BSDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.49059518
2L-phenylalanine catabolic process (GO:0006559)5.49059518
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.96940808
4L-phenylalanine metabolic process (GO:0006558)4.96940808
5fatty acid elongation (GO:0030497)4.54587466
6aromatic amino acid family catabolic process (GO:0009074)4.34831610
7response to methylmercury (GO:0051597)4.30776104
8axon ensheathment in central nervous system (GO:0032291)4.27881777
9central nervous system myelination (GO:0022010)4.27881777
10gas transport (GO:0015669)4.17981863
11oxygen transport (GO:0015671)4.17005882
12cysteine metabolic process (GO:0006534)4.05086231
13protoporphyrinogen IX metabolic process (GO:0046501)3.91238699
14Golgi transport vesicle coating (GO:0048200)3.73365437
15COPI coating of Golgi vesicle (GO:0048205)3.73365437
16alpha-linolenic acid metabolic process (GO:0036109)3.72304923
17negative regulation of erythrocyte differentiation (GO:0045647)3.69113595
18glyoxylate metabolic process (GO:0046487)3.63387615
19bile acid biosynthetic process (GO:0006699)3.60790186
20protoporphyrinogen IX biosynthetic process (GO:0006782)3.49384943
21triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.48534054
22heme transport (GO:0015886)3.45906625
23short-chain fatty acid metabolic process (GO:0046459)3.43566020
24acetyl-CoA metabolic process (GO:0006084)3.39351590
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.38383890
26indole-containing compound catabolic process (GO:0042436)3.32441962
27indolalkylamine catabolic process (GO:0046218)3.32441962
28tryptophan catabolic process (GO:0006569)3.32441962
29creatine metabolic process (GO:0006600)3.29705343
30fatty-acyl-CoA biosynthetic process (GO:0046949)3.27650339
31very long-chain fatty acid metabolic process (GO:0000038)3.27270527
32drug transmembrane transport (GO:0006855)3.25677010
33negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.25150262
34glutamate metabolic process (GO:0006536)3.24862884
35cerebellar granule cell differentiation (GO:0021707)3.24664396
36regulation of triglyceride catabolic process (GO:0010896)3.23688460
37plasma lipoprotein particle clearance (GO:0034381)3.22791579
38retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.22718615
39sulfur amino acid catabolic process (GO:0000098)3.21554310
40kynurenine metabolic process (GO:0070189)3.20613775
41lysine metabolic process (GO:0006553)3.19135997
42lysine catabolic process (GO:0006554)3.19135997
43long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.18615445
44hemoglobin metabolic process (GO:0020027)3.18024989
45aspartate family amino acid catabolic process (GO:0009068)3.17199871
46acyl-CoA biosynthetic process (GO:0071616)3.16652689
47thioester biosynthetic process (GO:0035384)3.16652689
48coenzyme catabolic process (GO:0009109)3.15859815
49tryptophan metabolic process (GO:0006568)3.13856982
50fatty-acyl-CoA metabolic process (GO:0035337)3.13063796
51bile acid metabolic process (GO:0008206)3.11644571
52peptidyl-glutamic acid carboxylation (GO:0017187)3.11623370
53protein carboxylation (GO:0018214)3.11623370
54regulation of synaptic vesicle exocytosis (GO:2000300)3.06883920
55negative regulation of fibrinolysis (GO:0051918)3.05865741
56amino-acid betaine metabolic process (GO:0006577)3.01737217
57tyrosine metabolic process (GO:0006570)3.01206453
58regulation of ARF protein signal transduction (GO:0032012)2.97294289
59aromatic amino acid family metabolic process (GO:0009072)2.97281459
60acylglycerol homeostasis (GO:0055090)2.96779674
61triglyceride homeostasis (GO:0070328)2.96779674
62high-density lipoprotein particle remodeling (GO:0034375)2.96487385
63positive regulation of receptor recycling (GO:0001921)2.96246994
64urea cycle (GO:0000050)2.95252343
65urea metabolic process (GO:0019627)2.95252343
66cellular ketone body metabolic process (GO:0046950)2.94922733
67regulation of fibrinolysis (GO:0051917)2.93776798
68synaptic vesicle maturation (GO:0016188)2.93619147
69long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.91608782
70regulation of cholesterol metabolic process (GO:0090181)2.90281027
71acyl-CoA metabolic process (GO:0006637)2.90220006
72thioester metabolic process (GO:0035383)2.90220006
73very-low-density lipoprotein particle assembly (GO:0034379)2.89863197
74pyrimidine nucleobase catabolic process (GO:0006208)2.89033796
75regulation of cholesterol homeostasis (GO:2000188)2.88112858
76complement activation, alternative pathway (GO:0006957)2.87189482
77alpha-amino acid catabolic process (GO:1901606)2.85105898
78iron coordination entity transport (GO:1901678)2.85100785
79fatty acid oxidation (GO:0019395)2.85082017
80negative regulation of digestive system process (GO:0060457)2.84553587
81cholesterol efflux (GO:0033344)2.83920793
82synaptic vesicle exocytosis (GO:0016079)2.83847300
83ensheathment of neurons (GO:0007272)2.83538240
84axon ensheathment (GO:0008366)2.83538240
85regulation of protein activation cascade (GO:2000257)2.82738341
86nitrogen cycle metabolic process (GO:0071941)2.82611818
87response to mercury ion (GO:0046689)2.82539638
88drug catabolic process (GO:0042737)2.82339324
89regulation of cholesterol biosynthetic process (GO:0045540)2.81788379
90cofactor catabolic process (GO:0051187)2.81613146
91synaptic vesicle docking involved in exocytosis (GO:0016081)2.81135568
92fatty acid catabolic process (GO:0009062)2.81035292
93fatty acid beta-oxidation (GO:0006635)2.80240639
94lipid oxidation (GO:0034440)2.78521239
95ethanol oxidation (GO:0006069)2.78392020
96cholesterol biosynthetic process (GO:0006695)2.78219349
97plasma lipoprotein particle assembly (GO:0034377)2.77346353
98myelination (GO:0042552)2.76752865
99import into cell (GO:0098657)2.76617938
100cellular amino acid catabolic process (GO:0009063)2.75923560
101glycerophospholipid catabolic process (GO:0046475)2.75878386
102cell migration in hindbrain (GO:0021535)2.75097380
103regulation of bile acid biosynthetic process (GO:0070857)2.74121231
104positive regulation of lipoprotein lipase activity (GO:0051006)2.73215833
105positive regulation of triglyceride lipase activity (GO:0061365)2.73215833
106fibrinolysis (GO:0042730)2.72682218
107serine family amino acid catabolic process (GO:0009071)2.72367151
108protein-lipid complex assembly (GO:0065005)2.72316550
109glutamate secretion (GO:0014047)2.70496286
110myelin maintenance (GO:0043217)2.69808220
111vesicle coating (GO:0006901)2.69526542
112monocarboxylic acid catabolic process (GO:0072329)2.69510274
113cytoskeletal anchoring at plasma membrane (GO:0007016)2.66898111
114regulation of response to osmotic stress (GO:0047484)2.66824533
115response to lead ion (GO:0010288)2.66799137
116regulation of T-helper 2 cell differentiation (GO:0045628)2.65564363
117glutathione biosynthetic process (GO:0006750)2.64748422
118cellular modified amino acid catabolic process (GO:0042219)2.64707642
119homocysteine metabolic process (GO:0050667)2.63586146
120negative regulation of lipase activity (GO:0060192)2.63382124
121protein localization to endosome (GO:0036010)2.62684594
122positive regulation of lipid catabolic process (GO:0050996)2.62544649
123regulation of complement activation (GO:0030449)2.62540016
124regulation of short-term neuronal synaptic plasticity (GO:0048172)2.61986400
125phospholipid efflux (GO:0033700)2.61936070
126reverse cholesterol transport (GO:0043691)2.60668667
127regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.59562187
128erythrocyte development (GO:0048821)2.59371979
129positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.55255663
130mannose metabolic process (GO:0006013)2.54057202
131stress fiber assembly (GO:0043149)2.50548788
132cellular response to catecholamine stimulus (GO:0071870)2.49692570
133cellular response to monoamine stimulus (GO:0071868)2.49692570
134neuronal ion channel clustering (GO:0045161)2.45096826
135protein targeting to plasma membrane (GO:0072661)2.43440807
136protein retention in ER lumen (GO:0006621)2.42196010
137regulation of synaptic vesicle transport (GO:1902803)2.42058366
138regulation of cAMP-dependent protein kinase activity (GO:2000479)2.41568284
139L-serine transport (GO:0015825)2.35735932
140layer formation in cerebral cortex (GO:0021819)2.34700022
141activation of protein kinase A activity (GO:0034199)2.32118786
142negative regulation of microtubule polymerization (GO:0031115)2.29231599
143G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.29031533
144regulation of chromatin binding (GO:0035561)2.27983217
145erythrocyte maturation (GO:0043249)2.25335485
146proline biosynthetic process (GO:0006561)2.24928069
147nucleobase catabolic process (GO:0046113)2.23413707
148negative regulation of fatty acid biosynthetic process (GO:0045717)2.21308553
149regulation of ARF GTPase activity (GO:0032312)2.21070554
150maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.20339112
151clathrin coat assembly (GO:0048268)2.18967028
152histone H3-K9 demethylation (GO:0033169)2.18930859
153sodium ion export (GO:0071436)2.18165341
154cell-cell junction maintenance (GO:0045217)2.18000676
155linoleic acid metabolic process (GO:0043651)2.14572617
156regulation of amyloid precursor protein catabolic process (GO:1902991)2.14526501
157neurotransmitter secretion (GO:0007269)2.13017887
158cellular response to epinephrine stimulus (GO:0071872)2.12037735
159macroautophagy (GO:0016236)2.11978766
160embryonic process involved in female pregnancy (GO:0060136)2.11432296
161histone H4 deacetylation (GO:0070933)2.10594260
162regulation of cholesterol esterification (GO:0010872)2.10360663
163low-density lipoprotein particle clearance (GO:0034383)2.10166617
164regulation of early endosome to late endosome transport (GO:2000641)2.09299760
165activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.08673170
166one-carbon compound transport (GO:0019755)2.08659758
167regulation of clathrin-mediated endocytosis (GO:2000369)2.08534147
168regulation of beta-amyloid formation (GO:1902003)2.07252246
169intracellular estrogen receptor signaling pathway (GO:0030520)2.05050002
170porphyrin-containing compound biosynthetic process (GO:0006779)2.04837368
171actin filament capping (GO:0051693)2.04234374
172establishment of mitochondrion localization (GO:0051654)2.02953924
173proline metabolic process (GO:0006560)2.02278650
174positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.02155486
175modulation by virus of host process (GO:0019054)2.02134175
176response to monoamine (GO:0071867)2.01929674
177response to catecholamine (GO:0071869)2.01929674
178amyloid precursor protein catabolic process (GO:0042987)2.01419764
179receptor recycling (GO:0001881)2.00318693
180negative regulation of fatty acid transport (GO:2000192)2.00233758
181cell volume homeostasis (GO:0006884)1.98840099
182activation of MAPKKK activity (GO:0000185)1.98680937
183amyloid precursor protein metabolic process (GO:0042982)1.98468385
184neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)1.98031510
185protein insertion into membrane (GO:0051205)1.97337112
186negative regulation of adherens junction organization (GO:1903392)1.96754994
187negative regulation of cell junction assembly (GO:1901889)1.96754994

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.41194443
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.04004011
3LXR_22158963_ChIP-Seq_LIVER_Mouse3.63802402
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.42266558
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.92242702
6EGR1_23403033_ChIP-Seq_LIVER_Mouse2.81614330
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.40286404
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.37805345
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.34800829
10LXR_22292898_ChIP-Seq_THP-1_Human2.32603122
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.27321334
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.24726349
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.24314955
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.16968768
15* GATA1_19941826_ChIP-Seq_K562_Human2.04601111
16GATA1_22025678_ChIP-Seq_K562_Human2.02544156
17ELK3_25401928_ChIP-Seq_HUVEC_Human1.95290175
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.92400576
19KDM2B_26808549_Chip-Seq_DND41_Human1.91221710
20TCF7_22412390_ChIP-Seq_EML_Mouse1.89764403
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.86602681
22ZFP281_18757296_ChIP-ChIP_E14_Mouse1.81421734
23* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.76474808
24EZH2_22144423_ChIP-Seq_EOC_Human1.74461675
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73788399
26CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.72676535
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.71925664
28DNAJC2_21179169_ChIP-ChIP_NT2_Human1.63772716
29CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.62609326
30* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.58743153
31KDM2B_26808549_Chip-Seq_JURKAT_Human1.56277490
32RACK7_27058665_Chip-Seq_MCF-7_Human1.56146361
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.55301182
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.55101057
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.53584782
36FOXA2_19822575_ChIP-Seq_HepG2_Human1.52954786
37ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.52025117
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.49879023
39FOXO3_23340844_ChIP-Seq_DLD1_Human1.49437281
40NCOR1_26117541_ChIP-Seq_K562_Human1.48147600
41SCL_19346495_ChIP-Seq_HPC-7_Human1.47127868
42CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.45820823
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45470106
44TRIM28_21343339_ChIP-Seq_HEK293_Human1.44585056
45* CREB1_26743006_Chip-Seq_LNCaP_Human1.42077754
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41160594
47CLOCK_20551151_ChIP-Seq_293T_Human1.37850956
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36405346
49* GATA2_19941826_ChIP-Seq_K562_Human1.35245087
50* SA1_27219007_Chip-Seq_ERYTHROID_Human1.34780762
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.34313505
52TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34164354
53* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33960441
54SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32630277
55SMC4_20622854_ChIP-Seq_HELA_Human1.31573415
56* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29366543
57* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29296402
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29118335
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26819469
60SPI1_23127762_ChIP-Seq_K562_Human1.25923380
61GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25748752
62ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21222254
63* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.21051364
64VDR_21846776_ChIP-Seq_THP-1_Human1.20194057
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.20105760
66CTCF_27219007_Chip-Seq_Bcells_Human1.18889844
67* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.18603095
68CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16350085
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16056335
70MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14919861
71TAF15_26573619_Chip-Seq_HEK293_Human1.14497880
72P68_20966046_ChIP-Seq_HELA_Human1.14373208
73TET1_21490601_ChIP-Seq_MESCs_Mouse1.13851129
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13319807
75SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13247953
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12222037
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12095916
78TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.11228644
79ELF1_20517297_ChIP-Seq_JURKAT_Human1.10676158
80ZNF263_19887448_ChIP-Seq_K562_Human1.09009168
81MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.08898693
82SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08609495
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08335495
84ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08136787
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06928810
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06752706
87RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06329559
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.05042542
89VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04718230
90MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03545594
91MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.03344339
92RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02432966
93TET1_21451524_ChIP-Seq_MESCs_Mouse1.02306853
94EGR1_19374776_ChIP-ChIP_THP-1_Human1.01625966
95SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01615812
96ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01361988
97SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01094451
98NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00514340
99NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99003875
100NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99003875
101TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.98548195
102TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98112387
103EP300_21415370_ChIP-Seq_HL-1_Mouse0.97636145
104SUZ12_27294783_Chip-Seq_ESCs_Mouse0.97271057
105DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96907036
106SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96828871
107CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95504483
108RUNX1_22412390_ChIP-Seq_EML_Mouse0.95295965
109SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95289852
110UTX_26944678_Chip-Seq_JUKART_Human0.94950072
111NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94788953
112IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94770476
113CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94036359
114* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.93975732
115OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93877711
116BCOR_27268052_Chip-Seq_Bcells_Human0.93825785
117Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.93631443
118DROSHA_22980978_ChIP-Seq_HELA_Human0.93135411
119ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92948918
120PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92676975
121EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91883466
122FOXA1_25552417_ChIP-Seq_VCAP_Human0.91315466
123SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.90825439
124WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89650060
125AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87474667
126TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.86828386
127ESR1_20079471_ChIP-ChIP_T-47D_Human0.86820922
128GATA2_21666600_ChIP-Seq_HMVEC_Human0.86628443
129CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.85646531
130PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85527148
131NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85407597
132ESR1_21235772_ChIP-Seq_MCF-7_Human0.85336208
133EZH2_27294783_Chip-Seq_ESCs_Mouse0.84903241
134FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84287494
135AHR_22903824_ChIP-Seq_MCF-7_Human0.83929177
136EZH2_18974828_ChIP-Seq_MESCs_Mouse0.83213333
137RNF2_18974828_ChIP-Seq_MESCs_Mouse0.83213333
138FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.82892470
139KDM2B_26808549_Chip-Seq_K562_Human0.81802918
140AR_21572438_ChIP-Seq_LNCaP_Human0.81055516
141WT1_19549856_ChIP-ChIP_CCG9911_Human0.79951293
142ER_23166858_ChIP-Seq_MCF-7_Human0.79814170
143OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79076166
144STAT6_21828071_ChIP-Seq_BEAS2B_Human0.78989567
145SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.78663053
146* TBX20_22328084_ChIP-Seq_HEART_Mouse0.78579144
147* TBX20_22080862_ChIP-Seq_HEART_Mouse0.78579144
148CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.78089507
149GATA4_25053715_ChIP-Seq_YYC3_Human0.78005471
150EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.77825677
151ARNT_22903824_ChIP-Seq_MCF-7_Human0.77653081
152PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.77522360
153SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.77139945
154GBX2_23144817_ChIP-Seq_PC3_Human0.76166439
155HTT_18923047_ChIP-ChIP_STHdh_Human0.75732366
156JARID2_20064375_ChIP-Seq_MESCs_Mouse0.75274639
157* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.75040360
158PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.75007436
159SMAD3_21741376_ChIP-Seq_EPCs_Human0.74930098
160TP63_23658742_ChIP-Seq_EP156T_Human0.73862701
161SALL4_18804426_ChIP-ChIP_XEN_Mouse0.73670860
162SOX2_20726797_ChIP-Seq_SW620_Human0.72942701
163STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.72923389
164SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.72650552
165SMAD4_21741376_ChIP-Seq_HESCs_Human0.72277418
166VDR_24787735_ChIP-Seq_THP-1_Human0.71575900
167* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.70956791
168PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.70731527
169GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70538952
170ERG_21242973_ChIP-ChIP_JURKAT_Human0.70249387

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.54152953
2MP0005360_urolithiasis5.05921457
3MP0005085_abnormal_gallbladder_physiolo4.18006690
4MP0005365_abnormal_bile_salt3.95100266
5MP0003656_abnormal_erythrocyte_physiolo3.80920650
6MP0008875_abnormal_xenobiotic_pharmacok3.67446237
7MP0004859_abnormal_synaptic_plasticity3.30140886
8MP0005083_abnormal_biliary_tract3.14819803
9MP0003806_abnormal_nucleotide_metabolis2.85123894
10MP0004147_increased_porphyrin_level2.66149440
11MP0003195_calcinosis2.51862519
12MP0003252_abnormal_bile_duct2.47959746
13MP0009840_abnormal_foam_cell2.42936849
14MP0000920_abnormal_myelination2.36543833
15MP0002138_abnormal_hepatobiliary_system2.36055916
16MP0010329_abnormal_lipoprotein_level2.34146583
17MP0005332_abnormal_amino_acid2.25316456
18MP0003690_abnormal_glial_cell2.22462967
19MP0001666_abnormal_nutrient_absorption2.18662299
20MP0003879_abnormal_hair_cell2.05732784
21MP0005464_abnormal_platelet_physiology2.01890220
22MP0003705_abnormal_hypodermis_morpholog2.00789445
23MP0005409_darkened_coat_color1.99880022
24MP0002118_abnormal_lipid_homeostasis1.99453530
25MP0003172_abnormal_lysosome_physiology1.98922061
26MP0008438_abnormal_cutaneous_collagen1.95617005
27MP0003329_amyloid_beta_deposits1.94462576
28MP0002837_dystrophic_cardiac_calcinosis1.87240268
29MP0005451_abnormal_body_composition1.85993769
30MP0008995_early_reproductive_senescence1.85774347
31MP0003303_peritoneal_inflammation1.80602305
32MP0005423_abnormal_somatic_nervous1.69874667
33MP0003191_abnormal_cellular_cholesterol1.67070931
34MP0003880_abnormal_central_pattern1.66555937
35MP0003635_abnormal_synaptic_transmissio1.66294050
36MP0000609_abnormal_liver_physiology1.57544377
37MP0000604_amyloidosis1.57241676
38MP0005397_hematopoietic_system_phenotyp1.52511382
39MP0001545_abnormal_hematopoietic_system1.52511382
40MP0003566_abnormal_cell_adhesion1.51237900
41MP0002653_abnormal_ependyma_morphology1.50993030
42MP0003436_decreased_susceptibility_to1.48719544
43MP0004043_abnormal_pH_regulation1.46125742
44MP0009278_abnormal_bone_marrow1.43349378
45MP0009643_abnormal_urine_homeostasis1.41703997
46MP0004019_abnormal_vitamin_homeostasis1.41355106
47MP0008569_lethality_at_weaning1.39481280
48MP0002254_reproductive_system_inflammat1.39242680
49MP0004185_abnormal_adipocyte_glucose1.38145828
50MP0005636_abnormal_mineral_homeostasis1.36437738
51MP0005584_abnormal_enzyme/coenzyme_acti1.35228974
52MP0004130_abnormal_muscle_cell1.35056809
53MP0002063_abnormal_learning/memory/cond1.34441798
54MP0009384_cardiac_valve_regurgitation1.31627478
55MP0004270_analgesia1.30918825
56MP0004811_abnormal_neuron_physiology1.24342796
57MP0001502_abnormal_circadian_rhythm1.22529451
58MP0002796_impaired_skin_barrier1.21402846
59MP0003868_abnormal_feces_composition1.19482663
60MP0001958_emphysema1.18309264
61MP0005167_abnormal_blood-brain_barrier1.17743998
62MP0001765_abnormal_ion_homeostasis1.15676186
63MP0003828_pulmonary_edema1.14962102
64MP0003279_aneurysm1.14429869
65MP0008004_abnormal_stomach_pH1.13891033
66MP0003091_abnormal_cell_migration1.11913459
67MP0003122_maternal_imprinting1.11455258
68MP0004885_abnormal_endolymph1.08900192
69MP0005319_abnormal_enzyme/_coenzyme1.07934057
70MP0002089_abnormal_postnatal_growth/wei1.06037132
71MP0002971_abnormal_brown_adipose1.05670580
72MP0004510_myositis1.05075731
73MP0005058_abnormal_lysosome_morphology1.03540710
74MP0006138_congestive_heart_failure1.01674776
75MP0009765_abnormal_xenobiotic_induced1.01107506
76MP0001529_abnormal_vocalization1.01075873
77MP0005275_abnormal_skin_tensile1.00353389
78MP0005535_abnormal_body_temperature0.99640282
79MP0005076_abnormal_cell_differentiation0.98712156
80MP0002909_abnormal_adrenal_gland0.98517338
81MP0010678_abnormal_skin_adnexa0.98225114
82MP0001661_extended_life_span0.97891401
83MP0005666_abnormal_adipose_tissue0.97775511
84MP0003221_abnormal_cardiomyocyte_apopto0.95350770
85MP0003634_abnormal_glial_cell0.92978143
86MP0002249_abnormal_larynx_morphology0.91888791
87MP0003950_abnormal_plasma_membrane0.91721060
88MP0000681_abnormal_thyroid_gland0.91045144
89MP0004947_skin_inflammation0.90629785
90MP0001915_intracranial_hemorrhage0.89740980
91MP0005375_adipose_tissue_phenotype0.84827570
92MP0000678_abnormal_parathyroid_gland0.84689421
93MP0002734_abnormal_mechanical_nocicepti0.84460334
94MP0000778_abnormal_nervous_system0.84385559
95MP0004036_abnormal_muscle_relaxation0.83065757
96MP0000747_muscle_weakness0.82066383
97MP0005647_abnormal_sex_gland0.81437257
98MP0003453_abnormal_keratinocyte_physiol0.80676953
99MP0001756_abnormal_urination0.80416093
100MP0002078_abnormal_glucose_homeostasis0.79281011
101MP0002735_abnormal_chemical_nociception0.78824016
102MP0002822_catalepsy0.78459499
103MP0005670_abnormal_white_adipose0.77438841
104MP0002882_abnormal_neuron_morphology0.77108620
105MP0004742_abnormal_vestibular_system0.76835494
106MP0005410_abnormal_fertilization0.75715826
107MP0002064_seizures0.75620088
108MP0001440_abnormal_grooming_behavior0.74755665
109MP0005171_absent_coat_pigmentation0.74546774
110MP0000465_gastrointestinal_hemorrhage0.74175964
111MP0004142_abnormal_muscle_tone0.73909098
112MP0008874_decreased_physiological_sensi0.73876496
113MP0002229_neurodegeneration0.73770137
114MP0000003_abnormal_adipose_tissue0.73179755
115MP0000230_abnormal_systemic_arterial0.73151971
116MP0006276_abnormal_autonomic_nervous0.73079711
117MP0001849_ear_inflammation0.72792092
118MP0009764_decreased_sensitivity_to0.72516863
119MP0002733_abnormal_thermal_nociception0.72444524
120MP0001764_abnormal_homeostasis0.72433635
121MP0008775_abnormal_heart_ventricle0.72368550
122MP0004883_abnormal_blood_vessel0.72343338
123MP0005334_abnormal_fat_pad0.72171626
124MP0003075_altered_response_to0.72062552
125MP0003632_abnormal_nervous_system0.71669225
126MP0001486_abnormal_startle_reflex0.70717591
127MP0001970_abnormal_pain_threshold0.70066041
128MP0005310_abnormal_salivary_gland0.69813064
129MP0000955_abnormal_spinal_cord0.69784962
130MP0002066_abnormal_motor_capabilities/c0.69022079
131MP0003948_abnormal_gas_homeostasis0.68729425
132MP0002876_abnormal_thyroid_physiology0.68484699
133MP0005408_hypopigmentation0.67786978
134MP0000383_abnormal_hair_follicle0.65871488
135MP0002132_abnormal_respiratory_system0.65468787
136MP0000249_abnormal_blood_vessel0.65212284
137MP0002572_abnormal_emotion/affect_behav0.64534029
138MP0003633_abnormal_nervous_system0.64425978
139MP0002136_abnormal_kidney_physiology0.63988586
140MP0001533_abnormal_skeleton_physiology0.63980805
141MP0002557_abnormal_social/conspecific_i0.62587925
142MP0009763_increased_sensitivity_to0.62284661
143MP0001851_eye_inflammation0.61865860
144MP0003631_nervous_system_phenotype0.61434237
145MP0002332_abnormal_exercise_endurance0.60677443
146MP0002295_abnormal_pulmonary_circulatio0.59993845
147MP0009642_abnormal_blood_homeostasis0.59844193
148MP0003186_abnormal_redox_activity0.59702883
149MP0001346_abnormal_lacrimal_gland0.59266604
150MP0002090_abnormal_vision0.58416350
151MP0008260_abnormal_autophagy0.57261787
152MP0005501_abnormal_skin_physiology0.56543268
153MP0006036_abnormal_mitochondrial_physio0.55641903
154MP0003724_increased_susceptibility_to0.54759746
155MP0005376_homeostasis/metabolism_phenot0.54325409
156MP0000598_abnormal_liver_morphology0.51620452
157MP0005164_abnormal_response_to0.50074240
158MP0003300_gastrointestinal_ulcer0.49777804
159MP0006082_CNS_inflammation0.49463558
160MP0008469_abnormal_protein_level0.49376573
161MP0005620_abnormal_muscle_contractility0.49233977
162MP0000462_abnormal_digestive_system0.48857262

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.28173629
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.65779700
3Deep venous thrombosis (HP:0002625)4.61869841
4Xanthomatosis (HP:0000991)4.23398643
5Poikilocytosis (HP:0004447)4.17146148
6Acanthocytosis (HP:0001927)4.07334365
7Neurofibrillary tangles (HP:0002185)3.97502097
8Hyperlipoproteinemia (HP:0010980)3.83212521
9Hypobetalipoproteinemia (HP:0003563)3.50014881
10Abnormal gallbladder morphology (HP:0012437)3.48074254
11Abnormality of monocarboxylic acid metabolism (HP:0010996)3.47471452
12Cholelithiasis (HP:0001081)3.45147543
13Ketosis (HP:0001946)3.44299579
14Hypochromic microcytic anemia (HP:0004840)3.34649786
15Prolonged partial thromboplastin time (HP:0003645)3.30744534
16Cerebral inclusion bodies (HP:0100314)3.26957628
17Complement deficiency (HP:0004431)3.12172719
18Degeneration of the lateral corticospinal tracts (HP:0002314)3.01790305
19Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.01790305
20Prolonged bleeding time (HP:0003010)2.99614496
21Hypolipoproteinemia (HP:0010981)2.88139264
22Hyperammonemia (HP:0001987)2.86914525
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.84755219
24Ankle clonus (HP:0011448)2.82733933
25Ketoacidosis (HP:0001993)2.82731157
26Abnormality of glycine metabolism (HP:0010895)2.82248268
27Abnormality of serine family amino acid metabolism (HP:0010894)2.82248268
28Hyporeflexia of lower limbs (HP:0002600)2.82075390
29Cholecystitis (HP:0001082)2.82037132
30Abnormal gallbladder physiology (HP:0012438)2.82037132
31Hyperbilirubinemia (HP:0002904)2.81466073
32Abnormality of the common coagulation pathway (HP:0010990)2.79830055
33Obstructive sleep apnea (HP:0002870)2.79398766
34Abnormality of glutamine family amino acid metabolism (HP:0010902)2.79027131
35Menorrhagia (HP:0000132)2.78358923
36Cerebral hemorrhage (HP:0001342)2.78119210
37Reticulocytosis (HP:0001923)2.76311105
38Hypoglycemic coma (HP:0001325)2.76204157
39Hypoalphalipoproteinemia (HP:0003233)2.71867611
40Parakeratosis (HP:0001036)2.68680242
41Fat malabsorption (HP:0002630)2.67180857
42Abnormality of the heme biosynthetic pathway (HP:0010472)2.65510699
43Hand muscle atrophy (HP:0009130)2.64488019
44Abnormality of sulfur amino acid metabolism (HP:0004339)2.58048066
45Hyperglycinemia (HP:0002154)2.57828670
46Upper limb amyotrophy (HP:0009129)2.56631348
47Distal upper limb amyotrophy (HP:0007149)2.56631348
48Gout (HP:0001997)2.54960946
49Hyperglycinuria (HP:0003108)2.54949594
50Epidermoid cyst (HP:0200040)2.54571824
51Abnormality of the corticospinal tract (HP:0002492)2.53672416
52Abnormality of the gallbladder (HP:0005264)2.50493110
53Hemorrhage of the eye (HP:0011885)2.50265045
54Mitral stenosis (HP:0001718)2.48337022
55Abnormality of aspartate family amino acid metabolism (HP:0010899)2.47871772
56Growth hormone excess (HP:0000845)2.46404535
57Hammertoe (HP:0001765)2.44578501
58Rickets (HP:0002748)2.43984049
59Abnormality of reticulocytes (HP:0004312)2.42163748
60Paralysis (HP:0003470)2.41756918
61Amyloidosis (HP:0011034)2.37806604
62Polycythemia (HP:0001901)2.37730570
63Onion bulb formation (HP:0003383)2.36336990
64Abnormality of fatty-acid metabolism (HP:0004359)2.34527950
65Global brain atrophy (HP:0002283)2.32367418
66Distal lower limb amyotrophy (HP:0008944)2.28225910
67Protrusio acetabuli (HP:0003179)2.26993234
68Abnormal hemoglobin (HP:0011902)2.25772532
69Metabolic acidosis (HP:0001942)2.25397628
70Cerebral aneurysm (HP:0004944)2.24736932
71Vascular calcification (HP:0004934)2.22829173
72Joint hemorrhage (HP:0005261)2.20163391
73Confusion (HP:0001289)2.19369495
74Purpura (HP:0000979)2.18475456
75Abnormality of purine metabolism (HP:0004352)2.17207027
76Increased mean platelet volume (HP:0011877)2.16894907
77Abnormality of methionine metabolism (HP:0010901)2.16244220
78Hypophosphatemic rickets (HP:0004912)2.15364617
79Hypercortisolism (HP:0001578)2.14969001
80Gingival bleeding (HP:0000225)2.13572622
81Epistaxis (HP:0000421)2.13232692
82Spastic gait (HP:0002064)2.13162606
83Atelectasis (HP:0100750)2.12106655
84Exercise-induced myalgia (HP:0003738)2.10706378
85Diaphragmatic weakness (HP:0009113)2.10531661
86Hyperinsulinemic hypoglycemia (HP:0000825)2.10191533
87Spastic paraparesis (HP:0002313)2.09920037
88Intention tremor (HP:0002080)2.09340205
89Decreased motor nerve conduction velocity (HP:0003431)2.07382910
90Neoplasm of the heart (HP:0100544)2.07234669
91Increased circulating renin level (HP:0000848)2.06859076
92Hypoglycemic seizures (HP:0002173)2.05529695
93Steatorrhea (HP:0002570)2.04640471
94Muscle fiber splitting (HP:0003555)2.04281238
95Neuronal loss in central nervous system (HP:0002529)2.04167095
96Abnormal platelet volume (HP:0011876)2.03410524
97Insomnia (HP:0100785)2.02092233
98Hypercholesterolemia (HP:0003124)2.01936386
99Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.00949377
100Upper limb muscle weakness (HP:0003484)1.99728578
101Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.99014229
102Axonal loss (HP:0003447)1.97768525
103Abnormality of binocular vision (HP:0011514)1.95598209
104Diplopia (HP:0000651)1.95598209
105Polyphagia (HP:0002591)1.94593804
106Myocardial infarction (HP:0001658)1.94236989
107Bowel incontinence (HP:0002607)1.93874600
108Hypokalemic alkalosis (HP:0001949)1.93699399
109Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93528321
110Cardiovascular calcification (HP:0011915)1.91485475
111Abnormality of complement system (HP:0005339)1.91109082
112Abnormal large intestine physiology (HP:0012700)1.89342560
113Lower limb amyotrophy (HP:0007210)1.89083747
114Peripheral hypomyelination (HP:0007182)1.89062045
115Supranuclear gaze palsy (HP:0000605)1.89027695
116Easy fatigability (HP:0003388)1.87748881
117Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.87714861
118Postural instability (HP:0002172)1.86406379
119Spastic tetraparesis (HP:0001285)1.85925489
120Difficulty climbing stairs (HP:0003551)1.85759590
121Peripheral demyelination (HP:0011096)1.85676328
122Eczematoid dermatitis (HP:0000976)1.85664224
123Truncus arteriosus (HP:0001660)1.85585653
124Interstitial pulmonary disease (HP:0006530)1.85274876
125Spontaneous abortion (HP:0005268)1.84426083
126Distal sensory impairment (HP:0002936)1.84321493
127Arterial tortuosity (HP:0005116)1.84282831
128Ileus (HP:0002595)1.84111875
129Conjugated hyperbilirubinemia (HP:0002908)1.83669770
130Alkalosis (HP:0001948)1.82816346
131Systemic lupus erythematosus (HP:0002725)1.82608690
132Congenital ichthyosiform erythroderma (HP:0007431)1.82399876
133Abnormality of proline metabolism (HP:0010907)1.81820917
134Hydroxyprolinuria (HP:0003080)1.81820917
135Paraparesis (HP:0002385)1.81514184
136Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.81350622
137Hypoplasia of the iris (HP:0007676)1.80124078
138Aneurysm (HP:0002617)1.79865217
139Sleep apnea (HP:0010535)1.79419246
140Insidious onset (HP:0003587)1.79271539
141Termporal pattern (HP:0011008)1.79271539
142Increased purine levels (HP:0004368)1.79004817
143Hyperuricemia (HP:0002149)1.79004817
144Foot dorsiflexor weakness (HP:0009027)1.78779064
145Testicular neoplasm (HP:0010788)1.78099459
146Abnormality of the fingertips (HP:0001211)1.77492929
147Disproportionate tall stature (HP:0001519)1.77332260
148Germ cell neoplasia (HP:0100728)1.77245053
149Abnormality of the intrinsic pathway (HP:0010989)1.76869837
150Increased variability in muscle fiber diameter (HP:0003557)1.76862693
151Abnormal platelet function (HP:0011869)1.76860293
152Impaired platelet aggregation (HP:0003540)1.76860293
153Dysostosis multiplex (HP:0000943)1.76323248
154Microcytic anemia (HP:0001935)1.75080452
155Segmental peripheral demyelination/remyelination (HP:0003481)1.74241996
156Abnormality of the Achilles tendon (HP:0005109)1.73987649
157Sensorimotor neuropathy (HP:0007141)1.73555366
158Sensory axonal neuropathy (HP:0003390)1.73113695
159Hepatocellular carcinoma (HP:0001402)1.72826088
160Hypoventilation (HP:0002791)1.72012989
161Metabolic alkalosis (HP:0200114)1.71872021
162Slow saccadic eye movements (HP:0000514)1.71483796
163Protuberant abdomen (HP:0001538)1.71351784
164Cervical subluxation (HP:0003308)1.70793551
165Abnormal eating behavior (HP:0100738)1.70755980
166Broad palm (HP:0001169)1.69754308
167Myokymia (HP:0002411)1.69117112
168Vascular tortuosity (HP:0004948)1.68636302
169Skin nodule (HP:0200036)1.67524515
170Aortic aneurysm (HP:0004942)1.66933146
171Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.66013743
172Depression (HP:0000716)1.65155323
173Lower limb muscle weakness (HP:0007340)1.65093614
174Hypertriglyceridemia (HP:0002155)1.61562594
175Metaphyseal cupping (HP:0003021)1.61135508
176Dysmetric saccades (HP:0000641)1.59165161

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.86862233
2EPHB13.74768940
3WNK43.42828750
4OXSR13.17952582
5PRPF4B2.85906750
6MARK12.20640149
7BCKDK2.19728714
8RIPK12.03181812
9ICK1.99024971
10WNK11.92721940
11PKN11.91772358
12CAMK1G1.87966276
13MAPK151.83717950
14FGFR21.70409790
15TAOK31.69547905
16ERN11.68664836
17INSRR1.64557842
18FGFR41.59233911
19SIK11.55948707
20MST41.55288695
21KSR11.53816060
22SIK21.52973279
23NTRK31.47102858
24MET1.46695930
25MAP3K61.44093559
26PNCK1.41059938
27PAK31.39485267
28SIK31.37888184
29EEF2K1.36645109
30CAMK1D1.36188460
31NTRK11.35456287
32PKN21.26803519
33MAP3K31.25917674
34MAPKAPK51.25066856
35CDK121.23452477
36PRKD31.18197212
37EPHA41.16263217
38MAP2K31.12726506
39PRKAA21.10781238
40PDGFRA1.08084715
41PRKCQ1.07885283
42STK381.06797690
43TAOK11.05239945
44MAP3K111.03011033
45DDR21.01675277
46PDPK11.01214810
47DMPK1.01021291
48SGK4941.00929840
49SGK2231.00929840
50EPHA31.00801287
51FGR0.99075177
52MAP3K40.98273672
53PRKD20.97186202
54ERBB40.97160672
55FGFR30.95122156
56MAP3K20.94787338
57MARK20.94271418
58GSK3A0.94199603
59MAP2K70.93455589
60TAOK20.93252985
61MELK0.92796586
62BCR0.91690629
63PAK60.91107290
64CSNK1A1L0.90137872
65CDK190.89327433
66CLK10.88509471
67ITK0.86531832
68CSNK1G30.85056478
69RAF10.83685742
70DYRK1A0.83060814
71TESK10.82690573
72RPS6KA20.81958193
73MAPK120.81524171
74ROCK20.80655939
75CDC42BPA0.80321185
76JAK20.80230979
77NTRK20.78903974
78SGK30.78726286
79IRAK20.77786501
80CSNK1G20.76669882
81PRKD10.76625554
82PRKAA10.76010290
83TBK10.75980197
84JAK10.75707252
85ZAP700.74128519
86PTK20.73247686
87STK110.72682185
88IRAK30.72640747
89TYRO30.72044964
90PTK60.71390488
91CAMK2B0.70701157
92CAMK2G0.69875812
93DYRK20.68352916
94DYRK1B0.68347062
95CSNK1G10.67990041
96BMPR20.67248303
97MINK10.67071527
98PHKG10.67037495
99PHKG20.67037495
100MTOR0.66313718
101FER0.66220128
102MAP3K50.66085980
103DAPK20.65535130
104MAP3K70.64985470
105LMTK20.63441565
106TRPM70.62519474
107DYRK30.62506020
108PTK2B0.62051689
109MAP2K20.61643945
110MAP3K10.61571589
111PDK10.61505467
112IRAK10.61472632
113HIPK20.61289617
114MAP2K40.60792576
115CAMK2D0.60717394
116CAMKK10.60393867
117TRIB30.60148953
118PDGFRB0.58605159
119CSK0.57984220
120GRK70.57910775
121ERBB20.57719098
122MAPK110.56668989
123WNK30.56538699
124RIPK40.56454277
125AKT30.55975604
126SGK20.55871140
127MST1R0.54882544
128PIM20.54673218
129UHMK10.54151970
130STK100.53386066
131CAMK2A0.53006908
132PRKCH0.51308447
133CDK50.51011907
134KSR20.50976328
135GRK60.50918788
136TYK20.50477759
137EIF2AK10.49794680
138TIE10.48369339
139MAPK40.48274930
140GRK50.48178896
141TNK20.47780139
142MAPK100.47678652
143PRKACG0.47657506
144RPS6KA50.47538452
145RET0.46970014
146MAP2K10.46660233
147PIK3CG0.46432707
148NEK60.46021792
149PRKCZ0.45952012
150SGK10.45665730
151LATS10.44043381
152BMX0.43516871
153FYN0.42916473
154MAPK70.41595988

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.21135859
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.99651774
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.64233201
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.50877469
5Butanoate metabolism_Homo sapiens_hsa006502.42298811
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.40736757
7Fatty acid elongation_Homo sapiens_hsa000622.31301990
8Arginine biosynthesis_Homo sapiens_hsa002202.26761544
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.24824175
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.17448903
11Tryptophan metabolism_Homo sapiens_hsa003802.16213898
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15280123
13Fatty acid degradation_Homo sapiens_hsa000712.14687892
14Propanoate metabolism_Homo sapiens_hsa006402.12832482
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.12106415
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.99239565
17Steroid biosynthesis_Homo sapiens_hsa001001.96865404
18Synaptic vesicle cycle_Homo sapiens_hsa047211.92670774
19Fatty acid metabolism_Homo sapiens_hsa012121.92188188
20Histidine metabolism_Homo sapiens_hsa003401.91662404
21Sulfur metabolism_Homo sapiens_hsa009201.81116229
22Complement and coagulation cascades_Homo sapiens_hsa046101.76414998
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.72474691
24PPAR signaling pathway_Homo sapiens_hsa033201.71512102
25Vitamin B6 metabolism_Homo sapiens_hsa007501.70281121
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.67933303
27Peroxisome_Homo sapiens_hsa041461.66168484
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.60975625
29beta-Alanine metabolism_Homo sapiens_hsa004101.53260715
30Other glycan degradation_Homo sapiens_hsa005111.50052110
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.47156914
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.43387551
33Bile secretion_Homo sapiens_hsa049761.37348421
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.37164073
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.36488690
36ABC transporters_Homo sapiens_hsa020101.35352187
37Notch signaling pathway_Homo sapiens_hsa043301.34926632
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.34551101
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.31844436
40Pyruvate metabolism_Homo sapiens_hsa006201.30987737
41Phenylalanine metabolism_Homo sapiens_hsa003601.29189538
42Non-small cell lung cancer_Homo sapiens_hsa052231.28735495
43Inositol phosphate metabolism_Homo sapiens_hsa005621.27672845
44Acute myeloid leukemia_Homo sapiens_hsa052211.23537517
45Staphylococcus aureus infection_Homo sapiens_hsa051501.23414170
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.22180224
47Chemical carcinogenesis_Homo sapiens_hsa052041.22177165
48Chronic myeloid leukemia_Homo sapiens_hsa052201.20110515
49VEGF signaling pathway_Homo sapiens_hsa043701.19767786
50Choline metabolism in cancer_Homo sapiens_hsa052311.19553454
51Retinol metabolism_Homo sapiens_hsa008301.19405552
52Endometrial cancer_Homo sapiens_hsa052131.15878155
53Phospholipase D signaling pathway_Homo sapiens_hsa040721.15629826
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14852668
55Steroid hormone biosynthesis_Homo sapiens_hsa001401.14837875
56Tyrosine metabolism_Homo sapiens_hsa003501.14317744
57Fat digestion and absorption_Homo sapiens_hsa049751.13456642
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10543949
59Arginine and proline metabolism_Homo sapiens_hsa003301.09924473
60ErbB signaling pathway_Homo sapiens_hsa040121.06906886
61Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06336203
62Gap junction_Homo sapiens_hsa045401.06277394
63Fatty acid biosynthesis_Homo sapiens_hsa000611.05546013
64Neurotrophin signaling pathway_Homo sapiens_hsa047221.04998634
65Pancreatic cancer_Homo sapiens_hsa052121.04372273
66Long-term potentiation_Homo sapiens_hsa047201.01220370
67Vibrio cholerae infection_Homo sapiens_hsa051100.99429190
68Glioma_Homo sapiens_hsa052140.99285553
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.99210442
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97223944
71Prolactin signaling pathway_Homo sapiens_hsa049170.96713444
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96078798
73Glycerolipid metabolism_Homo sapiens_hsa005610.95979080
74Vitamin digestion and absorption_Homo sapiens_hsa049770.95549421
75GnRH signaling pathway_Homo sapiens_hsa049120.91589070
76Insulin signaling pathway_Homo sapiens_hsa049100.90377104
77mTOR signaling pathway_Homo sapiens_hsa041500.90361105
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90251839
79Estrogen signaling pathway_Homo sapiens_hsa049150.85602198
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83894669
81Starch and sucrose metabolism_Homo sapiens_hsa005000.82946131
82Ether lipid metabolism_Homo sapiens_hsa005650.81862369
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81089431
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80410321
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79797345
86Amphetamine addiction_Homo sapiens_hsa050310.78541469
87Platelet activation_Homo sapiens_hsa046110.78528231
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78508242
89Caffeine metabolism_Homo sapiens_hsa002320.77336172
90Fructose and mannose metabolism_Homo sapiens_hsa000510.74900777
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74532948
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.73928126
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73577457
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73039016
95Cholinergic synapse_Homo sapiens_hsa047250.70976194
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70450413
97HIF-1 signaling pathway_Homo sapiens_hsa040660.69957158
98Collecting duct acid secretion_Homo sapiens_hsa049660.69620569
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68980230
100Nicotine addiction_Homo sapiens_hsa050330.68145351
101Glutamatergic synapse_Homo sapiens_hsa047240.67832705
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.67036003
103FoxO signaling pathway_Homo sapiens_hsa040680.66589546
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66481886
105Hepatitis C_Homo sapiens_hsa051600.65137911
106Osteoclast differentiation_Homo sapiens_hsa043800.65102809
107Linoleic acid metabolism_Homo sapiens_hsa005910.64919706
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64255674
109Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63701478
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.63011173
111Cyanoamino acid metabolism_Homo sapiens_hsa004600.62553388
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62493497
113Lysine degradation_Homo sapiens_hsa003100.61323258
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60250422
115Glutathione metabolism_Homo sapiens_hsa004800.59598141
116Rap1 signaling pathway_Homo sapiens_hsa040150.58485477
117Dopaminergic synapse_Homo sapiens_hsa047280.58062112
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.57785606
119Carbon metabolism_Homo sapiens_hsa012000.56845867
120Morphine addiction_Homo sapiens_hsa050320.56819065
121Hepatitis B_Homo sapiens_hsa051610.55784154
122Focal adhesion_Homo sapiens_hsa045100.54606531
123Amoebiasis_Homo sapiens_hsa051460.54483312
124Prostate cancer_Homo sapiens_hsa052150.54200332
125Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53345126
126Colorectal cancer_Homo sapiens_hsa052100.53124171
127B cell receptor signaling pathway_Homo sapiens_hsa046620.51783540
128Folate biosynthesis_Homo sapiens_hsa007900.50511793
129Dorso-ventral axis formation_Homo sapiens_hsa043200.48592560
130Chemokine signaling pathway_Homo sapiens_hsa040620.48269224
131ECM-receptor interaction_Homo sapiens_hsa045120.48208569
132Insulin resistance_Homo sapiens_hsa049310.43320478
133Cysteine and methionine metabolism_Homo sapiens_hsa002700.42671734
134Selenocompound metabolism_Homo sapiens_hsa004500.41194717
135Sphingolipid metabolism_Homo sapiens_hsa006000.39482647
136Prion diseases_Homo sapiens_hsa050200.35974040
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34986272
138AMPK signaling pathway_Homo sapiens_hsa041520.33109954
139Metabolic pathways_Homo sapiens_hsa011000.32431490
140Biosynthesis of amino acids_Homo sapiens_hsa012300.31213487
141Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30978032
142Drug metabolism - other enzymes_Homo sapiens_hsa009830.30568443
143GABAergic synapse_Homo sapiens_hsa047270.29164213
144Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28804625
145Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28453727
146Ovarian steroidogenesis_Homo sapiens_hsa049130.28062818
147Mineral absorption_Homo sapiens_hsa049780.26408432
148Renal cell carcinoma_Homo sapiens_hsa052110.25836392
149Pancreatic secretion_Homo sapiens_hsa049720.22825917
150Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22020391
151Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.21890528
152Lysosome_Homo sapiens_hsa041420.21743547
153Axon guidance_Homo sapiens_hsa043600.21080010
154Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.20541958
155Renin secretion_Homo sapiens_hsa049240.19500689
156Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.18633417
157Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.17228794
158Type II diabetes mellitus_Homo sapiens_hsa049300.17002405
159Oxidative phosphorylation_Homo sapiens_hsa001900.16682923
160Sulfur relay system_Homo sapiens_hsa041220.11774115
161Vascular smooth muscle contraction_Homo sapiens_hsa042700.11755999
162Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.11553958
163Protein digestion and absorption_Homo sapiens_hsa049740.11426060
164Cocaine addiction_Homo sapiens_hsa050300.11085097
165Endocytosis_Homo sapiens_hsa041440.10950394
166Tight junction_Homo sapiens_hsa045300.09515844
167Gastric acid secretion_Homo sapiens_hsa049710.08995271

Most similar genes based on co-expression Upload to Enrichr

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