BSG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
14-hydroxyproline metabolic process (GO:0019471)5.36788018
2COPI coating of Golgi vesicle (GO:0048205)5.27075004
3Golgi transport vesicle coating (GO:0048200)5.27075004
4proline biosynthetic process (GO:0006561)4.59393409
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.16794615
6peptidyl-proline hydroxylation (GO:0019511)4.06502901
7protein retention in ER lumen (GO:0006621)4.06324172
8protein hydroxylation (GO:0018126)4.03164881
9sarcomere organization (GO:0045214)3.95073326
10cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.89379771
11tricarboxylic acid cycle (GO:0006099)3.81880046
12positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.78719011
13negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.75404274
14glucose 6-phosphate metabolic process (GO:0051156)3.72117815
15protein localization to endosome (GO:0036010)3.62252912
16regulation of mammary gland epithelial cell proliferation (GO:0033599)3.62225895
17plasma membrane repair (GO:0001778)3.62161761
18lysine catabolic process (GO:0006554)3.60595492
19lysine metabolic process (GO:0006553)3.60595492
20glucose catabolic process (GO:0006007)3.54958596
21adherens junction assembly (GO:0034333)3.53203369
22barbed-end actin filament capping (GO:0051016)3.51486327
23bundle of His cell to Purkinje myocyte communication (GO:0086069)3.48804580
24cell communication by electrical coupling (GO:0010644)3.48156274
25planar cell polarity pathway involved in neural tube closure (GO:0090179)3.46543429
26protoporphyrinogen IX metabolic process (GO:0046501)3.45888193
27retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.43861463
28regulation of early endosome to late endosome transport (GO:2000641)3.43438406
29NADPH regeneration (GO:0006740)3.40769665
30focal adhesion assembly (GO:0048041)3.39302144
31cell-substrate adherens junction assembly (GO:0007045)3.39302144
32activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.34099738
33regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.31056122
34cell communication involved in cardiac conduction (GO:0086065)3.29134372
35cell-substrate junction assembly (GO:0007044)3.27205733
36apoptotic process involved in morphogenesis (GO:0060561)3.24126651
37negative regulation of cell size (GO:0045792)3.22137012
38tricarboxylic acid metabolic process (GO:0072350)3.21812657
39cardiac myofibril assembly (GO:0055003)3.21802207
40ventricular cardiac muscle cell action potential (GO:0086005)3.19477836
41proline metabolic process (GO:0006560)3.18402505
42positive regulation of nuclease activity (GO:0032075)3.17855816
43regulation of cholesterol homeostasis (GO:2000188)3.17204396
44negative regulation of potassium ion transmembrane transport (GO:1901380)3.13528359
45regulation of skeletal muscle contraction (GO:0014819)3.11139255
46regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.09366601
47epithelial cell-cell adhesion (GO:0090136)3.07144814
48activation of Rac GTPase activity (GO:0032863)3.06240727
49sodium ion export (GO:0071436)3.01065635
50peptidyl-arginine omega-N-methylation (GO:0035247)2.98580977
51regulation of translational fidelity (GO:0006450)2.96854357
52regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.93328454
53endoplasmic reticulum unfolded protein response (GO:0030968)2.92879664
54DNA unwinding involved in DNA replication (GO:0006268)2.92576406
552-oxoglutarate metabolic process (GO:0006103)2.92232694
56cellular protein complex localization (GO:0034629)2.91303768
57regulation of cholesterol biosynthetic process (GO:0045540)2.89920529
58nuclear envelope reassembly (GO:0031468)2.89055018
59mitotic nuclear envelope reassembly (GO:0007084)2.89055018
60regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.87419101
61NADH metabolic process (GO:0006734)2.87001894
62regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.86924128
63aspartate family amino acid catabolic process (GO:0009068)2.86460840
64regulation of fatty acid oxidation (GO:0046320)2.86418164
65desmosome organization (GO:0002934)2.86064287
66endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.85725032
67protein complex localization (GO:0031503)2.85386928
68negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.85247109
69regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.84648418
70carnitine shuttle (GO:0006853)2.84344733
71heart trabecula formation (GO:0060347)2.82457462
72cellular response to unfolded protein (GO:0034620)2.79346543
73regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.78980767
74regulation of fatty acid beta-oxidation (GO:0031998)2.78844697
75cardiac muscle contraction (GO:0060048)2.78801229
76regulation of nuclease activity (GO:0032069)2.78531036
77GDP-mannose metabolic process (GO:0019673)2.77915544
78pinocytosis (GO:0006907)2.75375300
79protoporphyrinogen IX biosynthetic process (GO:0006782)2.75024719
80monosaccharide biosynthetic process (GO:0046364)2.74335692
81ER-nucleus signaling pathway (GO:0006984)2.73917685
82skin morphogenesis (GO:0043589)2.72094815
83growth hormone secretion (GO:0030252)2.71227209
84gluconeogenesis (GO:0006094)2.68376504
85protein maturation by protein folding (GO:0022417)2.68284413
86stress fiber assembly (GO:0043149)2.67016041
87cytoskeletal anchoring at plasma membrane (GO:0007016)2.67000110
88cellular copper ion homeostasis (GO:0006878)2.66481880
89actomyosin structure organization (GO:0031032)2.65013846
903-UTR-mediated mRNA stabilization (GO:0070935)2.64926588
91positive regulation of triglyceride biosynthetic process (GO:0010867)2.64779389
92membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.64730735
93apoptotic cell clearance (GO:0043277)2.64531437
94cellular response to topologically incorrect protein (GO:0035967)2.63131618
95hemidesmosome assembly (GO:0031581)2.62610292
96membrane repolarization during action potential (GO:0086011)2.59351226
97fatty acid beta-oxidation (GO:0006635)2.59153683
98regulation of response to osmotic stress (GO:0047484)2.57324130
99positive regulation of glycogen biosynthetic process (GO:0045725)2.56307618
100mitotic chromosome condensation (GO:0007076)2.56261371
101fatty acid transmembrane transport (GO:1902001)2.55605683
102COPII vesicle coating (GO:0048208)2.54977901
103regulation of tight junction assembly (GO:2000810)2.54945636
104positive regulation of fatty acid beta-oxidation (GO:0032000)2.54734163
105modulation by virus of host morphology or physiology (GO:0019048)2.54714984
106glycolytic process (GO:0006096)2.54331436
107porphyrin-containing compound biosynthetic process (GO:0006779)2.54106210
108glutamine family amino acid biosynthetic process (GO:0009084)2.53841347
109modulation by symbiont of host cellular process (GO:0044068)2.52866431
110positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.52579840
111maternal placenta development (GO:0001893)2.52216402
112UV protection (GO:0009650)2.50618005
113galactose catabolic process (GO:0019388)2.50134056
114positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.49946329
115regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.47888553
116heme biosynthetic process (GO:0006783)2.47613712
117semaphorin-plexin signaling pathway (GO:0071526)2.47327289
118myofibril assembly (GO:0030239)2.47317286
119negative regulation of erythrocyte differentiation (GO:0045647)2.45074542
120vesicle coating (GO:0006901)2.44818816
121oxaloacetate metabolic process (GO:0006107)2.44412853
122regulation of cardioblast differentiation (GO:0051890)2.43943029
123positive regulation of fatty acid oxidation (GO:0046321)2.43696743
124endothelial cell morphogenesis (GO:0001886)2.43498553
125alpha-linolenic acid metabolic process (GO:0036109)2.42975246
126low-density lipoprotein particle clearance (GO:0034383)2.42260811
127hexose biosynthetic process (GO:0019319)2.41868682
128modulation by virus of host process (GO:0019054)2.41685808
129histone arginine methylation (GO:0034969)2.39967906
130vascular endothelial growth factor signaling pathway (GO:0038084)2.39880877
131mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.38972588
132actin-myosin filament sliding (GO:0033275)2.38660945
133muscle filament sliding (GO:0030049)2.38660945
134adenine nucleotide transport (GO:0051503)2.37966342
135regulation of secondary heart field cardioblast proliferation (GO:0003266)2.35693487
136regulation of cardioblast proliferation (GO:0003264)2.35693487
137L-serine transport (GO:0015825)2.34343215
138* protein targeting to plasma membrane (GO:0072661)2.34036609
139positive regulation of receptor recycling (GO:0001921)2.33839783
140regulation of glucose import in response to insulin stimulus (GO:2001273)2.33607103
141hemoglobin metabolic process (GO:0020027)2.33500321
142maintenance of protein localization in organelle (GO:0072595)2.33375542
143epithelial cell differentiation involved in prostate gland development (GO:0060742)2.33226532
144pentose-phosphate shunt (GO:0006098)2.33149640
145actin filament depolymerization (GO:0030042)2.33042600
146regulation of p38MAPK cascade (GO:1900744)2.32957850
147carnitine transmembrane transport (GO:1902603)2.31281778
148L-alpha-amino acid transmembrane transport (GO:1902475)2.31213613
149sulfur amino acid catabolic process (GO:0000098)2.30823431
150fatty acid oxidation (GO:0019395)2.30715284
151nucleobase-containing small molecule interconversion (GO:0015949)2.30442382
152cardiac muscle cell development (GO:0055013)2.30385347
153spliceosomal tri-snRNP complex assembly (GO:0000244)2.30193942
154toxin metabolic process (GO:0009404)2.30051459
155exocrine pancreas development (GO:0031017)2.28675197
156response to unfolded protein (GO:0006986)2.28527256
157amino-acid betaine transport (GO:0015838)2.27778762
158carnitine transport (GO:0015879)2.27778762
159basement membrane organization (GO:0071711)2.26785744
160positive regulation of triglyceride metabolic process (GO:0090208)2.25962183
161macroautophagy (GO:0016236)2.25782969
162lipid oxidation (GO:0034440)2.25195056
163cell migration involved in sprouting angiogenesis (GO:0002042)2.24923119
164carnitine metabolic process (GO:0009437)2.24890528

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.40257853
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.81688845
3* ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.69266713
4* RARG_19884340_ChIP-ChIP_MEFs_Mouse3.58232451
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.26279022
6ZNF263_19887448_ChIP-Seq_K562_Human3.02235513
7CLOCK_20551151_ChIP-Seq_293T_Human2.97926256
8* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.73048046
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.72324857
10* RXR_22158963_ChIP-Seq_LIVER_Mouse2.69497075
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.55814468
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.35040240
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.24382913
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.14228702
15E2F7_22180533_ChIP-Seq_HELA_Human2.11202224
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.02354464
17LXR_22292898_ChIP-Seq_THP-1_Human2.01750888
18VDR_21846776_ChIP-Seq_THP-1_Human2.01305999
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.93704017
20ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.90315727
21MYC_22102868_ChIP-Seq_BL_Human1.89435907
22RACK7_27058665_Chip-Seq_MCF-7_Human1.88300033
23ATF3_27146783_Chip-Seq_COLON_Human1.84270811
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.79376265
25CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.77778688
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.75688287
27TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.72557434
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.71223525
29KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.68709790
30ZFP281_18757296_ChIP-ChIP_E14_Mouse1.68634059
31TBX20_22328084_ChIP-Seq_HEART_Mouse1.68264953
32TBX20_22080862_ChIP-Seq_HEART_Mouse1.68264953
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.65994247
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.65689260
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.65182727
36DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.63421486
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.61051682
38NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.59348991
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59188348
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.58826895
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.55574506
42RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.52936945
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.51543029
44SRY_22984422_ChIP-ChIP_TESTIS_Rat1.49418339
45SOX2_27498859_Chip-Seq_STOMACH_Mouse1.48257026
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.47855006
47* TCF7_22412390_ChIP-Seq_EML_Mouse1.47842605
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46296136
49FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.46166833
50KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44244932
51CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.43319080
52SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.41817283
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40144037
54EP300_21415370_ChIP-Seq_HL-1_Mouse1.39520869
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.38288116
56UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38076208
57CTCF_27219007_Chip-Seq_ERYTHROID_Human1.37162414
58MYC_18358816_ChIP-ChIP_MESCs_Mouse1.36749525
59CREB1_26743006_Chip-Seq_LNCaP_Human1.35442886
60ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.35166210
61P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34924470
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34136829
63* KDM2B_26808549_Chip-Seq_K562_Human1.32965911
64CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.32242065
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.32158181
66MYC_19079543_ChIP-ChIP_MESCs_Mouse1.31654785
67ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.28626007
68SA1_27219007_Chip-Seq_ERYTHROID_Human1.28477255
69ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.28098618
70* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.27247360
71* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26430590
72* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25807921
73FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.24746664
74TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24628866
75* KDM2B_26808549_Chip-Seq_DND41_Human1.24547805
76EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23719698
77THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22802407
78EGR1_19374776_ChIP-ChIP_THP-1_Human1.21951277
79* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21538441
80GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.20397845
81* XRN2_22483619_ChIP-Seq_HELA_Human1.19547262
82P68_20966046_ChIP-Seq_HELA_Human1.19445268
83SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.19209773
84STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17332807
85* GATA1_19941826_ChIP-Seq_K562_Human1.16928615
86* NCOR1_26117541_ChIP-Seq_K562_Human1.16702436
87RUNX1_27514584_Chip-Seq_MCF-7_Human1.16636518
88ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16063723
89* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.15448583
90SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.15300845
91SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15102635
92GATA6_25053715_ChIP-Seq_YYC3_Human1.12466796
93ESR1_20079471_ChIP-ChIP_T-47D_Human1.10458810
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10069246
95* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09906801
96TP53_22127205_ChIP-Seq_IMR90_Human1.09688228
97PPAR_26484153_Chip-Seq_NCI-H1993_Human1.09390310
98* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09088301
99NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08924334
100* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08851274
101FOXO3_23340844_ChIP-Seq_DLD1_Human1.08622867
102WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08277288
103SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06583521
104OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06119379
105STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05795927
106MYC_19030024_ChIP-ChIP_MESCs_Mouse1.05788286
107ERG_21242973_ChIP-ChIP_JURKAT_Human1.05518203
108DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05498001
109HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04577414
110KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04043559
111TP63_22573176_ChIP-Seq_HFKS_Human1.03897988
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03555481
113* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.03269343
114PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.03157118
115ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.02809973
116DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01267582
117KDM2B_26808549_Chip-Seq_JURKAT_Human1.00027025
118FOXA2_19822575_ChIP-Seq_HepG2_Human0.99647109
119GATA4_25053715_ChIP-Seq_YYC3_Human0.99098381
120SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97494293
121TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.96953704
122MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.96672653
123ELF1_20517297_ChIP-Seq_JURKAT_Human0.95182679
124PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94880922
125AR_21909140_ChIP-Seq_LNCAP_Human0.94653766
126* SMC4_20622854_ChIP-Seq_HELA_Human0.94508819
127CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93875099
128* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93827150
129RARA_24833708_ChIP-Seq_LIVER_Mouse0.93320841
130BCOR_27268052_Chip-Seq_Bcells_Human0.93278748
131MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92645755
132SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92591399
133TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.92473490
134ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92445780
135CTCF_27219007_Chip-Seq_Bcells_Human0.91106223
136SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90219880
137ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89580668
138* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89353817
139STAT6_21828071_ChIP-Seq_BEAS2B_Human0.87842845
140TET1_21451524_ChIP-Seq_MESCs_Mouse0.87803933
141* UBF1/2_26484160_Chip-Seq_HMECs_Human0.86173315
142* SOX2_20726797_ChIP-Seq_SW620_Human0.86126514

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.45606336
2MP0002837_dystrophic_cardiac_calcinosis3.38599780
3MP0004084_abnormal_cardiac_muscle3.25680222
4MP0005451_abnormal_body_composition2.95121385
5MP0008260_abnormal_autophagy2.89870804
6MP0008438_abnormal_cutaneous_collagen2.59069035
7MP0002909_abnormal_adrenal_gland2.30171141
8MP0000751_myopathy2.30073148
9MP0000013_abnormal_adipose_tissue2.16571983
10MP0004233_abnormal_muscle_weight2.15649183
11MP0005257_abnormal_intraocular_pressure2.12164464
12MP0010234_abnormal_vibrissa_follicle2.09577837
13MP0004272_abnormal_basement_membrane2.09032714
14MP0004036_abnormal_muscle_relaxation2.09013987
15MP0003283_abnormal_digestive_organ2.06878709
16MP0004215_abnormal_myocardial_fiber2.05509230
17MP0005330_cardiomyopathy2.02065646
18MP0005076_abnormal_cell_differentiation1.96923211
19MP0009840_abnormal_foam_cell1.95161981
20MP0003646_muscle_fatigue1.87262821
21MP0003172_abnormal_lysosome_physiology1.86443349
22MP0002877_abnormal_melanocyte_morpholog1.85241375
23MP0008775_abnormal_heart_ventricle1.84945564
24MP0002269_muscular_atrophy1.79430907
25MP0002139_abnormal_hepatobiliary_system1.77938428
26MP0003566_abnormal_cell_adhesion1.77780309
27MP0004087_abnormal_muscle_fiber1.77631088
28MP0005083_abnormal_biliary_tract1.75772712
29MP0006054_spinal_hemorrhage1.74999377
30MP0005275_abnormal_skin_tensile1.73076381
31MP0002234_abnormal_pharynx_morphology1.72990700
32MP0004130_abnormal_muscle_cell1.71907747
33MP0000749_muscle_degeneration1.70606355
34MP0003453_abnormal_keratinocyte_physiol1.69840360
35MP0005623_abnormal_meninges_morphology1.67433382
36MP0005409_darkened_coat_color1.65219292
37MP0004043_abnormal_pH_regulation1.59925803
38MP0000003_abnormal_adipose_tissue1.59472835
39MP0000750_abnormal_muscle_regeneration1.57366779
40MP0002972_abnormal_cardiac_muscle1.55161934
41MP0009780_abnormal_chondrocyte_physiolo1.53613026
42MP0002060_abnormal_skin_morphology1.52957022
43MP0010630_abnormal_cardiac_muscle1.52076740
44MP0003123_paternal_imprinting1.51012971
45MP0000566_synostosis1.50707164
46MP0005167_abnormal_blood-brain_barrier1.48615884
47MP0005670_abnormal_white_adipose1.48495183
48MP0010368_abnormal_lymphatic_system1.48027992
49MP0003279_aneurysm1.47670708
50MP0006138_congestive_heart_failure1.45667152
51MP0003806_abnormal_nucleotide_metabolis1.43773179
52MP0005360_urolithiasis1.43147244
53MP0000678_abnormal_parathyroid_gland1.41938564
54MP0000579_abnormal_nail_morphology1.41556819
55MP0005365_abnormal_bile_salt1.40343987
56MP0005501_abnormal_skin_physiology1.40285312
57MP0001544_abnormal_cardiovascular_syste1.38647723
58MP0005385_cardiovascular_system_phenoty1.38647723
59MP0000858_altered_metastatic_potential1.37502800
60MP0009672_abnormal_birth_weight1.37205981
61MP0005085_abnormal_gallbladder_physiolo1.36273639
62MP0005666_abnormal_adipose_tissue1.35751243
63MP0005375_adipose_tissue_phenotype1.35197020
64MP0005620_abnormal_muscle_contractility1.34766994
65MP0004858_abnormal_nervous_system1.34386684
66MP0010352_gastrointestinal_tract_polyps1.34240283
67MP0003111_abnormal_nucleus_morphology1.33850729
68MP0009278_abnormal_bone_marrow1.33424906
69MP0001730_embryonic_growth_arrest1.32161940
70MP0002796_impaired_skin_barrier1.30449184
71MP0000747_muscle_weakness1.29562491
72MP0009384_cardiac_valve_regurgitation1.25331837
73MP0003252_abnormal_bile_duct1.23047643
74MP0003300_gastrointestinal_ulcer1.21005319
75MP0010329_abnormal_lipoprotein_level1.18720585
76MP0001915_intracranial_hemorrhage1.15897596
77MP0008961_abnormal_basal_metabolism1.15075477
78MP0002896_abnormal_bone_mineralization1.14028607
79MP0000759_abnormal_skeletal_muscle1.12160696
80MP0004484_altered_response_of1.12117583
81MP0001958_emphysema1.11946100
82MP0003091_abnormal_cell_migration1.11627498
83MP0010030_abnormal_orbit_morphology1.10612127
84MP0001849_ear_inflammation1.08374229
85MP0000537_abnormal_urethra_morphology1.07869305
86MP0001348_abnormal_lacrimal_gland1.06663000
87MP0009643_abnormal_urine_homeostasis1.06237036
88MP0003634_abnormal_glial_cell1.06175462
89MP0004264_abnormal_extraembryonic_tissu1.02586451
90MP0001666_abnormal_nutrient_absorption1.02026393
91MP0005621_abnormal_cell_physiology1.01910829
92MP0002106_abnormal_muscle_physiology1.01666537
93MP0003656_abnormal_erythrocyte_physiolo0.99944863
94* MP0002080_prenatal_lethality0.99813124
95MP0004859_abnormal_synaptic_plasticity0.99416768
96MP0002249_abnormal_larynx_morphology0.98949360
97MP0001756_abnormal_urination0.98677018
98MP0003137_abnormal_impulse_conducting0.98308499
99MP0003195_calcinosis0.98211039
100MP0002089_abnormal_postnatal_growth/wei0.98104141
101MP0008875_abnormal_xenobiotic_pharmacok0.97589165
102MP0003221_abnormal_cardiomyocyte_apopto0.97421979
103MP0003075_altered_response_to0.97340178
104MP0004147_increased_porphyrin_level0.95572225
105MP0004085_abnormal_heartbeat0.95494858
106MP0008932_abnormal_embryonic_tissue0.95108714
107MP0004957_abnormal_blastocyst_morpholog0.95002575
108MP0003191_abnormal_cellular_cholesterol0.94159357
109MP0005332_abnormal_amino_acid0.92805858
110MP0000467_abnormal_esophagus_morphology0.92793408
111MP0000762_abnormal_tongue_morphology0.92417560
112MP0005023_abnormal_wound_healing0.92341884
113MP0000534_abnormal_ureter_morphology0.91498342
114MP0005369_muscle_phenotype0.90824318
115MP0005220_abnormal_exocrine_pancreas0.90696186
116MP0004185_abnormal_adipocyte_glucose0.88895923
117MP0005319_abnormal_enzyme/_coenzyme0.87795874
118MP0002078_abnormal_glucose_homeostasis0.87759574
119MP0002090_abnormal_vision0.87518221
120MP0005165_increased_susceptibility_to0.86126747
121MP0001661_extended_life_span0.84792034
122MP0005503_abnormal_tendon_morphology0.84680982
123MP0000266_abnormal_heart_morphology0.84034967
124MP0004510_myositis0.83896658
125MP0003984_embryonic_growth_retardation0.83863484
126MP0000350_abnormal_cell_proliferation0.83154255
127MP0003329_amyloid_beta_deposits0.83060953
128MP0004145_abnormal_muscle_electrophysio0.81867501
129MP0002254_reproductive_system_inflammat0.80903579
130MP0005380_embryogenesis_phenotype0.80507041
131MP0001672_abnormal_embryogenesis/_devel0.80507041
132MP0001944_abnormal_pancreas_morphology0.80494349
133MP0003115_abnormal_respiratory_system0.80492937
134MP0002118_abnormal_lipid_homeostasis0.80193410
135MP0005384_cellular_phenotype0.79806861
136MP0009931_abnormal_skin_appearance0.78732381
137MP0002108_abnormal_muscle_morphology0.78606974
138MP0000604_amyloidosis0.77641057
139MP0005248_abnormal_Harderian_gland0.75559311
140MP0004019_abnormal_vitamin_homeostasis0.74794142
141MP0002088_abnormal_embryonic_growth/wei0.74781355
142MP0005508_abnormal_skeleton_morphology0.74383721
143MP0003045_fibrosis0.74060249
144MP0005058_abnormal_lysosome_morphology0.73915437
145MP0000733_abnormal_muscle_development0.73890444
146MP0000462_abnormal_digestive_system0.73756538
147MP0002086_abnormal_extraembryonic_tissu0.73382400
148MP0005187_abnormal_penis_morphology0.72260889
149MP0000490_abnormal_crypts_of0.71978892
150MP0000681_abnormal_thyroid_gland0.71062156
151MP0005171_absent_coat_pigmentation0.70144909
152MP0009053_abnormal_anal_canal0.68661161
153MP0003385_abnormal_body_wall0.67288408
154MP0010771_integument_phenotype0.66380038
155MP0001216_abnormal_epidermal_layer0.65555067
156MP0001346_abnormal_lacrimal_gland0.64695394
157MP0003942_abnormal_urinary_system0.64508746

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)4.32617477
2Hypoglycemic coma (HP:0001325)4.14032809
3Right ventricular cardiomyopathy (HP:0011663)4.06568848
4Myoglobinuria (HP:0002913)3.99884627
5Vertebral compression fractures (HP:0002953)3.77139093
6Sudden death (HP:0001699)3.52301692
7Protrusio acetabuli (HP:0003179)3.44931465
8Ketoacidosis (HP:0001993)3.34218121
9Distal lower limb muscle weakness (HP:0009053)3.19044089
10Ventricular tachycardia (HP:0004756)3.18249792
11Hyperinsulinemic hypoglycemia (HP:0000825)3.17242018
12Hyperacusis (HP:0010780)3.16083204
13Insomnia (HP:0100785)3.08224571
14Asymmetric septal hypertrophy (HP:0001670)2.95512208
15Distal lower limb amyotrophy (HP:0008944)2.89934376
16Cerebral aneurysm (HP:0004944)2.85028149
17Palpitations (HP:0001962)2.84615779
18Ventricular fibrillation (HP:0001663)2.79265752
19Hypoglycemic seizures (HP:0002173)2.78342773
20Bundle branch block (HP:0011710)2.77970258
21Exercise-induced myalgia (HP:0003738)2.76934874
22Increased connective tissue (HP:0009025)2.72766394
23Premature rupture of membranes (HP:0001788)2.71115658
24Rhabdomyolysis (HP:0003201)2.70966761
25Gout (HP:0001997)2.70461738
26Ulnar bowing (HP:0003031)2.68662394
27Centrally nucleated skeletal muscle fibers (HP:0003687)2.66254107
28Broad metatarsal (HP:0001783)2.63781336
29Muscle fiber splitting (HP:0003555)2.61454617
30Hand muscle atrophy (HP:0009130)2.56169044
31Ketosis (HP:0001946)2.55882975
32Distal upper limb amyotrophy (HP:0007149)2.54989833
33Upper limb amyotrophy (HP:0009129)2.54989833
34Difficulty climbing stairs (HP:0003551)2.54722518
35Syncope (HP:0001279)2.49237782
36Hyporeflexia of lower limbs (HP:0002600)2.46530629
37Ventricular arrhythmia (HP:0004308)2.45075302
38Hypercortisolism (HP:0001578)2.38251880
39Polycythemia (HP:0001901)2.37965071
40Atrial fibrillation (HP:0005110)2.37735115
41Cerebral inclusion bodies (HP:0100314)2.37044009
42Aneurysm (HP:0002617)2.36040858
43Late onset (HP:0003584)2.30414717
44Lower limb amyotrophy (HP:0007210)2.29274702
45Lymphangioma (HP:0100764)2.27844041
46Mildly elevated creatine phosphokinase (HP:0008180)2.27509064
47Abnormal gallbladder physiology (HP:0012438)2.27317156
48Cholecystitis (HP:0001082)2.27317156
49Enlarged penis (HP:0000040)2.27302545
50Shallow orbits (HP:0000586)2.25074189
51Lipoatrophy (HP:0100578)2.24971532
52Primary atrial arrhythmia (HP:0001692)2.21684859
53Prolonged QT interval (HP:0001657)2.20808037
54Hyperglycemia (HP:0003074)2.20748458
55Supraventricular arrhythmia (HP:0005115)2.16132732
56Cervical subluxation (HP:0003308)2.15733518
57Long toe (HP:0010511)2.15534853
58Reticulocytosis (HP:0001923)2.14733658
59Ankle contracture (HP:0006466)2.12962509
60Long palpebral fissure (HP:0000637)2.12585614
61Supraventricular tachycardia (HP:0004755)2.12473629
62Neurofibrillary tangles (HP:0002185)2.12245186
63Limb-girdle muscle atrophy (HP:0003797)2.12031925
64Hypoalphalipoproteinemia (HP:0003233)2.11967491
65Atrophic scars (HP:0001075)2.10307020
66Ragged-red muscle fibers (HP:0003200)2.10184195
67Broad face (HP:0000283)2.09978666
68Cholelithiasis (HP:0001081)2.09564298
69Myopathic facies (HP:0002058)2.08951625
70Trismus (HP:0000211)2.08573048
71Wormian bones (HP:0002645)2.08258038
72Muscle stiffness (HP:0003552)2.07754193
73Type 1 muscle fiber predominance (HP:0003803)2.07568012
74Difficulty running (HP:0009046)2.05072577
75Pancreatic islet-cell hyperplasia (HP:0004510)2.04639342
76Osteolytic defects of the hand bones (HP:0009699)2.04441326
77Osteolytic defects of the phalanges of the hand (HP:0009771)2.04441326
78Abnormality of skeletal muscle fiber size (HP:0012084)2.02738567
79Xanthomatosis (HP:0000991)2.02286399
80Disproportionate tall stature (HP:0001519)2.02003849
81Central scotoma (HP:0000603)2.00754475
82Biconcave vertebral bodies (HP:0004586)1.99260351
83Hyperammonemia (HP:0001987)1.98492164
84Diaphragmatic weakness (HP:0009113)1.98458075
85Abnormal atrioventricular conduction (HP:0005150)1.98358103
86Abnormality of the pancreatic islet cells (HP:0006476)1.98258725
87Abnormality of endocrine pancreas physiology (HP:0012093)1.98258725
88Abnormality of the calf musculature (HP:0001430)1.98229311
89Dilated cardiomyopathy (HP:0001644)1.97430001
90Short nail (HP:0001799)1.96655965
91Flat acetabular roof (HP:0003180)1.96650649
92Elbow flexion contracture (HP:0002987)1.94391822
93Heart block (HP:0012722)1.94059297
94Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.93797923
95EMG: myopathic abnormalities (HP:0003458)1.93668137
96Generalized amyotrophy (HP:0003700)1.93161856
97Abnormal gallbladder morphology (HP:0012437)1.92591513
98Abnormality of fatty-acid metabolism (HP:0004359)1.91751252
99Increased variability in muscle fiber diameter (HP:0003557)1.91162536
100Supranuclear gaze palsy (HP:0000605)1.90720696
101Nuclear cataract (HP:0100018)1.89219532
102Atrioventricular block (HP:0001678)1.88446641
103Back pain (HP:0003418)1.87990766
104Fragile skin (HP:0001030)1.87639154
105Abnormality of dentin (HP:0010299)1.86626720
106Deep venous thrombosis (HP:0002625)1.86171770
107Skin nodule (HP:0200036)1.85499731
108Blue sclerae (HP:0000592)1.85466952
109Abnormality of liposaccharide metabolism (HP:0010968)1.85438082
110Abnormality of glycosphingolipid metabolism (HP:0004343)1.85438082
111Abnormality of glycolipid metabolism (HP:0010969)1.85438082
112Aortic aneurysm (HP:0004942)1.84615435
113J-shaped sella turcica (HP:0002680)1.83522820
114Hemorrhage of the eye (HP:0011885)1.81532744
115Spinal rigidity (HP:0003306)1.81313637
116Abnormality of the gallbladder (HP:0005264)1.80823391
117Advanced eruption of teeth (HP:0006288)1.80722147
118Abnormality of reticulocytes (HP:0004312)1.80404952
119Abnormality of the distal phalanges of the toes (HP:0010182)1.79879609
120Symptomatic seizures (HP:0011145)1.79741292
121Bladder diverticulum (HP:0000015)1.78283195
122Turricephaly (HP:0000262)1.78254768
123Hyperparathyroidism (HP:0000843)1.77524952
124Insulin resistance (HP:0000855)1.76087528
125Renal duplication (HP:0000075)1.75291236
126Abnormal cartilage morphology (HP:0002763)1.74376312
127Axonal loss (HP:0003447)1.74191872
128Natal tooth (HP:0000695)1.73325438
129Urinary glycosaminoglycan excretion (HP:0003541)1.73063263
130Mucopolysacchariduria (HP:0008155)1.73063263
131Myotonia (HP:0002486)1.73051328
132Premature skin wrinkling (HP:0100678)1.73034310
133Progressive muscle weakness (HP:0003323)1.72679703
134Overriding aorta (HP:0002623)1.72602628
135Mitral regurgitation (HP:0001653)1.72307887
136Increased purine levels (HP:0004368)1.72275443
137Hyperuricemia (HP:0002149)1.72275443
138Abnormality of glycolysis (HP:0004366)1.72272990
139Selective tooth agenesis (HP:0001592)1.71991881
140Global brain atrophy (HP:0002283)1.71936799
141Calf muscle hypertrophy (HP:0008981)1.71735241
142Abnormality of monocarboxylic acid metabolism (HP:0010996)1.71715969
143Insulin-resistant diabetes mellitus (HP:0000831)1.71215111
144Dysostosis multiplex (HP:0000943)1.70996731
145Abnormality of the thoracic spine (HP:0100711)1.69514830
146Retinal atrophy (HP:0001105)1.69485750
147Abnormality of the left ventricular outflow tract (HP:0011103)1.69274817
148Subaortic stenosis (HP:0001682)1.69274817
149Foot dorsiflexor weakness (HP:0009027)1.68147552
150Stridor (HP:0010307)1.67379314
151Esophageal varix (HP:0002040)1.66904315
152Abnormality of the Achilles tendon (HP:0005109)1.66062299
153Broad distal phalanx of finger (HP:0009836)1.66001869
154Abnormality of the heme biosynthetic pathway (HP:0010472)1.65787456
155Achilles tendon contracture (HP:0001771)1.65660237
156Abnormality of the tricuspid valve (HP:0001702)1.65504996
157Neonatal death (HP:0003811)1.62464357
158Ankyloglossia (HP:0010296)1.59664118
159Bronchomalacia (HP:0002780)1.59662651
160Arnold-Chiari malformation (HP:0002308)1.58281911
161Obstructive sleep apnea (HP:0002870)1.58210534
162Growth hormone excess (HP:0000845)1.57709601
163Hypoplasia of the capital femoral epiphysis (HP:0003090)1.55849627
164Asymmetry of the thorax (HP:0001555)1.54622507
165Abnormality of the acetabulum (HP:0003170)1.54501552
166Abnormality of oral frenula (HP:0000190)1.54147323
167Abnormality of the umbilical cord (HP:0010881)1.52229628

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.59231233
2PKN24.22992543
3SMG13.53259921
4EPHA22.92445139
5TTN2.77764101
6PRPF4B2.71752799
7LMTK22.65282640
8ERN12.60667231
9NEK12.59915056
10NME22.41847504
11RIPK12.34954560
12BCKDK2.22063989
13TESK22.10151038
14IRAK32.00662064
15PDGFRA1.95511316
16PDK41.86474883
17PDK31.86474883
18SIK11.86109423
19TAOK21.84789379
20PTK61.84757202
21ARAF1.81349695
22SCYL21.75046636
23CDK121.74472822
24TESK11.67998768
25FLT31.65811151
26DDR21.65722695
27PTK21.59425066
28PHKG11.58238188
29PHKG21.58238188
30PRKD31.52131926
31EEF2K1.50940679
32FER1.44003933
33PAK31.40998995
34WNK41.37082707
35KSR21.36874330
36PAK41.33796193
37INSRR1.21688733
38EIF2AK11.19261145
39LRRK21.18037768
40MAPKAPK31.17242945
41VRK21.16395468
42KDR1.15543382
43PIM21.11150782
44EPHB21.09300465
45MYLK1.07497583
46PDK21.06742814
47MET1.06425018
48DMPK1.04495039
49BMX1.03658409
50MAP2K11.03354269
51MAP3K91.00948406
52FRK0.99456160
53MAP3K20.99044253
54LATS20.98222378
55BRAF0.98035148
56TAOK10.97906026
57MST1R0.97843019
58MAP2K20.96621042
59RET0.94475748
60MAPK150.91300283
61NTRK10.90756984
62LATS10.89832280
63MAP3K30.89666364
64WNK30.89577096
65CAMKK10.87587690
66ILK0.85552530
67STK380.85053911
68DYRK1B0.84970961
69PRKG20.83954014
70TIE10.82372284
71BUB10.81572668
72MAP3K100.81170391
73MTOR0.79058227
74PAK60.76653547
75MAP3K10.75192006
76FGFR10.73447192
77TGFBR20.73441587
78BRSK10.72430839
79FGFR40.70512678
80OBSCN0.70406269
81PAK20.70394717
82PRKD10.69454769
83DAPK30.68935781
84RPS6KA20.68524490
85STK38L0.68109292
86MAP3K110.66919472
87CDK70.66847916
88DAPK10.66796114
89CDC42BPA0.65632295
90PIK3CG0.63802271
91PRKD20.63441302
92ICK0.62967386
93MAP2K30.61871483
94ROCK10.60741769
95PASK0.60344703
96CDK11A0.58285382
97LIMK10.57717450
98CDK150.57610511
99RPS6KB20.57509065
100MARK20.56386933
101PIK3CA0.56231240
102MAP3K60.54040928
103STK40.53897789
104ABL20.52836289
105PRKAA10.52346731
106MAP3K70.52292512
107PBK0.52145262
108CDK180.51665631
109MAPK110.51411428
110CAMKK20.50672098
111PAK10.48886979
112AURKA0.48020018
113CDK140.47481160
114AKT20.47259724
115MOS0.46755507
116ERBB20.46375410
117PTK2B0.45806889
118RPS6KC10.45460126
119RPS6KL10.45460126
120HIPK20.45437417
121MAP3K130.44346217
122DAPK20.43429575
123CAMK1D0.42157234
124ALK0.41967960
125TYRO30.41614296
126TTK0.41157166
127PINK10.40606777
128PDPK10.40578229
129ROCK20.40294060
130EPHA30.40089936
131MAP3K80.40019332
132CLK10.39632485
133EPHB10.39149133
134RAF10.38200832
135CAMK2G0.37913515
136PDGFRB0.37695361
137CAMK2D0.36775624
138CDK60.36149311
139CDK40.36131658
140PRKCH0.35109369
141UHMK10.33626114
142NEK90.33625423
143WNK10.32999044
144TBK10.32860330
145KSR10.30686092

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.87830392
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.10829916
3Other glycan degradation_Homo sapiens_hsa005112.58133404
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.47184231
5Fatty acid degradation_Homo sapiens_hsa000712.45152437
6Carbon metabolism_Homo sapiens_hsa012002.16420624
7Nitrogen metabolism_Homo sapiens_hsa009102.14459262
8Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.12919638
9Propanoate metabolism_Homo sapiens_hsa006401.86864859
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83116229
11Biosynthesis of amino acids_Homo sapiens_hsa012301.75652394
12Arginine biosynthesis_Homo sapiens_hsa002201.72174338
13Cyanoamino acid metabolism_Homo sapiens_hsa004601.71897815
14Fatty acid metabolism_Homo sapiens_hsa012121.70151682
15Dilated cardiomyopathy_Homo sapiens_hsa054141.70016998
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.69649434
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.67639541
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.66589917
19Pyruvate metabolism_Homo sapiens_hsa006201.65443190
20Bile secretion_Homo sapiens_hsa049761.60667701
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.58959625
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.58081949
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.55063202
24Galactose metabolism_Homo sapiens_hsa000521.48693321
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.47678117
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.44463692
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.39345588
28Fructose and mannose metabolism_Homo sapiens_hsa000511.37195889
29Cardiac muscle contraction_Homo sapiens_hsa042601.34972966
30PPAR signaling pathway_Homo sapiens_hsa033201.34240447
31Tryptophan metabolism_Homo sapiens_hsa003801.30395934
32Starch and sucrose metabolism_Homo sapiens_hsa005001.29903994
33Fat digestion and absorption_Homo sapiens_hsa049751.25566685
34Butanoate metabolism_Homo sapiens_hsa006501.25114431
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22616621
36Glucagon signaling pathway_Homo sapiens_hsa049221.20179468
37Vitamin B6 metabolism_Homo sapiens_hsa007501.19890733
38Bladder cancer_Homo sapiens_hsa052191.19384273
39Non-small cell lung cancer_Homo sapiens_hsa052231.15929871
40Notch signaling pathway_Homo sapiens_hsa043301.15206833
41Sulfur metabolism_Homo sapiens_hsa009201.08923773
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08088156
43Endometrial cancer_Homo sapiens_hsa052131.06658992
44Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.06460021
45ECM-receptor interaction_Homo sapiens_hsa045121.06320921
46Insulin resistance_Homo sapiens_hsa049311.06189029
47Synaptic vesicle cycle_Homo sapiens_hsa047211.05274273
48Selenocompound metabolism_Homo sapiens_hsa004501.04851975
49DNA replication_Homo sapiens_hsa030301.04034261
50Insulin secretion_Homo sapiens_hsa049111.03800957
51Fatty acid elongation_Homo sapiens_hsa000621.03284057
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03058414
53Pancreatic cancer_Homo sapiens_hsa052121.01622291
54Focal adhesion_Homo sapiens_hsa045101.00173637
55VEGF signaling pathway_Homo sapiens_hsa043700.99772752
56Acute myeloid leukemia_Homo sapiens_hsa052210.99208538
57Phenylalanine metabolism_Homo sapiens_hsa003600.97561857
58Glioma_Homo sapiens_hsa052140.94993677
59Protein digestion and absorption_Homo sapiens_hsa049740.94432523
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91779972
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.90326126
62Pentose phosphate pathway_Homo sapiens_hsa000300.89350890
63Insulin signaling pathway_Homo sapiens_hsa049100.87363619
64AMPK signaling pathway_Homo sapiens_hsa041520.86935715
65Adherens junction_Homo sapiens_hsa045200.86511083
66HIF-1 signaling pathway_Homo sapiens_hsa040660.85625990
67Tight junction_Homo sapiens_hsa045300.84397214
68Arginine and proline metabolism_Homo sapiens_hsa003300.83954891
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80713442
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79614300
71Thyroid hormone synthesis_Homo sapiens_hsa049180.79210828
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78767353
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.78379205
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.76622943
75beta-Alanine metabolism_Homo sapiens_hsa004100.75559065
76Type II diabetes mellitus_Homo sapiens_hsa049300.72280761
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70984157
78Proteoglycans in cancer_Homo sapiens_hsa052050.70307760
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69247124
80ErbB signaling pathway_Homo sapiens_hsa040120.69179743
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68945537
82Endocytosis_Homo sapiens_hsa041440.68745744
83Base excision repair_Homo sapiens_hsa034100.68624222
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68304354
85Vibrio cholerae infection_Homo sapiens_hsa051100.67659125
86Lysine degradation_Homo sapiens_hsa003100.67597458
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65621789
88mTOR signaling pathway_Homo sapiens_hsa041500.65582210
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.65146578
90Amoebiasis_Homo sapiens_hsa051460.64256985
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64191756
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64189389
93Tyrosine metabolism_Homo sapiens_hsa003500.63254427
94Folate biosynthesis_Homo sapiens_hsa007900.63069888
95Lysosome_Homo sapiens_hsa041420.61636449
96Apoptosis_Homo sapiens_hsa042100.60785337
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.60530116
98N-Glycan biosynthesis_Homo sapiens_hsa005100.59784396
99Mineral absorption_Homo sapiens_hsa049780.58294408
100Chemical carcinogenesis_Homo sapiens_hsa052040.58061352
101Shigellosis_Homo sapiens_hsa051310.57777849
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57638652
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.55538031
104MicroRNAs in cancer_Homo sapiens_hsa052060.54626021
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54592396
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.54570462
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54277661
108Glutathione metabolism_Homo sapiens_hsa004800.53611094
109Gastric acid secretion_Homo sapiens_hsa049710.53226666
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51734380
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51560986
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51515267
113Estrogen signaling pathway_Homo sapiens_hsa049150.51339940
114Thyroid cancer_Homo sapiens_hsa052160.51092080
115Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50999882
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50814674
117GnRH signaling pathway_Homo sapiens_hsa049120.49975283
118Peroxisome_Homo sapiens_hsa041460.49687198
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49654367
120Prion diseases_Homo sapiens_hsa050200.49622567
121Pancreatic secretion_Homo sapiens_hsa049720.49519815
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48427992
123Hippo signaling pathway_Homo sapiens_hsa043900.48395560
124Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47931870
125Melanogenesis_Homo sapiens_hsa049160.47402288
126Glycerolipid metabolism_Homo sapiens_hsa005610.46405497
127Cell cycle_Homo sapiens_hsa041100.44145482
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43566807
129Salmonella infection_Homo sapiens_hsa051320.42225436
130Small cell lung cancer_Homo sapiens_hsa052220.41430415
131Long-term potentiation_Homo sapiens_hsa047200.41343818
132Prostate cancer_Homo sapiens_hsa052150.40230546
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.39479338
134Inositol phosphate metabolism_Homo sapiens_hsa005620.39437732
135Sulfur relay system_Homo sapiens_hsa041220.39221459
136Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38443555
137Renal cell carcinoma_Homo sapiens_hsa052110.38107761
138Complement and coagulation cascades_Homo sapiens_hsa046100.36273118
139Chronic myeloid leukemia_Homo sapiens_hsa052200.36211385

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