BST2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.10541031
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.10541031
3L-phenylalanine catabolic process (GO:0006559)4.67134682
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.67134682
5immunoglobulin mediated immune response (GO:0016064)4.65401487
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.63182297
7L-phenylalanine metabolic process (GO:0006558)4.63182297
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.61313859
9antigen processing and presentation of endogenous antigen (GO:0019883)4.45795137
10complement activation, alternative pathway (GO:0006957)4.42802995
11aromatic amino acid family catabolic process (GO:0009074)4.41057629
12negative regulation of fibrinolysis (GO:0051918)4.22972437
13peptidyl-glutamic acid carboxylation (GO:0017187)4.21905776
14protein carboxylation (GO:0018214)4.21905776
15kynurenine metabolic process (GO:0070189)4.19465078
16indole-containing compound catabolic process (GO:0042436)4.19211261
17indolalkylamine catabolic process (GO:0046218)4.19211261
18tryptophan catabolic process (GO:0006569)4.19211261
19regulation of protein activation cascade (GO:2000257)4.13784028
20high-density lipoprotein particle remodeling (GO:0034375)4.03611054
21bile acid biosynthetic process (GO:0006699)3.98199411
22positive regulation of gamma-delta T cell activation (GO:0046645)3.96260435
23regulation of complement activation (GO:0030449)3.96121561
24alpha-linolenic acid metabolic process (GO:0036109)3.95779605
25urea metabolic process (GO:0019627)3.95004942
26urea cycle (GO:0000050)3.95004942
27tryptophan metabolic process (GO:0006568)3.93237809
28regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.91883096
29plasma lipoprotein particle clearance (GO:0034381)3.91697957
30regulation of fibrinolysis (GO:0051917)3.85436656
31* response to interferon-beta (GO:0035456)3.82819725
32B cell mediated immunity (GO:0019724)3.71749427
33glyoxylate metabolic process (GO:0046487)3.69867847
34sulfur amino acid catabolic process (GO:0000098)3.68917584
35nitrogen cycle metabolic process (GO:0071941)3.64644662
36interferon-gamma-mediated signaling pathway (GO:0060333)3.63224388
37reverse cholesterol transport (GO:0043691)3.59011413
38phospholipid efflux (GO:0033700)3.54586039
39regulation of cholesterol esterification (GO:0010872)3.53511463
40cysteine metabolic process (GO:0006534)3.53407334
41positive regulation of interferon-alpha production (GO:0032727)3.52418782
42positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.49491702
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.49144090
44regulation of triglyceride catabolic process (GO:0010896)3.46187055
45protein-lipid complex remodeling (GO:0034368)3.46140606
46macromolecular complex remodeling (GO:0034367)3.46140606
47plasma lipoprotein particle remodeling (GO:0034369)3.46140606
48NIK/NF-kappaB signaling (GO:0038061)3.44023043
49response to peptidoglycan (GO:0032494)3.41054437
50negative regulation of cell killing (GO:0031342)3.37170272
51negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.37170272
52response to type I interferon (GO:0034340)3.35082206
53type I interferon signaling pathway (GO:0060337)3.34790352
54cellular response to type I interferon (GO:0071357)3.34790352
55negative regulation of cholesterol transport (GO:0032375)3.34288130
56negative regulation of sterol transport (GO:0032372)3.34288130
57aldehyde catabolic process (GO:0046185)3.32554637
58positive regulation of antigen processing and presentation (GO:0002579)3.31830208
59* negative regulation of viral genome replication (GO:0045071)3.31401354
60regulation of interferon-alpha production (GO:0032647)3.30671139
61cellular response to interferon-beta (GO:0035458)3.29878655
62bile acid metabolic process (GO:0008206)3.28958269
63regulation of antigen processing and presentation (GO:0002577)3.28591207
64positive regulation of B cell differentiation (GO:0045579)3.28385928
65T cell migration (GO:0072678)3.26533877
66neutrophil activation involved in immune response (GO:0002283)3.22730137
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.22372040
68low-density lipoprotein particle clearance (GO:0034383)3.21453018
69detection of bacterium (GO:0016045)3.21312591
70homocysteine metabolic process (GO:0050667)3.20810514
71positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.16842672
72cholesterol efflux (GO:0033344)3.16644446
73serine family amino acid catabolic process (GO:0009071)3.16472465
74aromatic amino acid family metabolic process (GO:0009072)3.15428756
75positive regulation of lipoprotein lipase activity (GO:0051006)3.13444152
76positive regulation of triglyceride lipase activity (GO:0061365)3.13444152
77acute-phase response (GO:0006953)3.11323096
78complement activation (GO:0006956)3.09519789
79triglyceride homeostasis (GO:0070328)3.09300393
80acylglycerol homeostasis (GO:0055090)3.09300393
81detection of other organism (GO:0098543)3.08736811
82fibrinolysis (GO:0042730)3.08681899
83negative regulation of interleukin-12 production (GO:0032695)3.08233949
84lipopolysaccharide-mediated signaling pathway (GO:0031663)3.06515790
85mature B cell differentiation involved in immune response (GO:0002313)3.06249565
86regulation of cholesterol storage (GO:0010885)3.05809172
87complement activation, classical pathway (GO:0006958)3.05575723
88glycine metabolic process (GO:0006544)3.04363340
89negative regulation of myeloid cell apoptotic process (GO:0033033)3.04331140
90cellular response to interferon-gamma (GO:0071346)3.03867663
91nicotinamide nucleotide biosynthetic process (GO:0019359)3.03309426
92pyridine nucleotide biosynthetic process (GO:0019363)3.03309426
93arginine metabolic process (GO:0006525)3.02846920
94protein activation cascade (GO:0072376)3.02629816
95amino-acid betaine metabolic process (GO:0006577)3.02469070
96ethanol oxidation (GO:0006069)2.99865452
97lymphocyte chemotaxis (GO:0048247)2.99348923
98plasma lipoprotein particle assembly (GO:0034377)2.98940857
99myeloid dendritic cell activation (GO:0001773)2.97735767
100T-helper 1 type immune response (GO:0042088)2.97212878
101tyrosine metabolic process (GO:0006570)2.97143896
102myeloid dendritic cell differentiation (GO:0043011)2.96589045
103NAD biosynthetic process (GO:0009435)2.96467819
104Arp2/3 complex-mediated actin nucleation (GO:0034314)2.94602155
105lysine metabolic process (GO:0006553)2.93202605
106lysine catabolic process (GO:0006554)2.93202605
107positive regulation of coagulation (GO:0050820)2.87631989
108regulation of dendritic cell antigen processing and presentation (GO:0002604)2.87024660
109imidazole-containing compound metabolic process (GO:0052803)2.86985334
110regulation of humoral immune response (GO:0002920)2.86785681
111regulation of B cell receptor signaling pathway (GO:0050855)2.86400092
112low-density lipoprotein particle remodeling (GO:0034374)2.86297386
113cofactor catabolic process (GO:0051187)2.85776366
114positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.85338611
115alpha-amino acid catabolic process (GO:1901606)2.85089628
116regulation of interferon-beta biosynthetic process (GO:0045357)2.84948160
117regulation of gamma-delta T cell activation (GO:0046643)2.84379947
118cholesterol homeostasis (GO:0042632)2.84360857
119pinocytosis (GO:0006907)2.83545588
120positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.82706423
121bile acid and bile salt transport (GO:0015721)2.82477845
122* response to interferon-gamma (GO:0034341)2.82128981
123positive regulation of hemostasis (GO:1900048)2.81313948
124positive regulation of blood coagulation (GO:0030194)2.81313948
125benzene-containing compound metabolic process (GO:0042537)2.80813818
126blood coagulation, intrinsic pathway (GO:0007597)2.80771329
127sterol homeostasis (GO:0055092)2.80314743
128protein-lipid complex assembly (GO:0065005)2.80223044
129phospholipid homeostasis (GO:0055091)2.79132269
130* response to interferon-alpha (GO:0035455)2.78879631
131cellular biogenic amine catabolic process (GO:0042402)2.78078718
132amine catabolic process (GO:0009310)2.78078718
133indolalkylamine metabolic process (GO:0006586)2.77643129
134macrophage activation involved in immune response (GO:0002281)2.77042613
135modulation by symbiont of host defense response (GO:0052031)2.76652957
136modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.76652957
137modulation by symbiont of host immune response (GO:0052553)2.76652957
138detection of external biotic stimulus (GO:0098581)2.74132517
139regulation of type I interferon-mediated signaling pathway (GO:0060338)2.73644935
140positive regulation of defense response to virus by host (GO:0002230)2.73041694
141positive regulation of lymphocyte migration (GO:2000403)2.72876872
142negative regulation of innate immune response (GO:0045824)2.72357175
143modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.71369645
144positive regulation by organism of defense response of other organism involved in symbiotic interact2.71369645
145positive regulation by symbiont of host defense response (GO:0052509)2.71369645
146regulation of T-helper 1 cell differentiation (GO:0045625)2.69763802
147positive thymic T cell selection (GO:0045059)2.69321662
148response to protozoan (GO:0001562)2.64954729
149regulation of lymphocyte migration (GO:2000401)2.63933211
150defense response to protozoan (GO:0042832)2.63492471
151negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.61861204
152cytidine metabolic process (GO:0046087)2.58723825
153cytidine catabolic process (GO:0006216)2.58723825
154cytidine deamination (GO:0009972)2.58723825
155antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.58436631
156regulation of B cell differentiation (GO:0045577)2.57957451
157regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.57456605
158positive regulation of T cell mediated cytotoxicity (GO:0001916)2.56714789
159regulation of gamma-delta T cell differentiation (GO:0045586)2.54971559
160antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.52720675
161regulation of T cell mediated cytotoxicity (GO:0001914)2.50804991
162myeloid cell activation involved in immune response (GO:0002275)2.49064905
163cellular response to exogenous dsRNA (GO:0071360)2.48861131
164chaperone mediated protein folding requiring cofactor (GO:0051085)2.47804520
165negative regulation of type I interferon production (GO:0032480)2.47015353
166negative regulation of nitric oxide biosynthetic process (GO:0045019)2.43917305
167cellular response to virus (GO:0098586)2.43691505
168regulation of interleukin-2 biosynthetic process (GO:0045076)2.43139224
169regulation of alpha-beta T cell proliferation (GO:0046640)2.42836360
170regulation of superoxide anion generation (GO:0032928)2.42580122
171tumor necrosis factor-mediated signaling pathway (GO:0033209)2.42570329
172amino sugar catabolic process (GO:0046348)2.42136845
173regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.39964213
174positive regulation of T cell migration (GO:2000406)2.39707482
175* defense response to virus (GO:0051607)2.39617994
176regulation of T cell migration (GO:2000404)2.39592851
177lymphocyte migration (GO:0072676)2.39034842
178positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.38993246
179detection of biotic stimulus (GO:0009595)2.38392564
180positive regulation of type 2 immune response (GO:0002830)2.38038810
181germinal center formation (GO:0002467)2.37899548
182response to muramyl dipeptide (GO:0032495)2.37384197
183positive regulation of monocyte chemotaxis (GO:0090026)2.36478162
184dendritic cell differentiation (GO:0097028)2.36370932
185respiratory burst (GO:0045730)2.35646595
186* regulation of viral genome replication (GO:0045069)2.35248697

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.89967347
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.81710782
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.80838890
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.37367766
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.06990449
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.64396837
7* LXR_22158963_ChIP-Seq_LIVER_Mouse3.60072424
8* IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.47695745
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.40497677
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.20740521
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.79302549
12* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.70155468
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.46782955
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.29305712
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.15392878
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.14014072
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12270341
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.09574183
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.09406465
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.08955365
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.00642350
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.88425028
23GATA1_22025678_ChIP-Seq_K562_Human1.85668743
24MYB_21317192_ChIP-Seq_ERMYB_Mouse1.85375509
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.85101706
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.82313943
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.81797413
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79038128
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.72890313
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.65381405
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.64178044
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62232744
33CLOCK_20551151_ChIP-Seq_293T_Human1.60764714
34* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.60037018
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.59343657
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59153068
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.57841771
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.54876496
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.54591672
40TP63_17297297_ChIP-ChIP_HaCaT_Human1.53481673
41FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.49821775
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.46274220
43* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46137631
44VDR_21846776_ChIP-Seq_THP-1_Human1.45935932
45MAF_26560356_Chip-Seq_TH1_Human1.43842711
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40153469
47SCL_19346495_ChIP-Seq_HPC-7_Human1.38346092
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.37479318
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35358098
50ELK3_25401928_ChIP-Seq_HUVEC_Human1.33623154
51HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.32654400
52SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29205420
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29097304
54ELF1_20517297_ChIP-Seq_JURKAT_Human1.28927048
55MYC_22102868_ChIP-Seq_BL_Human1.28375915
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28364798
57* BCOR_27268052_Chip-Seq_Bcells_Human1.24511967
58* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.23722223
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23664689
60CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22450245
61SPI1_23547873_ChIP-Seq_NB4_Human1.21652876
62TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20521327
63CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17210311
64PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17158722
65CIITA_25753668_ChIP-Seq_RAJI_Human1.16922630
66STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.14646924
67* RUNX1_22412390_ChIP-Seq_EML_Mouse1.14531499
68LXR_22292898_ChIP-Seq_THP-1_Human1.14466305
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12175536
70MYB_26560356_Chip-Seq_TH2_Human1.11674021
71VDR_24763502_ChIP-Seq_THP-1_Human1.11386838
72TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.10696832
73HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.10205515
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09696976
75* MYB_26560356_Chip-Seq_TH1_Human1.09252718
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07810769
77TFEB_21752829_ChIP-Seq_HELA_Human1.07461068
78GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06834901
79* UTX_26944678_Chip-Seq_JUKART_Human1.05109788
80CTCF_26484167_Chip-Seq_Bcells_Mouse1.04244504
81NCOR1_26117541_ChIP-Seq_K562_Human1.03913004
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03770423
83GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02888913
84* P68_20966046_ChIP-Seq_HELA_Human1.02576865
85* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02495833
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01785351
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01641252
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00427042
89HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00204079
90PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99716494
91ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98317571
92KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97863246
93MAF_26560356_Chip-Seq_TH2_Human0.96634470
94TET1_21451524_ChIP-Seq_MESCs_Mouse0.96532432
95* SRF_21415370_ChIP-Seq_HL-1_Mouse0.94935831
96GATA3_27048872_Chip-Seq_THYMUS_Human0.93387522
97PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93193530
98TCF7_22412390_ChIP-Seq_EML_Mouse0.92693545
99* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91966347
100PU_27001747_Chip-Seq_BMDM_Mouse0.91630182
101PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87715281
102RACK7_27058665_Chip-Seq_MCF-7_Human0.84702681
103GATA2_21666600_ChIP-Seq_HMVEC_Human0.83450083
104TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.83241787
105ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82296501
106CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81945713
107RXRA_24833708_ChIP-Seq_LIVER_Mouse0.80715438
108KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.80563750
109CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80275773
110MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.79695599
111TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.79238917
112LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.78834209
113RUNX_20019798_ChIP-Seq_JUKART_Human0.78589434
114* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78079854
115KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.77778059
116FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.77645814
117SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77482925
118EGR1_19032775_ChIP-ChIP_M12_Human0.76744828
119RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.76514593
120GATA1_19941827_ChIP-Seq_MEL_Mouse0.75523472
121PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74289744
122BCL6_27268052_Chip-Seq_Bcells_Human0.73725367
123SPI1_23127762_ChIP-Seq_K562_Human0.72385263
124SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.71868393
125KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.71350145
126ZNF263_19887448_ChIP-Seq_K562_Human0.71326905
127SPI1_20517297_ChIP-Seq_HL60_Human0.70473363

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.95729390
2MP0005360_urolithiasis4.61840190
3MP0005085_abnormal_gallbladder_physiolo3.64625644
4MP0005365_abnormal_bile_salt3.58632994
5MP0009840_abnormal_foam_cell3.35757357
6MP0008875_abnormal_xenobiotic_pharmacok2.96181459
7MP0003191_abnormal_cellular_cholesterol2.75804376
8MP0001835_abnormal_antigen_presentation2.61175100
9MP0003806_abnormal_nucleotide_metabolis2.56608859
10MP0003252_abnormal_bile_duct2.34630615
11MP0005083_abnormal_biliary_tract2.33820667
12MP0010329_abnormal_lipoprotein_level2.33297552
13MP0003436_decreased_susceptibility_to2.30910503
14MP0009785_altered_susceptibility_to2.27013340
15MP0003724_increased_susceptibility_to2.17671931
16MP0003763_abnormal_thymus_physiology2.04192864
17MP0000685_abnormal_immune_system1.98982584
18MP0006082_CNS_inflammation1.88872699
19MP0005058_abnormal_lysosome_morphology1.87137604
20MP0005025_abnormal_response_to1.84752817
21MP0002138_abnormal_hepatobiliary_system1.82986618
22MP0000609_abnormal_liver_physiology1.78810335
23MP0003705_abnormal_hypodermis_morpholog1.78714654
24MP0003195_calcinosis1.74783753
25MP0003303_peritoneal_inflammation1.73238825
26MP0002419_abnormal_innate_immunity1.70439481
27MP0005464_abnormal_platelet_physiology1.65658788
28MP0008469_abnormal_protein_level1.61074287
29MP0001790_abnormal_immune_system1.56651478
30MP0005387_immune_system_phenotype1.56651478
31MP0005319_abnormal_enzyme/_coenzyme1.55435043
32MP0005332_abnormal_amino_acid1.54026044
33MP0001666_abnormal_nutrient_absorption1.52813895
34MP0009764_decreased_sensitivity_to1.52322882
35MP0005000_abnormal_immune_tolerance1.48914447
36MP0003186_abnormal_redox_activity1.45859509
37MP0001800_abnormal_humoral_immune1.45272770
38MP0004947_skin_inflammation1.43743128
39MP0002148_abnormal_hypersensitivity_rea1.40845390
40MP0001853_heart_inflammation1.39664485
41MP0002254_reproductive_system_inflammat1.39494384
42MP0002166_altered_tumor_susceptibility1.37662572
43MP0002452_abnormal_antigen_presenting1.36575171
44MP0002723_abnormal_immune_serum1.36114000
45MP0003300_gastrointestinal_ulcer1.35438887
46MP0000604_amyloidosis1.34560255
47MP0002118_abnormal_lipid_homeostasis1.34302046
48MP0004019_abnormal_vitamin_homeostasis1.30226726
49MP0001533_abnormal_skeleton_physiology1.29969137
50MP0001845_abnormal_inflammatory_respons1.29863355
51MP0004510_myositis1.29839861
52MP0008438_abnormal_cutaneous_collagen1.29441342
53MP0005671_abnormal_response_to1.26973720
54MP0009763_increased_sensitivity_to1.26942902
55MP0000598_abnormal_liver_morphology1.22162734
56MP0001873_stomach_inflammation1.18505528
57MP0010368_abnormal_lymphatic_system1.15672469
58MP0005584_abnormal_enzyme/coenzyme_acti1.15668651
59MP0005165_increased_susceptibility_to1.14987472
60MP0010155_abnormal_intestine_physiology1.14498687
61MP0000343_altered_response_to1.14397093
62MP0003866_abnormal_defecation1.13948352
63MP0003656_abnormal_erythrocyte_physiolo1.13183037
64MP0001819_abnormal_immune_cell1.13149650
65MP0002420_abnormal_adaptive_immunity1.11459496
66MP0009643_abnormal_urine_homeostasis1.08786515
67MP0008260_abnormal_autophagy1.06181896
68MP0005023_abnormal_wound_healing1.05878944
69MP0001764_abnormal_homeostasis1.05446999
70MP0005397_hematopoietic_system_phenotyp1.04624055
71MP0001545_abnormal_hematopoietic_system1.04624055
72MP0005310_abnormal_salivary_gland1.04374281
73MP0002006_tumorigenesis1.03519493
74MP0000858_altered_metastatic_potential1.03435114
75MP0002877_abnormal_melanocyte_morpholog1.03248826
76MP0003075_altered_response_to1.01358435
77MP0000703_abnormal_thymus_morphology1.00483386
78MP0003172_abnormal_lysosome_physiology1.00257840
79MP0009333_abnormal_splenocyte_physiolog1.00045985
80MP0003448_altered_tumor_morphology0.99764495
81MP0002132_abnormal_respiratory_system0.98920774
82MP0002405_respiratory_system_inflammati0.96656982
83MP0000689_abnormal_spleen_morphology0.93801389
84MP0000716_abnormal_immune_system0.93598635
85MP0003183_abnormal_peptide_metabolism0.92352794
86MP0009278_abnormal_bone_marrow0.91660565
87MP0003011_delayed_dark_adaptation0.91047675
88MP0004808_abnormal_hematopoietic_stem0.88551324
89MP0004782_abnormal_surfactant_physiolog0.86844761
90MP0000249_abnormal_blood_vessel0.86649835
91MP0002398_abnormal_bone_marrow0.86034383
92MP0000490_abnormal_crypts_of0.83869533
93MP0002019_abnormal_tumor_incidence0.83850842
94MP0002429_abnormal_blood_cell0.82981906
95MP0005164_abnormal_response_to0.82835673
96MP0005451_abnormal_body_composition0.82199040
97MP0002722_abnormal_immune_system0.81814590
98MP0003566_abnormal_cell_adhesion0.81146882
99MP0006054_spinal_hemorrhage0.81060785
100MP0003868_abnormal_feces_composition0.78992330
101MP0002396_abnormal_hematopoietic_system0.78981296
102MP0003453_abnormal_keratinocyte_physiol0.78817997
103MP0005166_decreased_susceptibility_to0.76800511
104MP0005390_skeleton_phenotype0.76229325
105MP0009642_abnormal_blood_homeostasis0.74197546
106MP0001881_abnormal_mammary_gland0.74073403
107MP0002998_abnormal_bone_remodeling0.73345491
108MP0005167_abnormal_blood-brain_barrier0.73078868
109MP0009697_abnormal_copulation0.72822255
110MP0010307_abnormal_tumor_latency0.72277352
111MP0002136_abnormal_kidney_physiology0.71885652
112MP0006036_abnormal_mitochondrial_physio0.71545164
113MP0002933_joint_inflammation0.71256061
114MP0001851_eye_inflammation0.69616687
115MP0008873_increased_physiological_sensi0.69415145
116MP0010352_gastrointestinal_tract_polyps0.67664858
117MP0000465_gastrointestinal_hemorrhage0.65688086
118MP0003045_fibrosis0.65431406
119MP0003795_abnormal_bone_structure0.63897502
120MP0008874_decreased_physiological_sensi0.63678327
121MP0001663_abnormal_digestive_system0.63014036
122MP0003690_abnormal_glial_cell0.61762832
123MP0009765_abnormal_xenobiotic_induced0.61716728
124MP0008004_abnormal_stomach_pH0.54415377
125MP0003329_amyloid_beta_deposits0.53752739

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.46055739
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.90387848
3Abnormality of glycolipid metabolism (HP:0010969)4.68486487
4Abnormality of liposaccharide metabolism (HP:0010968)4.68486487
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.68486487
6Intrahepatic cholestasis (HP:0001406)4.67492739
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.67169930
8Complement deficiency (HP:0004431)4.62151930
9Xanthomatosis (HP:0000991)4.59903170
10Prolonged partial thromboplastin time (HP:0003645)4.28288947
11Joint hemorrhage (HP:0005261)4.14454225
12Hypobetalipoproteinemia (HP:0003563)4.06148497
13Systemic lupus erythematosus (HP:0002725)4.04966034
14Recurrent gram-negative bacterial infections (HP:0005420)3.90262898
15Hyperlipoproteinemia (HP:0010980)3.86763331
16Abnormality of complement system (HP:0005339)3.71973104
17Mediastinal lymphadenopathy (HP:0100721)3.66337438
18Abnormality of the common coagulation pathway (HP:0010990)3.53747645
19Myocardial infarction (HP:0001658)3.42831744
20Eczematoid dermatitis (HP:0000976)3.22704747
21Recurrent viral infections (HP:0004429)3.20417587
22Meningitis (HP:0001287)3.18235601
23Chronic obstructive pulmonary disease (HP:0006510)3.17963891
24Obstructive lung disease (HP:0006536)3.17963891
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.12032609
26Hypolipoproteinemia (HP:0010981)3.08988853
27Orchitis (HP:0100796)3.08289001
28Recurrent bacterial skin infections (HP:0005406)3.02267559
29Epidermoid cyst (HP:0200040)3.01442159
30Elevated erythrocyte sedimentation rate (HP:0003565)2.99444138
31Glomerulonephritis (HP:0000099)2.98000874
32Hypercholesterolemia (HP:0003124)2.97076589
33Hyperammonemia (HP:0001987)2.96544708
34Abnormality of pyrimidine metabolism (HP:0004353)2.96389192
35Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.94488710
36Recurrent fungal infections (HP:0002841)2.93769313
37Agammaglobulinemia (HP:0004432)2.93159578
38Chronic otitis media (HP:0000389)2.90231901
39Increased IgM level (HP:0003496)2.88875888
40Gingival bleeding (HP:0000225)2.83523097
41Abnormality of the intrinsic pathway (HP:0010989)2.82569184
42Fat malabsorption (HP:0002630)2.81558274
43Stomatitis (HP:0010280)2.80093973
44Esophageal varix (HP:0002040)2.80084938
45Abnormality of sulfur amino acid metabolism (HP:0004339)2.79684051
46Vasculitis (HP:0002633)2.79477993
47Hypoalphalipoproteinemia (HP:0003233)2.79000566
48Recurrent abscess formation (HP:0002722)2.78879168
49Retrobulbar optic neuritis (HP:0100654)2.78416380
50Optic neuritis (HP:0100653)2.78416380
51Autoimmune hemolytic anemia (HP:0001890)2.75061074
52Hepatosplenomegaly (HP:0001433)2.72400087
53Abnormality of the nasal mucosa (HP:0000433)2.71970304
54Pulmonary infiltrates (HP:0002113)2.66474443
55Petechiae (HP:0000967)2.66315596
56Vacuolated lymphocytes (HP:0001922)2.65740184
57Recurrent cutaneous fungal infections (HP:0011370)2.64559442
58Chronic mucocutaneous candidiasis (HP:0002728)2.64559442
59Encephalitis (HP:0002383)2.58623100
60Autoimmune thrombocytopenia (HP:0001973)2.56692280
61Abnormal delayed hypersensitivity skin test (HP:0002963)2.56208955
62Abnormality of iron homeostasis (HP:0011031)2.52783182
63Spastic diplegia (HP:0001264)2.52566022
64Hypergammaglobulinemia (HP:0010702)2.51900496
65Abnormality of methionine metabolism (HP:0010901)2.51657280
66Nasal polyposis (HP:0100582)2.49969210
67Gastrointestinal stroma tumor (HP:0100723)2.45882807
68Nephritis (HP:0000123)2.44718108
69Abnormality of macrophages (HP:0004311)2.44636407
70T lymphocytopenia (HP:0005403)2.44057357
71Colitis (HP:0002583)2.44003103
72Abnormality of T cells (HP:0002843)2.43917241
73Increased serum ferritin (HP:0003281)2.43892458
74Increased IgE level (HP:0003212)2.41865092
75Amyloidosis (HP:0011034)2.40951038
76Abnormality of aspartate family amino acid metabolism (HP:0010899)2.39941822
77Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.39124021
78Cellulitis (HP:0100658)2.38313135
79Abnormality of T cell number (HP:0011839)2.38264855
80Spontaneous hematomas (HP:0007420)2.37967685
81Recurrent bronchitis (HP:0002837)2.37800326
82Interstitial pulmonary disease (HP:0006530)2.36707263
83Hemorrhage of the eye (HP:0011885)2.36450705
84Menorrhagia (HP:0000132)2.36021483
85Abnormality of nucleobase metabolism (HP:0010932)2.35685012
86Hypertensive crisis (HP:0100735)2.35506178
87Ketosis (HP:0001946)2.35376199
88Steatorrhea (HP:0002570)2.35339154
89Myositis (HP:0100614)2.30559898
90Abnormality of fatty-acid metabolism (HP:0004359)2.30114770
91Thrombophlebitis (HP:0004418)2.29725354
92Hypoglycemic coma (HP:0001325)2.29422028
93Abnormality of transition element cation homeostasis (HP:0011030)2.29351127
94Epistaxis (HP:0000421)2.28897733
95Tetraparesis (HP:0002273)2.28805219
96Panhypogammaglobulinemia (HP:0003139)2.28800733
97Abnormality of T cell physiology (HP:0011840)2.28657854
98Increased cerebral lipofuscin (HP:0011813)2.28480178
99Peritonitis (HP:0002586)2.27751831
100Recurrent skin infections (HP:0001581)2.26509282
101IgM deficiency (HP:0002850)2.23988329
102Axonal loss (HP:0003447)2.23445019
103Spontaneous abortion (HP:0005268)2.23148916
104Hyperbilirubinemia (HP:0002904)2.22468922
105Hepatocellular carcinoma (HP:0001402)2.22459726
106Progressive neurologic deterioration (HP:0002344)2.21740968
107Polycythemia (HP:0001901)2.21360481
108Granulocytopenia (HP:0001913)2.20169163
109Purpura (HP:0000979)2.20093806
110Ragged-red muscle fibers (HP:0003200)2.17187637
111Hyperglycinemia (HP:0002154)2.16157851
112Abnormality of the vasculature of the conjunctiva (HP:0008054)2.15763839
113Vertebral compression fractures (HP:0002953)2.15477924
114Mitral stenosis (HP:0001718)2.15407945
115Abnormality of polysaccharide metabolism (HP:0011012)2.12655998
116Pulmonary embolism (HP:0002204)2.11250373
117Abnormality of the prostate (HP:0008775)2.10093181
118Skin nodule (HP:0200036)2.09257804
119Skin rash (HP:0000988)2.08805250
120Mucopolysacchariduria (HP:0008155)2.08151843
121Urinary glycosaminoglycan excretion (HP:0003541)2.08151843
122Polygenic inheritance (HP:0010982)2.07936855
123Gastrointestinal inflammation (HP:0004386)2.07540707
124Abnormality of purine metabolism (HP:0004352)2.05332921
125Inflammation of the large intestine (HP:0002037)2.05099331
126Abnormal platelet volume (HP:0011876)2.03651626
127Hyperglycinuria (HP:0003108)2.03576779
128IgG deficiency (HP:0004315)2.03519168
129Abnormal platelet function (HP:0011869)2.02802860
130Impaired platelet aggregation (HP:0003540)2.02802860
131Lymphopenia (HP:0001888)2.02624844
132Conjunctival telangiectasia (HP:0000524)2.01778958
133Nausea (HP:0002018)2.01610094
134Pustule (HP:0200039)2.01319333
135Gingivitis (HP:0000230)2.01159052
136Increased neuronal autofluorescent lipopigment (HP:0002074)2.00671058
137Hemoptysis (HP:0002105)2.00528092
138Prolonged neonatal jaundice (HP:0006579)2.00338146
139Increased mean platelet volume (HP:0011877)1.99208352
140Dysostosis multiplex (HP:0000943)1.99136916
141Abnormal gallbladder physiology (HP:0012438)1.97157095
142Cholecystitis (HP:0001082)1.97157095
143Thrombocytosis (HP:0001894)1.96825309
144Loss of speech (HP:0002371)1.96775728
145IgA deficiency (HP:0002720)1.96577190
146Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.96526486
147Abnormality of cells of the lymphoid lineage (HP:0012140)1.96417641
148Vascular calcification (HP:0004934)1.95567534
149Abnormality of glycine metabolism (HP:0010895)1.94763314
150Abnormality of serine family amino acid metabolism (HP:0010894)1.94763314
151Urticaria (HP:0001025)1.94479885
152Keratoconjunctivitis sicca (HP:0001097)1.93681655
153Conjugated hyperbilirubinemia (HP:0002908)1.93118296
154Gangrene (HP:0100758)1.92566649
155Chest pain (HP:0100749)1.92091550
156Chronic diarrhea (HP:0002028)1.91829303
157Joint swelling (HP:0001386)1.91036852
158Acute hepatic failure (HP:0006554)1.90899298
159Abnormality of proline metabolism (HP:0010907)1.90077054
160Hydroxyprolinuria (HP:0003080)1.90077054
161Arterial thrombosis (HP:0004420)1.90029505
162Reduced antithrombin III activity (HP:0001976)1.90008127
163Abnormality of the pleura (HP:0002103)1.89709012
164Abnormality of mucopolysaccharide metabolism (HP:0011020)1.89121161
165Abnormality of glycosaminoglycan metabolism (HP:0004371)1.89121161
166Gastrointestinal infarctions (HP:0005244)1.88220370
167Recurrent sinusitis (HP:0011108)1.84545894
168Arthralgia (HP:0002829)1.83231261

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.16602287
2TYK23.57791702
3FGFR43.53079069
4TBK13.40088286
5KIT2.69946614
6IKBKE2.60247656
7BCKDK2.53789645
8PKN22.48355338
9TRIB32.48128947
10MAP4K12.47049577
11VRK22.32562789
12RIPK42.30682842
13MAP3K142.27399641
14NME22.25141268
15KDR2.22420117
16JAK32.17479389
17BLK2.06609971
18TGFBR21.98805287
19JAK11.88258126
20TESK11.85084375
21TAOK21.80967023
22FLT31.76117813
23SIK11.75574259
24PRPF4B1.74833335
25TAOK31.68271405
26IRAK31.63559266
27EPHB11.56938420
28MAP2K31.53404211
29ZAP701.51284335
30IKBKB1.51204085
31RPS6KA41.49398331
32ARAF1.48073680
33PIM21.44893095
34LRRK21.44044144
35NEK91.41571853
36CSK1.39307584
37TIE11.38265775
38SMG11.33699236
39PTK61.33171544
40CSF1R1.27342859
41IRAK41.21784258
42ABL21.17246846
43JAK21.16295079
44BTK1.14017521
45FGFR31.13788216
46STK101.11779186
47EEF2K1.04989048
48DAPK11.03429997
49MAPK111.03250109
50MAP3K31.02120273
51EPHA31.01502303
52MAP3K101.00979083
53TGFBR11.00063843
54BMPR20.95674615
55CHUK0.90939159
56GRK70.90936257
57BMX0.89883505
58CDK60.89392726
59GRK60.87083357
60PIM10.85284015
61HCK0.85214882
62SYK0.83740755
63TNK20.83224414
64MAP3K130.81762872
65TXK0.81525354
66TEC0.81424877
67MATK0.79960037
68MAP3K110.78480503
69RIPK10.77994546
70MST1R0.77258438
71PAK40.76493481
72LCK0.75057105
73PBK0.74294758
74LYN0.70209405
75TTN0.69223066
76PDK20.66821327
77PIK3CG0.65650247
78CDK40.63087101
79MAPK40.60513560
80ERBB40.60491059
81HIPK20.59702005
82MAP3K80.59661024
83EGFR0.58262909
84FES0.57980175
85PRKCQ0.54799426
86MST40.54714412
87ITK0.53842961
88SCYL20.53466014
89TLK10.52227535
90ABL10.51647172
91EPHA20.50932969
92PRKG20.48676916
93DYRK1B0.46373854
94LIMK10.46161535
95SIK30.44033057
96MAP2K60.43444266
97TAOK10.43420859
98MOS0.43192436
99DAPK30.43071577
100STK160.42980003
101VRK10.42951328
102MAPKAPK30.42580331
103TESK20.41115063
104RPS6KB20.40093360
105PDGFRA0.39134437
106MARK30.39095281
107CAMK1D0.36500663
108PAK10.35235142
109PTK20.34691152
110NLK0.34307737
111CDC42BPA0.33809826
112PRKCD0.32394731
113PDK10.32139576
114GSK3A0.31923733
115AURKA0.31529846
116MAP3K50.30815706
117PAK20.30726474
118STK40.30527692
119RPS6KA60.29600898
120MAPK70.28888597
121MAPKAPK20.28853671
122CCNB10.28762718
123PDPK10.28398153
124MAP3K10.27947070
125FGR0.26500128
126MAPK120.26223092
127MAP2K20.24873753
128MAPK30.24110797
129IGF1R0.23883562
130RPS6KA50.23211792
131IRAK10.22978686
132ACVR1B0.22839920

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.00804249
2Autoimmune thyroid disease_Homo sapiens_hsa053203.43985282
3Asthma_Homo sapiens_hsa053103.11660020
4Staphylococcus aureus infection_Homo sapiens_hsa051503.07209658
5Complement and coagulation cascades_Homo sapiens_hsa046103.01538589
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.97591397
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.96222214
8Arginine biosynthesis_Homo sapiens_hsa002202.65349821
9Type I diabetes mellitus_Homo sapiens_hsa049402.59934475
10Nitrogen metabolism_Homo sapiens_hsa009102.51304040
11Caffeine metabolism_Homo sapiens_hsa002322.46018220
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.25036500
13Tryptophan metabolism_Homo sapiens_hsa003802.19498389
14Rheumatoid arthritis_Homo sapiens_hsa053232.09040830
15Fatty acid degradation_Homo sapiens_hsa000712.03513352
16Proteasome_Homo sapiens_hsa030502.03449353
17Viral myocarditis_Homo sapiens_hsa054161.95347429
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.83441120
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.83066654
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.81927116
21Peroxisome_Homo sapiens_hsa041461.78382099
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.73791941
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.66745750
24PPAR signaling pathway_Homo sapiens_hsa033201.64169707
25Chemical carcinogenesis_Homo sapiens_hsa052041.57709335
26Histidine metabolism_Homo sapiens_hsa003401.57168189
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.55757758
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.48779461
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.40757927
30Selenocompound metabolism_Homo sapiens_hsa004501.39968156
31beta-Alanine metabolism_Homo sapiens_hsa004101.32794669
32Folate biosynthesis_Homo sapiens_hsa007901.29023620
33Retinol metabolism_Homo sapiens_hsa008301.28837954
34Systemic lupus erythematosus_Homo sapiens_hsa053221.27089793
35Fatty acid metabolism_Homo sapiens_hsa012121.26613493
36Sulfur relay system_Homo sapiens_hsa041221.26529792
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.26150229
38Leishmaniasis_Homo sapiens_hsa051401.24757370
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24430763
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15616079
41Phenylalanine metabolism_Homo sapiens_hsa003601.15039838
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12839324
43Propanoate metabolism_Homo sapiens_hsa006401.08067649
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.07992624
45ABC transporters_Homo sapiens_hsa020101.06689868
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06591643
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06345362
48Starch and sucrose metabolism_Homo sapiens_hsa005001.04659481
49Glycosaminoglycan degradation_Homo sapiens_hsa005311.02178011
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01878784
51Bile secretion_Homo sapiens_hsa049761.01473520
52Phagosome_Homo sapiens_hsa041451.01172233
53Salmonella infection_Homo sapiens_hsa051321.00804850
54Antigen processing and presentation_Homo sapiens_hsa046121.00259656
55One carbon pool by folate_Homo sapiens_hsa006700.97715338
56Biosynthesis of amino acids_Homo sapiens_hsa012300.97408320
57Measles_Homo sapiens_hsa051620.97116286
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.96799538
59Pentose phosphate pathway_Homo sapiens_hsa000300.95007482
60Epstein-Barr virus infection_Homo sapiens_hsa051690.94237344
61Pertussis_Homo sapiens_hsa051330.94211384
62Tyrosine metabolism_Homo sapiens_hsa003500.93197152
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.92986407
64Malaria_Homo sapiens_hsa051440.92765366
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92039014
66Butanoate metabolism_Homo sapiens_hsa006500.91612567
67Fat digestion and absorption_Homo sapiens_hsa049750.91345811
68Carbon metabolism_Homo sapiens_hsa012000.90091730
69Legionellosis_Homo sapiens_hsa051340.87087555
70Fructose and mannose metabolism_Homo sapiens_hsa000510.84671591
71Ribosome_Homo sapiens_hsa030100.81323797
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81259419
73Osteoclast differentiation_Homo sapiens_hsa043800.79763610
74Lysosome_Homo sapiens_hsa041420.79444129
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76063934
76Influenza A_Homo sapiens_hsa051640.74501832
77Pyruvate metabolism_Homo sapiens_hsa006200.71804581
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71380112
79Herpes simplex infection_Homo sapiens_hsa051680.70056616
80Steroid biosynthesis_Homo sapiens_hsa001000.69017436
81Acute myeloid leukemia_Homo sapiens_hsa052210.68403621
82Other glycan degradation_Homo sapiens_hsa005110.68220052
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68132561
84Arginine and proline metabolism_Homo sapiens_hsa003300.66786528
85Vitamin digestion and absorption_Homo sapiens_hsa049770.65705129
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65641997
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.65580961
88T cell receptor signaling pathway_Homo sapiens_hsa046600.63362032
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.60893020
90Primary immunodeficiency_Homo sapiens_hsa053400.60369660
91Fatty acid elongation_Homo sapiens_hsa000620.60155696
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59452097
93DNA replication_Homo sapiens_hsa030300.59140840
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59040623
95Galactose metabolism_Homo sapiens_hsa000520.58926207
96Hepatitis C_Homo sapiens_hsa051600.58803337
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56633878
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56060543
99Toxoplasmosis_Homo sapiens_hsa051450.56038576
100Prion diseases_Homo sapiens_hsa050200.55322819
101Chemokine signaling pathway_Homo sapiens_hsa040620.54616638
102Tuberculosis_Homo sapiens_hsa051520.54107813
103Base excision repair_Homo sapiens_hsa034100.53716371
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52771314
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52407738
106TNF signaling pathway_Homo sapiens_hsa046680.52292186
107Apoptosis_Homo sapiens_hsa042100.51815988
108HTLV-I infection_Homo sapiens_hsa051660.50808645
109Glutathione metabolism_Homo sapiens_hsa004800.50471199
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.50206127
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.49847199
112Lysine degradation_Homo sapiens_hsa003100.48859929
113N-Glycan biosynthesis_Homo sapiens_hsa005100.48457335
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45413449
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45015221
116Viral carcinogenesis_Homo sapiens_hsa052030.44268921
117B cell receptor signaling pathway_Homo sapiens_hsa046620.43922034
118Pyrimidine metabolism_Homo sapiens_hsa002400.43837775
119Graft-versus-host disease_Homo sapiens_hsa053320.41773772
120NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40451453
121Sulfur metabolism_Homo sapiens_hsa009200.39906365
122Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39686169
123Glycerolipid metabolism_Homo sapiens_hsa005610.39124609
124Oxidative phosphorylation_Homo sapiens_hsa001900.36982885
125African trypanosomiasis_Homo sapiens_hsa051430.36471417
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35751568
127Allograft rejection_Homo sapiens_hsa053300.35598755
128Hematopoietic cell lineage_Homo sapiens_hsa046400.35557554
129Shigellosis_Homo sapiens_hsa051310.33885774
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33693140
131Insulin resistance_Homo sapiens_hsa049310.32378685
132Arachidonic acid metabolism_Homo sapiens_hsa005900.32110871
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30873788
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30808376
135Hepatitis B_Homo sapiens_hsa051610.30077908
136Bladder cancer_Homo sapiens_hsa052190.28813653
137Leukocyte transendothelial migration_Homo sapiens_hsa046700.27333609
138Parkinsons disease_Homo sapiens_hsa050120.24713991

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