005397_hematopoietic_system_phenotyp1.14258420
91MP0001545_abnormal_hematopoietic_system1.14258420
92MP0002420_abnormal_adaptive_immunity1.14178597
93MP0001819_abnormal_immune_cell1.14130033
94MP0002452_abnormal_antigen_presenting1.12745022
95MP0002166_altered_tumor_susceptibility1.12485667
96MP0001286_abnormal_eye_development1.12248508
97MP0001299_abnormal_eye_distance/1.12223429
98MP0005367_renal/urinary_system_phenotyp1.11278040
99MP0000516_abnormal_urinary_system1.11278040
100MP0002697_abnormal_eye_size1.10953032
101MP0000427_abnormal_hair_cycle1.10368770
102MP0002723_abnormal_immune_serum1.09877241
103MP0009672_abnormal_birth_weight1.08094139
104MP0003172_abnormal_lysosome_physiology1.06586150
105MP0002925_abnormal_cardiovascular_devel1.05575474
106MP0003385_abnormal_body_wall1.03851604
107MP0000716_abnormal_immune_system1.03567541
108MP0003119_abnormal_digestive_system1.03258418
109MP0002006_tumorigenesis1.02841106
110MP0003938_abnormal_ear_development1.02357350
111MP0003436_decreased_susceptibility_to1.01469000
112MP0002938_white_spotting1.00746932
113MP0003861_abnormal_nervous_system1.00691548
114MP0000631_abnormal_neuroendocrine_gland0.99042672
115MP0000685_abnormal_immune_system0.98625195
116MP0001915_intracranial_hemorrhage0.98581890
117MP0009697_abnormal_copulation0.98565570
118MP0003566_abnormal_cell_adhesion0.97927593
119MP0003122_maternal_imprinting0.96274167
120MP0002233_abnormal_nose_morphology0.96241384
121MP0000465_gastrointestinal_hemorrhage0.96019485
122MP0002210_abnormal_sex_determination0.91913639
123MP0005000_abnormal_immune_tolerance0.91711653
124MP0009250_abnormal_appendicular_skeleto0.89141923
125MP0005075_abnormal_melanosome_morpholog0.88664625
126MP0003942_abnormal_urinary_system0.88367942
127MP0002396_abnormal_hematopoietic_system0.88032767
128MP0005408_hypopigmentation0.87147104
129MP0002116_abnormal_craniofacial_bone0.87023267
130MP0005666_abnormal_adipose_tissue0.86288605
131MP0002429_abnormal_blood_cell0.85873152
132MP0000566_synostosis0.85705116
133MP0006054_spinal_hemorrhage0.85055217
134MP0008789_abnormal_olfactory_epithelium0.84946778
135MP0000377_abnormal_hair_follicle0.84200013
136MP0000858_altered_metastatic_potential0.83148241
137MP0005671_abnormal_response_to0.82552472
138MP0003690_abnormal_glial_cell0.82113090
139MP0003866_abnormal_defecation0.80870689
140MP0004808_abnormal_hematopoietic_stem0.80824206
141MP0001145_abnormal_male_reproductive0.80365341
142MP0003091_abnormal_cell_migration0.80044601
143MP0001119_abnormal_female_reproductive0.79430978
144MP0000653_abnormal_sex_gland0.78815013
145MP0002177_abnormal_outer_ear0.78414738
146MP0009384_cardiac_valve_regurgitation0.78280272
147MP0002932_abnormal_joint_morphology0.77458493
148MP0003115_abnormal_respiratory_system0.77288286
149MP0009278_abnormal_bone_marrow0.77159913
150MP0004484_altered_response_of0.76674304
151MP0002111_abnormal_tail_morphology0.76587528
152MP0009115_abnormal_fat_cell0.75946693
153MP0005171_absent_coat_pigmentation0.75817527
154MP0005025_abnormal_response_to0.75560577
155MP0003718_maternal_effect0.75545117
156MP0000371_diluted_coat_color0.75448665
157MP0000627_abnormal_mammary_gland0.75301341
158MP0005621_abnormal_cell_physiology0.74674707
159MP0005451_abnormal_body_composition0.74046419

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.68209993
2Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.75441915
3Lip pit (HP:0100267)3.53816431
4Recurrent bacterial skin infections (HP:0005406)3.24683815
5Facial hemangioma (HP:0000329)3.11387514
6Short 4th metacarpal (HP:0010044)3.07443170
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.07443170
8T lymphocytopenia (HP:0005403)3.06374932
9Abnormality of the fingertips (HP:0001211)3.03888295
10Chromsome breakage (HP:0040012)3.01845930
11Eczematoid dermatitis (HP:0000976)2.97661537
12Abnormality of the labia minora (HP:0012880)2.93122024
13Impulsivity (HP:0100710)2.88207292
14Hypochromic microcytic anemia (HP:0004840)2.85963431
15Papillary thyroid carcinoma (HP:0002895)2.75520880
16Spontaneous hematomas (HP:0007420)2.72793537
17Ectopic kidney (HP:0000086)2.69265068
18Abnormality of T cell number (HP:0011839)2.65952649
19Abnormality of incisor morphology (HP:0011063)2.65536541
20Chromosomal breakage induced by crosslinking agents (HP:0003221)2.64537320
21Abnormal hair whorl (HP:0010721)2.58051178
22Long eyelashes (HP:0000527)2.54067264
23Deviation of the thumb (HP:0009603)2.53235519
24Proximal placement of thumb (HP:0009623)2.52777910
25Increased nuchal translucency (HP:0010880)2.51798031
26Recurrent abscess formation (HP:0002722)2.50768667
27Macroorchidism (HP:0000053)2.48866694
28Neonatal hypoglycemia (HP:0001998)2.45131813
29Abnormality of the nasal septum (HP:0000419)2.42374071
30Astrocytoma (HP:0009592)2.42256371
31Abnormality of the astrocytes (HP:0100707)2.42256371
32Abnormality of the distal phalanx of the thumb (HP:0009617)2.41736527
33Embryonal renal neoplasm (HP:0011794)2.40713589
34Heterotopia (HP:0002282)2.38150084
35Thyroid carcinoma (HP:0002890)2.37923959
36Aplasia/Hypoplasia of the sternum (HP:0006714)2.36453238
37Hypoplastic labia majora (HP:0000059)2.35578433
38Medulloblastoma (HP:0002885)2.35241514
39Ependymoma (HP:0002888)2.34165221
40Colon cancer (HP:0003003)2.33306283
41Gingival bleeding (HP:0000225)2.31196604
42Acanthocytosis (HP:0001927)2.30191811
43Anal stenosis (HP:0002025)2.28944531
44Abnormality of chromosome stability (HP:0003220)2.28688735
45Prolonged bleeding time (HP:0003010)2.28424920
46Curly hair (HP:0002212)2.28131604
47Midline defect of the nose (HP:0004122)2.27661726
48Increased number of teeth (HP:0011069)2.24985622
49Conjunctival telangiectasia (HP:0000524)2.24764938
50Abnormality of the 4th metacarpal (HP:0010012)2.23763554
51Neoplasm of the oral cavity (HP:0100649)2.22555864
52Rhabdomyosarcoma (HP:0002859)2.21613728
53Narrow palate (HP:0000189)2.20934798
54Abnormal platelet volume (HP:0011876)2.19339047
55Broad thumb (HP:0011304)2.18138410
56Biliary tract neoplasm (HP:0100574)2.14412563
57Abnormality of the vasculature of the conjunctiva (HP:0008054)2.14222389
58Viral hepatitis (HP:0006562)2.13734418
59Glioma (HP:0009733)2.13386956
60Shawl scrotum (HP:0000049)2.12793478
61Germ cell neoplasia (HP:0100728)2.11061791
62Increased mean platelet volume (HP:0011877)2.10829987
63Deep philtrum (HP:0002002)2.10673718
64Truncal obesity (HP:0001956)2.08007984
65Abnormality of the labia majora (HP:0012881)2.07698303
66Atresia of the external auditory canal (HP:0000413)2.07356007
67Gastrointestinal carcinoma (HP:0002672)2.06918206
68Malignant gastrointestinal tract tumors (HP:0006749)2.06918206
69Abnormality of the columella (HP:0009929)2.04307833
70Gingivitis (HP:0000230)2.03887636
71Prominent nose (HP:0000448)2.02679123
72Obsessive-compulsive behavior (HP:0000722)2.01340300
73Optic neuritis (HP:0100653)2.00590408
74Retrobulbar optic neuritis (HP:0100654)2.00590408
75Transitional cell carcinoma of the bladder (HP:0006740)1.97042880
76Oligodactyly (hands) (HP:0001180)1.96638400
77Abnormality of chromosome segregation (HP:0002916)1.96448623
78Absent frontal sinuses (HP:0002688)1.94653704
79Trigonocephaly (HP:0000243)1.94156796
80Supernumerary ribs (HP:0005815)1.94045244
81Gastrointestinal infarctions (HP:0005244)1.93943345
82Recurrent skin infections (HP:0001581)1.92086805
83Microtia (HP:0008551)1.91772085
84Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.91692683
85Short 1st metacarpal (HP:0010034)1.91692683
86Sparse lateral eyebrow (HP:0005338)1.91678948
87Urethral obstruction (HP:0000796)1.90981582
88Genetic anticipation (HP:0003743)1.89905950
89Neoplasm of striated muscle (HP:0009728)1.88019382
90Acute myeloid leukemia (HP:0004808)1.87835386
91Hypoplasia of the maxilla (HP:0000327)1.85836737
92Diastasis recti (HP:0001540)1.85272532
93Oligodactyly (HP:0012165)1.84856480
94Bladder carcinoma (HP:0002862)1.82875314
95Bladder neoplasm (HP:0009725)1.82875314
96Low anterior hairline (HP:0000294)1.82848398
97Skull defect (HP:0001362)1.80909739
98Rectal prolapse (HP:0002035)1.80499540
99Cortical dysplasia (HP:0002539)1.80425088
100Sandal gap (HP:0001852)1.80010419
101Vertebral arch anomaly (HP:0008438)1.79828364
102Supernumerary spleens (HP:0009799)1.79512845
103Epistaxis (HP:0000421)1.79406144
104Cutis marmorata (HP:0000965)1.78550312
105Recurrent gram-negative bacterial infections (HP:0005420)1.77994125
106Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.77288521
107Broad alveolar ridges (HP:0000187)1.77074552
108Orchitis (HP:0100796)1.76324107
109Subacute progressive viral hepatitis (HP:0006572)1.76081375
110Aqueductal stenosis (HP:0002410)1.74285845
111Abnormality of the left ventricular outflow tract (HP:0011103)1.74117854
112Subaortic stenosis (HP:0001682)1.74117854
113Microglossia (HP:0000171)1.73744467
114Arterial thrombosis (HP:0004420)1.73406280
115Skin pits (HP:0100276)1.72652897
116Neoplasm of the adrenal cortex (HP:0100641)1.72547203
117Esophageal atresia (HP:0002032)1.72397466
118Periodontitis (HP:0000704)1.71962863
119Broad phalanges of the hand (HP:0009768)1.71473265
120Short humerus (HP:0005792)1.70858331
121Peritonitis (HP:0002586)1.70550710
122Recurrent fungal infections (HP:0002841)1.70459682
123Large earlobe (HP:0009748)1.70202991
124Keratoconjunctivitis (HP:0001096)1.69591616
125Supernumerary bones of the axial skeleton (HP:0009144)1.69327592
126Skin tags (HP:0010609)1.68648832
127Hypospadias (HP:0000047)1.66848847
128Neoplasm of the tracheobronchial system (HP:0100552)1.66691640
129Shallow orbits (HP:0000586)1.66137190
130Leiomyosarcoma (HP:0100243)1.66018789
131Uterine leiomyosarcoma (HP:0002891)1.66018789
132Broad ribs (HP:0000885)1.65978259
133Hypopigmentation of the fundus (HP:0007894)1.65882253
134Menorrhagia (HP:0000132)1.65417174
135Periauricular skin pits (HP:0100277)1.65287437
136Preauricular pit (HP:0004467)1.65287437
137Nephroblastoma (Wilms tumor) (HP:0002667)1.64794336
138Chronic mucocutaneous candidiasis (HP:0002728)1.64012310
139Recurrent cutaneous fungal infections (HP:0011370)1.64012310
140Aplasia/Hypoplasia of the uvula (HP:0010293)1.61845332
141Patellar aplasia (HP:0006443)1.61833938
142Embryonal neoplasm (HP:0002898)1.61797731
143Hemivertebrae (HP:0002937)1.61634254
144Keratoconjunctivitis sicca (HP:0001097)1.60969992
145Ankyloglossia (HP:0010296)1.60425738
146Absent radius (HP:0003974)1.60367860
147Poikilocytosis (HP:0004447)1.60338315
148Cafe-au-lait spot (HP:0000957)1.60301419
149Inappropriate behavior (HP:0000719)1.59286123
150Hepatoblastoma (HP:0002884)1.59127513
151Thickened calvaria (HP:0002684)1.59023038
152Blepharitis (HP:0000498)1.58586833
153Overgrowth (HP:0001548)1.58216541
154Fair hair (HP:0002286)1.57776618
155Somatic mutation (HP:0001428)1.57558166
156Tapered finger (HP:0001182)1.57424508
157Birth length less than 3rd percentile (HP:0003561)1.57374877
158Scanning speech (HP:0002168)1.56433290
159Partial agenesis of the corpus callosum (HP:0001338)1.56268912
160Renal cell carcinoma (HP:0005584)1.55317860

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.99266518
2LATS14.55859378
3CDC74.13897652
4STK32.67582126
5NEK22.50915715
6CAMK1D2.33304378
7TNIK2.26971884
8RIPK42.17258506
9BRD42.12521923
10FGFR22.06588739
11MELK2.04624425
12PLK41.98226257
13NLK1.98053610
14CAMK1G1.87760488
15FRK1.87624138
16TTK1.82970498
17FGR1.81835912
18BLK1.78673429
19CDK61.77246548
20LATS21.73085666
21CSK1.69856866
22ACVR1B1.68580436
23CHEK21.67789327
24SRPK11.65460678
25NUAK11.62727466
26TEC1.57798232
27WEE11.55667380
28MAP3K21.54917794
29STK101.54095443
30MKNK21.53160835
31PLK31.50348175
32CHEK11.50239493
33MKNK11.48664981
34AURKB1.48312966
35BTK1.47389435
36ATM1.44128765
37CDK41.39606397
38IRAK41.38962617
39CDK71.37023765
40ATR1.36577764
41STK38L1.36215013
42TAF11.25398432
43MAP3K141.25338395
44PLK11.24414292
45BRSK21.21519194
46MAP2K31.19375815
47SGK2231.16625729
48SGK4941.16625729
49CDK91.16609265
50FGFR31.15225100
51FGFR41.14322926
52YES11.14294762
53IRAK11.12457999
54TYK21.10618998
55STK41.09562344
56PNCK1.07199394
57MTOR1.06805061
58MARK21.04344848
59PDGFRB1.03724376
60CDK21.02917081
61FGFR11.02580915
62BCR1.01457480
63JAK31.00995618
64HCK0.96603110
65AKT30.95829210
66IKBKE0.94660709
67CDK10.91649046
68DYRK30.91136205
69MAP3K60.90282402
70PRPF4B0.90172879
71SYK0.89987715
72SCYL20.89666611
73DMPK0.89528921
74TYRO30.87280349
75JAK10.86756882
76MAP3K80.86537448
77MAP3K10.84825400
78JAK20.84405045
79CSNK1D0.82732300
80KSR10.82706740
81RPS6KB20.81177138
82STK110.79847320
83MATK0.79661597
84CSNK1A1L0.78165264
85RPS6KA40.76986265
86CDK80.75932895
87ERBB40.73445644
88FES0.70609366
89RET0.69415768
90WNK30.68881838
91MAPK140.67300987
92PDGFRA0.66794948
93MAP3K100.65903068
94PKN20.65834127
95WNK10.65812345
96PIM10.65679846
97MAPK100.64471615
98PIK3CG0.64409544
99CDK30.64044704
100DYRK1A0.63466353
101IRAK20.62854515
102CSNK1G10.62578147
103NEK10.60585125
104TXK0.59287417
105CSNK1E0.59148421
106ALK0.58505887
107ZAP700.58122823
108SGK20.57664393
109EGFR0.55937357
110GSK3B0.55313438
111CHUK0.54987784
112LYN0.54411561
113SMG10.53874354
114LCK0.53859344
115PRKDC0.53373667
116MAP3K70.53230774
117TRPM70.52543085
118MARK30.51094394
119BMPR20.50987380
120CAMK40.50844749
121SGK30.50581834
122PLK20.50106753
123MAPK10.49040330
124EEF2K0.48953276
125AKT10.46725650
126BRSK10.46269183
127CASK0.45071593
128PTK60.45052270
129ICK0.44897925
130TAOK30.44172193
131GRK60.43706462
132SIK30.43439988
133RPS6KA50.42727178
134EIF2AK30.41813149
135ERBB20.40697464
136ERBB30.40328692
137ITK0.40194219
138AKT20.39879344
139PRKAA20.38243833
140EPHB20.38191688
141DYRK1B0.37314592
142EPHA20.36344603
143RAF10.36243563
144SGK10.35407364
145STK240.34852387
146CSNK1G20.33512989
147PAK20.33415123
148TSSK60.32893804
149ABL10.32778409
150ZAK0.32276821

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041103.02183454
2RNA transport_Homo sapiens_hsa030132.23561258
3MicroRNAs in cancer_Homo sapiens_hsa052062.16458471
4Fanconi anemia pathway_Homo sapiens_hsa034602.04248593
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.03514242
6mRNA surveillance pathway_Homo sapiens_hsa030151.98362846
7Adherens junction_Homo sapiens_hsa045201.90724823
8Non-homologous end-joining_Homo sapiens_hsa034501.89542894
9Basal transcription factors_Homo sapiens_hsa030221.88575280
10Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.87230355
11Lysine degradation_Homo sapiens_hsa003101.85993457
12TGF-beta signaling pathway_Homo sapiens_hsa043501.85542575
13Mismatch repair_Homo sapiens_hsa034301.83760354
14Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.82586425
15Osteoclast differentiation_Homo sapiens_hsa043801.67185722
16RNA degradation_Homo sapiens_hsa030181.65645675
17Hippo signaling pathway_Homo sapiens_hsa043901.62673009
18Acute myeloid leukemia_Homo sapiens_hsa052211.59877203
19p53 signaling pathway_Homo sapiens_hsa041151.59688651
20Dorso-ventral axis formation_Homo sapiens_hsa043201.58688791
21Small cell lung cancer_Homo sapiens_hsa052221.57233537
22Basal cell carcinoma_Homo sapiens_hsa052171.55521824
23Spliceosome_Homo sapiens_hsa030401.53884025
24Platelet activation_Homo sapiens_hsa046111.47693480
25Leishmaniasis_Homo sapiens_hsa051401.45955438
26Homologous recombination_Homo sapiens_hsa034401.45929196
27Prostate cancer_Homo sapiens_hsa052151.45551586
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.42440350
29Colorectal cancer_Homo sapiens_hsa052101.40074730
30Transcriptional misregulation in cancer_Homo sapiens_hsa052021.39996112
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.38893094
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.36721995
33mTOR signaling pathway_Homo sapiens_hsa041501.36261102
34Measles_Homo sapiens_hsa051621.34607238
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32969133
36DNA replication_Homo sapiens_hsa030301.32310040
37Chronic myeloid leukemia_Homo sapiens_hsa052201.28383563
38Systemic lupus erythematosus_Homo sapiens_hsa053221.28277368
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26963326
40Viral carcinogenesis_Homo sapiens_hsa052031.25839265
41Pancreatic cancer_Homo sapiens_hsa052121.25797002
42Renal cell carcinoma_Homo sapiens_hsa052111.25266079
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.25238525
44Oocyte meiosis_Homo sapiens_hsa041141.25080882
45Nucleotide excision repair_Homo sapiens_hsa034201.23553456
46FoxO signaling pathway_Homo sapiens_hsa040681.22375009
47Herpes simplex infection_Homo sapiens_hsa051681.19332451
48Endometrial cancer_Homo sapiens_hsa052131.17635695
49Wnt signaling pathway_Homo sapiens_hsa043101.15886313
50Chemokine signaling pathway_Homo sapiens_hsa040621.15375441
51Hedgehog signaling pathway_Homo sapiens_hsa043401.12937634
52HTLV-I infection_Homo sapiens_hsa051661.11443644
53Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08767467
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06155397
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04703524
56Proteoglycans in cancer_Homo sapiens_hsa052050.99845420
57Tuberculosis_Homo sapiens_hsa051520.99199629
58Ovarian steroidogenesis_Homo sapiens_hsa049130.99143554
59Non-small cell lung cancer_Homo sapiens_hsa052230.98658764
60Notch signaling pathway_Homo sapiens_hsa043300.98172603
61Autoimmune thyroid disease_Homo sapiens_hsa053200.98119487
62Pathways in cancer_Homo sapiens_hsa052000.97378876
63Hepatitis B_Homo sapiens_hsa051610.97305309
64Base excision repair_Homo sapiens_hsa034100.96309477
65Legionellosis_Homo sapiens_hsa051340.96171783
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93849561
67Thyroid cancer_Homo sapiens_hsa052160.93168614
68One carbon pool by folate_Homo sapiens_hsa006700.92017855
69Tight junction_Homo sapiens_hsa045300.90292029
70Staphylococcus aureus infection_Homo sapiens_hsa051500.88582602
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.88101578
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87721586
73Prolactin signaling pathway_Homo sapiens_hsa049170.87411624
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.87196834
75Malaria_Homo sapiens_hsa051440.87024949
76Amoebiasis_Homo sapiens_hsa051460.81544437
77Long-term potentiation_Homo sapiens_hsa047200.80054062
78Choline metabolism in cancer_Homo sapiens_hsa052310.79877815
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78754536
80Apoptosis_Homo sapiens_hsa042100.78368852
81ErbB signaling pathway_Homo sapiens_hsa040120.77076679
82Epstein-Barr virus infection_Homo sapiens_hsa051690.76408697
83Circadian rhythm_Homo sapiens_hsa047100.75690051
84Viral myocarditis_Homo sapiens_hsa054160.75651045
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75556999
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73604460
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73555759
88Melanoma_Homo sapiens_hsa052180.73455968
89Long-term depression_Homo sapiens_hsa047300.73355142
90RNA polymerase_Homo sapiens_hsa030200.70136248
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70107656
92Type II diabetes mellitus_Homo sapiens_hsa049300.69962914
93African trypanosomiasis_Homo sapiens_hsa051430.69312709
94GnRH signaling pathway_Homo sapiens_hsa049120.68723833
95Hematopoietic cell lineage_Homo sapiens_hsa046400.67078322
96Phototransduction_Homo sapiens_hsa047440.65974733
97Insulin resistance_Homo sapiens_hsa049310.65867236
98T cell receptor signaling pathway_Homo sapiens_hsa046600.65533827
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.64457885
100Glioma_Homo sapiens_hsa052140.63207123
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.62414061
102Focal adhesion_Homo sapiens_hsa045100.62138619
103Antigen processing and presentation_Homo sapiens_hsa046120.61875350
104Bladder cancer_Homo sapiens_hsa052190.61385309
105Insulin signaling pathway_Homo sapiens_hsa049100.61220507
106Ras signaling pathway_Homo sapiens_hsa040140.61188383
107Fatty acid biosynthesis_Homo sapiens_hsa000610.60381649
108Axon guidance_Homo sapiens_hsa043600.59290049
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58409688
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57059179
111Influenza A_Homo sapiens_hsa051640.56959048
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53697317
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53447285
114VEGF signaling pathway_Homo sapiens_hsa043700.53311768
115Alcoholism_Homo sapiens_hsa050340.52915549
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.52655651
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52231151
118Toxoplasmosis_Homo sapiens_hsa051450.51924922
119Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51861879
120Gap junction_Homo sapiens_hsa045400.51542338
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51363313
122Estrogen signaling pathway_Homo sapiens_hsa049150.51254229
123TNF signaling pathway_Homo sapiens_hsa046680.50766358
124Ether lipid metabolism_Homo sapiens_hsa005650.50525310
125AMPK signaling pathway_Homo sapiens_hsa041520.49614431
126MAPK signaling pathway_Homo sapiens_hsa040100.48952312
127Regulation of autophagy_Homo sapiens_hsa041400.48836362
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46537604
129B cell receptor signaling pathway_Homo sapiens_hsa046620.46485411
130HIF-1 signaling pathway_Homo sapiens_hsa040660.46380757
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.44842242
132Melanogenesis_Homo sapiens_hsa049160.43600548
133Rap1 signaling pathway_Homo sapiens_hsa040150.43544307
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43029159
135Hepatitis C_Homo sapiens_hsa051600.41992685
136Inositol phosphate metabolism_Homo sapiens_hsa005620.39859195

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