BSX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071996.85740061
2protein-cofactor linkage (GO:0018065)6.60372094
3pyrimidine nucleobase catabolic process (GO:0006208)5.15543859
4axonal fasciculation (GO:0007413)5.07242418
5response to misfolded protein (GO:0051788)5.01638202
6positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021104.89655394
7mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)4.89655394
8negative regulation of catenin import into nucleus (GO:0035414)4.87999938
9negative regulation of microtubule depolymerization (GO:0007026)4.80280571
10activation of adenylate cyclase activity (GO:0007190)4.72560446
11erythrocyte maturation (GO:0043249)4.61829765
12cerebellar Purkinje cell layer development (GO:0021680)4.60848598
13macroautophagy (GO:0016236)4.58170814
14dendritic spine morphogenesis (GO:0060997)4.55305455
15cerebellar Purkinje cell differentiation (GO:0021702)4.52335340
16neuron recognition (GO:0008038)4.42200209
17positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.38152706
18intra-S DNA damage checkpoint (GO:0031573)4.35904691
19regulation of microtubule depolymerization (GO:0031114)4.32234598
20establishment of planar polarity (GO:0001736)4.31961809
21establishment of tissue polarity (GO:0007164)4.31961809
22regulation of transforming growth factor beta2 production (GO:0032909)4.26938185
23negative regulation of organelle assembly (GO:1902116)4.26036313
24positive regulation of adenylate cyclase activity (GO:0045762)4.21427589
25regulation of synaptic vesicle transport (GO:1902803)4.19862112
26negative regulation of microtubule polymerization or depolymerization (GO:0031111)4.11734063
27spinal cord association neuron differentiation (GO:0021527)4.09790955
28nucleobase catabolic process (GO:0046113)4.02801011
29positive regulation of mitochondrial membrane permeability (GO:0035794)3.97734078
30negative regulation of circadian rhythm (GO:0042754)3.90015379
31growth hormone secretion (GO:0030252)3.87944162
32pyrimidine-containing compound salvage (GO:0008655)3.79625894
33pyrimidine nucleoside salvage (GO:0043097)3.79625894
34response to pheromone (GO:0019236)3.77789297
35central nervous system projection neuron axonogenesis (GO:0021952)3.67997194
36cellular response to epinephrine stimulus (GO:0071872)3.65830204
37negative regulation of axon extension involved in axon guidance (GO:0048843)3.62184987
38regulation of cell communication by electrical coupling (GO:0010649)3.59247112
39nucleoside transmembrane transport (GO:1901642)3.56624713
40forebrain neuron differentiation (GO:0021879)3.54715878
41respiratory system process (GO:0003016)3.51222809
42cytidine metabolic process (GO:0046087)3.50420807
43cytidine catabolic process (GO:0006216)3.50420807
44cytidine deamination (GO:0009972)3.50420807
45regulation of cardiac muscle cell contraction (GO:0086004)3.49556925
46proline transport (GO:0015824)3.48701926
47glutamate secretion (GO:0014047)3.47027254
48regulation of hydrogen peroxide metabolic process (GO:0010310)3.45749193
49regulation of telomere maintenance via telomerase (GO:0032210)3.45144832
50dendrite morphogenesis (GO:0048813)3.38866520
51locomotory exploration behavior (GO:0035641)3.38720286
52establishment of nucleus localization (GO:0040023)3.37857016
53positive regulation of cyclase activity (GO:0031281)3.37294291
54layer formation in cerebral cortex (GO:0021819)3.35636440
55facial nerve structural organization (GO:0021612)3.34529305
56neurofilament cytoskeleton organization (GO:0060052)3.33715803
57regulation of relaxation of muscle (GO:1901077)3.30250807
58vocalization behavior (GO:0071625)3.26872866
59lysosome localization (GO:0032418)3.24091360
60homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)3.21497813
61response to auditory stimulus (GO:0010996)3.19030241
62negative regulation of axon guidance (GO:1902668)3.15933737
63nerve growth factor signaling pathway (GO:0038180)3.15836290
64adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)3.15196015
65misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.14138495
66urogenital system development (GO:0001655)3.10866447
67receptor internalization (GO:0031623)3.09175808
68clathrin coat assembly (GO:0048268)3.07683127
69cranial nerve structural organization (GO:0021604)3.06925857
70pyrimidine ribonucleoside catabolic process (GO:0046133)3.06101657
71synaptic vesicle endocytosis (GO:0048488)3.02511148
72positive regulation of lyase activity (GO:0051349)3.02510794
73positive regulation of cellular response to oxidative stress (GO:1900409)2.99218431
74positive regulation of response to oxidative stress (GO:1902884)2.99218431
75central nervous system neuron development (GO:0021954)2.98923574
76positive regulation of transforming growth factor beta production (GO:0071636)2.97535375
77ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.97127503
78positive regulation of synapse assembly (GO:0051965)2.95237148
79regulation of adenylate cyclase activity (GO:0045761)2.91714240
80positive regulation of receptor biosynthetic process (GO:0010870)2.90912581
81positive regulation of heart rate (GO:0010460)2.89668990
82ionotropic glutamate receptor signaling pathway (GO:0035235)2.89661443
83regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.88469331
84phospholipase C-activating G-protein coupled receptor signaling pathway (GO:0007200)2.87161581
85positive regulation of synaptic transmission, GABAergic (GO:0032230)2.85944892
86granulocyte differentiation (GO:0030851)2.85422919
87negative regulation of dendrite development (GO:2000171)2.83982254
88axon extension (GO:0048675)2.82771020
89protein localization to synapse (GO:0035418)2.82257066
90dendritic spine organization (GO:0097061)2.79594160
91regulation of hydrogen peroxide-induced cell death (GO:1903205)2.78758088
92response to epinephrine (GO:0071871)2.78456972
93serotonin metabolic process (GO:0042428)2.78448164
94activation of phospholipase C activity (GO:0007202)2.75861012
95central nervous system neuron axonogenesis (GO:0021955)2.75398628
96regulation of axon extension involved in axon guidance (GO:0048841)2.73199740
97regulation of microtubule-based movement (GO:0060632)2.72256419
98alanine transport (GO:0032328)2.71763767
99synaptic vesicle exocytosis (GO:0016079)2.71101349
100neuromuscular process controlling posture (GO:0050884)2.71069832

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.49744659
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human4.81306159
3CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.73132326
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.90134820
5* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.82759248
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.73078115
7* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.64780455
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.58461303
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.58461303
10* EZH2_27294783_Chip-Seq_ESCs_Mouse2.56312034
11* EZH2_27304074_Chip-Seq_ESCs_Mouse2.52980767
12* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46444791
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.43827535
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.43473786
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39354024
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29617486
17* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29411049
18* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.26057721
19* CBX2_27304074_Chip-Seq_ESCs_Mouse2.11847580
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.08646408
21* EED_16625203_ChIP-ChIP_MESCs_Mouse2.05637837
22* REST_21632747_ChIP-Seq_MESCs_Mouse2.03219523
23ZNF274_21170338_ChIP-Seq_K562_Hela1.97787971
24TAF15_26573619_Chip-Seq_HEK293_Human1.95795431
25* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95726416
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.94534655
27* REST_18959480_ChIP-ChIP_MESCs_Mouse1.87850770
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.87125832
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85590978
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84048441
31GBX2_23144817_ChIP-Seq_PC3_Human1.83151172
32* RNF2_27304074_Chip-Seq_ESCs_Mouse1.81671389
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78195564
34DROSHA_22980978_ChIP-Seq_HELA_Human1.76748043
35CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.76567235
36* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.76136049
37* RING1B_27294783_Chip-Seq_ESCs_Mouse1.67171344
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64246682
39* RNF2_27304074_Chip-Seq_NSC_Mouse1.61390361
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59502769
41* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59469203
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58748036
43TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53611370
44POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.53611370
45RARB_27405468_Chip-Seq_BRAIN_Mouse1.44729053
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.44687924
47ESR1_21235772_ChIP-Seq_MCF-7_Human1.44622546
48IGF1R_20145208_ChIP-Seq_DFB_Human1.42538342
49P300_19829295_ChIP-Seq_ESCs_Human1.31376155
50* RING1B_27294783_Chip-Seq_NPCs_Mouse1.30848209
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30453816
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27056677
53AR_21572438_ChIP-Seq_LNCaP_Human1.26991107
54TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.26483261
55ZNF263_19887448_ChIP-Seq_K562_Human1.24779482
56ESR2_21235772_ChIP-Seq_MCF-7_Human1.22623270
57DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22536564
58RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.22245198
59ELK4_26923725_Chip-Seq_MESODERM_Mouse1.19299070
60KDM2B_26808549_Chip-Seq_K562_Human1.19184663
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.15372124
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12661483
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.11466409
64CTCF_27219007_Chip-Seq_Bcells_Human1.10530935
65AR_19668381_ChIP-Seq_PC3_Human1.10348434
66TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.10099211
67ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08419972
68MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07591597
69ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06212481
70STAT3_23295773_ChIP-Seq_U87_Human1.06095891
71KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05421519
72SOX2_21211035_ChIP-Seq_LN229_Gbm1.05414135
73OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05038068
74IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04241157
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03993432
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03955135
77TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03692269
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02091711
79KDM2B_26808549_Chip-Seq_REH_Human1.01422648
80PKCTHETA_26484144_Chip-Seq_BREAST_Human0.98954328
81P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98170291
82SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97236809
83RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97172234
84ERG_21242973_ChIP-ChIP_JURKAT_Human0.97015322
85SMAD3_21741376_ChIP-Seq_ESCs_Human0.96725738
86SMAD3_21741376_ChIP-Seq_HESCs_Human0.95629978
87* TP53_20018659_ChIP-ChIP_R1E_Mouse0.94129376
88ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93677273
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92554983
90SMAD4_21741376_ChIP-Seq_HESCs_Human0.92544407
91IRF1_19129219_ChIP-ChIP_H3396_Human0.91578068
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90115100
93EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88747168
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87187385
95AR_25329375_ChIP-Seq_VCAP_Human0.86846246
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.83732151
97TCF4_23295773_ChIP-Seq_U87_Human0.82456224
98TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.81725119
99EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.80160306
100YAP1_20516196_ChIP-Seq_MESCs_Mouse0.78389857

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting7.92422222
2MP0001529_abnormal_vocalization5.17736626
3MP0005645_abnormal_hypothalamus_physiol4.52761772
4MP0008995_early_reproductive_senescence4.02895210
5MP0003121_genomic_imprinting3.94846296
6MP0004859_abnormal_synaptic_plasticity3.29799805
7MP0006276_abnormal_autonomic_nervous3.19603644
8MP0008961_abnormal_basal_metabolism3.14422021
9MP0000778_abnormal_nervous_system2.74722368
10MP0003880_abnormal_central_pattern2.57774289
11MP0004270_analgesia2.48330390
12MP0003635_abnormal_synaptic_transmissio2.30859185
13MP0001440_abnormal_grooming_behavior2.17383913
14MP0001502_abnormal_circadian_rhythm1.95650160
15MP0002736_abnormal_nociception_after1.93522309
16MP0002063_abnormal_learning/memory/cond1.82938029
17MP0009745_abnormal_behavioral_response1.82261137
18MP0001968_abnormal_touch/_nociception1.82140934
19MP0003329_amyloid_beta_deposits1.71117936
20MP0001486_abnormal_startle_reflex1.69680841
21MP0002064_seizures1.69343741
22MP0002557_abnormal_social/conspecific_i1.66336641
23MP0005083_abnormal_biliary_tract1.66157271
24MP0005257_abnormal_intraocular_pressure1.55106400
25MP0010030_abnormal_orbit_morphology1.51354808
26MP0001984_abnormal_olfaction1.48695276
27MP0005646_abnormal_pituitary_gland1.47408054
28MP0002572_abnormal_emotion/affect_behav1.46490179
29MP0002184_abnormal_innervation1.44582311
30MP0002733_abnormal_thermal_nociception1.44040376
31MP0002909_abnormal_adrenal_gland1.40660248
32MP0001765_abnormal_ion_homeostasis1.40302060
33MP0003879_abnormal_hair_cell1.40264038
34MP0002837_dystrophic_cardiac_calcinosis1.36188807
35MP0004381_abnormal_hair_follicle1.35572191
36MP0005423_abnormal_somatic_nervous1.35534790
37MP0002638_abnormal_pupillary_reflex1.32863750
38MP0005076_abnormal_cell_differentiation1.32654854
39MP0004185_abnormal_adipocyte_glucose1.30848655
40MP0008004_abnormal_stomach_pH1.30362776
41MP0000462_abnormal_digestive_system1.26173341
42MP0000566_synostosis1.22414442
43MP0002734_abnormal_mechanical_nocicepti1.22350563
44MP0000538_abnormal_urinary_bladder1.21918893
45MP0005386_behavior/neurological_phenoty1.21068377
46MP0004924_abnormal_behavior1.21068377
47MP0000955_abnormal_spinal_cord1.19479957
48MP0002882_abnormal_neuron_morphology1.16653042
49MP0008569_lethality_at_weaning1.15390224
50MP0002139_abnormal_hepatobiliary_system1.14469980
51MP0000751_myopathy1.13092940
52MP0002067_abnormal_sensory_capabilities1.10475151
53MP0001970_abnormal_pain_threshold1.06873991
54MP0002272_abnormal_nervous_system1.06587531
55MP0002998_abnormal_bone_remodeling1.04689803
56MP0003172_abnormal_lysosome_physiology1.02712403
57MP0002152_abnormal_brain_morphology1.01962791
58MP0003385_abnormal_body_wall1.00739033
59* MP0002066_abnormal_motor_capabilities/c0.98633169
60MP0003690_abnormal_glial_cell0.96652643
61MP0008872_abnormal_physiological_respon0.94263236
62MP0000631_abnormal_neuroendocrine_gland0.93245583
63MP0001501_abnormal_sleep_pattern0.91664845
64MP0000026_abnormal_inner_ear0.87991628
65MP0005058_abnormal_lysosome_morphology0.87640677
66MP0001485_abnormal_pinna_reflex0.85679298
67MP0005187_abnormal_penis_morphology0.84407179
68MP0002752_abnormal_somatic_nervous0.84149544
69MP0003861_abnormal_nervous_system0.83973973
70* MP0003948_abnormal_gas_homeostasis0.83510230
71MP0000604_amyloidosis0.82870027
72MP0003137_abnormal_impulse_conducting0.81327263
73MP0004811_abnormal_neuron_physiology0.81282452
74MP0002938_white_spotting0.80658889
75MP0002735_abnormal_chemical_nociception0.79715053
76MP0006292_abnormal_olfactory_placode0.78938920
77* MP0002069_abnormal_eating/drinking_beha0.78905495
78MP0005248_abnormal_Harderian_gland0.78660627
79* MP0003953_abnormal_hormone_level0.78554609
80MP0005448_abnormal_energy_balance0.77079334
81MP0009046_muscle_twitch0.75756825
82MP0002102_abnormal_ear_morphology0.73385950
83MP0001963_abnormal_hearing_physiology0.72642648
84MP0003091_abnormal_cell_migration0.72639483
85MP0005636_abnormal_mineral_homeostasis0.71959318
86MP0001299_abnormal_eye_distance/0.71755386
87MP0005360_urolithiasis0.69730159
88* MP0005535_abnormal_body_temperature0.68225344
89MP0003632_abnormal_nervous_system0.67684044
90MP0005365_abnormal_bile_salt0.67456488
91MP0005670_abnormal_white_adipose0.66375918
92MP0002089_abnormal_postnatal_growth/wei0.65620881
93MP0003303_peritoneal_inflammation0.62727541
94MP0002970_abnormal_white_adipose0.62688582
95MP0000371_diluted_coat_color0.62148639
96MP0003631_nervous_system_phenotype0.61489492
97MP0000920_abnormal_myelination0.61264183
98MP0002081_perinatal_lethality0.58988355
99MP0001943_abnormal_respiration0.58695316
100MP0003633_abnormal_nervous_system0.57095761

Predicted human phenotypes

RankGene SetZ-score
1Failure to thrive in infancy (HP:0001531)7.14685141
2Focal motor seizures (HP:0011153)6.16020847
3Polyphagia (HP:0002591)6.09167812
4Absence seizures (HP:0002121)4.96721325
5Sleep apnea (HP:0010535)4.95800493
6Visual hallucinations (HP:0002367)4.82710432
7Abnormal eating behavior (HP:0100738)4.34118965
8Deep palmar crease (HP:0006191)4.31678403
9Focal seizures (HP:0007359)4.09878463
10Dialeptic seizures (HP:0011146)4.00279729
11Abnormality of the labia minora (HP:0012880)3.93567988
12Oligomenorrhea (HP:0000876)3.93030629
13Myopathic facies (HP:0002058)3.91605502
14Stenosis of the external auditory canal (HP:0000402)3.79501297
15Esotropia (HP:0000565)3.75302042
16Fair hair (HP:0002286)3.73241937
17Papilledema (HP:0001085)3.71201536
18Abnormality of glycolipid metabolism (HP:0010969)3.63959269
19Abnormality of liposaccharide metabolism (HP:0010968)3.63959269
20Abnormality of glycosphingolipid metabolism (HP:0004343)3.63959269
2111 pairs of ribs (HP:0000878)3.40591957
22J-shaped sella turcica (HP:0002680)3.27406804
23Narrow nasal bridge (HP:0000446)3.18812122
24Abnormality of polysaccharide metabolism (HP:0011012)3.13741379
25Abnormality of glycosaminoglycan metabolism (HP:0004371)3.13741379
26Abnormality of mucopolysaccharide metabolism (HP:0011020)3.13741379
27Supranuclear gaze palsy (HP:0000605)3.13046086
28Facial cleft (HP:0002006)3.11473551
29Macroorchidism (HP:0000053)3.09799752
30Micronodular cirrhosis (HP:0001413)3.02499219
31Labial hypoplasia (HP:0000066)2.97555585
32Oligodontia (HP:0000677)2.85992522
33Mild short stature (HP:0003502)2.81668799
34Spinal canal stenosis (HP:0003416)2.69271643
35Hypoventilation (HP:0002791)2.66621620
36Oligodactyly (hands) (HP:0001180)2.60155857
37Metaphyseal cupping (HP:0003021)2.59702330
38Hypoplastic female external genitalia (HP:0012815)2.58820658
39Absent speech (HP:0001344)2.56605187
40Generalized hypopigmentation of hair (HP:0011358)2.54419592
41Leiomyosarcoma (HP:0100243)2.52958644
42Uterine leiomyosarcoma (HP:0002891)2.52958644
43Menstrual irregularities (HP:0000858)2.52807776
44Conjugated hyperbilirubinemia (HP:0002908)2.51118368
45Diastasis recti (HP:0001540)2.47444412
46Missing ribs (HP:0000921)2.47280158
47Blue irides (HP:0000635)2.44661139
48Open mouth (HP:0000194)2.44569394
49Abnormal hair whorl (HP:0010721)2.42309142
50Increased serum pyruvate (HP:0003542)2.42168204
51Abnormality of glycolysis (HP:0004366)2.42168204
52Growth hormone deficiency (HP:0000824)2.41468959
53Microvesicular hepatic steatosis (HP:0001414)2.36578216
54Decreased electroretinogram (ERG) amplitude (HP:0000654)2.31235902
55Anterior segment dysgenesis (HP:0007700)2.25769059
56Abnormality of the anterior horn cell (HP:0006802)2.25429214
57Degeneration of anterior horn cells (HP:0002398)2.25429214
58Ankyloglossia (HP:0010296)2.21752661
59Oligodactyly (HP:0012165)2.19997652
60Dysphonia (HP:0001618)2.18897818
61Aplasia/Hypoplasia of the clavicles (HP:0006710)2.17558125
62Split foot (HP:0001839)2.17020061
63Severe muscular hypotonia (HP:0006829)2.16960376
64Lissencephaly (HP:0001339)2.13750653
65Choroideremia (HP:0001139)2.12087318
66Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.09057623
67Tubulointerstitial nephritis (HP:0001970)2.04524049
68Short clavicles (HP:0000894)2.03916941
69Thin ribs (HP:0000883)2.03626452
70Acute hepatic failure (HP:0006554)2.03014620
71Neurofibrillary tangles (HP:0002185)2.01903324
72Myokymia (HP:0002411)2.00362970
73Aplasia of the musculature (HP:0100854)2.00015495
74Agitation (HP:0000713)1.96002440
75Epidermoid cyst (HP:0200040)1.95544918
76Asymmetric growth (HP:0100555)1.95372700
77Decreased muscle mass (HP:0003199)1.93801280
78Mixed hearing impairment (HP:0000410)1.93547431
79Psychosis (HP:0000709)1.93088380
80Depression (HP:0000716)1.92490410
81Shoulder girdle muscle weakness (HP:0003547)1.89970740
82Poor suck (HP:0002033)1.89882463
83Transitional cell carcinoma of the bladder (HP:0006740)1.88787970
84Drooling (HP:0002307)1.87721536
85Excessive salivation (HP:0003781)1.87721536
86Abnormality of the calcaneus (HP:0008364)1.87338522
87Anteriorly placed anus (HP:0001545)1.87257312
88Atonic seizures (HP:0010819)1.86479563
89Delayed CNS myelination (HP:0002188)1.86272181
90Aplasia/Hypoplasia of the brainstem (HP:0007362)1.84351803
91Hypoplasia of the brainstem (HP:0002365)1.84351803
92Hypogonadotrophic hypogonadism (HP:0000044)1.83706320
93Astrocytoma (HP:0009592)1.82143472
94Abnormality of the astrocytes (HP:0100707)1.82143472
95Abnormality of the labia (HP:0000058)1.81654852
96Generalized tonic-clonic seizures (HP:0002069)1.81231025
97Ragged-red muscle fibers (HP:0003200)1.76613363
98Generalized hypotonia (HP:0001290)1.75990257
99Abnormal pancreas size (HP:0012094)1.75150194
100Abnormality of the motor neurons (HP:0002450)1.74693932

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK34.41886782
2VRK14.09715515
3MAP3K93.59004663
4BCR3.51082994
5MARK13.01964518
6KSR12.99257393
7DDR22.90408394
8TYRO32.72548919
9ERN12.33871730
10CAMK1D2.29143479
11CAMK1G2.22499438
12IRAK42.22468158
13MAP3K122.20527161
14IRAK22.17981352
15PDGFRA2.14147511
16TAOK21.83189780
17NTRK21.72738666
18MINK11.66207118
19MAP2K41.65806401
20UHMK11.64166157
21NME11.60946932
22MAP2K71.56761618
23MATK1.53471104
24EPHB21.47693383
25RIPK41.47382997
26CSNK1G31.46225373
27CSNK1A1L1.43772267
28NTRK31.40528001
29CDK181.38974934
30PAK61.36679250
31EEF2K1.32051486
32FGFR21.30832429
33CSNK1G21.30497971
34PAK31.28978274
35MAP3K41.28695241
36STK381.28660606
37CCNB11.28109225
38IRAK11.26336179
39TNIK1.26101018
40RIPK11.23563530
41CSNK1G11.17991999
42CDK151.16472693
43FER1.04249714
44KSR21.01607761
45CDK11A1.00764400
46FGR1.00489465
47PRKD21.00114200
48CDK140.98698705
49PLK30.93495388
50MAPK130.91258544
51PRPF4B0.89209708
52NTRK10.87448509
53CDK50.84525537
54LATS20.82815974
55FES0.76898891
56TLK10.75514930
57PRKCH0.69932314
58MAPKAPK50.69847402
59CDK120.68328436
60PNCK0.67510636
61CDC42BPA0.66148972
62SIK20.65455179
63EPHB10.64961777
64CAMK10.60208494
65PRKCE0.60122575
66STK110.55227328
67MAPK90.55149896
68PRKACG0.49392278
69FGFR40.48210295
70CDK190.47620894
71MAPK100.46978679
72PKN20.46255686
73BLK0.46102860
74ERBB20.42962609
75OXSR10.42820480
76CSNK1E0.42532411
77ICK0.40825252
78FYN0.39555986
79PRKACA0.38888779
80EGFR0.37453949
81ROCK20.36588943
82DAPK20.36284971
83DYRK1A0.35142562
84PRKD10.34253839
85CASK0.33806028
86CLK10.33771306
87RET0.33562476
88MAP2K60.29880206
89PDGFRB0.28665046
90PKN10.28115534
91STK390.27929564
92ALK0.27745672
93RPS6KA30.23650673
94ABL20.23019810
95PRKCB0.22501748
96SRPK10.22261479
97PHKG10.21514539
98PHKG20.21514539
99CSNK1D0.20338443
100HCK0.20177685

Predicted pathways (KEGG)

RankGene SetZ-score
1Cocaine addiction_Homo sapiens_hsa050303.00484274
2Nitrogen metabolism_Homo sapiens_hsa009102.89656759
3Insulin secretion_Homo sapiens_hsa049112.65989676
4Axon guidance_Homo sapiens_hsa043602.62220675
5GABAergic synapse_Homo sapiens_hsa047272.59530308
6Nicotine addiction_Homo sapiens_hsa050332.47849544
7Aldosterone synthesis and secretion_Homo sapiens_hsa049252.43019325
8Morphine addiction_Homo sapiens_hsa050322.41649771
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.18401557
10Circadian entrainment_Homo sapiens_hsa047132.04369840
11Amphetamine addiction_Homo sapiens_hsa050312.01779026
12Synaptic vesicle cycle_Homo sapiens_hsa047211.98268228
13Glutamatergic synapse_Homo sapiens_hsa047241.93659525
14Dopaminergic synapse_Homo sapiens_hsa047281.91493810
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90744276
16Renin-angiotensin system_Homo sapiens_hsa046141.78320136
17Basal cell carcinoma_Homo sapiens_hsa052171.74507929
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.74257538
19Olfactory transduction_Homo sapiens_hsa047401.45498849
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.39248460
21Gap junction_Homo sapiens_hsa045401.39009045
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37490899
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36253412
24Salivary secretion_Homo sapiens_hsa049701.35330599
25Wnt signaling pathway_Homo sapiens_hsa043101.35107528
26Estrogen signaling pathway_Homo sapiens_hsa049151.34915843
27Arginine biosynthesis_Homo sapiens_hsa002201.29706717
28GnRH signaling pathway_Homo sapiens_hsa049121.25719784
29Alcoholism_Homo sapiens_hsa050341.20828662
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.18277808
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14645609
32Dorso-ventral axis formation_Homo sapiens_hsa043201.12119564
33Melanogenesis_Homo sapiens_hsa049161.10103637
34Serotonergic synapse_Homo sapiens_hsa047261.09980854
35Thyroid hormone synthesis_Homo sapiens_hsa049181.03408513
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98021683
37Long-term depression_Homo sapiens_hsa047300.96479420
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96415650
39Gastric acid secretion_Homo sapiens_hsa049710.96006609
40Colorectal cancer_Homo sapiens_hsa052100.93396457
41Phospholipase D signaling pathway_Homo sapiens_hsa040720.93352846
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92186257
43Butanoate metabolism_Homo sapiens_hsa006500.90109155
44Long-term potentiation_Homo sapiens_hsa047200.88986024
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87534516
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86970407
47Oxytocin signaling pathway_Homo sapiens_hsa049210.86612593
48Cardiac muscle contraction_Homo sapiens_hsa042600.86505784
49cAMP signaling pathway_Homo sapiens_hsa040240.84666148
50ErbB signaling pathway_Homo sapiens_hsa040120.83394053
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83089890
52Fatty acid biosynthesis_Homo sapiens_hsa000610.80483253
53Calcium signaling pathway_Homo sapiens_hsa040200.79862090
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.77609635
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.77102331
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.75748510
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74425811
58Renin secretion_Homo sapiens_hsa049240.74194681
59Taste transduction_Homo sapiens_hsa047420.73049225
60Shigellosis_Homo sapiens_hsa051310.72810154
61Bile secretion_Homo sapiens_hsa049760.72404062
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71784264
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.68548006
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68191857
65Osteoclast differentiation_Homo sapiens_hsa043800.68128437
66Endometrial cancer_Homo sapiens_hsa052130.67776005
67MAPK signaling pathway_Homo sapiens_hsa040100.65639187
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63713803
69Hippo signaling pathway_Homo sapiens_hsa043900.63276602
70Salmonella infection_Homo sapiens_hsa051320.62869398
71Glucagon signaling pathway_Homo sapiens_hsa049220.61761102
72Choline metabolism in cancer_Homo sapiens_hsa052310.60375933
73Oocyte meiosis_Homo sapiens_hsa041140.58965294
74Prion diseases_Homo sapiens_hsa050200.56810553
75Cholinergic synapse_Homo sapiens_hsa047250.56719267
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54924798
77Fatty acid metabolism_Homo sapiens_hsa012120.54798101
78Lysosome_Homo sapiens_hsa041420.54421142
79Sulfur relay system_Homo sapiens_hsa041220.53892349
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53783266
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49601413
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.48795315
83Dilated cardiomyopathy_Homo sapiens_hsa054140.48496922
84beta-Alanine metabolism_Homo sapiens_hsa004100.48252013
85MicroRNAs in cancer_Homo sapiens_hsa052060.46119138
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43862285
87VEGF signaling pathway_Homo sapiens_hsa043700.43638182
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.39750739
89Type I diabetes mellitus_Homo sapiens_hsa049400.37249793
90Rap1 signaling pathway_Homo sapiens_hsa040150.36746309
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35998715
92Ras signaling pathway_Homo sapiens_hsa040140.35966098
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35802758
94Tryptophan metabolism_Homo sapiens_hsa003800.31833292
95Glioma_Homo sapiens_hsa052140.31743900
96Viral myocarditis_Homo sapiens_hsa054160.30439223
97Inositol phosphate metabolism_Homo sapiens_hsa005620.29570433
98Sphingolipid metabolism_Homo sapiens_hsa006000.29495362
99Collecting duct acid secretion_Homo sapiens_hsa049660.28619049
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28458372

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